Publications -Belmonte - Salk Institute for Biological Studies

List of Publications

2017

400. The Ground Rules of Pluripotency Regulatory Networks
Li, M. and Izpisua Belmonte, J.C.
Nature Reviews Genetics (2017) ePub Ahead of Print Jan 3.

401. Interspecies chimerism with human pluripotent stem cells
Wu, J., Platero Luengo, A., Sakurai, M., Sugawara, A., Gil, M.A., Yamauchi, T., Suzuki, K., Soledad Bogliotti, Y., Cuello, C., Morales Valencia, M., Okamura, D., Luo, J., Vilarino, M., Parrilla, I., Soto, D., Martinez, C.A., Hishida, T., Martinez, L., Sanchez, S., Wang, H., Nohalez, A., Suzuki, E., Martinez-Redondo, P., Ocampo, A., Reddy, P., Roca, J., Maga, E.A., Rodriguez Esteban, C., Berggren, W.T., Nuñez, E., Lajara, J., Guillen, I., Guillen, P., Campistol, J.M., Martinez, E.A., Ross, P.J. and Izpisua Belmonte, J.C.
Cell (2017) 168(3):473-486.e15.

402. Non-coding microRNAs for cardiac regeneration: exploring novel alternatives inducing heart healing
Garreta, E., Pardo, P., Izpisua Belmonte, J.C. and Montserrat, N.
Non-coding RNA Research (2017) In Press.

403. Developmental Competence of Porcine Genome Edited Zygotes
Gil, M.A., Martinez, C.A., Nohalez, A., Parrilla, I., Roca, J., Wu, J., Ross, P.J., Cuello, C., Izpisua, J.C. and Martinez, E.A.
Molecular Reproduction and Development (2017) In Press.

404. CRISPR/Cas9-mediated Targeted Gene Correction in Amyotrophic Lateral Sclerosis Patient iPSCs
Wang, L., Yi, F., Fu, L., Yang, J., Wang, S., Wang, Z., Suzuki, K., Qiao, J., Izpisua Belmonte, J.C., Yang, Z., Yuan, Y., Qu, J. and Liu, G.-H.
Protein and Cell (2017) In Press.

405. Expressional analysis of transcription factors expressed in the anterior side of limb buds.
Yokoyama, S., Furukawa, S., Kitada, S., Mori, M., Saito, T., Kawakami, K., Izpisua Belmonte, J.C., Kawakami, Y., Ito, Y., Sato, T. and Asahara, H.
PLoS ONE (2017) In Press.

406. Aberrant iPSC methylation is associated with motif enrichment and gene expression changes in a clone-specific manner independent of genetics.
Panopoulos, A., Smith, E.N., Arias, A.D., Shepard, P.J., Hishida, Y., Modesto, V., Diffenderfer, K.E., Conner, C., Biggs, W., Sandoval, E., D’Antonio-Chronowska, A., Berggren, W.T., Izpisua Belmonte, J.C. and Frazer, K.
Cell Stem Cell (2017) In Press.

407. iPSCORE: A systematically derived resource of iPSC lines from 222 individuals for use in examining how genetic variation affects molecular and physiological traits across a variety of cell types
Panopoulos, A.D., D’Antonio, M., Benaglio, P., Williams, R., Hashem, S., Schuldt, B.M., DeBoever, C., Arias, A.D., Garcia, M., Nelson, B., Harismendy, O., Grinstein, J.D., Drees, F., Okubo, J., Diffenderfer, K.E., Hishida, Y., Modesto, V., Dargitz, C.T., Feiring, R., Zhao, C., McGarry, T.J., Matsui, H., Reyna, J., Aguirre, A., Rao, F., O’Connor, D.T., Yeo, G.W., Evans, S.M., Chi, N.C., Jepsen, K., Nariai, N., Muller, F.-J., Goldstein, L.S.B., Izpisua Belmonte, J.C., Adler, E., Loring, J.F., Berggren, W.T., D’Antonio-Chronowska, A., Smith, E.N. and Frazer, K.A.
Stem Cell Reports (2017) In Press.

408. Targeted CpG island methylation in human pluripotent stem cells
Takahashi, Y., Suzuki, K., Martinez Redondo, P., Wu, J., Li, M., Liao, H.-K., Wu, M.-Z., Hishida, T., Nikolaievich Shokhirev, M., Rodriguez Esteban, C., Sancho-Martinez, I. and Izpisua Belmonte, J.C.
Science (2017) In Press

409. Human and Mouse Stem Cells with Embryonic and Extraembryonic Developmental Potency
Yang, Y., Liu, B., Xu, J., Wang, J., Wu, J., Shi, C., Xu, Y., Dong, J., Sun, F., Wang, C., Lai, W., Zhu, J., Xiong, L., Yang, W., Yamauchi, T., Sugawara, A., Li, Z., Chi, X., Zhang, H., Li, X., Yin, M., Zhu, D., Shen, H., Izpisua Belmonte, J.C. and Deng, H.
Cell (2017) In Press

2016

378. Regenerative strategies for kidney engineering
Montserrat, N., Garreta, E. and Izpisua Belmonte, J.C.
FEBS Journal (2016) ePub ahead of print. [link]

379. The XEN of Reprogramming
Beyret, E. and Izpisua Belmonte, J.C.
Cell Research (2016) 26(2):147-8. [link]

380. Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs
Fu, L., Xu, X., Ren, R., Wu, J., Zhang, W., Yang, J., Ren, X., Wang, S., Zhao, Y., Sun, L., Yu, Y., Wang, Z., Yang, Z., Yuan, Y., Qiao, J., Izpisua Belmonte, J.C., Qu, J. and Liu, G.
Protein Cell (2016) Epub ahead of print Feb. 13 [link]

381. Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells
Suzuki, A., Hirasaki, M., Hishida, T., Wu, D., Okamura, D., Ueda, A., Nishimoto, M., Nakachi, Y., Mizuno, Y., Okazaki, Y., Matsui, Y., Izpisua Belmonte, J.C. and Okuda, A.
Nature Communications (2016) In Press.

382. The Molecular Harbingers of Early Mammalian Embryo Patterning
Wu, J. and Izpisua Belmonte, J.C.
Cell (2016) 165:13-15.

383. An Overview of Mammalian Pluripotency
Wu, J., Yamauchi, T. and Izpisua Belmonte, J.C.
Development (2016) 143:1644-8.

384. Garreta, E., de Oñate, L., Fernandez-Santos, M.E., Oria Fernandez, R., Tarantino, C., Climent, A., Marco, A., Samitier, M., Martinez, E., Valls-Margarit, M., Matasanz, R., Taylor, D.A., Fernandez Aviles, F., Izpisua Belmonte, J.C. and Montserrat, N.
Myocardial Commitment from Human Pluripotent Stem Cells: Rapid Production of Human Heart Grafts
Journal of Biomaterials (2016) 98:64-78.

385. Eguizabal, C., Herrera, L., de Oñate, L., Montserrat, N., Hajkova, P. and Izpisua Belmonte, J.C.
Epigenetic Changes Characterization During Human Gonadal Primordial Germ Cells Reprogramming
Stem Cells (2016) Jun 14 Epub Ahead of Print.

386. Li, M. and Izpisua Belmonte, J.C.
Looking to the future following 10 years of induced pluripotent stem cell technologies
Nature Protocols (2016) 11:1579-85.

387. Sancho-Martinez, I. and Izpisua Belmonte, J.C.
Reprogramming strategies for the establishment of novel human cancer models
Cell Cycle (2016) Jun Epub Ahead of Print.

388. Stem cells: a renaissance in human biology research
Wu, J. and Izpisua Belmonte, J.C.
Cell (2016) 165:1572-85.

389. Anti-aging strategies based on cellular reprogramming
Ocampo, A., Reddy, P. and Izpisua Belmonte, J.C.
Trends in Molecular Medicine (2016) 22:725-38.

390. Cellular Metabolism and Induced Pluripotency
Wu, J., Ocampo, A. and Izpisua Belmonte, J.C.
Cell (2016) 166:1371–1385.

391. 3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors
Li, Z., Araoka, T., Wu, J., Liao, H.-K., Li, M., Lazo, M., Zhou, B., Sui, Y., Wu, M.-Z., Tamura, I., Xia, Y., Beyret, E., Matsusaka, T., Pastan, I., Rodriguez Esteban, C., Guillen, I., Guillen, P., Campistol, J.M. and Izpsiua Belmonte, J.C.
Cell Stem Cell (2016) S1934-5909(16)30211-9.

392. Anti-aging strategies based on cellular reprogramming
Wu, J., Platero Luengo, A., Gil, M.A., Suzuki, K., Cuello, C., Morales Valencia, M., Parrilla, I., Martinez, C.A., Nohalez, A., Roca, J., Martinez, E.A. and Izpisua Belmonte, J.C.
Reproduction in Domestic Animals (2016) 51 Suppl 2:18-24.

393. Stem Cells and Interspecies Chimeras
Wu, J., Greely, H.T., Jaenisch, R., Nakauchi, H., Rossant, J., and Izpisua Belmonte, J.C.
Nature (2016) 540:51-59.

394. Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations.
Kang, E., Wu, J., Marti Gutierrez, N., Koski, A., Tippner-Hedges, R., Agaronyan, K., Platero Luengo, A., Martinez Redondo, P., Ma, H., Lee, Y., Hayama, T., Van Dyken, C., Wang, X., Luo, S., Ahmed, R., Li, Y., Ji, D., Kayali, R., Cinnigolu, C., Olson, S., Jensen, J., Battaglia, D., Lee, D., Wu, D., Wolf, D.P., Huang, T., Dmitry, T., Izpisua Belmonte, J.C., Amato, P. and Mitalipov, S.
Nature (2016) 540(7632):270-275.

395. In vivo genome editing via CRISPR-Cas9 mediated homology-independent targeted integration
Suzuki, K., Tsunekawa, Y., Hernandez-Benitez, R., Wu, J., Zhu, J., Kim, E., Hatanaka, F., Yamamoto, M., Araoka, T., Li, Z., Kurita, M., Hishida, T., Li, M., Aizawa, E., Chen, S., Goebl, A., Soligalla, R.D., Qu, J., Jiang, T., Skowronska-Krawczyk, D., Rodriguez Esteban, C., Lajara, J., Nuñez, E., Guillen, P., Campistol, J.M., Matsuzaki, F., Liu, G.-H., Magistretti, P., Zhang, K., Callaway, E., Zhang, K and Izpisua Belmonte, J.C.
Nature (2016) 540(7631):144-149.

396. Systems biology analysis reveals role of MDM2 in diabetic nephropathy
Saito, R., Rocanin-Arjo, A., You, Y.-H., Darshi, M., Van Espen, B., Pu, M., Romoli, S., Natarajan, L., Ju, W., Kretzler, M., Nelson, R., Ono, K., Thomasova, D., Mulay, S., Ideker, T., Izpisua Belmonte, J.C., Anders, H.J. and Sharma, K.
Journal of Clinical Investigation (2016) 1(17):e87877.

397. Human Organs from Animal Bodies
Izpisua Belmonte, J.C.
Scientific American (2016) 315(5):32-37.

398. Genome editing in human pluripotent stem cells: a systematic approach unrevealing pancreas development and disease.
Garreta, E., Marco, A., Izpisua Belmonte, J.C. and Montserrat, N.
Stem Cell Investigation (2016) 14;3:76.

399. In vivo amelioration of aging hallmarks by partial reprogramming
Ocampo, A., Reddy, P., Martinez-Redondo, P., Platero-Luengo, A., Hatanaka, F., Hishida, T., Li, M., Lam, D., Kurita, M., Beyret, E., Araoka, T., Vazquez-Ferrer, E., Donoso, D., Roman, J.L., Xu, J., Rodriguez Esteban, C., Nuñez, G., Nuñez-Delicado, E., Campistol, J.M., Guillen, I., Guillen, P. and Izpisua Belmonte, J.C.
Cell (2016) 167(7):1719-1733.e12.

2015

353. Roles for noncoding RNAs in cell-fate determination and regeneration
Li, M., and Izpisua Belmonte, J.C.
Nature Structural & Molecular Biology, (2015) 22, 2-4. [link]

354. Efficient delivery and functional expression of transfected modified mRNA in human embryonic stem cell-derived retinal pigmented epithelial cells
Hansson, M. L., Albert, S., Somermeyer, L. G., Peco, R., Mejía-Ramirez, E., Montserrat, N., and Izpisua Belmonte, J.C.
Journal of Biological Chemistry (2015) 290(9):5661-72. [link]

355. Stem cells. Holding your breath for longevity
Ocampo, A. and Izpisua Belmonte, J.C.
Science (2015) 347(6228):1319-20. [link]

356. Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells
Liao, H.-K., Gu, Y., Diaz, A., Marlett, J., Takahashi, Y., Li, M., Suzuki, K., Xu, R., Hishida, T., Chang, C.-J., Young, J., and Izpisua Belmonte, J.C.
Nature Communications (2015) 10;6:6413. [link]

357. Identification of novel long noncoding RNAs underlying vertebrate cardiovascular development
Kurian, L., Aguirre, A., Sancho-Martinez, I., Benner, C., Hishida, T., Nguyen, T.B., Reddy, P., Nivet, E., Krause, M.N., Nelles, D.A., Rodriguez Esteban, C., Campistol, J., Yeo, G.W. and Izpisua Belmonte, J.C.
Circulation (2015) 131(14):1278-90. [link]

358. Brief Report: Oxidative Stress Mediates Cardiomyocyte Apoptosis in a Human Model of Danon Disease and Heart Failure
Hashem, S.I., Perry, C.N., Bauer, M., Han, S., Clegg, S.D., Ouyang, K., Deacon, D.C., Spinharney, M., Panopoulos, A.D., Izpisua Belmonte, J.C., Frazer, K.A., Chen, J., Gong, Q., Zhou, Z., Chi, N.C., Adler, E.D.
Stem Cells (2015) 33(7):2343-50. [link]

359. Brains, genes and primates
Izpisua Belmonte, J.C., Callaway, E.M., Churchland, P., Caddick, S.J., Feng, G., Homanics, G.E., Lee, K-F, Leopold, D.A., Miller, C.T., Mitchell, J.F., Mitalipov, S., Muotri, A.R., Movshon, J.A., Okano, H., Reynolds, J.H., Ringach, D., Sejnowski, T.J., Silva, A.C., Strick, P.L., Wu, J. and Zhang, F.
Neuron (2015) 86:617-631. [link]

360. An alternative pluripotent state confers interspecies chimaeric competency
Wu, J., Okamura, D., Li, M., Suzuki, K., Luo, C., Ma, L., He, Y., Li, Z., Benner, C., Tamura, I., Krause, M.N., Nery, J.R., Du, T., Zhang, Z., Hishida, T., Takahashi, Y., Aizawa, E., Kim, N.Y., Lajara, J., Guillen, P., Campistol, J.M., Rodriguez Esteban, C., Ross, P., Saghatelian, A., Ren, B., Ecker, J. and Izpisua Belmonte, J.C. (2015)
Nature (2015) 521:316-321. [link]

361. Selective elimination of mitochondrial mutations in the germline by genome editing
Reddy, P., Ocampo, A., Suzuki, K., Luo, J., Bacman, S.R., Williams, S.L., Sugawara, A., Okamura, D., Tsunekawa, Y., Wu, J., Lam, D., Xiong, X., Montserrat, N., Rodriguez Esteban, C., Liu, G.-H., Sancho-Martinez, I., Manau, D., Civico, S., Cardellach, F., del Mar O’Callaghan, M., Campistol, J., Zhao, H., Campistol, J.M., Moraes, C.T. and Izpisua Belmonte, J.C.
Cell (2015) 161: 459-469. [link]

362. Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
Zhang, W., Li, J., Suzuki, K., Qu, J., Wang, P., Zhou, J., Liu, X., Ren, R., Xu, X., Ocampo, A., Yuan, T., Yang, J., Li, Y., Shi, L., Guan, D., Pan, H., Duan, S., Ding, Z., Li, M., Yi, F., Bai, R., Wang, Y., Chen, C., Yang, F., Li, X., Wang, Z., Aizawa, E., Goebl, A., Soligalla, R.D., Reddy, P., Rodriguez Esteban, C., Tang, F., Liu, G.-H. and Izpisua Belmonte, J.C.
Science (2015) 348(6239):1160-3. [link]

363. Metabolic Rescue in Pluripotent Cells from Patients with mtDNA Disease
Ma, H., Folmes, C. D.L., Wu, J., Morey, R., Mora-Castilla, S., Ocampo, A., Ma, L., Poulton, J., Wang, X., Ahmed, R., Kang, E., Lee, Y., Hayama, T., Li, Y., Van Dyken, C., Gutierrez, N. M., Tippner-Hedges, R., Koski, A., Mitalipov, N., Amato, P., Wolf, D.P., Huang, T., Terzic, A., Laurent, L., Izpisua Belmonte, J.C. and Mitalipov, S. (2015)
Nature (2015) 524:234-238. [link]

364. Regenerative medicine: targeted genome editing in vivo
Wang, L., Wu, J., Fang, W., Liu, G.-H., and Izpisua Belmonte, J.C.
Cell Research (2015) 25(3):271-2. [link]

365. Stem cell, CRISPR and HIV
Liao, H.K., Li, M., Martinez Martinez, L. and Izpisua Belmonte, J.C.
Cell Cycle (2015) 14:13, 1-2 [link]

366. Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders
Feron, F., Gepner, B., Lacassagne, E., Stephan, D., Mesnage, B., Blanchard, M.-P., Boulanger, N., Tardif, C., Deveze, A., Rousseau, S., Suzuki, K., Izpisua Belmonte, J.C., Khrestchatisky, M, Nivet, E. and Erard Garcia, M.
Molecular Psychiatry (2015) August 4 Epub Ahead of Print. [link]

367. Betaglycan knock-down causes embryonic angiogenesis defects in zebrafish
Kamaid, A., Molina-Villa, T., Mendoza, V., Pujades, C., Maldonado, E., Izpisua Belmonte, J.C. and Lopez-Casillas, F.
The Journal of Genetics and Development (2015) 53: 583–603. [link]

368. Hypoxia drives breast tumor malignancy through a TET-TNFa-p38-MAPK signalling axis
Wu, M.-Z., Chen, S.-F., Nieh, S., Benner, C., Ger, L.-P., Jan, C.-I., Ma, L., Chen, C.-H., Hishida, T., Chang, H.-T., Lin, Y.-S., Montserrat, N., Gascon, P., Sancho-Martinez, I., and Izpisua Belmonte, J.C.
Cancer Research (2015) 75(18):3912-24. [link]

369. Functional compensation between Myc and PI3K signaling supports self-renewal of embryonic stem cells
Hishida T, Nakachi Y, Mizuno Y, Katano M, Okazaki Y, Ema M, Takahashi S, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Hishida-Nozaki Y, Vazquez-Ferrer E, Sancho-Martinez I, Izpisua Belmonte JC, Okuda A.
Stem Cells (2015) 33(3):713-25. [link]

370. Creating Patient-specific Neural Cells for the In Vitro Study of Brain Disorders
Brennand, K., Marchetto, M. C., Benvenisty, N., Brustle, O., Ebert, A., Izpisua Belmonte, J. C., Kaykas, A., Lancaster, M., Livesey, R., McConnell, M., McKay, R., Morrow, E., Muotri, A., Panchision, D. M., Rubin, L. L., Sawa, A., Soldner, F., Song, H., Studer, L., Temple, S., Vaccarino, F., Wu, J., Vanderhaeghen, P., Gage, F. H., Jaenisch, R.
Stem Cell Reports (2015) 5(6):933-45. [link]

371. Activin A/BMP2 chimera AB235 drives efficient redifferentiation of long term cultured autologous chondrocytes
Jimenez, G., Lopez Ruiz, E., Kwiatkowski, W., Montanez, E., Arrebola, F., Carrillo, E., Gray, P., Izpisua Belmonte, J.C., Choe, S., Peran, M. and Marchal, J.A.
Scientific Reports (2015) 5:16400. [link]

372. Metabolic exit from naive pluripotency
Wu, J. and Izpisua Belmonte, J.C.
Nature Cell Biology (2015) 17(12):1519-21. [link]

373. Dynamic Pluripotent Stem Cell States and Their Applications
Wu, J. and Izpisua Belmonte, J.C.
Cell Stem Cell (2015) 17:509-525. [link]

374. PTEN deficiency reprograms human neural stem cells towards a glioblastoma stem cell-like phenotype
Duan, S., Yuan, G., Liu, X., Ren, R., Li, J., Zhang, W., Wu, J., Xu, X., Fu, L., Li, Y., Yang, J., Zhang, W., Bai, R., Yi, F., Suzuki, K., Gao, H., Rodriguez Esteban, C., Zhang, C., Izpisua Belmonte, J.C., Chen, Z., Wang, X., Jiang, T., Qu, J., Tang, F. and Liu, G.-H.
Nature Communications (2015) 6:10068. [link]

375. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells
Sancho-Martinez, I., Nivet, E., Xia, Y., Hishida, T., Aguirre, A., Ocampo, A., Ma, L., Morey, R., Krause, M.N., Zembrzycki, A., Ansorge, O., Vazquez-Ferrer, E., Dubova, I., Reddy, P., Lam, D., Hishida, Y., Wu, M.-Z., Rodriguez Esteban, C., O’Leary, D., Wahl, G.M., Verma, I. M., Laurent, L. C. and Izpisua Belmonte, J.C.
Nature Communications (2015) 7:10743. [link]

376. Mending a Faltering Heart
Li, M. and Izpisua Belmonte, J.C.
Circulation Research (2015) 118(2):344-51. [link]

377. Understanding the molecular mechanisms of reprogramming
Krause, M.N., Sancho-Martinez, I and Izpisua Belmonte, J.C.
BBRC (2015) pii: S0006-291X(15)30989-X. [link]

2014

330. Generation of iPSCs from Genetically Corrected Brca2 Hypomorphic Cells: Implications in Cell Reprogramming and Stem Cell Therapy
Navarro, S., Moleiro, V., Molina-Estevez, F.J., Lozano, M.L., Chinchon, R., Almarza, E., Quintana-Bustamante, O., Mostoslavsky, G., Maetzig, T., Galla, M., Heinz, N., Schiedlmeier, B., Torres, Y., Modlich, U., Samper, E., Segovia, J.C., Raya, A., Güenechea, G., Izpisua Belmonte, J.C., and Bueren, J.A.
Stem Cells (2014) 32(2):436-46. [link]

331. Regenerative medicine: Transdifferentiation in vivo
Fu, L., Zhu, X., Yi, F., Liu, G.-H. and Izpisua Belmonte, J.C.
Cell Research (2014) 24:141-142. [link]

332. The Lysine-Specific Demethylase 1 is a novel substrate of protein kinase CK2
Costa, R., Arrigoni, G., Cozza, G., Lolli, G., Battistutta, R., Izpisua Belmonte, J.C., Pinna, L.A. and Sarno, S.
BBAPAP (2014) 1844:722-9. [link]

333. Ageing: Genetic rejuvenation of old muscle
Li, M. and Izpisua Belmonte, J.C.
Nature (2014) 506 (7488):304-5. [link]

334. Designer nodal/BMP2 chimeras mimic nodal signaling, promote chondrogenesis, and reveal a BMP2-like structure
Esquivies, L., Blackler, A., Peran, M., Rodriguez-Esteban, C., Izpisua Belmonte, J.C., Booker, E., Gray, P.C., Ahn, C., Kwiatkowski, W. and Choe, S.
Journal of Biological Chemistry. (2014) 289(3):1788-97. [link]

335. Direct reprogramming of porcine fibroblasts to neural progenitors
Xu, X.-L., Yang, J.-P., Fu, L.-N., Ren, R.-T., Yi, F., Suzuki, K., Liu, K., Ding, Z.-C., Qu, J., Zhang, W.-Q., Li, Y., Yuan, T.-T., Yuan, G.-H., Sui, L.-N., Guan, D., Duan, S.-L., Pan, H.-Z., Wang, P., Zhu, X.-P., Montserrat, N., Li, M., Bai, R.-J., Liu, L., Izpisua Belmonte, J.C. and Liu, G.-H.
Protein & Cell. (2014) 5:4-7. [link]

336. Re: Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer
Masuda, S. and Izpisua Belmonte, J.C.
Journal of the National Cancer Institute (2014) 106(3):djt457. [link]

337. Mathematical approaches to modeling development and reprogramming
Morris, R., Sancho-Martinez, I., Sharpee, T.O. and Izpisua Belmonte, J.C.
PNAS (2014) 111(14):5076-82. [link]

338. A chemical approach to “rewire” neural progenitor cells
Wu, M.-Z., Li, M., Liu, G.-H. and Izpisua Belmonte, J.C.
Cell Research. (2014) 24(6):641-2. [link]

339. New strategies in kidney regeneration and tissue engineering
Uzarski, J.S., Xia, Y., Izpisua Belmonte, J.C. and Wertheim, J.A.
Current Opinion in Nephrology and Hypertension (2014) 23(4):399-405. [link]

340. A Novel Suppressive Effect of Alcohol Dehydrogenase 5 in Neuronal Differentiation
Wu, K., Ren, R., Su, W., Wen, B., Zhang, Y., Yi, F., Qiao, X., Yuan, T., Wang, J., Liu, L., Izpisua Belmonte, J.C., Liu, G.-H. and Chen, C.
Journal of Biological Chemistry. (2014). ePub Ahead of Print. [link]

341. Conversion of human fibroblasts into monocyte-like progenitor cells
Pulecio, J., Nivet, E., Sancho-Martinez, I., Vitaloni, M., Guenechea, G., Xia, Y., Kurian, L., Dubova, I., Bueren, J., Laricchia-Robbio, L. and Izpisua Belmonte, J.C.
Stem Cells. (2014) [link]

342. Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs
Liu, G.-H., Suzuki, K., Li, M., Qu, J., Montserrat, N., Tarantino, C., Gu, Y., Yi, F., Xu, X., Zhang, W., Ruiz, S., Plongthonglum, N., Zhang, K., Masuda, S., Nivet, E., Tsunekawa, Y., Soligalia, R.D., Goebl, A., Aizawa, E., Kim, N.Y., Kim, J., Dubova, I., Li, Y., Ren, R., Benner, C., del Sol, A., Bueren, J., Trujillo, J.P., Surralles, J., Cappelli, E., Dufour, C., Rodriguez Esteban, C. and Izpisua Belmonte, J.C. Nature Communications. (2014) [link]

343. Targeted gene correction in human disease-specific induced pluripotent stem cells minimally impacts whole-genome mutational load
Suzuki, K., Yu, C., Qu, J., Li, M., Yao, X., Yuan, T., Goebl, A., Tang, S., Ren, R., Aizawa, E., Zhang, F., Xu, X., Soligalia, R.D., Chen, F., Kim, J., Kim, N.Y., Liao, H.-K., Benner, C., Rodriguez Esteban, C., Kin, Y., Liu, G.-H., Li, Y. and Izpisua Belmonte, J.C.
Cell Stem Cell. (2014) 15:31-36. [link]

344. Regeneration: making muscle from hPSCs
Zhu, X., Fu, L., Yi, F., Liu, G.-H., Ocampo, A., Qu, J. and Izpisua Belmonte, J.C.
Cell Research. (2014) 24:1159-1161. [link]

345. A recipe for targeted therapy in prostate cancer
Masuda, S. and Izpisua Belmonte, J.C.
Nature Reviews Urology. (2014) published online 1 July 2014. [link]

346. Worming towards transdifferentiation, one (Epigenetic) step at a time
Beyret, E. and Izpisua Belmonte, J.C.
Developmental Cell. 30:641-642. [link]

347. Re: Stem Cells Loaded with Multimechanistic Oncolytic Herpes Simplex Virus Variants for Brain Tumor Therapy
Krause, M., Sancho-Martinez, I. and Izpisua Belmonte, J.C.
Journal of the National Cancer Institute. (2014) [link].

348. Reprogramming by lineage specifiers: Blurring the lines between pluripotency and differentiation
Sancho-Martinez, I., Ocampo, A. and Izpisua Belmonte, J.C.
Current Opinion in Genetics and Development. (2014) 28:57–63. [link]

349. In vivo activation of a conserved microRNA program induces robust mammalian heart regeneration.
Aguirre, A., Montserrat, N., Zachiggna, S., Nivet, E., Hishida, T., Krause, M.N., Kurian, L., Ocampo, A., Vazquez-Ferrer, E., Rodriguez Esteban, C., Kumar, S., Moresco, J.J., Yates, J.R., Sancho-Martinez, I., Giacca, M. and Izpisua Belmonte, J.C.
Cell Stem Cell (2014) 15, 589–604. [link]

350. La reprogramacio regenerative abre las puertas a nuevas y revolucionarias terapias para el tratamiento de enfermedades cardiacas
Aguirre, A., Montserrat, N. and Izpisua Belmonte, J.C
Genetica Medica News (2014) 11:19-20.

351. A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells
Ding, Z., Sui, L., Ren, R., Liu, Y., Xu, X., Fu, L., Bai, R., Yuan, T., Hao, Y., Pan, H., Zhang, W., Liu, W., Yu, H., Yu, X., Yang, Z., Li, J., Wang, X., Izpisua Belmonte, J.C., Liu, G.-H., Yi, F. and Qu, J.
Protein & Cell (2014) ePub ahead of print. [link]

352. Stem cells: A designer's guide to pluripotency
Wu, J., and Izpisua Belmonte, J.C.
Nature (2014) 516, 172-173. [link]

2013

292. Analysis of protein coding mutations in hiPSCs and their possible functions during somatic cell reprogramming
Ruiz, S., Gore, A., Li, Z., Panopoulos, A.D., Montserrat, N., Fung, H.-L., Giorgetti, A., Bilic, J., Batchelder, E.M., Zaehres, H., Schöler, H.R., Zhang, K., and Izpisua Belmonte, J.C.
Nature Communications. (2012). 4:1382. [link]

293. Switching cell fate, ncRNAs coming to play
Guan, D., Zhang, W., Zhang, W., Liu, G.-H., and Izpisua Belmonte, J.C.
Cell Death and Disease. (2012). 4:e464. [link]

294. Prospects on hESC-derived pancreatic progenitor expansion
Sui, L., Liu, G.-H., and Izpisua Belmonte, J.C.
Cell Research. (2013). 23(5):592-4. [link]

295. Characterization of pluripotent stem cells
Marti, M., Mulero, L., Pardo, C., Morera, C., Carrió, M., Laricchia-Robbio, L., and Izpisua Belmonte, J.C.
Nature Protocols. (2012). 8(2):223-53. [link]

296. Surf the Waves of Reprogramming
Sancho-Martinez, I. and Izpisua Belmonte, J.C.
Nature. (2013). 493:310-311. [link]

297. Conversion of pericytes to neurons: a new guest at the reprogramming convention
Nivet, E., Sancho-Martinez, I., and Izpisua Belmonte, J.C.
Stem Cell Research & Therapy. (2013). 4(1):2. [link]

298. Dedifferentiation, Transdifferentiation, and Reprogramming: Future Directions in Regenerative Medicine
Eguizabal, C., Montserrat, N., Veiga, A., and Izpisua Belmonte, J.C.
Seminars in Reproductive Medicine. (2013). 31:82–94. [link]

299. Niche-less maintenance of HSCs by 2i
Masuda, S., Li, M., and Izpisua Belmonte, J.C.
Cell Research. (2013). (4):458-9. [link]

300. The microenvironment and resistance to personalized cancer therapy
Masuda, S. and Izpisua Belmonte, J.C.
Nature Reviews Clinical Oncology. (2013) 10(2):79. [link]

301. Autophagic control of cell "stemness"
Pan, H., Cai, N., Li, M., Liu, G.-H., and Izpisua Belmonte, J.C.
EMBO Molecular Medicine. (2013). 5, 327–331. [link]

302. Activin/ BMP2 chimeric ligands direct adipose-derived stem cells to chondrogenic differentiation
Peran, M., Ruiz, S., Kwiatkowski, W., Marchal, J.A., Yang, S-L., Aranega, A., Choe, S. , and Izpisua Belmonte, J.C.
Stem Cell Research. (2013). 10, 464-476. [link]

303. Reprogramming Towards Heart Regeneration: Stem Cells and Beyond
Aguirre, A., Sancho-Martinez, I., and Izpisua Belmonte, J.C.
Cell Stem Cell (2013). 12(3):275-84. [link]

304. Cotransplantation of MSCs and HSCs
Masuda, S. and Izpisua Belmonte, J.C.
Transplantation (2013). 95(10):e62-3. [link]

305. Polycomb complex recruitment in pluripotent stem cells
Barrero, M.J. and Izpisua Belmonte, J.C.
Nature Cell Biology (2013). 15(4):348-350. [link]

306. At the crossroads of targeted treatment and resistance in melanoma
Masuda, S. and Izpisua Belmonte, J.C.
The Lancet Oncology (2013). 14(4): e136-e137. [link]

307. Macrohistone Variants Preserve Cell Identity by Preventing the Gain of H3K4me2 during Reprogramming to Pluripotency
Barrero, M.J., Sese, B., Kuebler, B., Bilic, J., Boue, S., Marti, M., and Izpisua Belmonte, J.C.
Cell Reports (2013). 3(4):1005-11. [link]

308. Isolation and in vitro culture of primary cardiomyocytes from adult zebrafish hearts
Sander, V., Sune, G., Jopling, C., Morera, C., and Izpisua Belmonte, J.C.
Nature Protocols. (2013). 8(4):800-809. [link]

309. On the Search for Reliable Human Aging Models: Understanding Aging by Nuclear Reprogramming
Sancho-Martinez, I., Nivet, E. and Izpisua Belmonte, J.C.
Research and Perspectives in Neurosciences 20. (2013). [link].

310. Resetting Parkinson’s disease patient-derived cells to unveil new pathological marks
Nivet, E., Liu, G.-H., Montserrat, N., and Izpisua Belmonte, J.C.
Médecine/Sciences. (2013). (4):353-5. [link]

311. SMYD2 is induced during differentiation and participates in early development.
Sese, B., Barrero, M.J., Fabregat, M.C., Sander, V. and Izpisua Belmonte, J.C.
International Journal of Developmental Biology. (2013) 57:357-364. [link]

312. Macro histone variants are critical for the differentiation of human pluripotent cells.
Barrero, M.J., Sese, B., Marti, M. and Izpisua Belmonte, J.C.
Journal of Biological Chemistry. (2013) 288(22):16110-6. [link]

313. Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors
Zhang, K., Liu, G.-H., Yi, F., Montserrat, N., Hishida, T., Rodriguez Esteban, C. and Izpisua Belmonte, J.C.
Protein and Cell (2013). ePub Ahead of Print. [link]

314. "TET-on" pluripotency
Wang, P., Qu, J., Wu, M.Z., Zhang, W., Liu, G.-H. and Izpisua Belmonte, J.C.
Cell Research (2013). 23(7):863-5. [link]

315. Mitochondrial regulation in pluripotent stem cells
Xu, X., Duan, S., Yi, F., Ocampo, A., Liu, G.-H. and Izpisua Belmonte, J.C.
Cell Metabolism (2013). 18(3):325-32. [link]

316. Concealing cellular defects in pluripotent stem cells
Zhang, W., Qu, J., Suzuki, K., Liu, G.-H. and Izpisua Belmonte, J.C.
Trends in Cell Biology (2013). 23(12):587-592. [link]

317. Reprogramming of human fibroblasts to pluripotency with lineage specifiers.
Montserrat, N., Nivet, E., Sancho-Martinez, I., Hishida, T., Kumar, S., Miquel, L., Cortina, C., Hishida, Y., Xia, Y., Rodriguez Esteban, C. and Izpisua Belmonte, J.C.
Cell Stem Cell (2013). 13(3):341-50. [link]

318. Advances in cellular reprogramming: Moving toward a reprieve from immunogenicity
Gallegos, T., Sancho-Martinez, I. and Izpisua Belmonte, J.C.
Immunology Letters (2013). 155(1-2):14-7. [link]

319. Regulation of Somatic Stem Cell Function by DNA Methylation and Genomic Imprinting
Li, M., Kim, N.Y., Masuda, S. and Izpisua Belmonte, J.C.
Cell & Tissue Transplantation & Therapy (2013). 2013:5 19-23. [link]

320. A cut above the rest: targeted genome editing technologies in human pluripotent stem cells
Li, M., Suzuki, K., Kim, N.Y., Liu, G.-H. and Izpisua Belmonte, J.C.
Journal of Biological Chemistry (2013). ePub Ahead of Print. [link]

321. Will SCNT-ESCs Be Better than iPSCs for Personalized Regenerative Medicine?
Sancho-Martinez, I. and Izpisua Belmonte, J.C.
Cell Stem Cell (2013). (2):141-2 [link]

322. Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes.
Gu, Y., Liu, G.-H., Plongthongkum, N., Benner, C., Yi, F., Qu, J., Suzuki, K., Yang, J., Zhang, W., Li, M., Montserrat, N., Crespo, I., Del Sol, A., Esteban Rodriguez, C., Zhang, K. and Izpisua Belmonte, J.C.
Protein and Cell (2013). ePub Ahead of Print. [link]

323. MCAD Mediated Intercellular Interactions Activate Satellite Cell Division
Marti, M., Montserrat, N., Pardo, C., Mulero, L., Miquel-Serra, L., Miquel-Cavaco, A., Vaquero, J.A., Kuebler, B., Morera, C., Barrero, M.J. and Izpisua Belmonte, J.C.
Journal of Cell Science (2013). 126(Pt 22):5116-31. [link]

324. Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach
Masuda, S., Wu, J., Hishida, T., Pandian, G., Sugiyama, H. and Izpisua Belmonte, J.C.
Journal of Molecular Cell Biology (2013) 5(5):354-5. [link]

325. Oncofetal Gene SALL4 in Aggressive Hepatocellular Carcinoma
Masuda, S., Suzuki, K. and Izpisua Belmonte, J.C.
The New England Journal of Medicine (2013) 369;12: 1171. [link]

326. Heart Regeneration: A Tale of Cell Reprogramming
Aguirre, A., Sancho-Martinez, I., and Izpisua Belmonte, J.C.
Circulation Research (2013). 113:1109-1111. [link]

327. Gating pluripotency via nuclear pores
Yang, J., Cai, N., Yi, F., Liu, G.-H., Qu, J. and Izpisua Belmonte, J.C.
Trends in Molecular Medicine (2013) 20(1):1-7. [link]

328. Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells
Xia, Y., Nivet, E., Sancho-Martinez, I., Gallegos, T., Suzuki, K., Okamura, D., Wu, M.-Z., Dubova, I., Rodriguez Esteban, C., Montserrat, N., Campistol, J.M. and Izpisua Belmonte, J.C.
Nature Cell Biology (2013) 15(12):1507-15. [link]

329. MicroRNAs Contribute to iPSC-Somatic Donor Memory
Vitaloni, M., Pulecio, J., Bilic, J., Kuebler, B., Laricchia-Robbio, L. and Izpisua Belmonte, J.C.
Journal of Biological Chemistry (2013) ePub Ahead of Print. [link]

2012

248. Development and validation of an automated high-throughput system for zebrafish in vivo screenings.
Letamendia A., Quevedo C., Ibarbia I., Virto J.M., Holgado O., Diez M., Izpisua Belmonte J.C., Callol-Massot C.
PLoS One. (2012). ePub ahead of print. [link]

249. Generation of induced pluripotent stemcells from human renal proximal tubular cells with only two transcription factors: OCT4 and SOX2
Montserrat, N., Ramírez-Bajo, M.J., Xia, Y., Sancho-Martinez, I., Moya-Rull, , D., Miquel-Serra, L., Yang, S., Nivet, E., Cortina, C., González, F., Izpisua Belmonte, J.C., and Josep M. Campistol
The Journal of Biological Chemistry. (2012). ePub ahead of print. [link]

250. Gating neural development and aging via nuclear pores
Liu, G-H, Li, M., Qu, J., and Izpisua Belmonte, J.C.
Cell Research. (2012). 22:1212-1214. [link]

251. Gametogenesis in a dish
Gu, Y., Liu, G-H, and Izpisua Belmonte, J.C.
Cell Research. (2012). ePub ahead of print. [link]

252. Transient down regulation of Bmp signalling induces extra limbs in vertebrates
Christen, B., Cavaco Rodrigues, A.M., Barragán Monasterio, M., Fabregat Roig, C., and Izpisua Belmonte, J.C.
Development. (2012). 139.2557-2565. [link]

253. Induced neural stem cells: a new tool for studying neural development and neurological disorders
Liu, G-H, Yi, F., Suzuki, K., Qu, J., and Izpisua Belmonte, J.C.
Cell Research. (2012) 22(7):1087-91. [link]

254. Small molecule-mediated TGFβ Type II receptor degradation promotes cardiomyogenesis in embryonic stem cells
Willems, E., Cabral-Teixeira, J., Schade, D., Cai, W., Reeves, P., Bushway, P., Lanier, M., Walsh, C., Kirchhausen, T., Izpisua Belmonte, J.C., Cashman, J., and Mercola, M.
Cell Stem Cell. (2012) In Press. [link]

255. Accumulation of instability in serial differentiation and reprogramming of parthenogenetic human cells
Vassena, R., Montserrat, N., Carrasco Canal, B., Aran, B., de Oñate, L., Veiga, A., and Izpisua Belmonte, J.C.
Human Molecular Genetics. (2012). ePub ahead of print. [link]

256. Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and celltherapy
Yi, F., Liu, G-H, and Izpisua Belmonte, J.C.
Protein & Cell. (2012) (2012) 3(4): 246–250. [link]

257. Reprogramming based gene therapy for inherited red blood cell disorders
Xu, X., Qu, J., Suzuki, K., Li, M., Zhang, W., Liu, G-H, and Izpisua Belmonte, J.C.
Cell Research. (2012) 22:941-944. [link]

258. Induced pluripotent stem cells in clinical hematology: potentials, progress, and remaining obstacles
Panopoulos, A.D. and Izpisua Belmonte, J.C.
Current Opinion in Hematology. (2012) ) (2012) 19(4):256-60. [link]

259. Rejuvenating liver and pancreas through cell transdifferentiation
Yi, F., Liu, G-H, Izpisua Belmonte, J.C.
Cell Research. (2012) 22:616-619. [link]

260. Cellules Mare Embrionaries: Que en Sabem Despres de Trenta Anys D'Investigacio?
Montserrat, N., Aran, B., and Izpisua Belmonte, J.C.
Treballs de la SCB (2012) 63:215-233. [link]

261. iPS cells versus ES cells: Close enough or yet too far apart?
Bilic, J. and Izpisua Belmonte, J.C.
Stem Cells. (2012) 30:33–41. [link]

262. No factor left behind: generation of transgene free induced pluripotent stem cells.
Li, M. and Izpisua Belmonte, J.C.
American Journal of Stem Cells. (2012). 1(1):75-80. [link]

263. Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development.
Futterer, A., Raya, A., Liorente, M., Izpisua Belmonte, J.C., de la Pompa, J.L., Klatt, P., and Martinez-A, C.
Cell Death and Differentiation. (2012) 19:132-143. [link]

264. Skeletal muscle regeneration in Xenopus tadpoles and zebrafish larvae
Cavaco Rodrigues, A.M., Christen, B., Marti, M., Izpisua Belmonte, J.C.
BMC Developmental Biology. (2012) 12:9. [link]

265. p38α MAPK regulates myocardial regeneration in zebrafish
Jopling, C., Suñè, G., Morera, C., Izpisua Belmonte, J.C.
Cell Cycle. (2012) 11(6):1195-201. [link]

266. Cardiosphere-derived cells for heart regeneration
Masuda, S., Montserrat, N., Okamura, D., Suzuki K., and Izpisua Belmonte, J.C.
The Lancet. (2012). 379(9835): 2425-2426. [link]

267. Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc
Giorgetti, A., Marchetto, M., Li, M., Yu, D., Fazzina, R., Mu, Y., Adamo, A., Paramonov, I., Castaño Cardoso, J., Barragan Monasterio, M., Bardy, C., Cassiani-Ingoni, R. Liu, G-H, Gage F.H., and Izpisua Belmonte, J.C.
PNAS. (2012). ePub ahead of print. [link]

268. Establishment of hepatic and neural differentiation platforms of Wilson's disease specific induced pluripotent stem cells
Yi, F., Qu, J., Suzuki, K., Kim, NY, Liu, G-H, and Izpisua Belmonte, J.C.
Protein & Cell. (2012) ePub ahead of print. [link]

269. DNA Hypermethylation in Somatic Cells Correlates with Higher Reprogramming Efficiency
Barrero MJ, Berdasco M, Paramonov I, Bilic J, Vitaloni M, Esteller M, and Izpisua Belmonte, J.C.
Stem Cells. (2012) ePub ahead of print. [link]

270. Navigating the epigenetic landscape of pluripotent stem cells
Li, M., Liu, G-H, and Izpisua Belmonte, J.C.
Nature Reviews Molecular Cell Biology. (2012) 13, 524-535. [link]

271. Vitrified blastocysts from Preimplantation Genetic Diagnosis (PGD) as a source for human Embryonic Stem Cell (hESC) derivation
Aran, B, Sole, M., Rodriguez-Pizà, I., Parriego, M., Muñoz, Y., Boada, M., Barri, P.N., Izpisua Belmonte, J.C., and Veiga, A.
Journal of Assisted Reproduction and Genetics. (2012) ePub ahead of print. [link]

272. Post-translational modulation of pluripotency
Cai, N., Li, M., Qu, J., Liu, G-H, and Izpisua Belmonte, J.C.
Journal of Molecular Cell Biology. (2012) ePub ahead of print. [link]

273. Huntington’s disease: Dancing in a dish
Zhang, K., Yi, F., Liu, G-H, and Izpisua Belmonte, J.C.
Cell Research. (2012). ePub ahead of print. [link]

274. Lineage conversion methodologies meet the reprogramming toolbox
Sancho-Martinez, I., Baek, S.H., and Izpisua Belmonte, J.C.
Nature Cell Biology. (2012). In Press. [link]

275. The dawn of angiogenesis modeling: regenerating vasculature from human pluripotent stem cells
Yi, F., Qu, J., Liu, G.-H., and Izpisua Belmonte, J.C.
Cell Research. (2012). ePub ahead of print. [link]

276. Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells
Ruiz, S., Diep, D., Gore, A., Panopoulos, A.D., Montserrat, N., Plongthongkum, N., Kumar, S., Fung, H.-L., Giorgetti, A., Bilic, J., Batchelder, E.M., Zaehres, H., Kan, N.G.,
Schöler, H.R., Mercola, M., Zhang, K. and Izpisua Belmonte, J.C.
PNAS. (2012). ePub ahead of print. [link]

277. iPSC technology to study human aging and aging-related disorders
Liu, G.-H., Ding, Z., and Izpisua Belmonte, J.C.
Current Opinion in Cell Biology. (2012). ePub ahead of print. [link]

278. Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial
Masuda, S. and Izpisua Belmonte, J.C.
The Lancet Oncology. (2012).13(10): e409. [link]

279. In vitro generation of platelets through direct conversion: first report in My Knowledge (iMK)
Masuda, S., Li, M., and Izpisua Belmonte, J.C.
Cell Research. (2012). ePub ahead of Print. [link]

280. Generation of a drug-inducible reporter system to study cell reprogramming in human cells
Ruiz, S., Panopoulos, A.D., Montserrat, N., Multon, M.-C., Daury, A., Rocher, C.,Spanakis, E., Batchelder, E.M., Orsini, C., Deleuze, J.-F., and Izpisua Belmonte, J.C.
Journal of Biological Chemistry. (2012). ePub ahead of Print. [link]

281. Medicina regenerativa: la revolución de nuestro siglo.
Barrero, M.J. and Izpisua Belmonte, J.C.
Investigacion y Ciencia. (2012). November, 2012. [link]

282. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
Liu, G.-H., Qu, J., Suzuki, K., Li, M., Montserrat, N., Yi, F., Xu, X., Ruiz, S., Zhang, W., Ren, B., Wagner, U., Kim, A., Li, Y., Goebl, A., Kim, J., Soligalla, R.D., Dubova, I., Thompson, J., Yates, J., Rodriguez Esteban, C., Sancho-Martinez, I. and Izpisua Belmonte, J.C.
Nature. (2012). ePub ahead of print. [link]

283. Neuronopathic Gaucher's Disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds
Tiscornia, G., Lorenzo Vivas, E., Matalonga, L., Berniakovich, I., Barragán Monasterio, M., Eguizábal Argaiz, C., Gort, L., González, F., Ortiz Mellet, C., García Fernández, J.M., Ribes, A., Veiga, A., and Izpisua Belmonte, J.C.
Human Molecular Genetics. (2012). ePub ahead of print. [link]

284. Beating in a dish: new hopes for cardiomyocyte regeneration
Gu, Y., Yi, F., Liu, G.-H., and Izpisua Belmonte, J.C.
Cell Research. (2012). ePub ahead of print. [link]

285. N-acetylcysteine protects induced pluripotent stem cells from in vitro stress: impact on differentiation outcome
Berniakovich, I., Laricchia-Robbio, L., and Izpisua Belmonte, J.C.
The International Journal of Developmental Biology. (2012). ePub ahead of print. [link]

286. Compound screening platform using human induced pluripotent stem cells to identify small molecules that promote chondrogenesis
Yang, S.-L., Harnish, E., Leeuw, T., Dietz, U., Batchelder, E., Wright, P.S., Peppard, J., August, P., Volle-Challier, C., Bono, F., Herbert, J.-M. and Izpisua Belmonte, J.C.
Protein and Cell. (2012). ePub ahead of print. [link]

287. Hypoxia induces myocardial regeneration in zebrafish
Jopling, C., Suñe, G., Faucherre, A., Fabregat, C. and Izpisua Belmonte, J.C.
Circulation. (2012). 126:3017-3027. [link]

288. Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells
Okamura, D., Maeda, I., Taniguchi, H., Tokitake, Y., Ikeda, M., Ozato, K., Mise, N., Abe, K., Noce, T., Izpisua Belmonte, J.C., and Matsui, Y.
Genes and Development. (2012). ePub ahead of print. [link]

289. Conversion of human fibroblasts to angioblast-like progenitor cells
Kurian, L., Sancho-Martinez, I., Nivet, E., Aguirre, A., Moon, K., Pendaries, C., Volle-Challier, C., Bono, F., Herbert, J.-M., Pulecio, J., Xia, Y., Li, M., Montserrat, N., Ruiz, S., Dubova, I., Rodriguez, C., Denli, A.M., Boscolo, F.S., Thiagarajan, R.D., Gage, F., Loring, J.F., Laurent, L.C., and Izpisua Belmonte, J.C.
Nature Methods. (2012). ePub ahead of print. [link]

290. Reprogramming development and aging: cell differentiation as a malleable process
Izpisua Belmonte, J.C.
Current Opinion in Cell Biology. (2012). ePub ahead of print. [link]

291. New march towards the regeneration of sensation and cognition: hear more, see more and learn more
Zhang, K., Yi, F., Liu, G.-H., and Izpisua Belmonte, J.C.
Journal of Molecular Cell Biology. (2012). 5(2):151-3. [link]

2011

207. Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ES and iPS Cells during Reprogramming and Time in Culture.
Laurent, L.C., Ulitsky, I., Slavin, I., Tran, H., Schork, A., Morey, R., Lynch, C., Harness, J., Lee, S., Barrero, M.J., Martynova, M., Muller, F.-J., Semechkin, R., Galat, V., Gottesfeld, J., Izpisua Belmonte, J.C., Murray, C., Keirstead, H., Park, H.-S., Schmidt, U., Laslett, A., Nievergelt, C., Shamir, R. and Loring, J.
Cell Stem Cell. (2011) 8:106-118. [link]

208. Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration.
Jopling, C., Boue, S. and Izpisua Belmonte, J.C.
Nature Reviews Molecular Cell Biology. (2011) 12:79-89. [link]

209. Cell fate conversion by mRNA.
Li, M., Sancho-Martinez, I. and Izpisua Belmonte, J.C.
Stem Cell Research and Therapy. (2011) 2:5. [link]

210. Cre-LoxP-regulated expression of monoclonal antibodies driven by an ovalbumin promoter in primary oviduct cells.
Oishi, I., Kim, S., Yoshii, K., Rodriguez Esteban, C. and Izpisua Belmonte, J.C.
BMC Biotechnology. (2011) 11:5. [link]

211. A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity.
Ruiz, S., Panopoulos, A.D., Herrerias, A., Bissig, K-D, Lutz, M., Berggren, W.T., Verma, I. and Izpisua Belmonte, J.C.
Current Biology. (2011) 21: 45-52. [link]

212. Somatic coding mutations in human induced pluripotent stem cells.
Gore, A., Li, Z., Fung, H.L., Young, J., Agarwal, S., Antosiewicz-Bourget, J., Canto, I., Giorgetti, A., Israel, M., Kiskinis, E., Lee, J.H., Loh, Y.H., Manos, P.D., Montserrat, N., Panopoulos, A.D., Ruiz, S., Wilbert, M., Yu, J., Kirkness, E.F., Izpisua Belmonte, J.C., Rossi, D.J., Thomson, J., Eggan, K., Daley, G.Q., Goldstein, L.S.B. and Zhang, K.
Nature. (2011) 471:46-7. [link]

213. Regenerating the Epigenome.
Barrero, M.J. and Izpisua Belmonte, J.C.
EMBO Reports. (2011) 12:208-215. [link]

214. Modelling Long QT Syndrome with iPS cells: Be still, my beating heart...
Tiscornia, G., Montserrat, N. and Izpisua Belmonte, J.C.
Circulation Research. (2011) 108:648-649. [link]

215. Simple generation of human induced Pluripotent stem cells using Poly({beta}-Amino Esters) as non-viral gene delivery system.
Montserrat, N., Garreta Bahima, E., Gonzalez, F., Gutierrez, J., Eguizabal, C., Ramos Perez, V., Borros, S., Izpisua Belmonte, J.C.
Journal of Biological Chemistry. (2011) 286:12417-28. [link]

216. Methods for making iPS cells: reprogramming à la carte.
Gonzalez, F., Boue, S. and Izpisua Belmonte, J.C.
Nature Reviews Genetics. (2011) 12:231-242. [link]

217. iPSCs: Induced Back to Controversy.
Panopoulos, A., Ruiz, S. and Izpisua Belmonte, J.C.
Cell Stem Cell. (2011) 8:347-348. [link]

218. iPS cells forgive but do not forget.
Barrero, M.J. and Izpisua Belmonte, J.C.
Nature Cell Biology. (2011) 13:523–525. [link]

219. Recapitulation of premature ageing with iPSCs from Huchinson-Gilford progeria syndrome.
Liu, G-H, Barkho, B.Z., Ruiz, S., Diep, D., Qu, J., Yang, S-L, Panopoulos, A.D., Suzuki, K., Kurian, L., Walsh, C., Thompson, J., Boue, S., Fung, H.L., Sancho-Martinez, I., Zhang, K., Yates III, J. and Izpisua Belmonte, J.C.
Nature. (2011) 472:221-5. [link]

220. Rapid and highly efficient generation of induced pluripotent stem cells from human umbilical vein endothelial cells.
Panopoulos, A., Ruiz, S., Yi, F., Herrerias, A., Batchelder, E.M. and Izpisua Belmonte, J.C.
PLoS ONE. (2011) 6:e19743. [link]

221. Human cord blood reprogrammed into embryonic-like stem cells.
Giorgetti, A., Fazzina, R., Li, M. and Izpisua Belmonte, J.C.
ISBT Science Series. (2011) 6:107-111. [link]

222. The cell cycle inhibitor p27Kip1 controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist.
Menchon, C., Edel, M. and Izpisua Belmonte, J.C.
Cell Cycle. (2011) 10:1435-1447. [link]

223. A protocol to assess cell cycle and apoptosis in human and mouse pluripotent cells.
Edel, M., Menchon, C., Andres Vacquero, J.M. and Izpisua Belmonte, J.C.
Cell Communication and Signaling. (2011) 9:8 [link]

224. Disease correction, the iPSC way. Advances in iPSC-based therapy.
Sancho-Martinez, I., Li, M. and Izpisua Belmonte, J.C.
Clinical Pharmacology and Therapeutics. (2011) 89:746-749. [link]

225. Targeted Gene Correction of Laminopathy-Associated LMNA Mutations in Patient-Specific iPSCs.
Liu, G-H, Suzuki, K., Qu, J., Sancho-Martinez, I., Yi, F., Li, M., Kumar, S., Nivet, E., Kim, J., Soligalla, R.D., Dubova, I., Goebl, A., Plongthongkum, N., Fung, H.L., Zhang, K., Loring, J.F., Laurent, L.C., Izpisua Belmonte, J.C.
Cell Stem Cell. (2011) 8:688-694. [link]

226. LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells.
Adamo, A., Sese, B., Boue, S., Castano, J., Paramonov, I., Barrero, M.J. and Izpisua Belmonte, J.C.
Nature Cell Biology. (2011) 13:652-660. [link]

227. Complete meiosis from human induced pluripotent stem cells.
Eguizabal, C., Montserrat, N., Vassena, R., Barragan, M., Garreta, E., Garcia-Quevedo, L., Vidal, F., Giorgetti, A., Veiga, A. and Izpisua Belmonte, J.C.
Stem Cells. (2011) 29:1186-1195. [link]

228. Pluripotency of Male Germline Stem Cells.
Kim, S. and Izpisua Belmonte, J.C.
Molecules and Cells. (2011) March 24 Epub Ahead of Print. [link]

229. Efficient Generation of Hematopoietic Precursors and Progenitors from Human Pluripotent Stem Cell Lines.
Woods, N-B, Parker, A.S., Moraghebi, R., Lutz, M.K., Firth, A.L., Brennand, K.J., Berggren, W.T., Raya, A., Izpisua Belmonte, J.C., Gage, F.H. and Verma, I.M.
Stem Cells. (2011) 29:1158–1164. [link]

230. Study of pluripotency markers in zebrafish embryos and transient ES cell cultures.
Robles, V., Marti, M. and Izpisua Belmonte, J.C.
Zebrafish. (2011) 8:57-63. [link]

231. Waves of early transcriptional activation and pluripotency program initiation during human preimplantation development.
Vassena, R., Boue, S., Gonzalez Roca, E., Aran, B., Auer, H., Veiga, A., and Izpisua Belmonte, J.C.
Development. (2011) 138:3699-3709. [link]

232. Anaerobicizing into Pluripotency.
Panopoulos, A.D. and Izpisua Belmonte, J.C.
Cell Metabolism. (2011) 14:143-4. [link]

233. A Src-Tks5 Pathway Is Required for Neural Crest Cell Migration during Embryonic Development.
Murphy, D.A., Diaz, B., Bromann, P.A., Tsai, J.H., Kawakami, Y., Maurer, J., Stewart, R.A., Izpisua Belmonte, J.C., and Courtneidge, S.A.
PLoS ONE. (2011) 6:e22499. [link]

234. Islet1-mediated activation of the ß-catenin pathway is necessary for hindlimb initiation in mice.
Kawakami, Y., Marti, M., Kawakami, H., Itoh, J., Quach, T., Johnson, A., Sahara, S., O'Leary, D.D.M., Nakagawa, Y., Lewandoski, M., Pfaff, S., Evans, S., and Izpisua Belmonte, J.C.
Development. (2011) 138:4465-4473. [link]

235. Diseases in a Dish: modeling human genetic disorders using induced pluripotent cells.
Tiscornia, G. and Izpisua Belmonte, J.C.
Nature Medicine. (2011) 12:1570-6. [link]

236. LSD1 and Pluripotency: A new player in the network.
Adamo, A., Barrero, M.J. and Izpisua Belmonte, J.C.
Cell Cycle. (2011) 10:3215-3216. [link]

237. Efficient Generation of A9 Midbrain Dopaminergic Neurons by Lentiviral Delivery of LMX1A in Human Embryonic Stem Cells and iPS Cells.
Sanchez-Danes A., Consiglio A., Richaud Y., Rodríguez-Pizà I., Dehay B., Edel M., Bové J., Memo M., Vila M., Raya A., and Izpisua Belmonte J.C.
Human Gene Therapy. (2011) 22:1 [link]

238. The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming.
Panopoulos, A.D., Yanes, O., Ruiz, S., Kida, Y.S., Diep, D., Tautenhahn, R., Herrerias, A., Batchelder, E.M., Plongthongkum, N., Lutz, M., Berggren, W.T., Zhang, K., Evans, R.M., Suizdak, G., and Izpisua Belmonte, J.C.
Cell Research. (2011) 22(1):168-77. [link]

239. Histone H1 variants are differentially expressed and incorporated into chromatin during differentiation and reprogramming to pluripotency.
Terme, J.-M., Sese, B., Millan-Ariño, L., Mayor, R., Izpisua Belmonte, J.C., Barrero, M.J., and Jordan, A.
Journal of Biological Chemistry. (2011) 286:35347–35357. [link]

240. Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs
Li, M., Suzuki, K., Qu, J., Saini, P., Dubova, I., Yi, F., Lee, J., Sancho-Martinez, I., Liu, G-H, and Izpisua Belmonte, J.C.
Cell Research. (2011) ePub ahead of print November 22, 2011. [link]

241. Identification of Phosphorylase Kinase as a Novel Therapeutic Target through High-throughput Screening for Anti-angiogenesis Compounds in Zebrafish
Camus, S., Quevedo, C., Menendez, S., Paramonov, I., Stouten, P., Janssen, R., Rueb, S., He, S., Snaar-Jagalska, E., Laricchia-Robbio, L., and Izpisua Belmonte, J.C.
Oncogene (2011) ePub ahead of print December 19, 2011. [link]

242. Cut and Paste: restoring cellular function by gene correction
Liu, G-H, Sancho-Martinez, I., and Izpisua Belmonte, J.C.
Cell Research. (2011) ePub ahead of print December 6, 2011. [link]

243. The labyrinth of nuclear reprogramming
Sancho-Martinez, I., Nivet, E., and Izpisua Belmonte, J.C.
Journal of Molecular Cell Biology. (2011) ePub ahead of print November 16, 2011. [link]

244. Increased dosage of tumor suppressors limits the tumorigenicity of iPS cells without affecting their pluripotency
Menendez, S., Camus, S., Herreria, A., Paramonov, I., Batlle Morera, L., Collado, M., Pekarik, V., Maceda, I., Edel, M., Consiglio, A., Sanchez, A., Li, H., Serrano, M. and Izpisua Belmonte, J.C.
Aging Cell. (2011). ePub ahead of print November 10, 2011. [link]

245. Chapter 9: Induced pluripotent stem cells from cord blood CD133+ cells using Oct4 and Sox2.
Giorgetti, A., Montserrat, N. and Izpisua Belmonte, J.C.
Lineage-Specific Differentiation of Human Embryonic and Induced Pluripotent Stem Cells Methods and Protocol. (2011) Springer Protocol Handbook Series.

246. Chapter 15: Retroviral-vector based approaches for the generation of human induced pluripotent stem cells from fibroblasts and keratinocytes.
Panopoulos, A., Ruiz, S. and Izpisua Belmonte, J.C.
Lineage-Specific Differentiation of Human Embryonic and Induced Pluripotent Stem Cells Methods and Protocol. (2011) Springer Protocol Handbook Series.

247. Plucked hair: how to get stem cells and induced pluripotent stem cells for future clinical applications.
Montserrat, N. and Izpisua Belmonte, J.C.
Handbook of Hair in Health and Disease. (2011) Wageningen Academic Publishers.

2010

181. Embryonic Stem Cell-like Cells Derived from Adult Human Testis.
Mizrak, S.C., Chikhovskaya, J.V., Sadri-Ardekani, H., van Daalen, S., Korver, C.M., Hovingh, S.E., Roepers-Gajadien, H.L., Raya, A., Fluiter, K., de Reijke, Th.M., de la Rosette, J.J.M.C.H., Izpisua Belmonte, J.C., van der Veen, F., de Rooij, D.G. and van Pelt, A.M.M.
Human Reproduction. (2010) 25:158-167. [link]

182. BMP and Activin membrane-bound inhibitor (BAMBI) reveal the involvement of the TGF-b family in pain modulation.
Tramullas, M., Diaz, A., San-Emeterio, E.P., Morchon, N., Lantero, A., Merino, D., Buscher, D., Merino, R., Hurle, J.M., Izpisua Belmonte, J.C. and Hurle, M.
Journal of Neuroscience. (2010) 30:1502–1511. [link]

183. Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells.
Sugii, S., Kida, Y., Kawamura, T., Suzuki, J., Vassena, R., Yin, Y.Q., Lutz, M., Berggren, W.T., Izpisua Belmonte, J.C. and Evans, R.M.
PNAS. (2010) 107:3558-3563. [link]

184. Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells.
Aasen, T. and Izpisua Belmonte, J.C.
Nature Protocols. (2010) 5:371-382. [link]

185. A protocol describing the genetic correction of somatic human cells and subsequent generation of iPS cells.
Raya, A., Rodriguez-Piza, I., Navarro, S., Richaud, Y., Guenechea, G., Sanchez-Danes, A., Consiglio, A., Bueren, J. and Izpisua Belmonte, J.C.
Nature Protocols. (2010) 5:647-660. [link]

186. Regeneration and reprogramming compared.
Christen, B., Robles, V., Paramonov, I., Raya, M. and Izpisua Belmonte, J.C.
BMC Biology. (2010) 8:5. [link]

187. Transcriptomics approach to investigate zebrafish heart regeneration.
Sleep, E., Boue, S., Jopling, C., Raya, M., Raya, A. and Izpisua Belmonte, J.C.
Journal of Cardiovascular Medicine. (2010) 11:369-80. [link]

188. Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1.
Edel, M., Menchon, C., Menendez, S., Consiglio, A., Raya, A. and Izpisua Belmonte, J.C.
Genes and Development. (2010) 24:561–573. [link]

189. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation.
Jopling, C., Raya, M., Sleep, E., Marti, M., Raya, A. and Izpisua Belmonte, J.C.
Nature. (2010) 464:606-609. [link]

190. Generation of induced pluripotent stem cells from human cord blood cells with only 2 factors: Oct4 and Sox 2.
Giorgetti, A., Montserrat, N., Rodriguez-Piza, I, Azqueta, C., Veiga, A., and Izpisua Belmonte, J.C.
Nature Protocols. (2010) 5:811-820. [link]

191. BMP-2/6 Heterodimer Is More Effective than BMP-2 or BMP-6 Homodimers as Inductor of Differentiation of Human Embryonic Stem Cells.
Valera, E., Issacs, M., Kawakami. Y., Izpisua Belmonte, J.C. and Choe, S.
PLoS ONE. (2010) 5:e11167. [link]

192. Understanding the molecular basis for cardiomyocyte cell cycle regulation: new insights in cardiac regeneration after injury?
Montserrat, N., Jopling, C. and Izpisua Belmonte, J.C.
Expert Review of Cardiovascular Therapy. (2010) 8:1043-1045. [link]

193. Derivation of human embryonic stem cells at the Center for Regenerative Medicine in Barcelona
Aran B, Rodriguez-Pizà I, Raya A, Consiglio A, Muñoz Y, Barri PN, Izpisua JC, Veiga A
In Vitro Cellular & Developmental Biology - Animal. (2010) 46:356-366. [link]

194. Reprogramming with defined factors: from induced pluripotency to induced transdifferentiation.
Masip, M., Veiga, A., Izpisua Belmonte, J.C. and Simon, C.
Molecular Human Reproduction. (2010) 16:856-868. [link]

195. Identification of a novel progenitor cell population from adult human cardiac adipose tissue with potential for cardiac repair.
Bayes-Genis, A., Soler-Botija, C., Farre, J., Sepulveda, P., Raya, A., Roura, S., Prat-Vidal, C., Galvez, C., Anastasio Montero, J., Buscher, D. and Izpisua Belmonte, J.C.
Journal of Molecular and Cellular Cardiology. (2010) 49:771-780. [link]

196. Turning human epidermis into pancreatic endoderm.
Santamaria, P., Rodriguez-Piza, I., Clemente-Casares, X., Yamanouchi, J., Aasen, T., Raya, A. and Izpisua Belmonte, J.C.
The Review of Diabetic Studies. (2010) 7:151-160. [link]

197. BMP-2 and BMP-6 heterodimer illustrates the nature of ligand-receptor assembly.
Issacs, M.J., Kawakami, Y., Allendorph, G., Yoon, J., Izpisua Belmonte, J.C. and Choe, S.
Molecular Endocrinology. (2010) 24:1469-1477. [link]

198. The cell cycle and pluripotency: Is there a direct link?
Edel, M. and Izpisua Belmonte, J.C.
Cell Cycle. (2010) 9:2694-2695. [link]

199. Analysis of Human and Mouse Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells. What is in the Plate?
Boue, S., Paramonov, I., Barrero, M.J. and Izpisua Belmonte, J.C.
PLoS ONE. (2010) 5:e12664. [link]

200. Rem2 GTPase controls proliferation and apoptosis of neurons during embryo development
Edel, M. and Izpisua Belmonte, J.C.
Cell Cycle. (2010) 9:3414-3422. [link]

201. p53:Guardian of reprogramming.
Menendez, S., Camus, S. and Izpisua Belmonte, J.C.
Cell Cycle. (2010) 9:3887-3891. [link]

202. Epigenetic Mechanisms that Regulate Cell Identity.
Barrero, M.J., Boue, S. and Izpisua Belmonte, J.C.
Cell Stem Cell. (2010) 5:565-570. [link]

203. Stem Cell Research in Spain: if only they were windmills...
Veiga, A., Raya, A. and Izpsiua, J.C.
2010 World Stem Cell Summit. (2010) [link]

204. MicroRNAs in stem cell function and fate.
Tiscornia, G. and Izpisua Belmonte, J.C.
Genes and Development. (2010) 24: 2732-2741. [link]

205. High-efficient generation of induced pluripotent stem cells from human astrocytes.
Ruiz, S., Brennand, K., Panopoulos, A.D., Herrerias, A. Gage, F.H. and Izpisua Belmonte, J.C.
PLoS ONE. (2010) 5:e15526. [link]

206. Generation of Pig iPS Cells: A Model for Cell Therapy.
Montserrat N, Bahima EG, Batlle L, Häfner S, Rodrigues AM, Gonzalez F, Izpisua Belmonte JC.
J Cardiovasc Transl Res. (2010) 4:121-130. [link]

2009

161. Sall genes regulate region specific morphogenesis in the limb by modulating Hox activities.
Kawakami, Y., Uchiyama, Y., Rodriguez Esteban, C., Toshiaki, I., Kawakami, H., Marti, M., Kmita, M., Monaghan-Nicols, P., Nishinakamura, R. and Izpisua Belmonte, J.C.
Development. (2009) 136:585-594. [link]

162. Derivació de línies de cèl·lules mare embrionàries humanes.
B. Aran, I.Rodriguez, A.Raya, Y.Muñoz, P.N.Barri, J.C.Izpisua, A.Veiga.
Biologia de la Reproducció. Treballs de la SCB (2009) 59:263-275. [link]

163. Cursos de Formación Continuada 2009
A.Veiga, B.Aran, J.C. Izpisua.
Consejo General de Colegios Oficiales de Farmaceuticos. (2009) [link]

164. Generation of cardiomyocytes from new human embryonic stem cell lines derived from poor-quality blastocysts.
Raya, A., Rodriguez-Piza, I., Aran, B., Consiglio, A., Barri, P., Veiga, A., and Izpisua Belmonte, J.C.
73rd Cold Spring Harbor Laboratory Symposium. (2009) 73:1-9. [link]

165. ErbB2 and ErbB3 regulate amputation-induced proliferation and migation during vertebrate regeneration.
Rojas-Muñoz, A., Rajadhyksha, S., Gilmour, D., van Bebber, F., Rodríguez-Esteban, C., Nüsslein-Volhard, C., & Izpisua Belmonte, J.C.
Developmental Biology. (2009) 327: 177-190. [link]

166. A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts.
Fink, M., Chu, A., Ruiz-Lozano, P., Callol, C., Izpisua Belmonte, J.C., Giles, W., Bodmer, R. and Ocorr, K.
Biotechniques. (2009) 46: 101-113. [link]

167. Cilia-Where Two Wnts Collide.
Jopling, C. and Izpisua Belmonte, J.C.
Zebrafish. (2009) 6: 15-19. [link]

168. Beyond early development: Xenopus as an emerging model for the study of regenerative mechanisms.
Beck, C., Izpisua Belmonte, J.C. and Christen, B.
Developmental Dynamics. (2009) 238:1226-1248 [link]

169. Generation of mouse induced pluripotent stem cells by transient expression of a single non-viral polycistronic vector.
Gonzalez, F., Barragan Monasterio, M., Tiscornia, G., Montserrat Pulido, N., Vassena, R., Batlle Morera, L., Rodriguez Piza, I. and Izpsiua Belmonte, J.C.
PNAS. (2009) 106:8918-8922. [link]

170. Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPk/PI3K and Smad2/3 pathways.
Kelber, J.A., Panopoulos, A.D., Shani, G., Booker, E.C., Belmonte, J.C., Vale, W.W. and Gray, P.C.
Oncogene. (2009) 28: 2324-2336. [link]

171. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells.
Raya, A., Rodriguez-Piza, I., Guenechea, G., Vassena, R., Navarro, S., Barrero, M.J., Consiglio, A., Rio, P., Sleep, E., Tiscornia, G., Garreta, E., Aasen, T., Veiga, A., Verma, I., Bueren, J. and Izpisua Belmonte, J.C.
Nature. (2009) 460:53-61. [link]

172. Stem Cell Research in Spain: If Only They Were Windmills.
Raya, A. and Izpisua Belmonte, J.C.
Cell Stem Cell. (2009) 4:483-486 [link]

173. Linking the p53 tumour suppressor pathway to somatic cell reprogramming.
Kawamura, T., Suzuki, J., Wang, Y.V., Menendez, S., Batlle, L., Wahl, G. and Izpisua Belmonte, J.C.
Nature. (2009) 460:1140-1144. NIHMSID # 134470. [link]

174. Compensatory growth mechanisms regulated by BMP and FGF signaling pathways mediate liver regeneration in zebrafish after partial hepatectomy.
Kan, N., Junghans, D. and Izpisua Belmonte, J.C.
FASEB. (2009) 23:3516-3525. [link]

175. Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2.
Giorgetti, A., Montserrat, N., Aasen, T., Rodriguez-Piza, I., Vassena, R., Gonzalez, F., Boue, S., Barrero, M.J., Aran Corbella, B., Raya, A., Torrebadella, M., Veiga, A. and Izpisua Belmonte, J.C.
Cell Stem Cell. (2009) 5:353-357. NIHMSID # 147979. [link]

176. Induced pluripotent stem cells and reprogramming: seeing the science through the hype.
Izpisua Belmonte, J.C., Ellis, J., Hochedlinger, K. and Yamanaka, S.
Nature Reviews Genetics. (2009) 10:878-883. [link]

177. Reprogramming of human fibroblasts to induced pluripotent stem cells under xeno-free conditions.
Rodriguez-Piza, I., Richaud-Patin, Y., Vassena, R., Gonzalez, F., Barrero, M.J., Veiga, A., Raya, A. and Izpisua Belmonte, J.C.
Stem Cells. (2009) 28:36–44. [link]

178. A histone demethylase is necessary for regeneration in zebrafish.
Stewart, S., Tsun, Z.Y. and Izpisua Belmonte, J.C.
PNAS. (2009) 106:19889-19894. [link]

179. Left-right asymmetry determination.
Ibanes, M. and Izpisua Belmonte, J.C.
Wiley Interdisciplinary Reviews: Systems Biology and Medicine. (2009) Sept/Oct 2009:210-219. [link]

180. CiliaKeratinocyte induced pluripotent stem cells: from hair to where?
Aasen, T. and Izpisua Belmonte, J.C.
Stem Cells and Regenerative Medicine. (2009) Springer Science (Humana).

2008

146. Albumin-associated Lipids Regulate Human Embryonic Stem Cell Self-Renewal.
Garcia-Gonzalo, F.R. and Izpisua Belmonte, J.C.
PLoS ONE. (2008) 3:e1384. [link]

147. Tbx3 controls hepatic stem cell fate in liver development by suppressing p19ARF expression.
Suzuki, A., Sayaka, S., Buscher, D., Izpisua Belmonte, J.C., and Taniguchi, H.
Development. (2008) 135:1589-1595 [link]

148. Retinoic Acid Regulation of the Mesp-Ripply Feedback Loop During Vertebrate Segmental Patterning.
Moreno, T.A., Jappelli, R., Brenner, S., Izpisua Belmonte, J.C., and Kintner, C.
Developmental Biology. (2008) 315:317-330. [link]

149. Directional gut looping is mediated by changes in the extracellular matrix and in cell:cell adhesion.
Kurpios, N.A., Ibanes, M., Davis, N.M., Lui, W., Katz, T., Martin, J.F., Izpisua Belmonte, J.C. and Tabin, C.J.
PNAS. (2008) 105:8499-8506. [link]

150. Pitx2 regulates gonad morphogenesis.
Rodriguez-Leon, J., Rodriguez Esteban, C., Marti, M., Santiago-Josefat, B., Dubova, I., Rubiralta, X., and Izpisua Belmonte, J.C.
PNAS. (2008) 105:11242-11247. [link]

151. NFIX-One Gene, Two Knockouts, Multiple Effects.
Pekarik, V. and Izpisua Belmonte, J.C.
Journal of Biology. (2008) 7:29. [link]

152. Theoretical and experimental approaches to understand morphogen gradients.
Ibanes, M and Izpisua Belmonte, J.C.
Nature Molecular Systems Biology. (2008) 4:176. [link]

153. Insights into the establishment of left-right asymmetries in vertebrates.
Raya, A. and Izpisua Belmonte, J.C.
BDRC: Embryo Today. (2008) 84(2):81-94. [link]

154. Highly efficient generation of induced pluripotent stem cells from human keratinocytes.
Aasen, T., Raya, A., Barrero, M.J., Garreta, E., Consiglio, A., Gonzalez, F., Vassena, R., Bilic, J., Pekarik, V., Tiscornia, G., Edel, M., Boue, S. and Izpisua Belmonte, J.C.
Nature Biotechnology. (2008) 26:1276-1284. [link]

155. The Forkhead protein, FoxJ1, specified node-like cilia in Xenopus and Zebrafish embryos.
Stubbs, J., Oishi, I., Izpisua Belmonte, J.C. and Kintner, C.
Nature Genetics. (2008) 40:1454-1460. [link]

156. Molecular cloning and developmental expression of a hyaluronan and proteoglycan link protein gene, crtl1/hapln1, in zebrafish.
Kang, J.S., Kawakami, Y., Bekku, Y., Ninomiya, Y., Izpisua Belmonte, J.C., and Oohashi, T.
Zoological Science. (2008) 25:912-918. [link]

157. Subtractive hybridization and construction of cDNA libraries.
Blumberg, B. and Izpisua Belmonte, J.C.
Molecular Embryology: Methods and Protocols, Second Edition (2008) (Sharpe, P.T. and I. Mason, Ed.), Humana Press, N.J. [link]

158. Differential display of eukaryotic mRNA.
Tugores-Cester, A. and Izpisua Belmonte, J. C.
Molecular Embryology: Methods and Protocols, Second Edition (2008) (Sharpe, P.T. and I., Mason, Ed.), Humana Press, N.J. [link]

159. Maintenance of embryonic stem cell pluripotency by Nanog-mediated dedifferentiation of committed mesoderm progenitors.
Suzuki, A., Raya, A., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F.H., Rodriguez-Esteban, C., Izpisua Belmonte, J.C.
Regulatory Networks in Stem Cells. (2008) (Rajasekhar, V.K. and Vemuri, M.C.), Humana Press, N.J. [link]

160. Epigenetic Mechanisms Controlling Mesodermal Specification.
Barrero, M.J. and Izpisua Belmonte, J.C.
StemBook (2008) (Girard, L. and Chien, K.), Harvard Stem Cell Institute, MA. [link]

2007

137. Miles apart-mediated regulation of cell-Fibronectin interaction is required for proper myocardial migration in zebrafish.
Matsui, T., Raya, A., Callol, C., Kawakami, Y., Oishi, I., Rodriguez-Esteban, C., and Izpisua Belmonte, J.C.
Nature Clinical Practice Cardiovascular Medicine. (2007) 4:S77-S82. [link]

138. Lysosomal cathepsins in embryonic programmed cell death.
Zuzarte-Luis, V., Montero, J.A., Kawakami, Y., Izpisua Belmonte, J.C., and Hurle, J.
Developmental Biology. (2007) 301:205-217. [link]

139. El pez cebra:la navaja suiza de la biologia.
Rojas-Munoz, A., Bernad Miana, A., and Izpisua Belmonte, J.C.
Investigacion y Ciencia. (2007) 366:62-69. [link]

140. Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart regionalization and looping.
Ribeiro, R., Kawakami, Y., Buscher, D., Raya, A., Rodriguez-Leon, J., Morita, M., Rodriguez Esteban, C., Izpisua Belmonte, J.C.
PLoS One. (2007) 4:e398. [link]

141. Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning
Sahara, S., Kawakami, Y., Izpisua Belmonte, J.C., O’Leary, D.D.M.
Neural Development. (2007) 2:10. [link]

142. Bioelectricity and epimorphic regeneration.
Stewart, S., Rojas-Munoz, A., and Izpisua Belmonte, J.C.
Bioessays. (2007) 29(11):1133-1137. [link]

143. BMP-3 and BMP-6 Structures Illuminate the Nature of Binding Specificity with Receptors.
Allendorph, G.P., Isaacs, M.J., Kawakami, Y., Izpisua Belmonte, J.C., Choe, S.
Biochemistry. (2007) 46:12238-12247. [link]

144. Development of a European Human Embryonic Stem Cell Registry – hESCreg.
Borstlap J, Kurtz A, Stacey G, Elstner A, Damaschun A, Arán B, Gerlach JC, Izpisua JC, Veiga A
Regenerative Medicine (2007) 3:945-951. [link]

145. Modeling Developmental Asymmetries.
Rasskin-Gutman D, Ibanes M, Izpisua-Belmonte JC.
Modeling Biology: Structures, Behaviors, Evolution, in The Vienna Series in Theoretical Biology (2007) (Laubichler, M.D. and Müller, G.B.), The MIT Press

2006

125. A functional genomics approach to the mode of action of apratoxin A.
Leusch, H., Chanda, S.K., Raya, R.M., DeJesus, P.D., Orth, A.P. Walker, J.R., Izpisua Belmonte, J.C., Schultz, P.
Nature Chemical Biology. (2006) 2:158-167 [link]

126. Maintenance of embryonic stem cell pluripotency by Nanog-mediated reversal of mesoderm specification.
Suzuki, A., Raya, A., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F.H., Rodriguez-Esteban, C., Izpisua Belmonte, J.C.
Nature Clinical Practice Cardiovascular Medicine. (2006) 3:S114-S122 [link]

127. Vertebrate left-right asymmetry: a convergence of divergences.
Raya, A., Izpisua Belmonte, J.C.
Nature Reviews Genetics. (2006) 7:283-293 [link]

128. High resolution episcopic microscopy: a rapid technique for high detailed 3D analysis of gene activity in the context of tissue architecture and morphology.
Weninger, W.J., Geyer, S.H., Mohun, T.J., Rasskin-Gutman, D., Matsui, T., Ribeiro, I., Costa, L., Izpisua Belmonte, J.C., Muller, G. B.
Anatomy and Embryology. (2006) 211:213-221 [link]

129. Understanding embryonic heart development as a tool for cardiac cell based therapy.
Soler-Botija, C., Cervera, R.P., Oishi, I., Raya, R.M., Dubova, I., Rodriguez-Esteban, C., Izpisua Belmonte, J.C.
Annals of Pediatrics. (2006) 64:15-22 [link]

130. Nanog binds to Smad1 and blocks BMP-induced differentiation of embryonic stem cells.
Suzuki, A., Raya, A., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F.H., Rodriguez-Esteban, C., and Izpisua Belmonte, J.C.
PNAS. (2006) 103:10294-10299 [link]

131. Cell lineage transport: a mechanism for molecular gradient formation.
Ibanes, M., Rasskin-Gutman, D., Kawakami, Y., and Izpisua Belmonte, J.C.
Nature Molecular Systems Biology. (2006) 2:57 [link]

132. Regulation of primary cilia formation and left-right patterning in zebrafish by duboraya, a novel mediator of non-canonical Wnt signaling.
Oishi, I., Kawakami, Y., Raya, A., Callol-Massot, C., Izpisua Belmonte, J.C.
Nature Genetics. (2006) 38:1316-1322 [link]

133. The role of TGFbs and Sox9 during limb chondrogenesis.
Kawakami, Y., Rodriguez-Leon, J., Izpisua Belmonte, J.C.
Current Opinion in Cell Biology. (2006) 18:723-729 [link]

134. Wnt/beta-catenin signaling regulates vertebrate limb regeneration.
Kawakami, Y., Rodriguez Esteban, C., Raya, M., Kawakami, H., Marti, M., Dubova, I., and Izpisua Belmonte, J.C.
Genes and Development. (2006) 20:3232-3237. [link]

135. Left-right asymmetry in humans.
Raya, A., Izpisua Belmonte, J.C.
Encyclopedia of Life Sciences (2006) John Wiley & Sons, Ltd: Chichester

136. Selection of embryos for stem cell derivation: can we optimize the process?
Veiga, A., Vicenta Camarasa, M., Aran, B., Izpisua, J.C.
Stem Cells in Reproductive Medicine: Basic Science and Therapeutic Potential. (2006) (Pellicer and Simon, Ed.)

2005

115. Nodal Cilia Dynamics and the Specification of the Left/Right Axis in Early Embryo Development.
Buceta, J., Ibanes, M., Rasskin-Gutman, D., Okada, Y., Hirokawa, N., and Izpisua Belmonte, J.C.
Biophysical Journal. (2005) 89:2199-2209. [link]

116. Non-canonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development.
Matsui, T., Raya, A., Kawakami, Y., Callol, C., Capdevila, J., Rodriguez-Esteban, C., and Izpisua Belmonte, J.C.
Genes and Development. (2005) 19:164-175 [link]

117. Transcriptional co-activator PGC-1 regulates chondrogenesis via association with Sox 9.
Kawakami, Y., Tsuda, M., Takahashi, S., Taniguchi, N., Rodriguez-Esteban, C., Zemmyo, M., Furumatsu, T., Lotz, M., Izpisua Belmonte, J.C. and Asahara, H.
PNAS. (2005) 102: 2414-2419 [link]

118. Expression of Fgf19 in the developing eye.
Francisco-Morcillo, J., Sanchez-Calderon, H., Kawakami, Y., Izpisua Belmonte, J.C., Hidalgo-Sanchez, M., Martin-Partido, G.
Developmental Brain Research. (2005) 156:104-109 [link]

119. A Novel Field Approach to 3D Gene Expression Pattern Characterization.
Da Fontoura Costa, L., Travencolo, B.A.N., Azeredo, A., Beletti, M.E., Rasskin-Gutman, D., Sternik, G., Izpisua Belmonte, J.C., Ibanes, M., and Muller, G.
Applied Physics Letters. (2005) 86: 143901-143903 [link]

120. Zebrafish IkB kinase 1 (Ikk1) negatively regulates NF-kB activity.
Correa, R., Matsui, T., Tergaonkar, V., Rodriguez-Esteban, C., Izpisua Belmonte, J.C., Verma, I.
Current Biology. (2005) 15: 1291-1295 [link]

121. Retinoic acid signaling links left-right asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo.
Kawakami, Y., Raya, A., Raya, R.M., Rodriguez-Esteban, C., Izpisua Belmonte, J.C.
Nature. (2005) 435: 165-171 [link]

122. Mechanism of Ciliated Organ Flow: a Conserved Symmetry Breaking Event in Left-Right Axis Determination.
Okada, Y., Takeda, S., Tanaka Y., Izpisua Belmonte, J.C., and Hirokawa, N.
Cell. (2005) 121:633-644 [link]

123. Epicardial RXRa is required for myocardial growth and coronary artery formation.
Merki, E., Zamora, M., Raya, A., Kawakami, Y., Zhang, X., Burch, J., Kubalak, S., Kaliman, P., Izpisua Belmonte, J.C., Chien, K., Ruiz-Lozano, P.
PNAS. (2005) 102:18455-18460 [link]

124. Induction of ectopic limb outgrowth in chick with FGF-8.
Raya, A., Rodriguez Esteban, C. and Izpisua Belmonte, J.C.
Key Experiments for Practical Developmental Biology (2005) (Marî-Beffa, M. & J. Knight, Ed.), Cambridge University Press. pp. 99-105.

2004

102. Notch activity acts as a sensor for extracellular calcium during vertebrate left-right determination.
Raya, A., Kawakami, Y., Rodriguez-Esteban, C., Ibañes, M., Rasskin-Gutman, D., Rodriguez-León, J., Büscher, D., Feijó, J.A. and Izpisua Belmonte, J.C.
Nature. (2004) 427:121-128. [link]

103. Notch promotes epithelial-mesenchymal transitions during heart development and transformation.
Timmerman, L.A., Grego-Bessa, J., Bertrán, E., Pérez-Pomares, J.M., Diez, J., Aranda, S., Palomo, S., Raya, A., McCormick, F., Izpisua Belmonte, J.C. and de la Pompa, J.L.
Genes and Development. (2004) 18(1):99-115[link]

104. PPARg signaling exacerbates mammary gland tumor development.
Saez, E., Rosenfeld, J., Livolsi, A., Lombardo, E., Olson, P., Nelson,M., Banayo, E., Cardiff, R.D., Izpisua Belmonte, J.C. and Evans, R.M.
Genes and Development. (2004) 18(5):528-540. [link]

105. Theoretical morphology developmental asymmetries.
Rasskin-Gutman, D. and Izpisua Belmonte, J.C.
BioEssays. (2004) 26(4):405-412. [link]

106. Characterization of dermacan, a novel zebrafish lectican gene, expressed in dermal bones.
Kang, J.S., Oohashi, T., Kawakami, Y., Bekku, Y., Izpisua Belmonte, J.C. and Ninomiya, Y.
Mechanisms of Development. (2004) 121(3):301-312. [link]

107. Identification of p53 regulators by genome-wide functional analysis.
Huang Q, Raya A, DeJesus P, Chao SH, Quon KC, Caldwell JS, Chanda SK, Izpisua-Belmonte JC, Schultz PG.
Proc. Natl. Acad. Sci. USA. (2004) 101(10):3456-3461. [link]

108. Notochord differentiation by the T-box gene ntl in zebrafish is regulated by NFkb.
Correa, R., Tergaonkar, V., Ng, J., Izpisua-Belmonte, J.C., and Verma, I.
Molecular Cell Biology. (2004) 24(12):5257-5268. [link]

109. Sequential transfer of left-right information during vertebrate embryo development.
Raya, A. and Izpisua Belmonte, J.C.
Curr. Op. Gen. and Dev. (2004) 14:575-581[link]

110. Unveiling the establishment of left-right asymmetry in the chick embryo.
Raya, A. and Izpisua Belmonte, J.C.
Mech. Dev. (2004) 121:1043-1054. [link]

111. Sp8 and Sp9 regulate Fgf8 expression and limb outgrowth in vertebrate embryos.
Kawakami, Y., Rodriguez Esteban, C., Matsui, T., Rodriguez-Leon, J., Kato, S. and Izpisua Belmonte, J.C.
Development. (2004) 31:4763-4774. [link]

112. The zebrafish as a model of heart regeneration.
Raya, A., Consiglio, A., Kawakami, Y., Rodriguez-Esteban, C., and Izpisua-Belmonte, J.C.
Cloning and Stem Cells. (2004) 6(4):345-351[link]

113. Embryos at the core of life.
Rasskin-Gutman, D. and Izpisua Belmonte, J.C.
Development (2004) 130: 5564-5566. [link]

114. Cardiac laterality and congenital heart disease.
Ruiz-Lozano, P., Raya, A., Chien, K.R. and Izpisua Belmonte, J.C.
Molecular Basis of Cardiovascular Disease, 2nd Edition (2004) (Lenehan, A., Ed.), Elsevier. pp. 238-248.

2003

96. MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb.
Kawakami, Y., Rodriguez-Leon, J., Koth, C.M., Büscher, D., Itoh, T., Raya, A., Ng, J.K., Rodriguez Esteban, C., Takahashi, S., Henrique, D., Schwarz, M.F., Asahara, H. and Izpisua Belmonte, J.C.
Nature Cell Biology (2003) 5:513-519. [link]

97. Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos.
Raya, A., Kawakami, Y., Rodriguez-Esteban, C., Büscher, D., Koth, C.M., Itoh, T., Morita, M., Raya, R.M., Dubova, I., Grego Bessa, J., de la Pompa, J.L. and Izpisua Belmonte, J.C.
Genes Dev. (2003) 17:1213-1218. [link]

98. Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein.
Groppe, J., Greenwald, J., Wiater, E., Rodriguez-Leon, J., Economides, A.N., Kwiatkowski, W., Baban, K., Affolter, M., Vale, W.W., Izpisua Belmonte, J.C. and Choe, S.
The Jnl. of Bone and Joint Surgery (2003) 85-A, Suppl. 3:52-58. [link]

99. Activation of Notch signaling pathway precedes heart regeneration in zebrafish.
Raya, A., Koth, C.M., Büscher, D., Kawakami, Y., Itoh, T., Raya, R.M., Sternik, G., Tsai, H.-J., Rodriguez-Esteban, C. and Izpisua Belmonte, J.C.
Proc. Natl. Acad. Sci. USA, Special Supplement on Stem Cells and the Future of Regenerative Medicine. (2003) 100:11889-11895. [link]

100. Differentiation of embryonic stem cells into cardiomyocytes.
Raya, A., Büscher, D., Kawakami, Y., Schwarz, M.-F and Izpisua Belmonte, J.C.
Mesenchymal Stem Cells: Biology and Potential Clinical Uses (2003) (Ministerio de Sanidad Y Consumo, Ed.), Fundacion Valenciana de Estudios Avanzados, pp. 105-119.

101. Control of left-right (L/R) determination in vertebrates by the Hedgehog signaling pathway.
Capdevila, J. and Izpisua Belmonte, J.C.
Handbook of Cell Signaling (2003) (Bradshaw, R. and E. Dennis, Ed.), Elsevier Science. pp. 799-803.

2002

2001

81. Wnt signals control FGF-dependent limb initiation and AER induction in the chick embryo.
Kawakami, Y., Capdevila, J., Büscher, D., Itoh, T., Rodriguez-Esteban, C., and Izpisua Belmonte, J.C.
Cell (2001) 104:891-900. [link]

82. Development of the limb neuromuscular system.
Sharma, K. and Izpisua Belmonte, J.C.
Curr. Opin. Cell Biol. (2001) 13:204-210. [link]

83. Wnt signaling and PKA control Nodal expression and left-right determination in the chick embryo.
Rodriguez-Esteban, C., Capdevila, J., Kawakami, Y. and Izpisua Belmonte, J.C.
Development (2001) 128:3189-3195. [link]

84. Developmental expression of chick Twist and its regulation during limb patterning.
Tavares, A.T., Izpisua Belmonte, J.C. and Rodriguez-Leon, J.
Intl. Jnl. of Dev. Biol. (2001) 45:707-713. [link]

85. Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse.
Mukhopadhyay, M., Shtrom, S., Rodriguez-Esteban, C., Chen, L., Tsukui, T., Gomer, L., Dorward, D.W., Glinka, A., Grinberg, A., Huang, S.-P., Niehrs, C., Izpisua Belmonte, J.C. and Westphal, H.
Developmental Cell (2001) 1:423-434. [link]

86. Cómo distingue el cuerpo la izquierda de la derecha?
Rodriguez-Esteban, C., Raya, A., Capdevila, J. and Izpisua Belmonte, J.C.
Investigacion y Ciencia (2001) 300:62-69. [link]

87. Patterning mechanisms controlling vertebrate limb development.
Capdevila, J. and Izpisua Belmonte, J.C.
Ann. Rev. Cell Dev. Biol. (2001) 17:87-132. [link]

88. Perspectives on the evolutionary origin of tetrapod limbs.
Capdevila, J. and Izpisua Belmonte, J.C.
The Character Concept in Evolutionary Biology (2001) (Wagner, G.P., Ed.), Academic Press, CA, pp. 531-558.

89. Regulation of nodal in the chick by Caronte, FGF8 and Wnt8c.
Izpisua Belmonte, J.C., Rodriguez-Esteban, C. and Capdevila, J.
Axis Formation in Vertebrate Embryos: a Comparative Approach (2001) (Altman, J.S. and C. Coath, Ed.), Human Frontier Science Program, pp. 168-175.

90. Insights into the molecular basis of vertebrate forelimb and hindlimb identity.
Kawakami, Y., Tsukui, T., Ng, J.K., and Izpisua Belmonte, J.C.
Patterning in Vertebrate Development: Frontiers in Molecular Biology (2001) (C. A. Tickle, Ed.), Oxford University Press, pp. 198-213.

2000

1999

48. Outgrowth and patterning of the vertebrate limb. Molecular and cellular basis of pattern formation during vertebrate limb development.
Ng, J.K., Tamura, K., Büscher, D. and Izpisua Belmonte, J.C.
Current Topics in Dev. Biol. (1999) 41:37-66. [link]

49. Sonic Hedgehog (shh) expression in developing and regenerating Axolotl limbs.
Torok, M.A., Gardiner, D.M., Izpisua Belmonte, J.C. and Bryant, S.V.
J. of Exp. Zool. (1999) 284:197-206. [link]

50. Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development.
Szeto, D.P., Rodriguez-Esteban, C., Ryan, A.K., O'Connell, S.M., Liu, F., Kioussi, C., Gleiberman, A.S., Izpisua Belmonte, J.C. and Rosenfeld, M.G.
Genes Dev. (1999) 13:484-494. [link]

51. Spatially and temporally-restricted expression of two T-box genes during zebrafish embryogenesis.
Yonei-Tamura, S., Tamura, K., Tsukui, T. and Izpisua Belmonte, J.C.
Mech. Dev. (1999) 80:219-221. [link]

52. Conservation of the expression and function of apterous orthologs in Drosophila and mammals.
Rincon-Limas, D.E., Lu, C.-H., Canal, I., Calleja, M., Rodriguez Esteban, C., Izpisua Belmonte, J.C. and Botas, J.
Proc. Natl. Acad. Sci. USA (1999) 96:2165-2170. [link]

53. Muscle development during vertebrate limb outgrowth.
Büscher, D. and Izpisua Belmonte, J.C.
Cell & Tissue Res. (1999) 296:131-139. [link]

54. The T-Box genes Tbx4 and Tbx5 regulate limb outgrowth and identity.
Rodriguez-Esteban, C., Tsukui, T., Yonei, S., Magallon, J., Tamura, K. and Izpisua Belmonte, J.C.
Nature (1999) 398:814-818. [link]

55. IKK1-deficient mice exhibit abnormal development of skin and skeleton.
Li, Q., Lu, Q., Hwang, J.Y., Büscher, D., Lee, K.-F., Izpisua Belmonte, J.C. and Verma, I.M.
Genes Dev. (1999) 13:1322-1328. [link]

56. How the body tells left from right.
Izpisua Belmonte, J.C.
Scientific American (1999) 280:46-51. [link]

57. Control of digit formation by activin signalling.
Merino, R., Macias, D., Gañan, Y., Rodriguez-Leon, J., Economides, A.N., Rodriguez-Esteban, C., Izpisua Belmonte, J.C. and Hurle, J.M.
Development (1999) 126:2161-2170. [link]

58. Extracellular modulation of the Hedgehog,Wnt and TGF-b signalling pathways during embryonic development.
Capdevila, J. and Izpisua Belmonte, J.C.
Curr. Opin. Genet. Dev. (1999) 9:427-433. [link]

59. Origin and development of the avian tongue muscles.
Huang, R., Zhi, Q., Izpisua Belmonte, J.C., Christ, B. and Ketan, P.
Anat. Embryol. (1999) 200:137-152. [link]

60. RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.
Bach, I., Rodriguez-Esteban, C., Carriere, C., Bhushan, A., Krones, A., Rose, D.W., Glass, C.K., Andersen, B., Izpisua Belmonte, J.C. and Rosenfeld, M.G.
Nature Genet. (1999) 22:394-399. [link]

61. DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development.
Garcia-Domingo, D., Leonardo, E., Grandien, A., Martinez, P., Albar, J.P., Izpisua Belmonte, J.C. and Martinez-A., C.
Proc. Natl. Acad. Sci. USA (1999) 96:7992-7997. [link]

62. Dysregulation of trace element composition in ovariectomized cynomolgus monkey bones.
Yamada, G., Nakamura, S., Fukuzaki, K., Izumi, H., Horai, N., Nagata, R., Minami, T., Tohno, Y., Suzuki, K., Haraguchi, R., Miyado, K., Toyoda, T., Izpisua Belmonte, J.C., Maruyama, I. and Kitajima, I.
Cell. & Mol. Biol. (1999) 44:1205-1213. [link]

63. The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry.
Rodriguez-Esteban, C., Capdevila, J., Economides, A.N., Pascual, J., Ortiz, A. and Izpisua Belmonte, J.C.
Nature (1999) 401:243-251. [link]

64. Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis.
Lin, C.R., Kioussi, C., O’Connell, S., Briata, P., Szeto, D., Liu, F., Izpisua Belmonte, J.C. and Rosenfeld, M.G.
Nature (1999) 401:279-282. [link]

65. Transcription factors during limb development.
Tavares, A., Capdevila, J. and Izpisua Belmonte, J.C.
Scientific American (Sp. edit.) (1999) 4, 30-32

66. Multiple left-right asymmetry defects in Shh-/- mutant mice unveil a convergence of the Shh and Retinoic Acid pathways in the control of Lefty-1.
Tsukui, T., Capdevila, J., Tamura, K., Ruiz-Lozano, P., Rodriguez-Esteban, C., Yonei-Tamura, S., Magallon, J., Chandraratna, R.A.S., Chien, K., Blumberg, B., Evans, R.M. and Izpisua Belmonte, J.C.
Proc. Natl. Acad. Sci. USA (1999) 96:11376-11381. [link]

67. Molecular basis of left-right asymmetry.
Tamura, K., Yonei-Tamura, S. and Izpisua Belmonte, J.C.
Dev. Growth Differ. (1999) 41:645-656. [link]

68. Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin.
Capdevila, J., Tsukui, T., Rodriguez-Esteban, C., Zappavigna, V. and Izpisua Belmonte, J.C.
Mol. Cell (1999) 4: 839-849. [link]

69. Differential expression of Tbx4 and Tbx5 in Zebrafish fin buds.
Tamura, K., Yonei-Tamura, S. and Izpisua Belmonte, J.C.
Mech. Dev. (1999) 87:181-184. [link]

70. Subtractive hybridization and construction of cDNA libraries.
Blumberg, B. and Izpisua Belmonte, J.C.
Molecular Embryology: Methods and Protocols (1999) (Sharpe, P.T. and I. Mason, Ed.), Humana Press, N.J., Vol. 97:555-574.

71. Differential display of eukaryotic mRNA.
Tugores-Cester, A. and Izpisua Belmonte, J. C.
Molecular Embryology: Methods and Protocols (1999) (Sharpe, P.T. and I., Mason, Ed.), Humana Press, N.J., Vol. 97:575-590.

1998

40. Role of Rel/NF-KB transcription factors during the outgrowth of the vertebrate limb.
Kanegae, Y., Tavares, A.T., Izpisua Belmonte, J.C. and Verma, I.M.
Nature (1998) 392:611-614. [link]

41. Molecular architecture of the vertebrate limb.
Capdevila, J., Rodriguez-Esteban, C. and Izpisua Belmonte, J. C.
Scientific American (1998) 12: 23-37 (Sp. edit.). [link]

42. Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud.
Kengaku, M., Capdevila, J., Rodriguez-Esteban, C., De La Peña, J., Johnson, R.L., Izpisua Belmonte, J.C. and Tabin, C.J.
Science (1998) 280:1274-1277. [link]

43. Tbx genes and limb identity in chick embryo development.
Isaac, A., Rodriguez-Esteban, C., Ryan, A., Altabef, M., Tsukui, T., Patel, K., Tickle, C. and Izpisua Belmonte, J.C.
Development (1998) 125:1867-1875. [link]

44. Limbs are moving…where are they going?
Schwabe, J.W.R., Rodriguez-Esteban, C. and Izpisua Belmonte, J.C.
Trends in Genetics (1998) 14:229-235. [link]

45. Pitx2 determines left-right asymmetry of internal organs in vertebrates.
Ryan, A., Blumberg, B., Rodriguez-Esteban, C., Yonei-Tamura, S., Tamura, K., Tsukui, T., De La Peña, J., Sabbagh, W., Greenwald, J., Choe, S., Norris, D.P., Robertson, E.J., Evans, R.M., Rosenfeld, M.G. and Izpisua Belmonte, J.C.
Nature (1998) 394:545-551. [link]

46. Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth.
Rodriguez-Esteban, C., Schwabe, J.W.R., De La Peña, J., Rincon-Limas, D.E., Magallon, J., Botas, J. and Izpisua Belmonte, J.C.
Development (1998) 125:3925-3934. [link]

47. The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb outgrowth.
Takahashi, M., Tamura, K., Büscher, D., Masuya, H., Yonei-Tamura, S., Matsumoto, K., Naitoh-Matsuo, M., Takeuchi, J., Ogura, K., Shiroishi, T., Ogura, T. and Izpisua Belmonte, J.C.
Development (1998) 125:4417-4425. [link]

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Juan Carlos Izpisua Belmonte

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