LA JOLLA—Salk researchers have mapped the genomes and epigenomes of genetically modified plant lines with the highest resolution ever to reveal exactly what happens at a molecular level when a piece of foreign DNA is inserted. Their findings, published in the journal PLOS Genetics on January 18, 2019, elucidate the routine methods used to modify plants, and offer new ways to more effectively minimize potential off-target effects.
LA JOLLA—The incidence of some neurological diseases—especially those related to aging, such as Alzheimer’s and Parkinson’s diseases—is increasing. To better understand these conditions and evaluate potential new treatments, researchers need accurate models that they can study in the lab.
LA JOLLA—Salk scientist 萨凯特·纳夫拉克哈 has received a CAREER award from the National Science Foundation (NSF) totaling more than $1 million over the next five years. The CAREER award supports faculty who exemplify the role of teacher/scholars through outstanding research, excellent education and the integration of education and research within the context of the mission of their organizations.
拉霍亚—自闭症谱系障碍（ASD）是一种相对常见的发育障碍，影响沟通和行为，在美国约有五十九分之一的儿童患有此病，, 根据美国疾病控制与预防中心. 尽管它很普遍，但其病因以及最佳治疗方法仍不清楚。.
LA JOLLA—The Board of Trustees of the Salk Institute, in consultation with the faculty and a search committee comprised of Board members, voted to extend a new five-year term to 鲁斯蒂·盖奇, who became the Institute’s President a year ago, expanding his tenure through 2024.
LA JOLLA—When we perceive the world around us, certain objects appear to be more noticeable than others, depending on what we do. For example, when we view a forest-covered mountain from a distance, the forest looks like a large green carpet. But as we get closer, we start noticing the individual trees, and the forest fades to the background. What happens in the brain as our experience changes so drastically?
LA JOLLA—Doctors have long observed that biological age and chronological age are not always one and the same. A 55-year-old may exhibit many signs of old age and have numerous age-related diseases, whereas an 80-year-old may be healthy and robust. While diet, physical activity and other factors play a role, there are many contributors as to why and how some people age better than others. Those contributors remain poorly understood.
拉霍亚辛金, an associate professor in Salk’s Molecular Neurobiology Laboratory, has been selected as one of four scientists to receive the McKnight Memory and Cognitive Disorders award from the McKnight Endowment Fund for Neuroscience to study how the brain learns, remembers and executes actions. The award, which comprises $300,000 over three years, includes participation in the annual McKnight Conference on Neuroscience.
拉霍亚—副教授 贾内尔·艾尔斯 has been awarded $1.8 million over two years by the NOMIS Foundation to study health as an active process in which microbes—including the trillions of microorganisms that call the human body home—initiate interactions that promote the health of the host.
LA JOLLA—For the eighth consecutive time, the Salk Institute’s strong financial health and continuing commitment to accountability and transparency have earned it a coveted 4-star (out of 4 stars) rating from Charity Navigator, America’s largest independent charity and nonprofit evaluator.
LA JOLLA—Salk Professors Joanne Chory, Joseph Ecker and Rusty Gage have once again been named to the Highly Cited Researchers list by Clarivate Analytics (formerly Thomson Reuters). The list selects researchers for “exceptional research performance” demonstrated by the production of multiple highly cited papers that rank in the top 1 percent by citations for field and year. Additionally, among the 4,058 researchers named as Highly Cited, Ecker is one of 194 researchers appearing in two separate categories: “plant and animal science,” as well as “molecular biology and genetics.”
拉霍亚尼古拉·艾伦, an assistant professor in Salk’s Molecular Neurobiology Laboratory, has received a five-year, $2.5 million Ben Barres Early Career Acceleration Award from the Chan Zuckerberg Initiative (CZI), as part of a $51.95 million effort launching the CZI Neurodegeneration Challenge Network. This new network brings together experimental scientists from diverse research fields—neuroscience, cell biology, biochemistry, immunology and genomics—along with computational biologists and physicians, to understand the underlying causes of disorders such as Alzheimer’s, Parkinson’s, Huntington’s disease and ALS.
LA JOLLA—Embryonic stem cells (ESCs) are the very definition of being full of potential, given that they can become any type of cell in the body. Once they start down any particular path toward a type of tissue, they lose their unlimited potential. Scientists have been trying to understand why and how this happens in order to create regenerative therapies that can, for example, coax a person’s own cells to replace damaged or diseased organs.
LA JOLLA—It might seem like fruit flies would have nothing in common with computers, but new research from the Salk Institute reveals that the two identify novel information in similar ways. The work, which appeared in Proceedings of the National Academy of Sciences (PNAS) on December 3, 2018, not only sheds light on an important neurobiological problem—how organisms detect new odors—but could also improve algorithms for novelty detection in computer science.
拉霍亚——索尔克研究所教授兼霍华德·休斯医学研究所研究员 罗纳德·埃文斯, 萨尔克研究所基因表达实验室主任，也被选为世界上最大的综合性科学学会——美国科学促进协会（AAAS）2018年度会员。根据该协会的表彰词，AAAS尤其肯定了他对类固醇和孤儿受体信号传导的发现，揭示了已知和新型生理学、新陈代谢和疾病分支的“宝库”。.
LA JOLLA—For most, the time spent staring at screens—on computers, phones, iPads—constitutes many hours and can often disrupt sleep. Now, Salk Institute researchers have pinpointed how certain cells in the eye process ambient light and reset our internal clocks, the daily cycles of physiological processes known as the circadian rhythm. When these cells are exposed to artificial light late into the night, our internal clocks can get confused, resulting in a host of health issues.
LA JOLLA—Old age is the greatest risk factor for many diseases, including Alzheimer’s disease (AD) and cancer. Geroprotectors are a recently identified class of anti-aging compounds. New Salk research has now identified a unique subclass of these compounds, dubbed geroneuroprotectors (GNPs), which are AD drug candidates and slow the aging process in mice.
LA JOLLA—A team of Salk Institute researchers led by President 鲁斯蒂·盖奇 has been awarded $19.2 million over eight years by the American Heart Association-Allen Initiative in Brain Health and Cognitive Impairment to investigate mechanisms underlying Alzheimer’s disease and aging-related cognitive decline and uncover new therapies. This bold venture will comprehensively analyze interactions between five areas key to brain health: proteins, genes, metabolism, inflammation and epigenetics.
