Ronald Evans

Professor and Director

Gene Expression Laboratory

Howard Hughes Medical Institute Investigator

March of Dimes Chair in Molecular and Developmental Biology

Ronald Evans
Salk Institute for Biological Studies - News

News


Immune cell policing offers insights into cancer, autoimmune disease

LA JOLLA—Regulatory T cells (Tregs) are the traffic cops of the immune system. They instruct other types of immune cells on when to stop and when to go. Learning how …


Salk researchers awarded $2.5 million for innovative pancreatic cancer clinical trial

LA JOLLA—Salk Professor and HHMI Investigator Ronald Evans has been awarded $2.5 million by Stand Up To Cancer (SU2C) as part of a multi-institution team to conduct clinical studies to …


“Exercise-in-a-pill” boosts athletic endurance by 70 percent

LA JOLLA—Every week, there seems to be another story about the health benefits of running. That’s great—but what if you can’t run? For the elderly, obese or otherwise mobility-limited, the …


Pancreatic tumors rely on signals from surrounding cells

Tumor cells stained with a marker for cancer (green) appear near stromal cells (red).

Click here for a high-resolution image

Credit: Salk Institute

LA JOLLA—Just as an invasive weed might …


Powering up the circadian rhythm

LA JOLLA—At noon every day, levels of genes and proteins throughout your body are drastically different than they are at midnight. Disruptions to this 24-hour cycle of physiological activity are …


Salk scientists find “secret sauce” for personalized, functional insulin-producing cells

LA JOLLA—Salk scientists have solved a longstanding problem in the effort to create replacement cells for diabetic patients. The team uncovered a hidden energy switch that, when flipped, powers up …


Fighting liver fibrosis, the wound that never heals

LA JOLLA—Chronic damage to the liver eventually creates a wound that never heals. This condition, called fibrosis, gradually replaces normal liver cells—which detoxify the food and liquid we consume—with more …


Blocking immune cell treats new type of age-related diabetes

LA JOLLA—Diabetes is often the result of obesity and poor diet choices, but for some older adults the disease might simply be a consequence of aging. New research has discovered that …


Salk professor Ron Evans to co-lead ‘Dream Team’ of pancreatic cancer researchers from US, UK

LA JOLLA, CA—The Salk Institute will co-lead a new transatlantic ‘Dream Team’ of researchers that will launch a fresh attack on pancreatic cancer, one of the deadliest forms of cancer …


A high-fat diet may alleviate mitochondrial disease

LA JOLLA–Mice that have a genetic version of mitochondrial disease can easily be mistaken for much older animals by the time they are nine months old: they have thinning grey …


Food for thought: Master protein enhances learning and memory

LA JOLLA–Just as some people seem built to run marathons and have an easier time going for miles without tiring, others are born with a knack for memorizing things, from …


“Imaginary meal” tricks the body into losing weight

LA JOLLA–Salk researchers have developed an entirely new type of pill that tricks the body into thinking it has consumed calories, causing it to burn fat. The compound effectively stopped …


Modified vitamin D shows promise as treatment for pancreatic cancer

LA JOLLA–A synthetic derivative of vitamin D was found by Salk Institute researchers to collapse the barrier of cells shielding pancreatic tumors, making this seemingly impenetrable cancer much more susceptible …


One injection stops diabetes in its tracks

LA JOLLA—In mice with diet-induced diabetes—the equivalent of type 2 diabetes in humans—a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range …


Salk professor named grantee in new pancreatic cancer research program

LA JOLLA—Ronald M. Evans, director of the Gene Expression Laboratory at Salk and Howard Hughes Medical Institute investigator, is one of three scientists chosen to receive $5 million in research …


Salk Education Outreach program wins AAAS grant

LA JOLLA—The Salk Institute’s award-winning Education Outreach program recently earned national recognition when it received a two-year pilot grant through the AAAS’s new National STEM (Science, Technology, Engineering and Math) …


Salk scientists find potential therapeutic target for Cushing’s disease

LA JOLLA, CA—Scientists at the Salk Institute for Biological Studies have identified a protein that drives the formation of pituitary tumors in Cushing’s disease, a development that may give clinicians …


Sunshine hormone, vitamin D, may offer hope for treating liver fibrosis

LA JOLLA, CA—Liver fibrosis results from an excessive accumulation of tough, fibrous scar tissue and occurs in most types of chronic liver diseases. In industrialized countries, the main causes of …


Canker sore drug may aid in weight loss

LA JOLLA, CA—A team of scientists, including researchers from the Salk Institute for Biological Studies, has discovered that a drug used to treat canker sores appears to reverse obesity in …


From feast to famine: A metabolic switch that may help diabetes treatment

LA JOLLA, CA—Humans are built to hunger for fat, packing it on during times of feast and burning it during periods of famine. But when deluged by foods rich in …


Salk scientists redraw the blueprint of the body’s biological clock

LA JOLLA, CA—The discovery of a major gear in the biological clock that tells the body when to sleep and metabolize food may lead to new drugs to treat sleep …


Salk scientist Ronald M. Evans wins 2012 Wolf Prize in Medicine

LA JOLLA, CA—Salk Institute scientist Ronald Evans has been selected as the recipient of the prestigious 2012 Wolf Prize in Medicine, Israel’s highest award for achievements benefiting mankind. According to …


Tweaking a gene makes muscles twice as strong

LA JOLLA, CA—An international team of scientists has created super-strong, high-endurance mice and worms by suppressing a natural muscle-growth inhibitor, suggesting treatments for age-related or genetics-related muscle degeneration are within …


Salk breathes new life into fight against primary killer of premature infants

LA JOLLA, CA—A discovery by scientists at the Salk Institute for Biological Studies might explain why some premature infants fail to respond to existing treatments for a deadly respiratory distress …


Scientists discover genetic switch that increases muscle blood supply

LA JOLLA, CA—Many people suffer from a devastating condition known as critical limb ischemia (CLI) that can lead to muscle wasting and even amputation. The disease is linked to …


The food-energy cellular connection revealed: Metabolic master switch sets the biological clock in body tissues

LA JOLLA, CA—Our body’s activity levels fall and rise to the beat of our internal drums-the 24-hour cycles that govern fundamental physiological functions, from sleeping and feeding patterns to the …


Exercise in a pill

LA JOLLA, CA—Trying to reap the health benefits of exercise? Forget treadmills and spin classes, researchers at the Salk Institute for Biological Studies may have found a way around the …


New potential drug target for the treatment of atherosclerosis

La Jolla, CA – A nuclear receptor protein, known for controlling the ability of cells to burn fat, also exerts powerful anti-inflammatory effects in arteries, suppressing atherosclerosis in mice prone …


Salk researchers uncover molecular connection between excessive nutrient levels and insulin resistance

La Jolla, CA – For quite some time now, scientists suspected the so-called hexosamine pathway – a small side business of the main sugar processing enterprise inside a cell – …


Newborn brain cells modulate learning and memory

La Jolla, CA – Boosted by physical and mental exercise, neural stem cells continue to sprout new neurons throughout life, but the exact function of these newcomers has been the …


Regulator of lipid metabolism ensures high quality breast milk

La Jolla, CA – Mouse mammary glands deficient in PPARγ, a nuclear receptor that regulates the storage of fat, produce toxic milk that causes inflammation and baldness in suckling pups, …


Salk Scientist Ronald M. Evans Receives America’s Top Prize in Medicine

La Jolla, CA – Ronald M. Evans, Ph.D., Professor in the Salk Institute’s Gene Expression Laboratory and a Howard Hughes Medical Investigator, has been named a recipient of …


Ronald M. Evans to receive Harvey Prize for outstanding contributions to human health

La Jolla, CA – Dr. Ronald M. Evans, professor and head of the Gene Expression Laboratory of the Salk Institute for Biological Studies, was awarded the …


Salk scientist Ron Evans wins 2006 Gairdner Award for his discovery of hormone sensors

La Jolla, CA – Ronald M. Evans, Ph.D., professor and head of the Gene Expression Laboratory of the Salk Institute for Biological Studies, has …


Genetically modified mice are resistant to obesity despite a high fat diet

La Jolla, CA – Ravenous mice that chomp down as if there were no tomorrow yet stay lean and mean? Shutting down two genes that modulate a body’s energy balance …


Salk scientist awarded Glenn T. Seaborg Medal

La Jolla, CA – Ronald M. Evans, Ph.D., who during his 27 years of research at the Salk Institute has made major discoveries about how hormones and drugs control the …


France’s highest scientific honor to be awarded this year to Salk Institute scientist Ronald M. Evans

La Jolla, CA – Ronald M. Evans, Ph.D., professor and head of the Gene Expression Laboratory of the Salk Institute for Biological Studies, will receive the 2005 Grande Médaille D’Or …


Altering steroid receptor genes creates fat burning muscles, resistance to weight gain, and lowered inflammation.

La Jolla, CA – The Salk Institute scientist who earlier discovered that enhancing the function of a single protein produced a mouse with an innate resistance to weight gain and …


Salk Institute’s Ronald M. Evans Awarded 2004 Lasker Award For Basic Medical Research

La Jolla, CA – Ronald M. Evans, Ph.D. known for his discoveries of genetic switches that link hormones to gene control, is this year’s recipient of the highly prestigious 2004 …


Marathoning Mice Could Have Olympian Effects on Obesity

La Jolla, CA – A molecular switch known to regulate fat metabolism appears to prevent obesity and turns laboratory mice into marathon runners, a Salk Institute study has found.

The discovery …


Stem Cell Regulator Could Hold Key to Staving Off Age-related Brain Changes

La Jolla, CA – A brain-specific genetic switch protein known as a receptor has been found to control the fate of adult stem cells in the brain, according to a …


Salk Researcher named to Institute of Medicine

La Jolla, CA – Ronald Evans, the March of Dimes Chair in Developmental and Cell Biology at the Salk Institute, was named to the Institute of Medicine (IOM). Part of …


Cellular Fat Sensor Slows Heart Disease

La Jolla, CA – A cellular sensor of dietary fats slows the development of lesions that lead to heart disease, a Salk Institute study has found.

The study, which appears in …


Salk Researchers Ranked in Top 25 of Scientific Citations Worldwide

La Jolla, CA – Two Salk Institute researchers ranked within the top 25 scientists worldwide for their work’s influence in any field, according to an organization that monitors the impact …


Salk Professor Ronald Evans Awarded Two Major Prizes

La Jolla, CA – Professor Ronald Evans, the March of Dimes Chair in Molecular and Developmental Biology, has received the 2003 March of Dimes Prize in Developmental Biology for his …


Salk Researchers Find Receptor That Controls Obesity

La Jolla, CA – A cellular receptor that balances the accumulation of fat and fat burning in the body may be a new target for anti-obesity and cholesterol-fighting drugs, according …


Vitamin A Deficiency Impairs Learning Functions In Reversible Manner

La Jolla, CA – Removing Vitamin A from the diets of mice diminishes chemical changes in the brain considered the hallmarks of learning and memory. When vitamin A is added …


Humanized Mouse To Become Basic Tool To Test Drug-Drug Interactions

La Jolla, CA – A genetically engineered mouse, equipped with a human gene that senses potentially toxic substances in the body, including drugs, has been created by scientists at The …


Link between vitamin A and learning abilities established by team led by Salk researchers

La Jolla, CA – Forget something lately? If so, perhaps you should try an extra helping of sweet potatoes or other vitamin A-rich foods on the holiday table.

Researchers at the …


New steroid hormone has allure of its own

La Jolla, CA – The first steroid hormone unearthed in 30 years is a chemical cousin to the molecule that lures pigs to truffles, and like that rare and elusive …


Salk scientists identify molecular link between dietary fat and colon cancer

La Jolla, CA – Although it’s now common wisdom that dietary fat is related to some cancers, medical researchers have not understood the underlying mechanisms. In research reported in the …


Salk researchers find genetic feedback loop implicated in the early events of atherosclerotic plaque formation

La Jolla, CA – Salk Institute scientists today announced two research findings related to the development of atherosclerosis. The findings involve the discovery of a genetic feedback loop that contributes …


Education

BA, Bacteriology, University of California, Los Angeles
PhD, Microbiology and Immunology, University of California, Los Angeles
Postdoctoral Fellow, Rockefeller University


Awards & Honors

  • 2013 Dale Medal, Society for Endocrinology, UK
  • 2012 Wolf Prize in Medicine
  • 2006 Harvey Prize in Human Health
  • 2005 Glenn T. Seaborg Medal
  • 2005 Grande Médaille D'Or of France
  • 2004 Albert Lasker Award for Basic Medical Research
  • 2003 National Academy of Medicine
  • 1997 Institute for Scientific Information most cited researcher
  • 1994 California Scientist of the Year
  • 1989 National Academy of Sciences
  • 1985 Howard Hughes Medical Institute Investigator

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