LA JOLLA—The metabolic protein AMPK has been described as a kind of magic bullet for health. Studies in animal models have shown that compounds that activate the protein have health-promoting effects to reverse diabetes, improve cardiovascular health, treat mitochondrial disease—even extend life span. However, how much of the effects of these compounds can be fully attributed to AMPK versus other potential targets is unknown.
LA JOLLA—Salk scientist Saket Navlakha has received a CAREER award from the National Science Foundation (NSF) totaling more than $1 million over the next five years. The CAREER award supports faculty who exemplify the role of teacher/scholars through outstanding research, excellent education and the integration of education and research within the context of the mission of their organizations.
LA JOLLA—Autism spectrum disorder (ASD) is a relatively common developmental disorder of communication and behavior that affects about 1 in 59 children in the US, according to the Centers for Disease Control and Prevention. Despite its prevalence, it is still unclear what causes the disease and what are the best ways to treat it.
LA JOLLA—The Board of Trustees of the Salk Institute, in consultation with the faculty and a search committee comprised of Board members, voted to extend a new five-year term to Rusty Gage, who became the Institute’s President a year ago, expanding his tenure through 2024.
LA JOLLA—When we perceive the world around us, certain objects appear to be more noticeable than others, depending on what we do. For example, when we view a forest-covered mountain from a distance, the forest looks like a large green carpet. But as we get closer, we start noticing the individual trees, and the forest fades to the background. What happens in the brain as our experience changes so drastically?
LA JOLLA—Doctors have long observed that biological age and chronological age are not always one and the same. A 55-year-old may exhibit many signs of old age and have numerous age-related diseases, whereas an 80-year-old may be healthy and robust. While diet, physical activity and other factors play a role, there are many contributors as to why and how some people age better than others. Those contributors remain poorly understood.
LA JOLLA—Xin Jin, an associate professor in Salk’s Molecular Neurobiology Laboratory, has been selected as one of four scientists to receive the McKnight Memory and Cognitive Disorders award from the McKnight Endowment Fund for Neuroscience to study how the brain learns, remembers and executes actions. The award, which comprises $300,000 over three years, includes participation in the annual McKnight Conference on Neuroscience.
LA JOLLA—When a building is damaged, a general contractor often oversees various subcontractors—framers, electricians, plumbers and drywall hangers—to ensure repairs are done in the correct order and on time.
LA JOLLA—Associate Professor Janelle Ayres has been awarded $1.8 million over two years by the NOMIS Foundation to study health as an active process in which microbes—including the trillions of microorganisms that call the human body home—initiate interactions that promote the health of the host.
LA JOLLA—For the eighth consecutive time, the Salk Institute’s strong financial health and continuing commitment to accountability and transparency have earned it a coveted 4-star (out of 4 stars) rating from Charity Navigator, America’s largest independent charity and nonprofit evaluator.
LA JOLLA—Salk Professors Joanne Chory, Joseph Ecker and Rusty Gage have once again been named to the Highly Cited Researchers list by Clarivate Analytics (formerly Thomson Reuters). The list selects researchers for “exceptional research performance” demonstrated by the production of multiple highly cited papers that rank in the top 1 percent by citations for field and year. Additionally, among the 4,058 researchers named as Highly Cited, Ecker is one of 194 researchers appearing in two separate categories: “plant and animal science,” as well as “molecular biology and genetics.”
LA JOLLA—Nicola Allen, an assistant professor in Salk’s Molecular Neurobiology Laboratory, has received a five-year, $2.5 million Ben Barres Early Career Acceleration Award from the Chan Zuckerberg Initiative (CZI), as part of a $51.95 million effort launching the CZI Neurodegeneration Challenge Network. This new network brings together experimental scientists from diverse research fields—neuroscience, cell biology, biochemistry, immunology and genomics—along with computational biologists and physicians, to understand the underlying causes of disorders such as Alzheimer’s, Parkinson’s, Huntington’s disease and ALS.
LA JOLLA—Embryonic stem cells (ESCs) are the very definition of being full of potential, given that they can become any type of cell in the body. Once they start down any particular path toward a type of tissue, they lose their unlimited potential. Scientists have been trying to understand why and how this happens in order to create regenerative therapies that can, for example, coax a person’s own cells to replace damaged or diseased organs.
LA JOLLA—It might seem like fruit flies would have nothing in common with computers, but new research from the Salk Institute reveals that the two identify novel information in similar ways. The work, which appeared in Proceedings of the National Academy of Sciences (PNAS) on December 3, 2018, not only sheds light on an important neurobiological problem—how organisms detect new odors—but could also improve algorithms for novelty detection in computer science.
LA JOLLA—Salk Professor and Howard Hughes Medical Investigator Ronald Evans, who is also director of Salk’s Gene Expression Laboratory, has been a named a 2018 Fellow of the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society. In particular, the AAAS acknowledges his discoveries on steroid and orphan receptor signaling, revealing a “treasure trove” of both known and novel branches of physiology, metabolism and disease, according to the citation.
LA JOLLA—For most, the time spent staring at screens—on computers, phones, iPads—constitutes many hours and can often disrupt sleep. Now, Salk Institute researchers have pinpointed how certain cells in the eye process ambient light and reset our internal clocks, the daily cycles of physiological processes known as the circadian rhythm. When these cells are exposed to artificial light late into the night, our internal clocks can get confused, resulting in a host of health issues.
LA JOLLA—Old age is the greatest risk factor for many diseases, including Alzheimer’s disease (AD) and cancer. Geroprotectors are a recently identified class of anti-aging compounds. New Salk research has now identified a unique subclass of these compounds, dubbed geroneuroprotectors (GNPs), which are AD drug candidates and slow the aging process in mice.
LA JOLLA—A team of Salk Institute researchers led by President Rusty Gage has been awarded $19.2 million over eight years by the American Heart Association-Allen Initiative in Brain Health and Cognitive Impairment to investigate mechanisms underlying Alzheimer’s disease and aging-related cognitive decline and uncover new therapies. This bold venture will comprehensively analyze interactions between five areas key to brain health: proteins, genes, metabolism, inflammation and epigenetics.
LA JOLLA—Long thought to suppress cancer by slowing cellular metabolism, the protein complex AMPK also seemed to help some tumors grow, confounding researchers. Now, Salk Institute researchers have solved the long-standing mystery around why AMPK can both hinder and help cancer.
LA JOLLA—Clodagh O’Shea, a professor in Salk’s Molecular and Cell Biology Laboratory and a Howard Hughes Medical Institute Faculty Scholar, has been selected as a recipient of The Paul G. Allen Frontiers Group’s Allen Distinguished Investigator (ADI) program. She will be awarded $1.5 million over three years to conduct research into how DNA and its associated proteins (known collectively as chromatin) are packaged in the nucleus of cells. The work has implications for better understanding not only a range of diseases but also the fundamentals of human biology.