Pamela Maher, PhD

Research Professor

Cellular Neurobiology Laboratory

Pamela Maher
Salk Institute for Biological Studies - Publications

all Publications


Liang, Z., Soriano-Castell, D., Kepchia, D., Duggan, B.M., Currais, A., Schubert, D., Maher, P. Corrigendum to "Cannabinol inhibits oxytosis/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors" [Free Radic. Biol. Med. 180 (2020 Feb 20) 33-51]. (2022) Free Radical Biology & Medicine. 184:16. DOI: 10.1016/j.freeradbiomed.2022.03.022


Currais, A., Kepchia, D., Liang, Z., Maher, P. The Role of AMP-activated Protein Kinase (AMPK) in Oxytosis/Ferroptosis: Protector or Potentiator? (2022) Antioxid Redox Signal. DOI: 10.1089/ars.2022.0013

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Liang, Z., Soriano-Castell, D., Kepchia, D., Duggan, B.M., Currais, A., Schubert, D., Maher, P. Cannabinol inhibits oxytosis/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors. (2022) Free Radical Biology & Medicine. DOI: 10.1016/j.freeradbiomed.2022.01.001

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Kepchia, D., Huang, L., Currais, A., Liang, Z., Fischer, W., Maher, P. The Alzheimer's disease drug candidate J147 decreases blood plasma fatty acid levels via modulation of AMPK/ACC1 signaling in the liver. (2022) Biomed Pharmacother. 147:112648. DOI: 10.1016/j.biopha.2022.112648

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Soriano-Castell, D., Liang, Z., Maher, P., Currais, A. Profiling the chemical nature of anti-oxytotic/ferroptotic compounds with phenotypic screening. (2021) Free Radical Biology & Medicine.:313-325 DOI: 10.1016/j.freeradbiomed.2021.11.003

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Soriano-Castell, D., Currais, A., Maher, P. Defining a Pharmacological Inhibitor Fingerprint for Oxytosis/Ferroptosis. (2021) Free Radical Biology & Medicine. DOI: 10.1016/j.freeradbiomed.2021.05.023

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Soriano-Castell, D., Liang, Z., Maher, P., Currais, A. The search for anti-oxytotic/ferroptotic compounds in the plant world. (2021) Br J Pharmacol. DOI: 10.1111/bph.15517

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Kepchia, D., Currais, A., Dargusch, R., Finley, K., Schubert, D., Maher, P. Geroprotective effects of Alzheimer's disease drug candidates. (2021) Aging. 13. DOI: 10.18632/aging.202631

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Maher, P. Preventing and Treating Neurological Disorders with the Flavonol Fisetin. (2021) Brain Plast. 6(2):155-166. DOI: 10.3233/BPL-200104

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Maher, P. Investigations into the Role of Metabolism in the Inflammatory Response of BV2 Microglial Cells. (2021) Antioxidants (Basel). 10(1). DOI: 10.3390/antiox10010109

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Maher, P., Currais, A., Schubert, D. Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases. (2020) Cell Chemical Biology. DOI: 10.1016/j.chembiol.2020.10.010

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Maher, P. Modulation of the Neuroprotective and Anti-inflammatory Activities of the Flavonol Fisetin by the Transition Metals Iron and Copper. (2020) Antioxidants (Basel). 9(11). DOI: 10.3390/antiox9111113

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Liang, Z., Currais, A., Soriano-Castell, D., Schubert, D., Maher, P. Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders. (2020) Pharmacol Ther.:107749 DOI: 10.1016/j.pharmthera.2020.107749

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Huang, L., McClatchy, D.B., Maher, P., Liang, Z., Diedrich, J.K., Soriano-Castell, D., Goldberg, J., Shokhirev, M., Yates, J.R., Schubert, D., Currais, A. Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death. (2020) Cell Death & Disease. 11(10):828. DOI: 10.1038/s41419-020-03020-9

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Gunesch, S., Soriano-Castell, D., Lamer, S., Schlosser, A., Maher, P., Decker, M. Development and Application of a Chemical Probe Based on a Neuroprotective Flavonoid Hybrid for Target Identification Using Activity-Based Protein Profiling. (2020) ACS Chem Neurosci. DOI: 10.1021/acschemneuro.0c00589

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Ates, G., Goldberg, J., Currais, A., Maher, P. CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimer's disease. (2020) Redox Biology. 36:101648. DOI: 10.1016/j.redox.2020.101648

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Goldberg, J., Currais, A., Ates, G., Huang, L., Shokhirev, M., Maher, P., Schubert, D. Targeting of intracellular Ca stores as a therapeutic strategy against age-related neurotoxicities. (2020) NPJ Aging and Mechanisms of Disease. 6:10. DOI: 10.1038/s41514-020-00048-1

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Aguirre, C.A., Concetta Morale, M., Peng, Q., Sanchez-Alavez, M., Cintrón-Colón, R., Feng, K., Fazelpour, S., Maher, P., Conti, B. Two single nucleotide polymorphisms in IL13 and IL13RA1 from individuals with idiopathic Parkinson's disease increase cellular susceptibility to oxidative stress. (2020) Brain, Behavior, and Immunity. 88:920-924. DOI: 10.1016/j.bbi.2020.04.007

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Goldberg, J., Currais, A., Ates, G., Huang, L., Shokhirev, M., Maher, P., Schubert, D. Targeting of intracellular Ca stores as a therapeutic strategy against age-related neurotoxicities. (2020) NPJ Aging and Mechanisms of Disease. 6(1):10. DOI: 10.1038/s41514-020-00048-1

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Maher, P.A. Using Plants as a Source of Potential Therapeutics for the Treatment of Alzheimer's Disease. (2020) Yale J Biol Med. 93(2):365-373.

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Hofmann, J., Fayez, S., Scheiner, M., Hoffmann, M., Oerter, S., Appelt-Menzel, A., Maher, P., Maurice, T., Bringmann, G., Decker, M. Sterubin: Enantioresolution and Configurational Stability, Enantiomeric Purity in Nature, and Neuroprotective Activity in Vitro and in Vivo. (2020) Chemistry. 26(32):7299-7308. DOI: 10.1002/chem.202001264

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Maher, P., Fischer, W., Liang, Z., Soriano-Castell, D., Pinto, A.F.M., Rebman, J., Currais, A. The Value of Herbarium Collections to the Discovery of Novel Treatments for Alzheimer's Disease, a Case Made With the Genus . (2020) Front Pharmacol. 11:208. DOI: 10.3389/fphar.2020.00208

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Gunesch, S., Hoffmann, M., Kiermeier, C., Fischer, W., Pinto, A.F.M., Maurice, T., Maher, P., Decker, M. 7-O-Esters of taxifolin with pronounced and overadditive effects in neuroprotection, anti-neuroinflammation, and amelioration of short-term memory impairment in vivo. (2020) Redox Biol. 29:101378. DOI: 10.1016/j.redox.2019.101378

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Dafre, A.L., Schmitz, A.E., Maher, P. Rapid and persistent loss of TXNIP in HT22 neuronal cells under carbonyl and hyperosmotic stress. (2019) Neurochemistry International.:104585 DOI: 10.1016/j.neuint.2019.104585

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Leclercq, K., Liefferinge, J.V., Albertini, G., Neveux, M., Dardenne, S., Mairet-Coello, G., Vandenplas, C., Deprez, T., Chong, S.A., Foerch, P., Bentea, E., Sato, H., Maher, P., Massie, A., Smolders, I., Kaminski, R.M. Anticonvulsant and antiepileptogenic effects of system inactivation in chronic epilepsy models. (2019) Epilepsia. 60(7):1412-1423. DOI: 10.1111/epi.16055

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Maher, P. The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases. (2019) International Journal of Molecular Sciences. 20(12). DOI: 10.3390/ijms20123056

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Schubert, D., Kepchia, D., Liang, Z., Dargusch, R., Goldberg, J., Maher, P. Efficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer's Disease. (2019) Molecular Neurobiology. 56(11):7719-7730. DOI: 10.1007/s12035-019-1637-8

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Dafre, A.L., Schmitz, A.E., Maher, P. Hyperosmotic Stress Initiates AMPK-Independent Autophagy and AMPK- and Autophagy-Independent Depletion of Thioredoxin 1 and Glyoxalase 2 in HT22 Nerve Cells. (2019) Oxid Med Cell Longev. 2019:2715810. DOI: 10.1155/2019/2715810

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Fischer, W., Currais, A., Liang, Z., Pinto, A., Maher, P. Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa. (2019) Redox Biol. 21:101089. DOI: 10.1016/j.redox.2018.101089

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Schubert, D., Currais, A., Goldberg, J., Finley, K., Petrascheck, M., Maher, P. Geroneuroprotectors: Effective Geroprotectors for the Brain. (2018) Trends in Pharmacological Sciences. 39(12):1004-1007. DOI: 10.1016/j.tips.2018.09.008

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Lewerenz, J., Ates, G., Methner, A., Conrad, M., Maher, P. Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System. (2018) Frontiers in Neuroscience. 12:214. DOI: 10.3389/fnins.2018.00214

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Maher, P., Conti, B. Deciphering the pathways that protect from IL-13-mediated potentiation of oxidative stress-induced dopaminergic nerve cell death. (2018) Cytokine. 103:114-120. DOI: 10.1016/j.cyto.2017.09.018

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Schramm, S., Huang, G., Gunesch, S., Lang, F., Roa, J., Högger, P., Sabaté, R., Maher, P., Decker, M. Regioselective synthesis of 7-O-esters of the flavonolignan silibinin and SARs lead to compounds with overadditive neuroprotective effects. (2018) Eur J Med Chem. 146:93-107. DOI: 10.1016/j.ejmech.2018.01.036

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Maher, P. Potentiation of glutathione loss and nerve cell death by the transition metals iron and copper: Implications for age-related neurodegenerative diseases. (2018) Free Radical Biology & Medicine. 115:92-104. DOI: 10.1016/j.freeradbiomed.2017.11.015

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Goldberg, J., Currais, A., Prior, M., Fischer, W., Chiruta, C., Ratliff, E., Daugherty, D., Dargusch, R., Finley, K., Esparza-Moltó, P.B., Cuezva, J.M., Maher, P., Petrascheck, M., Schubert, D. The mitochondrial ATP synthase is a shared drug target for aging and dementia. (2018) Aging Cell. 17(2). DOI: 10.1111/acel.12715

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Maher, P. Protective effects of fisetin and other berry flavonoids in Parkinson's disease. (2017) Food & Function. 8(9):3033-3042. DOI: 10.1039/c7fo00809k

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Daugherty, D., Goldberg, J., Fischer, W., Dargusch, R., Maher, P., Schubert, D. A novel Alzheimer's disease drug candidate targeting inflammation and fatty acid metabolism. (2017) Alzheimers Res Ther. 9(1):50. DOI: 10.1186/s13195-017-0277-3

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Dafre, A.L., Schmitz, A.E., Maher, P. Methylglyoxal-induced AMPK activation leads to autophagic degradation of thioredoxin 1 and glyoxalase 2 in HT22 nerve cells. (2017) Free Radical Biology & Medicine. 108:270-279. DOI: 10.1016/j.freeradbiomed.2017.03.028

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Currais, A., Farrokhi, C., Dargusch, R., Armando, A., Quehenberger, O., Schubert, D., Maher, P. Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse. (2017) J. Gerontol. A Biol. Sci. Med. Sci. 73(3):299-307. DOI: 10.1093/gerona/glx104

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Maher, P., van Leyen, K., Dey, P.N., Honrath, B., Dolga, A., Methner, A. The role of Ca(2+) in cell death caused by oxidative glutamate toxicity and ferroptosis. (2017) Cell Calcium. 70:47-55. DOI: 10.1016/j.ceca.2017.05.007

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Schmitz, A.E., de Souza, L.F., Dos Santos, B., Maher, P., Lopes, F.M., Londero, G.F., Klamt, F., Dafre, A.L. Methylglyoxal-Induced Protection Response and Toxicity: Role of Glutathione Reductase and Thioredoxin Systems. (2017) Neurotoxicity Research. 32(3):340-350. DOI: 10.1007/s12640-017-9738-5

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Mori, S., Sugama, S., Nguyen, W., Michel, T., Sanna, M.G., Sanchez-Alavez, M., Cintron-Colon, R., Moroncini, G., Kakinuma, Y., Maher, P., Conti, B. Lack of interleukin-13 receptor α1 delays the loss of dopaminergic neurons during chronic stress. (2017) Journal of Neuroinflammation. 14(1):88. DOI: 10.1186/s12974-017-0862-1

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Merckx, E., Albertini, G., Paterka, M., Jensen, C., Albrecht, P., Dietrich, M., Van Liefferinge, J., Bentea, E., Verbruggen, L., Demuyser, T., Deneyer, L., Lewerenz, J., van Loo, G., De Keyser, J., Sato, H., Maher, P., Methner, A., Massie, A. Absence of system xc(-) on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis. (2017) Journal of Neuroinflammation. 14(1):9. DOI: 10.1186/s12974-016-0787-0

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Currais, A., Fischer, W., Maher, P., Schubert, D. Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain. (2017) FASEB Journal. 31(1):5-10. DOI: 10.1096/fj.201601184

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Currais, A., Quehenberger, O., M Armando, A., Daugherty, D., Maher, P., Schubert, D. Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. (2016) NPJ Aging and Mechanisms of Disease. 2:16012. DOI: 10.1038/npjamd.2016.12

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Mori, S., Maher, P., Conti, B. Neuroimmunology of the Interleukins 13 and 4. (2016) Brain Sci. 6(2). DOI: 10.3390/brainsci6020018

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Currais, A., Farrokhi, C., Dargusch, R., Goujon-Svrzic, M., Maher, P. Dietary glycemic index modulates the behavioral and biochemical abnormalities associated with autism spectrum disorder. (2016) Molecular Psychiatry. 21(3):426-36. DOI: 10.1038/mp.2015.64

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McClatchy, D.B., Savas, J.N., Martínez-Bartolomé, S., Park, S.K., Maher, P., Powell, S.B., Yates, J.R. Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex. (2016) Molecular Psychiatry. 21(2):205-15. DOI: 10.1038/mp.2015.41

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Lewerenz, J., Maher, P. Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence? (2015) Frontiers in Neuroscience. 9:469. DOI: 10.3389/fnins.2015.00469

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Dafre, A.L., Goldberg, J., Wang, T., Spiegel, D.A., Maher, P. Methylglyoxal, the foe and friend of glyoxalase and Trx/TrxR systems in HT22 nerve cells. (2015) Free Radical Biology & Medicine. 89:8-19. DOI: 10.1016/j.freeradbiomed.2015.07.005

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Currais, A., Goldberg, J., Farrokhi, C., Chang, M., Prior, M., Dargusch, R., Daugherty, D., Armando, A., Quehenberger, O., Maher, P., Schubert, D. A comprehensive multiomics approach toward understanding the relationship between aging and dementia. (2015) Aging. 7(11):937-55. DOI: 10.18632/aging.100838

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Krasieva, T.B., Ehren, J., O'Sullivan, T., Tromberg, B.J., Maher, P. Cell and brain tissue imaging of the flavonoid fisetin using label-free two-photon microscopy. (2015) Neurochem. Int. 89:243-8. DOI: 10.1016/j.neuint.2015.08.003

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Maher, P. How fisetin reduces the impact of age and disease on CNS function. (2015) Frontiers in Bioscience. 7:58-82.

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Maher, P., Kontoghiorghes, G.J. Characterization of the neuroprotective potential of derivatives of the iron chelating drug deferiprone. (2015) Neurochemical Research. 40(3):609-20. DOI: 10.1007/s11064-014-1508-7

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Currais, A., Chiruta, C., Goujon-Svrzic, M., Costa, G., Santos, T., Batista, M.T., Paiva, J., do Céu Madureira, M., Maher, P. Screening and identification of neuroprotective compounds relevant to Alzheimer׳s disease from medicinal plants of S. Tomé e Príncipe. (2014) Journal of Ethnopharmacology. 155(1):830-40. DOI: 10.1016/j.jep.2014.06.046

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Prior, M., Chiruta, C., Currais, A., Goldberg, J., Ramsey, J., Dargusch, R., Maher, P.A., Schubert, D. Back to the future with phenotypic screening. (2014) ACS Chem Neurosci. 5(7):503-13. DOI: 10.1021/cn500051h

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Currais, A., Prior, M., Dargusch, R., Armando, A., Ehren, J., Schubert, D., Quehenberger, O., Maher, P. Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. (2014) Aging Cell. 13(2):379-90. DOI: 10.1111/acel.12185

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Maher, P. Proteasome Assay in Cell Lysates. (2014) Bio Protocol. 4(2).

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Currais, A., Maher, P. Functional consequences of age-dependent changes in glutathione status in the brain. (2013) Antioxid. Redox Signal. 19(8):813-22. DOI: 10.1089/ars.2012.4996

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Valera, E., Dargusch, R., Maher, P.A., Schubert, D. Modulation of 5-lipoxygenase in proteotoxicity and Alzheimer's disease. (2013) Journal of Neuroscience. 33(25):10512-25. DOI: 10.1523/JNEUROSCI.5183-12.2013

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Ehren, J.L., Maher, P. Concurrent regulation of the transcription factors Nrf2 and ATF4 mediates the enhancement of glutathione levels by the flavonoid fisetin. (2013) Biochem. Pharmacol. 85(12):1816-26. DOI: 10.1016/j.bcp.2013.04.010

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Currais, A., Prior, M., Lo, D., Jolivalt, C., Schubert, D., Maher, P. Diabetes exacerbates amyloid and neurovascular pathology in aging-accelerated mice. (2012) Aging Cell. 11(6):1017-26. DOI: 10.1111/acel.12002

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Schubert, D., Maher, P. An alternative approach to drug discovery for Alzheimer's disease dementia. (2012) Future Medicinal Chemistry. 4(13):1681-8. DOI: 10.4155/fmc.12.109

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Maher, P. Methylglyoxal, advanced glycation end products and autism: is there a connection? (2012) Medical Hypotheses. 78(4):548-52. DOI: 10.1016/j.mehy.2012.01.032

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Chiruta, C., Schubert, D., Dargusch, R., Maher, P. Chemical modification of the multitarget neuroprotective compound fisetin. (2012) Journal of Medicinal Chemistry. 55(1):378-89. DOI: 10.1021/jm2012563

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Chen, Q., Prior, M., Dargusch, R., Roberts, A., Riek, R., Eichmann, C., Chiruta, C., Akaishi, T., Abe, K., Maher, P., Schubert, D. A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. (2011) PLOS One. 6(12):e27865. DOI: 10.1371/journal.pone.0027865

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Maher, P., Dargusch, R., Ehren, J.L., Okada, S., Sharma, K., Schubert, D. Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. (2011) PLOS One. 6(6):e21226. DOI: 10.1371/journal.pone.0021226

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Lapchak, P.A., Schubert, D.R., Maher, P.A. De-Risking of Stilbazulenyl Nitrone (STAZN), a Lipophilic Nitrone to Treat Stroke Using a Unique Panel of In Vitro Assays. (2011) Transl Stroke Res. 2(2):209-17. DOI: 10.1007/s12975-011-0071-7

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Maher, P., Dargusch, R., Bodai, L., Gerard, P.E., Purcell, J.M., Marsh, J.L. ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. (2011) Human Molecular Genetics. 20(2):261-70. DOI: 10.1093/hmg/ddq460

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Lapchak, P.A., Schubert, D.R., Maher, P.A. Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke. (2011) J. Neurochem. 116(1):122-31. DOI: 10.1111/j.1471-4159.2010.07090.x

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Maher, P., Akaishi, T., Schubert, D., Abe, K. A pyrazole derivative of curcumin enhances memory. (2010) Neurobiology of Aging. 31(4):706-9. DOI: 10.1016/j.neurobiolaging.2008.05.020

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Maher, P. Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin. (2009) Genes & Nutrition. 4(4):297-307. DOI: 10.1007/s12263-009-0142-5

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Lewerenz, J., Albrecht, P., Tien, M.L., Henke, N., Karumbayaram, S., Kornblum, H.I., Wiedau-Pazos, M., Schubert, D., Maher, P., Methner, A. Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro. (2009) J. Neurochem. 111(2):332-43. DOI: 10.1111/j.1471-4159.2009.06347.x

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Herrera, F., Chen, Q., Fischer, W.H., Maher, P., Schubert, D.R. Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down's syndrome. (2009) Cell Death and Differentiation. 16(6):910-20. DOI: 10.1038/cdd.2009.24

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Maher, P.A., Schubert, D.R. Metabolic links between diabetes and Alzheimer's disease. (2009) Expert Rev Neurother. 9(5):617-30. DOI: 10.1586/ern.09.18

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Schubert, D., Herrera, F., Cumming, R., Read, J., Low, W., Maher, P., Fischer, W.H. Neural cells secrete a unique repertoire of proteins. (2009) J. Neurochem. 109(2):427-35. DOI: 10.1111/j.1471-4159.2009.05968.x

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Lewerenz, J., Maher, P. Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression. (2009) Journal of Biological Chemistry. 284(2):1106-15. DOI: 10.1074/jbc.M807325200

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Maher, P., Lewerenz, J., Lozano, C., Torres, J.L. A novel approach to enhancing cellular glutathione levels. (2008) J. Neurochem. 107(3):690-700. DOI: 10.1111/j.1471-4159.2008.05620.x

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Maher, P. The flavonoid fisetin promotes nerve cell survival from trophic factor withdrawal by enhancement of proteasome activity. (2008) Arch. Biochem. Biophys. 476(2):139-44. DOI: 10.1016/j.abb.2008.03.023

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Maher, P. Proteasome inhibitors prevent oxidative stress-induced nerve cell death by a novel mechanism. (2008) Biochem. Pharmacol. 75(10):1994-2006. DOI: 10.1016/j.bcp.2008.02.008

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Liu, Y., Dargusch, R., Maher, P., Schubert, D. A broadly neuroprotective derivative of curcumin. (2008) J. Neurochem. 105(4):1336-45. DOI: 10.1111/j.1471-4159.2008.05236.x

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Maher, P., Hanneken, A. Flavonoids protect retinal ganglion cells from ischemia in vitro. (2008) Experimental Eye Research. 86(2):366-74. DOI: 10.1016/j.exer.2007.11.009

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Burdo, J., Schubert, D., Maher, P. Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons. (2008) Brain Research. 1189:12-22. DOI: 10.1016/j.brainres.2007.10.077

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Lapchak, P.A., Maher, P., Schubert, D., Zivin, J.A. Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes. (2007) Neuroscience. 150(3):585-91. DOI: 10.1016/j.neuroscience.2007.09.033

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Maher, P., Salgado, K.F., Zivin, J.A., Lapchak, P.A. A novel approach to screening for new neuroprotective compounds for the treatment of stroke. (2007) Brain Research. 1173:117-25. DOI: 10.1016/j.brainres.2007.07.061

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Maher, P. Redox control of neural function: background, mechanisms, and significance. (2006) Antioxid. Redox Signal. 8(11-12):1941-70. DOI: 10.1089/ars.2006.8.1941

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Maher, P., Akaishi, T., Abe, K. Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(44):16568-73. DOI: 10.1073/pnas.0607822103

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Maher, P. A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives. (2006) Free Radic. Res. 40(10):1105-11. DOI: 10.1080/10715760600672509

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Maher, P., Hanneken, A. Flavonoids protect retinal ganglion cells from oxidative stress-induced death. (2005) Investigative Ophthalmology & Visual Science. 46(12):4796-803. DOI: 10.1167/iovs.05-0397

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Maher, P. The effects of stress and aging on glutathione metabolism. (2005) Ageing Research Reviews. 4(2):288-314. DOI: 10.1016/j.arr.2005.02.005

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Conti, B., Sugama, S., Lucero, J., Winsky-Sommerer, R., Wirz, S.A., Maher, P., Andrews, Z., Barr, A.M., Morale, M.C., Paneda, C., Pemberton, J., Gaidarova, S., Behrens, M.M., Beal, F., Sanna, P.P., Horvath, T., Bartfai, T. Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity. (2005) Journal of Neurochemistry. 93(2):493-501. DOI: 10.1111/j.1471-4159.2005.03052.x

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Maher, P., Hanneken, A. The molecular basis of oxidative stress-induced cell death in an immortalized retinal ganglion cell line. (2005) Investigative Ophthalmology & Visual Science. 46(2):749-57. DOI: 10.1167/iovs.04-0883

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Soucek, T., Cumming, R., Dargusch, R., Maher, P., Schubert, D. The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide. (2003) Neuron. 39(1):43-56. DOI: 10.1016/s0896-6273(03)00367-2

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Tan, S., Schubert, D., Maher, P. Oxytosis: A novel form of programmed cell death. (2001) Current Topics in Medicinal Chemistry. 1(6):497-506.

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Chen, Q., Yoshida, H., Schubert, D., Maher, P., Mallory, M., Masliah, E. Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation. (2001) Am. J. Pathol. 159(5):1597-602. DOI: 10.1016/S0002-9440(10)63005-2

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Tan, S., Somia, N., Maher, P., Schubert, D. Regulation of antioxidant metabolism by translation initiation factor 2alpha. (2001) Journal of Cell Biology. 152(5):997-1006.

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Maher, P., Schubert, D. Signaling by reactive oxygen species in the nervous system. (2000) Cellular and Molecular Life Sciences. 57(8-9):1287-305.

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Sagara, Y., Dargusch, R., Chambers, D., Davis, J., Schubert, D., Maher, P. Cellular mechanisms of resistance to chronic oxidative stress. (1998) Free Radical Biology & Medicine. 24(9):1375-89.

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Tan, S., Sagara, Y., Liu, Y., Maher, P., Schubert, D. The regulation of reactive oxygen species production during programmed cell death. (1998) Journal of Cell Biology. 141(6):1423-32.

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Li, Y., Maher, P., Schubert, D. Phosphatidylcholine-specific phospholipase C regulates glutamate-induced nerve cell death. (1998) Proceedings of the National Academy of Sciences of the United States of America. 95(13):7748-53. DOI: 10.1073/pnas.95.13.7748

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Sagara, Y., Tan, S., Maher, P., Schubert, D. Mechanisms of resistance to oxidative stress in Alzheimer's disease. (1998) Biofactors. 8(1-2):45-50.

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Li, Y., Maher, P., Schubert, D. Requirement for cGMP in nerve cell death caused by glutathione depletion. (1997) Journal of Cell Biology. 139(5):1317-24.

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Tan, S., Maher, P., Schubert, D. The role of protein phosphorylation in beta amyloid toxicity. (1997) Brain Research. 765(1):159-63.

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Li, Y., Maher, P., Schubert, D. A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion. (1997) Neuron. 19(2):453-63.

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Davis, J.B., Maher, P. Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line. (1994) Brain Research. 652(1):169-73. DOI: 10.1016/0006-8993(94)90334-4

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Schubert, D., Kimura, H., Maher, P. Growth factors and vitamin E modify neuronal glutamate toxicity. (1992) Proceedings of the National Academy of Sciences of the United States of America. 89(17):8264-7.

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Education

BSc, Biochemistry, McGill University, Montreal, Quebec, Canada
PhD, Biochemistry, University of British Columbia, Vancouver, BC, Canada
Postdoc, Cell Biology, University of California, San Diego


Awards & Honors

  • Edward N. & Della L. Thome Memorial Foundation Award in Alzheimer's Disease Drug Discovery, 2015
  • Michael J. Fox Foundation Award for Novel Approaches to Drug Discovery for Parkinson's Disease, 2007
  • NIH Postdoctoral Fellowship, 1982
  • Anna Fuller Postdoctoral Fellowship, 1980
  • Killam Predoctoral Fellowship, 1979