2020

Zhang, W., Qu, J., Liu, G.H., Belmonte, J.C.I. The ageing epigenome and its rejuvenation. (2020) Nature Reviews Molecular Cell biology. DOI: 10.1038/s41580-019-0204-5

Prieto, J., Ponsoda, X., Belmonte, J.C.I., Torres, J. Mitochondrial dynamics and metabolism in induced pluripotency. (2020) Experimental Gerontology.:110870 DOI: 10.1016/j.exger.2020.110870

Conner, C., Lager, T.W., Guldner, I.H., Wu, M.Z., Hishida, Y., Hishida, T., Ruiz, S., Yamasaki, A.E., Gilson, R.C., Belmonte, J.C.I., Gray, P.C., Kelber, J.A., Zhang, S., Panopoulos, A.D. Cell surface GRP78 promotes stemness in normal and neoplastic cells. (2020) Scientific Reports. 10(1):3474. DOI: 10.1038/s41598-020-60269-y

Ma, S., Sun, S., Geng, L., Song, M., Wang, W., Ye, Y., Ji, Q., Zou, Z., Wang, S., He, X., Li, W., Esteban, C.R., Long, X., Guo, G., Chan, P., Zhou, Q., Belmonte, J.C.I., Zhang, W., Qu, J., Liu, G.H. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. (2020) Cell. DOI: 10.1016/j.cell.2020.02.008

Martinez-Redondo, P., Guillen-Guillen, I., Davidsohn, N., Wang, C., Prieto, J., Kurita, M., Hatanaka, F., Zhong, C., Hernandez-Benitez, R., Hishida, T., Lezaki, T., Sakamoto, A., Nemeth, A.N., Hishida, Y., Esteban, C.R., Shojima, K., Huang, L., Shokhirev, M., Nuñez-Delicado, E., Campistol, J.M., Guillen-Vicente, I., Rodriguez-Iñigo, E., Lopez-Alcorocho, J.M., Guillen-Vicente, M., Church, G., Reddy, P., Guillen-Garcia, P., Liu, G.H., Belmonte, J.C.I. αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model. (2020) Protein & Cell. DOI: 10.1007/s13238-019-00685-7

Wang, S., Zheng, Y., Li, J., Yu, Y., Zhang, W., Song, M., Liu, Z., Min, Z., Hu, H., Jing, Y., He, X., Sun, L., Ma, L., Esteban, C.R., Chan, P., Qiao, J., Zhou, Q., Izpisua Belmonte, J.C., Qu, J., Tang, F., Liu, G.H. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. (2020) Cell. DOI: 10.1016/j.cell.2020.01.009

2019

Wu, C.J., Cho, S., Huang, H.Y., Lu, C.H., Russ, J., Cruz, L.O., da Cunha, F.F., Chen, M.C., Lin, L.L., Warner, L.M., Liao, H.K., Utzschneider, D.T., Quon, S., Berner, J., Camara, N.O.S., Zehn, D., Belmonte, J.C.I., Chen, L.C., Huang, S.F., Kuo, M.L., Lu, L.F. MiR-23~27~24-mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation. (2019) Science Advances. 5(12):eaaw1715. DOI: 10.1126/sciadv.aaw1715

Niu, Y., Sun, N., Li, C., Lei, Y., Huang, Z., Wu, J., Si, C., Dai, X., Liu, C., Wei, K., Liu, L., Feng, S., Kang, Y., Si, W., Wang, H., Zhang, E., Zhao, L., Li, Z., Luo, X., Cui, G., Izpisúa Belmonte, J.C., Ji, W., Tan, T. Dissecting primate early post-implantation development using long-term in vitro embryo culture (2019) Science. DOI: 10.1126/science.aaw5754

Li, R., Zhong, C., Yu, Y., Liu, H., Sakurai, M., Yu, L., Min, Z., Shi, L., Wei, Y., Takahashi, Y., Liao, H.K., Qiao, J., Deng, H., Nuñez-Delicado, E., Rodriguez Esteban, C., Wu, J., Izpisua Belmonte, J.C. Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures. (2019) Cell. 179(3):687-702.e18. DOI: 10.1016/j.cell.2019.09.029

Xia, Y., Izpisua Belmonte, J.C. Design Approaches for Generating Organ Constructs. (2019) Cell Stem Cell. 25(3):447. DOI: 10.1016/j.stem.2019.08.001

Martinez, C.A., Cambra, J.M., Parrilla, I., Lucas, X., Rodriguez-Martinez, H., Martinez, E.A., Izpisua, J.C., Cuello, C., Gil, M.A. Three-to-5-day weaning-to-estrus intervals do not affect neither efficiency of collection nor in vitro developmental ability of in vivo-derived pig zygotes. (2019) Theriogenology. 141:48-53. DOI: 10.1016/j.theriogenology.2019.09.004

Zhang, Y., Li, T., Preissl, S., Amaral, M.L., Grinstein, J.D., Farah, E.N., Destici, E., Qiu, Y., Hu, R., Lee, A.Y., Chee, S., Ma, K., Ye, Z., Zhu, Q., Huang, H., Fang, R., Yu, L., Izpisua Belmonte, J.C., Wu, J., Evans, S.M., Chi, N.C., Ren, B. Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. (2019) Nature Genetics. DOI: 10.1038/s41588-019-0479-7

Suzuki, K., Yamamoto, M., Hernandez-Benitez, R., Li, Z., Wei, C., Soligalla, R.D., Aizawa, E., Hatanaka, F., Kurita, M., Reddy, P., Ocampo, A., Hishida, T., Sakurai, M., Nemeth, A.N., Nuñez Delicado, E., Campistol, J.M., Magistretti, P., Guillen, P., Rodriguez Esteban, C., Gong, J., Yuan, Y., Gu, Y., Liu, G.H., López-Otín, C., Wu, J., Zhang, K., Izpisua Belmonte, J.C. Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction. (2019) Cell Research. DOI: 10.1038/s41422-019-0213-0

Low, J.H., Li, P., Chew, E.G.Y., Zhou, B., Suzuki, K., Zhang, T., Lian, M.M., Liu, M., Aizawa, E., Rodriguez Esteban, C., Yong, K.S.M., Chen, Q., Campistol, J.M., Fang, M., Khor, C.C., Foo, J.N., Izpisua Belmonte, J.C., Xia, Y. Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network. (2019) Cell Stem Cell. DOI: 10.1016/j.stem.2019.06.009

Deng, L., Ren, R., Liu, Z., Song, M., Li, J., Wu, Z., Ren, X., Fu, L., Li, W., Zhang, W., Guillen, P., Izpisua Belmonte, J.C., Chan, P., Qu, J., Liu, G.H. Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. (2019) Nature Communications. 10(1):3329. DOI: 10.1038/s41467-019-10831-8

Xia, Y., Izpisua Belmonte, J.C. Design Approaches for Generating Organ Constructs. (2019) Cell Stem Cell. 24(6):877-894. DOI: 10.1016/j.stem.2019.05.016

Zhong, C., Wu, J., Izpisua Belmonte, J.C. Pig Chimeric Model with Human Pluripotent Stem Cells. (2019) Methods in Molecular Biology. 2005:101-124. DOI: 10.1007/978-1-4939-9524-0_8

Memczak, S., Shao, Y., Izpisua Belmonte, J.C. Towards precise, safe genome editing. (2019) Cell Research. DOI: 10.1038/s41422-019-0188-x

Kurita, M., Izpisua Belmonte, J.C., Suzuki, K., Okazaki, M. Development of de novo epithelialization method for treatment of cutaneous ulcers. (2019) Journal of Dermatological Science. DOI: 10.1016/j.jdermsci.2019.06.006

Li, M., Izpisua Belmonte, J.C. Organoids - Preclinical Models of Human Disease. Reply. (2019) New England journal of medicine. 380(20):1982. DOI: 10.1056/NEJMc1903253

Fu, L., Hu, Y., Song, M., Liu, Z., Zhang, W., Yu, F.X., Wu, J., Wang, S., Izpisua Belmonte, J.C., Chan, P., Qu, J., Tang, F., Liu, G.H. Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis. (2019) PLOS Biology. 17(4):e3000201. DOI: 10.1371/journal.pbio.3000201

Martinez-Redondo, P., Izpisua Belmonte, J.C. Tailored chromatin modulation to promote tissue regeneration. (2019) Seminars in Cell & Developmental Biology. DOI: 10.1016/j.semcdb.2019.04.015

Hishida, T., Vazquez-Ferrer, E., Hishida-Nozaki, Y., Sancho-Martinez, I., Takahashi, Y., Hatanaka, F., Wu, J., Ocampo, A., Reddy, P., Wu, M.Z., Gerken, L., Shaw, R.J., Rodriguez Esteban, C., Benner, C., Nakagawa, H., Guillen Garcia, P., Nuñez Delicado, E., Castells, A., Campistol, J.M., Liu, G.H., Izpisua Belmonte, J.C. Mutations in foregut SOX2 cells induce efficient proliferation via CXCR2 pathway. (2019) Protein & Cell. 10(7):485-495. DOI: 10.1007/s13238-019-0630-3

Song, M., Belmonte, J.C.I., Liu, G.H. Age-related cardiopathies gene editing. (2019) Aging. 11(5):1327-1328.. DOI: 10.18632/aging.101853

Grigorian Shamagian, L., Madonna, R., Taylor, D., Climent, A.M., Prosper, F., Bras-Rosario, L., Bayes-Genis, A., Ferdinandy, P., Fernández-Avilés, F., Izpisua Belmonte, J.C., Fuster, V., Bolli, R. Perspectives on Directions and Priorities for Future Preclinical Studies in Regenerative Medicine. (2019) Circulation research. 124(6):938-951. DOI: 10.1161/CIRCRESAHA.118.313795

Li, M., Izpisua Belmonte, J.C. Organoids - Preclinical Models of Human Disease. (2019) New England Journal of Medicine. 380(6):569-579. DOI: 10.1056/NEJMra1806175

Ling, C., Liu, Z., Song, M., Zhang, W., Wang, S., Liu, X., Ma, S., Sun, S., Fu, L., Chu, Q., Belmonte, J.C.I., Wang, Z., Qu, J., Yuan, Y., Liu, G.H. Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells. (2019) Protein & Cell. DOI: 10.1007/s13238-019-0608-1

Beyret, E., Liao, H.K., Yamamoto, M., Hernandez-Benitez, R., Fu, Y., Erikson, G., Reddy, P., Izpisua Belmonte, J.C. Single-dose CRISPR-Cas9 therapy extends lifespan of mice with Hutchinson-Gilford progeria syndrome. (2019) Nature Medicine. DOI: 10.1038/s41591-019-0343-4

Garreta, E., Prado, P., Tarantino, C., Oria, R., Fanlo, L., Martí, E., Zalvidea, D., Trepat, X., Roca-Cusachs, P., Gavaldà-Navarro, A., Cozzuto, L., Campistol, J.M., Izpisúa Belmonte, J.C., Hurtado Del Pozo, C., Montserrat, N. Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells. (2019) Nature Materials. DOI: 10.1038/s41563-019-0287-6

Kang, E., Wu, J., Gutierrez, N.M., Koski, A., Tippner-Hedges, R., Agaronyan, K., Platero-Luengo, A., Martinez-Redondo, P., Ma, H., Lee, Y., Hayama, T., Van Dyken, C., Wang, X., Luo, S., Ahmed, R., Li, Y., Ji, D., Kayali, R., Cinnioglu, C., Olson, S., Jensen, J., Battaglia, D., Lee, D., Wu, D., Huang, T., Wolf, D.P., Temiakov, D., Belmonte, J.C.I., Amato, P., Mitalipov, S. Author Correction: Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. (2019) Nature. DOI: 10.1038/s41586-019-0876-1

Weykopf, B., Haupt, S., Jungverdorben, J., Flitsch, L.J., Hebisch, M., Liu, G., Suzuki, K., Belmonte, J.C.I., Peitz, M., Blaess, S., Till, A., Brüstle, O. Induced pluripotent stem cell-based modeling of mutant LRRK2-associated Parkinson's Disease. (2019) European Journal of Neuroscience. DOI: 10.1111/ejn.14345

Yan, P., Li, Q., Wang, L., Lu, P., Suzuki, K., Liu, Z., Lei, J., Li, W., He, X., Wang, S., Ding, J., Chan, P., Zhang, W., Song, M., Izpisua Belmonte, J.C., Qu, J., Tang, F., Liu, G.H. FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. (2019) Cell Stem Cell. DOI: 10.1016/j.stem.2018.12.002

Zhang, S., Chen, T., Chen, N., Gao, D., Shi, B., Kong, S., West, R.C., Yuan, Y., Zhi, M., Wei, Q., Xiang, J., Mu, H., Yue, L., Lei, X., Wang, X., Zhong, L., Liang, H., Cao, S., Belmonte, J.C.I., Wang, H., Han, J. Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells. (2019) Nature Communications. 10(1):496. DOI: 10.1038/s41467-019-08378-9

Li, Z., Araoka, T., Belmonte, J.C.I. Gene Editing in 3D Cultured Nephron Progenitor Cell Lines. (2019) Methods in Molecular Biology. 1926:151-159. DOI: 10.1007/978-1-4939-9021-4_13

2018

Raya, A., Rodríguez-Pizà, I., Arán, B., Consiglio, A., Barri, P.N., Veiga, A., Izpisúa Belmonte, J.C. Generation of cardiomyocytes from new human embryonic stem cell lines derived from poor-quality blastocysts. (2018) Cold Spring Harbor Symposia on Quantitative Biology. 73:127-35. DOI: 10.1101/sqb.2008.73.038

Hurtado Del Pozo, C., Garreta, E., Izpisúa Belmonte, J.C., Montserrat, N. Modeling epigenetic modifications in renal development and disease with organoids and genome editing. (2018) Disease Models & Mechanisms. 11(11). DOI: 10.1242/dmm.035048

Peng, Q., Lu, S., Shi, Y., Pan, Y., Limsakul, P., Chernov, A.V., Qiu, J., Chai, X., Shi, Y., Wang, P., Ji, Y., Li, Y.J., Strongin, A.Y., Verkhusha, V.V., Izpisua Belmonte, J.C., Ren, B., Wang, Y., Chien, S., Wang, Y. Coordinated histone modifications and chromatin reorganization in a single cell revealed by FRET biosensors. (2018) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1811818115

Kurita, M., Araoka, T., Hishida, T., O'Keefe, D.D., Takahashi, Y., Sakamoto, A., Sakurai, M., Suzuki, K., Wu, J., Yamamoto, M., Hernandez-Benitez, R., Ocampo, A., Reddy, P., Shokhirev, M.N., Magistretti, P., Núñez Delicado, E., Eto, H., Harii, K., Izpisua Belmonte, J.C. In vivo reprogramming of wound-resident cells generates skin epithelial tissue. (2018) Nature. DOI: 10.1038/s41586-018-0477-4

Hong, S.H., Fang, S., Lu, B.C., Nofsinger, R., Kawakami, Y., Castro, G.L., Yin, Y., Lin, C., Yu, R.T., Downes, M., Izpisúa Belmonte, J.C., Shilatifard, A., Evans, R.M. Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis. (2018) Proceedings of the National Academy of Sciences of the United States of America. 115(41):10381-10386. DOI: 10.1073/pnas.1809480115

Marian, A.J., Bhatnagar, A., Bolli, R., Izpisua Belmonte, J.C. Introduction to Cardiovascular Aging Compendium. (2018) Circulation research. 123(7):737-739. DOI: 10.1161/CIRCRESAHA.118.313940

Ma, H., Marti-Gutierrez, N., Park, S.W., Wu, J., Hayama, T., Darby, H., Van Dyken, C., Li, Y., Koski, A., Liang, D., Suzuki, K., Gu, Y., Gong, J., Xu, X., Ahmed, R., Lee, Y., Kang, E., Ji, D., Park, A.R., Kim, D., Kim, S.T., Heitner, S.B., Battaglia, D., Krieg, S.A., Lee, D.M., Wu, D.H., Wolf, D.P., Amato, P., Kaul, S., Belmonte, J.C.I., Kim, J.S., Mitalipov, S. Ma et al. reply. (2018) Nature. 560(7717):E10-E23. DOI: 10.1038/s41586-018-0381-y

Hernandez-Benitez, R., Martinez-Martinez, M.L., Lajara, J., Magistretti, P., Montserrat, N., Izpisua Belmonte, J.C. At the Heart of Genome Editing and Cardiovascular Diseases. (2018) Circulation research. 123(2):221-223. DOI: 10.1161/CIRCRESAHA.118.312676

Niederberger, C., Pellicer, A., Cohen, J., Gardner, D.K., Palermo, G.D., O'Neill, C.L., Chow, S., Rosenwaks, Z., Cobo, A., Swain, J.E., Schoolcraft, W.B., Frydman, R., Bishop, L.A., Aharon, D., Gordon, C., New, E., Decherney, A., Tan, S.L., Paulson, R.J., Goldfarb, J.M., Brännström, M., Donnez, J., Silber, S., Dolmans, M.M., Simpson, J.L., Handyside, A.H., Munné, S., Eguizabal, C., Montserrat, N., Izpisua Belmonte, J.C., Trounson, A., Simon, C., Tulandi, T., Giudice, L.C., Norman, R.J., Hsueh, A.J., Sun, Y., Laufer, N., Kochman, R., Eldar-Geva, T., Lunenfeld, B., Ezcurra, D., D'Hooghe, T., Fauser, B.C.J.M., Tarlatzis, B.C., Meldrum, D.R., Casper, R.F., Fatemi, H.M., Devroey, P., Galliano, D., Wikland, M., Sigman, M., Schoor, R.A., Goldstein, M., Lipshultz, L.I., Schlegel, P.N., Hussein, A., Oates, R.D., Brannigan, R.E., Ross, H.E., Pennings, G., Klock, S.C., Brown, S., Van Steirteghem, A., Rebar, R.W., LaBarbera, A.R. Forty years of IVF. (2018) Fertility and Sterility. 110(2):185-324.e5. DOI: 10.1016/j.fertnstert.2018.06.005

Ren, R., Belmonte, J.C.I., Liu, G.H. Adenine base editing to mimic or correct disease mutations in rodents. (2018) Protein & Cell. DOI: 10.1007/s13238-018-0570-3

Garreta, E., Sanchez, S., Lajara, J., Montserrat, N., Belmonte, J.C.I. Roadblocks in the Path of iPSC to the Clinic. (2018) Current Transplantation Reports. 5(1):14-18. DOI: 10.1007/s40472-018-0177-x

Li, M., Izpisua Belmonte, J.C. Deconstructing the pluripotency gene regulatory network. (2018) Nature Cell Biology. 20(4):382-392. DOI: 10.1038/s41556-018-0067-6

Fleischer, A., Lorenzo, I.M., Palomino, E., Aasen, T., Gómez, F., Servera, M., Asensio, V.J., Gálvez, V., Izpisúa-Belmonte, J.C., Bachiller, D. Generation of two induced pluripotent stem cell (iPSC) lines from p.F508del Cystic Fibrosis patients. (2018) Stem Cell Research. 29:1-5. DOI: 10.1016/j.scr.2018.03.004

Bogliotti, Y.S., Wu, J., Vilarino, M., Okamura, D., Soto, D.A., Zhong, C., Sakurai, M., Sampaio, R.V., Suzuki, K., Izpisua Belmonte, J.C., Ross, P.J. Efficient derivation of stable primed pluripotent embryonic stem cells from bovine blastocysts. (2018) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1716161115

Wu, Z., Zhang, W., Song, M., Wang, W., Wei, G., Li, W., Lei, J., Huang, Y., Sang, Y., Chan, P., Chen, C., Qu, J., Suzuki, K., Belmonte, J.C.I., Liu, G.H. Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. (2018) Protein & Cell. DOI: 10.1007/s13238-018-0517-8

Garreta, E., Montserrat, N., Belmonte, J.C.I. Kidney organoids for disease modeling. (2018) Oncotarget. 9(16):12552-12553. DOI: 10.18632/oncotarget.24438

Beyret, E., Martinez Redondo, P., Platero Luengo, A., Izpisua Belmonte, J.C. Elixir of Life: Thwarting Aging With Regenerative Reprogramming. (2018) Circulation research. 122(1):128-141. DOI: 10.1161/CIRCRESAHA.117.311866

2017

Suzuki, K., Izpisua Belmonte, J.C. In vivo genome editing via the HITI method as a tool for gene therapy. (2017) Journal of Human Genetics. DOI: 10.1038/s10038-017-0352-4

Liao, H.K., Hatanaka, F., Araoka, T., Reddy, P., Wu, M.Z., Sui, Y., Yamauchi, T., Sakurai, M., O'Keefe, D.D., Núñez-Delicado, E., Guillen, P., Campistol, J.M., Wu, C.J., Lu, L.F., Esteban, C.R., Izpisua Belmonte, J.C. In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation. (2017) Cell. DOI: 10.1016/j.cell.2017.10.025

Pei, D., Beier, D.W., Levy-Lahad, E., Marchant, G., Rossant, J., Izpisua Belmonte, J.C., Lovell-Badge, R., Jaenisch, R., Charo, A., Baltimore, D. Human Embryo Editing: Opportunities and Importance of Transnational Cooperation. (2017) Cell Stem Cell. 21(4):423-426. DOI: 10.1016/j.stem.2017.09.010

Wu, J., Vilarino, M., Suzuki, K., Okamura, D., Bogliotti, Y.S., Park, I., Rowe, J., McNabb, B., Ross, P.J., Belmonte, J.C.I. CRISPR-Cas9 mediated one-step disabling of pancreatogenesis in pigs. (2017) Scientific Reports. 7(1):10487. DOI: 10.1038/s41598-017-08596-5

Ren, R., Ocampo, A., Liu, G.H., Izpisua Belmonte, J.C. Regulation of Stem Cell Aging by Metabolism and Epigenetics. (2017) Cell Metabolism. 26(3):460-474. DOI: 10.1016/j.cmet.2017.07.019

Yang, J., Li, J., Suzuki, K., Liu, X., Wu, J., Zhang, W., Ren, R., Zhang, W., Chan, P., Izpisua Belmonte, J.C., Qu, J., Tang, F., Liu, G.H. Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. (2017) Cell Research. 27(9):1178-1181. DOI: 10.1038/cr.2017.86

Yoon, J.H., Mo, J.S., Kim, M.Y., Ann, E.J., Ahn, J.S., Jo, E.H., Lee, H.J., Lee, Y.C., Seol, W., Yarmoluk, S.M., Gasser, T., Kahle, P.J., Liu, G.H., Belmonte, J.C.I., Park, H.S. LRRK2 functions as a scaffolding kinase of ASK1-mediated neuronal cell death. (2017) Biochimica et Biophysica Acta. DOI: 10.1016/j.bbamcr.2017.09.001

Wu, M.Z., Cheng, W.C., Chen, S.F., Nieh, S., O'Connor, C., Liu, C.L., Tsai, W.W., Wu, C.J., Martin, L., Lin, Y.S., Wu, K.J., Lu, L.F., Izpisua Belmonte, J.C. miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS. (2017) Nature Cell Biology. DOI: 10.1038/ncb3615

Hatanaka, F., Ocampo, A., Izpisua Belmonte, J.C. Keeping the Rhythm while Changing the Lyrics: Circadian Biology in Aging. (2017) Cell. 170(4):599-600. DOI: 10.1016/j.cell.2017.07.039

Ma, H., Marti-Gutierrez, N., Park, S.W., Wu, J., Lee, Y., Suzuki, K., Koski, A., Ji, D., Hayama, T., Ahmed, R., Darby, H., Van Dyken, C., Li, Y., Kang, E., Park, A.R., Kim, D., Kim, S.T., Gong, J., Gu, Y., Xu, X., Battaglia, D., Krieg, S.A., Lee, D.M., Wu, D.H., Wolf, D.P., Heitner, S.B., Belmonte, J.C.I., Amato, P., Kim, J.S., Kaul, S., Mitalipov, S. Correction of a pathogenic gene mutation in human embryos. (2017) Nature. 548(7668):413-419. DOI: 10.1038/nature23305

Yamasaki, A.E., Panopoulos, A.D., Belmonte, J.C.I. Understanding the genetics behind complex human disease with large-scale iPSC collections. (2017) Genome Biology. 18(1):135. DOI: 10.1186/s13059-017-1276-1

Li, M., Borrelli, E., Magistretti, P.J., Izpisua Belmonte, J.C., Sassone-Corsi, P., Orlando, V. Gathering by the Red Sea highlights links between environment and epigenetics. (2017) Nature Structural & Molecular Biology. 24(6):491-493. DOI: 10.1038/nsmb.3422

Garreta, E., Prado, P., Izpisua Belmonte, J.C., Montserrat, N. Non-coding microRNAs for cardiac regeneration: Exploring novel alternatives to induce heart healing. (2017) Noncoding RNA Res. 2(2):93-99. DOI: 10.1016/j.ncrna.2017.05.001

Takahashi, Y., Wu, J., Suzuki, K., Martinez-Redondo, P., Li, M., Liao, H.K., Wu, M.Z., Hernández-Benítez, R., Hishida, T., Shokhirev, M.N., Esteban, C.R., Sancho-Martinez, I., Belmonte, J.C.I. Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells. (2017) Science. 356(6337):503-508. DOI: 10.1126/science.aag3260

Gil, M.A., Martinez, C.A., Nohalez, A., Parrilla, I., Roca, J., Wu, J., Ross, P.J., Cuello, C., Izpisua, J.C., Martinez, E.A. Developmental competence of porcine genome-edited zygotes. (2017) Molecular Reproduction and Development. DOI: 10.1002/mrd.22829

Yokoyama, S., Furukawa, S., Kitada, S., Mori, M., Saito, T., Kawakami, K., Belmonte, J.C.I., Kawakami, Y., Ito, Y., Sato, T., Asahara, H. Analysis of transcription factors expressed at the anterior mouse limb bud. (2017) PLOS One. 12(5):e0175673. DOI: 10.1371/journal.pone.0175673

Wang, L., Yi, F., Fu, L., Yang, J., Wang, S., Wang, Z., Suzuki, K., Sun, L., Xu, X., Yu, Y., Qiao, J., Belmonte, J.C.I., Yang, Z., Yuan, Y., Qu, J., Liu, G.H. CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs. (2017) Protein & Cell. 8(5):365-378. DOI: 10.1007/s13238-017-0397-3

Panopoulos, A.D., D'Antonio, M., Benaglio, P., Williams, R., Hashem, S.I., Schuldt, B.M., DeBoever, C., Arias, A.D., Garcia, M., Nelson, B.C., Harismendy, O., Jakubosky, D.A., Donovan, M.K.R., Greenwald, W.W., Farnam, K., Cook, M., Borja, V., Miller, C.A., Grinstein, J.D., Drees, F., Okubo, J., Diffenderfer, K.E., Hishida, Y., Modesto, V., Dargitz, C.T., Feiring, R., Zhao, C., Aguirre, A., McGarry, T.J., Matsui, H., Li, H., Reyna, J., Rao, F., O'Connor, D.T., Yeo, G.W., Evans, S.M., Chi, N.C., Jepsen, K., Nariai, N., Müller, F.J., Goldstein, L.S.B., Izpisua Belmonte, J.C., Adler, E., Loring, J.F., Berggren, W.T., D'Antonio-Chronowska, A., Smith, E.N., Frazer, K.A. iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types. (2017) Stem Cell Reports. 8(4):1086-1100. DOI: 10.1016/j.stemcr.2017.03.012

Panopoulos, A.D., D'Antonio, M., Benaglio, P., Williams, R., Hashem, S.I., Schuldt, B.M., DeBoever, C., Arias, A.D., Garcia, M., Nelson, B.C., Harismendy, O., Jakubosky, D.A., Donovan, M.K., Greenwald, W.W., Farnam, K., Cook, M., Borja, V., Miller, C.A., Grinstein, J.D., Drees, F., Okubo, J., Diffenderfer, K.E., Hishida, Y., Modesto, V., Dargitz, C.T., Feiring, R., Zhao, C., Aguirre, A., McGarry, T.J., Matsui, H., Li, H., Reyna, J., Rao, F., O'Connor, D.T., Yeo, G.W., Evans, S.M., Chi, N.C., Jepsen, K., Nariai, N., Müller, F.J., Goldstein, L.S., Izpisua Belmonte, J.C., Adler, E., Loring, J.F., Berggren, W.T., D'Antonio-Chronowska, A., Smith, E.N., Frazer, K.A. iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types. (2017) Stem Cell Reports. DOI: 10.1016/j.stemcr.2017.03.012

Panopoulos, A.D., Smith, E.N., Arias, A.D., Shepard, P.J., Hishida, Y., Modesto, V., Diffenderfer, K.E., Conner, C., Biggs, W., Sandoval, E., D'Antonio-Chronowska, A., Berggren, W.T., Izpisua Belmonte, J.C., Frazer, K.A. Aberrant DNA Methylation in Human iPSCs Associates with MYC-Binding Motifs in a Clone-Specific Manner Independent of Genetics. (2017) Cell Stem Cell. 20(4):505-517.e6. DOI: 10.1016/j.stem.2017.03.010

Yang, Y., Liu, B., Xu, J., Wang, J., Wu, J., Shi, C., Xu, Y., Dong, J., Wang, C., Lai, W., Zhu, J., Xiong, L., Zhu, D., Li, X., Yang, W., Yamauchi, T., Sugawara, A., Li, Z., Sun, F., Li, X., Li, C., He, A., Du, Y., Wang, T., Zhao, C., Li, H., Chi, X., Zhang, H., Liu, Y., Li, C., Duo, S., Yin, M., Shen, H., Belmonte, J.C., Deng, H. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. (2017) Cell. 169(2):243-257.e25. DOI: 10.1016/j.cell.2017.02.005

Li, M., Belmonte, J.C. Ground rules of the pluripotency gene regulatory network. (2017) Nature Reviews. Genetics. 18(3):180-191. DOI: 10.1038/nrg.2016.156

Wu, J., Platero-Luengo, A., Sakurai, M., Sugawara, A., Gil, M.A., Yamauchi, T., Suzuki, K., Bogliotti, Y.S., Cuello, C., Morales Valencia, M., Okumura, D., Luo, J., Vilariño, M., Parrilla, I., Soto, D.A., Martinez, C.A., Hishida, T., Sánchez-Bautista, S., Martinez-Martinez, M.L., Wang, H., Nohalez, A., Aizawa, E., Martinez-Redondo, P., Ocampo, A., Reddy, P., Roca, J., Maga, E.A., Esteban, C.R., Berggren, W.T., Nuñez Delicado, E., Lajara, J., Guillen, I., Guillen, P., Campistol, J.M., Martinez, E.A., Ross, P.J., Izpisua Belmonte, J.C. Interspecies Chimerism with Mammalian Pluripotent Stem Cells. (2017) Cell. 168(3):473-486.e15. DOI: 10.1016/j.cell.2016.12.036

2016

Ocampo, A., Reddy, P., Martinez-Redondo, P., Platero-Luengo, A., Hatanaka, F., Hishida, T., Li, M., Lam, D., Kurita, M., Beyret, E., Araoka, T., Vazquez-Ferrer, E., Donoso, D., Roman, J.L., Xu, J., Rodriguez Esteban, C., Nuñez, G., Nuñez Delicado, E., Campistol, J.M., Guillen, I., Guillen, P., Izpisua Belmonte, J.C. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. (2016) Cell. 167(7):1719-1733.e12. DOI: 10.1016/j.cell.2016.11.052

Kang, E., Wu, J., Gutierrez, N.M., Koski, A., Tippner-Hedges, R., Agaronyan, K., Platero-Luengo, A., Martinez-Redondo, P., Ma, H., Lee, Y., Hayama, T., Van Dyken, C., Wang, X., Luo, S., Ahmed, R., Li, Y., Ji, D., Kayali, R., Cinnioglu, C., Olson, S., Jensen, J., Battaglia, D., Lee, D., Wu, D., Huang, T., Wolf, D.P., Temiakov, D., Belmonte, J.C., Amato, P., Mitalipov, S. Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. (2016) Nature. 540(7632):270-275. DOI: 10.1038/nature20592

Wu, J., Greely, H.T., Jaenisch, R., Nakauchi, H., Rossant, J., Belmonte, J.C. Stem cells and interspecies chimaeras. (2016) Nature. 540(7631):51-59. DOI: 10.1038/nature20573

Suzuki, K., Tsunekawa, Y., Hernandez-Benitez, R., Wu, J., Zhu, J., Kim, E.J., Hatanaka, F., Yamamoto, M., Araoka, T., Li, Z., Kurita, M., Hishida, T., Li, M., Aizawa, E., Guo, S., Chen, S., Goebl, A., Soligalla, R.D., Qu, J., Jiang, T., Fu, X., Jafari, M., Esteban, C.R., Berggren, W.T., Lajara, J., Nuñez-Delicado, E., Guillen, P., Campistol, J.M., Matsuzaki, F., Liu, G.H., Magistretti, P., Zhang, K., Callaway, E.M., Zhang, K., Belmonte, J.C. In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. (2016) Nature. 540(7631):144-149. DOI: 10.1038/nature20565

Garreta, E., Marco, A., Izpisua Belmonte, J.C., Montserrat, N. Genome editing in human pluripotent stem cells: a systematic approach unrevealing pancreas development and disease. (2016) Stem Cell Investigation. 3:76. DOI: 10.21037/sci.2016.10.11

Saito, R., Rocanin-Arjo, A., You, Y.H., Darshi, M., Van Espen, B., Miyamoto, S., Pham, J., Pu, M., Romoli, S., Natarajan, L., Ju, W., Kretzler, M., Nelson, R., Ono, K., Thomasova, D., Mulay, S.R., Ideker, T., D'Agati, V., Beyret, E., Belmonte, J.C., Anders, H.J., Sharma, K. Systems biology analysis reveals role of MDM2 in diabetic nephropathy. (2016) JCI Insight. 1(17):e87877. DOI: 10.1172/jci.insight.87877

Wu, J., Platero Luengo, A., Gil, M.A., Suzuki, K., Cuello, C., Morales Valencia, M., Parrilla, I., Martinez, C.A., Nohalez, A., Roca, J., Martinez, E.A., Izpisua Belmonte, J.C. Generation of human organs in pigs via interspecies blastocyst complementation. (2016) Reproduction in Domestic Animals. 51 Suppl 2:18-24. DOI: 10.1111/rda.12796

Li, Z., Araoka, T., Wu, J., Liao, H.K., Li, M., Lazo, M., Zhou, B., Sui, Y., Wu, M.Z., Tamura, I., Xia, Y., Beyret, E., Matsusaka, T., Pastan, I., Rodriguez Esteban, C., Guillen, I., Guillen, P., Campistol, J.M., Izpisua Belmonte, J.C. 3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors. (2016) Cell Stem Cell. 19(4):516-529. DOI: 10.1016/j.stem.2016.07.016

Izpisúa Belmonte, J.C. Human Organs from Animal Bodies. (2016) Sci. Am. 315(5):32-37. DOI: 10.1038/scientificamerican1116-32

Wu, J., Ocampo, A., Izpisua Belmonte, J.C. Cellular Metabolism and Induced Pluripotency. (2016) Cell. 166(6):1371-85. DOI: 10.1016/j.cell.2016.08.008

Li, M., Izpisua Belmonte, J.C. Looking to the future following 10 years of induced pluripotent stem cell technologies. (2016) Nature Protocols. 11(9):1579-85. DOI: 10.1038/nprot.2016.108

Sancho-Martinez, I., Izpisua Belmonte, J.C. Reprogramming strategies for the establishment of novel human cancer models. (2016) Cell Cycle. 15(18):2393-7. DOI: 10.1080/15384101.2016.1196305

Eguizabal, C., Herrera, L., De Oñate, L., Montserrat, N., Hajkova, P., Izpisua Belmonte, J.C. Characterization of the Epigenetic Changes During Human Gonadal Primordial Germ Cells Reprogramming. (2016) Stem Cells. 34(9):2418-28. DOI: 10.1002/stem.2422

Montserrat, N., Garreta, E., Izpisua Belmonte, J.C. Regenerative strategies for kidney engineering. (2016) FEBS Journal. 283(18):3303-24. DOI: 10.1111/febs.13704

Féron, F., Gepner, B., Lacassagne, E., Stephan, D., Mesnage, B., Blanchard, M.P., Boulanger, N., Tardif, C., Devèze, A., Rousseau, S., Suzuki, K., Izpisua Belmonte, J.C., Khrestchatisky, M., Nivet, E., Erard-Garcia, M. Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders. (2016) Molecular Psychiatry. 21(9):1215-24. DOI: 10.1038/mp.2015.106

Ocampo, A., Reddy, P., Izpisua Belmonte, J.C. Anti-Aging Strategies Based on Cellular Reprogramming. (2016) Trends in Molecular Medicine. 22(8):725-38. DOI: 10.1016/j.molmed.2016.06.005

Garreta, E., de Oñate, L., Fernández-Santos, M.E., Oria, R., Tarantino, C., Climent, A.M., Marco, A., Samitier, M., Martínez, E., Valls-Margarit, M., Matesanz, R., Taylor, D.A., Fernández-Avilés, F., Izpisua Belmonte, J.C., Montserrat, N. Myocardial commitment from human pluripotent stem cells: Rapid production of human heart grafts. (2016) Biomaterials. 98:64-78. DOI: 10.1016/j.biomaterials.2016.04.003

Wu, J., Izpisua Belmonte, J.C. Stem Cells: A Renaissance in Human Biology Research. (2016) Cell. 165(7):1572-1585. DOI: 10.1016/j.cell.2016.05.043

Wu, J., Izpisua Belmonte, J.C. Interspecies chimeric complementation for the generation of functional human tissues and organs in large animal hosts. (2016) Transgenic Res. 25(3):375-84. DOI: 10.1007/s11248-016-9930-z

Wu, J., Yamauchi, T., Izpisua Belmonte, J.C. An overview of mammalian pluripotency. (2016) Development. 143(10):1644-8. DOI: 10.1242/dev.132928

Krause, M.N., Sancho-Martinez, I., Izpisua Belmonte, J.C. Understanding the molecular mechanisms of reprogramming. (2016) Biochemical and Biophysical Research Communications. 473(3):693-7. DOI: 10.1016/j.bbrc.2015.11.120

Suzuki, A., Hirasaki, M., Hishida, T., Wu, J., Okamura, D., Ueda, A., Nishimoto, M., Nakachi, Y., Mizuno, Y., Okazaki, Y., Matsui, Y., Izpisua Belmonte, J.C., Okuda, A. Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells. (2016) Nature Communications. 7:11056. DOI: 10.1038/ncomms11056

Wu, J., Belmonte, J.C.I. The Molecular Harbingers of Early Mammalian Embryo Patterning. (2016) Cell. 165(1):13-15. DOI: 10.1016/j.cell.2016.03.005

Fu, L., Xu, X., Ren, R., Wu, J., Zhang, W., Yang, J., Ren, X., Wang, S., Zhao, Y., Sun, L., Yu, Y., Wang, Z., Yang, Z., Yuan, Y., Qiao, J., Izpisua Belmonte, J.C., Qu, J., Liu, G.H. Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs. (2016) Protein & Cell. 7(3):210-21. DOI: 10.1007/s13238-016-0244-y

Sancho-Martinez, I., Nivet, E., Xia, Y., Hishida, T., Aguirre, A., Ocampo, A., Ma, L., Morey, R., Krause, M.N., Zembrzycki, A., Ansorge, O., Vazquez-Ferrer, E., Dubova, I., Reddy, P., Lam, D., Hishida, Y., Wu, M.Z., Esteban, C.R., O'Leary, D., Wahl, G.M., Verma, I.M., Laurent, L.C., Izpisua Belmonte, J.C. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. (2016) Nature Communications. 7:10743. DOI: 10.1038/ncomms10743

Beyret, E., Izpisua Belmonte, J.C. The XEN of reprogramming. (2016) Cell Research. 26(2):147-8. DOI: 10.1038/cr.2016.9

Li, M., Izpisua Belmonte, J.C. Mending a Faltering Heart. (2016) Circulation research. 118(2):344-51. DOI: 10.1161/CIRCRESAHA.115.306820

2015

Duan, S., Yuan, G., Liu, X., Ren, R., Li, J., Zhang, W., Wu, J., Xu, X., Fu, L., Li, Y., Yang, J., Zhang, W., Bai, R., Yi, F., Suzuki, K., Gao, H., Esteban, C.R., Zhang, C., Izpisua Belmonte, J.C., Chen, Z., Wang, X., Jiang, T., Qu, J., Tang, F., Liu, G.H. PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. (2015) Nature Communications. 6:10068. DOI: 10.1038/ncomms10068

Wu, J., Izpisua Belmonte, J.C. Metabolic exit from naive pluripotency. (2015) Nature Cell Biology. 17(12):1519-21. DOI: 10.1038/ncb3269

Brennand, K.J., Marchetto, M.C., Benvenisty, N., Brüstle, O., Ebert, A., Izpisua Belmonte, J.C., Kaykas, A., Lancaster, M.A., Livesey, F.J., McConnell, M.J., McKay, R.D., Morrow, E.M., Muotri, A.R., Panchision, D.M., Rubin, L.L., Sawa, A., Soldner, F., Song, H., Studer, L., Temple, S., Vaccarino, F.M., Wu, J., Vanderhaeghen, P., Gage, F.H., Jaenisch, R. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. (2015) Stem Cell Reports. 5(6):933-45. DOI: 10.1016/j.stemcr.2015.10.011

Jiménez, G., López-Ruiz, E., Kwiatkowski, W., Montañez, E., Arrebola, F., Carrillo, E., Gray, P.C., Izpisua Belmonte, J.C., Choe, S., Perán, M., Marchal, J.A. Activin A/BMP2 chimera AB235 drives efficient redifferentiation of long term cultured autologous chondrocytes. (2015) Scientific Reports. 5:16400. DOI: 10.1038/srep16400

Wu, J., Izpisua Belmonte, J.C. Dynamic Pluripotent Stem Cell States and Their Applications. (2015) Cell Stem Cell. 17(5):509-25. DOI: 10.1016/j.stem.2015.10.009

Wu, M.Z., Chen, S.F., Nieh, S., Benner, C., Ger, L.P., Jan, C.I., Ma, L., Chen, C.H., Hishida, T., Chang, H.T., Lin, Y.S., Montserrat, N., Gascon, P., Sancho-Martinez, I., Izpisua Belmonte, J.C. Hypoxia Drives Breast Tumor Malignancy through a TET-TNFα-p38-MAPK Signaling Axis. (2015) Cancer Research. 75(18):3912-24. DOI: 10.1158/0008-5472.CAN-14-3208

Ma, H., Folmes, C.D., Wu, J., Morey, R., Mora-Castilla, S., Ocampo, A., Ma, L., Poulton, J., Wang, X., Ahmed, R., Kang, E., Lee, Y., Hayama, T., Li, Y., Van Dyken, C., Gutierrez, N.M., Tippner-Hedges, R., Koski, A., Mitalipov, N., Amato, P., Wolf, D.P., Huang, T., Terzic, A., Laurent, L.C., Izpisua Belmonte, J.C., Mitalipov, S. Metabolic rescue in pluripotent cells from patients with mtDNA disease. (2015) Nature. 524(7564):234-8. DOI: 10.1038/nature14546

Kamaid, A., Molina-Villa, T., Mendoza, V., Pujades, C., Maldonado, E., Ispizua Belmonte, J.C., López-Casillas, F. Betaglycan knock-down causes embryonic angiogenesis defects in zebrafish. (2015) Genesis. DOI: 10.1002/dvg.22876

Hashem, S.I., Perry, C.N., Bauer, M., Han, S., Clegg, S.D., Ouyang, K., Deacon, D.C., Spinharney, M., Panopoulos, A.D., Izpisua Belmonte, J.C., Frazer, K.A., Chen, J., Gong, Q., Zhou, Z., Chi, N.C., Adler, E.D. Brief Report: Oxidative Stress Mediates Cardiomyocyte Apoptosis in a Human Model of Danon Disease and Heart Failure. (2015) Stem Cells. 33(7):2343-50. DOI: 10.1002/stem.2015

Liao, H.K., Li, M., Martinez Martinez, L., Izpisua Belmonte, J.C. Stem cell, CRISPR and HIV. (2015) Cell Cycle. 14(13):1991-2. DOI: 10.1080/15384101.2015.1046791

Zhang, W., Li, J., Suzuki, K., Qu, J., Wang, P., Zhou, J., Liu, X., Ren, R., Xu, X., Ocampo, A., Yuan, T., Yang, J., Li, Y., Shi, L., Guan, D., Pan, H., Duan, S., Ding, Z., Li, M., Yi, F., Bai, R., Wang, Y., Chen, C., Yang, F., Li, X., Wang, Z., Aizawa, E., Goebl, A., Soligalla, R.D., Reddy, P., Esteban, C.R., Tang, F., Liu, G.H., Belmonte, J.C. Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. (2015) Science. 348(6239):1160-3. DOI: 10.1126/science.aaa1356

Izpisua Belmonte, J.C., Callaway, E.M., Caddick, S.J., Churchland, P., Feng, G., Homanics, G.E., Lee, K.F., Leopold, D.A., Miller, C.T., Mitchell, J.F., Mitalipov, S., Moutri, A.R., Movshon, J.A., Okano, H., Reynolds, J.H., Ringach, D., Sejnowski, T.J., Silva, A.C., Strick, P.L., Wu, J., Zhang, F. Brains, genes, and primates. (2015) Neuron. 86(3):617-31. DOI: 10.1016/j.neuron.2015.03.021

Wu, J., Okamura, D., Li, M., Suzuki, K., Luo, C., Ma, L., He, Y., Li, Z., Benner, C., Tamura, I., Krause, M.N., Nery, J.R., Du, T., Zhang, Z., Hishida, T., Takahashi, Y., Aizawa, E., Kim, N.Y., Lajara, J., Guillen, P., Campistol, J.M., Esteban, C.R., Ross, P.J., Saghatelian, A., Ren, B., Ecker, J.R., Izpisua Belmonte, J.C. An alternative pluripotent state confers interspecies chimaeric competency. (2015) Nature. 521(7552):316-21. DOI: 10.1038/nature14413

Ding, Z., Sui, L., Ren, R., Liu, Y., Xu, X., Fu, L., Bai, R., Yuan, T., Hao, Y., Zhang, W., Pan, H., Liu, W., Yu, H., Esteban, C.R., Yu, X., Yang, Z., Li, J., Wang, X., Izpisua Belmonte, J.C., Liu, G.H., Yi, F., Qu, J. A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells. (2015) Protein & Cell. 6(5):386-9. DOI: 10.1007/s13238-014-0117-1

Reddy, P., Ocampo, A., Suzuki, K., Luo, J., Bacman, S.R., Williams, S.L., Sugawara, A., Okamura, D., Tsunekawa, Y., Wu, J., Lam, D., Xiong, X., Montserrat, N., Esteban, C.R., Liu, G.H., Sancho-Martinez, I., Manau, D., Civico, S., Cardellach, F., Del Mar O'Callaghan, M., Campistol, J., Zhao, H., Campistol, J.M., Moraes, C.T., Izpisua Belmonte, J.C. Selective elimination of mitochondrial mutations in the germline by genome editing. (2015) Cell. 161(3):459-69. DOI: 10.1016/j.cell.2015.03.051

Kurian, L., Aguirre, A., Sancho-Martinez, I., Benner, C., Hishida, T., Nguyen, T.B., Reddy, P., Nivet, E., Krause, M.N., Nelles, D.A., Esteban, C.R., Campistol, J.M., Yeo, G.W., Belmonte, J.C.I. Identification of novel long noncoding RNAs underlying vertebrate cardiovascular development. (2015) Circulation. 131(14):1278-1290. DOI: 10.1161/CIRCULATIONAHA.114.013303

Ocampo, A., Izpisua Belmonte, J.C. Stem cells. Holding your breath for longevity. (2015) Science. 347(6228):1319-20. DOI: 10.1126/science.aaa9608

Liao, H.K., Gu, Y., Diaz, A., Marlett, J., Takahashi, Y., Li, M., Suzuki, K., Xu, R., Hishida, T., Chang, C.J., Esteban, C.R., Young, J., Izpisua Belmonte, J.C. Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells. (2015) Nature Communications. 6:6413. DOI: 10.1038/ncomms7413

Deng, L., Ren, R., Wu, J., Suzuki, K., Izpisua Belmote, J.C., Liu, G.H. CRISPR/Cas9 and TALE: beyond cut and paste. (2015) Protein & Cell. 6(3):157-159. DOI: 10.1007/s13238-015-0137-5

Wang, L., Wu, J., Fang, W., Liu, G.H., Izpisua Belmonte, J.C. Regenerative medicine: targeted genome editing in vivo. (2015) Cell Research. 25(3):271-2. DOI: 10.1038/cr.2015.11

Hishida, T., Nakachi, Y., Mizuno, Y., Katano, M., Okazaki, Y., Ema, M., Takahashi, S., Hirasaki, M., Suzuki, A., Ueda, A., Nishimoto, M., Hishida-Nozaki, Y., Vazquez-Ferrer, E., Sancho-Martinez, I., Izpisua Belmonte, J.C., Okuda, A. Functional compensation between Myc and PI3K signaling supports self-renewal of embryonic stem cells. (2015) Stem Cells. 33(3):713-25. DOI: 10.1002/stem.1893

Hansson, M.L., Albert, S., González Somermeyer, L., Peco, R., Mejía-Ramírez, E., Montserrat, N., Izpisua Belmonte, J.C. Efficient delivery and functional expression of transfected modified mRNA in human embryonic stem cell-derived retinal pigmented epithelial cells. (2015) Journal of Biological Chemistry. 290(9):5661-72. DOI: 10.1074/jbc.M114.618835

Li, M., Izpisua Belmonte, J.C. Roles for noncoding RNAs in cell-fate determination and regeneration. (2015) Nature Structural & Molecular Biology. 22(1):2-4. DOI: 10.1038/nsmb.2946

Krause, M.N., Sancho-Martinez, I., Izpisua Belmonte, J.C. RE: stem cells loaded with multimechanistic oncolytic herpes simplex virus variants for brain tumor therapy. (2015) J. Natl. Cancer Inst. 107(1):368. DOI: 10.1093/jnci/dju368

2014

Wu, J., Izpisua Belmonte, J.C. Stem cells: A designer's guide to pluripotency. (2014) Nature. 516(7530):172-3. DOI: 10.1038/516172a

Aguirre, A., Montserrat, N., Zacchigna, S., Nivet, E., Hishida, T., Krause, M.N., Kurian, L., Ocampo, A., Vazquez-Ferrer, E., Rodriguez-Esteban, C., Kumar, S., Moresco, J.J., Yates, J.R., Campistol, J.M., Sancho-Martinez, I., Giacca, M., Izpisua Belmonte, J.C. In vivo activation of a conserved microRNA program induces mammalian heart regeneration. (2014) Cell Stem Cell. 15(5):589-604. DOI: 10.1016/j.stem.2014.10.003

Xia, Y., Sancho-Martinez, I., Nivet, E., Rodriguez Esteban, C., Campistol, J.M., Izpisua Belmonte, J.C. The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells. (2014) Nature Protocols. 9(11):2693-704. DOI: 10.1038/nprot.2014.182

Pulecio, J., Nivet, E., Sancho-Martinez, I., Vitaloni, M., Guenechea, G., Xia, Y., Kurian, L., Dubova, I., Bueren, J., Laricchia-Robbio, L., Belmonte, J.C.I. Conversion of human fibroblasts into monocyte-like progenitor cells. (2014) Stem Cells. 32(11):2923-2938. DOI: 10.1002/stem.1800

Sancho-Martinez, I., Ocampo, A., Izpisua Belmonte, J.C. Reprogramming by lineage specifiers: blurring the lines between pluripotency and differentiation. (2014) Current Opinion in Genetics & Development. 28:57-63. DOI: 10.1016/j.gde.2014.09.009

Zhu, X., Fu, L., Yi, F., Liu, G.H., Ocampo, A., Qu, J., Izpisua Belmonte, J.C. Regeneration: making muscle from hPSCs. (2014) Cell Research. 24(10):1159-61. DOI: 10.1038/cr.2014.91

Beyret, E., Izpisua Belmonte, J.C. Worming toward transdifferentiation, one (Epigenetic) step at a time. (2014) Developmental Cell. 30(6):641-2. DOI: 10.1016/j.devcel.2014.09.003

Liu, G.H., Suzuki, K., Li, M., Qu, J., Montserrat, N., Tarantino, C., Gu, Y., Yi, F., Xu, X., Zhang, W., Ruiz, S., Plongthongkum, N., Zhang, K., Masuda, S., Nivet, E., Tsunekawa, Y., Soligalla, R.D., Goebl, A., Aizawa, E., Kim, N.Y., Kim, J., Dubova, I., Li, Y., Ren, R., Benner, C., Del Sol, A., Bueren, J., Trujillo, J.P., Surralles, J., Cappelli, E., Dufour, C., Esteban, C.R., Belmonte, J.C.I. Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs. (2014) Nature Communications. 5:4330. DOI: 10.1038/ncomms5330

Suzuki, K., Yu, C., Qu, J., Li, M., Yao, X., Yuan, T., Goebl, A., Tang, S., Ren, R., Aizawa, E., Zhang, F., Xu, X., Soligalla, R.D., Chen, F., Kim, J., Kim, N.Y., Liao, H.K., Benner, C., Esteban, C.R., Jin, Y., Liu, G.H., Li, Y., Izpisua Belmonte, J.C. Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones. (2014) Cell Stem Cell. 15(1):31-6. DOI: 10.1016/j.stem.2014.06.016

Masuda, S., Izpisua Belmonte, J.C. A recipe for targeted therapy in prostate cancer. (2014) Nature Reviews. Urology. 11(7):419. DOI: 10.1038/nrurol.2013.110-c1

Wu, K., Ren, R., Su, W., Wen, B., Zhang, Y., Yi, F., Qiao, X., Yuan, T., Wang, J., Liu, L., Izpisua Belmonte, J.C., Liu, G.H., Chen, C. A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation. (2014) Journal of Biological Chemistry. 289(29):20193-9. DOI: 10.1074/jbc.C114.561860

Uzarski, J.S., Xia, Y., Belmonte, J.C., Wertheim, J.A. New strategies in kidney regeneration and tissue engineering. (2014) Curr. Opin. Nephrol. Hypertens. 23(4):399-405. DOI: 10.1097/01.mnh.0000447019.66970.ea

Wu, M.Z., Li, M., Liu, G.H., Izpisua Belmonte, J.C. A chemical approach to "rewire" neural progenitor cells. (2014) Cell Research. 24(6):641-2. DOI: 10.1038/cr.2014.51

Morris, R., Sancho-Martinez, I., Sharpee, T.O., Izpisua Belmonte, J.C. Mathematical approaches to modeling development and reprogramming. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(14):5076-82. DOI: 10.1073/pnas.1317150111

Costa, R., Arrigoni, G., Cozza, G., Lolli, G., Battistutta, R., Izpisua Belmonte, J.C., Pinna, L.A., Sarno, S. The lysine-specific demethylase 1 is a novel substrate of protein kinase CK2. (2014) Biochimica et Biophysica Acta. 1844(4):722-9. DOI: 10.1016/j.bbapap.2014.01.014

Masuda, S., Izpisua Belmonte, J.C. Re: Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer. (2014) J. Natl. Cancer Inst. 106(3):djt457. DOI: 10.1093/jnci/djt457

Li, M., Izpisua Belmonte, J.C. Ageing: Genetic rejuvenation of old muscle. (2014) Nature. 506(7488):304-5. DOI: 10.1038/nature13058

Li, M., Suzuki, K., Kim, N.Y., Liu, G.H., Izpisua Belmonte, J.C. A cut above the rest: targeted genome editing technologies in human pluripotent stem cells. (2014) Journal of Biological Chemistry. 289(8):4594-9. DOI: 10.1074/jbc.R113.488247

Fu, L., Zhu, X., Yi, F., Liu, G.H., Izpisua Belmonte, J.C. Regenerative medicine: transdifferentiation in vivo. (2014) Cell Research. 24(2):141-2. DOI: 10.1038/cr.2013.165

Navarro, S., Moleiro, V., Molina-Estevez, F.J., Lozano, M.L., Chinchon, R., Almarza, E., Quintana-Bustamante, O., Mostoslavsky, G., Maetzig, T., Galla, M., Heinz, N., Schiedlmeier, B., Torres, Y., Modlich, U., Samper, E., Río, P., Segovia, J.C., Raya, A., Güenechea, G., Izpisua-Belmonte, J.C., Bueren, J.A. Generation of iPSCs from genetically corrected Brca2 hypomorphic cells: implications in cell reprogramming and stem cell therapy. (2014) Stem Cells. 32(2):436-46. DOI: 10.1002/stem.1586

Gu, Y., Liu, G.H., Plongthongkum, N., Benner, C., Yi, F., Qu, J., Suzuki, K., Yang, J., Zhang, W., Li, M., Montserrat, N., Crespo, I., Del Sol, A., Esteban, C.R., Zhang, K., Izpisua Belmonte, J.C. Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes. (2014) Protein & Cell. 5(1):59-68. DOI: 10.1007/s13238-013-0016-x

Zhang, K., Liu, G.H., Yi, F., Montserrat, N., Hishida, T., Esteban, C.R., Izpisua Belmonte, J.C. Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors. (2014) Protein & Cell. 5(1):48-58. DOI: 10.1007/s13238-013-0011-2

Yang, J., Cai, N., Yi, F., Liu, G.H., Qu, J., Izpisua Belmonte, J.C. Gating pluripotency via nuclear pores. (2014) Trends in Molecular Medicine. 20(1):1-7. DOI: 10.1016/j.molmed.2013.10.003

Xu, X.L., Yang, J.P., Fu, L.N., Ren, R.T., Yi, F., Suzuki, K., Liu, K., Ding, Z.C., Qu, J., Zhang, W.Q., Li, Y., Yuan, T.T., Yuan, G.H., Sui, L.N., Guan, D., Duan, S.L., Pan, H.Z., Wang, P., Zhu, X.P., Montserrat, N., Li, M., Bai, R.J., Liu, L., Izpisua Belmonte, J.C., Liu, G.H. Direct reprogramming of porcine fibroblasts to neural progenitor cells. (2014) Protein & Cell. 5(1):4-7. DOI: 10.1007/s13238-013-0015-y

Vitaloni, M., Pulecio, J., Bilic, J., Kuebler, B., Laricchia-Robbio, L., Izpisua Belmonte, J.C. MicroRNAs contribute to induced pluripotent stem cell somatic donor memory. (2014) Journal of Biological Chemistry. 289(4):2084-98. DOI: 10.1074/jbc.M113.538702

Esquivies, L., Blackler, A., Peran, M., Rodriguez-Esteban, C., Izpisua Belmonte, J.C., Booker, E., Gray, P.C., Ahn, C., Kwiatkowski, W., Choe, S. Designer nodal/BMP2 chimeras mimic nodal signaling, promote chondrogenesis, and reveal a BMP2-like structure. (2014) Journal of Biological Chemistry. 289(3):1788-97. DOI: 10.1074/jbc.M113.529180

2013

Xia, Y., Nivet, E., Sancho-Martinez, I., Gallegos, T., Suzuki, K., Okamura, D., Wu, M.Z., Dubova, I., Esteban, C.R., Montserrat, N., Campistol, J.M., Izpisua Belmonte, J.C. Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells. (2013) Nature Cell Biology. 15(12):1507-15. DOI: 10.1038/ncb2872

Zhang, W., Qu, J., Suzuki, K., Liu, G.H., Izpisua Belmonte, J.C. Concealing cellular defects in pluripotent stem cells. (2013) Trends in Cell Biology. 23(12):587-92. DOI: 10.1016/j.tcb.2013.07.001

Marti, M., Montserrat, N., Pardo, C., Mulero, L., Miquel-Serra, L., Rodrigues, A.M., Andrés Vaquero, J., Kuebler, B., Morera, C., Barrero, M.J., Izpisua Belmonte, J.C. M-cadherin-mediated intercellular interactions activate satellite cell division. (2013) Journal of Cell Science. 126(Pt 22):5116-31. DOI: 10.1242/jcs.123562

Aguirre, A., Sancho-Martinez, I., Izpisua Belmonte, J.C. Heart regeneration: a tale of cell reprogramming. (2013) Circulation research. 113(10):1109-11. DOI: 10.1161/CIRCRESAHA.113.302519

Masuda, S., Wu, J., Hishida, T., Pandian, G.N., Sugiyama, H., Izpisua Belmonte, J.C. Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach. (2013) Journal of Molecular Cell Biology. 5(5):354-5. DOI: 10.1093/jmcb/mjt034

Gallegos, T.F., Sancho-Martinez, I., Izpisua Belmonte, J.C. Advances in cellular reprogramming: moving toward a reprieve from immunogenicity. (2013) Immunol. Lett. 155(1-2):14-7. DOI: 10.1016/j.imlet.2013.09.019

Masuda, S., Suzuki, K., Izpisua Belmonte, J.C. Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. (2013) New England Journal of Medicine. 369(12):1171. DOI: 10.1056/NEJMc1308785#SA3

Montserrat, N., Nivet, E., Sancho-Martinez, I., Hishida, T., Kumar, S., Miquel, L., Cortina, C., Hishida, Y., Xia, Y., Esteban, C.R., Izpisua Belmonte, J.C. Reprogramming of human fibroblasts to pluripotency with lineage specifiers. (2013) Cell Stem Cell. 13(3):341-50. DOI: 10.1016/j.stem.2013.06.019

Xu, X., Duan, S., Yi, F., Ocampo, A., Liu, G.H., Izpisua Belmonte, J.C. Mitochondrial regulation in pluripotent stem cells. (2013) Cell Metabolism. 18(3):325-32. DOI: 10.1016/j.cmet.2013.06.005

Gu, Y., Liu, G.H., Plongthongkum, N., Benner, C., Yi, F., Qu, J., Suzuki, K., Yang, J., Zhang, W., Li, M., Montserrat, N., Crespo, I., Del Sol, A., Esteban, C.R., Zhang, K., Belmonte, J.C. Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes. (2013) Protein & Cell. DOI: 10.1007/s13238-013-3911-2

Sancho-Martinez, I., Izpisua Belmonte, J.C. Will SCNT-ESCs be better than iPSCs for personalized regenerative medicine? (2013) Cell Stem Cell. 13(2):141-2. DOI: 10.1016/j.stem.2013.07.013

Wang, P., Qu, J., Wu, M.Z., Zhang, W., Liu, G.H., Izpisua Belmonte, J.C. "TET-on" pluripotency. (2013) Cell Research. 23(7):863-5. DOI: 10.1038/cr.2013.72

Peran, M., Ruiz, S., Kwiatkowski, W., Marchal, J.A., Yang, S.L., Aranega, A., Choe, S., Izpisua Belmonte, J.C. Activin/BMP2 chimeric ligands direct adipose-derived stem cells to chondrogenic differentiation. (2013) Stem Cell Research. 10(3):464-76. DOI: 10.1016/j.scr.2013.02.002

Sesé, B., Barrero, M.J., Fabregat, M.C., Sander, V., Izpisua Belmonte, J.C. SMYD2 is induced during cell differentiation and participates in early development. (2013) Int. J. Dev. Biol. 57(5):357-64. DOI: 10.1387/ijdb.130051ji

Masuda, S., Izpisua Belmonte, J.C. Cotransplantation of MSCs and HSCs. (2013) Transplantation. 95(10):e62-3. DOI: 10.1097/TP.0b013e318290b0b1

Barrero, M.J., Sese, B., Martí, M., Izpisua Belmonte, J.C. Macro histone variants are critical for the differentiation of human pluripotent cells. (2013) Journal of Biological Chemistry. 288(22):16110-6. DOI: 10.1074/jbc.M113.466144

Sui, L., Liu, G.H., Izpisua Belmonte, J.C. hESC-derived pancreatic progenitors. (2013) Cell Research. 23(5):592-4. DOI: 10.1038/cr.2013.20

Nivet, E., Liu, G.H., Montserrat, N., Izpisua Belmonte, J.C. [Resetting Parkinson's disease patient-derived cells to unveil new pathological marks]. (2013) Medecine Sciences. 29(4):353-5. DOI: 10.1051/medsci/2013294006

Masuda, S., Li, M., Izpisua Belmonte, J.C. Niche-less maintenance of HSCs by 2i. (2013) Cell Research. 23(4):458-9. DOI: 10.1038/cr.2013.14

Zhang, K., Yi, F., Liu, G.H., Belmonte, J.C. New march towards the regeneration of sensation and cognition: hear more, see more and learn more. (2013) Journal of Molecular Cell Biology. 5(2):151-3. DOI: 10.1093/jmcb/mjs060

Masuda, S., Izpisua Belmonte, J.C. At the crossroads of targeted treatment and resistance in melanoma. (2013) Lancet Oncol. 14(4):e136-7. DOI: 10.1016/S1470-2045(13)70108-6

Barrero, M.J., Izpisua Belmonte, J.C. Polycomb complex recruitment in pluripotent stem cells. (2013) Nature Cell Biology. 15(4):348-50. DOI: 10.1038/ncb2723

Barrero, M.J., Sese, B., Kuebler, B., Bilic, J., Boue, S., Martí, M., Izpisua Belmonte, J.C. Macrohistone variants preserve cell identity by preventing the gain of H3K4me2 during reprogramming to pluripotency. (2013) Cell Reports. 3(4):1005-11. DOI: 10.1016/j.celrep.2013.02.029

Sander, V., Suñe, G., Jopling, C., Morera, C., Izpisua Belmonte, J.C. Isolation and in vitro culture of primary cardiomyocytes from adult zebrafish hearts. (2013) Nature Protocols. 8(4):800-9. DOI: 10.1038/nprot.2013.041

Aguirre, A., Sancho-Martinez, I., Izpisua Belmonte, J.C. Reprogramming toward heart regeneration: stem cells and beyond. (2013) Cell Stem Cell. 12(3):275-84. DOI: 10.1016/j.stem.2013.02.008

Gu, Y., Yi, F., Liu, G.H., Izpisua Belmonte, J.C. Beating in a dish: new hopes for cardiomyocyte regeneration. (2013) Cell Research. 23(3):314-6. DOI: 10.1038/cr.2012.163

Pan, H., Cai, N., Li, M., Liu, G.H., Izpisua Belmonte, J.C. Autophagic control of cell 'stemness'. (2013) EMBO Molecular Medicine. 5(3):327-31. DOI: 10.1002/emmm.201201999

Masuda, S., Li, M., Izpisua Belmonte, J.C. In vitro generation of platelets through direct conversion: first report in My Knowledge (iMK). (2013) Cell Research. 23(2):176-8. DOI: 10.1038/cr.2012.142

Martí, M., Mulero, L., Pardo, C., Morera, C., Carrió, M., Laricchia-Robbio, L., Esteban, C.R., Izpisua Belmonte, J.C. Characterization of pluripotent stem cells. (2013) Nature Protocols. 8(2):223-53. DOI: 10.1038/nprot.2012.154

Masuda, S., Izpisua Belmonte, J.C. The microenvironment and resistance to personalized cancer therapy. (2013) Nature Reviews. Clinical Oncology. 10(2). DOI: 10.1038/nrclinonc.2012.127-c1

Tiscornia, G., Vivas, E.L., Matalonga, L., Berniakovich, I., Barragán Monasterio, M., Eguizábal, C., Gort, L., González, F., Ortiz Mellet, C., García Fernández, J.M., Ribes, A., Veiga, A., Izpisua Belmonte, J.C. Neuronopathic Gaucher's disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds. (2013) Human Molecular Genetics. 22(4):633-45. DOI: 10.1093/hmg/dds471

Ruiz, S., Gore, A., Li, Z., Panopoulos, A.D., Montserrat, N., Fung, H.L., Giorgetti, A., Bilic, J., Batchelder, E.M., Zaehres, H., Schöler, H.R., Zhang, K., Izpisua Belmonte, J.C. Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming. (2013) Nature Communications. 4:1382. DOI: 10.1038/ncomms2381

Kurian, L., Sancho-Martinez, I., Nivet, E., Aguirre, A., Moon, K., Pendaries, C., Volle-Challier, C., Bono, F., Herbert, J.M., Pulecio, J., Xia, Y., Li, M., Montserrat, N., Ruiz, S., Dubova, I., Rodriguez, C., Denli, A.M., Boscolo, F.S., Thiagarajan, R.D., Gage, F.H., Loring, J.F., Laurent, L.C., Izpisua Belmonte, J.C. Conversion of human fibroblasts to angioblast-like progenitor cells. (2013) Nature Methods. 10(1):77-83. DOI: 10.1038/nmeth.2255

Yi, F., Qu, J., Liu, G.H., Izpisua Belmonte, J.C. The dawn of angiogenesis modeling: regenerating vasculature from human pluripotent stem cells. (2013) Cell Research. 23(1):3-5. DOI: 10.1038/cr.2012.131

Eguizabal, C., Montserrat, N., Veiga, A., Izpisua Belmonte, J.C. Dedifferentiation, transdifferentiation, and reprogramming: future directions in regenerative medicine. (2013) Semin. Reprod. Med. 31(1):82-94. DOI: 10.1055/s-0032-1331802

Sancho-Martinez, I., Izpisua Belmonte, J.C. Stem cells: Surf the waves of reprogramming. (2013) Nature. 493(7432):310-1. DOI: 10.1038/493310b

Nivet, E., Sancho-Martinez, I., Izpisua Belmonte, J.C. Conversion of pericytes to neurons: a new guest at the reprogramming convention. (2013) Stem Cell Res Ther. 4(1):2. DOI: 10.1186/scrt150

2012

Yang, S.L., Harnish, E., Leeuw, T., Dietz, U., Batchelder, E., Wright, P.S., Peppard, J., August, P., Volle-Challier, C., Bono, F., Herbert, J.M., Izpisua Belmonte, J.C. Compound screening platform using human induced pluripotent stem cells to identify small molecules that promote chondrogenesis. (2012) Protein & Cell. 3(12):934-42. DOI: 10.1007/s13238-012-2107-5

Jopling, C., Suñé, G., Faucherre, A., Fabregat, C., Izpisua Belmonte, J.C. Hypoxia induces myocardial regeneration in zebrafish. (2012) Circulation. 126(25):3017-27. DOI: 10.1161/CIRCULATIONAHA.112.107888

Zhang, K., Yi, F., Liu, G.H., Izpisua Belmonte, J.C. Huntington's disease: dancing in a dish. (2012) Cell Research. 22(12):1627-30. DOI: 10.1038/cr.2012.116

Izpisua Belmonte, J.C. Reprogramming development and aging: cell differentiation as a malleable process. (2012) Current Opinion in Cell Biology. 24(6):713-5. DOI: 10.1016/j.ceb.2012.11.006

Liu, G.H., Ding, Z., Izpisua Belmonte, J.C. iPSC technology to study human aging and aging-related disorders. (2012) Current Opinion in Cell Biology. 24(6):765-74. DOI: 10.1016/j.ceb.2012.08.014

Ruiz, S., Panopoulos, A.D., Montserrat, N., Multon, M.C., Daury, A., Rocher, C., Spanakis, E., Batchelder, E.M., Orsini, C., Deleuze, J.F., Izpisua Belmonte, J.C. Generation of a drug-inducible reporter system to study cell reprogramming in human cells. (2012) Journal of Biological Chemistry. 287(48):40767-78. DOI: 10.1074/jbc.M112.384024

Yi, F., Qu, J., Li, M., Suzuki, K., Kim, N.Y., Liu, G.H., Belmonte, J.C. Establishment of hepatic and neural differentiation platforms of Wilson's disease specific induced pluripotent stem cells. (2012) Protein & Cell. 3(11):855-63. DOI: 10.1007/s13238-012-2064-z

Okamura, D., Maeda, I., Taniguchi, H., Tokitake, Y., Ikeda, M., Ozato, K., Mise, N., Abe, K., Noce, T., Izpisua Belmonte, J.C., Matsui, Y. Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. (2012) Genes & Development. 26(22):2477-82. DOI: 10.1101/gad.202242.112

Liu, G.H., Qu, J., Suzuki, K., Nivet, E., Li, M., Montserrat, N., Yi, F., Xu, X., Ruiz, S., Zhang, W., Wagner, U., Kim, A., Ren, B., Li, Y., Goebl, A., Kim, J., Soligalla, R.D., Dubova, I., Thompson, J., Yates, J., Esteban, C.R., Sancho-Martinez, I., Izpisua Belmonte, J.C. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. (2012) Nature. 491(7425):603-7. DOI: 10.1038/nature11557

Ruiz, S., Diep, D., Gore, A., Panopoulos, A.D., Montserrat, N., Plongthongkum, N., Kumar, S., Fung, H.L., Giorgetti, A., Bilic, J., Batchelder, E.M., Zaehres, H., Kan, N.G., Schöler, H.R., Mercola, M., Zhang, K., Izpisua Belmonte, J.C. Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(40):16196-201. DOI: 10.1073/pnas.1202352109

Gu, Y., Liu, G.H., Izpisua Belmonte, J.C. Gametogenesis in a dish. (2012) Cell Research. 22(10):1422-5. DOI: 10.1038/cr.2012.84

Masuda, S., Izpisua Belmonte, J.C. Trametinib for patients with advanced melanoma. (2012) Lancet Oncol. 13(10):e409; author reply e409-10. DOI: 10.1016/S1470-2045(12)70419-9

Sancho-Martinez, I., Baek, S.H., Izpisua Belmonte, J.C. Lineage conversion methodologies meet the reprogramming toolbox. (2012) Nature Cell Biology. 14(9):892-9. DOI: 10.1038/ncb2567

Berniakovich, I., Laricchia-Robbio, L., Izpisua Belmonte, J.C. N-acetylcysteine protects induced pluripotent stem cells from in vitro stress: impact on differentiation outcome. (2012) Int. J. Dev. Biol. 56(9):729-35. DOI: 10.1387/ijdb.120070ji

Camus, S., Quevedo, C., Menéndez, S., Paramonov, I., Stouten, P.F., Janssen, R.A., Rueb, S., He, S., Snaar-Jagalska, B.E., Laricchia-Robbio, L., Izpisua Belmonte, J.C. Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish. (2012) Oncogene. 31(39):4333-42. DOI: 10.1038/onc.2011.594

Willems, E., Cabral-Teixeira, J., Schade, D., Cai, W., Reeves, P., Bushway, P.J., Lanier, M., Walsh, C., Kirchhausen, T., Izpisua Belmonte, J.C., Cashman, J., Mercola, M. Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. (2012) Cell Stem Cell. 11(2):242-52. DOI: 10.1016/j.stem.2012.04.025

Cai, N., Li, M., Qu, J., Liu, G.H., Izpisua Belmonte, J.C. Post-translational modulation of pluripotency. (2012) Journal of Molecular Cell Biology. 4(4):262-5. DOI: 10.1093/jmcb/mjs031

Barrero, M.J., Berdasco, M., Paramonov, I., Bilic, J., Vitaloni, M., Esteller, M., Izpisua Belmonte, J.C. DNA hypermethylation in somatic cells correlates with higher reprogramming efficiency. (2012) Stem Cells. 30(8):1696-702. DOI: 10.1002/stem.1138

Vassena, R., Montserrat, N., Carrasco Canal, B., Aran, B., de Oñate, L., Veiga, A., Izpisua Belmonte, J.C. Accumulation of instability in serial differentiation and reprogramming of parthenogenetic human cells. (2012) Human Molecular Genetics. 21(15):3366-73. DOI: 10.1093/hmg/dds168

Liu, G.H., Li, M., Qu, J., Izpisua Belmonte, J.C. Gating neural development and aging via nuclear pores. (2012) Cell Research. 22(8):1212-4. DOI: 10.1038/cr.2012.35

Li, M., Liu, G.H., Izpisua Belmonte, J.C. Navigating the epigenetic landscape of pluripotent stem cells. (2012) Nature Reviews. Molecular Cell Biology. 13(8):524-35. DOI: 10.1038/nrm3393

Panopoulos, A.D., Belmonte, J.C. Induced pluripotent stem cells in clinical hematology: potentials, progress, and remaining obstacles. (2012) Current Opinion in Hematology. 19(4):256-60. DOI: 10.1097/MOH.0b013e328353c78f

Giorgetti, A., Marchetto, M.C., Li, M., Yu, D., Fazzina, R., Mu, Y., Adamo, A., Paramonov, I., Cardoso, J.C., Monasterio, M.B., Bardy, C., Cassiani-Ingoni, R., Liu, G.H., Gage, F.H., Izpisua Belmonte, J.C. Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(31):12556-61. DOI: 10.1073/pnas.1209523109

Christen, B., Rodrigues, A.M., Monasterio, M.B., Roig, C.F., Izpisua Belmonte, J.C. Transient downregulation of Bmp signalling induces extra limbs in vertebrates. (2012) Development. 139(14):2557-65. DOI: 10.1242/dev.078774

Montserrat, N., Ramírez-Bajo, M.J., Xia, Y., Sancho-Martinez, I., Moya-Rull, D., Miquel-Serra, L., Yang, S., Nivet, E., Cortina, C., González, F., Izpisua Belmonte, J.C., Campistol, J.M. Generation of induced pluripotent stem cells from human renal proximal tubular cells with only two transcription factors, OCT4 and SOX2. (2012) Journal of Biological Chemistry. 287(29):24131-8. DOI: 10.1074/jbc.M112.350413

Liu, G.H., Yi, F., Suzuki, K., Qu, J., Izpisua Belmonte, J.C. Induced neural stem cells: a new tool for studying neural development and neurological disorders. (2012) Cell Research. 22(7):1087-91. DOI: 10.1038/cr.2012.73

Masuda, S., Montserrat, N., Monserrat, N., Okamura, D., Suzuki, K., Izpisua Belmonte, J.C. Cardiosphere-derived cells for heart regeneration. (2012) Lancet. 379(9835):2425-6; author reply 2426-7. DOI: 10.1016/S0140-6736(12)61062-9

Xu, X., Qu, J., Suzuki, K., Li, M., Zhang, W., Liu, G.H., Izpisua Belmonte, J.C. Reprogramming based gene therapy for inherited red blood cell disorders. (2012) Cell Research. 22(6):941-4. DOI: 10.1038/cr.2012.54

Letamendia, A., Quevedo, C., Ibarbia, I., Virto, J.M., Holgado, O., Diez, M., Izpisua Belmonte, J.C., Callol-Massot, C. Development and validation of an automated high-throughput system for zebrafish in vivo screenings. (2012) PLOS One. 7(5):e36690. DOI: 10.1371/journal.pone.0036690

Yi, F., Liu, G.H., Izpisua Belmonte, J.C. Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy. (2012) Protein & Cell. 3(4):246-50. DOI: 10.1007/s13238-012-2918-4

Yi, F., Liu, G.H., Izpisua Belmonte, J.C. Rejuvenating liver and pancreas through cell transdifferentiation. (2012) Cell Research. 22(4):616-9. DOI: 10.1038/cr.2012.33

Jopling, C., Suñe, G., Morera, C., Izpisua Belmonte, J.C. p38α MAPK regulates myocardial regeneration in zebrafish. (2012) Cell Cycle. 11(6):1195-201. DOI: 10.4161/cc.11.6.19637

Liu, G.H., Sancho-Martinez, I., Izpisua Belmonte, J.C. Cut and paste: restoring cellular function by gene correction. (2012) Cell Research. 22(2):283-4. DOI: 10.1038/cr.2011.192

Rodrigues, A.M., Christen, B., Martí, M., Izpisúa Belmonte, J.C. Skeletal muscle regeneration in Xenopus tadpoles and zebrafish larvae. (2012) BMC Developmental Biology. 12:9. DOI: 10.1186/1471-213X-12-9

Panopoulos, A.D., Yanes, O., Ruiz, S., Kida, Y.S., Diep, D., Tautenhahn, R., Herrerías, A., Batchelder, E.M., Plongthongkum, N., Lutz, M., Berggren, W.T., Zhang, K., Evans, R.M., Siuzdak, G., Izpisua Belmonte, J.C. The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming. (2012) Cell Research. 22(1):168-77. DOI: 10.1038/cr.2011.177

Bilic, J., Izpisua Belmonte, J.C. Concise review: Induced pluripotent stem cells versus embryonic stem cells: close enough or yet too far apart? (2012) Stem Cells. 30(1):33-41. DOI: 10.1002/stem.700

Sánchez-Danés, A., Consiglio, A., Richaud, Y., Rodríguez-Pizà, I., Dehay, B., Edel, M., Bové, J., Memo, M., Vila, M., Raya, A., Izpisua Belmonte, J.C. Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and induced pluripotent stem cells. (2012) Human Gene Therapy. 23(1):56-69. DOI: 10.1089/hum.2011.054

Fütterer, A., Raya, A., Llorente, M., Izpisúa-Belmonte, J.C., de la Pompa, J.L., Klatt, P., Martínez-A, C. Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development. (2012) Cell Death and Differentiation. 19(1):132-43. DOI: 10.1038/cdd.2011.62

2011

Sancho-Martinez, I., Nivet, E., Izpisua Belmonte, J.C. The labyrinth of nuclear reprogramming. (2011) Journal of Molecular Cell Biology. 3(6):327-9. DOI: 10.1093/jmcb/mjr031

Tiscornia, G., Vivas, E.L., Izpisúa Belmonte, J.C. Diseases in a dish: modeling human genetic disorders using induced pluripotent cells. (2011) Nature Medicine. 17(12):1570-6. DOI: 10.1038/nm.2504

Li, M., Suzuki, K., Qu, J., Saini, P., Dubova, I., Yi, F., Lee, J., Sancho-Martinez, I., Liu, G.H., Izpisua Belmonte, J.C. Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs. (2011) Cell Research. 21(12):1740-4. DOI: 10.1038/cr.2011.186

Sancho-Martinez, I., Nivet, E., Izpisua Belmonte, J.C. Purging and isolating pluripotent cells, "sweet" dreams become true? (2011) Cell Research. 21(11):1526-7. DOI: 10.1038/cr.2011.163

Kawakami, Y., Marti, M., Kawakami, H., Itou, J., Quach, T., Johnson, A., Sahara, S., O'Leary, D.D., Nakagawa, Y., Lewandoski, M., Pfaff, S., Evans, S.M., Izpisua Belmonte, J.C. Islet1-mediated activation of the β-catenin pathway is necessary for hindlimb initiation in mice. (2011) Development. 138(20):4465-73. DOI: 10.1242/dev.065359

Adamo, A., Barrero, M.J., Izpisua Belmonte, J.C. LSD1 and pluripotency: a new player in the network. (2011) Cell Cycle. 10(19):3215-6. DOI: 10.4161/cc.10.19.17052

Terme, J.M., Sesé, B., Millán-Ariño, L., Mayor, R., Izpisúa Belmonte, J.C., Barrero, M.J., Jordan, A. Histone H1 variants are differentially expressed and incorporated into chromatin during differentiation and reprogramming to pluripotency. (2011) Journal of Biological Chemistry. 286(41):35347-57. DOI: 10.1074/jbc.M111.281923

Montserrat, N., de Oñate, L., Garreta, E., González, F., Adamo, A., Eguizábal, C., Häfner, S., Vassena, R., Izpisua Belmonte, J.C. Generation of feeder-free pig induced pluripotent stem cells without Pou5f1. (2011) Cell Transplantation. 21(5):815-25. DOI: 10.3727/096368911X601019

Vassena, R., Boué, S., González-Roca, E., Aran, B., Auer, H., Veiga, A., Izpisua Belmonte, J.C. Waves of early transcriptional activation and pluripotency program initiation during human preimplantation development. (2011) Development. 138(17):3699-709. DOI: 10.1242/dev.064741

Panopoulos, A.D., Izpisua Belmonte, J.C. Anaerobicizing into pluripotency. (2011) Cell Metabolism. 14(2):143-4. DOI: 10.1016/j.cmet.2011.07.003

Kim, S., Izpisua Belmonte, J.C. Pluripotency of male germline stem cells. (2011) Mol. Cells. 32(2):113-21. DOI: 10.1007/s10059-011-1024-4

Eguizabal, C., Montserrat, N., Vassena, R., Barragan, M., Garreta, E., Garcia-Quevedo, L., Vidal, F., Giorgetti, A., Veiga, A., Izpisua Belmonte, J.C. Complete meiosis from human induced pluripotent stem cells. (2011) Stem Cells. 29(8):1186-95. DOI: 10.1002/stem.672

Woods, N.B., Parker, A.S., Moraghebi, R., Lutz, M.K., Firth, A.L., Brennand, K.J., Berggren, W.T., Raya, A., Izpisúa Belmonte, J.C., Gage, F.H., Verma, I.M. Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines. (2011) Stem Cells. 29(7):1158-64. DOI: 10.1002/stem.657

Murphy, D.A., Diaz, B., Bromann, P.A., Tsai, J.H., Kawakami, Y., Maurer, J., Stewart, R.A., Izpisúa-Belmonte, J.C., Courtneidge, S.A. A Src-Tks5 pathway is required for neural crest cell migration during embryonic development. (2011) PLOS One. 6(7):e22499. DOI: 10.1371/journal.pone.0022499

Liu, G.H., Suzuki, K., Qu, J., Sancho-Martinez, I., Yi, F., Li, M., Kumar, S., Nivet, E., Kim, J., Soligalla, R.D., Dubova, I., Goebl, A., Plongthongkum, N., Fung, H.L., Zhang, K., Loring, J.F., Laurent, L.C., Izpisua Belmonte, J.C. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. (2011) Cell Stem Cell. 8(6):688-94. DOI: 10.1016/j.stem.2011.04.019

Adamo, A., Sesé, B., Boue, S., Castaño, J., Paramonov, I., Barrero, M.J., Izpisua Belmonte, J.C. LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells. (2011) Nature Cell Biology. 13(6):652-9. DOI: 10.1038/ncb2246

Robles, V., Martí, M., Izpisua Belmonte, J.C. Study of pluripotency markers in zebrafish embryos and transient embryonic stem cell cultures. (2011) Zebrafish. 8(2):57-63. DOI: 10.1089/zeb.2010.0684

Panopoulos, A.D., Ruiz, S., Yi, F., Herrerías, A., Batchelder, E.M., Izpisua Belmonte, J.C. Rapid and highly efficient generation of induced pluripotent stem cells from human umbilical vein endothelial cells. (2011) PLOS One. 6(5):e19743. DOI: 10.1371/journal.pone.0019743

Sancho-Martinez, I., Li, M., Izpisua Belmonte, J.C. Disease correction the iPSC way: advances in iPSC-based therapy. (2011) Clinical Pharmacology and Therapeutics. 89(5):746-9. DOI: 10.1038/clpt.2010.341

Barrero, M.J., Izpisua Belmonte, J.C. iPS cells forgive but do not forget. (2011) Nature Cell Biology. 13(5):523-5. DOI: 10.1038/ncb0511-523

Menchón, C., Edel, M.J., Izpisua Belmonte, J.C. The cell cycle inhibitor p27Kip¹ controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist. (2011) Cell Cycle. 10(9):1435-47. DOI: 10.4161/cc.10.9.15421

Panopoulos, A.D., Ruiz, S., Izpisua Belmonte, J.C. iPSCs: induced back to controversy. (2011) Cell Stem Cell. 8(4):347-8. DOI: 10.1016/j.stem.2011.03.003

Liu, G.H., Barkho, B.Z., Ruiz, S., Diep, D., Qu, J., Yang, S.L., Panopoulos, A.D., Suzuki, K., Kurian, L., Walsh, C., Thompson, J., Boue, S., Fung, H.L., Sancho-Martinez, I., Zhang, K., Yates, J., Izpisua Belmonte, J.C. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. (2011) Nature. 472(7342):221-5. DOI: 10.1038/nature09879

Edel, M.J., Menchon, C., Vaquero, J.M., Izpisua Belmonte, J.C. A protocol to assess cell cycle and apoptosis in human and mouse pluripotent cells. (2011) Cell Communication and Signaling. 9(1):8. DOI: 10.1186/1478-811X-9-8

González, F., Boué, S., Izpisúa Belmonte, J.C. Methods for making induced pluripotent stem cells: reprogramming à la carte. (2011) Nature Reviews. Genetics. 12(4):231-42. DOI: 10.1038/nrg2937

Montserrat, N., Garreta, E., González, F., Gutiérrez, J., Eguizábal, C., Ramos, V., Borrós, S., Izpisua Belmonte, J.C. Simple generation of human induced pluripotent stem cells using poly-beta-amino esters as the non-viral gene delivery system. (2011) Journal of Biological Chemistry. 286(14):12417-28. DOI: 10.1074/jbc.M110.168013

Montserrat, N., Bahima, E.G., Batlle, L., Häfner, S., Rodrigues, A.M., González, F., Izpisúa Belmonte, J.C. Generation of pig iPS cells: a model for cell therapy. (2011) J Cardiovasc Transl Res. 4(2):121-30. DOI: 10.1007/s12265-010-9233-3

Tiscornia, G., Monserrat, N., Izpisua Belmonte, J.C. Modelling long QT syndrome with iPS cells: be still, my beating heart ... (2011) Circulation research. 108(6):648-9. DOI: 10.1161/RES.0b013e318216f0db

Gore, A., Li, Z., Fung, H.L., Young, J.E., Agarwal, S., Antosiewicz-Bourget, J., Canto, I., Giorgetti, A., Israel, M.A., Kiskinis, E., Lee, J.H., Loh, Y.H., Manos, P.D., Montserrat, N., Panopoulos, A.D., Ruiz, S., Wilbert, M.L., Yu, J., Kirkness, E.F., Izpisua Belmonte, J.C., Rossi, D.J., Thomson, J.A., Eggan, K., Daley, G.Q., Goldstein, L.S., Zhang, K. Somatic coding mutations in human induced pluripotent stem cells. (2011) Nature. 471(7336):63-7. DOI: 10.1038/nature09805

Barrero, M.J., Izpisua Belmonte, J.C. Regenerating the epigenome. (2011) EMBO Reports. 12(3):208-15. DOI: 10.1038/embor.2011.10

Li, M., Sancho-Martinez, I., Izpisua Belmonte, J.C. Cell fate conversion by mRNA. (2011) Stem Cell Res Ther. 2(1):5. DOI: 10.1186/scrt46

Jopling, C., Boue, S., Izpisua Belmonte, J.C. Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. (2011) Nature Reviews. Molecular Cell Biology. 12(2):79-89. DOI: 10.1038/nrm3043

Ruiz, S., Panopoulos, A.D., Herrerías, A., Bissig, K.D., Lutz, M., Berggren, W.T., Verma, I.M., Izpisua Belmonte, J.C. A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. (2011) Current Biology. 21(1):45-52. DOI: 10.1016/j.cub.2010.11.049

Oishi, I., Kim, S., Yoshii, K., Esteban, C.R., Izpisua Belmonte, J.C. Cre-LoxP-regulated expression of monoclonal antibodies driven by an ovalbumin promoter in primary oviduct cells. (2011) BMC Biotechnol. 11:5. DOI: 10.1186/1472-6750-11-5

Laurent, L.C., Ulitsky, I., Slavin, I., Tran, H., Schork, A., Morey, R., Lynch, C., Harness, J.V., Lee, S., Barrero, M.J., Ku, S., Martynova, M., Semechkin, R., Galat, V., Gottesfeld, J., Izpisua Belmonte, J.C., Murry, C., Keirstead, H.S., Park, H.S., Schmidt, U., Laslett, A.L., Muller, F.J., Nievergelt, C.M., Shamir, R., Loring, J.F. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. (2011) Cell Stem Cell. 8(1):106-18. DOI: 10.1016/j.stem.2010.12.003

2010

Ruiz, S., Brennand, K., Panopoulos, A.D., Herrerías, A., Gage, F.H., Izpisua-Belmonte, J.C. High-efficient generation of induced pluripotent stem cells from human astrocytes. (2010) PLOS One. 5(12):e15526. DOI: 10.1371/journal.pone.0015526

Tiscornia, G., Izpisúa Belmonte, J.C. MicroRNAs in embryonic stem cell function and fate. (2010) Genes & Development. 24(24):2732-41. DOI: 10.1101/gad.1982910

Barrero, M.J., Boué, S., Izpisúa Belmonte, J.C. Epigenetic mechanisms that regulate cell identity. (2010) Cell Stem Cell. 7(5):565-70. DOI: 10.1016/j.stem.2010.10.009

Bayes-Genis, A., Soler-Botija, C., Farré, J., Sepúlveda, P., Raya, A., Roura, S., Prat-Vidal, C., Gálvez-Montón, C., Montero, J.A., Büscher, D., Izpisúa Belmonte, J.C. Human progenitor cells derived from cardiac adipose tissue ameliorate myocardial infarction in rodents. (2010) J. Mol. Cell. Cardiol. 49(5):771-80. DOI: 10.1016/j.yjmcc.2010.08.010

Masip, M., Veiga, A., Izpisúa Belmonte, J.C., Simón, C. Reprogramming with defined factors: from induced pluripotency to induced transdifferentiation. (2010) Mol. Hum. Reprod. 16(11):856-68. DOI: 10.1093/molehr/gaq059

Menendez, S., Camus, S., Izpisua Belmonte, J.C. p53: guardian of reprogramming. (2010) Cell Cycle. 9(19):3887-91. DOI: 10.4161/cc.9.19.13301

Boué, S., Paramonov, I., Barrero, M.J., Izpisúa Belmonte, J.C. Analysis of human and mouse reprogramming of somatic cells to induced pluripotent stem cells. What is in the plate? (2010) PLOS One. 5(9). DOI: 10.1371/journal.pone.0012664

Edel, M.J., Boué, S., Menchon, C., Sánchez-Danés, A., Izpisua Belmonte, J.C. Rem2 GTPase controls proliferation and apoptosis of neurons during embryo development. (2010) Cell Cycle. 9(17):3414-22. DOI: 10.4161/cc.9.17.12719

Santamaria, P., Rodriguez-Piza, I., Clemente-Casares, X., Yamanouchi, J., Mulero-Perez, L., Aasen, T., Raya, A., Izpisua Belmonte, J.C. Turning human epidermis into pancreatic endoderm. (2010) Review of Diabetic Studies. 7(2):158-67. DOI: 10.1900/RDS.2010.7.158

Montserrat, N., Jopling, C., Izpisúa Belmonte, J.C. Understanding the molecular basis for cardiomyocyte cell cycle regulation: new insights in cardiac regeneration after injury? (2010) Expert Review of Cardiovascular Therapy. 8(8):1043-5. DOI: 10.1586/erc.10.91

Isaacs, M.J., Kawakami, Y., Allendorph, G.P., Yoon, B.H., Izpisua Belmonte, J.C., Choe, S. Bone morphogenetic protein-2 and -6 heterodimer illustrates the nature of ligand-receptor assembly. (2010) Molecular Endocrinology. 24(7):1469-77. DOI: 10.1210/me.2009-0496

Edel, M.J., Izpisua Belmonte, J.C. The cell cycle and pluripotency: Is there a direct link? (2010) Cell Cycle. 9(14):2694-5. DOI: 10.4161/cc.9.14.12456

Valera, E., Isaacs, M.J., Kawakami, Y., Izpisúa Belmonte, J.C., Choe, S. BMP-2/6 heterodimer is more effective than BMP-2 or BMP-6 homodimers as inductor of differentiation of human embryonic stem cells. (2010) PLOS One. 5(6):e11167. DOI: 10.1371/journal.pone.0011167

Sleep, E., Boué, S., Jopling, C., Raya, M., Raya, A., Izpisua Belmonte, J.C. Transcriptomics approach to investigate zebrafish heart regeneration. (2010) Journal of Cardiovascular Medicine. 11(5):369-80. DOI: 10.2459/JCM.0b013e3283375900

Giorgetti, A., Montserrat, N., Rodriguez-Piza, I., Azqueta, C., Veiga, A., Izpisúa Belmonte, J.C. Generation of induced pluripotent stem cells from human cord blood cells with only two factors: Oct4 and Sox2. (2010) Nature Protocols. 5(4):811-20. DOI: 10.1038/nprot.2010.16

Raya, A., Rodríguez-Pizà, I., Navarro, S., Richaud-Patin, Y., Guenechea, G., Sánchez-Danés, A., Consiglio, A., Bueren, J., Izpisúa Belmonte, J.C. A protocol describing the genetic correction of somatic human cells and subsequent generation of iPS cells. (2010) Nature Protocols. 5(4):647-60. DOI: 10.1038/nprot.2010.9

Jopling, C., Sleep, E., Raya, M., Martí, M., Raya, A., Izpisúa Belmonte, J.C. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. (2010) Nature. 464(7288):606-9. DOI: 10.1038/nature08899

Edel, M.J., Menchon, C., Menendez, S., Consiglio, A., Raya, A., Izpisua Belmonte, J.C. Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1. (2010) Genes & Development. 24(6):561-73. DOI: 10.1101/gad.1876710

Sugii, S., Kida, Y., Kawamura, T., Suzuki, J., Vassena, R., Yin, Y.Q., Lutz, M.K., Berggren, W.T., Izpisúa Belmonte, J.C., Evans, R.M. Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(8):3558-63. DOI: 10.1073/pnas.0910172106

Aasen, T., Izpisúa Belmonte, J.C. Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells. (2010) Nature Protocols. 5(2):371-82. DOI: 10.1038/nprot.2009.241

Tramullas, M., Lantero, A., Díaz, A., Morchón, N., Merino, D., Villar, A., Buscher, D., Merino, R., Hurlé, J.M., Izpisúa-Belmonte, J.C., Hurlé, M.A. BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) reveals the involvement of the transforming growth factor-beta family in pain modulation. (2010) Journal of Neuroscience. 30(4):1502-11. DOI: 10.1523/JNEUROSCI.2584-09.2010

Christen, B., Robles, V., Raya, M., Paramonov, I., Izpisúa Belmonte, J.C. Regeneration and reprogramming compared. (2010) BMC Biology. 8:5. DOI: 10.1186/1741-7007-8-5

Rodríguez-Pizà, I., Richaud-Patin, Y., Vassena, R., González, F., Barrero, M.J., Veiga, A., Raya, A., Izpisúa Belmonte, J.C. Reprogramming of human fibroblasts to induced pluripotent stem cells under xeno-free conditions. (2010) Stem Cells. 28(1):36-44. DOI: 10.1002/stem.248

2009

Izpisúa Belmonte, J.C., Ellis, J., Hochedlinger, K., Yamanaka, S. Induced pluripotent stem cells and reprogramming: seeing the science through the hype. (2009) Nature Reviews. Genetics. 10(12):878-83. DOI: 10.1038/nrg2700

Stewart, S., Tsun, Z.Y., Izpisua Belmonte, J.C. A histone demethylase is necessary for regeneration in zebrafish. (2009) Proceedings of the National Academy of Sciences of the United States of America. 106(47):19889-94. DOI: 10.1073/pnas.0904132106

Kan, N.G., Junghans, D., Izpisua Belmonte, J.C. Compensatory growth mechanisms regulated by BMP and FGF signaling mediate liver regeneration in zebrafish after partial hepatectomy. (2009) FASEB Journal. 23(10):3516-25. DOI: 10.1096/fj.09-131730

Giorgetti, A., Montserrat, N., Aasen, T., Gonzalez, F., Rodríguez-Pizà, I., Vassena, R., Raya, A., Boué, S., Barrero, M.J., Corbella, B.A., Torrabadella, M., Veiga, A., Izpisua Belmonte, J.C. Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2. (2009) Cell Stem Cell. 5(4):353-7. DOI: 10.1016/j.stem.2009.09.008

Ibañes, M., Izpisúa Belmonte, J.C. Left-right axis determination. (2009) Wiley Interdisciplinary Reviews. Systems biology and Medicine. 1(2):210-9. DOI: 10.1002/wsbm.31

Kawamura, T., Suzuki, J., Wang, Y.V., Menendez, S., Morera, L.B., Raya, A., Wahl, G.M., Izpisúa Belmonte, J.C. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. (2009) Nature. 460(7259):1140-4. DOI: 10.1038/nature08311

Raya, A., Rodríguez-Pizà, I., Guenechea, G., Vassena, R., Navarro, S., Barrero, M.J., Consiglio, A., Castellà, M., Río, P., Sleep, E., González, F., Tiscornia, G., Garreta, E., Aasen, T., Veiga, A., Verma, I.M., Surrallés, J., Bueren, J., Izpisúa Belmonte, J.C. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. (2009) Nature. 460(7251):53-9. DOI: 10.1038/nature08129

Kelber, J.A., Panopoulos, A.D., Shani, G., Booker, E.C., Belmonte, J.C., Vale, W.W., Gray, P.C. Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways. (2009) Oncogene. 28(24):2324-36. DOI: 10.1038/onc.2009.97

Raya, A., Izpisúa Belmonte, J.C. Stem cell research in Spain: if only they were windmills... (2009) Cell Stem Cell. 4(6):483-6. DOI: 10.1016/j.stem.2009.05.016

Gonzalez, F., Barragan Monasterio, M., Tiscornia, G., Montserrat Pulido, N., Vassena, R., Batlle Morera, L., Rodriguez Piza, I., Izpisua Belmonte, J.C. Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector. (2009) Proceedings of the National Academy of Sciences of the United States of America. 106(22):8918-22. DOI: 10.1073/pnas.0901471106

Beck, C.W., Izpisúa Belmonte, J.C., Christen, B. Beyond early development: Xenopus as an emerging model for the study of regenerative mechanisms. (2009) Developmental Dynamics . 238(6):1226-48. DOI: 10.1002/dvdy.21890

Rojas-Muñoz, A., Rajadhyksha, S., Gilmour, D., van Bebber, F., Antos, C., Rodríguez Esteban, C., Nüsslein-Volhard, C., Izpisúa Belmonte, J.C. ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration. (2009) Developmental Biology. 327(1):177-90. DOI: 10.1016/j.ydbio.2008.12.012

Jopling, C., Izpisua Belmonte, J.C. Cilia--where two Wnts collide. (2009) Zebrafish. 6(1):15-9. DOI: 10.1089/zeb.2008.0560

Kawakami, Y., Uchiyama, Y., Rodriguez Esteban, C., Inenaga, T., Koyano-Nakagawa, N., Kawakami, H., Marti, M., Kmita, M., Monaghan-Nichols, P., Nishinakamura, R., Izpisua Belmonte, J.C. Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities. (2009) Development. 136(4):585-94. DOI: 10.1242/dev.027748

Fink, M., Callol-Massot, C., Chu, A., Ruiz-Lozano, P., Izpisua Belmonte, J.C., Giles, W., Bodmer, R., Ocorr, K. A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. (2009) BioTechniques. 46(2):101-13. DOI: 10.2144/000113078

2008

Stubbs, J.L., Oishi, I., Izpisúa Belmonte, J.C., Kintner, C. The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos. (2008) Nature Genetics. 40(12):1454-60. DOI: 10.1038/ng.267

Aasen, T., Raya, A., Barrero, M.J., Garreta, E., Consiglio, A., Gonzalez, F., Vassena, R., Bilić, J., Pekarik, V., Tiscornia, G., Edel, M., Boué, S., Izpisúa Belmonte, J.C. Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. (2008) Nature Biotechnology. 26(11):1276-84. DOI: 10.1038/nbt.1503

Pekarik, V., Izpisua Belmonte, J.C. NFIX--one gene, two knockouts, multiple effects. (2008) Journal of Biology. 7(8):29. DOI: 10.1186/jbiol94

Kang, J.S., Kawakami, Y., Bekku, Y., Ninomiya, Y., Izpisúa Belmonte, J.C., Oohashi, T. Molecular cloning and developmental expression of a hyaluronan and proteoglycan link protein gene, crtl1/hapln1, in zebrafish. (2008) Zool. Sci. 25(9):912-8. DOI: 10.2108/zsj.25.912

Rodríguez-León, J., Rodríguez Esteban, C., Martí, M., Santiago-Josefat, B., Dubova, I., Rubiralta, X., Izpisúa Belmonte, J.C. Pitx2 regulates gonad morphogenesis. (2008) Proceedings of the National Academy of Sciences of the United States of America. 105(32):11242-7. DOI: 10.1073/pnas.0804904105

Tugores, A., Izpisua Belmonte, J.C. Differential display of eukaryotic mRNA. (2008) Methods in Molecular Biology. 461:589-604. DOI: 10.1007/978-1-60327-483-8_40

Blumberg, B., Izpisúa Belmonte, J.C. Subtractive hybridization and construction of cDNA libraries. (2008) Methods in Molecular Biology. 461:569-87. DOI: 10.1007/978-1-60327-483-8_39

Kurpios, N.A., Ibañes, M., Davis, N.M., Lui, W., Katz, T., Martin, J.F., Izpisúa Belmonte, J.C., Tabin, C.J. The direction of gut looping is established by changes in the extracellular matrix and in cell:cell adhesion. (2008) Proceedings of the National Academy of Sciences of the United States of America. 105(25):8499-506. DOI: 10.1073/pnas.0803578105

Raya, A., Izpisúa Belmonte, J.C. Insights into the establishment of left-right asymmetries in vertebrates. (2008) Birth Defects Res. C Embryo Today. 84(2):81-94. DOI: 10.1002/bdrc.20122

Suzuki, A., Sekiya, S., Büscher, D., Izpisúa Belmonte, J.C., Taniguchi, H. Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression. (2008) Development. 135(9):1589-95. DOI: 10.1242/dev.016634

Moreno, T.A., Jappelli, R., Izpisúa Belmonte, J.C., Kintner, C. Retinoic acid regulation of the Mesp-Ripply feedback loop during vertebrate segmental patterning. (2008) Developmental Biology. 315(2):317-30. DOI: 10.1016/j.ydbio.2007.12.038

Ibañes, M., Izpisúa Belmonte, J.C. Theoretical and experimental approaches to understand morphogen gradients. (2008) Molecular Systems Biology. 4:176. DOI: 10.1038/msb.2008.14

Garcia-Gonzalo, F.R., Izpisúa Belmonte, J.C. Albumin-associated lipids regulate human embryonic stem cell self-renewal. (2008) PLOS One. 3(1):e1384. DOI: 10.1371/journal.pone.0001384

2007

Stewart, S., Rojas-Muñoz, A., Izpisúa Belmonte, J.C. Bioelectricity and epimorphic regeneration. (2007) BioEssays. 29(11):1133-7. DOI: 10.1002/bies.20656

Allendorph, G.P., Isaacs, M.J., Kawakami, Y., Izpisua Belmonte, J.C., Choe, S. BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors. (2007) Biochemistry. 46(43):12238-47. DOI: 10.1021/bi700907k

Sahara, S., Kawakami, Y., Izpisua Belmonte, J.C., O'Leary, D.D. Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning. (2007) Neural Dev. 2:10. DOI: 10.1186/1749-8104-2-10

Ribeiro, I., Kawakami, Y., Büscher, D., Raya, A., Rodríguez-León, J., Morita, M., Rodríguez Esteban, C., Izpisúa Belmonte, J.C. Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart remodeling. (2007) PLOS One. 2(4):e398. DOI: 10.1371/journal.pone.0000398

Matsui, T., Raya, A., Callol-Massot, C., Kawakami, Y., Oishi, I., Rodriguez-Esteban, C., Izpisúa Belmonte, J.C. miles-apart-Mediated regulation of cell-fibronectin interaction and myocardial migration in zebrafish. (2007) Nature Clinical Practice. Cardiovascular Medicine. 4 Suppl 1:S77-82. DOI: 10.1038/ncpcardio0764

Zuzarte-Luis, V., Montero, J.A., Kawakami, Y., Izpisua-Belmonte, J.C., Hurle, J.M. Lysosomal cathepsins in embryonic programmed cell death. (2007) Developmental Biology. 301(1):205-17. DOI: 10.1016/j.ydbio.2006.08.008

2006

Kawakami, Y., Rodriguez Esteban, C., Raya, M., Kawakami, H., Martí, M., Dubova, I., Izpisúa Belmonte, J.C. Wnt/beta-catenin signaling regulates vertebrate limb regeneration. (2006) Genes & Development. 20(23):3232-7. DOI: 10.1101/gad.1475106

Kawakami, Y., Rodriguez-León, J., Izpisúa Belmonte, J.C. The role of TGFbetas and Sox9 during limb chondrogenesis. (2006) Current Opinion in Cell Biology. 18(6):723-9. DOI: 10.1016/j.ceb.2006.10.007

Oishi, I., Kawakami, Y., Raya, A., Callol-Massot, C., Izpisúa Belmonte, J.C. Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya. (2006) Nature Genetics. 38(11):1316-22. DOI: 10.1038/ng1892

Ibañes, M., Kawakami, Y., Rasskin-Gutman, D., Izpisúa Belmonte, J.C. Cell lineage transport: a mechanism for molecular gradient formation. (2006) Mol. Syst. Biol. 2:57. DOI: 10.1038/msb4100098

Suzuki, A., Raya, A., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F.H., Rodríguez-Esteban, C., Izpisúa Belmonte, J.C. Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(27):10294-9. DOI: 10.1073/pnas.0506945103

Weninger, W.J., Geyer, S.H., Mohun, T.J., Rasskin-Gutman, D., Matsui, T., Ribeiro, I., Costa, L.d.a.F., Izpisúa-Belmonte, J.C., Müller, G.B. High-resolution episcopic microscopy: a rapid technique for high detailed 3D analysis of gene activity in the context of tissue architecture and morphology. (2006) Anat. Embryol. 211(3):213-21. DOI: 10.1007/s00429-005-0073-x

Raya, A., Izpisúa Belmonte, J.C. Left-right asymmetry in the vertebrate embryo: from early information to higher-level integration. (2006) Nature Reviews. Genetics. 7(4):283-93. DOI: 10.1038/nrg1830

Suzuki, A., Raya, A., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F.H., Rodríguez-Esteban, C., Izpisúa Belmonte, J.C. Maintenance of embryonic stem cell pluripotency by Nanog-mediated reversal of mesoderm specification. (2006) Nature Clinical Practice. Cardiovascular Medicine. 3 Suppl 1:S114-22. DOI: 10.1038/ncpcardio0442

Luesch, H., Chanda, S.K., Raya, R.M., DeJesus, P.D., Orth, A.P., Walker, J.R., Izpisúa Belmonte, J.C., Schultz, P.G. A functional genomics approach to the mode of action of apratoxin A. (2006) Nature Chemical Biology. 2(3):158-67. DOI: 10.1038/nchembio769

2005

Merki, E., Zamora, M., Raya, A., Kawakami, Y., Wang, J., Zhang, X., Burch, J., Kubalak, S.W., Kaliman, P., Izpisua Belmonte, J.C., Chien, K.R., Ruiz-Lozano, P. Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. (2005) Proceedings of the National Academy of Sciences of the United States of America. 102(51):18455-60. DOI: 10.1073/pnas.0504343102

Buceta, J., Ibañes, M., Rasskin-Gutman, D., Okada, Y., Hirokawa, N., Izpisúa-Belmonte, J.C. Nodal cilia dynamics and the specification of the left/right axis in early vertebrate embryo development. (2005) Biophysical Journal. 89(4):2199-209. DOI: 10.1529/biophysj.105.063743

Correa, R.G., Matsui, T., Tergaonkar, V., Rodriguez-Esteban, C., Izpisua-Belmonte, J.C., Verma, I.M. Zebrafish IkappaB kinase 1 negatively regulates NF-kappaB activity. (2005) Current Biology. 15(14):1291-5. DOI: 10.1016/j.cub.2005.06.023

Kawakami, Y., Raya, A., Raya, R.M., Rodríguez-Esteban, C., Izpisúa Belmonte, J.C. Retinoic acid signalling links left-right asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. (2005) Nature. 435(7039):165-71. DOI: 10.1038/nature03512

Okada, Y., Takeda, S., Tanaka, Y., Izpisúa Belmonte, J.C., Hirokawa, N. Mechanism of nodal flow: a conserved symmetry breaking event in left-right axis determination. (2005) Cell. 121(4):633-44. DOI: 10.1016/j.cell.2005.04.008

Francisco-Morcillo, J., Sánchez-Calderón, H., Kawakami, Y., Izpisúa Belmonte, J.C., Hidalgo-Sánchez, M., Martín-Partido, G. Expression of Fgf19 in the developing chick eye. (2005) Brain Res. Dev. Brain Res. 156(1):104-9. DOI: 10.1016/j.devbrainres.2004.12.011

Kawakami, Y., Tsuda, M., Takahashi, S., Taniguchi, N., Esteban, C.R., Zemmyo, M., Furumatsu, T., Lotz, M., Izpisúa Belmonte, J.C., Asahara, H. Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9. (2005) Proceedings of the National Academy of Sciences of the United States of America. 102(7):2414-9. DOI: 10.1073/pnas.0407510102

Matsui, T., Raya, A., Kawakami, Y., Callol-Massot, C., Capdevila, J., Rodríguez-Esteban, C., Izpisúa Belmonte, J.C. Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. (2005) Genes & Development. 19(1):164-75. DOI: 10.1101/gad.1253605

2004

Raya, A., Izpisúa Belmonte, J.C. Sequential transfer of left-right information during vertebrate embryo development. (2004) Current Opinion in Genetics & Development. 14(5):575-81. DOI: 10.1016/j.gde.2004.07.011

Kawakami, Y., Esteban, C.R., Matsui, T., Rodríguez-León, J., Kato, S., Izpisúa Belmonte, J.C. Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos. (2004) Development. 131(19):4763-74. DOI: 10.1242/dev.01331

Raya, A., Izpisua Belmonte, J.C. Unveiling the establishment of left-right asymmetry in the chick embryo. (2004) Mech. Dev. 121(9):1043-54. DOI: 10.1016/j.mod.2004.05.005

Correa, R.G., Tergaonkar, V., Ng, J.K., Dubova, I., Izpisua-Belmonte, J.C., Verma, I.M. Characterization of NF-kappa B/I kappa B proteins in zebra fish and their involvement in notochord development. (2004) Molecular and Cellular Biology. 24(12):5257-68. DOI: 10.1128/MCB.24.12.5257-5268.2004

Raya, A., Consiglio, A., Kawakami, Y., Rodriguez-Esteban, C., Izpisúa-Belmonte, J.C. The zebrafish as a model of heart regeneration. (2004) Cloning and Stem Cells. 6(4):345-51. DOI: 10.1089/clo.2004.6.345

Rasskin-Gutman, D., Izpisúa-Belmonte, J.C. Theoretical morphology of developmental asymmetries. (2004) Bioessays. 26(4):405-12. DOI: 10.1002/bies.10410

Saez, E., Rosenfeld, J., Livolsi, A., Olson, P., Lombardo, E., Nelson, M., Banayo, E., Cardiff, R.D., Izpisua-Belmonte, J.C., Evans, R.M. PPAR gamma signaling exacerbates mammary gland tumor development. (2004) Genes & Development. 18(5):528-40. DOI: 10.1101/gad.1167804

Kang, J.S., Oohashi, T., Kawakami, Y., Bekku, Y., Izpisúa Belmonte, J.C., Ninomiya, Y. Characterization of dermacan, a novel zebrafish lectican gene, expressed in dermal bones. (2004) Mech. Dev. 121(3):301-12. DOI: 10.1016/j.mod.2004.01.007

Huang, Q., Raya, A., DeJesus, P., Chao, S.H., Quon, K.C., Caldwell, J.S., Chanda, S.K., Izpisua-Belmonte, J.C., Schultz, P.G. Identification of p53 regulators by genome-wide functional analysis. (2004) Proceedings of the National Academy of Sciences of the United States of America. 101(10):3456-61. DOI: 10.1073/pnas.0308562100

Raya, A., Kawakami, Y., Rodríguez-Esteban, C., Ibañes, M., Rasskin-Gutman, D., Rodríguez-León, J., Büscher, D., Feijó, J.A., Izpisúa Belmonte, J.C. Notch activity acts as a sensor for extracellular calcium during vertebrate left-right determination. (2004) Nature. 427(6970):121-8. DOI: 10.1038/nature02190

Timmerman, L.A., Grego-Bessa, J., Raya, A., Bertrán, E., Pérez-Pomares, J.M., Díez, J., Aranda, S., Palomo, S., McCormick, F., Izpisúa-Belmonte, J.C., de la Pompa, J.L. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. (2004) Genes & Development. 18(1):99-115. DOI: 10.1101/gad.276304

2003

Raya, A., Koth, C.M., Büscher, D., Kawakami, Y., Itoh, T., Raya, R.M., Sternik, G., Tsai, H.J., Rodríguez-Esteban, C., Izpisúa-Belmonte, J.C. Activation of Notch signaling pathway precedes heart regeneration in zebrafish. (2003) Proceedings of the National Academy of Sciences of the United States of America. 100 Suppl :11889-95. DOI: 10.1073/pnas.1834204100

Groppe, J., Greenwald, J., Wiater, E., Rodriguez-Leon, J., Economides, A.N., Kwiatkowski, W., Baban, K., Affolter, M., Vale, W.W., Izpisua Belmonte, J.C., Choe, S. Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein. (2003) Journal of Bone and Joint Surgery. 85-A Suppl:52-8.

Kawakami, Y., Rodríguez-León, J., Koth, C.M., Büscher, D., Itoh, T., Raya, A., Ng, J.K., Esteban, C.R., Takahashi, S., Henrique, D., Schwarz, M.F., Asahara, H., Izpisúa Belmonte, J.C. MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb. (2003) Nature Cell Biology. 5(6):513-9. DOI: 10.1038/ncb989

Raya, A., Kawakami, Y., Rodriguez-Esteban, C., Buscher, D., Koth, C.M., Itoh, T., Morita, M., Raya, R.M., Dubova, I., Bessa, J.G., de la Pompa, J.L., Izpisua Belmonte, J.C. Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. (2003) Genes & Development. 17(10):1213-8. DOI: 10.1101/gad.1084403

2002

Groppe, J., Greenwald, J., Wiater, E., Rodriguez-Leon, J., Economides, A.N., Kwiatkowski, W., Affolter, M., Vale, W.W., Izpisua Belmonte, J.C., Choe, S. Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. (2002) Nature. 420(6916):636-42. DOI: 10.1038/nature01245

Ng, J.K., Kawakami, Y., Büscher, D., Raya, A., Itoh, T., Koth, C.M., Rodríguez Esteban, C., Rodríguez-León, J., Garrity, D.M., Fishman, M.C., Izpisúa Belmonte, J.C. The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10. (2002) Development. 129(22):5161-70.

Trelles, R.D., León, J.R., Kawakami, Y., Simoes, S., Izpisúa Belmonte, J.C. Expression of the chick vascular endothelial growth factor D gene during limb development. (2002) Mech. Dev. 116(1-2):239-42.

2001

Mukhopadhyay, M., Shtrom, S., Rodriguez-Esteban, C., Chen, L., Tsukui, T., Gomer, L., Dorward, D.W., Glinka, A., Grinberg, A., Huang, S.P., Niehrs, C., Izpisúa Belmonte, J.C., Westphal, H. Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. (2001) Developmental Cell. 1(3):423-34.

Rodríguez-Esteban, C., Capdevila, J., Kawakami, Y., Izpisúa Belmonte, J.C. Wnt signaling and PKA control Nodal expression and left-right determination in the chick embryo. (2001) Development. 128(16):3189-95.

Capdevila, J., Izpisúa Belmonte, J.C. Patterning mechanisms controlling vertebrate limb development. (2001) Annual Review of Cell and Developmental Biology. 17:87-132. DOI: 10.1146/annurev.cellbio.17.1.87

Sharma, K., Izpisúa Belmonte, J.C. Development of the limb neuromuscular system. (2001) Current Opinion in Cell Biology. 13(2):204-10.

Kawakami, Y., Capdevila, J., Büscher, D., Itoh, T., Rodríguez Esteban, C., Izpisúa Belmonte, J.C. WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo. (2001) Cell. 104(6):891-900.

2000

Capdevila, J., Izpisúa Belmonte, J.C. Perspectives on the evolutionary origin of tetrapod limbs. (2000) J. Exp. Zool. 288(4):287-303. DOI: 10.1002/1097-010X(20001215)288:4<287::AID-JEZ2>3.0

Tavares, A.T., Tsukui, T., Izpisúa Belmonte, J.C. Evidence that members of the Cut/Cux/CDP family may be involved in AER positioning and polarizing activity during chick limb development. (2000) Development. 127(23):5133-44.

Liang, J.O., Etheridge, A., Hantsoo, L., Rubinstein, A.L., Nowak, S.J., Izpisúa Belmonte, J.C., Halpern, M.E. Asymmetric nodal signaling in the zebrafish diencephalon positions the pineal organ. (2000) Development. 127(23):5101-12.

Ruiz-Lozano, P., Ryan, A.K., Izpisua-Belmonte, J.C. Left-right determination. (2000) Trends Cardiovasc. Med. 10(6):258-62.

Ryan, A.K., Izpisúa Belmonte, J.C. Establishing a left-right axis in the embryo. (2000) IUBMB Life. 50(1):1-11. DOI: 10.1080/15216540050176520

Capdevila, J., Vogan, K.J., Tabin, C.J., Izpisúa Belmonte, J.C. Mechanisms of left-right determination in vertebrates. (2000) Cell. 101(1):9-21. DOI: 10.1016/S0092-8674(00)80619-4

Capdevila, I., Izpisúa Belmonte, J.C. Knowing left from right: the molecular basis of laterality defects. (2000) Molecular Medicine Today. 6(3):112-8.

Yokoyama, H., Yonei-Tamura, S., Endo, T., Izpisúa Belmonte, J.C., Tamura, K., Ide, H. Mesenchyme with fgf-10 expression is responsible for regenerative capacity in Xenopus limb buds. (2000) Developmental Biology. 219(1):18-29. DOI: 10.1006/dbio.1999.9587

1999

Tamura, K., Yonei-Tamura, S., Izpisúa Belmonte, J.C. Molecular basis of left-right asymmetry. (1999) Development, Growth & Differentiation. 41(6):645-56.

Capdevila, J., Tsukui, T., Rodríquez Esteban, C., Zappavigna, V., Izpisúa Belmonte, J.C. Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. (1999) Molecular Cell. 4(5):839-49.

Tsukui, T., Capdevila, J., Tamura, K., Ruiz-Lozano, P., Rodriguez-Esteban, C., Yonei-Tamura, S., Magallón, J., Chandraratna, R.A., Chien, K., Blumberg, B., Evans, R.M., Belmonte, J.C. Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. (1999) Proceedings of the National Academy of Sciences of the United States of America. 96(20):11376-81.

Rodríguez Esteban, C., Capdevila, J., Economides, A.N., Pascual, J., Ortiz, A., Izpisúa Belmonte, J.C. The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry. (1999) Nature. 401(6750):243-51. DOI: 10.1038/45738

Tamura, K., Yonei-Tamura, S., Izpisúa Belmonte, J.C. Differential expression of Tbx4 and Tbx5 in Zebrafish fin buds. (1999) Mech. Dev. 87(1-2):181-4.

Lin, C.R., Kioussi, C., O'Connell, S., Briata, P., Szeto, D., Liu, F., Izpisúa-Belmonte, J.C., Rosenfeld, M.G. Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. (1999) Nature. 401(6750):279-82. DOI: 10.1038/45803

Bach, I., Rodriguez-Esteban, C., Carrière, C., Bhushan, A., Krones, A., Rose, D.W., Glass, C.K., Andersen, B., Izpisúa Belmonte, J.C., Rosenfeld, M.G. RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. (1999) Nature Genetics. 22(4):394-9. DOI: 10.1038/11970

Huang, R., Zhi, Q., Izpisua-Belmonte, J.C., Christ, B., Patel, K. Origin and development of the avian tongue muscles. (1999) Anatomy and Embryology. 200(2):137-52.

Torok, M.A., Gardiner, D.M., Izpisúa-Belmonte, J.C., Bryant, S.V. Sonic hedgehog (shh) expression in developing and regenerating axolotl limbs. (1999) Journal of Experimental Zoology. 284(2):197-206.

García-Domingo, D., Leonardo, E., Grandien, A., Martínez, P., Albar, J.P., Izpisúa-Belmonte, J.C., Martínez-A, C. DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development. (1999) Proceedings of the National Academy of Sciences of the United States of America. 96(14):7992-7.

Izpisúa Belmonte, J.C. How the body tells left from right. (1999) Sci. Am. 280(6):46-51.

Li, Q., Lu, Q., Hwang, J.Y., Büscher, D., Lee, K.F., Izpisua-Belmonte, J.C., Verma, I.M. IKK1-deficient mice exhibit abnormal development of skin and skeleton. (1999) Genes & Development. 13(10):1322-8.

Merino, R., Macias, D., Gañan, Y., Rodriguez-Leon, J., Economides, A.N., Rodriguez-Esteban, C., Izpisua-Belmonte, J.C., Hurle, J.M. Control of digit formation by activin signalling. (1999) Development. 126(10):2161-70.

Rodriguez-Esteban, C., Tsukui, T., Yonei, S., Magallon, J., Tamura, K., Izpisua Belmonte, J.C. The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity. (1999) Nature. 398(6730):814-8. DOI: 10.1038/19769

Büscher, D., Izpisúa Belmonte, J.C. Muscle development during vertebrate limb outgrowth. (1999) Cell and Tissue Research. 296(1):131-9.

Ng, J.K., Tamura, K., Büscher, D., Izpisúa-Belmonte, J.C. Molecular and cellular basis of pattern formation during vertebrate limb development. (1999) Current Topics in Developmental Biology. 41:37-66.

Rincón-Limas, D.E., Lu, C.H., Canal, I., Calleja, M., Rodríguez-Esteban, C., Izpisúa-Belmonte, J.C., Botas, J. Conservation of the expression and function of apterous orthologs in Drosophila and mammals. (1999) Proceedings of the National Academy of Sciences of the United States of America. 96(5):2165-70.

Yonei-Tamura, S., Tamura, K., Tsukui, T., Izpisúa Belmonte, J.C. Spatially and temporally-restricted expression of two T-box genes during zebrafish embryogenesis. (1999) Mechanisms of Development. 80(2):219-21.

Szeto, D.P., Rodriguez-Esteban, C., Ryan, A.K., O'Connell, S.M., Liu, F., Kioussi, C., Gleiberman, A.S., Izpisúa-Belmonte, J.C., Rosenfeld, M.G. Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development. (1999) Genes & Development. 13(4):484-94.

Blumberg, B., Izpisúa Belmonte, J.C. Subtractive hybridization and construction of cDNA libraries. (1999) Methods in Molecular Biology. 97:555-74. DOI: 10.1385/1-59259-270-8:555

1998

Yamada, G., Nakamura, S., Fukuzaki, K., Izumi, H., Horai, N., Nagata, R., Minami, T., Tohno, Y., Suzuki, K., Haraguchi, R., Miyado, K., Toyoda, T., Izpisua-Belmonte, J.C., Maruyama, I., Kitajima, I. Dysregulation of trace element composition in ovariectomized cynomolgus monkey bones. (1998) Cellular and Molecular Biology. 44(8):1205-13.

Takahashi, M., Tamura, K., Büscher, D., Masuya, H., Yonei-Tamura, S., Matsumoto, K., Naitoh-Matsuo, M., Takeuchi, J., Ogura, K., Shiroishi, T., Ogura, T., Izpisúa Belmonte, J.C. The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development. (1998) Development. 125(22):4417-25.

Rodriguez-Esteban, C., Schwabe, J.W., Peña, J.D., Rincon-Limas, D.E., Magallón, J., Botas, J., Izpisúa Belmonte, J.C. Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth. (1998) Development. 125(20):3925-34.

Ryan, A.K., Blumberg, B., Rodriguez-Esteban, C., Yonei-Tamura, S., Tamura, K., Tsukui, T., de la Peña, J., Sabbagh, W., Greenwald, J., Choe, S., Norris, D.P., Robertson, E.J., Evans, R.M., Rosenfeld, M.G., Izpisúa Belmonte, J.C. Pitx2 determines left-right asymmetry of internal organs in vertebrates. (1998) Nature. 394(6693):545-51. DOI: 10.1038/29004

Schwabe, J.W., Rodriguez-Esteban, C., Izpisúa Belmonte, J.C. Limbs are moving: where are they going? (1998) Trends in Genetics. 14(6):229-35.

Kengaku, M., Capdevila, J., Rodriguez-Esteban, C., De La Peña, J., Johnson, R.L., Izpisúa Belmonte, J.C., Tabin, C.J. Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. (1998) Science. 280(5367):1274-7. DOI: 10.1126/science.280.5367.1274

Isaac, A., Rodriguez-Esteban, C., Ryan, A., Altabef, M., Tsukui, T., Patel, K., Tickle, C., Izpisúa-Belmonte, J.C. Tbx genes and limb identity in chick embryo development. (1998) Development. 125(10):1867-75.

Kanegae, Y., Tavares, A.T., Izpisúa Belmonte, J.C., Verma, I.M. Role of Rel/NF-kappaB transcription factors during the outgrowth of the vertebrate limb. (1998) Nature. 392(6676):611-4. DOI: 10.1038/33429

1997

Heanue, T.A., Johnson, R.L., Izpisua-Belmonte, J.C., Stern, C.D., De Robertis, E.M., Tabin, C.J. Goosecoid misexpression alters the morphology and Hox gene expression of the developing chick limb bud. (1997) Mech. Dev. 69(1-2):31-7.

Pfeffer, P.L., De Robertis, E.M., Izpisua-Belmonte, J.C. Crescent, a novel chick gene encoding a Frizzled-like cysteine-rich domain, is expressed in anterior regions during early embryogenesis. (1997) Int. J. Dev. Biol. 41(3):449-58.

Schwabe, J.W., Rodriguez-Esteban, C., De La Peña, J., Tavares, A.T., Ng, J.K., Banayo, E.M., Foys, B., Eshelman, B., Magallon, J., Tam, R., Izpisúa-Belmonte, J.C. Outgrowth and patterning of the vertebrate limb. (1997) Cold Spring Harbor Symposia on Quantitative Biology. 62:431-5.

Lemaire, L., Roeser, T., Izpisúa-Belmonte, J.C., Kessel, M. Segregating expression domains of two goosecoid genes during the transition from gastrulation to neurulation in chick embryos. (1997) Development. 124(8):1443-52.

Rodriguez-Esteban, C., Schwabe, J.W., De La Peña, J., Foys, B., Eshelman, B., Izpisúa Belmonte, J.C. Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb. (1997) Nature. 386(6623):360-6. DOI: 10.1038/386360a0

1996

Ros, M.A., López-Martínez, A., Simandl, B.K., Rodriguez, C., Izpisúa Belmonte, J.C., Dahn, R., Fallon, J.F. The limb field mesoderm determines initial limb bud anteroposterior asymmetry and budding independent of sonic hedgehog or apical ectodermal gene expressions. (1996) Development. 122(8):2319-30.

Vogel, A., Rodriguez, C., Izpisúa-Belmonte, J.C. Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb. (1996) Development. 122(6):1737-50.

Ogura, T., Alvarez, I.S., Vogel, A., Rodríguez, C., Evans, R.M., Izpisúa Belmonte, J.C. Evidence that Shh cooperates with a retinoic acid inducible co-factor to establish ZPA-like activity. (1996) Development. 122(2):537-42.

Rodriguez, C., Kos, R., Macias, D., Abbott, U.K., Izpisúa Belmonte, J.C. Shh, HoxD, Bmp-2, and Fgf-4 gene expression during development of the polydactylous talpid2, diplopodia1, and diplopodia4 mutant chick limb buds. (1996) Dev. Genet. 19(1):26-32. DOI: 10.1002/(SICI)1520-6408(1996)19:1<26::AID-DVG3>3.0

van der Hoeven, F., Sordino, P., Fraudeau, N., Izpisúa-Belmonte, J.C., Duboule, D. Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex. (1996) Mech. Dev. 54(1):9-21.

1995

Vogel, A., Rodriguez, C., Warnken, W., Izpisúa Belmonte, J.C. Dorsal cell fate specified by chick Lmx1 during vertebrate limb development. (1995) Nature. 378(6558):716-20. DOI: 10.1038/378716a0

Sucov, H.M., Izpisúa-Belmonte, J.C., Gañan, Y., Evans, R.M. Mouse embryos lacking RXR alpha are resistant to retinoic-acid-induced limb defects. (1995) Development. 121(12):3997-4003.

Hardy, A., Richardson, M.K., Francis-West, P.H., Rodriguez, C., Izpisúa-Belmonte, J.C., Duprez, D., Wolpert, L. Gene expression, polarising activity and skeletal patterning in reaggregated hind limb mesenchyme. (1995) Development. 121(12):4329-37.

Francis-West, P.H., Robertson, K.E., Ede, D.A., Rodriguez, C., Izpisúa-Belmonte, J.C., Houston, B., Burt, D.W., Gribbin, C., Brickell, P.M., Tickle, C. Expression of genes encoding bone morphogenetic proteins and sonic hedgehog in talpid (ta3) limb buds: their relationships in the signalling cascade involved in limb patterning. (1995) Developmental Dynamics . 203(2):187-97. DOI: 10.1002/aja.1002030207

Cohn, M.J., Izpisúa-Belmonte, J.C., Abud, H., Heath, J.K., Tickle, C. Fibroblast growth factors induce additional limb development from the flank of chick embryos. (1995) Cell. 80(5):739-46.

1994

Fjose, A., Izpisúa-Belmonte, J.C., Fromental-Ramain, C., Duboule, D. Expression of the zebrafish gene hlx-1 in the prechordal plate and during CNS development. (1994) Development. 120(1):71-81.

1993

Izpisúa-Belmonte, J.C., De Robertis, E.M., Storey, K.G., Stern, C.D. The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm. (1993) Cell. 74(4):645-59.

Dollé, P., Izpisúa-Belmonte, J.C., Brown, J., Tickle, C., Duboule, D. Hox genes and the morphogenesis of the vertebrate limb. (1993) Prog. Clin. Biol. Res. 383A:11-20.

1992

Morgan, B.A., Izpisúa-Belmonte, J.C., Duboule, D., Tabin, C.J. Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations. (1992) Nature. 358(6383):236-9. DOI: 10.1038/358236a0

Izpisúa-Belmonte, J.C., Duboule, D. Homeobox genes and pattern formation in the vertebrate limb. (1992) Developmental Biology. 152(1):26-36.

Izpisúa-Belmonte, J.C., Brown, J.M., Crawley, A., Duboule, D., Tickle, C. Hox-4 gene expression in mouse/chicken heterospecific grafts of signalling regions to limb buds reveals similarities in patterning mechanisms. (1992) Development. 115(2):553-60.

Izpisúa-Belmonte, J.C., Ede, D.A., Tickle, C., Duboule, D. The mis-expression of posterior Hox-4 genes in talpid (ta3) mutant wings correlates with the absence of anteroposterior polarity. (1992) Development. 114(4):959-63.

Renucci, A., Zappavigna, V., Zàkàny, J., Izpisúa-Belmonte, J.C., Bürki, K., Duboule, D. Comparison of mouse and human HOX-4 complexes defines conserved sequences involved in the regulation of Hox-4.4. (1992) EMBO Journal. 11(4):1459-68.

Izpisúa-Belmonte, J.C., Brown, J.M., Duboule, D., Tickle, C. Expression of Hox-4 genes in the chick wing links pattern formation to the epithelial-mesenchymal interactions that mediate growth. (1992) EMBO Journal. 11(4):1451-7.

Bastian, H., Gruss, P., Duboule, D., Izpisúa-Belmonte, J.C. The murine even-skipped-like gene Evx-2 is closely linked to the Hox-4 complex, but is transcribed in the opposite direction. (1992) Mamm. Genome. 3(4):241-3.

1991

Zappavigna, V., Renucci, A., Izpisúa-Belmonte, J.C., Urier, G., Peschle, C., Duboule, D. HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. (1991) EMBO Journal. 10(13):4177-87.

Dollé, P., Izpisúa-Belmonte, J.C., Boncinelli, E., Duboule, D. The Hox-4.8 gene is localized at the 5' extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development. (1991) Mech. Dev. 36(1-2):3-13.

Dollé, P., Izpisúa-Belmonte, J.C., Brown, J.M., Tickle, C., Duboule, D. HOX-4 genes and the morphogenesis of mammalian genitalia. (1991) Genes & Development. 5(10):1767-7.

Izpisúa-Belmonte, J.C., Falkenstein, H., Dollé, P., Renucci, A., Duboule, D. Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body. (1991) EMBO Journal. 10(8):2279-89.

Izpisúa-Belmonte, J.C., Tickle, C., Dollé, P., Wolpert, L., Duboule, D. Expression of the homeobox Hox-4 genes and the specification of position in chick wing development. (1991) Nature. 350(6319):585-9. DOI: 10.1038/350585a0

1990

Izpisùa-Belmonte, J.C., Dollé, P., Renucci, A., Zappavigna, V., Falkenstein, H., Duboule, D. Primary structure and embryonic expression pattern of the mouse Hox-4.3 homeobox gene. (1990) Development. 110(3):733-45.

1989

Dollé, P., Izpisúa-Belmonte, J.C., Falkenstein, H., Renucci, A., Duboule, D. Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation. (1989) Nature. 342(6251):767-72. DOI: 10.1038/342767a0