2022 PUBLICATIONS
Herdy, J.R., Traxler, L., Agarwal, R.K., Karbacher, L., Schlachetzki, J.C.M., Boehnke, L., Zangwill, D., Galasko, D., Glass, C.K., Mertens, J., Gage, F.H. Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease. (2022) Cell Stem Cell. 29(12):1637-1652.e6. DOI: 10.1016/j.stem.2022.11.010
Fu, C., Ngo, J., Zhang, S., Lu, L., Miron, A., Schafer, S., Gage, F.H., Jin, F., Schumacher, F.R., Wynshaw-Boris, A. Novel correlative analysis identifies multiple genomic variations impacting ASD with macrocephaly. (2022) Human Molecular Genetics. DOI: 10.1093/hmg/ddac300
Ronzano, R., Skarlatou, S., Barriga, B.K., Bannatyne, B.A., Bhumbra, G.S., Foster, J.D., Moore, J.D., Lancelin, C., Pocratsky, A.M., Özyurt, M.G., Smith, C.C., Todd, A.J., Maxwell, D.J., Murray, A.J., Pfaff, S.L., Brownstone, R.M., Zampieri, N., Beato, M. Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled. (2022) Elife. 11. DOI: 10.7554/eLife.81976
Wilson, M.N., Thunemann, M., Liu, X., Lu, Y., Puppo, F., Adams, J.W., Kim, J.H., Ramezani, M., Pizzo, D.P., Djurovic, S., Andreassen, O.A., Mansour, A.A., Gage, F.H., Muotri, A.R., Devor, A., Kuzum, D. Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex. (2022) Nature Communications. 13(1):7945. DOI: 10.1038/s41467-022-35536-3
Zhang, H., Rich, P.D., Lee, A.K., Sharpee, T.O. Hippocampal spatial representations exhibit a hyperbolic geometry that expands with experience. (2022) Nature Neuroscience. DOI: 10.1038/s41593-022-01212-4
Sheridan, A., Nguyen, T.M., Deb, D., Lee, W.A., Saalfeld, S., Turaga, S.C., Manor, U., Funke, J. Local shape descriptors for neuron segmentation. (2022) Nature Methods. DOI: 10.1038/s41592-022-01711-z
Shang, F., Wang, S.C., Gongol, B., Han, S.Y., Cho, Y., Schiavon, C.R., Chen, L., Xing, Y., Zhao, Y., Ning, M., Guo, X., He, F., Lei, Y., Wang, L., Manor, U., Marin, T., Chou, K.T., He, M., Huang, P.H., Shyy, J.Y., Malhotra, A. Obstructive Sleep Apnea-induced Endothelial Dysfunction is Mediated by miR-210. (2022) Am J Respir Crit Care Med. DOI: 10.1164/rccm.202202-0394OC
Rungratsameetaweemana, N., Lainscsek, C., Cash, S.S., Garcia, J.O., Sejnowski, T.J., Bansal, K. Brain network dynamics codify heterogeneity in seizure evolution. (2022) Brain Commun. 4(5):fcac234. DOI: 10.1093/braincomms/fcac234
Shrestha, S., Erikson, G., Lyon, J., Spigelman, A.F., Bautista, A., Manning Fox, J.E., Dos Santos, C., Shokhirev, M., Cartailler, J.P., Hetzer, M.W., MacDonald, P.E., Arrojo E Drigo, R. Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress. (2022) Science Advances. 8(40):eabo3932. DOI: 10.1126/sciadv.abo3932
Linker, S.B., Narvaiza, I., Hsu, J.Y., Wang, M., Qiu, F., Mendes, A.P.D., Oefner, R., Kottilil, K., Sharma, A., Randolph-Moore, L., Mejia, E., Santos, R., Marchetto, M.C., Gage, F.H. Human-specific regulation of neural maturation identified by cross-primate transcriptomics. (2022) Current Biology. DOI: 10.1016/j.cub.2022.09.028
Martins, L.F., Brambilla, I., Motta, A., de Pretis, S., Bhat, G.P., Badaloni, A., Malpighi, C., Amin, N.D., Imai, F., Almeida, R.D., Yoshida, Y., Pfaff, S.L., Bonanomi, D. Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity. (2022) Neuron. DOI: 10.1016/j.neuron.2022.09.021
Calabrese, B., Jones, S.L., Shiraishi-Yamaguchi, Y., Lingelbach, M., Manor, U., Svitkina, T.M., Higgs, H.N., Shih, A.Y., Halpain, S. INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury. (2022) Nature Communications. 13(1):6037. DOI: 10.1038/s41467-022-33268-y
van den Hurk, M., Lau, S., Marchetto, M.C., Mertens, J., Stern, S., Corti, O., Brice, A., Winner, B., Winkler, J., Gage, F.H., Bardy, C. Druggable transcriptomic pathways revealed in Parkinson's patient-derived midbrain neurons. (2022) NPJ Parkinsons Dis. 8(1):134. DOI: 10.1038/s41531-022-00400-0
Li, P., Garg, A.K., Zhang, L.A., Rashid, M.S., Callaway, E.M. Cone opponent functional domains in primary visual cortex combine signals for color appearance mechanisms. (2022) Nature Communications. 13(1):6344. DOI: 10.1038/s41467-022-34020-2
Jeng, J.Y., Carlton, A.J., Goodyear, R.J., Chinowsky, C., Ceriani, F., Johnson, S.L., Sung, T.S., Dayn, Y., Richardson, G.P., Bowl, M.R., Brown, S.D.M., Manor, U., Marcotti, W. AAV-mediated rescue of Eps8 expression in vivo restores hair-cell function in a mouse model of recessive deafness (2022) Molecular Therapy-Methods & Clinical Development.:355-370 DOI: https://doi.org/10.1016/j.omtm.2022.07.012
Wang, H., Dey, O., Lagos, W.N., Callaway, E.M. Diversity in spatial frequency, temporal frequency, and speed tuning across mouse visual cortical areas and layers. (2022) Journal of Comparative Neurology. DOI: 10.1002/cne.25404
Pașca, S.P., Arlotta, P., Bateup, H.S., Camp, J.G., Cappello, S., Gage, F.H., Knoblich, J.A., Kriegstein, A.R., Lancaster, M.A., Ming, G.L., Muotri, A.R., Park, I.H., Reiner, O., Song, H., Studer, L., Temple, S., Testa, G., Treutlein, B., Vaccarino, F.M. A nomenclature consensus for nervous system organoids and assembloids. (2022) Nature. 609(7929):907-910. DOI: 10.1038/s41586-022-05219-6
Stern, S., Lau, S., Manole, A., Rosh, I., Percia, M.M., Ben Ezer, R., Shokhirev, M.N., Qiu, F., Schafer, S., Mansour, A.A., Mangan, K.P., Stern, T., Ofer, P., Stern, Y., Diniz Mendes, A.P., Djamus, J., Moore, L.R., Nayak, R., Laufer, S.H., Aicher, A., Rhee, A., Wong, T.L., Nguyen, T., Linker, S.B., Winner, B., Freitas, B.C., Jones, E., Sagi, I., Bardy, C., Brice, A., Winkler, J., Marchetto, M.C., Gage, F.H. Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson's disease patients. (2022) NPJ Parkinsons Dis. 8(1):103. DOI: 10.1038/s41531-022-00366-z
Traxler, L., Herdy, J.R., Stefanoni, D., Eichhorner, S., Pelucchi, S., Szücs, A., Santagostino, A., Kim, Y., Agarwal, R.K., Schlachetzki, J.C.M., Glass, C.K., Lagerwall, J., Galasko, D., Gage, F.H., D'Alessandro, A., Mertens, J. Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease. (2022) Cell Metabolism. DOI: 10.1016/j.cmet.2022.07.014
Ramirez, M.A., Ninoyu, Y., Miller, C., Andrade, L.R., Edassery, S., Bomba-Warczak, E., Ortega, B., Manor, U., Rutherford, M.A., Friedman, R.A., Savas, J.N. Cochlear ribbon synapse maturation requires Nlgn1 and Nlgn3. (2022) iScience. 25(8):104803. DOI: 10.1016/j.isci.2022.104803
Ghaninia, M., Zhou, Y., Knauer, A.C., Schiestl, F.P., Sharpee, T.O., Smith, B.H. Hyperbolic odorant mixtures as a basis for more efficient signaling between flowering plants and bees. (2022) PLOS One. 17(7):e0270358. DOI: 10.1371/journal.pone.0270358
van Niekerk, E.A., Kawaguchi, R., Marques de Freria, C., Groeniger, K., Marchetto, M.C., Dupraz, S., Bradke, F., Geschwind, D.H., Gage, F.H., Tuszynski, M.H. Methods for culturing adult CNS neurons reveal a CNS conditioning effect. (2022) Cell Rep Methods. 2(7):100255. DOI: 10.1016/j.crmeth.2022.100255
Bae, T., Fasching, L., Wang, Y., Shin, J.H., Suvakov, M., Jang, Y., Norton, S., Dias, C., Mariani, J., Jourdon, A., Wu, F., Panda, A., Pattni, R., Chahine, Y., Yeh, R., Roberts, R.C., Huttner, A., Kleinman, J.E., Hyde, T.M., Straub, R.E., Walsh, C.A., , Urban, A.E., Leckman, J.F., Weinberger, D.R., Vaccarino, F.M., Abyzov, A., Walsh, C.A., Park, P.J., Sestan, N., Weinberger, D., Moran, J.V., Gage, F.H., Vaccarino, F.M., Gleeson, J., Mathern, G., Courchesne, E., Roy, S., Chess, A.J., Akbarian, S., Bizzotto, S., Coulter, M., Dias, C., D'Gama, A., Ganz, J., Hill, R., Huang, A.Y., Khoshkhoo, S., Kim, S., Lee, A., Lodato, M., Maury, E.A., Miller, M., Borges-Monroy, R., Rodin, R., Zhou, Z., Bohrson, C., Chu, C., Cortes-Ciriano, I., Dou, Y., Galor, A., Gulhan, D., Kwon, M., Luquette, J., Sherman, M., Viswanadham, V., Jones, A., Rosenbluh, C., Cho, S., Langmead, B., Thorpe, J., Erwin, J., Jaffe, A., McConnell, M., Narurkar, R., Paquola, A., Shin, J., Straub, R., Abyzov, A., Bae, T., Jang, Y., Wang, Y., Molitor, C., Peters, M., Linker, S., Reed, P., Wang, M., Urban, A., Zhou, B., Zhu, X., Pattni, R., Serres Amero, A., Juan, D., Lobon, I., Marques-Bonet, T., Solis Moruno, M., Garcia Perez, R., Povolotskaya, I., Soriano, E., Antaki, D., Averbuj, D., Ball, L., Breuss, M., Yang, X., Chung, C., Emery, S.B., Flasch, D.A., Kidd, J.M., Kopera, H.C., Kwan, K.Y., Mills, R.E., Moldovan, J.B., Sun, C., Zhao, X., Zhou, W., Frisbie, T.J., Cherskov, A., Fasching, L., Jourdon, A., Pochareddy, S., Scuderi, S. Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability. (2022) Science. 377(6605):511-517. DOI: 10.1126/science.abm6222
Lecoin, L., Dempsey, B., Garancher, A., Bourane, S., Ruffault, P.L., Morin-Surun, M.P., Rocques, N., Goulding, M., Eychène, A., Pouponnot, C., Fortin, G., Champagnat, J. Mafa-dependent GABAergic activity promotes mouse neonatal apneas. (2022) Nature Communications. 13(1):3284. DOI: 10.1038/s41467-022-30825-3
Ward, S., Riley, C., Carey, E.M., Nguyen, J., Esener, S., Nimmerjahn, A., Sirbuly, D.J. Electro-optical mechanically flexible coaxial microprobes for minimally invasive interfacing with intrinsic neural circuits. (2022) Nature Communications. 13(1):3286. DOI: 10.1038/s41467-022-30275-x
Zhang, Y., Roy, D.S., Zhu, Y., Chen, Y., Aida, T., Hou, Y., Shen, C., Lea, N.E., Schroeder, M.E., Skaggs, K.M., Sullivan, H.A., Fischer, K.B., Callaway, E.M., Wickersham, I.R., Dai, J., Li, X.M., Lu, Z., Feng, G. Targeting thalamic circuits rescues motor and mood deficits in PD mice. (2022) Nature. DOI: 10.1038/s41586-022-04806-x
Chen, Y., Rosen, B.Q., Sejnowski, T.J. Dynamical differential covariance recovers directional network structure in multiscale neural systems. (2022) Proceedings of the National Academy of Sciences of the United States of America. 119(24):e2117234119. DOI: 10.1073/pnas.2117234119
Grün, S., Li, J., McNaughton, B., Petersen, C., McCormick, D., Robson, D., Buzsáki, G., Harris, K., Sejnowski, T., Mrsic-Flogel, T., Lindén, H., Roland, P.E. Emerging principles of spacetime in brains: Meeting report on spatial neurodynamics. (2022) Neuron. 110(12):1894-1898. DOI: 10.1016/j.neuron.2022.05.018
Chen, Y., Bukhari, Q., Lin, T.W., Sejnowski, T.J. Functional connectivity of fMRI using differential covariance predicts structural connectivity and behavioral reaction times. (2022) Network neuroscience. 6(2):614-633. DOI: 10.1162/netn_a_00239
Zhou, Y., Sharpee, T.O. Using Global t-SNE to Preserve Intercluster Data Structure. (2022) Neural Computation.:1-15 DOI: 10.1162/neco_a_01504
Tadokoro, T., Bravo-Hernandez, M., Agashkov, K., Kobayashi, Y., Platoshyn, O., Navarro, M., Marsala, S., Miyanohara, A., Yoshizumi, T., Shigyo, M., Krotov, V., Juhas, S., Juhasova, J., Nguyen, D., Skalnikova, H.K., Motlik, J., Studenovska, H., Proks, V., Reddy, R., Driscoll, S.P., Glenn, T.D., Kemthong, T., Malaivijitnond, S., Tomori, Z., Vanicky, I., Kakinohana, M., Pfaff, S.L., Ciacci, J., Belan, P., Marsala, M. Precision spinal gene delivery-induced functional switch in nociceptive neurons reverses neuropathic pain. (2022) Molecular Therapy. DOI: 10.1016/j.ymthe.2022.04.023
Garcia, J.W., Bartol, T.M., Sejnowski, T.J. Multiscale modeling of presynaptic dynamics from molecular to mesoscale. (2022) PLOS Computational Biology. 18(5):e1010068. DOI: 10.1371/journal.pcbi.1010068
Li, J., Pinto-Duarte, A., Zander, M., Cuoco, M.S., Lai, C.Y., Osteen, J., Fang, L., Luo, C., Lucero, J.D., Gomez-Castanon, R., Nery, J.R., Silva-Garcia, I., Pang, Y., Sejnowski, T.J., Powell, S.B., Ecker, J.R., Mukamel, E.A., Behrens, M.M. Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3. (2022) Elife. 11. DOI: 10.7554/eLife.66909
Patiño, M., Lagos, W.N., Patne, N.S., Tasic, B., Zeng, H., Callaway, E.M. Single-cell transcriptomic classification of rabies-infected cortical neurons. (2022) Proceedings of the National Academy of Sciences of the United States of America. 119(22):e2203677119. DOI: 10.1073/pnas.2203677119
Oliinyk, O.S., Baloban, M., Clark, C.L., Carey, E., Pletnev, S., Nimmerjahn, A., Verkhusha, V.V. Single-domain near-infrared protein provides a scaffold for antigen-dependent fluorescent nanobodies. (2022) Nature Methods. DOI: 10.1038/s41592-022-01467-6
Nimmerjahn, A., Hirrlinger, J. Astrocyte regulation of neural circuit function and animal behavior. (2022) Glia. DOI: 10.1002/glia.24223
Shi, Y., Evans, R.M., Gage, F.H. Oleic acid regulates hippocampal neurogenesis as a TLX ligand. (2022) Proceedings of the National Academy of Sciences of the United States of America. 119(15):e2203038119. DOI: 10.1073/pnas.2203038119
Amin, N.D., Senturk, G., Hayashi, M., Driscoll, S.P., Pfaff, S.L. Detecting microRNA-mediated gene regulatory effects in murine neuronal subpopulations. (2022) STAR Protoc. 3(1):101130. DOI: 10.1016/j.xpro.2022.101130
Cook, J.R., Li, H., Nguyen, B., Huang, H.H., Mahdavian, P., Kirchgessner, M.A., Strassmann, P., Engelhardt, M., Callaway, E.M., Jin, X. Secondary auditory cortex mediates a sensorimotor mechanism for action timing. (2022) Nature Neuroscience. 25(3):330-344. DOI: 10.1038/s41593-022-01025-5
Hirrlinger, J., Nimmerjahn, A. A perspective on astrocyte regulation of neural circuit function and animal behavior. (2022) Glia. DOI: 10.1002/glia.24168
Zhang, Z., Cisneros, E., Lee, H.Y., Vu, J.P., Chen, Q., Benadof, C.N., Whitehill, J., Rouzbehani, R., Sy, D.T., Huang, J.S., Sejnowski, T.J., Jankovic, J., Factor, S., Goetz, C.G., Barbano, R.L., Perlmutter, J.S., Jinnah, H.A., Berman, B.D., Richardson, S.P., Stebbins, G.T., Comella, C.L., Peterson, D.A. Hold that pose: capturing cervical dystonia's head deviation severity from video. (2022) Ann Clin Transl Neurol. DOI: 10.1002/acn3.51549
Budzinski, R.C., Nguyen, T.T., Đoàn, J., Mináč, J., Sejnowski, T.J., Muller, L.E. Geometry unites synchrony, chimeras, and waves in nonlinear oscillator networks. (2022) Chaos. 32(3):031104. DOI: 10.1063/5.0078791
Hetzer, M.W., Bersini, S. Beyond Static Pipes: Mechanisms and In Vitro Models of Vascular Aging. (2022) Cold Spring Harb Perspect Med. DOI: 10.1101/cshperspect.a041180
Abdelfattah, A.S., Ahuja, S., Akkin, T., Allu, S.R., Brake, J., Boas, D.A., Buckley, E.M., Campbell, R.E., Chen, A.I., Cheng, X., Čižmár, T., Costantini, I., De Vittorio, M., Devor, A., Doran, P.R., El Khatib, M., Emiliani, V., Fomin-Thunemann, N., Fainman, Y., Fernandez-Alfonso, T., Ferri, C.G.L., Gilad, A., Han, X., Harris, A., Hillman, E.M.C., Hochgeschwender, U., Holt, M.G., Ji, N., Kılıç, K., Lake, E.M.R., Li, L., Li, T., Mächler, P., Miller, E.W., Mesquita, R.C., Nadella, K.M.N.S., Nägerl, U.V., Nasu, Y., Nimmerjahn, A., Ondráčková, P., Pavone, F.S., Perez Campos, C., Peterka, D.S., Pisano, F., Pisanello, F., Puppo, F., Sabatini, B.L., Sadegh, S., Sakadzic, S., Shoham, S., Shroff, S.N., Silver, R.A., Sims, R.R., Smith, S.L., Srinivasan, V.J., Thunemann, M., Tian, L., Tian, L., Troxler, T., Valera, A., Vaziri, A., Vinogradov, S.A., Vitale, F., Wang, L.V., Uhlířová, H., Xu, C., Yang, C., Yang, M.H., Yellen, G., Yizhar, O., Zhao, Y. Neurophotonic tools for microscopic measurements and manipulation: status report. (2022) Neurophotonics. 9(Suppl 1):013001. DOI: 10.1117/1.NPh.9.S1.013001
Taiber, S., Gozlan, O., Cohen, R., Andrade, L.R., Gregory, E.F., Starr, D.A., Moran, Y., Hipp, R., Kelley, M.W., Manor, U., Sprinzak, D., Avraham, K.B. A Nesprin-4/kinesin-1 cargo model for nuclear positioning in cochlear outer hair cells. (2022) Front Cell Dev Biol. 10:974168. DOI: 10.3389/fcell.2022.974168
