Sreekanth Chalasani

Associate Professor

Molecular Neurobiology Laboratory

Salk Institute for Biological Studies - Videos


Worms have teenage ambivalence, too

Salk Institute scientists studying roundworms suggest that, in both worms and humans, adolescent brains mature to stable adult brains by changing which brain cells they use to generate behavior. Teen worm brains drive wishy-washy behavior that allows them to stay flexible in an uncertain world, while adult worm brains drive efficient behavior. The discovery provides insight into the underlying drivers of neurological development that could help better understand the human brain and disease. Read More »

Brain Circuit Shows How Dopamine Controls Animal Behavior

Salk scientists discover a learning circuit in worms that gives clues to human behavior.

If you had 10 chances to roll a die, would you rather be guaranteed to receive $5 for every roll ($50 total) or take the risk of winning $100 if you only roll a six?

Most animals, from roundworms to humans, prefer the more predictable situation when it comes to securing resources for survival, such as food. Now, Salk scientists have discovered the basis for how animals balance learning and risk-taking behavior to get to a more predictable environment. The research reveals new details on the function of two chemical signals critical to human behavior: dopamine–responsible for reward and risk-taking–and CREB–needed for learning.
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BS, Osmania University, India
PhD, University of Pennsylvania
Post Doctoral Researcher, Rockefeller University (lab moved from University of California San Francisco)

Awards & Honors

  • 2010 Searle Scholar
  • 2010 Basil O'Connor Award from the March of Dimes