Marc Montminy

Professor

Clayton Foundation Laboratories for Peptide Biology

J.W. Kieckhefer Foundation Chair

Marc Montminy
Salk Institute for Biological Studies - Publications

all Publications


Sonntag, T., Moresco, J.J., Yates, J.R., Montminy, M. The KLDpT activation loop motif is critical for MARK kinase activity. (2019) PLOS One. 14(12):e0225727. DOI: 10.1371/journal.pone.0225727

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Rodón, L., Svensson, R.U., Wiater, E., Chun, M.G.H., Tsai, W.W., Eichner, L.J., Shaw, R.J., Montminy, M. The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer. (2019) Science Advances. 5(7):eaaw6455. DOI: 10.1126/sciadv.aaw6455

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Van de Velde, S., Wiater, E., Tran, M., Hwang, Y., Cole, P.A., Montminy, M. CREB promotes beta cell gene expression by targeting Its coactivators to tissue-specific enhancers. (2019) Molecular and Cellular Biology. DOI: 10.1128/MCB.00200-19

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Tasoulas, J., Rodon, L., Kaye, F.J., Montminy, M., Amelio, A.L. Adaptive Transcriptional Responses by CRTC Coactivators in Cancer. (2019) Trends in Cancer. 5(2):111-127. DOI: 10.1016/j.trecan.2018.12.002

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Sonntag, T., Ostojić, J., Vaughan, J.M., Moresco, J.J., Yoon, Y.S., Yates, J.R., Montminy, M. Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. (2018) iScience. 11:134-145. DOI: 10.1016/j.isci.2018.12.012

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Yoon, Y.S., Tsai, W.W., Van de Velde, S., Chen, Z., Lee, K.F., Morgan, D.A., Rahmouni, K., Matsumura, S., Wiater, E., Song, Y., Montminy, M. cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis. (2018) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1805257115

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Ritchie, A.I., Singanayagam, A., Wiater, E., Edwards, M.R., Montminy, M., Johnston, S.L. β2-Agonists Enhance Asthma-Relevant Inflammatory Mediators in Human Airway Epithelial Cells. (2018) Am. J. Respir. Cell Mol. Biol. 58(1):128-132. DOI: 10.1165/rcmb.2017-0315LE


Sonntag, T., Vaughan, J.M., Montminy, M. 14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs). (2017) FEBS Journal. DOI: 10.1111/febs.14351

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Kim, J.H., Hedrick, S., Tsai, W.W., Wiater, E., Le Lay, J., Kaestner, K.H., Leblanc, M., Loar, A., Montminy, M. CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis. (2017) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1712616114

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Sonntag, T., Moresco, J.J., Vaughan, J.M., Matsumura, S., Yates, J.R., Montminy, M. Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members. (2017) PLOS One. 12(2):e0173013. DOI: 10.1371/journal.pone.0173013

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Shen, R., Wang, B., Giribaldi, M.G., Ayres, J., Thomas, J.B., Montminy, M. Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(23):E3307-14. DOI: 10.1073/pnas.1606106113

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Ravnskjaer, K., Madiraju, A., Montminy, M. Role of the cAMP Pathway in Glucose and Lipid Metabolism. (2016) Handbook of Experimental Pharmacology. 233:29-49. DOI: 10.1007/164_2015_32

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Luan, B., Yoon, Y.S., Le Lay, J., Kaestner, K.H., Hedrick, S., Montminy, M. CREB pathway links PGE2 signaling with macrophage polarization. (2015) Proceedings of the National Academy of Sciences of the United States of America. 112(51):15642-7. DOI: 10.1073/pnas.1519644112

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Hogan, M.F., Ravnskjaer, K., Matsumura, S., Huising, M.O., Hull, R.L., Kahn, S.E., Montminy, M. Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2. (2015) Journal of Biological Chemistry. 290(43):25997-6006. DOI: 10.1074/jbc.M115.679266

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Hernandez, J.B., Chang, C., LeBlanc, M., Grimm, D., Le Lay, J., Kaestner, K.H., Zheng, Y., Montminy, M. The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation. (2015) Nature Communications. 6:7216. DOI: 10.1038/ncomms8216

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Tsai, W.W., Matsumura, S., Liu, W., Phillips, N.G., Sonntag, T., Hao, E., Lee, S., Hai, T., Montminy, M. ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis. (2015) Proceedings of the National Academy of Sciences of the United States of America. 112(9):2699-704. DOI: 10.1073/pnas.1424641112

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Blanchet, E., Van de Velde, S., Matsumura, S., Hao, E., LeLay, J., Kaestner, K., Montminy, M. Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance. (2015) Cell Reports. 10(7):1149-57. DOI: 10.1016/j.celrep.2015.01.046

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Paz, J.C., Park, S., Phillips, N., Matsumura, S., Tsai, W.W., Kasper, L., Brindle, P.K., Zhang, G., Zhou, M.M., Wright, P.E., Montminy, M. Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(48):17116-21. DOI: 10.1073/pnas.1420389111

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Luan, B., Goodarzi, M.O., Phillips, N.G., Guo, X., Chen, Y.D., Yao, J., Allison, M., Rotter, J.I., Shaw, R., Montminy, M. Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. (2014) Cell Metabolism. 19(6):1058-65. DOI: 10.1016/j.cmet.2014.03.024

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Ravnskjaer, K., Hogan, M.F., Lackey, D., Tora, L., Dent, S.Y., Olefsky, J., Montminy, M. Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. (2013) Journal of Clinical Investigation. 123(10):4318-28. DOI: 10.1172/JCI69035

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Tsai, W.W., Niessen, S., Goebel, N., Yates, J.R., Guccione, E., Montminy, M. PRMT5 modulates the metabolic response to fasting signals. (2013) Proceedings of the National Academy of Sciences of the United States of America. 110(22):8870-5. DOI: 10.1073/pnas.1304602110

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Yu, J., Deng, R., Zhu, H.H., Zhang, S.S., Zhu, C., Montminy, M., Davis, R., Feng, G.S. Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2. (2013) Journal of Biological Chemistry. 288(6):3823-30. DOI: 10.1074/jbc.M112.397885

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Luo, Q., Viste, K., Urday-Zaa, J.C., Senthil Kumar, G., Tsai, W.W., Talai, A., Mayo, K.E., Montminy, M., Radhakrishnan, I. Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(51):20865-70. DOI: 10.1073/pnas.1219028109

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Wang, Y., Li, G., Goode, J., Paz, J.C., Ouyang, K., Screaton, R., Fischer, W.H., Chen, J., Tabas, I., Montminy, M. Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes. (2012) Nature. 485(7396):128-32. DOI: 10.1038/nature10988

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Montminy, M., Lee, K.F., Rivier, J.E., Rivier, C., Reichlin, S. Wylie Vale: neuroendocrine master. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(10):3604-5. DOI: 10.1073/pnas.1201696109


Van de Velde, S., Hogan, M.F., Montminy, M. mTOR links incretin signaling to HIF induction in pancreatic beta cells. (2011) Proceedings of the National Academy of Sciences of the United States of America. 108(41):16876-82. DOI: 10.1073/pnas.1114228108

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Stewart, R., Flechner, L., Montminy, M., Berdeaux, R. CREB is activated by muscle injury and promotes muscle regeneration. (2011) PLOS One. 6(9):e24714. DOI: 10.1371/journal.pone.0024714

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Mihaylova, M.M., Vasquez, D.S., Ravnskjaer, K., Denechaud, P.D., Yu, R.T., Alvarez, J.G., Downes, M., Evans, R.M., Montminy, M., Shaw, R.J. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. (2011) Cell. 145(4):607-21. DOI: 10.1016/j.cell.2011.03.043

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Wang, B., Moya, N., Niessen, S., Hoover, H., Mihaylova, M.M., Shaw, R.J., Yates, J.R., Fischer, W.H., Thomas, J.B., Montminy, M. A hormone-dependent module regulating energy balance. (2011) Cell. 145(4):596-606. DOI: 10.1016/j.cell.2011.04.013

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Altarejos, J.Y., Montminy, M. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. (2011) Nature Reviews. Molecular Cell Biology. 12(3):141-51. DOI: 10.1038/nrm3072

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Mair, W., Morantte, I., Rodrigues, A.P., Manning, G., Montminy, M., Shaw, R.J., Dillin, A. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. (2011) Nature. 470(7334):404-8. DOI: 10.1038/nature09706

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Song, Y., Altarejos, J., Goodarzi, M.O., Inoue, H., Guo, X., Berdeaux, R., Kim, J.H., Goode, J., Igata, M., Paz, J.C., Hogan, M.F., Singh, P.K., Goebel, N., Vera, L., Miller, N., Cui, J., Jones, M.R., , , Chen, Y.D., Taylor, K.D., Hsueh, W.A., Rotter, J.I., Montminy, M. CRTC3 links catecholamine signalling to energy balance. (2010) Nature. 468(7326):933-9. DOI: 10.1038/nature09564

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Yoon, Y.S., Lee, M.W., Ryu, D., Kim, J.H., Ma, H., Seo, W.Y., Kim, Y.N., Kim, S.S., Lee, C.H., Hunter, T., Choi, C.S., Montminy, M.R., Koo, S.H. Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(41):17704-9. DOI: 10.1073/pnas.1012665107

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Zhang, E.E., Liu, Y., Dentin, R., Pongsawakul, P.Y., Liu, A.C., Hirota, T., Nusinow, D.A., Sun, X., Landais, S., Kodama, Y., Brenner, D.A., Montminy, M., Kay, S.A. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. (2010) Nature Medicine. 16(10):1152-6. DOI: 10.1038/nm.2214

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Zmuda, E.J., Qi, L., Zhu, M.X., Mirmira, R.G., Montminy, M.R., Hai, T. The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. (2010) Molecular Endocrinology. 24(7):1423-33. DOI: 10.1210/me.2009-0463

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Wang, Y., Inoue, H., Ravnskjaer, K., Viste, K., Miller, N., Liu, Y., Hedrick, S., Vera, L., Montminy, M. Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(7):3087-92. DOI: 10.1073/pnas.0914897107

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Wang, Y., Vera, L., Fischer, W.H., Montminy, M. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. (2009) Nature. 460(7254):534-7. DOI: 10.1038/nature08111

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Qi, L., Saberi, M., Zmuda, E., Wang, Y., Altarejos, J., Zhang, X., Dentin, R., Hedrick, S., Bandyopadhyay, G., Hai, T., Olefsky, J., Montminy, M. Adipocyte CREB promotes insulin resistance in obesity. (2009) Cell Metabolism. 9(3):277-86. DOI: 10.1016/j.cmet.2009.01.006

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Ryu, D., Oh, K.J., Jo, H.Y., Hedrick, S., Kim, Y.N., Hwang, Y.J., Park, T.S., Han, J.S., Choi, C.S., Montminy, M., Koo, S.H. TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1. (2009) Cell Metabolism. 9(3):240-51. DOI: 10.1016/j.cmet.2009.01.007

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Liu, Y., Dentin, R., Chen, D., Hedrick, S., Ravnskjaer, K., Schenk, S., Milne, J., Meyers, D.J., Cole, P., Yates, J., Olefsky, J., Guarente, L., Montminy, M. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. (2008) Nature. 456(7219):269-73. DOI: 10.1038/nature07349

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Altarejos, J.Y., Goebel, N., Conkright, M.D., Inoue, H., Xie, J., Arias, C.M., Sawchenko, P.E., Montminy, M. The Creb1 coactivator Crtc1 is required for energy balance and fertility. (2008) Nature Medicine. 14(10):1112-7. DOI: 10.1038/nm.1866

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Wang, B., Goode, J., Best, J., Meltzer, J., Schilman, P.E., Chen, J., Garza, D., Thomas, J.B., Montminy, M. The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila. (2008) Cell Metabolism. 7(5):434-44. DOI: 10.1016/j.cmet.2008.02.010

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Dentin, R., Hedrick, S., Xie, J., Yates, J., Montminy, M. Hepatic glucose sensing via the CREB coactivator CRTC2. (2008) Science. 319(5868):1402-5. DOI: 10.1126/science.1151363

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Dentin, R., Liu, Y., Koo, S.H., Hedrick, S., Vargas, T., Heredia, J., Yates, J., Montminy, M. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. (2007) Nature. 449(7160):366-9. DOI: 10.1038/nature06128

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Ravnskjaer, K., Kester, H., Liu, Y., Zhang, X., Lee, D., Yates, J.R., Montminy, M. Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. (2007) EMBO Journal. 26(12):2880-9. DOI: 10.1038/sj.emboj.7601715

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Berdeaux, R., Goebel, N., Banaszynski, L., Takemori, H., Wandless, T., Shelton, G.D., Montminy, M. SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. (2007) Nature Medicine. 13(5):597-603. DOI: 10.1038/nm1573

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Koo, S.H., Montminy, M. In vino veritas: a tale of two sirt1s? (2006) Cell. 127(6):1091-3. DOI: 10.1016/j.cell.2006.11.034

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Qi, L., Heredia, J.E., Altarejos, J.Y., Screaton, R., Goebel, N., Niessen, S., Macleod, I.X., Liew, C.W., Kulkarni, R.N., Bain, J., Newgard, C., Nelson, M., Evans, R.M., Yates, J., Montminy, M. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. (2006) Science. 312(5781):1763-6. DOI: 10.1126/science.1123374

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Liu, Y., Montminy, M. CAT in the HAT: catabolic inhibition by the histone acetyltransferase GCN5. (2006) Cell Metabolism. 3(6):387-8. DOI: 10.1016/j.cmet.2006.05.006

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Cho, C.Y., Koo, S.H., Wang, Y., Callaway, S., Hedrick, S., Mak, P.A., Orth, A.P., Peters, E.C., Saez, E., Montminy, M., Schultz, P.G., Chanda, S.K. Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling. (2006) Cell Metabolism. 3(5):367-78. DOI: 10.1016/j.cmet.2006.03.006

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Zhang, W., Patil, S., Chauhan, B., Guo, S., Powell, D.R., Le, J., Klotsas, A., Matika, R., Xiao, X., Franks, R., Heidenreich, K.A., Sajan, M.P., Farese, R.V., Stolz, D.B., Tso, P., Koo, S.H., Montminy, M., Unterman, T.G. FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. (2006) Journal of Biological Chemistry. 281(15):10105-17. DOI: 10.1074/jbc.M600272200

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Koo, S.H., Montminy, M. Fatty acids and insulin resistance: a perfect storm. (2006) Molecular Cell. 21(4):449-50. DOI: 10.1016/j.molcel.2006.02.001

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Shaw, R.J., Lamia, K.A., Vasquez, D., Koo, S.H., Bardeesy, N., Depinho, R.A., Montminy, M., Cantley, L.C. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. (2005) Science. 310(5754):1642-6. DOI: 10.1126/science.1120781

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Canettieri, G., Koo, S.H., Berdeaux, R., Heredia, J., Hedrick, S., Zhang, X., Montminy, M. Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling. (2005) Cell Metabolism. 2(5):331-8. DOI: 10.1016/j.cmet.2005.09.008

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Lebrun, P., Montminy, M.R., Van Obberghen, E. Regulation of the pancreatic duodenal homeobox-1 protein by DNA-dependent protein kinase. (2005) Journal of Biological Chemistry. 280(46):38203-10. DOI: 10.1074/jbc.M504842200

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Koo, S.H., Flechner, L., Qi, L., Zhang, X., Screaton, R.A., Jeffries, S., Hedrick, S., Xu, W., Boussouar, F., Brindle, P., Takemori, H., Montminy, M. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. (2005) Nature. 437(7062):1109-11. DOI: 10.1038/nature03967

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Conkright, M.D., Montminy, M. CREB: the unindicted cancer co-conspirator. (2005) Trends in Cell Biology. 15(9):457-9. DOI: 10.1016/j.tcb.2005.07.007

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Park, J.M., Greten, F.R., Wong, A., Westrick, R.J., Arthur, J.S., Otsu, K., Hoffmann, A., Montminy, M., Karin, M. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. (2005) Immunity. 23(3):319-29. DOI: 10.1016/j.immuni.2005.08.010

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Gardner, K.H., Montminy, M. Can you hear me now? Regulating transcriptional activators by phosphorylation. (2005) Science STKE. 2005(301):pe44. DOI: 10.1126/stke.3012005pe44

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Mayr, B.M., Guzman, E., Montminy, M. Glutamine rich and basic region/leucine zipper (bZIP) domains stabilize cAMP-response element-binding protein (CREB) binding to chromatin. (2005) Journal of Biological Chemistry. 280(15):15103-10. DOI: 10.1074/jbc.M414144200

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Zhang, X., Odom, D.T., Koo, S.H., Conkright, M.D., Canettieri, G., Best, J., Chen, H., Jenner, R., Herbolsheimer, E., Jacobsen, E., Kadam, S., Ecker, J.R., Emerson, B., Hogenesch, J.B., Unterman, T., Young, R.A., Montminy, M. Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. (2005) Proceedings of the National Academy of Sciences of the United States of America. 102(12):4459-64. DOI: 10.1073/pnas.0501076102

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Best, J.L., Amezcua, C.A., Mayr, B., Flechner, L., Murawsky, C.M., Emerson, B., Zor, T., Gardner, K.H., Montminy, M. Identification of small-molecule antagonists that inhibit an activator: coactivator interaction. (2004) Proceedings of the National Academy of Sciences of the United States of America. 101(51):17622-7. DOI: 10.1073/pnas.0406374101

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Montminy, M., Koo, S.H. Diabetes: outfoxing insulin resistance? (2004) Nature. 432(7020):958-9. DOI: 10.1038/432958a


Screaton, R.A., Conkright, M.D., Katoh, Y., Best, J.L., Canettieri, G., Jeffries, S., Guzman, E., Niessen, S., Yates, J.R., Takemori, H., Okamoto, M., Montminy, M. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (2004) Cell. 119(1):61-74. DOI: 10.1016/j.cell.2004.09.015

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Kulkarni, R.N., Jhala, U.S., Winnay, J.N., Krajewski, S., Montminy, M., Kahn, C.R. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. (2004) Journal of Clinical Investigation. 114(6):828-36. DOI: 10.1172/JCI21845

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Koo, S.H., Satoh, H., Herzig, S., Lee, C.H., Hedrick, S., Kulkarni, R., Evans, R.M., Olefsky, J., Montminy, M. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. (2004) Nature Medicine. 10(5):530-4. DOI: 10.1038/nm1044

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Montminy, M., Koo, S.H., Zhang, X. The CREB family: key regulators of hepatic metabolism. (2004) Ann. Endocrinol. (Paris). 65(1):73-5.


Herzig, S., Hedrick, S., Morantte, I., Koo, S.H., Galimi, F., Montminy, M. CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma. (2003) Nature. 426(6963):190-3. DOI: 10.1038/nature02110

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Conkright, M.D., Canettieri, G., Screaton, R., Guzman, E., Miraglia, L., Hogenesch, J.B., Montminy, M. TORCs: transducers of regulated CREB activity. (2003) Molecular Cell. 12(2):413-23.

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Jhala, U.S., Canettieri, G., Screaton, R.A., Kulkarni, R.N., Krajewski, S., Reed, J., Walker, J., Lin, X., White, M., Montminy, M. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. (2003) Genes & Development. 17(13):1575-80. DOI: 10.1101/gad.1097103

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Du, K., Herzig, S., Kulkarni, R.N., Montminy, M. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. (2003) Science. 300(5625):1574-7. DOI: 10.1126/science.1079817

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Conkright, M.D., Guzmán, E., Flechner, L., Su, A.I., Hogenesch, J.B., Montminy, M. Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness. (2003) Molecular Cell. 11(4):1101-8.

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Canettieri, G., Morantte, I., Guzmán, E., Asahara, H., Herzig, S., Anderson, S.D., Yates, J.R., Montminy, M. Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex. (2003) Nature Structural Biology. 10(3):175-81. DOI: 10.1038/nsb895

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Zor, T., Mayr, B.M., Dyson, H.J., Montminy, M.R., Wright, P.E. Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators. (2002) Journal of Biological Chemistry. 277(44):42241-8. DOI: 10.1074/jbc.M207361200

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Asahara, H., Tartare-Deckert, S., Nakagawa, T., Ikehara, T., Hirose, F., Hunter, T., Ito, T., Montminy, M. Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. (2002) Molecular and Cellular Biology. 22(9):2974-83.

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Kushner, J.A., Ye, J., Schubert, M., Burks, D.J., Dow, M.A., Flint, C.L., Dutta, S., Wright, C.V., Montminy, M.R., White, M.F. Pdx1 restores beta cell function in Irs2 knockout mice. (2002) Journal of Clinical Investigation. 109(9):1193-201. DOI: 10.1172/JCI14439

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Asahara, H., Santoso, B., Guzman, E., Du, K., Cole, P.A., Davidson, I., Montminy, M. Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB. (2001) Molecular and Cellular Biology. 21(23):7892-900. DOI: 10.1128/MCB.21.23.7892-7900.2001

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Xu, W., Chen, H., Du, K., Asahara, H., Tini, M., Emerson, B.M., Montminy, M., Evans, R.M. A transcriptional switch mediated by cofactor methylation. (2001) Science. 294(5551):2507-11. DOI: 10.1126/science.1065961

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Herzig, S., Long, F., Jhala, U.S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., Spiegelman, B., Montminy, M. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. (2001) Nature. 413(6852):179-83. DOI: 10.1038/35093131

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Mayr, B.M., Canettieri, G., Montminy, M.R. Distinct effects of cAMP and mitogenic signals on CREB-binding protein recruitment impart specificity to target gene activation via CREB. (2001) Proceedings of the National Academy of Sciences of the United States of America. 98(19):10936-41. DOI: 10.1073/pnas.191152098

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Mayr, B., Montminy, M. Transcriptional regulation by the phosphorylation-dependent factor CREB. (2001) Nature Reviews. Molecular Cell Biology. 2(8):599-609. DOI: 10.1038/35085068

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Long, F., Schipani, E., Asahara, H., Kronenberg, H., Montminy, M. The CREB family of activators is required for endochondral bone development. (2001) Development. 128(4):541-50.

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Dutta, S., Gannon, M., Peers, B., Wright, C., Bonner-Weir, S., Montminy, M. PDX:PBX complexes are required for normal proliferation of pancreatic cells during development. (2001) Proceedings of the National Academy of Sciences of the United States of America. 98(3):1065-70. DOI: 10.1073/pnas.031561298

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Frangioni, J.V., LaRiccia, L.M., Cantley, L.C., Montminy, M.R. Minimal activators that bind to the KIX domain of p300/CBP identified by phage display screening. (2000) Nature Biotechnology. 18(10):1080-5. DOI: 10.1038/80280

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von Mikecz, A., Zhang, S., Montminy, M., Tan, E.M., Hemmerich, P. CREB-binding protein (CBP)/p300 and RNA polymerase II colocalize in transcriptionally active domains in the nucleus. (2000) Journal of Cell Biology. 150(1):265-73.

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Du, K., Asahara, H., Jhala, U.S., Wagner, B.L., Montminy, M. Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo. (2000) Molecular and Cellular Biology. 20(12):4320-7.

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Wagner, B.L., Bauer, A., Schütz, G., Montminy, M. Stimulus-specific interaction between activator-coactivator cognates revealed with a novel complex-specific antiserum. (2000) Journal of Biological Chemistry. 275(12):8263-6.

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Michael, L.F., Asahara, H., Shulman, A.I., Kraus, W.L., Montminy, M. The phosphorylation status of a cyclic AMP-responsive activator is modulated via a chromatin-dependent mechanism. (2000) Molecular and Cellular Biology. 20(5):1596-603.

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Asahara, H., Dutta, S., Kao, H.Y., Evans, R.M., Montminy, M. Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner. (1999) Molecular and Cellular Biology. 19(12):8219-25.

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Malecki, M.T., Jhala, U.S., Antonellis, A., Fields, L., Doria, A., Orban, T., Saad, M., Warram, J.H., Montminy, M., Krolewski, A.S. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. (1999) Nature Genetics. 23(3):323-8. DOI: 10.1038/15500

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Parker, D., Rivera, M., Zor, T., Henrion-Caude, A., Radhakrishnan, I., Kumar, A., Shapiro, L.H., Wright, P.E., Montminy, M., Brindle, P.K. Role of secondary structure in discrimination between constitutive and inducible activators. (1999) Molecular and Cellular Biology. 19(8):5601-7.

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Radhakrishnan, I., Pérez-Alvarado, G.C., Parker, D., Dyson, H.J., Montminy, M.R., Wright, P.E. Structural analyses of CREB-CBP transcriptional activator-coactivator complexes by NMR spectroscopy: implications for mapping the boundaries of structural domains. (1999) Journal of Molecular Biology. 287(5):859-65. DOI: 10.1006/jmbi.1999.2658

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Du, K., Montminy, M. CREB is a regulatory target for the protein kinase Akt/PKB. (1998) Journal of Biological Chemistry. 273(49):32377-9.

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Parker, D., Jhala, U.S., Radhakrishnan, I., Yaffe, M.B., Reyes, C., Shulman, A.I., Cantley, L.C., Wright, P.E., Montminy, M. Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. (1998) Molecular Cell. 2(3):353-9.

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Dutta, S., Bonner-Weir, S., Montminy, M., Wright, C. Regulatory factor linked to late-onset diabetes? (1998) Nature. 392(6676):560. DOI: 10.1038/33311


Blobel, G.A., Nakajima, T., Eckner, R., Montminy, M., Orkin, S.H. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. (1998) Proceedings of the National Academy of Sciences of the United States of America. 95(5):2061-6.

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Radhakrishnan, I., Pérez-Alvarado, G.C., Parker, D., Dyson, H.J., Montminy, M.R., Wright, P.E. Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions. (1997) Cell. 91(6):741-52.

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Nakajima, T., Uchida, C., Anderson, S.F., Lee, C.G., Hurwitz, J., Parvin, J.D., Montminy, M. RNA helicase A mediates association of CBP with RNA polymerase II. (1997) Cell. 90(6):1107-12.

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Montminy, M. Transcriptional activation. Something new to hang your HAT on. (1997) Nature. 387(6634):654-5. DOI: 10.1038/42594


Montminy, M. Transcriptional regulation by cyclic AMP. (1997) Annual Review of Biochemistry. 66:807-22. DOI: 10.1146/annurev.biochem.66.1.807

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Sharma, S., Jhala, U.S., Johnson, T., Ferreri, K., Leonard, J., Montminy, M. Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1. (1997) Molecular and Cellular Biology. 17(5):2598-604.

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Mayall, T.P., Sheridan, P.L., Montminy, M.R., Jones, K.A. Distinct roles for P-CREB and LEF-1 in TCR alpha enhancer assembly and activation on chromatin templates in vitro. (1997) Genes & Development. 11(7):887-99.

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Nakajima, T., Uchida, C., Anderson, S.F., Parvin, J.D., Montminy, M. Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors. (1997) Genes & Development. 11(6):738-47.

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Chakravarti, D., LaMorte, V.J., Nelson, M.C., Nakajima, T., Schulman, I.G., Juguilon, H., Montminy, M., Evans, R.M. Role of CBP/P300 in nuclear receptor signalling. (1996) Nature. 383(6595):99-103. DOI: 10.1038/383099a0

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Montminy, M., Brindle, P., Arias, J., Ferreri, K., Armstrong, R. Regulation of somatostatin gene transcription by cyclic adenosine monophosphate. (1996) Metab. Clin. Exp. 45(8 Suppl 1):4-7.

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Nakajima, T., Fukamizu, A., Takahashi, J., Gage, F.H., Fisher, T., Blenis, J., Montminy, M.R. The signal-dependent coactivator CBP is a nuclear target for pp90RSK. (1996) Cell. 86(3):465-74.

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Montminy, M., Brindle, P., Arias, J., Ferreri, K., Armstrong, R. Regulation of somatostatin gene transcription by cAMP. (1996) Adv. Pharmacol. 36:1-13.


Kee, B.L., Arias, J., Montminy, M.R. Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator. (1996) Journal of Biological Chemistry. 271(5):2373-5.

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Parker, D., Ferreri, K., Nakajima, T., LaMorte, V.J., Evans, R.M., Koerber, S.C., Hoeger, C., Montminy, M.R. Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism. (1996) Molecular and Cellular Biology. 16(2):694-703.

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Sharma, S., Leonard, J., Lee, S., Chapman, H.D., Leiter, E.H., Montminy, M.R. Pancreatic islet expression of the homeobox factor STF-1 relies on an E-box motif that binds USF. (1996) Journal of Biological Chemistry. 271(4):2294-9.

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Peers, B., Sharma, S., Johnson, T., Kamps, M., Montminy, M. The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain. (1995) Molecular and Cellular Biology. 15(12):7091-7.

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Brindle, P., Nakajima, T., Montminy, M. Multiple protein kinase A-regulated events are required for transcriptional induction by cAMP. (1995) Proceedings of the National Academy of Sciences of the United States of America. 92(23):10521-5.

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Bertherat, J., Chanson, P., Montminy, M. The cyclic adenosine 3',5'-monophosphate-responsive factor CREB is constitutively activated in human somatotroph adenomas. (1995) Molecular Endocrinology. 9(7):777-83. DOI: 10.1210/mend.9.7.7476961

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Montminy, M., Brindle, P., Arias, J., Ferreri, K., Armstrong, R. Regulation of somatostatin gene transcription by cAMP. (1995) Ciba Found. Symp. 190:7-20; discussion 20-5.

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Armstrong, R., Wen, W., Meinkoth, J., Taylor, S., Montminy, M. A refractory phase in cyclic AMP-responsive transcription requires down regulation of protein kinase A. (1995) Molecular and Cellular Biology. 15(3):1826-32.

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Guz, Y., Montminy, M.R., Stein, R., Leonard, J., Gamer, L.W., Wright, C.V., Teitelman, G. Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. (1995) Development. 121(1):11-8.

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Peers, B., Leonard, J., Sharma, S., Teitelman, G., Montminy, M.R. Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. (1994) Molecular Endocrinology. 8(12):1798-806. DOI: 10.1210/mend.8.12.7708065

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Arias, J., Alberts, A.S., Brindle, P., Claret, F.X., Smeal, T., Karin, M., Feramisco, J., Montminy, M. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. (1994) Nature. 370(6486):226-9. DOI: 10.1038/370226a0

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Alberts, A.S., Montminy, M., Shenolikar, S., Feramisco, J.R. Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts. (1994) Molecular and Cellular Biology. 14(7):4398-407.

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Alberts, A.S., Arias, J., Hagiwara, M., Montminy, M.R., Feramisco, J.R. Recombinant cyclic AMP response element binding protein (CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei. (1994) Journal of Biological Chemistry. 269(10):7623-30.

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Ferreri, K., Gill, G., Montminy, M. The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complex. (1994) Proceedings of the National Academy of Sciences of the United States of America. 91(4):1210-3.

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Meinkoth, J.L., Alberts, A.S., Went, W., Fantozzi, D., Taylor, S.S., Hagiwara, M., Montminy, M., Feramisco, J.R. Signal transduction through the cAMP-dependent protein kinase. (1993) Molecular and Cellular Biochemistry. 127-128:179-86.

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Chrivia, J.C., Kwok, R.P., Lamb, N., Hagiwara, M., Montminy, M.R., Goodman, R.H. Phosphorylated CREB binds specifically to the nuclear protein CBP. (1993) Nature. 365(6449):855-9. DOI: 10.1038/365855a0

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Leonard, J., Peers, B., Johnson, T., Ferreri, K., Lee, S., Montminy, M.R. Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. (1993) Molecular Endocrinology. 7(10):1275-83. DOI: 10.1210/mend.7.10.7505393

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Montminy, M. Trying on a new pair of SH2s. (1993) Science. 261(5129):1694-5.


Brindle, P., Linke, S., Montminy, M. Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors. (1993) Nature. 364(6440):821-4. DOI: 10.1038/364821a0

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Hagiwara, M., Brindle, P., Harootunian, A., Armstrong, R., Rivier, J., Vale, W., Tsien, R., Montminy, M.R. Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. (1993) Molecular and Cellular Biology. 13(8):4852-9.

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Montminy, M. Cell differentiation. The road not taken. (1993) Nature. 364(6434):190-1. DOI: 10.1038/364190a0


Armstrong, R.C., Montminy, M.R. Transsynaptic control of gene expression. (1993) Annual Review of Neuroscience. 16:17-29. DOI: 10.1146/annurev.ne.16.030193.000313


Leonard, J., Serup, P., Gonzalez, G., Edlund, T., Montminy, M. The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells. (1992) Proceedings of the National Academy of Sciences of the United States of America. 89(14):6247-51.

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Hagiwara, M., Alberts, A., Brindle, P., Meinkoth, J., Feramisco, J., Deng, T., Karin, M., Shenolikar, S., Montminy, M. Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. (1992) Cell. 70(1):105-13.

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Brindle, P.K., Montminy, M.R. The CREB family of transcription activators. (1992) Current Opinion in Genetics & Development. 2(2):199-204.

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Leonard, J., Montminy, M.R. Control of gene expression by transmitters and peptide hormones. (1991) Current Opinion in Neurobiology. 1(1):74-8.


Struthers, R.S., Vale, W.W., Arias, C., Sawchenko, P.E., Montminy, M.R. Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant. (1991) Nature. 350(6319):622-4. DOI: 10.1038/350622a0

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Gonzalez, G.A., Menzel, P., Leonard, J., Fischer, W.H., Montminy, M.R. Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB. (1991) Molecular and Cellular Biology. 11(3):1306-12.

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Meinkoth, J.L., Montminy, M.R., Fink, J.S., Feramisco, J.R. Induction of a cyclic AMP-responsive gene in living cells requires the nuclear factor CREB. (1991) Molecular and Cellular Biology. 11(3):1759-64.

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Montminy, M.R., Gonzalez, G.A., Yamamoto, K.K. Characteristics of the cAMP response unit. (1990) Metab. Clin. Exp. 39(9 Suppl 2):6-12.

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Lamph, W.W., Dwarki, V.J., Ofir, R., Montminy, M., Verma, I.M. Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation. (1990) Proceedings of the National Academy of Sciences of the United States of America. 87(11):4320-4.

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Montminy, M.R., Gonzalez, G.A., Yamamoto, K.K. Regulation of cAMP-inducible genes by CREB. (1990) Trends in Neurosciences. 13(5):184-8.

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Yamamoto, K.K., Gonzalez, G.A., Menzel, P., Rivier, J., Montminy, M.R. Characterization of a bipartite activator domain in transcription factor CREB. (1990) Cell. 60(4):611-7.

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Montminy, M.R., Gonzalez, G.A., Yamamoto, K.K. Characteristics of the cAMP response unit. (1990) Recent Prog. Horm. Res. 46:219-29; discussion 29-30.


Dwarki, V.J., Montminy, M., Verma, I.M. Both the basic region and the 'leucine zipper' domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation. (1990) EMBO Journal. 9(1):225-32.

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Gonzalez, G.A., Montminy, M.R. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. (1989) Cell. 59(4):675-80.

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Gonzalez, G.A., Yamamoto, K.K., Fischer, W.H., Karr, D., Menzel, P., Biggs, W., Vale, W.W., Montminy, M.R. A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence. (1989) Nature. 337(6209):749-52. DOI: 10.1038/337749a0

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Montminy, M.R. Regulation of eukaryotic genes by cyclic-AMP. (1988) Nihon Naibunpi Gakkai Zasshi. 64(12):1233-5.


Yamamoto, K.K., Gonzalez, G.A., Biggs, W.H., Montminy, M.R. Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. (1988) Nature. 334(6182):494-8. DOI: 10.1038/334494a0

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Montminy, M.R., Bilezikjian, L.M. Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene. (1987) Nature. 328(6126):175-8. DOI: 10.1038/328175a0

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Höfler, H., Childers, H., Montminy, M.R., Goodman, R.H., Lechan, R.M., DeLellis, R.A., Tischler, A.S., Wolfe, H.J. Localization of somatostatin mRNA in the gut, pancreas and thyroid gland of the rat using antisense RNA probes for in situ hybridization. (1987) Acta Histochemica. 34:101-5.

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Sevarino, K.A., Felix, R., Banks, C.M., Low, M.J., Montminy, M.R., Mandel, G., Goodman, R.H. Cell-specific processing of preprosomatostatin in cultured neuroendocrine cells. (1987) Journal of Biological Chemistry. 262(11):4987-93.

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Goodman, R.H., Leiter, A., Low, M.J., Montminy, M.R., Tsukada, T., Fink, J.S., Mandel, G. Biosynthesis of pancreatic islet hormones. (1987) Hepatology. 7(1 Suppl):36S-41S.

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Hoefler, H., Childers, H., Montminy, M.R., Lechan, R.M., Goodman, R.H., Wolfe, H.J. In situ hybridization methods for the detection of somatostatin mRNA in tissue sections using antisense RNA probes. (1986) Histochem. J. 18(11-12):597-604.

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Montminy, M.R., Sevarino, K.A., Wagner, J.A., Mandel, G., Goodman, R.H. Identification of a cyclic-AMP-responsive element within the rat somatostatin gene. (1986) Proceedings of the National Academy of Sciences of the United States of America. 83(18):6682-6.

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Montminy, M.R., Low, M.J., Tapia-Arancibia, L., Reichlin, S., Mandel, G., Goodman, R.H. Cyclic AMP regulates somatostatin mRNA accumulation in primary diencephalic cultures and in transfected fibroblast cells. (1986) Journal of Neuroscience. 6(4):1171-6.

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Leiter, A.B., Montminy, M.R., Jamieson, E., Goodman, R.H. Exons of the human pancreatic polypeptide gene define functional domains of the precursor. (1985) Journal of Biological Chemistry. 260(24):13013-7.

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Tsukada, T., Horovitch, S.J., Montminy, M.R., Mandel, G., Goodman, R.H. Structure of the human vasoactive intestinal polypeptide gene. (1985) DNA. 4(4):293-300. DOI: 10.1089/dna.1985.4.293

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Goodman, R.H., Montminy, M.R., Low, M.J., Habener, J.F. Biosynthesis of rat preprosomatostatin. (1985) Advances in Experimental Medicine and Biology. 188:31-47.

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Montminy, M.R., Goodman, R.H., Horovitch, S.J., Habener, J.F. Primary structure of the gene encoding rat preprosomatostatin. (1984) Proceedings of the National Academy of Sciences of the United States of America. 81(11):3337-40.

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Lund, P.K., Goodman, R.H., Montminy, M.R., Dee, P.C., Habener, J.F. Anglerfish islet pre-proglucagon II. Nucleotide and corresponding amino acid sequence of the cDNA. (1983) Journal of Biological Chemistry. 258(5):3280-4.


Montminy, M., Teres, D. Shock after phenothiazine administration in a pregnant patient with a pheochromocytoma. A case report and literature review. (1983) J Reprod Med. 28(2):159-62.

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Education

BS, Biochemistry, Harvard University
MD, PhD, Physiology, Tufts University School of Medicine
Research Fellow in Medicine, Tufts-New England Medical Center, Boston


Awards & Honors

  • 2009 National Academy of Sciences
  • 1991 McKnight Neuroscience Development Award
  • 1990 Richard E. Weitzman Award, Endocrine Society