Salk's Cancer Center

Reuben Shaw, PhD

Professor

William R. Brody Chair

Areas of interest: metabolic changes and vulnerabilities in cancer, autophagy, starvation signaling

Disease models: lung cancer, pancreatic cancer, hamartoma syndromes

Susan Kaech, PhD

Professor and Director

NOMIS Chair

Areas of interest: T cell function, tumor immunology

Disease models: immune checkpoint inhibitors in model systems

Ronald Evans, PhD

Professor and Director

March of Dimes Chair in Molecular and Developmental Biology

Areas of interest: nuclear receptor function in metabolism and cancer

Disease models: pancreatic cancer, colon cancer, diabetes

Geoffrey Wahl, PhD

Professor

Areas of interest: p53 regulation, normal stem cells and stem-like cells in breast cancer, tumor heterogeneity

Disease models: breast cancer

Dmitry Lyumkis, PhD

Associate Professor

Hearst Foundation Developmental Chair

Areas of interest: decoding structures of macromolecular assembly using CryoEMDisease models: cancer, inflammation

Disease models: cancer, inflammation

Gerald Shadel, PhD

Professor

Audrey Geisel Chair in Biomedical Science

Areas of interest: role of mitochondria in disease, aging, and immune function

Disease models: mitochondrial function in different cancers and neurodegenerative disorders

Tony Hunter, PhD

American Cancer Society Professor

Renato Dulbecco Chair

Areas of interest: phosphorylation, ubiquitylation and sumoylation in cancer

Disease models: cancer kinome, pancreatic cancer, glioblastoma, prostate cancer

Leona Flores, PhD

Diana Hargreaves, PhD

Associate Professor

Richard Heyman and Anne Daigle Endowed Developmental Chair

Areas of interest: BAF chromatin remodeling complex and the role of chromatin regulators in cancer

Disease models: BAF subunit mutant solid tumors such as medulloblastomas

Jan Karlseder, PhD

Professor

Donald and Darlene Shiley Chair

Areas of interest: telomere function and dysregulation in cancer cells

Disease models: combined treatment of cancer with mitotic inhibitors (Taxol, Velcade and Vinblastine) and PARP inhibitors

Janelle Ayres, PhD

Professor

Salk Institute Legacy Chair

Areas of interest: inflammation and pathobionts in the gut microbiota

Disease models: pathobionts, colorectal cancer

Christian Metallo, PhD

Professor

Daniel and Martina Lewis Chair

Areas of interest: systems-based modeling to study metabolic regulation/flux in cells, tissues, and animals; stable isotope tracers

Disease models: cancer metabolism, metabolic syndrome and obesity, stem cell biology

Jesse Dixon, MD, PhD

Assistant Professor

Areas of interest: 3d genomic control

Disease models: pediatric leukemia, colon cancer

Joseph Ecker, PhD

Professor

Salk International Council Chair in Genetics

Areas of interest: epigenomics of stem cells and cancer cells

Disease models: breast cancer

Dannielle Engle, PhD

Assistant Professor

Regulatory Biology Laboratory

Helen McLoraine Developmental Chair in Neurobiology

Areas of interest: organoid technology, glycosylation in cancer, early detection/treatment, mouse models

Disease models: pancreatic cancer, pancreatitis

Rusty Gage, PhD

Professor

Laboratory of Genetics

Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease

Areas of interest: neurogenesis, adult stem cells, iPSCs

Disease models: human aging and age-associated diseases

Daniel Hollern, PhD

Assistant Professor

Areas of interest: triple-negative breast cancer, immune cell dynamics, functional genomics

Disease models: breast cancer

Gerald Joyce, MD, PhD

President

Professor

Jack H. Skirball Center for Chemical Biology and Proteomics

Areas of interest: RNA evolution, RNA biology

Disease models: high throughput screening and development of small molecules and biologic therapeutics

Pallav Kosuri, PhD

Assistant Professor

Integrative Biology Laboratory

Areas of interest: DNA topography, RNA transcriptomics, chromatin

Disease models: mechanical and cellular architecture

Julie Law, PhD

Associate Professor

Plant Molecular and Cellular Biology Laboratory

Areas of interest: DNA methylation; epigenome in both agriculture and human health

Disease models: Arabidopsis thaliana

Greg Lemke, PhD

Professor

Françoise Gilot-Salk Chair

Areas of interest: TAM receptor tyrosine kinase signaling in the immune system

Disease models: myeloid leukemia, metastatic lung cancer, renal cell carcinoma, prostatic carcinoma, breast cancer, and gastric cancer

Uri Manor, PhD

Assistant Research Professor

Director of the Waitt Advanced Biophotonics Core

Areas of interest: mitochondria dynamics

Disease models: neurodegeneration, hearing loss, cancer and metabolic disorders

Graham McVicker, PhD

Associate Professor

Frederick B. Rentschler Developmental Chair

Areas of interest: human genetic variation impacting immune system and cancer

Disease models: leukemias, pediatric blood cancers

Marc Montminy, MD, PhD

Professor

J.W. Kieckhefer Foundation Chair

Areas of interest: CRTC family transcriptional coactivators and glucose homeostasis

Disease models: insulin signaling and cancer, diabetes

Joseph Noel, PhD

Professor and Director

Arthur and Julie Woodrow Chair

Areas of interest: biosynthetic enzyme engineering

Disease models: anti-cancer agents

Clodagh O’Shea, PhD

Professor

Wicklow Chair

Areas of interest: oncolytic adenoviruses, adenovirus genome engineering and E4-ORF3 function

Disease models: tumor-selective oncolytic viral therapy

Satchidananda Panda, PhD

Professor

Rita and Richard Atkinson Chair

Areas of interest: circadian rhythms and metabolism

Disease models: colon, endometrial, breast and liver cancer

Talmo Pereira, PhD

Salk Fellow

Areas of interest: machine learning, animal behavior

Disease models: motor control, single cell states throughout development and disease

Samuel Pfaff, PhD

Professor

Benjamin H. Lewis Chair

Areas of interest: signaling principles that control specification/connectivity of spinal neurons in locomotion

Disease models: post-polio syndrome

Alan Saghatelian, PhD

Professor

Dr. Frederik Paulsen Chair

Areas of interest: mass spectrometry strategies for detection of metabolites and peptides

Disease models: global lipid and peptide profiling of cancer (colon, lung cancer) and metabolic diseases

Christina Towers, PhD

Assistant Professor

Areas of interest: cellular homeostasis in cancer via canonical and non-canonical autophagy pathways pathways; mitophagy

Disease models: cancer, neurodegeneration, infection

Ye Zheng, PhD

Professor

Areas of interest: molecular mechanisms of regulatory and effector T cells function

Disease models: autoimmune and metabolic diseases, tumors