Recent Discoveries
洛杉矶-神经退行性疾病影响着全球 5700 多万人。从阿尔茨海默氏症到帕金森氏症，再到渐冻症等，这些疾病的发病率预计将达到 双 每20年。尽管科学家们知道衰老是神经退行性疾病的主要风险因素，但衰老影响的确切机制仍不清楚。.
洛杉矶-应对感染并不像杀死病原体那么简单。人体还需要仔细引导和监控其免疫反应，以防止附带损害。这种被称为疾病耐受性的调节对于在免疫系统正面应对感染时保护我们的组织至关重要。.
拉霍亚——年幼的心灵很容易塑造。每一次新的经历都会重塑孩子的大脑回路，在神经元之间添加和移除突触连接。这些连接模式会随着年龄增长而变得更加稳定，但生物学留出了一些灵活性，以确保成年人的大脑仍然能够根据需要进行调整和完善其回路。这种灵活性被称为 神经可塑性, ，我们学习、形成新记忆以及从伤病中恢复的能力都依赖于它。.
拉霍亚—索尔克学会教员 约瑟夫·埃克尔,博士, 罗纳德·埃文斯, 博士，, 鲁斯蒂·盖奇,博士, 克里斯蒂安·梅塔洛, 博士，, 萨奇达南达·潘达, 博士，, 鲁本-肖, 博士，以及 凯泰, ，博士，以及研究助理约瑟夫·内里，都被提名为今年的 科睿唯安高被引研究员名单. 2025年榜单共有来自60个国家的6,868名研究人员，他们在各自的研究领域表现出“显著而广泛的影响力”。”
拉霍亚——正如蜜蜂通过授粉和使花朵绽放来给予花园生命一样，一种名为线粒体的小型细胞机器也赋予我们的身体生命，它们嗡嗡作响地产生能量，为我们细胞的每一项功能提供动力。维持线粒体代谢需要许多分子和蛋白质的参与——其中一些仍有待发现。.
LA JOLLA—Salk Institute Professor 萨奇达南达·潘达 has been named a semifinalist in the XPRIZE Healthspan competition. Panda’s team is known for its expertise in circadian rhythms, the body’s internal timetable that determines the timing of our behaviors, such as sleep and wakefulness, and almost every bodily function.
LA JOLLA—About one in eight adults in the United States has tried or currently uses a GLP-1 medication, and a quarter of those users cite weight loss as their main goal. But weight loss doesn’t discriminate between fat and muscle. Patients using GLP-1 drugs can experience rapid and substantial muscle loss, accounting for as much as 40% of their total weight loss. So how can we lose weight without also losing critical muscle?
LA JOLLA—Excess cholesterol is known to form artery-clogging plaques that can lead to stroke, arterial disease, heart attack, and more, making it the focus of many heart health campaigns. Fortunately, this attention to cholesterol has prompted the development of cholesterol-lowering drugs called statins and lifestyle interventions like dietary and exercise regimens. But what if there’s more to the picture than just cholesterol?
LA JOLLA—The National Institutes of Health (NIH) has selected Salk Associate Professor 尼古拉·艾伦 to receive a 2024 NIH Director’s Pioneer Award. The award recognizes exceptionally creative scientists pursuing highly innovative research and groundbreaking approaches to major challenges in biomedical, behavioral, or social sciences.
LA JOLLA—Scientists at the Salk Institute are unveiling a new brain-mapping neurotechnology called Single Transcriptome Assisted Rabies Tracing (START). The cutting-edge tool combines two advanced technologies—monosynaptic rabies virus tracing and single-cell transcriptomics—to map the brain’s intricate neuronal connections with unparalleled precision.
LA JOLLA—More than one-third of adults in the United States have metabolic syndrome, a cluster of conditions that significantly raise a person’s risk of heart disease, stroke, and type 2 diabetes. These conditions include high blood pressure, elevated blood sugar, excess abdominal fat, and abnormal cholesterol levels.
LA JOLLA—The Salk Institute was awarded $3.6 million by the California Institute for Regenerative Medicine (CIRM), one of the world’s largest institutions dedicated to regenerative medicine. Salk Professor 鲁斯蒂·盖奇 will lead the new CIRM-funded Shared Resources Laboratory focused on stem cell-based models of aging and neurodegeneration.
LA JOLLA—Within each of our cells, long strands of DNA are folded into chromosomes and capped with protective structures called telomeres. But telomeres shorten as we age, eventually getting so whittled down that our chromosomes become exposed, and our cells die. However, the specifics of when and how this shortening occurs and whether certain chromosomes are more affected than others have been unclear—until now.
LA JOLLA—One in every 10 individuals above the age of 65 develops an age-related neurological disorder like Alzheimer’s or Parkinson’s, yet treatment options remain sparse for this population. Scientists have begun exploring whether cannabinoids—compounds derived from the cannabis plant, like well-known THC (tetrahydrocannabinol) and CBD (cannabidiol)—may offer a solution. A third, lesser-known cannabinoid called CBN (cannabinol) has recently piqued the interest of researchers, who have begun exploring the clinical potential of the milder, less psychoactive substance.
LA JOLLA—The brain is typically depicted as a complex web of neurons sending and receiving messages. But neurons only make up half of the human brain. The other half—roughly 85 billion cells—are non-neuronal cells called glia. The most common type of glial cells are astrocytes, which are important for supporting neuronal health and activity. Despite this, most existing laboratory models of the human brain fail to include astrocytes at sufficient levels or at all, which limits the models’ utility for studying brain health and disease.
LA JOLLA—Surveys show most men in the United States are interested in using male contraceptives, yet their options remain limited to unreliable condoms or invasive vasectomies. Recent attempts to develop drugs that block sperm production, maturation, or fertilization have had limited success, providing incomplete protection or severe side effects. New approaches to male contraception are needed, but because sperm development is so complex, researchers have struggled to identify parts of the process that can be safely and effectively tinkered with.
LA JOLLA—Cells in the human body contain power-generating mitochondria, each with their own mtDNA—a unique set of genetic instructions entirely separate from the cell’s nuclear DNA that mitochondria use to create life-giving energy. When mtDNA remains where it belongs (inside of mitochondria), it sustains both mitochondrial and cellular health—but when it goes where it doesn’t belong, it can initiate an immune response that promotes inflammation.
LA JOLLA—Salk Institute Professor 鲁斯蒂·盖奇 助理教授 Pallav Kosuri have been awarded $1.3 million by the W. M. Keck Foundation to fund a novel investigation into the way brain and heart cell functions decline over time due to ribosubstitution events—cellular repair of DNA damage with RNA building blocks rather than DNA building blocks. The award combines the biological discovery of ribosubstitution made by Senior Research Associate Jeff Jones in Gage’s lab with the technological advancements established by Postdoctoral Researcher Yuening Liu in Kosuri’s lab. The W. M. Keck Foundation was established with the goal of generating far-reaching benefits for humanity by supporting outstanding science, engineering, and medical research.
LA JOLLA—The Salk Institute and Autobahn Labs, an early-stage drug discovery incubator, will work together to identify and advance promising initial scientific discoveries through the preliminary steps of drug discovery and development. Autobahn Labs will invest up to $5 million per project for Salk discoveries that require access to drug development expertise and state-of-the art capabilities.
LA JOLLA—Brains are like puzzles, requiring many nested and codependent pieces to function well. The brain is divided into areas, each containing many millions of neurons connected across thousands of synapses. These synapses, which enable communication between neurons, depend on even smaller structures: message-sending boutons (swollen bulbs at the branch-like tips of neurons), message-receiving dendrites (complementary branch-like structures for receiving bouton messages), and power-generating mitochondria. To create a cohesive brain, all these pieces must be accounted for.
LA JOLLA—As we age, the end caps of our chromosomes, called telomeres, gradually shorten. Now, Salk scientists have discovered that when telomeres become very short, they communicate with mitochondria, the cell’s powerhouses. This communication triggers a complex set of signaling pathways and initiates an inflammatory response that destroys cells that could otherwise become cancerous.
LA JOLLA—Despite decades of research, Alzheimer’s disease remains a debilitating and eventually fatal dementia with no effective treatment options. More than 95 percent of Alzheimer’s disease cases have no known origin. Now, scientists from the Salk Institute have found that neurons from people with Alzheimer’s disease show deterioration and undergo a late-life stress process called senescence. These neurons have a loss of functional activity, impaired metabolism, and increased brain inflammation.
LA JOLLA—Aging involves complicated plot twists and a large cast of characters: inflammation, stress, metabolism changes, and many others. Now, a team of Salk Institute and UC San Diego scientists reveal another factor implicated in the aging process—a class of lipids called SGDGs (3-sulfogalactosyl diacylglycerols) that decline in the brain with age and may have anti-inflammatory effects.
LA JOLLA—The San Diego Nathan Shock Center of Excellence in the Basic Biology of Aging, a collaboration between the Salk Institute, UC San Diego, and Sanford Burnham Prebys, received new funding from the National Institutes of Health (NIH) to enroll participants from the Rancho Bernardo Study of Healthy Aging into their own clinical cohort to study differences in how individuals age. Initiated 50 years ago by the late UC San Diego Distinguished Professor Elizabeth Barrett-Connor, the Rancho Bernardo Study is one of the longest, continuously NIH-funded studies in existence.
拉霍亚—消防员是我们社会的英雄，全天候保护着我们。但这些 24 小时的轮班工作对身体非常不利，并且会增加患心脏代谢疾病（如心脏病和糖尿病）以及癌症的风险。圣地亚哥消防局与索尔克研究所和加州大学圣地亚哥分校健康中心的科学家合作进行的一项临床试验发现，限时进食可以改善消防员的健康和福祉指标。这种生活方式干预措施仅要求消防员在 10 小时的时间窗口内进食，并且不涉及跳餐。.
LA JOLLA—A stretch of DNA that hops around the human genome plays a role in premature aging disorders, scientists at the Salk Institute and King Abdullah University of Science and Technology (KAUST) in Saudi Arabia have discovered. In people with early aging, or progeria, RNA encoded by this mobile DNA builds up inside cells. What’s more, the scientists found that blocking this RNA reverses the disease in mice.
LA JOLLA— Mitochondria are known as cells’ powerhouses, but mounting evidence suggests they also play a role in inflammation. Scientists from the Salk Institute and UC San Diego published new findings in 免疫 on August 2, 2022, where they examined human blood cells and discovered a surprising link between mitochondria, inflammation and DNMT3A and TET2—two genes that normally help regulate blood cell growth but, when mutated, are associated with an increased risk of atherosclerosis.
LA JOLLA—Mammals can’t typically regenerate organs as efficiently as other vertebrates, such as fish and lizards. Now, Salk scientists have found a way to partially reset liver cells to more youthful states—allowing them to heal damaged tissue at a faster rate than previously observed. The results, published in Cell Reports on April 26, 2022, reveal that the use of reprogramming molecules can improve cell growth, leading to better liver tissue regeneration in mice.
拉霍亚—年龄只是一个数字，但它常常会带来不受欢迎的副作用，从骨骼脆弱、肌肉无力到心血管疾病和癌症风险增加。现在，索尔克研究所的科学家们与罗氏集团成员基因泰克公司合作，已经证明他们可以在中年和老年小鼠身上安全有效地逆转衰老过程，方法是将它们的细胞部分重置到更年轻的状态。这项研究发表在 自然衰老 2022年3月7日.
LA JOLLA—The Salk Institute announced today that Professor 胡安·卡洛斯·伊兹皮苏亚·贝尔蒙特, a world-renowned researcher who has pioneered innovations in developmental biology, regenerative medicine and aging research at the Salk Institute, will be closing his Salk laboratory to join Altos Labs, a newly created life sciences company centered on human health research. Izpisua Belmonte, who has been at Salk for nearly thirty years, will depart to lead the San Diego division of Altos Institutes of Science to study cellular rejuvenation programming with the goal of improving human health.
LA JOLLA—The San Diego Nathan Shock Center (SD-NSC) of Excellence in the Basic Biology of Aging, a consortium between the Salk Institute for Biological Studies, Sanford Burnham Prebys (SBP) and the University of California San Diego, has announced its second-year class of pilot grant awardees. Recipients from six different institutions will receive up to $15,000 to pursue research that advances our understanding of how humans age, with the ultimate goal of extending health span, the number of years of healthy, disease-free life.
LA JOLLA—Mitochondria are known as the powerhouses of the cell, generating the energy that’s needed to fuel the functions that our cells carry out. Now, scientists at the Salk Institute and the University of California San Diego (UCSD) have taken a closer look at how mitochondria are maintained in nondividing cells, such as neurons, with the ultimate goal of developing a better understanding of how to prevent or treat age-related diseases. The researchers found that many of the proteins in mitochondria last much longer than expected, and that this stability likely protects them from damage. The findings were published October 28, 2021, in Developmental Cell.
LA JOLLA—Sanford Burnham Prebys Professor Peter D. Adams, who directs the Aging, Cancer and Immuno-oncology Program, and Salk Institute Professor 杰拉尔德·沙德尔, who directs the San Diego Nathan Shock Center of Excellence in the Basic Biology of Aging, have been awarded a grant from the NIH’s National Institute on Aging for $13 million, funding a five-year project to explore the connection between aging and liver cancer.
LA JOLLA—One of the many effects of aging is loss of muscle mass, which contributes to disability in older people. To counter this loss, scientists at the Salk Institute are studying ways to accelerate the regeneration of muscle tissue, using a combination of molecular compounds that are commonly used in stem-cell research.
LA JOLLA—Despite the prevalence of Alzheimer’s, there are still no treatments, in part because it has been challenging to study how the disease develops. Now, scientists at the Salk Institute have uncovered new insights into what goes awry during Alzheimer’s by growing neurons that resemble—more accurately than ever before—brain cells in older patients. And like patients themselves, the afflicted neurons appear to lose their cellular identity.
LA JOLLA—The San Diego Nathan Shock Center (SD-NSC) of Excellence in the Basic Biology of Aging, a consortium between the Salk Institute for Biological Studies, Sanford Burnham Prebys (SBP) Medical Discovery Institute and the University of California San Diego, has announced the first class of pilot grant awardees at the center’s inaugural training workshop. Six recipients, each from a different institution, will receive up to $15,000 to pursue research that advances our understanding of how humans age, with the ultimate goal of extending the number of years of healthy, disease-free life (i.e., health span).
LA JOLLA—The ability to grow the cells of one species within an organism of a different species offers scientists a powerful tool for research and medicine. It’s an approach that could advance our understanding of early human development, disease onset and progression and aging; provide innovative platforms for drug evaluation; and address the critical need for transplantable organs. Yet developing such capabilities has been a formidable challenge.
LA JOLLA—One of the characteristic hallmarks of Alzheimer’s disease (AD) is the buildup of amyloid-beta plaques in the brain. Most therapies designed to treat AD target these plaques, but they’ve largely failed in clinical trials. New research by Salk scientists upends conventional views of the origin of one prevalent type of plaque, indicating a reason why treatments have been unsuccessful.
LA JOLLA—When cells are stressed, chemical alarms go off, setting in motion a flurry of activity that protects the cell’s most important players. During the rush, a protein called Parkin hurries to protect the mitochondria, the power stations that generate energy for the cell. Now Salk researchers have discovered a direct link between a master sensor of cell stress and Parkin itself. The same pathway is also tied to type 2 diabetes and cancer, which could open a new avenue for treating all three diseases.
LA JOLLA—A collaborative team of Salk scientists led by Professor 约翰·雷诺兹 will receive $1.2 million over four years as part of a Network Grant from the Larry L. Hillblom Foundation to examine aging across the life span, including age-related neurodegenerative diseases such as Alzheimer’s disease. The research will advance our understanding of aging mechanisms at the cognitive, genomic and cellular levels with potentially direct translatability to humans. Other members of the team include Salk President and Professor 鲁斯蒂·盖奇, Staff Scientist 尤里·马诺尔, Senior Staff Researcher Courtney Glavis-Bloom, and Carol Marchetto, an assistant professor at the University of California San Diego.
LA JOLLA—The Salk Institute will establish a world-class San Diego Nathan Shock Center (SD-NSC), a consortium with Sanford Burnham Prebys Medical Discovery Institute and the University of California San Diego (UC San Diego), to study cellular and tissue aging in humans. The Center will be funded by a grant from the National Institute on Aging (NIA) of the National Institutes of Health expected to total $5 million over the next 5 years (NIA grant number P30AG068635).
LA JOLLA—Salk scientists have used skin cells called fibroblasts from young and old patients to successfully create blood vessels cells that retain their molecular markers of age. The team’s approach, described in the journal eLife on September 8, 2020, revealed clues as to why blood vessels tend to become leaky and hardened with aging, and lets researchers identify new molecular targets to potentially slow aging in vascular cells.
拉霍亚—索尔克研究所的科学家们在追求安全有效的I型糖尿病治疗方法方面取得了重大进展。I型糖尿病影响着美国约160万人口，每年造成的经济损失高达$144亿美元。.
LA JOLLA—While your skeleton helps your body to move, fine skeleton-like filaments within your cells likewise help cellular structures to move. Now, Salk researchers have developed a new imaging method that lets them monitor a small subset of these filaments, called actin.
LA JOLLA—A drug candidate developed by Salk researchers, and previously shown to slow aging in brain cells, successfully reversed memory loss in a mouse model of inherited Alzheimer’s disease. The new research, published online in July 2020 in the journal Redox Biology, also revealed that the drug, CMS121, works by changing how brain cells metabolize fatty molecules known as lipids.
LA JOLLA—Due to the modern tendency to postpone childbirth until later in life, a growing number of women are experiencing issues with infertility. Infertility likely stems from age-related decline of the ovaries, but the molecular mechanisms that lead to this decline have been unclear. Now, scientists from the U.S. and China have discovered, in unprecedented detail, how ovaries age in non-human primates. The findings, published in 细胞 on January 30, 2020, reveal several genes that could be used as biomarkers and point to therapeutic targets for diagnosing and treating female infertility and age-associated ovarian diseases, such as ovarian cancer, in humans.
LA JOLLA—People with osteoarthritis, or “wear and tear” arthritis, have limited treatment options: pain relievers or joint replacement surgery. Now, Salk researchers have discovered that a powerful combination of two experimental drugs reverses the cellular and molecular signs of osteoarthritis in rats as well as in isolated human cartilage cells. Their results were published in the journal Protein & Cell on January 16, 2020.
拉霍亚——在阿尔茨海默病的小鼠模型中，被称为 CMS121 和 J147 的在研候选药物可以改善记忆力并减缓脑细胞的退化。现在，索尔克研究所的研究人员已经证明了这些化合物如何也能减缓健康老年小鼠的衰老，阻止大脑在衰老过程中发生的细胞损伤，并将特定分子的水平恢复到年轻大脑的水平。.
LA JOLLA—Metabolic syndrome affects nearly 30 percent of the U.S. population, and increases the risk for type 2 diabetes, heart disease and stroke. But lifestyle interventions such as adopting a healthy diet and increasing physical exercise are difficult to maintain and, even when combined with medication, are often insufficient to fully manage the disease.
LA JOLLA—Metformin is the most commonly prescribed type 2 diabetes drug, yet scientists still do not fully know how it works to control blood sugar levels. In a collaborative effort, researchers from the Salk Institute, The Scripps Research Institute and Weill Cornell Medical College have used a novel technology to investigate why it functions so well. The findings, which identified a surprising number of biochemical “switches” for various cellular processes, could also explain why metformin has been shown to extend health span and life span in recent studies. The work was published in 细胞报告 on December 3, 2019.
LA JOLLA—The ability to edit genes in living organisms offers the opportunity to treat a plethora of inherited diseases. However, many types of gene-editing tools are unable to target critical areas of DNA, and creating such a technology has been difficult as living tissue contains diverse types of cells.
LA JOLLA—Scientists once thought that neurons, or possibly heart cells, were the oldest cells in the body. Now, Salk Institute researchers have discovered that the mouse brain, liver and pancreas contain populations of cells and proteins with extremely long lifespans—some as old as neurons. The findings, demonstrating “age mosaicism,” were published in 细胞代谢 on June 6, 2019. The team’s methods could be applied to nearly any tissue in the body to provide valuable information about lifelong function of non-dividing cells and how cells lose control over the quality and integrity of proteins and important cell structures during aging.
LA JOLLA—Three Salk Institute faculty members have been promoted after the latest round of faculty reviews determined they are scientific leaders who have made original, innovative and notable contributions to biological research.
LA JOLLA—Doctors have long observed that biological age and chronological age are not always one and the same. A 55-year-old may exhibit many signs of old age and have numerous age-related diseases, whereas an 80-year-old may be healthy and robust. While diet, physical activity and other factors play a role, there are many contributors as to why and how some people age better than others. Those contributors remain poorly understood.
LA JOLLA—Old age is the greatest risk factor for many diseases, including Alzheimer’s disease (AD) and cancer. Geroprotectors are a recently identified class of anti-aging compounds. New Salk research has now identified a unique subclass of these compounds, dubbed geroneuroprotectors (GNPs), which are AD drug candidates and slow the aging process in mice.
LA JOLLA—A team of Salk Institute researchers led by President 鲁斯蒂·盖奇 has been awarded $19.2 million over eight years by the American Heart Association-Allen Initiative in Brain Health and Cognitive Impairment to investigate mechanisms underlying Alzheimer’s disease and aging-related cognitive decline and uncover new therapies. This bold venture will comprehensively analyze interactions between five areas key to brain health: proteins, genes, metabolism, inflammation and epigenetics.
拉霍亚胡安·卡洛斯·伊兹皮苏亚·贝尔蒙特, a professor in Salk’s Gene Expression Laboratory, has been named one of TIME magazine’s 50 most influential people in healthcare for his scientific innovations in addressing the shortage of human organs for transplant. The list, which is curated by TIME’s health reporters and editors, recognizes people who changed the state of healthcare in America this year, and bear watching for what they do next.
LA JOLLA—When we’re born, our brains have a great deal of flexibility. Having this flexibility to grow and change gives the immature brain the ability to adapt to new experiences and organize its interconnecting web of neural circuits. As we age, this quality, called "plasticity," lessens.
LA JOLLA—Plastic surgery to treat large cutaneous ulcers, including those seen in people with severe burns, bedsores or chronic diseases such as diabetes, may someday be a thing of the past. Scientists at the Salk Institute have developed a technique to directly convert the cells in an open wound into new skin cells. The approach relies on reprogramming the cells to a stem-cell-like state and could be useful for healing skin damage, countering the effects of aging and helping us to better understand skin cancer.
LA JOLLA—We’ve all heard the expression: “what doesn’t kill you makes you stronger.” Now, research led by a Salk Institute scientist suggests why, at a cellular level, this might be true. The team reports that brief exposures to stressors can be beneficial by prompting the cell to trigger sustained production of antioxidants, molecules that help get rid of toxic cellular buildup related to normal metabolism.
LA JOLLA—Defective energy production in old neurons might explain why our brains are so prone to age-related diseases. Salk researchers used a new method to discover that cells from older individuals had impaired mitochondria—the power stations of cells—and reduced energy production. A better understanding of the effects of aging on mitochondria could reveal more about the link between mitochondrial dysfunction and age-related brain diseases, such as Alzheimer's and Parkinson's.
拉霍亚—对于大多数血友病B患者来说，他们的身体无法正常形成血栓，因此需要持续注射来补充凝血因子，这已成为他们生活的一部分。但现在，索尔克研究所的研究人员在小鼠身上进行的实验表明，通过一次性的注射含有能够产生缺失凝血因子的无病肝细胞，就可以终身治疗血友病B。这项发现发表在《 细胞报告 2018年5月1日，这项研究可能彻底改变血友病B的诊断意义，并为治疗其他相关遗传性疾病铺平道路。.
拉霍亚——在危及生命的时刻，我们依靠消防员保护我们。因此，让他们保持健康和强壮符合每个人的最大利益。霍华德休斯医学研究所和加州大学圣地亚哥医学院的研究人员获得了$国土安全部提供的 150 万美元赠款，用于一项为期三年的研究，以评估将进食时间限制在 10 小时内是否能改善消防员的福祉。.
LA JOLLA—Potentially explaining why even healthy brains don’t function well with age, Salk researchers have discovered that genes that are switched on early in brain development to sever connections between neurons as the brain fine-tunes, are again activated in aging neuronal support cells called astrocytes. The work, which appeared in 细胞报告 on January 2, 2018, suggests that astrocytes may be good therapeutic targets to prevent or reverse the effects of normal aging.
LA JOLLA—The experimental drug J147 is something of a modern elixir of life; it’s been shown to treat Alzheimer’s disease and reverse aging in mice and is almost ready for clinical trials in humans. Now, Salk scientists have solved the puzzle of what, exactly, J147 does. In a paper published January 7, 2018, in the journal Aging Cell, they report that the drug binds to a protein found in mitochondria, the energy-generating powerhouses of cells. In turn, they showed, it makes aging cells, mice and flies appear more youthful.
LA JOLLA—Like an actor who excels at both comedy and drama, proteins also can play multiple roles. Uncovering these varied talents can teach researchers more about the inner workings of cells. It also can yield new discoveries about evolution and how proteins have been conserved across species over hundreds of millions of years.
LA JOLLA—The process by which embryonic stem cells develop into heart cells is a complex process involving the precisely timed activation of several molecular pathways and at least 200 genes. Now, Salk Institute scientists have found a simpler way to go from stem cells to heart cells that involves turning off a single gene.
LA JOLLA—Every day, websites you visit and smartphone apps that you use are crunching huge sets of data to find things that resemble each other: products that are similar to your past purchases; songs that are similar to tunes you’ve liked; faces that are similar to people you’ve identified in photos. All these tasks are known as similarity searches, and the ability to perform these massive matching games well—and fast—has been an ongoing challenge for computer scientists.
LA JOLLA—It may seem paradoxical, but studying what goes wrong in rare diseases can provide useful insights into normal health. Researchers probing the premature aging disorder Hutchinson-Gilford progeria have uncovered an errant protein process in the disease that could help healthy people as well as progeria sufferers live longer.
LA JOLLA—Scientists have, for the first time, corrected a disease-causing mutation in early stage human embryos with gene editing. The technique, which uses the CRISPR-Cas9 system, corrected the mutation for a heart condition at the earliest stage of embryonic development so that the defect would not be passed on to future generations.
LA JOLLA—(May 4, 2017) Salk Institute scientists have developed a novel technology to correct disease-causing aberrations in the chemical tags on DNA that affect how genes are expressed. These types of chemical modifications, collectively referred to as epigenetics or the epigenome, are increasingly being considered as important as the genomic sequence itself in development and disease.
LA JOLLA—The Salk Institute has received a $3 million award from the 格伦医学研究基金会 for the second time in 4 years, enabling the Institute to continue investigating the biology of normal human aging and age-related diseases.
LA JOLLA—When scientists talk about laboratory stem cells being totipotent or pluripotent, they mean that the cells have the potential, like an embryo, to develop into any type of tissue in the body. What totipotent stem cells can do that pluripotent ones can’t do, however, is develop into tissues that support the embryo, like the placenta. These are called extra-embryonic tissues, and are vital in development and healthy growth.
LA JOLLA—Rapid advances in the ability to grow cells, tissues and organs of one species within an organism of a different species offer an unprecedented opportunity for tackling longstanding scientific mysteries and addressing pressing human health problems, particularly the need for transplantable organs and tissues.
LA JOLLA—Graying hair, crow’s feet, an injury that’s taking longer to heal than when we were 20—faced with the unmistakable signs of aging, most of us have had a least one fantasy of turning back time. Now, scientists at the Salk Institute have found that intermittent expression of genes normally associated with an embryonic state can reverse the hallmarks of old age.
LA JOLLA—Ever since researchers connected the shortening of telomeres—the protective structures on the ends of chromosomes—to aging and disease, the race has been on to understand the factors that govern telomere length. Now, scientists at the Salk Institute have found that a balance of elongation and trimming in stem cells results in telomeres that are, as Goldilocks would say, not too short and not too long, but just right.
LA JOLLA—Salk Institute researchers have discovered a holy grail of gene editing—the ability to, for the first time, insert DNA at a target location into the non-dividing cells that make up the majority of adult organs and tissues. The technique, which the team showed was able to partially restore visual responses in blind rodents, will open new avenues for basic research and a variety of treatments, such as for retinal, heart and neurological diseases.
LA JOLLA—We put things into a container to keep them organized and safe. In cells, the nucleus has a similar role: keeping DNA protected and intact within an enveloping membrane. But a new study by Salk Institute scientists, detailed in the November 2 issue of Genes & Development, reveals that this cellular container acts on its contents to influence gene expression.
LA JOLLA—Boosting levels of a specific protein in the brain alleviates hallmark features of Alzheimer’s disease in a mouse model of the disorder, according to new research published online August 25, 2016 in Scientific Reports.
LA JOLLA—When you reach for that pan of brownies, a ball-shaped brain structure called the striatum is critical for controlling your movement toward the reward. A healthy striatum also helps you stop yourself when you’ve had enough.
LA JOLLA—For decades, scientists have known that people with two copies of a gene called apolipoprotein E4 (ApoE4) are much more likely to have 阿尔茨海默病 at age 65 than the rest of the population. Now, researchers at the Salk Institute have identified a new connection between ApoE4 and protein build-up associated with Alzheimer’s that provides a possible biochemical explanation for how extra ApoE4 causes the disease.
LA JOLLA—Salk scientists and colleagues have proposed new molecular criteria for judging just how close any line of laboratory-generated stem cells comes to mimicking embryonic cells seen in the very earliest stages of human development, known as naïve stem cells. The tests found that no current protocols lead to truly naïve stem cells, but the guidelines may help researchers achieve that goal by pointing out where each current method falls short. Generating naïve stem cells would be a boon to both basic research and to medical applications of stem cells, such as growing tissue for organ replacement.
LA JOLLA—Chronic damage to the liver eventually creates a wound that never heals. This condition, called fibrosis, gradually replaces normal liver cells—which detoxify the food and liquid we consume—with more and more scar tissue until the organ no longer works.
LA JOLLA–Healthy brain, muscle, eye and heart cells would improve the lives of tens of thousands of people around the world with debilitating mitochondrial diseases. Now, researchers at the Salk Institute have gotten one step closer to making such cures a reality: they’ve turned cells from patients into healthy, mutation-free stem cells that can then become any cell type. The new approach is described July 15, 2015 in 自然.
LA JOLLA–Bread, cereal and other sugary processed foods cause rapid spikes and subsequent crashes in blood sugar. In contrast, diets made up of vegetables, fruits and whole grains are healthier, in part because they take longer to digest and keep us more even-keeled.
LA JOLLA–Scientists at the Salk Institute have discovered a novel type of pluripotent stem cell–cells capable of developing into any type of tissue–whose identity is tied to their location in a developing embryo. This contrasts with stem cells traditionally used in scientific study, which are characterized by their time-related stage of development.
LA JOLLA–Stem cells, which have the potential to turn into any kind of cell, offer the tantalizing possibility of generating new tissues for organ replacements, stroke victims and patients of many other diseases. Now, scientists at the Salk Institute have uncovered details about stem cell growth that could help improve regenerative therapies.
LA JOLLA–A study tying the aging process to the deterioration of tightly packaged bundles of cellular DNA could lead to methods of preventing and treating age-related diseases such as cancer, diabetes and Alzheimer’s disease, as detailed April 30, 2015, in 科学.
LA JOLLA–Just as some people seem built to run marathons and have an easier time going for miles without tiring, others are born with a knack for memorizing things, from times tables to trivia facts. These two skills–running and memorizing–are not so different as it turns out.
LA JOLLA–Researchers at the Salk Institute have healed injured hearts of living mice by reactivating long dormant molecular machinery found in the animals’ cells, a finding that could help pave the way to new therapies for heart disorders in humans.
LA JOLLA–Scientists at the Salk Institute have discovered an on-and-off “switch” in cells that may hold the key to healthy aging. This switch points to a way to encourage healthy cells to keep dividing and generating, for example, new lung or liver tissue, even in old age.
LA JOLLA—For the first time, scientists have turned human skin cells into transplantable white blood cells, soldiers of the immune system that fight infections and invaders. The work, done at the Salk Institute, could let researchers create therapies that introduce into the body new white blood cells capable of attacking diseased or cancerous cells or augmenting immune responses against other disorders.
LA JOLLA–Scientists at the Salk Institute for Biological Studies have identified a gene that regulates sleep and wake rhythms.
LA JOLLA—Frogs, dogs, whales, snails can all do it, but humans and primates can’t. Regrow nerves after an injury, that is—while many animals have this ability, humans don’t. But new research from the Salk Institute suggests that a small molecule may be able to convince damaged nerves to grow and effectively rewire circuits. Such a feat could eventually lead to therapies for the thousands of Americans with severe spinal cord injuries and paralysis.
LA JOLLA—For hundreds of years, healers in São Tomé e Príncipe—an island off the western coast of Africa—have prescribed cata-manginga leaves and bark to their patients. These pickings from the Voacanga africana tree are said to decrease inflammation and ease the symptoms of mental disorders.
LA JOLLA—Researchers around the world have turned to stem cells, which have the potential to develop into any cell type in the body, for potential regenerative and disease therapeutics.
LA JOLLA—The Salk Institute has received a $3 million gift from the 格伦医学研究基金会 to allow the Institute to continue conducting research to understand the biology of normal human aging and age-related diseases.
LA JOLLA—Using reprogrammed skin cells, researchers have for the first time used stem cell techniques to grow fully functional assemblies of the cells that line airways leading to the lungs. The lab-grown airway tissue can now be used to study the molecular basis for lung diseases—from rare genetic disorders to common afflictions like asthma and emphysema—and test new drugs to treat the diseases.
拉霍亚维姬·伦德布拉德, professor of the Salk Institute’s Molecular and Cell Biology Laboratory, has been awarded the Becky and Ralph S. O’Connor Chair and elected a Fellow of the American Academy of Microbiology.
LA JOLLA, CA—Diseases affecting the kidneys represent a major and unsolved health issue worldwide. The kidneys rarely recover function once they are damaged by disease, highlighting the urgent need for better knowledge of kidney development and physiology.
拉霍亚，加利福尼亚州—Alzheimer’s disease affects more than 26 million people worldwide. It is predicted to skyrocket as boomers age—nearly 106 million people are projected to have the disease by 2050. Fortunately, scientists are making progress towards therapies. A collaboration among several research entities, including the Salk Institute and the Sanford-Burnham Medical Research Institute, has defined a key mechanism behind the disease’s progress, giving hope that a newly modified Alzheimer’s drug will be effective.
LA JOLLA, CA—Proteins are the chief actors in cells, carrying out the duties specified by information encoded in our genes. Most proteins live only two days or less, ensuring that those damaged by inevitable chemical modifications are replaced with new functional copies.
LA JOLLA, CA—Stem cells are key to the promise of regenerative medicine: the repair or replacement of injured tissues with custom grown substitutes. Essential to this process are induced pluripotent stem cells (iPSCs), which can be created from a patient’s own tissues, thus eliminating the risk of immune rejection. However, Shinya Yamanaka’s formula for iPSCs, for which he was awarded last year’s Nobel Prize, uses a strict recipe that allows for limited variations in human cells, restricting their full potential for clinical application.
LA JOLLA,CA—A team of scientists at the Salk Institute for Biological Studies has identified why disruption of a vital pathway in cell cycle control leads to the proliferation of cancer cells. Their findings on telomeres, the stretches of DNA at the ends of chromosomes that protect our genetic code and make it possible for cells to divide, suggest a potential target for preventive measures against cancer, aging and other diseases. The findings were published July 11, 2013 in Molecular Cell.
加拉霍亚，加利福尼亚州——表观基因组的变化，包括 DNA 的化学修饰，可以作为基因组中的额外信息层，并被认为在学习和记忆以及与年龄相关的认知能力下降中起作用。美国索尔克生物学研究所科学家的一项新研究结果表明，DNA 甲基化（一种特殊的表观基因组修饰）的景观在从出生到成年的过渡过程中，在大脑细胞中具有高度动态性，有助于理解大脑细胞基因组中的信息是如何从胎儿发育到成年的。大脑比身体所有其他器官都要复杂得多，这一发现为更深入地了解大脑中复杂的连接模式是如何形成的打开了大门。.
LA JOLLA, CA—A drug developed by scientists at the Salk Institute for Biological Studies, known as J147, reverses memory deficits and slows Alzheimer’s disease in aged mice following short-term treatment. The findings, published May 14 in the journal Alzheimer’s Research and Therapy, may pave the way to a new treatment for Alzheimer’s disease in humans.
LA JOLLA, CA—Scientists have long known that control mechanisms known collectively as “epigenetics” play a critical role in human development, but they did not know precisely how alterations in this extra layer of biochemical instructions in DNA contribute to development.
LA JOLLA, CA—For humans to grow and to replace and heal damaged tissues, the body’s cells must continually reproduce, a process known as “cell division,” by which one cell becomes two, two become four, and so on. A key question of biomedical research is how chromosomes, which are duplicated during cell division so that each daughter cell receives an exact copy of a person’s genome, are arranged during this process.
加州拉霍亚——一种从成熟细胞生成干细胞的新方法有望提高实验室中干细胞的产量，有助于清除再生医学疗法的一个障碍，该疗法将取代受损或不健康的身体组织。.
LA JOLLA, CA—Growing evidence suggests that there may be a link between 糖尿病 和 Alzheimer’s disease, but the physiological mechanisms by which diabetes impacts brain function and cognition are not fully understood. In a new study published in Aging Cell, researchers at the Salk Institute for Biological Studies show, for the first time, that diabetes enhances the development of aging features that may underlie early pathological events in Alzheimer’s.
加利福尼亚州拉霍亚—通过对患有已知基因突变的帕金森病患者的皮肤细胞进行重新编程，索尔克生物研究所的研究人员发现，神经干细胞的损伤在该疾病中扮演着重要角色。这项研究结果于 2013 年 10 月 17 日在线发布于 自然, 可能带来诊断和治疗该疾病的新方法。.
LA JOLLA, CA—Based on two new studies by researchers at the Salk Institute for Biological Studies, regeneration of a new limb or organ in a human will be much more difficult than the mad scientist and supervillain, Dr. Curt Connors, made it seem in the Amazing Spider-man comics and films.
LA JOLLA, CA—Salk scientists have identified a unique molecular signature in induced pluripotent stem cells (iPSCs), “reprogrammed” cells that show great promise in regenerative medicine thanks to their ability to generate a range of body tissues.
LA JOLLA, CA—The Salk Institute is pleased to announce that professors E.J. Chichilnisky, 扬·卡尔塞德, ，和 李郭芬 have each been selected as the recipient of an endowed chair to honor their consistent scientific excellence and support their biological research.
LA JOLLA, CA—With their potential to treat a wide range of diseases and uncover fundamental processes that lead to those diseases, embryonic stem (ES) cells hold great promise for biomedical science. A number of hurdles, both scientific and non-scientific, however, have precluded scientists from reaching the holy grail of using these special cells to treat heart disease, diabetes, Alzheimer’s and other diseases.
LA JOLLA, CA—Stem cells are essential building blocks for all organisms, from plants to humans. They can divide and renew themselves throughout life, differentiating into the specialized tissues needed during development, as well as cells necessary to repair adult tissue.
LA JOLLA, CA—One of the big mysteries in biology is why cells age. Now scientists at the Salk Institute for Biological Studies report that they have discovered a weakness in a component of brain cells that may explain how the aging process occurs in the brain.
LA JOLLA, CA—Scientists at the Salk Institute for Biological Studies have identified a gene that tells cells to develop multiple cilia, tiny hair-like structures that move fluids through the lungs and brain. The finding may help scientists generate new therapies that use stem cells to replace damaged tissues in the lung and other organs.
LA JOLLA, CA—A new drug candidate may be the first capable of halting the devastating mental decline of Alzheimer's disease, based on the findings of a study published in PLoS ONE.
LA JOLLA, CA—Researchers at the Salk Institute for Biological Studies have developed a way to use patients’ own cells to potentially cure sickle cell disease and many other disorders caused by mutations in a gene that helps produce blood hemoglobin.
LA JOLLA, CA—An international team of scientists has created super-strong, high-endurance mice and worms by suppressing a natural muscle-growth inhibitor, suggesting treatments for age-related or genetics-related muscle degeneration are within reach.
LA JOLLA, CA—The Salk Institute is pleased to announce the appointment of five faculty members to be recipients of endowed chairs established by philanthropic leaders in support of scientific research.
LA JOLLA, CA—One of the few reliable ways to extend an organism’s lifespan, be it a fruit fly or a mouse, is to restrict calorie intake. Now, a new study in fruit flies is helping to explain why such minimal diets are linked to longevity and offering clues to the effects of aging on stem cell behavior.
