La Jolla, CA – HIV selectively inserts itself into active areas of a host cell’s genome, Salk Institute researchers have found for the first time. The fact that the virus hooks itself up to areas of the cell’s genome that are busy expressing themselves may help explain why HIV can replicate, or reproduce itself, so rapidly. The findings are being published as the cover article in the Friday, August 23, issue of the journal Cell.
La Jolla, CA – A crucial piece of the puzzle into how the eye becomes wired to the brain has been revealed by scientists at the Salk Institute for Biological Studies in La Jolla, Calif., and UT Southwestern Medical Center at Dallas.
La Jolla, CA – A team led by Salk Institute scientists may have discovered how viruses can “hit and run” a cell’s genetic machinery to trigger cancer and exit without a trace.
La Jolla, CA – In recognition of its deep commitment to Morse High School students, the Salk Institute has been awarded the ‘Exemplary Partnerships Award’ and the ‘Ten-Year Partnerships Award’ by San Diego City Schools.
La Jolla, CA – A team led by Salk Institute scientists has used gene therapy to reverse infertility in male mice. Treated mice produced healthy offspring that did not contain the introduced gene or vector, alleviating concerns that treating infertility via gene therapy would genetically alter any progeny produced from the treatment, as well as their descendants in perpetuity.
La Jolla, CA – A team led by Salk scientists has identified the probable link between the breast cancer drug Herceptin and cardiac failure, one of its common side effects. The results may also explain why a common combination drug regimen including Herceptin is particularly toxic.
La Jolla, CA – Salk Institute scientists have observed for the first time that new cells in the adult brain grow and mature over time, functioning just like any of their neighboring neurons.
La Jolla, CA – According to accepted dogma, the brain responds to sensory experiences somewhat like an electronic bucket brigade, with incoming signals passed from one region to the next in a somewhat linear fashion.
La Jolla, CA – In the first global survey of its kind, scientists at The Salk Institute have isolated a genetic switch that controls how plants growing at different latitudes respond to light. The variation ensures that plants in northern climes near the poles, for example, are more sensitive to light than their counterparts closer to the equator.
La Jolla, CA – Salk scientists have identified a new potential drug target for type II diabetes that may offer a specific treatment to complement existing therapies. The new target, a protein called CREB (for cyclic AMP response binding), acts in a pathway independent of that targeted by the thiazolidinediones, currently considered the most effective drugs for managing the condition.
La Jolla, CA – Salk scientists have created an animal model for autoimmune diseases that closely mirrors the perplexing patterns of symptoms observed in human autoimmunity, including an increased susceptibility of females over males.
La Jolla, CA – Though a rose, carnation or tulip each has its own distinguishing feel, look and smell, they all share one common trait: the flower’s petals adorn its perimeter while the reproductive organs sit in the flower’s center.
La Jolla, CA – Salk Institute scientists have isolated cells from the brains of human cadavers that can grow, divide and form specialized classes of brain cells. Their findings indicate that postmortem tissue may be a potential source of multipotent stem cells, with a variety of uses and applications.
La Jolla, CA – Sometimes nerve is all you need. But nerves have needs, too, including the use of synapses – tiny junctions that coordinate communication between nerves and the muscles they control.
La Jolla, CA – A Salk Institute-led team of scientists has identified a new site on the HIV enzyme integrase for potential drug therapy. Integrase is the only HIV enzyme not targeted by current drugs; reverse transcriptase and protease are blocked by drugs such as AZT and the protease inhibitors.
La Jolla, CA – Whether they’re wings, fins or legs, those appendages generally known as limbs play a critical role for lifting, grasping, moving and other activities needed to sustain life.
La Jolla, CA – Scientists at The Salk Institute have shown that running can boost brain cell survival in animals with neurodegenerative disease.
La Jolla, CA – The first complete genome sequence of a plant appears in the current issue of Nature. Salk Professor Joseph R. Ecker, co-director of one of six contributing sequencing groups, expects the sequence to greatly accelerate efforts to improve the yield and hardiness of crop plants.
La Jolla, CA – Removing Vitamin A from the diets of mice diminishes chemical changes in the brain considered the hallmarks of learning and memory. When vitamin A is added back to their diets, the impairment is reversed.