Juan Carlos Izpisua Belmonte

Professor

Gene Expression Laboratory

Roger Guillemin Chair

Salk Institute for Biological Studies - News – Belmonte

News – Belmonte


MicroRNA helps cancer evade immune system

LA JOLLA—The immune system automatically destroys dysfunctional cells such as cancer cells, but cancerous tumors often survive nonetheless. A new study by Salk scientists shows one method by which fast-growing …


Early gene-editing success holds promise for preventing inherited diseases

LA JOLLA—Scientists have, for the first time, corrected a disease-causing mutation in early stage human embryos with gene editing. The technique, which uses the CRISPR-Cas9 system, corrected the mutation for …


Novel tool confers targeted, stable editing of epigenome in human stem cells

LA JOLLA—Salk Institute scientists have developed a novel technology to correct disease-causing aberrations in the chemical tags on DNA that affect how genes are expressed. These types of chemical modifications, …


Identical twins; not-so-identical stem cells

LA JOLLA—Salk scientists and collaborators have shed light on a longstanding question about what leads to variation in stem cells by comparing induced pluripotent stem cells (iPSCs) derived from identical …


Salk scientists expand ability of stem cells to regrow any tissue type

LA JOLLA—When scientists talk about laboratory stem cells being totipotent or pluripotent, they mean that the cells have the potential, like an embryo, to develop into any type of tissue …


New findings highlight promise of chimeric organisms for science and medicine

LA JOLLA—Rapid advances in the ability to grow cells, tissues and organs of one species within an organism of a different species offer an unprecedented opportunity for tackling longstanding scientific …


Turning back time: Salk scientists reverse signs of aging

LA JOLLA—Graying hair, crow’s feet, an injury that’s taking longer to heal than when we were 20—faced with the unmistakable signs of aging, most of us have had a least …


New gene-editing technology partially restores vision in blind animals

LA JOLLA—Salk Institute researchers have discovered a holy grail of gene editing—the ability to, for the first time, insert DNA at a target location into the non-dividing cells that make …


Salk professor awarded multimillion dollar NIH Pioneer Award for innovations in cell biology

LA JOLLA—Salk Professor Juan Carlos Izpisua Belmonte has been awarded a 2016 National Institutes of Health Pioneer Award, a highly coveted grant that supports the most innovative biomedical research, for …


New method creates endless supply of kidney precursor cells

Salk researchers created kidney progenitor cells that survive in the lab using 3D culture and a mix of supporting molecules. The technology could help point to new cell therapies.

Click …


Stem cells move one step closer to cure for genetic diseases

LA JOLLA–Healthy brain, muscle, eye and heart cells would improve the lives of tens of thousands of people around the world with debilitating mitochondrial diseases. Now, researchers at the Salk …


New stem cell may overcome hurdles for regenerative medicine

LA JOLLA–Scientists at the Salk Institute have discovered a novel type of pluripotent stem cell–cells capable of developing into any type of tissue–whose identity is tied to their location in …


Scientists discover key driver of human aging

LA JOLLA–A study tying the aging process to the deterioration of tightly packaged bundles of cellular DNA could lead to methods of preventing and treating age-related diseases such as cancer, …


Gene-editing technique offers hope for hereditary diseases

LA JOLLA–For thousands of women around the globe carrying a mitochondrial disease, having a healthy child can be a gamble. This set of diseases affect mitochondria, tiny powerhouses that generate …


Cellular scissors chop up HIV virus

LA JOLLA–Imagine a single drug that could prevent human immunodeficiency virus (HIV) infection, treat patients who have already contracted HIV, and even remove all the dormant copies of the virus …


Salk scientists discover a key to mending broken hearts

LA JOLLA–Researchers at the Salk Institute have healed injured hearts of living mice by reactivating long dormant molecular machinery found in the animals’ cells, a finding that could help pave …


Simple method turns human skin cells into immune-fighting white blood cells

LA JOLLA—For the first time, scientists have turned human skin cells into transplantable white blood cells, soldiers of the immune system that fight infections and invaders. The work, done at …


No extra mutations in modified stem cells, study finds

LA JOLLA—The ability to switch out one gene for another in a line of living stem cells has only crossed from science fiction to reality within this decade. As with …


Salk scientists for the first time generate “mini-kidney” structures from human stem cells

LA JOLLA, CA—Diseases affecting the kidneys represent a major and unsolved health issue worldwide. The kidneys rarely recover function once they are damaged by disease, highlighting the urgent need for …


Salk scientists discover more versatile approach to creating stem cells

LA JOLLA, CA—Stem cells are key to the promise of regenerative medicine: the repair or replacement of injured tissues with custom grown substitutes. Essential to this process are induced pluripotent …


Salk scientists develop faster, safer method for producing stem cells

LA JOLLA, CA—A new method for generating stem cells from mature cells promises to boost stem cell production in the laboratory, helping to remove a barrier to regenerative medicine therapies …


Neurons derived from cord blood cells may represent new therapeutic option

LA JOLLA, CA—For more than 20 years, doctors have been using cells from blood that remains in the placenta and umbilical cord after childbirth to treat a variety of illnesses, …


Salk researchers develop safe way to repair sickle cell disease genes

LA JOLLA, CA—Researchers at the Salk Institute for Biological Studies have developed a way to use patients’ own cells to potentially cure sickle cell disease and many other disorders caused …


Editing scrambled genes in human stem cells may help realize the promise of combined stem cell-gene therapy

LA JOLLA, CA—In principle, genetic engineering is simple, but in practice, replacing a faulty gene with a healthy copy is anything but. Using mutated versions of the lamin A gene …


Aging, interrupted

LA JOLLA, CA—The current pace of population aging is without parallel in human history but surprisingly little is known about the human aging process, because lifespans of eight decades or …


Zebrafish study with human heart implications: Cellular grown-ups outperform stem cells in cardiac repair

LA JOLLA, CA—Bony fish like the tiny zebrafish have a remarkable ability that mammals can only dream of: if you lop off a chunk of their heart they swim sluggishly …


Unraveling the mechanisms behind organ regeneration in zebrafish

LA JOLLA, CA—The search for the holy grail of regenerative medicine—the ability to “grow back” a perfect body part when one is lost to injury or disease—has been under way …


Umbilical cord blood as a readily available source for off-the-shelf, patient-specific stem cells

LA JOLLA, CA—Umbilical cord blood cells can successfully be reprogrammed to function like embryonic stem cells, setting the basis for the creation of a comprehensive bank of tissue-matched, cord blood-derived …


Tumor suppressor pulls double shift as reprogramming watchdog

LA JOLLA, CA—A collaborative study by researchers at the Salk Institute for Biological Studies uncovered that the tumor suppressor p53, which made its name as “guardian of the genome,” not …


Genetic Re-disposition: Combined stem cell-gene therapy approach cures human genetic disease in vitro

La Jolla, CA—A study led by researchers at the Salk Institute for Biological Studies, has catapulted the field of regenerative medicine significantly forward, proving in principle that a human genetic …


Salk Receives $6.6 Million Grant to Develop Stem Cell-Based Treatments for Incurable Diseases

La Jolla, CA — The Salk Institute for Biological Studies has been awarded a $6.6 million grant – the largest single award in the latest competition — by …


Salk researchers successfully reprogram keratinocytes attached to a single hair

The first reports of the successful reprogramming of adult human cells back into so-called induced pluripotent stem (iPS) cells, which by all appearances looked and acted liked embryonic …


Starting over: Wnt reactivates dormant limb regeneration program

La Jolla, CA – Chop off a salamander’s leg and a brand new one will sprout in no time. But most animals have lost the ability to replace …


In early embryos, cilia get the message across

La Jolla, CA – Having your heart in the right place usually means having it located on the left side of your body. But just how a perfectly …


Finding a cellular Neverland: How stem cells stay childlike

La Jolla, CA – Despite their celebrated “immortality,” the capacity of embryonic stem (ES) cells for endless division has its limits. After a very extended childhood spent …


The ultimate spa: embryonic body wash controls left-right development

La Jolla, CA – Humans and other animals may appear to be symmetrical on the outside, but symmetry is only skin deep. Many body organs, such as the stomach, the …


Vitamin A’s paradoxical role in influencing symmetry during embryonic development revealed by Salk Institute scientists

La Jolla, CA – In this week’s journal Nature, scientists at the Salk Institute for Biological Studies report that they have solved one of the ‘holy grail’ puzzles of developmental …


Novel Genetic Pathway Tells Developing Body Organs to Get In Line

La Jolla, CA – Scientists at the Salk Institute have discovered a novel genetic pathway that ensures body organs develop correctly and in the right position during embryonic development. The …


Salk Study Uncovers New Information About Organ Placement

La Jolla, CA – A Salk Institute team of biologists, mathematicians, and physicists has uncovered a novel paradigm for cell communication that provides new insights into the complex question of …


Salk Scientists Find Genes That Control Limb Formation In Vertebrates

La Jolla, CA – Whether they’re wings, fins or legs, those appendages generally known as limbs play a critical role for lifting, grasping, moving and other activities needed to sustain …


Vitamin A Shown To Be Critical For Heart Location In Vertebrate Animals

La Jolla, CA – To make sure your heart’s in the right place, you need to add just the right amount of vitamin A.

According to new research led by scientists …


Gene Switches Wing To Leg, Salk Scientists Find

La Jolla, CA – A single gene can transform embryonic tissue destined to form a wing into a leg instead, Salk Institute investigators have found. Their studies were performed in …


Gene that determines left from right in vertebrate embryos found by Salk-led team

La Jolla, CA – In a developing organism, knowledge of right from left can often mean the difference between life and death. Certainly, the direction and ultimate destination in which …


Education

Bachelor's of Pharmacy and Science, University of Valencia
PhD, Universities of Bologna, Italy and Valencia, Spain
Postdoctoral Fellow, University of Marburg; The European Molecular Biology Laboratories at Heidelberg, Germany; University of California, Los Angeles