2021 PUBLICATIONS
Chassefeyre, R., Chaiamarit, T., Verhelle, A., Novak, S.W., Andrade, L.R., Leitão, A.D.G., Manor, U., Encalada, S.E. Endosomal sorting drives the formation of axonal prion protein endoggresomes. (2021) Science Advances. 7(52):eabg3693. DOI: 10.1126/sciadv.abg3693
Liu, J., Hetzer, M.W. Nuclear pore complex maintenance and implications for age-related diseases. (2021) Trends in Cell Biology. DOI: 10.1016/j.tcb.2021.10.001
Gage, F.H. Adult neurogenesis in neurological diseases. [Pubmed] (2021) Science. 374(6571):1049-1050. DOI: 10.1126/science.abm7468
Heard, K.J., Shokhirev, M.N., Becronis, C., Fredlender, C., Zahid, N., Le, A.T., Ji, Y., Skime, M., Nelson, T., Hall-Flavin, D., Weinshilboum, R., Gage, F.H., Vadodaria, K.C. Chronic cortisol differentially impacts stem cell-derived astrocytes from major depressive disorder patients. (2021) Transl Psychiatry. 11(1):608. DOI: 10.1038/s41398-021-01733-9
Wagner, M., Bartol, T.M., Sejnowski, T.J., Cauwenberghs, G. Markov Chain Abstractions of Electrochemical Reaction-Diffusion in Synaptic Transmission for Neuromorphic Computing. (2021) Frontiers in Neuroscience. 15:698635. DOI: 10.3389/fnins.2021.698635
Mendelsohn, R., Garcia, G.C., Bartol, T.M., Lee, C.T., Khandelwal, P., Liu, E., Spencer, D.J., Husar, A., Bushong, E.A., Phan, S., Perkins, G., Ellisman, M.H., Skupin, A., Sejnowski, T.J., Rangamani, P. Morphological principles of neuronal mitochondria. (2021) Journal of Comparative Neurology. DOI: 10.1002/cne.25254
Liu, H., Zhou, J., Tian, W., Luo, C., Bartlett, A., Aldridge, A., Lucero, J., Osteen, J.K., Nery, J.R., Chen, H., Rivkin, A., Castanon, R.G., Clock, B., Li, Y.E., Hou, X., Poirion, O.B., Preissl, S., Pinto-Duarte, A., O'Connor, C., Boggeman, L., Fitzpatrick, C., Nunn, M., Mukamel, E.A., Zhang, Z., Callaway, E.M., Ren, B., Dixon, J.R., Behrens, M.M., Ecker, J.R. DNA methylation atlas of the mouse brain at single-cell resolution. (2021) Nature. 598(7879):120-128. DOI: 10.1038/s41586-020-03182-8
Zhang, Z., Zhou, J., Tan, P., Pang, Y., Rivkin, A.C., Kirchgessner, M.A., Williams, E., Lee, C.T., Liu, H., Franklin, A.D., Miyazaki, P.A., Bartlett, A., Aldridge, A.I., Vu, M., Boggeman, L., Fitzpatrick, C., Nery, J.R., Castanon, R.G., Rashid, M., Jacobs, M.W., Ito-Cole, T., O'Connor, C., Pinto-Duartec, A., Dominguez, B., Smith, J.B., Niu, S.Y., Lee, K.F., Jin, X., Mukamel, E.A., Behrens, M.M., Ecker, J.R., Callaway, E.M. Epigenomic diversity of cortical projection neurons in the mouse brain. (2021) Nature. 598(7879):167-173. DOI: 10.1038/s41586-021-03223-w
Davis, Z.W., Benigno, G.B., Fletterman, C., Desbordes, T., Steward, C., Sejnowski, T.J., Reynolds, J.H., Muller, L. Spontaneous traveling waves naturally emerge from horizontal fiber time delays and travel through locally asynchronous-irregular states. (2021) Nature Communications. 12(1):6057. DOI: 10.1038/s41467-021-26175-1
Ma, Z., Lytle, N.K., Chen, B., Jyotsana, N., Novak, S.W., Cho, C.J., Caplan, L., Ben-Levy, O., Neininger, A.C., Burnette, D.T., Trinh, V.Q., Tan, M.C.B., Patterson, E.A., Arrojo E Drigo, R., Giraddi, R.R., Ramos, C., Means, A.L., Matsumoto, I., Manor, U., Mills, J.C., Goldenring, J.R., Lau, K.S., Wahl, G.M., DelGiorno, K.E. Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injury. (2021) Gastroenterology. DOI: 10.1053/j.gastro.2021.10.027
Li, Y., Kim, R., Sejnowski, T.J. Learning the Synaptic and Intrinsic Membrane Dynamics Underlying Working Memory in Spiking Neural Network Models. (2021) Neural Computation.:1-24 DOI: 10.1162/neco_a_01409
Krishna, S., Arrojo E Drigo, R., Capitanio, J.S., Ramachandra, R., Ellisman, M., Hetzer, M.W. Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain. (2021) Developmental Cell. DOI: 10.1016/j.devcel.2021.10.008
Lainscsek, C., Cash, S.S., Sejnowski, T.J., Kurths, J. Dynamical ergodicity DDA reveals causal structure in time series. (2021) Chaos. 31(10):103108. DOI: 10.1063/5.0063724
Kirchgessner, M.A., Franklin, A.D., Callaway, E.M. Distinct "driving" versus "modulatory" influences of different visual corticothalamic pathways. (2021) Current Biology. DOI: 10.1016/j.cub.2021.09.025
Gorbunova, V., Seluanov, A., Mita, P., McKerrow, W., Fenyö, D., Boeke, J.D., Linker, S.B., Gage, F.H., Kreiling, J.A., Petrashen, A.P., Woodham, T.A., Taylor, J.R., Helfand, S.L., Sedivy, J.M. The role of retrotransposable elements in ageing and age-associated diseases. https://rdcu.be/ct1i3 Full-text provided by the Springer Nature SharedIt content-sharing initiative [Pubmed] (2021) Nature. 596(7870):43-53. DOI: 10.1038/s41586-021-03542-y
Shadel, G.S., Adams, P.D., Berggren, W.T., Diedrich, J.K., Diffenderfer, K.E., Gage, F.H., Hah, N., Hansen, M., Hetzer, M.W., Molina, A.J.A., Manor, U., Marek, K., O'Keefe, D.D., Pinto, A.F.M., Sacco, A., Sharpee, T.O., Shokriev, M.N., Zambetti, S. The San Diego Nathan Shock Center: tackling the heterogeneity of aging. (2021) Geroscience. DOI: 10.1007/s11357-021-00426-x
Amin, N.D., Senturk, G., Costaguta, G., Driscoll, S., O'Leary, B., Bonanomi, D., Pfaff, S.L. A hidden threshold in motor neuron gene networks revealed by modulation of miR-218 dose. (2021) Neuron. DOI: 10.1016/j.neuron.2021.07.028
Hayes, T.L., Krishnan, G.P., Bazhenov, M., Siegelmann, H.T., Sejnowski, T.J., Kanan, C. Replay in Deep Learning: Current Approaches and Missing Biological Elements. (2021) Neural Computation.:1-44 DOI: 10.1162/neco_a_01433
Johnston, S., Parylak, S., Kim, S., Mac, N., Lim, C., Gallina, I., Bloyd, C., Newberry, A., Saavedra, C.D., Novak, O., Goncalves, J.T., Gage, F.H., Shtrahman, M. AAV ablates neurogenesis in the adult murine hippocampus. (2021) Elife. 10. DOI: 10.7554/eLife.59291
Nakahira, Y., Liu, Q., Sejnowski, T.J., Doyle, J.C. Diversity-enabled sweet spots in layered architectures and speed-accuracy trade-offs in sensorimotor control. (2021) Proceedings of the National Academy of Sciences of the United States of America. 118(22). DOI: 10.1073/pnas.1916367118
Tan, K., Kim, M.E., Song, H.W., Skarbrevik, D., Babajanian, E., Bedrosian, T.A., Gage, F.H., Wilkinson, M.F. The Rhox gene cluster suppresses germline LINE1 transposition. (2021) Proceedings of the National Academy of Sciences of the United States of America. 118(23). DOI: 10.1073/pnas.2024785118
Faulkner, R.L., Wall, N.R., Callaway, E.M., Cline, H.T. Application of Recombinant Rabies Virus to Xenopus Tadpole Brain. (2021) eNeuro. DOI: 10.1523/ENEURO.0477-20.2021
Schafer, S.T., Gage, F.H. To eat, or not to eat, that is the question: Neural stem cells escape phagocytosis in autism with macrocephaly. (2021) Proceedings of the National Academy of Sciences of the United States of America. 118(19). DOI: 10.1073/pnas.2104888118
Compans, B., Camus, C., Kallergi, E., Sposini, S., Martineau, M., Butler, C., Kechkar, A., Klaassen, R.V., Retailleau, N., Sejnowski, T.J., Smit, A.B., Sibarita, J.B., Bartol, T.M., Perrais, D., Nikoletopoulou, V., Choquet, D., Hosy, E. NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95. (2021) Nature Communications. 12(1):2849. DOI: 10.1038/s41467-021-23133-9
Dias, G.P., Murphy, T., Stangl, D., Ahmet, S., Morisse, B., Nix, A., Aimone, L.J., Aimone, J.B., Kuro-O, M., Gage, F.H., Thuret, S. Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho. (2021) Molecular Psychiatry. DOI: 10.1038/s41380-021-01102-4
Hsu, W.M., Kastner, D.B., Baccus, S.A., Sharpee, T.O. How inhibitory neurons increase information transmission under threshold modulation. (2021) Cell Reports. 35(8):109158. DOI: 10.1016/j.celrep.2021.109158
Reid, D.A., Reed, P.J., Schlachetzki, J.C.M., Nitulescu, I.I., Chou, G., Tsui, Chandran, S., Jones, J.R., Lu, A.T., McClain, C.A., Ooi, J.H., Wang, T.W., Lana, Linker, S.B., Ricciardulli, A.S., Lau, S., Schafer, S., Horvath, S., Dixon, J.R., Hah, N., Glass, C.K., Gage, F.H. Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons. (2021) Science. 372(6537):91-94. DOI: 10.1126/science.abb9032
Huang, Y., Happonen, K.E., Burrola, P.G., O'Connor, C., Hah, N., Huang, L., Nimmerjahn, A., Lemke, G. Microglia use TAM receptors to detect and engulf amyloid β plaques. (2021) Nature Immunology. DOI: 10.1038/s41590-021-00913-5
Osseward, P.J., Amin, N.D., Moore, J.D., Temple, B.A., Barriga, B.K., Bachmann, L.C., Beltran, F., Gullo, M., Clark, R.C., Driscoll, S.P., Pfaff, S.L., Hayashi, M. Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets. (2021) Science. 372(6540):385-393. DOI: 10.1126/science.abe0690
Mertens, J., Herdy, J.R., Traxler, L., Schafer, S.T., Schlachetzki, J.C.M., Böhnke, L., Reid, D.A., Lee, H., Zangwill, D., Fernandes, D.P., Agarwal, R.K., Lucciola, R., Zhou-Yang, L., Karbacher, L., Edenhofer, F., Stern, S., Horvath, S., Paquola, A.C.M., Glass, C.K., Yuan, S.H., Ku, M., Szücs, A., Goldstein, L.S.B., Galasko, D., Gage, F.H. Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients. (2021) Cell Stem Cell. DOI: 10.1016/j.stem.2021.04.004
Schafer, S.T., Gage, F.H. The When and Where: Molecular and Cellular Convergence in Autism. (2021) Biological Psychiatry. 89(5):419-420. DOI: 10.1016/j.biopsych.2020.12.016
Mishra, H.K., Ying, N.M., Luis, A., Wei, H., Nguyen, M., Nakhla, T., Vandenburgh, S., Alda, M., Berrettini, W.H., Brennand, K.J., Calabrese, J.R., Coryell, W.H., Frye, M.A., Gage, F.H., Gershon, E.S., McInnis, M.G., Nievergelt, C.M., Nurnberger, J.I., Shilling, P.D., Oedegaard, K.J., Zandi, P.P., , Kelsoe, J.R., Welsh, D.K., McCarthy, M.J. Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response: preliminary studies. (2021) Molecular Psychiatry. DOI: 10.1038/s41380-021-01048-7
Fang, L., Monroe, F., Novak, S.W., Kirk, L., Schiavon, C.R., Yu, S.B., Zhang, T., Wu, M., Kastner, K., Latif, A.A., Lin, Z., Shaw, A., Kubota, Y., Mendenhall, J., Zhang, Z., Pekkurnaz, G., Harris, K., Howard, J., Manor, U. Deep learning-based point-scanning super-resolution imaging. (2021) Nature Methods. DOI: 10.1038/s41592-021-01080-z
Zhou, Y., Sharpee, T.O. Hyperbolic geometry of gene expression. (2021) iScience. 24(3):102225. DOI: 10.1016/j.isci.2021.102225
Nakatsuka, N., Heard, K.J., Faillétaz, A., Momotenko, D., Vörös, J., Gage, F.H., Vadodaria, K.C. Sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes. (2021) Molecular Psychiatry. DOI: 10.1038/s41380-021-01066-5
Lei, Y., Zhang, J., Schiavon, C.R., He, M., Chen, L., Shen, H., Zhang, Y., Yin, Q., Cho, Y., Andrade, L., Shadel, G.S., Hepokoski, M., Lei, T., Wang, H., Zhang, J., Yuan, J.X., Malhotra, A., Manor, U., Wang, S., Yuan, Z.Y., Shyy, J.Y. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2. (2021) Circulation research. DOI: 10.1161/CIRCRESAHA.121.318902
Bedrosian, T.A., Houtman, J., Eguiguren, J.S., Ghassemzadeh, S., Rund, N., Novaresi, N.M., Hu, L., Parylak, S.L., Denli, A.M., Randolph-Moore, L., Namba, T., Gage, F.H., Toda, T. Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis. (2021) EMBO Journal. 40(3):e105819. DOI: 10.15252/embj.2020105819
Fukuda, S., Varshney, A., Fowler, B.J., Wang, S.B., Narendran, S., Ambati, K., Yasuma, T., Magagnoli, J., Leung, H., Hirahara, S., Nagasaka, Y., Yasuma, R., Apicella, I., Pereira, F., Makin, R.D., Magner, E., Liu, X., Sun, J., Wang, M., Baker, K., Marion, K.M., Huang, X., Baghdasaryan, E., Ambati, M., Ambati, V.L., Pandey, A., Pandya, L., Cummings, T., Banerjee, D., Huang, P., Yerramothu, P., Tolstonog, G.V., Held, U., Erwin, J.A., Paquola, A.C.M., Herdy, J.R., Ogura, Y., Terasaki, H., Oshika, T., Darwish, S., Singh, R.K., Mozaffari, S., Bhattarai, D., Kim, K.B., Hardin, J.W., Bennett, C.L., Hinton, D.R., Hanson, T.E., Röver, C., Parang, K., Kerur, N., Liu, J., Werner, B.C., Sutton, S.S., Sadda, S.R., Schumann, G.G., Gelfand, B.D., Gage, F.H., Ambati, J. Cytoplasmic synthesis of endogenous complementary DNA via reverse transcription and implications in age-related macular degeneration. (2021) Proceedings of the National Academy of Sciences of the United States of America. 118(6). DOI: 10.1073/pnas.2022751118
Schiavon, C.R., Shadel, G.S., Manor, U. Impaired Mitochondrial Mobility in Charcot-Marie-Tooth Disease. (2021) Front Cell Dev Biol. 9:624823. DOI: 10.3389/fcell.2021.624823
Singh, N., Bartol, T., Levine, H., Sejnowski, T., Nadkarni, S. Presynaptic endoplasmic reticulum regulates short-term plasticity in hippocampal synapses. (2021) Communications Biology. 4(1):241. DOI: 10.1038/s42003-021-01761-7
Vadodaria, K.C., Mendes, A.P.D., Mei, A., Racha, V., Erikson, G., Shokhirev, M.N., Oefner, R., Heard, K.J., McCarthy, M.J., Eyler, L., Kelsoe, J.R., Santos, R., Marchetto, M.C., Gage, F.H. Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes. (2021) Stem Cell Reports. DOI: 10.1016/j.stemcr.2021.02.004
Santos, R., Linker, S.B., Stern, S., Mendes, A.P.D., Shokhirev, M.N., Erikson, G., Randolph-Moore, L., Racha, V., Kim, Y., Kelsoe, J.R., Bang, A.G., Alda, M., Marchetto, M.C., Gage, F.H. Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients. (2021) Molecular Psychiatry. DOI: 10.1038/s41380-020-00981-3
Lehman, B.J., Lopez-Diaz, F.J., Santisakultarm, T.P., Fang, L., Shokhirev, M.N., Diffenderfer, K.E., Manor, U., Emerson, B.M. Dynamic regulation of CTCF stability and sub-nuclear localization in response to stress. (2021) PLOS Genetics. 17(1):e1009277. DOI: 10.1371/journal.pgen.1009277
Zholudeva, L.V., Abraira, V.E., Satkunendrarajah, K., McDevitt, T.C., Goulding, M.D., Magnuson, D.S.K., Lane, M.A. Spinal Interneurons as Gatekeepers to Neuroplasticity after Injury or Disease. (2021) Journal of Neuroscience. DOI: 10.1523/JNEUROSCI.1654-20.2020
Trujillo, C.A., Adams, J.W., Negraes, P.D., Carromeu, C., Tejwani, L., Acab, A., Tsuda, B., Thomas, C.A., Sodhi, N., Fichter, K.M., Romero, S., Zanella, F., Sejnowski, T.J., Ulrich, H., Muotri, A.R. Pharmacological reversal of synaptic and network pathology in human MECP2-KO neurons and cortical organoids. (2021) EMBO Molecular Medicine. 13(1):e12523. DOI: 10.15252/emmm.202012523
