LA JOLLA—Long thought to suppress cancer by slowing cellular metabolism, the protein complex AMPK also seemed to help some tumors grow, confounding researchers. Now, Salk Institute researchers have solved the long-standing mystery around why AMPK can both hinder and help cancer. Read more »
Targeting fat to treat cancer
Fat isn’t just something we eat: it may also lie at the heart of a new approach to treating cancer.
Cells create their own fat molecules to build their plasma membranes and other critical structures. Now, researchers at the Salk Institute, along with academic and industry collaborators, have found a way to obstruct this instrumental process to stifle cancer’s growth, detailed September 19, 2016 in Nature Medicine. Like halting the delivery of supplies to a construction site, the approach stalls the molecular building blocks cancer needs to grow. Read more »
Salk scientists discover how mitochondria recover after damage
Salk scientists discover how mitochondria recover after damage, offering clues to cancer, diabetes and brain disease.
Mitochondria, the power generators in our cells, are essential for life. When they are under attack—from poisons, environmental stress or genetic mutations—cells wrench these power stations apart, strip out the damaged pieces and reassemble them into usable mitochondria. Read more »
Blocking Cellular “Recycling” Destroys Cancer
The Salk Institute and Sanford Burnham Prebys Medical Discovery Institute created a compound that stops a cellular recycling process. Read more »
Gene Discovery May Stop the Spread of Lung Cancer
A new study by Professor Reuben Shaw of the Salk Institute has found a new gene which may combat the spread of certain types of lung cancers. Read more »
Diabetes Drug Could Hold Promise for Lung Cancer Patients
Ever since discovering a decade ago that a gene altered in lung cancer regulated an enzyme used in therapies against diabetes, Reuben Shaw has wondered if drugs originally designed to treat metabolic diseases could also work against cancer. Read more »
“Fasting pathway” points the way to new class of diabetes drugs
HDAC inhibitors may provide a novel way to cut excessive blood glucose levels at the source.
A uniquely collaborative study by researchers at the Salk Institute for Biological Studies uncovered a novel mechanism that turns up glucose production in the liver when blood sugar levels drop, pointing towards a new class of drugs for the treatment of metabolic disease. Their findings, published in the May 13, 2011, issue of the journal Cell, revealed a crucial role for so called histone deacetylases (HDACs), a group of enzymes that is the target of the latest generation of cancer drugs. Read more »
How cells running on empty trigger fuel recycling
Researchers at the Salk Institute for Biological Studies have discovered how AMPK, a metabolic master switch that springs into gear when cells run low on energy, revs up a cellular recycling program to free up essential molecular building blocks in times of need. Read more »
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BS Biology, Cornell University, Ithaca, NY
PhD, Biology, Massachusetts Institute of Technology, Cambridge, MA
Postdoctoral Fellow, Harvard Medical School, Boston, MA
Awards & Honors
NCI Outstanding Investigator Award
Howard Hughes Medical Institute Early Career Scientist
American Cancer Society Research Scholar Award
American Diabetes Association Junior Faculty Award