Home - Conquering Cancer Initiative - Meet the Scientists
Janelle Ayres, PhD
Professor
Salk Institute Legacy Chair
Areas of interest: inflammation and pathobionts in the gut microbiota
Disease models: pathobionts, colorectal cancer
Jesse Dixon, MD, PhD
Assistant Professor
Areas of interest: 3d genomic control
Disease models: pediatric leukemia, colon cancer
Joseph Ecker, PhD
Salk International Council Chair in Genetics
Areas of interest: epigenomics of stem cells and cancer cells
Disease models: breast cancer
Dannielle Engle, PhD
Regulatory Biology Laboratory
Helen McLoraine Developmental Chair in Neurobiology
Areas of interest: organoid technology, glycosylation in cancer, early detection/treatment, mouse models
Disease models: pancreatic cancer, pancreatitis
Ronald Evans, PhD
Professor and Director
March of Dimes Chair in Molecular and Developmental Biology
Areas of interest: nuclear receptor function in metabolism and cancer
Disease models: pancreatic cancer, colon cancer, diabetes
Rusty Gage, PhD
Laboratory of Genetics
Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease
Areas of interest: neurogenesis, adult stem cells, iPSCs
Disease models: human aging and age-associated diseases
Diana Hargreaves, PhD
Associate Professor
Richard Heyman and Anne Daigle Endowed Developmental Chair
Areas of interest: BAF chromatin remodeling complex and the role of chromatin regulators in cancer
Disease models: BAF subunit mutant solid tumors such as medulloblastomas
Daniel Hollern, PhD
Areas of interest: triple-negative breast cancer, immune cell dynamics, functional genomics
Tony Hunter, PhD
American Cancer Society Professor
Renato Dulbecco Chair
Areas of interest: phosphorylation, ubiquitylation and sumoylation in cancer
Disease models: cancer kinome, pancreatic cancer, glioblastoma, prostate cancer
Gerald Joyce, MD, PhD
President
Jack H. Skirball Center for Chemical Biology and Proteomics
Areas of interest: RNA evolution, RNA biology
Disease models: high throughput screening and development of small molecules and biologic therapeutics
Susan Kaech, PhD
NOMIS Chair
Areas of interest: T cell function, tumor immunology
Disease models: immune checkpoint inhibitors in model systems
Jan Karlseder, PhD
Donald and Darlene Shiley Chair
Areas of interest: telomere function and dysregulation in cancer cells
Disease models: combined treatment of cancer with mitotic inhibitors (Taxol, Velcade and Vinblastine) and PARP inhibitors
Pallav Kosuri, PhD
Integrative Biology Laboratory
Areas of interest: DNA topography, RNA transcriptomics, chromatin
Disease models: mechanical and cellular architecture
Julie Law, PhD
Plant Molecular and Cellular Biology Laboratory
Areas of interest: DNA methylation; epigenome in both agriculture and human health
Disease models: Arabidopsis thaliana
Greg Lemke, PhD
Françoise Gilot-Salk Chair
Areas of interest: TAM receptor tyrosine kinase signaling in the immune system
Disease models: myeloid leukemia, metastatic lung cancer, renal cell carcinoma, prostatic carcinoma, breast cancer, and gastric cancer
Dmitry Lyumkis, PhD
Hearst Foundation Developmental Chair
Areas of interest: decoding structures of macromolecular assembly using CryoEMDisease models: cancer, inflammation
Disease models: cancer, inflammation
Graham McVicker, PhD
Frederick B. Rentschler Developmental Chair
Areas of interest: human genetic variation impacting immune system and cancer
Disease models: leukemias, pediatric blood cancers
Christian Metallo, PhD
Daniel and Martina Lewis Chair
Areas of interest: systems-based modeling to study metabolic regulation/flux in cells, tissues, and animals; stable isotope tracers
Disease models: cancer metabolism, metabolic syndrome and obesity, stem cell biology
Marc Montminy, MD, PhD
J.W. Kieckhefer Foundation Chair
Areas of interest: CRTC family transcriptional coactivators and glucose homeostasis
Disease models: insulin signaling and cancer, diabetes
Joseph Noel, PhD
Arthur and Julie Woodrow Chair
Areas of interest: biosynthetic enzyme engineering
Disease models: anti-cancer agents
Clodagh O'Shea, PhD
Wicklow Chair
Areas of interest: oncolytic adenoviruses, adenovirus genome engineering and E4-ORF3 function
Disease models: tumor-selective oncolytic viral therapy
Satchidananda Panda, PhD
Rita and Richard Atkinson Chair
Areas of interest: circadian rhythms and metabolism
Disease models: colon, endometrial, breast and liver cancer
Talmo Pereira, PhD
Salk Fellow
Areas of interest: machine learning, animal behavior
Disease models: motor control, single cell states throughout development and disease
Samuel Pfaff, PhD
Benjamin H. Lewis Chair
Areas of interest: signaling principles that control specification/connectivity of spinal neurons in locomotion
Disease models: post-polio syndrome
Alan Saghatelian, PhD
Dr. Frederik Paulsen Chair
Areas of interest: mass spectrometry strategies for detection of metabolites and peptides
Disease models: global lipid and peptide profiling of cancer (colon, lung cancer) and metabolic diseases
Gerald Shadel, PhD
Audrey Geisel Chair in Biomedical Science
Areas of interest: role of mitochondria in disease, aging, and immune function
Disease models: mitochondrial function in different cancers and neurodegenerative disorders
Reuben Shaw, PhD
William R. Brody Chair
Areas of interest: metabolic changes and vulnerabilities in cancer, autophagy, starvation signaling
Disease models: lung cancer, pancreatic cancer, hamartoma syndromes
Christina Towers, PhD
Areas of interest: cellular homeostasis in cancer via canonical and non-canonical autophagy pathways pathways; mitophagy
Disease models: cancer, neurodegeneration, infection
Geoffrey Wahl, PhD
Areas of interest: p53 regulation, normal stem cells and stem-like cells in breast cancer, tumor heterogeneity
Ye Zheng, PhD
Areas of interest: molecular mechanisms of regulatory and effector T cells function
Disease models: autoimmune and metabolic diseases, tumors
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