Susan Kaech

Professor and Director

Nomis Foundation Laboratories for Immunobiology and Microbial Pathogenesis

Salk Institute for Biological Studies - Publications

List of Publications


FoxO1 directly regulates the expression of PD-1 and sustains viral specific CD8+ T-cell responses during chronic infection.
Staron M, Gray S, Li MO, Ip WK, Kaech SM. FoxO1 directly regulates the expression of PD-1 and sustains viral specific CD8+ T-cell responses during chronic infection. Immunity 41(5) 802-14 (2014). PMCID in Progress

CD4 T cells required for development and function of tissue resident memory CD8 T cells through a T-bet-dependent mechanism.
Laidlaw BJ, Zhang N, Craft J, Kaech SM. CD4 T cells required for development and function of tissue resident memory CD8 T cells through a T-bet-dependent mechanism. Immunity 41(4):633-45 (2014). PMCID in Progress.

Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ.
Ho PC, Meeth KM, Tsui YC, Srivastava B, Bosenberg MW, Kaech SM. Immune-based antitumor effects of BRAF Inhibitors rely on signaling by CD40L and IFN-?. Cancer Res, 74(12):3205-17 (2014). PMCID: PMC4063281.

TLR4 ligands LPS and MPLA differentially regulate effector and memory CD8+ T cell differentiation.
Cui W, Joshi NS, Liu Y, Meng H, Kleinstein SH and Kaech SM. TLR4 ligands LPS and MPLA differentially regulate effector and memory CD8+ T cell differentiation. J Immunol, 92(9):4221-32 (2014). PMCID: PMC4071140.

Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells.
Ray JP, Marshall HD, Laidlaw BJ, Staron MM, Kaech SM, Craft J. Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells. Immunity 40(3):367-77 (2014). PMCID: PMC3992517.

Parish, IA, Marshall HD, Staron M, Lang PA, Brüstle A, Chen JH, Cui W, Ohashi PS, Weaver CT and Kaech SM. Blimp-1 triggers the formation of immunoregulatory IL-10 producing Th1 cells during chronic viral infection. J Clin Invest, 124(8):3455-68 (2014). PMCID: PMC4109559.

Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype.
Demento SL, Cui W, Criscione JM, Stern E, Tulipan J, Kaech SM, Fahmy TM. Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype. Biomaterials. 19:4957-64 (2012). PMID:224840449. PMCID in Progress.

An IL-21/IL-10/STAT3 pathway is critical for functional maturation of memory CD8+ T cells.
Cui W, Liu Y, Weinstein JS, Craft J & Kaech SM. An IL-21/IL-10/STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity 35:792-805 (2011). PMCID in progress.

Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4(+) Cell Properties during Viral Infection.
Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA, Rustishauser R, Cui W, Kleinstein SH, Craft J and Kaech SM. Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4(+) Cell Properties during Viral Infection. Immunity 35:633-46 (2011). PMCID in process.

Increased numbers of pre-existing memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells.
Joshi NS, Cui W, Dominguez CX, Chen JH, Hand TW and Kaech SM. Increased numbers of pre-existing memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells. J Immunol 187(8):4068-76 (2011). PMCID in process.

Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection.
Jung YW, Rutishauser R, Nikhil JS, Haberman AM and Kaech SM. Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection. J Immunol 185:5315-25 (2010). PMCID in progress.

Differential effects of STAT5 and P13K/AKT signaling on effector and memory CD8 T cell survival.
Hand TW, Jung YW, Cui W, Sefik E, Liu Y, Joshi NS, Chandele A and Kaech SM. Differential effects of STAT5 and P13K/AKT signaling on effector and memory CD8 T cell survival. PNAS 107:16601-6 (2010). PMCID: PMC2944719.

In vivo regulation of Bcl6 and T follicular helper cell development.
Poholek AC, Hansen K, Hernandez SG, Eto D, Chandele A, Dong, X, Odegard JM, Kaech SM, Dent AL, Crotty S and Craft J. Bcl6 regulation and TFH cell development. J Immunol 185:313-26 (2010). PMCID: PMC2891136.

Blimp-1 is Required for the Terminal Differentiation of Virus-Specific Effector and Memory CD8 T cells.
Rutishauser RL, Martins GA, Kalachikov S, Chandele A, Parish IA, Jacob J, Calame K, Kaech SM. Blimp-1 is Required for the Terminal Differentiation of Virus-Specific Effector and Memory CD8 T cells. Immunity 31: 296-308 (2009).

Effects of Signal 3 during CD8 T cell priming: Bystander Production of IL-12 enhances effector T cell expansion but promotes terminal differentiation.
Cui W, Joshi NS, Jiang A, Whitmire JK, Whitton JL, Kaech SM. Vaccine. 2009 Mar 26;27(15):2177-87. doi: 10.1016/j.vaccine.2009.01.088. Epub 2009 Feb 6.

Formation of IL-7Rahi and IL-7Ralo CD8 T Cells during Infection is Regulated by the Opposing Functions of GABPa and Gfi-1.
Chandele A, Joshi NS, Zhu J, Paul WE, Leonard WJ, Kaech SM. Formation of IL-7Rahi and IL-7Ralo CD8 T Cells during Infection is Regulated by the Opposing Functions of GABPa and Gfi-1. J Immunol 8: 5309-19 (2008). PMID: 18390712.

Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-Bet Transcription Factor.
Joshi NS, Cui W, Chandele A, Heung K-L, Urso D, Hagman J, Gapin L, Kaech SM. Immunity. 2007 Aug;27(2):281-95.

Heterogeneity and Cell Fate Decisions in Effector and Memory CD8+ T Cell Differentiation During Viral Infection.
Kaech SM and Wherry EJ. Heterogeneity and Cell Fate Decisions in Effector and Memory CD8+ T Cell Differentiation During Viral Infection. Immunity 27:393-405 (2007). PMID: 17892848.

Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection.
Hand T, Morre M, Kaech SM. Expression of Interleukin-7 Receptor a Is Necessary but not Sufficient for the Formation of Memory CD8 T Cells During Viral Infection. PNAS 104: 11730-11735 (2007). PMID: 17609371.

Selective expression of the IL-7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.
Kaech, S.M., Tan, J.T., Wherry, E.J., Konieczny, B.T., Surh, C.D., and Ahmed, R. (2003). Selective expression of the IL-7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nature Immunol. 4:1191-98.

Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.
Laidlaw BJ, Cui W, Amezquita RA, Gray SM, Guan T, Lu Y, Kobayashi Y, Flavell RA, Kleinstein SH, Craft J, Kaech SM. Nat Immunol. 2015 Aug;16(8):871-9.

Education

PhD, Developmental Biology, Stanford University
BS, Cellular and Molecular Biology, University of Washington, Seattle, WA


Awards & Honors

  • 2009 Howard Hughes Early Career Scientist
  • 2007 Presidential Early Career Award for Scientists and Engineers (PECASE)
  • 2007 American Asthma Foundation Investigator
  • 2005 Cancer Research Institute Investigator Award
  • 2005 Edward Mallinckrodt Jr. Foundation Award
  • 2003 Burroughs-Wellcome Foundation Award in Biomedical Sciences
  • 1999 Damon Runyon-Walter Winchell Cancer Research Fellowship
  • 1993 National Science Foundation Predoctoral Fellowship