Reuben Shaw

Professor

Molecular and Cell Biology Laboratory

William R. Brody Chair

Salk Institute for Biological Studies - Publications

Publications


Herzig, S. and Shaw, R.J. (2018) AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol 19:121-135. doi: 10.1038/nrm.2017.95. Review. PMCID: PMC5780224.

Bar-Peled, L., Kemper, E.K., Suciu, R.M., Vinogradova, E.V., Backus, K.M., Horning, B.D., Paul, T.A., Ichu, T.A., Svensson, R.U., Olucha, J., Chang, M.W., Kok, B.P., Zhu, Z., Ihle, N.T., Dix, M.M., Jiang, P., Hayward, M.M., Saez, E., Shaw, R.J., and Cravatt, B.F. (2017) Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell 171:696-709.e23. doi: 10.1016/j.cell.2017.08.051. PMCID: PMC5728659.

Garcia, D. and Shaw, R.J. (2017) AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance. Mol Cell 66:789-800. doi: 10.1016/j.molcel.2017.05.032. Review. PMCID: PMC5553560. https://www.ncbi.nlm.nih.gov/pubmed/28622524

Howell, J. J., Hellberg, K., Turner, M., Talbott, G., Kolar, M. J., Ross, D. S., Hoxhaj, G., Saghatelian, A., Shaw, R. J. and Manning, B. D. (2017) Metformin inhibits hepatic mtorc1 signaling via dose-dependent mechanisms involving ampk and the tsc complex. Cell Metab 25: 463-471.

Svensson, R.U. and Shaw, R.J. (2016) Lipid Synthesis Is a Metabolic Liability of Non-Small Cell Lung Cancer. Cold Spring Harb Symp Quant Biol 81:93-103. doi: 10.1101/sqb.2016.81.030874. Review. PubMed PMID: 28062532.

Parker, S. J., Svensson, R. U., Divakaruni, A. S., Lefebvre, A. E., Murphy, A. N., Shaw, R. J. and Metallo, C. M. (2016). Lkb1 promotes metabolic flexibility in response to energy stress. Metab Eng 43(Pt B):208-217. doi: 10.1016/j.ymben.2016.12.010. PMCID: PMC5484750.

Svensson, R.U., Parker, S.J., Eichner, L.J., Kolar, M.J., Wallace, M., Brun, S.N., Lombardo, P.S., Van Nostrand, J.L., Hutchins, A., Vera, L., Gerken, L., Greenwood, J., Bhat, S., Harriman, G., Westlin, W.F., Harwood Jr., H.J., Saghatelian, A., Kapeller, R., Metallo, C.M., and Shaw, R.J. (2016) Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small cell lung cancer in preclinical modelsNature Medicine, 22:1108-1119.

Young N.P., Kamireddy A., Van Nostrand J.L., Eichner L.J., Shokhirev M.N., Dayn Y., Shaw R.J. (2016) AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. Genes Dev. 2016 Mar 1;30(5):535-52.

Toyama, E.Q., Herzig, S., Courchet, J., Lewis, T.L. Jr., Losón, O.C., Hellberg, K., Young, N.P., Chen, H., Polleux, F., Chan, D.C., and Shaw, R.J. (2016) AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science 351: 275-281

Schaffer, B.E., Hertz, N.T., Levin, R.S., Maures, T.J., Schoof, M.L., Hollstein, P.E., Benayoun, B.A., Banko, M.R., Shaw, R.J., Shokat, K.M., Brunet, A. (2015) Identification of AMPK phosphorylation sites reveals a network of proteins involved in cell invasion and facilitates large-scale substrate predictionCell Metab 22 :907-21

Egan, D., Chun, M., Vamos, M., Zou, H., Rong, J., Miller, C., Lou, H., Raveendra-Panickar, D., Yang, C., Sheffler, D., Teriete, P., Asara, J., Turk, B., Cosford, N., and Shaw, R.J. (2015) Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 SubstratesMol Cell 59:285-297.

Goodwin, J.M., Svensson, R.U., Lou, H.J., Winslow, M.M., Turk, B.E., and Shaw, R.J. (2014). An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic PotentialMolecular Cell 55: 436–450.

Mochiroud, L., Eichner, L.J., Shaw, R.J. and Auwerx, J. (2014) Transcriptional Coregulators: Fine-Tuning MetabolismCell Metab 20:26-40.

Luan, B., Goodarzi, M.O., Phillips, N.G., Guo, X., Chen, Y.D., Yao, J., Allison, M., Rotter, J.I., Shaw, R., and Montminy, M. (2014) Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4Cell Metab 19:1058-1065.

Mihaylova, M.M. and Shaw, R.J. (2013) Metabolic reprogramming by class I and II histone deacetylases. Trends Endocrinol Metab 24:48-57.

Shackelford, D.B., Abt, E., Gerken, L., Vasquez, D.S., Atsuko, S., Leblanc, M., Wei, L., Fishbein, M.C., Czernin, J., Mischel, P.S. and Shaw, R.J. (2013) LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenforminCancer Cell 23:143-158.

Auricchio, N., Malinowska, I., Shaw, R., Manning, B.D., and Kwiatkowski, D.J. (2012). Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC)PLoS ONE 7:e31900.

Shaw, R.J. and Cantley, L.C. (2012) Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things niceF1000 Biol Rep 4:2.

Shaw, R.J. and Cantley, L.C. (2012) Ancient Sensor for Ancient DrugScience 336:813-4.

Svensson, R.U. and Shaw, R.J. (2012) Cancer metabolism: Tumour friend or foeNature 485:590-591.

Xia, Y., Yeddula, N., LeBlanc, M., Ke, E., Zhang, Y., Oldfield, E., Shaw, R.J. and Verma, I.M. (2012) Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer modelNat Cell Biol 14:257-65.

Akhtar, A., Fuchs, E., Mitchison, T., Shaw, R.J., St. Johnston, D., Strasser, A., Taylor, S., Walczak, C. and Zerial, M. (2011) A decade of molecular cell biology: achievements and challengesNat Rev Mol Cell Biol 12:669-674.

Mihaylova, M.M., Vasquez, D.S., Ravnskjaer, K., Denechaud, P-D., Yu, R.T., Alvarez, J.G., Downes, M., Evans, R.M., Montminy, M. and Shaw, R.J. (2011) Class IIa Histone Deacetylases are Hormone-activated regulators of FOXO and Mammalian Glucose HomeostasisCell 145, 1-15. [doi:10.1016/j.cell.2011.03.043]

Li, Y., Xu, S., Mihaylova, M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, E., Shyy, J.Y-J., Gao, B., Wierzbicki, M., Verbeuren, T.J., Shaw, R.J., Cohen, R.A. and Zang, M. (2011) AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-induced Insulin Resistant MiceCell Metab 13, 376-388.

Mair, W., Morantte, I., Rodrigues, A.P., Manning, G., Montminy, M., Shaw, R.J. and Dillin, A. (2011) Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREBNature 470, 404-408.

Egan, D.F., Shackelford, D.B., Mihaylova, M.M., Gelino, S.R., Kohnz, R.A., Mair, W., Vasquez, D.S., Joshi, A., Gwinn, D.M., Taylor, R., Asara, J.M., Fitzpatrick, J., Dillin, A., Viollet, B., Kundu. M., Hansen, M. and Shaw, R.J. (2011) Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to MitophagyScience 331, 456-461.

Shackelford, D.B. and Shaw, R.J. (2009) The LKB1-AMPK pathway: metabolism and growth control in tumor suppression. Nat. Rev. Cancer, 9, 563-575.

Shackelford, D.B., Vasquez, D.S., Corbeil, J., Wu, S., Leblanc, M., Wu, C.L., Vera, D.R., and Shaw, R.J. (2009) mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndromePNAS 106, 11137-11142.

Narkar, V.A., Downes, M., Yu, R.T., Wang, Y.X., Kanakubo, E., Banayo, E., Mihaylova, M.M., Nelson, M.C., Zou, Y., Juguilon, H., Kang. H., Shaw, R.J., and Evans. R.M. (2008) AMPK and PPARβ/δ agonists are exercise mimeticsCell 134, 405-415.

Gwinn, D.M., Shackelford, D.B., Egan., D.F., Mihaylova, M.M., Mery, A., Vasquez, D.S., Turk, B.E., and Shaw, R.J. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpointMol Cell 30, 214-26.

Shaw, R.J. Glucose metabolism and cancer. (2006) Curr. Opin. Cell Biol. 18, 598-608.

Shaw, R.J. and Cantley, L.C. (2006) Ras, PI(3)K, and mTOR signaling controls tumor cell growthNature 441, 424-430.

Shaw, R.J., Lamia, K.A., Vasquez, D., Koo, S.H., Bardeesy, N., DePinho, R.A., Montminy, M., Cantley, L.C. (2005) The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of MetforminScience 310, 1642-6.

Shaw, R.J., Bardeesy, N., Manning, B., Lopez, L. Kosmatka, M., DePinho, R.A., and Cantley, L.C. (2004). The LKB1 tumor suppressor negatively regulates mTOR signalingCancer Cell 6, 91-99

Shaw, R.J., Kosmatka, M., Bardeesy, N., Hurley, R.L., Witters, L.A., DePinho, R.A., Cantley, L.C. (2004). The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressPNAS 101, 3329-3335

Education

BS Biology, Cornell University, Ithaca, NY
PhD, Biology, Massachusetts Institute of Technology, Cambridge, MA
Postdoctoral Fellow, Harvard Medical School, Boston, MA


Awards & Honors

  • NCI Outstanding Investigator Award
  • Howard Hughes Medical Institute Early Career Scientist
  • American Cancer Society Research Scholar Award
  • American Diabetes Association Junior Faculty Award