LA JOLLA—The Salk Institute Board of Trustees welcomes its newest trustee, Eric S. Sagerman. Chaired by Irwin M. Jacobs, the 33-member Salk board helps drives the strategic direction of the Institute founded by polio vaccine pioneer Jonas Salk in 1960.
LA JOLLA—Our brains contain a surprising diversity of DNA. Even though we are taught that every cell in our body has the same DNA, in fact most cells in the brain have changes to their DNA that make each neuron a little different.
LA JOLLA—The Johns Hopkins University School of Medicine and the Salk Institute for Biological Studies will co-lead a $15.4 million effort to develop new systems for quickly screening libraries of drugs for potential effectiveness against schizophrenia and bipolar disorder, the National Institute of Mental Health (NIMH) has announced. The consortium, which includes four academic or nonprofit institutions and two industry partners, will be led by Hongjun Song, PhD, of Johns Hopkins and Rusty Gage, PhD, of Salk.
LA JOLLA—Boosting levels of a specific protein in the brain alleviates hallmark features of Alzheimer’s disease in a mouse model of the disorder, according to new research published online August 25, 2016 in Scientific Reports.
LA JOLLA—Salk Institute scientists have discovered the holy grail of endless youthfulness—at least when it comes to one type of human kidney precursor cell. Previous attempts to maintain cultures of the so-called nephron progenitor cells often failed, as the cells died or gradually lost their developmental potential rather than staying in a more medically useful precursor state.
LA JOLLA—When you reach for that pan of brownies, a ball-shaped brain structure called the striatum is critical for controlling your movement toward the reward. A healthy striatum also helps you stop yourself when you’ve had enough.
LA JOLLA—For decades, scientists have known that people with two copies of a gene called apolipoprotein E4 (ApoE4) are much more likely to have Alzheimer’s disease at age 65 than the rest of the population. Now, researchers at the Salk Institute have identified a new connection between ApoE4 and protein build-up associated with Alzheimer’s that provides a possible biochemical explanation for how extra ApoE4 causes the disease.
LA JOLLA—The best natural chemists out there are not scientists—they’re plants. Plants have continued to evolve a rich palette of small natural chemicals and receptors since they began to inhabit land roughly 450 million years ago.
LA JOLLA—In a study spanning molecular genetics, stem cells and the sciences of both brain and behavior, researchers at University of California, San Diego and the Salk Institute have created a neurodevelopmental model of a rare genetic disorder that may provide new insights into the underlying neurobiology of the human social brain.
LA JOLLA—Visual prosthetics, or bionic eyes, are soon becoming a reality, as researchers make strides in strategies to reactivate parts of the brain that process visual information in people affected by blindness.
LA JOLLA—Salk Institute ranks as one of the leading scientific “stars” in North America with high-quality output that has grown particularly fast, according to a new report by Nature Research.
Helmsley-Salk Fellow Dmitry Lyumkis has been awarded the 2016 George Palade Award by the Microscopy Society of America. The award is given for distinguished contributions to the field of microscopy and microanalysis in the life sciences of an early career scientist.
LA JOLLA—Salk scientists and colleagues have proposed new molecular criteria for judging just how close any line of laboratory-generated stem cells comes to mimicking embryonic cells seen in the very earliest stages of human development, known as naïve stem cells. The tests found that no current protocols lead to truly naïve stem cells, but the guidelines may help researchers achieve that goal by pointing out where each current method falls short. Generating naïve stem cells would be a boon to both basic research and to medical applications of stem cells, such as growing tissue for organ replacement.
LA JOLLA—Our brains can survive only for a few minutes without oxygen. Salk Institute researchers have now identified the timing of a dramatic metabolic shift in developing neurons, which makes them become dependent on oxygen as a source of energy.
LA JOLLA—The brains of some people with autism spectrum disorder grow faster than usual early on in life, often before diagnosis. A new study co-led by Salk Institute scientists has employed a cutting-edge stem cell technique to unravel the mechanisms driving the mysterious phenomenon of excess brain growth, which affects as many as 30 percent of people with autism.
LA JOLLA—A small stretch of ribonucleic acid called microRNA could make the difference between a healthy adult brain and one that’s prone to disorders including schizophrenia.
LA JOLLA—The Salk Institute will celebrate 21 years of Symphony at Salk, its signature concert under the stars, with Broadway luminary Kelli O’Hara and the incomparable San Diego Symphony led by guest conductor Maestro Thomas Wilkins on Saturday, August 20.
LA JOLLA–Salk Institute scientists have found preliminary evidence that tetrahydrocannabinol (THC) and other compounds found in marijuana can promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer’s disease.
LA JOLLA—When the body is fighting an invading pathogen, white blood cells—including T cells—must respond. Now, Salk Institute researchers have imaged how vital receptors on the surface of T cells bundle together when activated.
LA JOLLA—The Salk Institute is pleased to announce the appointment of Sung Han as an assistant professor in the Clayton Foundation Peptide Biology Laboratories. Han will study small molecules, called neuropeptides, which affect the brain’s defense response and contribute to sensory hypersensitivity in neuropsychiatric disorders such as anxiety and autism.
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