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Sayin, V.I., LeBoeuf, S.E., Papagiannakopoulos, T. Targeting Metabolic Bottlenecks in Lung Cancer. (2019) Trends in Cancer. 5(8):457-459. DOI: 10.1016/j.trecan.2019.06.001

Lignitto, L., LeBoeuf, S.E., Homer, H., Jiang, S., Askenazi, M., Karakousi, T.R., Pass, H.I., Bhutkar, A.J., Tsirigos, A., Ueberheide, B., Sayin, V.I., Papagiannakopoulos, T., Pagano, M. Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1. (2019) Cell. 178(2):316-329.e18. DOI: 10.1016/j.cell.2019.06.003

McLoughlin, M.R., Orlicky, D.J., Prigge, J.R., Krishna, P., Talago, E.A., Cavigli, I.R., Eriksson, S., Miller, C.G., Kundert, J.A., Sayin, V.I., Sabol, R.A., Heinemann, J., Brandenberger, L.O., Iverson, S.V., Bothner, B., Papagiannakopoulos, T., Shearn, C.T., Arnér, E.S.J., Schmidt, E.E. TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy. (2019) Proceedings of the National Academy of Sciences of the United States of America. 116(23):11408-11417. DOI: 10.1073/pnas.1903244116

Hamza, B., Ng, S.R., Prakadan, S.M., Delgado, F.F., Chin, C.R., King, E.M., Yang, L.F., Davidson, S.M., DeGouveia, K.L., Cermak, N., Navia, A.W., Winter, P.S., Drake, R.S., Tammela, T., Li, C.M., Papagiannakopoulos, T., Gupta, A.J., Shaw Bagnall, J., Knudsen, S.M., Vander Heiden, M.G., Wasserman, S.C., Jacks, T., Shalek, A.K., Manalis, S.R. Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer. (2019) Proceedings of the National Academy of Sciences of the United States of America. 116(6):2232-2236. DOI: 10.1073/pnas.1814102116

Garcia-Bermudez, J., Baudrier, L., La, K., Zhu, X.G., Fidelin, J., Sviderskiy, V.O., Papagiannakopoulos, T., Molina, H., Snuderl, M., Lewis, C.A., Possemato, R.L., Birsoy, K. Publisher Correction: Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. (2018) Nature Cell Biology. 20(10):1228. DOI: 10.1038/s41556-018-0184-2

Snuderl, M., Kannan, K., Pfaff, E., Wang, S., Stafford, J.M., Serrano, J., Heguy, A., Ray, K., Faustin, A., Aminova, O., Dolgalev, I., Stapleton, S.L., Zagzag, D., Chiriboga, L., Gardner, S.L., Wisoff, J.H., Golfinos, J.G., Capper, D., Hovestadt, V., Rosenblum, M.K., Placantonakis, D.G., LeBoeuf, S.E., Papagiannakopoulos, T.Y., Chavez, L., Ahsan, S., Eberhart, C.G., Pfister, S.M., Jones, D.T.W., Karajannis, M.A. Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma. (2018) Nature Communications. 9(1):2868. DOI: 10.1038/s41467-018-05029-3

Garcia-Bermudez, J., Baudrier, L., La, K., Zhu, X.G., Fidelin, J., Sviderskiy, V.O., Papagiannakopoulos, T., Molina, H., Snuderl, M., Lewis, C.A., Possemato, R.L., Birsoy, K. Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. (2018) Nature Cell Biology. 20(7):775-781. DOI: 10.1038/s41556-018-0118-z

Petersen, D.R., Saba, L.M., Sayin, V.I., Papagiannakopoulos, T., Schmidt, E.E., Merrill, G.F., Orlicky, D.J., Shearn, C.T. Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice. (2018) PLOS One. 13(5):e0198139. DOI: 10.1371/journal.pone.0198139

Minton, D.R., Nam, M., McLaughlin, D.J., Shin, J., Bayraktar, E.C., Alvarez, S.W., Sviderskiy, V.O., Papagiannakopoulos, T., Sabatini, D.M., Birsoy, K., Possemato, R. Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs. (2018) Molecular Cell. 69(4):610-621.e5. DOI: 10.1016/j.molcel.2018.01.024

Alvarez, S.W., Sviderskiy, V.O., Terzi, E.M., Papagiannakopoulos, T., Moreira, A.L., Adams, S., Sabatini, D.M., Birsoy, K., Possemato, R. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis. (2017) Nature. 551(7682):639-643. DOI: 10.1038/nature24637

Romero, R., Sayin, V.I., Davidson, S.M., Bauer, M.R., Singh, S.X., LeBoeuf, S.E., Karakousi, T.R., Ellis, D.C., Bhutkar, A., Sánchez-Rivera, F.J., Subbaraj, L., Martinez, B., Bronson, R.T., Prigge, J.R., Schmidt, E.E., Thomas, C.J., Goparaju, C., Davies, A., Dolgalev, I., Heguy, A., Allaj, V., Poirier, J.T., Moreira, A.L., Rudin, C.M., Pass, H.I., Vander Heiden, M.G., Jacks, T., Papagiannakopoulos, T. Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis. (2017) Nature Medicine. 23(11):1362-1368. DOI: 10.1038/nm.4407

Sayin, V.I., LeBoeuf, S.E., Singh, S.X., Davidson, S.M., Biancur, D., Guzelhan, B.S., Alvarez, S.W., Wu, W.L., Karakousi, T.R., Zavitsanou, A.M., Ubriaco, J., Muir, A., Karagiannis, D., Morris, P.J., Thomas, C.J., Possemato, R., Vander Heiden, M.G., Papagiannakopoulos, T. Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer. (2017) Elife. 6. DOI: 10.7554/eLife.28083

Sayin, V.I., Papagiannakopoulos, T. Application of CRISPR-mediated genome engineering in cancer research. (2017) Cancer Letters. 387:10-17. DOI: 10.1016/j.canlet.2016.03.029

Ashouri, A., Sayin, V.I., Van den Eynden, J., Singh, S.X., Papagiannakopoulos, T., Larsson, E. Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events. (2016) Nature Communications. 7:13197. DOI: 10.1038/ncomms13197

Mayers, J.R., Torrence, M.E., Danai, L.V., Papagiannakopoulos, T., Davidson, S.M., Bauer, M.R., Lau, A.N., Ji, B.W., Dixit, P.D., Hosios, A.M., Muir, A., Chin, C.R., Freinkman, E., Jacks, T., Wolpin, B.M., Vitkup, D., Vander Heiden, M.G. Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. (2016) Science. 353(6304):1161-5. DOI: 10.1126/science.aaf5171

Papagiannakopoulos, T.*, Bauer, M.R., Davidson, S.M., Heimann, M., Subbaraj, L., Bhutkar, A., Bartlebaugh, J., Vander Heiden, M.G., Jacks, T. Circadian Rhythm Disruption Promotes Lung Tumorigenesis. (2016) Cell Metabolism. 24(2):324-31. DOI: 10.1016/j.cmet.2016.07.001

Masri, S., Papagiannakopoulos, T., Kinouchi, K., Liu, Y., Cervantes, M., Baldi, P., Jacks, T., Sassone-Corsi, P. Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis. (2016) Cell. 165(4):896-909. DOI: 10.1016/j.cell.2016.04.039

Davidson, S.M., Papagiannakopoulos, T., Olenchock, B.A., Heyman, J.E., Keibler, M.A., Luengo, A., Bauer, M.R., Jha, A.K., O'Brien, J.P., Pierce, K.A., Gui, D.Y., Sullivan, L.B., Wasylenko, T.M., Subbaraj, L., Chin, C.R., Stephanopolous, G., Mott, B.T., Jacks, T., Clish, C.B., Vander Heiden, M.G. Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer. (2016) Cell Metabolism. 23(3):517-28. DOI: 10.1016/j.cmet.2016.01.007

Akama-Garren, E.H., Joshi, N.S., Tammela, T., Chang, G.P., Wagner, B.L., Lee, D.Y., Rideout, W.M., Papagiannakopoulos, T., Xue, W., Jacks, T. A Modular Assembly Platform for Rapid Generation of DNA Constructs. (2016) Scientific Reports. 6:16836. DOI: 10.1038/srep16836

Sánchez-Rivera, F.J., Papagiannakopoulos, T., Romero, R., Tammela, T., Bauer, M.R., Bhutkar, A., Joshi, N.S., Subbaraj, L., Bronson, R.T., Xue, W., Jacks, T. Rapid modelling of cooperating genetic events in cancer through somatic genome editing. (2014) Nature. 516(7531):428-31. DOI: 10.1038/nature13906

Mayers, J.R., Wu, C., Clish, C.B., Kraft, P., Torrence, M.E., Fiske, B.P., Yuan, C., Bao, Y., Townsend, M.K., Tworoger, S.S., Davidson, S.M., Papagiannakopoulos, T., Yang, A., Dayton, T.L., Ogino, S., Stampfer, M.J., Giovannucci, E.L., Qian, Z.R., Rubinson, D.A., Ma, J., Sesso, H.D., Gaziano, J.M., Cochrane, B.B., Liu, S., Wactawski-Wende, J., Manson, J.E., Pollak, M.N., Kimmelman, A.C., Souza, A., Pierce, K., Wang, T.J., Gerszten, R.E., Fuchs, C.S., Vander Heiden, M.G., Wolpin, B.M. Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. (2014) Nature Medicine. 20(10):1193-1198. DOI: 10.1038/nm.3686

Xue, W., Chen, S., Yin, H., Tammela, T., Papagiannakopoulos, T., Joshi, N.S., Cai, W., Yang, G., Bronson, R., Crowley, D.G., Zhang, F., Anderson, D.G., Sharp, P.A., Jacks, T. CRISPR-mediated direct mutation of cancer genes in the mouse liver. (2014) Nature. 514(7522):380-4. DOI: 10.1038/nature13589

McFadden, D.G., Papagiannakopoulos, T., Taylor-Weiner, A., Stewart, C., Carter, S.L., Cibulskis, K., Bhutkar, A., McKenna, A., Dooley, A., Vernon, A., Sougnez, C., Malstrom, S., Heimann, M., Park, J., Chen, F., Farago, A.F., Dayton, T., Shefler, E., Gabriel, S., Getz, G., Jacks, T. Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing. (2014) Cell. 156(6):1298-1311. DOI: 10.1016/j.cell.2014.02.031

Papagiannakopoulos, T.*, Friedmann-Morvinski, D., Neveu, P., Dugas, J.C., Gill, R.M., Huillard, E., Liu, C., Zong, H., Rowitch, D.H., Barres, B.A., Verma, I.M., Kosik, K.S. Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases. (2012) Oncogene. 31(15):1884-95. DOI: 10.1038/onc.2011.380

Papagiannakopoulos, T.*, Kosik, K.S. MicroRNA-124: micromanager of neurogenesis. (2009) Cell Stem Cell. 4(5):375-6. DOI: 10.1016/j.stem.2009.04.007

Xu, N., Papagiannakopoulos, T., Pan, G., Thomson, J.A., Kosik, K.S. MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. (2009) Cell. 137(4):647-58. DOI: 10.1016/j.cell.2009.02.038

Carrettiero, D.C., Hernandez, I., Neveu, P., Papagiannakopoulos, T., Kosik, K.S. The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule. (2009) Journal of Neuroscience. 29(7):2151-61. DOI: 10.1523/JNEUROSCI.4660-08.2009

Papagiannakopoulos, T.*, Shapiro, A., Kosik, K.S. MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. (2008) Cancer Research. 68(19):8164-72. DOI: 10.1158/0008-5472.CAN-08-1305

Papagiannakopoulos, T.*, Kosik, K.S. MicroRNAs: regulators of oncogenesis and stemness. (2008) BMC Med. 6:15. DOI: 10.1186/1741-7015-6-15

Partridge, J.J., Madsen, M.A., Ardi, V.C., Papagiannakopoulos, T., Kupriyanova, T.A., Quigley, J.P., Deryugina, E.I. Functional analysis of matrix metalloproteinases and tissue inhibitors of metalloproteinases differentially expressed by variants of human HT-1080 fibrosarcoma exhibiting high and low levels of intravasation and metastasis. (2007) Journal of Biological Chemistry. 282(49):35964-77. DOI: 10.1074/jbc.M705993200

Liu, T., Papagiannakopoulos, T., Puskar, K., Qi, S., Santiago, F., Clay, W., Lao, K., Lee, Y., Nelson, S.F., Kornblum, H.I., Doyle, F., Petzold, L., Shraiman, B., Kosik, K.S. Detection of a microRNA signal in an in vivo expression set of mRNAs. (2007) PLOS One. 2(8):e804. DOI: 10.1371/journal.pone.0000804

Deryugina, E.I., Zijlstra, A., Partridge, J.J., Kupriyanova, T.A., Madsen, M.A., Papagiannakopoulos, T., Quigley, J.P. Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination. (2005) Cancer Research. 65(23):10959-69. DOI: 10.1158/0008-5472.CAN-05-2228