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Salk News

New kinds of brain cells revealed

LA JOLLA—Under a microscope, it can be hard to tell the difference between any two neurons, the brain cells that store and process information. So scientists have turned to molecular methods to try to identify groups of neurons with different functions.

Salk neuroscientist receives new NSF award to model the brain

LA JOLLA—As part of the National Science Foundation’s funding for new multidisciplinary approaches to neuroscience, Salk Professor Terrence Sejnowski together with the California Institute of Technology will receive over $1 million over 3 years to pursue advanced modeling of the brain.

Early gene-editing success holds promise for preventing inherited diseases

LA JOLLA—Scientists have, for the first time, corrected a disease-causing mutation in early stage human embryos with gene editing. The technique, which uses the CRISPR-Cas9 system, corrected the mutation for a heart condition at the earliest stage of embryonic development so that the defect would not be passed on to future generations.

Salk teams part of new effort to advance understanding of brain structure

LA JOLLA—Two Salk neuroscience labs are part of a National Science Foundation (NSF) effort to better understand the brain. Salk Professors Terrence Sejnowski and Ed Callaway are each collaborators in multi-institute projects awarded over $9 million apiece.

Salk Institute scientist Reuben Shaw receives National Cancer Institute Outstanding Investigator Award

LA JOLLA—Salk Professor Reuben Shaw has received the National Cancer Institute (NCI) Outstanding Investigator Award (OIA), which encourages cancer research with breakthrough potential. Shaw, a member of Salk’s Molecular and Cell Biology Laboratory and holder of the William R. Brody Chair, will receive $4.2 million in direct funding over the next seven years to further his work. The award is granted, according to the NCI website, to innovative cancer researchers with outstanding records of productivity to allow them to take greater risks and be more adventurous in their research.

Salk scientists solve longstanding biological mystery of DNA organization

LA JOLLA—Stretched out, the DNA from all the cells in our body would reach Pluto. So how does each tiny cell pack a two-meter length of DNA into its nucleus, which is just one-thousandth of a millimeter across?

How plant architectures mimic subway networks

LA JOLLA—It might seem like a tomato plant and a subway system don’t have much in common, but both, it turns out, are networks that strive to make similar tradeoffs between cost and performance.

More evidence shows natural plant compound may reduce mental effects of aging

LA JOLLA—Salk scientists have found further evidence that a natural compound in strawberries reduces cognitive deficits and inflammation associated with aging in mice. The work, which appeared in the Journals of Gerontology Series A in June 2017, builds on the team’s previous research into the antioxidant fisetin, finding it could help treat age-related mental decline and conditions like Alzheimer’s or stroke.

How plants grow like human brains

LA JOLLA—Plants and brains are more alike than you might think: Salk scientists discovered that the mathematical rules governing how plants grow are similar to how brain cells sprout connections. The new work, published in Current Biology on July 6, 2017, and based on data from 3D laser scanning of plants, suggests there may be universal rules of logic governing branching growth across many biological systems.

Tilted microscopy technique better reveals protein structures

LA JOLLA—The conventional way of placing protein samples under an electron microscope during cryo-EM experiments may fall flat when it comes to getting the best picture of a protein’s structure. In some cases, tilting a sheet of frozen proteins—by anywhere from 10 to 50 degrees—as it lies under the microscope, gives higher quality data and could lead to a better understanding of a variety of diseases, according to new research led by Salk scientist Dmitry Lyumkis.

Getty Conservation Institute and Salk Institute announce completion of major conservation efforts

LA JOLLA-The Getty Conservation Institute (GCI) and Salk Institute for Biological Studies announced today that after four years, conservation efforts are complete for one of the key architectural elements at the Salk Institute in La Jolla, California—its teak window walls. The site, completed in 1965 and designed by famed architect Louis I. Kahn, is widely considered to be a masterpiece of modern architecture. It is also home to globally renowned scientists making breakthroughs in areas of cancer, neuroscience, metabolism, plant science, genetics, and more.

Salk Institute establishes architecture endowment

LA JOLLA—The Institute announces today the launch of the Architecture Conservation Program, designed to address ongoing preservation of the nearly 60-year-old Modernist structure considered to be a masterwork of American architect Louis Kahn.

New method to rapidly map the “social networks” of proteins

LA JOLLA—Salk scientists have developed a new high-throughput technique to determine which proteins in a cell interact with each other. Mapping this network of interactions, or “interactome,” has been slow going in the past because the number of interactions that could be tested at once was limited. The new approach, published June 26 in Nature Methods, lets researchers test millions of relationships between thousands of proteins in a single experiment.

Prominent scientists in immunobiology and aging research to join Salk Institute

LA JOLLA—The Salk Institute is honored to welcome two new faculty with the rank of full professor, both of whom are highly respected and accomplished leaders in their fields. Susan Kaech and Gerald Shadel will inspire fresh collaborations and bring experienced perspectives to bear on Salk’s approaches to health and disease.

Grammy legend David Foster & Friends headline at 22nd Symphony at Salk

LA JOLLA—The Salk Institute will celebrate 22 years of Symphony at Salk, its signature concert under the stars, with Grammy-winning songwriter, composer and producer David Foster and the incomparable San Diego Symphony on Saturday, August 26.

Salk Institute scientist Eiman Azim named Pew Scholar and Aging Brain Scholar

LA JOLLA—The Pew Charitable Trusts announced today that Eiman Azim, an assistant professor in Salk’s Molecular Neurobiology Laboratory, is one of 22 researchers to be named a Pew Scholar in the Biomedical Sciences. Each scholar receives $240,000 over four years. Additionally, Azim is one of a subset of five Pew Scholars selected for support by the Kathryn W. Davis Peace by Pieces Fund, which focuses on investigating health challenges in the brain as it ages.

How the brain recognizes what the eye sees

LA JOLLA—If you think self-driving cars can’t get here soon enough, you’re not alone. But programming computers to recognize objects is very technically challenging, especially since scientists don’t fully understand how our own brains do it.

Salk’s Waitt Advanced Biophotonics Center partners with imaging giant ZEISS

LA JOLLA—The Salk Institute’s Waitt Advanced Biophotonics Center and ZEISS announced today a global partnership to accelerate the frontiers of microscopy and imaging technologies.

How cells divide tasks and conquer work

LA JOLLA—Despite advances in neuroscience, the brain is still very much a black box—no one even knows how many different types of neurons exist. Now, a scientist from the Salk Institute has used a mathematical framework to better understand how different cell types divide work among themselves.

A star is born: lesser-known brain cell takes center stage

LA JOLLA—Neurons have long enjoyed the spotlight in neuroscience—and for good reason: they are incredibly important cellular actors. But, increasingly, star-shaped support cells called astrocytes are being seen as more than bit players in the brain’s rich pageant.