Sreekanth Chalasani

Associate Professor

Molecular Neurobiology Laboratory

Salk Institute for Biological Studies - Publications

List of Publications


Hale L.A., Lee E.S., Pantazis A.K., Chronis N., Chalasani, S.H. (2017). Altered Sensory Code Drives Juvenile-to-Adult Behavioral Maturation in Caenorhabditis elegans. eNeuro. 2017 Jan 5;3(6). pii: ENEURO.0175-16.2016. doi: 10.1523/ENEURO.0175-16.2016.
PubMed

Leinwand, S.G., Yang, C.J., Bazopoulou, D., Chronis, N., Srinivasan, J., & Chalasani, S.H. (2015). Circuit mechanisms encoding odors and driving aging-associated behavioral declines in Caenorhabditis elegans. eLife, 4, e10181. http://doi.org/10.7554/eLife.10181
PubMed

Ibsen S., Tong A., Schutt C, Esener S., Chalasani, S.H. Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans. Nat Commun. 2015 Sep 15;6:8264. doi: 10.1038/ncomms9264.
PubMed

Calhoun, A.J., Pokala, N., Tong, A., Fitzpatrick, J.A., Sharpee, T.O., Chalasani, S.H. Neural Mechanisms for Evaluating Environmental Variability in Caenorhabditis elegans. Neuron. 2015 Apr 8. pii: S0896-6273(15)00250-0. doi: 10.1016/j.neuron.2015.03.026.
PubMed

Erickstad, M., Hale, L.A., Chalasani, S.H., Groisman A. A microfluidic system for studying the behavior of zebrafish larvae under acute hypoxia. Lab Chip. 2015 Jan 22;15(3):857-66. doi: 10.1039/c4lc00717d.
PubMed

Calhoun, A.J., Chalasani, S.H., Sharpee, T.O. Maximally informative foraging by Caenorhabditis elegans. Elife. 2014 Dec 9;3. doi: 10.7554/eLife.04220.
PubMed

Leinwand, S.G., Chalasani, S.H., From genes to circuits and behaviors: Neuropeptides expand the coding potential of the nervous system. Worm. 2014 Jan 31;3:e27730. doi: 10.4161/worm.27730. eCollection 2014.
PubMed

Sharpee T.O., Calhoun A.J., Chalasani S.H. Information theory of adaptation in neurons, behavior, and mood. Curr Opin Neurobiol. 2014 Apr; 25C:47-53. DOI: 10.1016/j.conb.2013.11.007. Epub 2013 Dec 14. Review.
PubMed

Lau H.E. and Chalasani, S.H. (2014) Divergent and convergent roles for insulin-like peptides in the worm, fly and mammalian nervous systems. Invert. Neurosci. PMID: 24395463.
PubMed

Joens, M.S., Huynh, C., Kasuboski, J.M., Ferranti, D., Sigal, Y.J., Zeitvogel, F., Obst, M., Burkhardt, C.J., Curran, K.P., Chalasani, S.H., Stern, L.A., Goetze, B., Fitzpatrick, J.A. (2013) Helium Ion Microscopy (HIM) for the imaging of biological samples at sub-nanometer resolution. Sci. Rep.DOI: 10.1038/srep03514.
PubMed

Leinwand, S.G. and Chalasani, S.H. (2013). Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans. Nature Neuroscience. DOI: 10.1038/nn.3511.
PubMed

Curran, K.P. and Chalasani, S.H. (2012). Serotonin circuits and anxiety: what can invertebrates teach us? Invert Neurosci. DOI 10.1007/s10158-012-0140-y.
PubMed

Leinwand, S.G. and Chalasani, S.H. Olfactory networks: from sensation to perception. Curr. Opin in Genet. & Dev.21, 1-6 (2011).
PubMed

Postdoctoral Research

Chalasani, S.H., Kato, S., Albrecht, D.R., Nakagawa, T., Abbot, L.F., and Bargmann, C.I. Neuropeptide feedback modifies odor-evoked dynamics in C.elegans olfactory neurons. Nature Neuroscience 13,615-621 (2010).
PubMed

Tian, L., Hires, S.A., Mao, T., Huber, D., Chiappe, M.E., Chalasani, S.H., Petreanu, L., Akerboom, J., Schreiter, E.R., Bargmann, C.I., Jayaraman, V., Svoboda, K., and Looger, L.L. Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. Nature Methods 6, 875-881 (2009).
PubMed

Macosko, E.Z., Pokala, N., Feinberg, E.H., Chalasani, S.H., Butcher, R.A., Clardy, J., and Bargmann, C.I. A hub-and-spoke circuit drives pheromone attraction and social behaviour in C.elegans. Nature 458, 1171-1175 (2009).
PubMed

Tsunozaki, M., Chalasani, S.H., and Bargmann, C.I. A behavioral switch: cGMP and PKC signaling in olfactory neurons reverses odor preference in C. elegans. Neuron 59, 959-971 (2008).
PubMed

Chalasani, S.H., Chronis, N., Tsunozaki, M., Gray, J.M., Ramot, D., Goodman, M.B., and Bargmann, C.I. Dissecting a neural circuit for olfactory behaviour in Caenorhabditis elegans. Nature 450, 63-70 (2007).
PubMed

Ph.D. Research

Chalasani, S.H.*, Sabol, A.*, Xu, H., Gyda, M.A., Rasband, K., Granato, M., Chien, C.-B., and Raper, J.A. Stromal cell-derived factor (SDF-1) antagonizes Slit/Robo signaling in vivo. * Equal contribution. J. Neuroscience 27, 973-980 (2007).
PubMed

Kreibich, T.A.*, Chalasani, S.H.*, and Raper, J.A. The neurotransmitter glutamate reduces the axonal responsiveness to multiple repellents through the activation of mGluR1. * Equal contribution. J. Neuroscience 24, 7085-7095 (2004).
PubMed

Vatamaniuk O.K., Mari S., Lang A., Chalasani S.H., Demkiv L.O., Rea P.A. Phytochelatin synthase, a dipeptidyltransferase that undergoes multisite acylation with gamma-glutamylcysteine during catalysis: stoichiometric and site-directed mutagenic analysis of arabidopsis thaliana PCS1-catalyzed phytochelatin synthesis. J Biol Chem. 2004 May 21;279(21):22449-60. Epub 2004 Mar 5.
PubMed

Chalasani, S.H., Baribaud, F., Coughlan, C.M., Sunshine, M.J., Lee, V.M.Y., Doms, R.W., Littman, D.R., and Raper, J.A. The chemokine Stromal cell-Derived Factor-1 promotes the survival of embryonic retinal ganglion cells. J. Neuroscience 23, 4601-4612 (2003).
PubMed

Chalasani, S.H., Sabelko, K.A., Sunshine, M.J., Littman, D.R., and Raper, J.A. The chemokine, SDF-1, reduces the effectiveness of multiple axonal repellents and is required for normal pathfinding. J. Neuroscience 23, 1360-1371 (2003).
PubMed

Education

BS, Osmania University, India
PhD, University of Pennsylvania
Post Doctoral Researcher, Rockefeller University (lab moved from University of California San Francisco)


Awards & Honors

  • 2010 Searle Scholar
  • 2010 Basil O'Connor Award from the March of Dimes