LA JOLLA—Can you tell the smell of a rose from the scent of a lilac? If so, you have your brain’s piriform cortex to thank. Compared to many parts of the brain, the piriform cortex—which lets animals and humans process information about smells—looks like a messy jumble of connections between cells called neurons. Now, Salk Institute researchers have illuminated how the randomness of the piriform cortex is actually critical to how the brain distinguishes between similar odors.
LA JOLLA—A new study from the Salk Institute has found that mice that have their microbiomes depleted with antibiotics have decreased levels of glucose in their blood and better insulin sensitivity. The research has implications for understanding the role of the microbiome in diabetes. It also could lead to better insight into the side effects seen in people who are being treated with high levels of antibiotics. The study appeared in the journal Nature Communications on July 20, 2018.
LA JOLLA—Associate Professor Janelle Ayres is the recipient of a $1 million grant from the W. M. Keck Foundation to study new ways to treat deadly infections including sepsis and the flu, both of which require novel therapies beyond antibiotics and antivirals to effectively combat.
LA JOLLA—One reason we’re supposed to eat a variety of colorful fruits and vegetables is because they contain nutritious compounds called antioxidants. These molecules counteract the damage to our bodies from harmful products of normal cells called reactive oxygen species (ROS).
LA JOLLA—Only some of us have satellite TV in our homes, but all of us have satellite DNA in cells in our bodies. Working copies of satellite DNA (called satellite RNAs) are high in certain types of cancer, such as breast and ovarian. But whether they cause cancer or merely coincide with it has been unclear.
LA JOLLA—Driving to work, typing an email or playing a round of golf—people perform actions such as these throughout the day. But neuroscientists are still unsure how the brain orchestrates complex actions or switches to a new action—behaviors that are impaired in disorders such as Parkinson’s disease or obsessive-compulsive disorder (OCD).
LA JOLLA—Salk Associate Professor Janelle Ayres has been named one of three winners of the Blavatnik National Awards for Young Scientists, one of the world’s largest unrestricted prizes for early career scientists. Ayres, the laureate in the life sciences category, will receive $250,000 for her pioneering research in physiology and the study of the how bacteria interact with humans. Ayres’ work is revolutionizing our understanding of host-pathogen interactions and has the potential to solve one of the greatest current public health threats: anti-microbial resistance.
LA JOLLA—Salk Institute scientists Ronald Evans, Diana Hargreaves, Tony Hunter, Graham McVicker and Geoffrey Wahl are among the first wave of researchers to receive funding from Padres Pedal the Cause, one of one of the largest stand-alone cancer fundraising events in San Diego. The nonprofit raised $2.4 million for cancer research in November 2017, thanks to the efforts of more than 3,000 bicycle riders, sponsors, volunteers and donors.
LA JOLLA—Eiman Azim, an assistant professor in Salk’s Molecular Neurobiology Laboratory, has received a McKnight Scholar Award from the McKnight Foundation. The award, which totals $225,000 over three years, encourages neuroscientists at early stages of their careers to focus on disorders of learning and memory. Each year it is awarded to no more than six neuroscientists.
LA JOLLA—Salk American Cancer Society Professor Tony Hunter has been awarded the 2018 Tang Prize in Biopharmaceutical Science.
LA JOLLA—Saket Navlakha, an assistant professor in Salk’s Integrative Biology Laboratory, is one of 22 researchers to be named a 2018 Pew Scholar in the Biomedical Sciences. Each scholar receives $300,000 over four years. Additionally, Navlakha is one of a subset of five Pew Scholars selected for support by the Kathryn W. Davis Peace by Pieces Fund, which focuses on investigating health challenges in the brain as it ages.
On June 11, 2018, Salk’s Board of Trustees met to discuss the findings of the Institute’s investigation into allegations against Dr. Inder Verma. Our commitment from the outset has been to undertake an investigatory process that is thorough and impartial and to take action as appropriate. Although we will not comment on the details of this confidential personnel matter, we wanted to share with you the outcome of this process.
LA JOLLA—The Salk Institute has been ranked one of the top 5 nonprofit institutions in the world focused on the life sciences and one of the top 10 nonprofits generally, according to a report known as the Nature Index and released by Springer Nature on June 7, 2018. The rankings are based on Nature Index data from 1 January 2017 to 31 December 2017.
LA JOLLA—One of the many challenges in treating HIV is that the virus can lie dormant in cells, quietly evading immune detection until it suddenly roars to life without warning and begins replicating furiously. Salk Institute researchers discovered a small molecule called JIB-04 that destroys the HIV protein called Tat, responsible for revving up the virus.
LA JOLLA—Associate Professor Janelle Ayres is one of 31 US finalists selected to compete for the world’s largest unrestricted prizes for early career researchers, the Blavatnik National Awards for Young Scientists. The Blavatnik National Awards recognize both the past accomplishments and the future promise of the most talented scientific and engineering researchers aged 42 years and younger at America’s top academic and research institutions.
LA JOLLA—Defective energy production in old neurons might explain why our brains are so prone to age-related diseases. Salk researchers used a new method to discover that cells from older individuals had impaired mitochondria—the power stations of cells—and reduced energy production. A better understanding of the effects of aging on mitochondria could reveal more about the link between mitochondrial dysfunction and age-related brain diseases, such as Alzheimer's and Parkinson's.
LA JOLLA—The Salk Institute has received $1.5 million for research into the cellular underpinnings of Alzheimer’s disease from NANOS Co. Ltd. (“NANOS”), a company based in the Republic of Korea. The funds will establish a dedicated laboratory space called the NANOS Alzheimer’s Disease Stem Cell Suite, which will serve as a cell bank focused on Alzheimer’s. This cell bank will house both stem cells and somatic (body) cells from human donors, critical for analysis and testing of therapeutic drugs.
LA JOLLA—The Salk Institute for Biological Studies announced the hiring of Steven Johnson as its Senior Director of Communications to manage the communications and multimedia relations teams and to serve as the communications liaison to the Salk President.
LA JOLLA—As part of its efforts to continuously attract and retain top talent, the Salk Institute has appointed neuroscientist Margarita Behrens to the newly created position of Research Professor, which carries non-tenure faculty status. Behrens, who has been a staff scientist in Salk’s Computational Neurobiology Laboratory (CNL) since 2009, will lead her own research group within the CNL, where she will carry out independent research projects and continue to collaborate on studies with the Institute’s other world-renowned neuroscience faculty.
LA JOLLA—More than 27 million people in the United States are living with type 2 diabetes, according to the Centers for Disease Control and Prevention. As the population ages and a growing percentage of people become overweight or obese, that number is expected to increase.
