Reuben Shaw

Professor

Molecular and Cell Biology Laboratory

William R. Brody Chair

Salk Institute for Biological Studies - Publications

all Publications


Stein, B.D., Herzig, S., Martínez-Bartolomé, S., Lavallée-Adam, M., Shaw, R.J., Yates, J.R. Comparison of CRISPR Genomic Tagging for Affinity Purification and Endogenous Immunoprecipitation Coupled with Quantitative Mass Spectrometry To Identify the Dynamic AMPKα2 Interactome. (2019) Journal of Proteome Research. DOI: 10.1021/acs.jproteome.9b00378

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Hollstein, P.E., Eichner, L.J., Brun, S.N., Kamireddy, A., Svensson, R.U., Vera, L.I., Ross, D.S., Rymoff, T.J., Hutchins, A., Galvez, H.M., Williams, A.E., Shokhirev, M.N., Screaton, R.A., Berdeaux, R., Shaw, R.J. The AMPK-related kinases SIK1 and SIK3 mediate key tumor suppressive effects of LKB1 in NSCLC. (2019) Cancer Discovery. DOI: 10.1158/2159-8290.CD-18-1261

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Rodón, L., Svensson, R.U., Wiater, E., Chun, M.G.H., Tsai, W.W., Eichner, L.J., Shaw, R.J., Montminy, M. The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer. (2019) Science Advances. 5(7):eaaw6455. DOI: 10.1126/sciadv.aaw6455

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Hishida, T., Vazquez-Ferrer, E., Hishida-Nozaki, Y., Sancho-Martinez, I., Takahashi, Y., Hatanaka, F., Wu, J., Ocampo, A., Reddy, P., Wu, M.Z., Gerken, L., Shaw, R.J., Rodriguez Esteban, C., Benner, C., Nakagawa, H., Guillen Garcia, P., Nuñez Delicado, E., Castells, A., Campistol, J.M., Liu, G.H., Izpisua Belmonte, J.C. Mutations in foregut SOX2 cells induce efficient proliferation via CXCR2 pathway. (2019) Protein & Cell. 10(7):485-495. DOI: 10.1007/s13238-019-0630-3

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Garcia, D., Hellberg, K., Chaix, A., Wallace, M., Herzig, S., Badur, M.G., Lin, T., Shokhirev, M.N., Pinto, A.F.M., Ross, D.S., Saghatelian, A., Panda, S., Dow, L.E., Metallo, C.M., Shaw, R.J. Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD. (2019) Cell Reports. 26(1):192-208.e6. DOI: 10.1016/j.celrep.2018.12.036

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Nassour, J., Radford, R., Correia, A., Fusté, J.M., Schoell, B., Jauch, A., Shaw, R.J., Karlseder, J. Autophagic cell death restricts chromosomal instability during replicative crisis. (2019) Nature. 565(7741):659-663. DOI: 10.1038/s41586-019-0885-0

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Limpert, A.S., Lambert, L.J., Bakas, N.A., Bata, N., Brun, S.N., Shaw, R.J., Cosford, N.D.P. Autophagy in Cancer: Regulation by Small Molecules. (2018) Trends in Pharmacological Sciences. 39(12):1021-1032. DOI: 10.1016/j.tips.2018.10.004

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Eichner, L.J., Brun, S.N., Herzig, S., Young, N.P., Curtis, S.D., Shackelford, D.B., Shokhirev, M.N., Leblanc, M., Vera, L.I., Hutchins, A., Ross, D.S., Shaw, R.J., Svensson, R.U. Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models. (2018) Cell Metabolism. 29(2):285-302. DOI: 10.1016/j.cmet.2018.10.005

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Lewis, T.L., Kwon, S.K., Lee, A., Shaw, R., Polleux, F. MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size. (2018) Nature Communications. 9(1):5008. DOI: 10.1038/s41467-018-07416-2

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Fiedler, E.C., Shaw, R.J. AMPK Regulates the Epigenome through Phosphorylation of TET2. (2018) Cell Metabolism. 28(4):534-536. DOI: 10.1016/j.cmet.2018.09.015

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Hollstein, P.E., Shaw, R.J. Inflamed T cells and stroma drive gut tumors. (2018) Science. 361(6400):332-333. DOI: 10.1126/science.aau4804


Hollstein, P.E., Shaw, R.J. GNAS shifts metabolism in pancreatic cancer. (2018) Nature Cell Biology. 20(7):740-741. DOI: 10.1038/s41556-018-0120-5


Herzig, S., Shaw, R.J. AMPK: guardian of metabolism and mitochondrial homeostasis. (2017) Nature Reviews. Molecular Cell Biology. 19(2):121-135. DOI: 10.1038/nrm.2017.95

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Bar-Peled, L., Kemper, E.K., Suciu, R.M., Vinogradova, E.V., Backus, K.M., Horning, B.D., Paul, T.A., Ichu, T.A., Svensson, R.U., Olucha, J., Chang, M.W., Kok, B.P., Zhu, Z., Ihle, N.T., Dix, M.M., Jiang, P., Hayward, M.M., Saez, E., Shaw, R.J., Cravatt, B.F. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. (2017) Cell. 171(3):696-709. DOI: 10.1016/j.cell.2017.08.051

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Garcia, D., Shaw, R.J. AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance. (2017) Molecular Cell. 66(6):789-800. DOI: 10.1016/j.molcel.2017.05.032

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Ruggero, D., Shaw, R.J. Editorial overview: Cell regulation: 1000 Flavors including chocolate and chili peppers. (2017) Current Opinion in Cell Biology. 45:iv-vi. DOI: 10.1016/j.ceb.2017.05.008


Howell, J.J., Hellberg, K., Turner, M., Talbott, G., Kolar, M.J., Ross, D.S., Hoxhaj, G., Saghatelian, A., Shaw, R.J., Manning, B.D. Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex. (2017) Cell Metabolism. 25(2):463-471. DOI: 10.1016/j.cmet.2016.12.009

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Svensson, R.U., Shaw, R.J. Lipid Synthesis Is a Metabolic Liability of Non-Small Cell Lung Cancer. (2016) Cold Spring Harbor Symposia on Quantitative Biology. 81:93-103. DOI: 10.1101/sqb.2016.81.030874

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Parker, S.J., Svensson, R.U., Divakaruni, A.S., Lefebvre, A.E., Murphy, A.N., Shaw, R.J., Metallo, C.M. LKB1 promotes metabolic flexibility in response to energy stress. (2016) Metabolic Engineering.(43(Pt B)):208-217 DOI: 10.1016/j.ymben.2016.12.010

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Svensson, R.U., Parker, S.J., Eichner, L.J., Kolar, M.J., Wallace, M., Brun, S.N., Lombardo, P.S., Van Nostrand, J.L., Hutchins, A., Vera, L., Gerken, L., Greenwood, J., Bhat, S., Harriman, G., Westlin, W.F., Harwood, H.J., Saghatelian, A., Kapeller, R., Metallo, C.M., Shaw, R.J. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. (2016) Nature Medicine. 22(10):1108-1119. DOI: 10.1038/nm.4181

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Merkwirth, C., Jovaisaite, V., Durieux, J., Matilainen, O., Jordan, S.D., Quiros, P.M., Steffen, K.K., Williams, E.G., Mouchiroud, L., Tronnes, S.U., Murillo, V., Wolff, S.C., Shaw, R.J., Auwerx, J., Dillin, A. Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity. (2016) Cell. 165(5):1209-23. DOI: 10.1016/j.cell.2016.04.012

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Young, N.P., Kamireddy, A., Van Nostrand, J.L., Eichner, L.J., Shokhirev, M.N., Dayn, Y., Shaw, R.J. AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. (2016) Genes & Development. 30(5):535-52. DOI: 10.1101/gad.274142.115

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Toyama, E.Q., Herzig, S., Courchet, J., Lewis, T.L., Losón, O.C., Hellberg, K., Young, N.P., Chen, H., Polleux, F., Chan, D.C., Shaw, R.J. Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. (2016) Science. 351(6270):275-281. DOI: 10.1126/science.aab4138

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Shaw, R.J. AMPK Keeps Tumor Cells from Starving to Death. (2015) Cell Stem Cell. 17(5):503-4. DOI: 10.1016/j.stem.2015.10.007

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Schaffer, B.E., Levin, R.S., Hertz, N.T., Maures, T.J., Schoof, M.L., Hollstein, P.E., Benayoun, B.A., Banko, M.R., Shaw, R.J., Shokat, K.M., Brunet, A. Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction. (2015) Cell Metabolism. 22(5):907-21. DOI: 10.1016/j.cmet.2015.09.009

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McClatchy, D.B., Ma, Y., Liu, C., Stein, B.D., Martínez-Bartolomé, S., Vasquez, D., Hellberg, K., Shaw, R.J., Yates, J.R. Pulsed Azidohomoalanine Labeling in Mammals (PALM) Detects Changes in Liver-Specific LKB1 Knockout Mice. (2015) Journal of Proteome Research. 14(11):4815-22. DOI: 10.1021/acs.jproteome.5b00653

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Egan, D.F., Chun, M.G., Vamos, M., Zou, H., Rong, J., Miller, C.J., Lou, H.J., Raveendra-Panickar, D., Yang, C.C., Sheffler, D.J., Teriete, P., Asara, J.M., Turk, B.E., Cosford, N.D., Shaw, R.J. Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates. (2015) Molecular Cell. 59(2):285-97. DOI: 10.1016/j.molcel.2015.05.031

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Shaw, R.J. Tumor Metabolism: MAGE-A Proteins Help TRIM Turn Over AMPK. (2015) Current Biology. 25(10):R418-20. DOI: 10.1016/j.cub.2015.03.019

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Xia, Y., Yeddula, N., Leblanc, M., Ke, E., Zhang, Y., Oldfield, E., Shaw, R.J., Verma, I.M. Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model. (2015) Nature Cell Biology. 17(4):532. DOI: 10.1038/ncb3145


Goodwin, J.M., Svensson, R.U., Lou, H.J., Winslow, M.M., Turk, B.E., Shaw, R.J. An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential. (2014) Molecular Cell. 55(3):436-50. DOI: 10.1016/j.molcel.2014.06.021

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Mouchiroud, L., Eichner, L.J., Shaw, R.J., Auwerx, J. Transcriptional coregulators: fine-tuning metabolism. (2014) Cell Metabolism. 20(1):26-40. DOI: 10.1016/j.cmet.2014.03.027

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Luan, B., Goodarzi, M.O., Phillips, N.G., Guo, X., Chen, Y.D., Yao, J., Allison, M., Rotter, J.I., Shaw, R., Montminy, M. Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. (2014) Cell Metabolism. 19(6):1058-65. DOI: 10.1016/j.cmet.2014.03.024

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Faubert, B., Vincent, E.E., Griss, T., Samborska, B., Izreig, S., Svensson, R.U., Mamer, O.A., Avizonis, D., Shackelford, D.B., Shaw, R.J., Jones, R.G. Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(7):2554-9. DOI: 10.1073/pnas.1312570111

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Shaw, R.J. Metformin trims fats to restore insulin sensitivity. (2013) Nature Medicine. 19(12):1570-2. DOI: 10.1038/nm.3414


Masui, K., Tanaka, K., Akhavan, D., Babic, I., Gini, B., Matsutani, T., Iwanami, A., Liu, F., Villa, G.R., Gu, Y., Campos, C., Zhu, S., Yang, H., Yong, W.H., Cloughesy, T.F., Mellinghoff, I.K., Cavenee, W.K., Shaw, R.J., Mischel, P.S. mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. (2013) Cell Metabolism. 18(5):726-39. DOI: 10.1016/j.cmet.2013.09.013

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Liu, Y., Marks, K., Cowley, G.S., Carretero, J., Liu, Q., Nieland, T.J., Xu, C., Cohoon, T.J., Gao, P., Zhang, Y., Chen, Z., Altabef, A.B., Tchaicha, J.H., Wang, X., Choe, S., Driggers, E.M., Zhang, J., Bailey, S.T., Sharpless, N.E., Hayes, D.N., Patel, N.M., Janne, P.A., Bardeesy, N., Engelman, J.A., Manning, B.D., Shaw, R.J., Asara, J.M., Scully, R., Kimmelman, A., Byers, L.A., Gibbons, D.L., Wistuba, I.I., Heymach, J.V., Kwiatkowski, D.J., Kim, W.Y., Kung, A.L., Gray, N.S., Root, D.E., Cantley, L.C., Wong, K.K. Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. (2013) Cancer Discov. 3(8):870-9. DOI: 10.1158/2159-8290.CD-13-0015

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Chun, M.G., Shaw, R.J. Cancer metabolism in breadth and depth. (2013) Nature Biotechnology. 31(6):505-7. DOI: 10.1038/nbt.2611


Shaw, R.J. Cell biology. GATORs take a bite out of mTOR. (2013) Science. 340(6136):1056-7. DOI: 10.1126/science.1240315


Shackelford, D.B., Abt, E., Gerken, L., Vasquez, D.S., Seki, A., Leblanc, M., Wei, L., Fishbein, M.C., Czernin, J., Mischel, P.S., Shaw, R.J. LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. (2013) Cancer Cell. 23(2):143-58. DOI: 10.1016/j.ccr.2012.12.008

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Mihaylova, M.M., Shaw, R.J. Metabolic reprogramming by class I and II histone deacetylases. (2013) Trends in Endocrinology and Metabolism. 24(1):48-57. DOI: 10.1016/j.tem.2012.09.003

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Shaw, R.J., Cantley, L.C. Cell biology. Ancient sensor for ancient drug. (2012) Science. 336(6083):813-4. DOI: 10.1126/science.1223140


Svensson, R.U., Shaw, R.J. Cancer metabolism: Tumour friend or foe. (2012) Nature. 485(7400):590-1. DOI: 10.1038/485590a


Xia, Y., Yeddula, N., Leblanc, M., Ke, E., Zhang, Y., Oldfield, E., Shaw, R.J., Verma, I.M. Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model. (2012) Nature Cell Biology. 14(3):257-65. DOI: 10.1038/ncb2428

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Auricchio, N., Malinowska, I., Shaw, R., Manning, B.D., Kwiatkowski, D.J. Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC). (2012) PLOS One. 7(2):e31900. DOI: 10.1371/journal.pone.0031900

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Shaw, R.J., Cantley, L.C. Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice. (2012) F1000 Biology Reports. 4:2. DOI: 10.3410/B4-2

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Mihaylova, M.M., Shaw, R.J. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. (2011) Nature Cell Biology. 13(9):1016-23. DOI: 10.1038/ncb2329

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Akhtar, A., Fuchs, E., Mitchison, T., Shaw, R.J., St Johnston, D., Strasser, A., Taylor, S., Walczak, C., Zerial, M. A decade of molecular cell biology: achievements and challenges. (2011) Nature Reviews. Molecular Cell Biology. 12(10):669-74. DOI: 10.1038/nrm3187

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Egan, D., Kim, J., Shaw, R.J., Guan, K.L. The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR. (2011) Autophagy. 7(6):643-4.

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Mihaylova, M.M., Vasquez, D.S., Ravnskjaer, K., Denechaud, P.D., Yu, R.T., Alvarez, J.G., Downes, M., Evans, R.M., Montminy, M., Shaw, R.J. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. (2011) Cell. 145(4):607-21. DOI: 10.1016/j.cell.2011.03.043

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Wang, B., Moya, N., Niessen, S., Hoover, H., Mihaylova, M.M., Shaw, R.J., Yates, J.R., Fischer, W.H., Thomas, J.B., Montminy, M. A hormone-dependent module regulating energy balance. (2011) Cell. 145(4):596-606. DOI: 10.1016/j.cell.2011.04.013

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Li, Y., Xu, S., Mihaylova, M.M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, E., Shyy, J.Y., Gao, B., Wierzbicki, M., Verbeuren, T.J., Shaw, R.J., Cohen, R.A., Zang, M. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. (2011) Cell Metabolism. 13(4):376-388. DOI: 10.1016/j.cmet.2011.03.009

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Mair, W., Morantte, I., Rodrigues, A.P., Manning, G., Montminy, M., Shaw, R.J., Dillin, A. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. (2011) Nature. 470(7334):404-8. DOI: 10.1038/nature09706

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Birnbaum, M.J., Shaw, R.J. Genomics: Drugs, diabetes and cancer. (2011) Nature. 470(7334):338-9. DOI: 10.1038/470338a


Egan, D.F., Shackelford, D.B., Mihaylova, M.M., Gelino, S., Kohnz, R.A., Mair, W., Vasquez, D.S., Joshi, A., Gwinn, D.M., Taylor, R., Asara, J.M., Fitzpatrick, J., Dillin, A., Viollet, B., Kundu, M., Hansen, M., Shaw, R.J. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. (2011) Science. 331(6016):456-61. DOI: 10.1126/science.1196371

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Ohashi, K., Ouchi, N., Higuchi, A., Shaw, R.J., Walsh, K. LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis. (2010) Journal of Biological Chemistry. 285(29):22291-8. DOI: 10.1074/jbc.M110.123794

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Shaw, R.J., Evans, R.M., Simon, M.C. Metabolism and cancer in La Jolla. (2010) Cancer Research. 70(10):3864-9. DOI: 10.1158/0008-5472.CAN-09-4529


Shaw, R.J. Metabolism and cancer mix in Madrid. (2010) EMBO Reports. 11(4):249-51. DOI: 10.1038/embor.2010.40

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Gwinn, D.M., Asara, J.M., Shaw, R.J. Raptor is phosphorylated by cdc2 during mitosis. (2010) PLOS One. 5(2):e9197. DOI: 10.1371/journal.pone.0009197

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Shaw, R. Journal club. A cancer researcher ponders a fundamental connection between nutrients and gene expression. (2009) Nature. 462(7275):829. DOI: 10.1038/462829f


Ikeda, Y., Sato, K., Pimentel, D.R., Sam, F., Shaw, R.J., Dyck, J.R., Walsh, K. Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction. (2009) Journal of Biological Chemistry. 284(51):35839-49. DOI: 10.1074/jbc.M109.057273

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Lamia, K.A., Sachdeva, U.M., DiTacchio, L., Williams, E.C., Alvarez, J.G., Egan, D.F., Vasquez, D.S., Juguilon, H., Panda, S., Shaw, R.J., Thompson, C.B., Evans, R.M. AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. (2009) Science. 326(5951):437-40. DOI: 10.1126/science.1172156

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Shaw, R.J. Tumor suppression by LKB1: SIK-ness prevents metastasis. (2009) Science Signaling. 2(86):pe55. DOI: 10.1126/scisignal.286pe55

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Shackelford, D.B., Shaw, R.J. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. (2009) Nature Reviews. Cancer. 9(8):563-75. DOI: 10.1038/nrc2676

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Shackelford, D.B., Vasquez, D.S., Corbeil, J., Wu, S., Leblanc, M., Wu, C.L., Vera, D.R., Shaw, R.J. mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. (2009) Proceedings of the National Academy of Sciences of the United States of America. 106(27):11137-42. DOI: 10.1073/pnas.0900465106

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Shaw, R.J. LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. (2009) Acta Physiologica. 196(1):65-80. DOI: 10.1111/j.1748-1716.2009.01972.x

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Shaw, R., Dillin, A. PPTR-1 counterAkts insulin signaling. (2009) Cell. 136(5):816-8. DOI: 10.1016/j.cell.2009.02.029

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Mair, W., Panowski, S.H., Shaw, R.J., Dillin, A. Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. (2009) PLOS One. 4(2):e4535. DOI: 10.1371/journal.pone.0004535

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Shaw, R.J. mTOR signaling: RAG GTPases transmit the amino acid signal. (2008) Trends in Biochemical Sciences. 33(12):565-8. DOI: 10.1016/j.tibs.2008.09.005

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Shaw, R.J. Raptor swoops in on metabolism. (2008) Cell Metabolism. 8(5):343-4. DOI: 10.1016/j.cmet.2008.10.007

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Shaw, R.J. LKB1: cancer, polarity, metabolism, and now fertility. (2008) Biochemical Journal. 416(1):e1-3. DOI: 10.1042/BJ20082023

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Narkar, V.A., Downes, M., Yu, R.T., Embler, E., Wang, Y.X., Banayo, E., Mihaylova, M.M., Nelson, M.C., Zou, Y., Juguilon, H., Kang, H., Shaw, R.J., Evans, R.M. AMPK and PPARdelta agonists are exercise mimetics. (2008) Cell. 134(3):405-15. DOI: 10.1016/j.cell.2008.06.051

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Gwinn, D.M., Shackelford, D.B., Egan, D.F., Mihaylova, M.M., Mery, A., Vasquez, D.S., Turk, B.E., Shaw, R.J. AMPK phosphorylation of raptor mediates a metabolic checkpoint. (2008) Molecular Cell. 30(2):214-26. DOI: 10.1016/j.molcel.2008.03.003

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Shaw, R.J. Glucose metabolism and cancer. (2006) Current Opinion in Cell Biology. 18(6):598-608. DOI: 10.1016/j.ceb.2006.10.005

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Baur, J.A., Pearson, K.J., Price, N.L., Jamieson, H.A., Lerin, C., Kalra, A., Prabhu, V.V., Allard, J.S., Lopez-Lluch, G., Lewis, K., Pistell, P.J., Poosala, S., Becker, K.G., Boss, O., Gwinn, D., Wang, M., Ramaswamy, S., Fishbein, K.W., Spencer, R.G., Lakatta, E.G., Le Couteur, D., Shaw, R.J., Navas, P., Puigserver, P., Ingram, D.K., de Cabo, R., Sinclair, D.A. Resveratrol improves health and survival of mice on a high-calorie diet. (2006) Nature. 444(7117):337-42. DOI: 10.1038/nature05354

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Shaw, R.J., Cantley, L.C. Ras, PI(3)K and mTOR signalling controls tumour cell growth. (2006) Nature. 441(7092):424-30. DOI: 10.1038/nature04869

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Shaw, R.J., Lamia, K.A., Vasquez, D., Koo, S.H., Bardeesy, N., Depinho, R.A., Montminy, M., Cantley, L.C. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. (2005) Science. 310(5754):1642-6. DOI: 10.1126/science.1120781

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Fernandes, N., Sun, Y., Chen, S., Paul, P., Shaw, R.J., Cantley, L.C., Price, B.D. DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM. (2005) Journal of Biological Chemistry. 280(15):15158-64. DOI: 10.1074/jbc.M412065200

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Shaw, R.J., Bardeesy, N., Manning, B.D., Lopez, L., Kosmatka, M., DePinho, R.A., Cantley, L.C. The LKB1 tumor suppressor negatively regulates mTOR signaling. (2004) Cancer Cell. 6(1):91-9. DOI: 10.1016/j.ccr.2004.06.007

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Shaw, R.J., Kosmatka, M., Bardeesy, N., Hurley, R.L., Witters, L.A., DePinho, R.A., Cantley, L.C. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. (2004) Proceedings of the National Academy of Sciences of the United States of America. 101(10):3329-35. DOI: 10.1073/pnas.0308061100

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Shaw, R.J., Paez, J.G., Curto, M., Yaktine, A., Pruitt, W.M., Saotome, I., O'Bryan, J.P., Gupta, V., Ratner, N., Der, C.J., Jacks, T., McClatchey, A.I. The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. (2001) Developmental Cell. 1(1):63-72.

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Karuman, P., Gozani, O., Odze, R.D., Zhou, X.C., Zhu, H., Shaw, R., Brien, T.P., Bozzuto, C.D., Ooi, D., Cantley, L.C., Yuan, J. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. (2001) Molecular Cell. 7(6):1307-19.

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Shaw, R.J., McClatchey, A.I., Jacks, T. Localization and functional domains of the neurofibromatosis type II tumor suppressor, merlin. (1998) Cell Growth & Differentiation. 9(4):287-96.

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Shaw, R.J., McClatchey, A.I., Jacks, T. Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli. (1998) Journal of Biological Chemistry. 273(13):7757-64.

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Shaw, R.J., Henry, M., Solomon, F., Jacks, T. RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts. (1998) Molecular Biology of the Cell. 9(2):403-19.

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Platko, J.V., Leonard, D.A., Adra, C.N., Shaw, R.J., Cerione, R.A., Lim, B. A single residue can modify target-binding affinity and activity of the functional domain of the Rho-subfamily GDP dissociation inhibitors. (1995) Proceedings of the National Academy of Sciences of the United States of America. 92(7):2974-8.

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Education

BS Biology, Cornell University, Ithaca, NY
PhD, Biology, Massachusetts Institute of Technology, Cambridge, MA
Postdoctoral Fellow, Harvard Medical School, Boston, MA


Awards & Honors

  • NCI Outstanding Investigator Award
  • Howard Hughes Medical Institute Early Career Scientist
  • American Cancer Society Research Scholar Award
  • American Diabetes Association Junior Faculty Award