Janelle Ayres, PhD

Professor

Salk Institute Legacy Chair

Areas of interest: inflammation and pathobionts in the gut microbiota

Disease models: pathobionts, colorectal cancer

Jesse Dixon, MD, PhD

Assistant Professor

Areas of interest: 3d genomic control

Disease models: pediatric leukemia, colon cancer

Joseph Ecker, PhD

Professor

Salk International Council Chair in Genetics

Areas of interest: epigenomics of stem cells and cancer cells

Disease models: breast cancer

Dannielle Engle, PhD

Assistant Professor

Regulatory Biology Laboratory

Helen McLoraine Developmental Chair in Neurobiology

Areas of interest: organoid technology, glycosylation in cancer, early detection/treatment, mouse models

Disease models: pancreatic cancer, pancreatitis

Ronald Evans, PhD

Professor and Director

March of Dimes Chair in Molecular and Developmental Biology

Areas of interest: nuclear receptor function in metabolism and cancer

Disease models: pancreatic cancer, colon cancer, diabetes

Rusty Gage, PhD

Professor

Laboratory of Genetics

Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease

Areas of interest: neurogenesis, adult stem cells, iPSCs

Disease models: human aging and age-associated diseases

Diana Hargreaves, PhD

Associate Professor

Richard Heyman and Anne Daigle Endowed Developmental Chair

Areas of interest: BAF chromatin remodeling complex and the role of chromatin regulators in cancer

Disease models: BAF subunit mutant solid tumors such as medulloblastomas

Daniel Hollern, PhD

Assistant Professor

Areas of interest: triple-negative breast cancer, immune cell dynamics, functional genomics

Disease models: breast cancer

Tony Hunter, PhD

American Cancer Society Professor

Renato Dulbecco Chair

Areas of interest: phosphorylation, ubiquitylation and sumoylation in cancer

Disease models: cancer kinome, pancreatic cancer, glioblastoma, prostate cancer

Gerald Joyce, MD, PhD

President

Professor

Jack H. Skirball Center for Chemical Biology and Proteomics

Areas of interest: RNA evolution, RNA biology

Disease models: high throughput screening and development of small molecules and biologic therapeutics

Susan Kaech, PhD

Professor and Director

NOMIS Chair

Areas of interest: T cell function, tumor immunology

Disease models: immune checkpoint inhibitors in model systems

Jan Karlseder, PhD

Professor

Donald and Darlene Shiley Chair

Areas of interest: telomere function and dysregulation in cancer cells

Disease models: combined treatment of cancer with mitotic inhibitors (Taxol, Velcade and Vinblastine) and PARP inhibitors

Pallav Kosuri, PhD

Assistant Professor

Integrative Biology Laboratory

Areas of interest: DNA topography, RNA transcriptomics, chromatin

Disease models: mechanical and cellular architecture

Julie Law, PhD

Associate Professor

Plant Molecular and Cellular Biology Laboratory

Areas of interest: DNA methylation; epigenome in both agriculture and human health

Disease models: Arabidopsis thaliana

Greg Lemke, PhD

Professor

Françoise Gilot-Salk Chair

Areas of interest: TAM receptor tyrosine kinase signaling in the immune system

Disease models: myeloid leukemia, metastatic lung cancer, renal cell carcinoma, prostatic carcinoma, breast cancer, and gastric cancer

Dmitry Lyumkis, PhD

Associate Professor

Hearst Foundation Developmental Chair

Areas of interest: decoding structures of macromolecular assembly using CryoEMDisease models: cancer, inflammation

Disease models: cancer, inflammation

Graham McVicker, PhD

Associate Professor

Frederick B. Rentschler Developmental Chair

Areas of interest: human genetic variation impacting immune system and cancer

Disease models: leukemias, pediatric blood cancers

Christian Metallo, PhD

Professor

Daniel and Martina Lewis Chair

Areas of interest: systems-based modeling to study metabolic regulation/flux in cells, tissues, and animals; stable isotope tracers

Disease models: cancer metabolism, metabolic syndrome and obesity, stem cell biology

Marc Montminy, MD, PhD

Professor

J.W. Kieckhefer Foundation Chair

Areas of interest: CRTC family transcriptional coactivators and glucose homeostasis

Disease models: insulin signaling and cancer, diabetes

Joseph Noel, PhD

Professor and Director

Arthur and Julie Woodrow Chair

Areas of interest: biosynthetic enzyme engineering

Disease models: anti-cancer agents

Clodagh O'Shea, PhD

Professor

Wicklow Chair

Areas of interest: oncolytic adenoviruses, adenovirus genome engineering and E4-ORF3 function

Disease models: tumor-selective oncolytic viral therapy

Satchidananda Panda, PhD

Professor

Rita and Richard Atkinson Chair

Areas of interest: circadian rhythms and metabolism

Disease models: colon, endometrial, breast and liver cancer

Talmo Pereira, PhD

Salk Fellow

Areas of interest: machine learning, animal behavior

Disease models: motor control, single cell states throughout development and disease

Samuel Pfaff, PhD

Professor

Benjamin H. Lewis Chair

Areas of interest: signaling principles that control specification/connectivity of spinal neurons in locomotion

Disease models: post-polio syndrome

Alan Saghatelian, PhD

Professor

Dr. Frederik Paulsen Chair

Areas of interest: mass spectrometry strategies for detection of metabolites and peptides

Disease models: global lipid and peptide profiling of cancer (colon, lung cancer) and metabolic diseases

Gerald Shadel, PhD

Professor

Audrey Geisel Chair in Biomedical Science

Areas of interest: role of mitochondria in disease, aging, and immune function

Disease models: mitochondrial function in different cancers and neurodegenerative disorders

Reuben Shaw, PhD

Professor

William R. Brody Chair

Areas of interest: metabolic changes and vulnerabilities in cancer, autophagy, starvation signaling

Disease models: lung cancer, pancreatic cancer, hamartoma syndromes

Christina Towers, PhD

Assistant Professor

Areas of interest: cellular homeostasis in cancer via canonical and non-canonical autophagy pathways pathways; mitophagy

Disease models: cancer, neurodegeneration, infection

Geoffrey Wahl, PhD

Professor

Areas of interest: p53 regulation, normal stem cells and stem-like cells in breast cancer, tumor heterogeneity

Disease models: breast cancer

Ye Zheng, PhD

Professor

Areas of interest: molecular mechanisms of regulatory and effector T cells function

Disease models: autoimmune and metabolic diseases, tumors