NCI Cancer Center

Research

Salk Institute for Biological Studies - NCI Cancer Center - Research

Research



Transcriptional and Epigenetic Control of Cancer

Ronald Evans (Program Leader) Susan Kaech (Program Leader)

Program Members:

Jesse Dixon
Area of interest:
Disease models:
Website: http://dixon.salk.edu/

Joseph Ecker
Area of interest: epigenomics of stem cells and cancer cells
Disease models: breast cancer
Website: https://www.salk.edu/scientist/joseph-ecker/

Beverly Emerson
Area of interest: transcriptional regulation of tumor suppressor genes
Disease models: breast cancer
Website: https://www.salk.edu/scientist/beverly-emerson/

Ronald Evans (Program Leader)
Area of interest: nuclear receptor function in metabolism and cancer
Disease models: pancreatic cancer, colon cancer, diabetes
Website: https://www.salk.edu/scientist/ronald-evans/

Diana Hargreaves
Area of interest: BAF chromatin remodeling complex and the role of chromatin regulators in cancer
Disease models: BAF subunit mutant solid tumors such as medulloblastomas
Website: https://www.salk.edu/scientist/diana-hargreaves/

Martin Hetzer
Area of interest: nuclear pore protein function, micronuclei and cancer
Disease models: AML
Website: https://www.salk.edu/scientist/martin-hetzer/

Patrick Hsu
Area of interest:
Disease models:
Website: http://hsu.salk.edu/

Katherine Jones
Area of interest: Wnt/β-catenin signaling pathways and transcriptional regulation
Disease models: colon cancer
Website: https://www.salk.edu/scientist/katherine-jones/

Susan Kaech (Program Leader)
Area of interest:
Disease models:
Website:

Jan Karlseder
Area of interest: telomere function and dysregulation in cancer cells
Disease models: combined treatment of cancer with mitotic inhibitors (Taxol, Velcade and Vinblastine) and PARP inhibitors
Website: https://www.salk.edu/scientist/jan-karlseder/

Christopher Kintner
Area of interest: genetic pathways that drive multiciliate cell formation
Disease models: centriole assembly dysregulation and chromosomal instability in tumor cells
Website: https://www.salk.edu/scientist/christopher-kintner/

Julie Law
Area of interest: epigenetic gene regulation and chromatin binding proteins
Disease model:
Website: https://www.salk.edu/scientist/julie-law/

Vicki Lundblad
Area of interest: telomeres and telomerase regulation in yeast
Disease models: therapeutic targets for telomerase inhibition in cancer
Website: https://www.salk.edu/scientist/vicki-lundblad/

Graham McVicker
Area of interest:
Disease models:
Website: https://www.salk.edu/scientist/graham-mcvicker/

Marc Montminy
Area of interest: CRTC family transcriptional coactivators and glucose homeostasis
Disease models: insulin signaling and cancer, diabetes
Website: https://www.salk.edu/scientist/marc-montminy/

Joseph Noel
Area of interest: biosynthetic enzyme engineering
Disease models: anti-cancer agents
Website: https://www.salk.edu/scientist/joseph-noel/

Geoffrey Wahl
Area of interest: p53 regulation, normal stem cells and stem-like cells in breast cancer, tumor heterogeneity
Disease models: breast cancer
Website: https://www.salk.edu/scientist/geoffrey-m-wahl/

Ye Zheng
Area of interest: T cell subset function in cancer and metabolism
Disease model; autoimmune disease and cancer
Website: https://www.salk.edu/scientist/ye-zheng/


Animal Models and Therapeutics

Clodagh O’Shea (Program Leader) Inder Verma (Program Leader)

Program Members:

Janelle Ayres
Area of interest: inflammation and pathobionts in the gut microbiota
Disease models: pathobionts, colorectal cancer
Website: https://www.salk.edu/scientist/janelle-ayres/

Rusty Gage
Area of interest: stem cell self renewal and mobile elements in the nervous system and cancer
Disease models: ataxia telangiectasia, neurodegenerative disease
Website: https://www.salk.edu/scientist/rusty-gage/

Tony Hunter
Area of interest: phosphorylation, ubiquitylation and sumoylation in cancer
Disease models: cancer kinome, pancreatic cancer, glioblastoma, prostate cancer
Website: https://www.salk.edu/scientist/tony-hunter/

Juan Carlos Izpisua Belmonte
Area of interest: mechanisms underlying stem cell biology in cancer and regeneration
Disease models: genetic aberrations common to iPSCs that correlate with cancer genomic alterations
Website: https://www.salk.edu/scientist/juan-carlos-izpisua-belmonte/

Gerald Joyce
Area of interest:
Disease models;
Website: https://www.salk.edu/scientist/gerald-joyce/

Kuo-Fen Lee
Area of interest: integration of RTK and GPCR signaling pathways during mammalian development
Disease models: prostate, breast and non-small cell lung cancers
Website: https://www.salk.edu/scientist/kuo-fen-lee/

Greg Lemke
Area of interest: TAM receptor tyrosine kinase signaling in the immune system
Disease models: myeloid leukemia, metastatic lung cancer, renal cell carcinoma, prostatic carcinoma, breast cancer, and gastric cancer
Website: https://www.salk.edu/scientist/greg-lemke/

Björn Lillemeier
Area of interest: T cell receptor signaling mechanisms
Disease models: with immune cell cancers, including chronic lymphocytic leukemia
Website: https://www.salk.edu/scientist/bjorn-lillemeier/

Dmitry Lyumkis
Area of interest:
Disease models;
Website: http://lyumkis.salk.edu/

Axel Nimmerjahn
Area of interest: imaging tools to study glial cell dynamics in the live brain, and in glioblastomas
Disease models: glioblastoma
Website: https://www.salk.edu/scientist/axel-nimmerjahn/

Clodagh O’Shea (Program Leader)
Area of interest: oncolytic adenoviruses, adenovirus genome engineering and E4-ORF3 function
Disease models: tumor-selective oncolytic viral therapy
Website: https://www.salk.edu/scientist/clodagh-oshea/

Satchidananda Panda
Area of interest: circadian rhythms and metabolism
Disease models: colon, endometrial, breast and liver cancer
Website: https://www.salk.edu/scientist/satchidananda-panda/

Samuel Pfaff
Area of interest: signaling principles that control specification/connectivity of spinal neurons in locomotion
Disease models: post-polio syndrome
Website: https://www.salk.edu/scientist/samuel-pfaff/

Alan Saghatelian
Area of interest: signaling principles that control specification/connectivity of spinal neurons in locomotion
Disease model: Global lipid and peptide profiling of cancer and metabolic diseases
Website: https://www.salk.edu/scientist/alan-saghatelian/

Gerald Shadel
Area of interest:
Disease models:
Website:

Reuben Shaw
Area of interest: AMPK in cancer and metabolism
Disease models: sporadic lung cancers (squamous and adenocarcinoma)
Website: https://www.salk.edu/scientist/reuben-shaw/

Edward Stites
Area of interest:
Disease models:
Website: https://www.salk.edu/scientist/edward-stites/

Inder Verma (Program Leader)
Area of interest: mouse models of cancer and lentivirus vector development
Disease models: inflammation, breast, prostate and ovarian cancer, glioblastoma
Website: https://www.salk.edu/scientist/inder-verma/