Sreekanth Chalasani

Associate Professor

Molecular Neurobiology Laboratory

Salk Institute for Biological Studies - Publications

all Publications


Liu, Z., Kariya, M.J., Chute, C.D., Pribadi, A.K., Leinwand, S.G., Tong, A., Curran, K.P., Bose, N., Schroeder, F.C., Srinivasan, J., Chalasani, S.H. Predator-secreted sulfolipids induce defensive responses in C. elegans. (2018) Nature Communications. 9(1):1128. DOI: 10.1038/s41467-018-03333-6

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Hale, L.A., Lee, E.S., Pantazis, A.K., Chronis, N., Chalasani, S.H. Altered Sensory Code Drives Juvenile-to-Adult Behavioral Maturation in Caenorhabditis elegans. (2017) eNeuro. 3(6). DOI: 10.1523/ENEURO.0175-16.2016

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Leinwand, S.G., Yang, C.J., Bazopoulou, D., Chronis, N., Srinivasan, J., Chalasani, S.H. Circuit mechanisms encoding odors and driving aging-associated behavioral declines in Caenorhabditis elegans. (2015) Elife. 4:e10181. DOI: 10.7554/eLife.10181

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Ibsen, S., Tong, A., Schutt, C., Esener, S., Chalasani, S.H. Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans. (2015) Nature Communications. 6:8264. DOI: 10.1038/ncomms9264

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Calhoun, A.J., Tong, A., Pokala, N., Fitzpatrick, J.A., Sharpee, T.O., Chalasani, S.H. Neural Mechanisms for Evaluating Environmental Variability in Caenorhabditis elegans. (2015) Neuron. 86(2):428-41. DOI: 10.1016/j.neuron.2015.03.026

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Erickstad, M., Hale, L.A., Chalasani, S.H., Groisman, A. A microfluidic system for studying the behavior of zebrafish larvae under acute hypoxia. (2015) Lab Chip. 15(3):857-66. DOI: 10.1039/c4lc00717d

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Calhoun, A.J., Chalasani, S.H., Sharpee, T.O. Maximally informative foraging by Caenorhabditis elegans. (2014) Elife. 3. DOI: 10.7554/eLife.04220

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Lau, H.E., Chalasani, S.H. Divergent and convergent roles for insulin-like peptides in the worm, fly and mammalian nervous systems. (2014) Invertebrate Neuroscience. 14(2):71-8. DOI: 10.1007/s10158-013-0166-9

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Sharpee, T.O., Calhoun, A.J., Chalasani, S.H. Information theory of adaptation in neurons, behavior, and mood. (2014) Current Opinion in Neurobiology. 25:47-53. DOI: 10.1016/j.conb.2013.11.007

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Leinwand, S.G., Chalasani, S.H. From genes to circuits and behaviors: Neuropeptides expand the coding potential of the nervous system. (2014) Worm. 3:e27730. DOI: 10.4161/worm.27730

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Joens, M.S., Huynh, C., Kasuboski, J.M., Ferranti, D., Sigal, Y.J., Zeitvogel, F., Obst, M., Burkhardt, C.J., Curran, K.P., Chalasani, S.H., Stern, L.A., Goetze, B., Fitzpatrick, J.A. Helium Ion Microscopy (HIM) for the imaging of biological samples at sub-nanometer resolution. (2013) Scientific Reports. 3:3514. DOI: 10.1038/srep03514

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Leinwand, S.G., Chalasani, S.H. Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans. (2013) Nature Neuroscience. 16(10):1461-7. DOI: 10.1038/nn.3511

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Curran, K.P., Chalasani, S.H. Serotonin circuits and anxiety: what can invertebrates teach us? (2012) Invertebrate Neuroscience. 12(2):81-92. DOI: 10.1007/s10158-012-0140-y

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Leinwand, S.G., Chalasani, S.H. Olfactory networks: from sensation to perception. (2011) Current Opinion in Genetics & Development. 21(6):806-11. DOI: 10.1016/j.gde.2011.07.006

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Chalasani, S.H., Kato, S., Albrecht, D.R., Nakagawa, T., Abbott, L.F., Bargmann, C.I. Neuropeptide feedback modifies odor-evoked dynamics in Caenorhabditis elegans olfactory neurons. (2010) Nature Neuroscience. 13(5):615-21. DOI: 10.1038/nn.2526

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Tian, L., Hires, S.A., Mao, T., Huber, D., Chiappe, M.E., Chalasani, S.H., Petreanu, L., Akerboom, J., McKinney, S.A., Schreiter, E.R., Bargmann, C.I., Jayaraman, V., Svoboda, K., Looger, L.L. Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. (2009) Nature Methods. 6(12):875-81. DOI: 10.1038/nmeth.1398

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Macosko, E.Z., Pokala, N., Feinberg, E.H., Chalasani, S.H., Butcher, R.A., Clardy, J., Bargmann, C.I. A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans. (2009) Nature. 458(7242):1171-5. DOI: 10.1038/nature07886

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Tsunozaki, M., Chalasani, S.H., Bargmann, C.I. A behavioral switch: cGMP and PKC signaling in olfactory neurons reverses odor preference in C. elegans. (2008) Neuron. 59(6):959-71. DOI: 10.1016/j.neuron.2008.07.038

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Chalasani, S.H., Chronis, N., Tsunozaki, M., Gray, J.M., Ramot, D., Goodman, M.B., Bargmann, C.I. Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans. (2007) Nature. 450(7166):63-70. DOI: 10.1038/nature06292

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Chalasani, S.H., Feinberg, E.H., Hilliard, M.A. Global 'worming'. (2007) Genome Biology. 8(9):314. DOI: 10.1186/gb-2007-8-9-314


Chalasani, S.H., Sabol, A., Xu, H., Gyda, M.A., Rasband, K., Granato, M., Chien, C.B., Raper, J.A. Stromal cell-derived factor-1 antagonizes slit/robo signaling in vivo. (2007) Journal of Neuroscience. 27(5):973-80. DOI: 10.1523/JNEUROSCI.4132-06.2007

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Kreibich, T.A., Chalasani, S.H., Raper, J.A. The neurotransmitter glutamate reduces axonal responsiveness to multiple repellents through the activation of metabotropic glutamate receptor 1. (2004) Journal of Neuroscience. 24(32):7085-95. DOI: 10.1523/JNEUROSCI.0349-04.2004

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Vatamaniuk, O.K., Mari, S., Lang, A., Chalasani, S., Demkiv, L.O., Rea, P.A. Phytochelatin synthase, a dipeptidyltransferase that undergoes multisite acylation with gamma-glutamylcysteine during catalysis: stoichiometric and site-directed mutagenic analysis of arabidopsis thal (2004) Journal of Biological Chemistry. 279(21):22449-60. DOI: 10.1074/jbc.M313142200

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Chalasani, S.H., Baribaud, F., Coughlan, C.M., Sunshine, M.J., Lee, V.M., Doms, R.W., Littman, D.R., Raper, J.A. The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells. (2003) Journal of Neuroscience. 23(11):4601-12.

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Chalasani, S.H., Sabelko, K.A., Sunshine, M.J., Littman, D.R., Raper, J.A. A chemokine, SDF-1, reduces the effectiveness of multiple axonal repellents and is required for normal axon pathfinding. (2003) Journal of Neuroscience. 23(4):1360-71.

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Education

BS, Osmania University, India
PhD, University of Pennsylvania
Post Doctoral Researcher, Rockefeller University (lab moved from University of California San Francisco)


Affiliations


Awards & Honors

  • 2010 Searle Scholar
  • 2010 Basil O'Connor Award from the March of Dimes