Susan Kaech

Professor and Director

NOMIS Center for Immunobiology and Microbial Pathogenesis

NOMIS Chair

Salk Institute for Biological Studies - Publications

all Publications


Varanasi, S.K., Ma, S., Kaech, S.M. T Cell Metabolism in a State of Flux. (2019) Immunity. 51(5):783-785. DOI: 10.1016/j.immuni.2019.10.012

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Harel, M., Ortenberg, R., Varanasi, S.K., Mangalhara, K.C., Mardamshina, M., Markovits, E., Baruch, E.N., Tripple, V., Arama-Chayoth, M., Greenberg, E., Shenoy, A., Ayasun, R., Knafo, N., Xu, S., Anafi, L., Yanovich-Arad, G., Barnabas, G.D., Ashkenazi, S., Besser, M.J., Schachter, J., Bosenberg, M., Shadel, G.S., Barshack, I., Kaech, S.M., Markel, G., Geiger, T. Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence. (2019) Cell. DOI: 10.1016/j.cell.2019.08.012

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Mann, T.H., Kaech, S.M. Tick-TOX, it's time for T cell exhaustion (2019) Nature Immunology. 20(9):1092-1094. DOI: 10.1038/s41590-019-0478-y

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Ayeni, D., Miller, B., Kuhlmann, A., Ho, P.C., Robles-Oteiza, C., Gaefele, M., Levy, S., de Miguel, F.J., Perry, C., Guan, T., Krystal, G., Lockwood, W., Zelterman, D., Homer, R., Liu, Z., Kaech, S., Politi, K. Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors. (2019) Journal for Immunotherapy of Cancer. 7(1):172. DOI: 10.1186/s40425-019-0643-8

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Myers, L.M., Tal, M.C., Torrez Dulgeroff, L.B., Carmody, A.B., Messer, R.J., Gulati, G., Yiu, Y.Y., Staron, M.M., Angel, C.L., Sinha, R., Markovic, M., Pham, E.A., Fram, B., Ahmed, A., Newman, A.M., Glenn, J.S., Davis, M.M., Kaech, S.M., Weissman, I.L., Hasenkrug, K.J. A functional subset of CD8 T cells during chronic exhaustion is defined by SIRPα expression. (2019) Nature Communications. 10(1):794. DOI: 10.1038/s41467-019-08637-9

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Kaech, S.M. T-bet in Tfh cells: Now you see me, now you don't. (2018) J. Exp. Med.:2697-2698 DOI: 10.1084/jem.20181878

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Fan, M.Y., Low, J.S., Tanimine, N., Finn, K.K., Priyadharshini, B., Germana, S.K., Kaech, S.M., Turka, L.A. Differential Roles of IL-2 Signaling in Developing versus Mature Tregs. (2018) Cell Reports. 25(5):1204-1213.e4. DOI: 10.1016/j.celrep.2018.10.002

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Pereira, F.V., Melo, A.C.L., Low, J.S., de Castro, I.A., Braga, T.T., Almeida, D.C., Batista de Lima, A.G.U., Hiyane, M.I., Correa-Costa, M., Andrade-Oliveira, V., Origassa, C.S.T., Pereira, R.M., Kaech, S.M., Rodrigues, E.G., Câmara, N.O.S. Metformin exerts antitumor activity via induction of multiple death pathways in tumor cells and activation of a protective immune response. (2018) Oncotarget. 9(40):25808-25825. DOI: 10.18632/oncotarget.25380

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Herndler-Brandstetter, D., Ishigame, H., Shinnakasu, R., Plajer, V., Stecher, C., Zhao, J., Lietzenmayer, M., Kroehling, L., Takumi, A., Kometani, K., Inoue, T., Kluger, Y., Kaech, S.M., Kurosaki, T., Okada, T., Flavell, R.A. KLRG1 Effector CD8 T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. (2018) Immunity. 48(4):716-729.e8. DOI: 10.1016/j.immuni.2018.03.015

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Guan, T., Dominguez, C.X., Amezquita, R.A., Laidlaw, B.J., Cheng, J., Henao-Mejia, J., Williams, A., Flavell, R.A., Lu, J., Kaech, S.M. ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8 T cell fates. (2018) Journal of Experimental Medicine. 215(4):1153-1168. DOI: 10.1084/jem.20171352

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Perry, C.J., Muñoz-Rojas, A.R., Meeth, K.M., Kellman, L.N., Amezquita, R.A., Thakral, D., Du, V.Y., Wang, J.X., Damsky, W., Kuhlmann, A.L., Sher, J.W., Bosenberg, M., Miller-Jensen, K., Kaech, S.M. Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity. (2018) Journal of Experimental Medicine. 215(3):877-893. DOI: 10.1084/jem.20171435

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Low, J.S., Kaech, S.M. Trials and Tribble-ations of tissue T cells. (2018) Nature Immunology. 19(2):102-103. DOI: 10.1038/s41590-017-0031-9


Weinstein, J.S., Laidlaw, B.J., Lu, Y., Wang, J.K., Schulz, V.P., Li, N., Herman, E.I., Kaech, S.M., Gallagher, P.G., Craft, J. STAT4 and T-bet control follicular helper T cell development in viral infections. (2018) Journal of Experimental Medicine. 215(1):337-355. DOI: 10.1084/jem.20170457

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Gettinger, S., Choi, J., Hastings, K., Truini, A., Datar, I., Sowell, R., Wurtz, A., Dong, W., Cai, G., Melnick, M.A., Du, V.Y., Schlessinger, J., Goldberg, S.B., Chiang, A., Sanmamed, M.F., Melero, I., Agorreta, J., Montuenga, L.M., Lifton, R., Ferrone, S., Kavathas, P., Rimm, D.L., Kaech, S.M., Schalper, K., Herbst, R.S., Politi, K. Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer. (2017) Cancer Discovery. 7(12):1420-1435. DOI: 10.1158/2159-8290.CD-17-0593

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Laidlaw, B.J., Lu, Y., Amezquita, R.A., Weinstein, J.S., Vander Heiden, J.A., Gupta, N.T., Kleinstein, S.H., Kaech, S.M., Craft, J. Interleukin-10 from CD4 follicular regulatory T cells promotes the germinal center response. (2017) Science Immunology. 2(16). DOI: 10.1126/sciimmunol.aan4767

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Yeon, S.M., Halim, L., Chandele, A., Perry, C.J., Kim, S.H., Kim, S.U., Byun, Y., Yuk, S.H., Kaech, S.M., Jung, Y.W. IL-7 plays a critical role for the homeostasis of allergen-specific memory CD4 T cells in the lung and airways. (2017) Scientific Reports. 7(1):11155. DOI: 10.1038/s41598-017-11492-7

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Shin, H.M., Kapoor, V.N., Kim, G., Li, P., Kim, H.R., Suresh, M., Kaech, S.M., Wherry, E.J., Selin, L.K., Leonard, W.J., Welsh, R.M., Berg, L.J. Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory. (2017) PLOS pathogens. 13(8):e1006544. DOI: 10.1371/journal.ppat.1006544

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Roberts, N.A., Adams, B.D., McCarthy, N.I., Tooze, R.M., Parnell, S.M., Anderson, G., Kaech, S.M., Horsley, V. Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity. (2017) Journal of Immunology. 199(4):1250-1260. DOI: 10.4049/jimmunol.1600941

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Wang, J., Perry, C.J., Meeth, K., Thakral, D., Damsky, W., Micevic, G., Kaech, S., Blenman, K., Bosenberg, M. UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model. (2017) Pigment Cell & Melanoma Research. 30(4):428-435. DOI: 10.1111/pcmr.12591

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Ho, P.C., Kaech, S.M. Reenergizing T cell anti-tumor immunity by harnessing immunometabolic checkpoints and machineries. (2017) Current Opinion in Immunology. 46:38-44. DOI: 10.1016/j.coi.2017.04.003

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Buck, M.D., Sowell, R.T., Kaech, S.M., Pearce, E.L. Metabolic Instruction of Immunity. (2017) Cell. 169(4):570-586. DOI: 10.1016/j.cell.2017.04.004

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Hajek, M., Sewell, A., Kaech, S., Burtness, B., Yarbrough, W.G., Issaeva, N. TRAF3/CYLD mutations identify a distinct subset of human papillomavirus-associated head and neck squamous cell carcinoma. (2017) Cancer. 123(10):1778-1790. DOI: 10.1002/cncr.30570

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Gray, S.M., Amezquita, R.A., Guan, T., Kleinstein, S.H., Kaech, S.M. Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8 T Cell Terminal Differentiation and Loss of Multipotency. (2017) Immunity. 46(4):596-608. DOI: 10.1016/j.immuni.2017.03.012

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Amezquita, R.A., Kaech, S.M. Immunology: The chronicles of T-cell exhaustion. (2017) Nature. 543(7644):190-191. DOI: 10.1038/nature21508


Poholek, A.C., Jankovic, D., Villarino, A.V., Petermann, F., Hettinga, A., Shouval, D.S., Snapper, S.B., Kaech, S.M., Brooks, S.R., Vahedi, G., Sher, A., Kanno, Y., O'Shea, J.J. IL-10 induces a STAT3-dependent autoregulatory loop in T2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes. (2016) Science Immunology. 1(5).

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Adams, N.M., O'Sullivan, T.E., Geary, C.D., Karo, J.M., Amezquita, R.A., Joshi, N.S., Kaech, S.M., Sun, J.C. NK Cell Responses Redefine Immunological Memory. (2016) Journal of Immunology. 197(8):2963-2970. DOI: 10.4049/jimmunol.1600973

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Boddupalli, C.S., Nair, S., Gray, S.M., Nowyhed, H.N., Verma, R., Gibson, J.A., Abraham, C., Narayan, D., Vasquez, J., Hedrick, C.C., Flavell, R.A., Dhodapkar, K.M., Kaech, S.M., Dhodapkar, M.V. ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells. (2016) Journal of Clinical Investigation. 126(10):3905-3916. DOI: 10.1172/JCI85329

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Sowell, R.T., Kaech, S.M. Probing the Diversity of T Cell Dysfunction in Cancer. (2016) Cell. 166(6):1362-1364. DOI: 10.1016/j.cell.2016.08.058

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Kritikou, J.S., Dahlberg, C.I., Baptista, M.A., Wagner, A.K., Banerjee, P.P., Gwalani, L.A., Poli, C., Panda, S.K., Kärre, K., Kaech, S.M., Wermeling, F., Andersson, J., Orange, J.S., Brauner, H., Westerberg, L.S. IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo. (2016) Scientific Reports. 6:30636. DOI: 10.1038/srep30636

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Jung, Y.W., Kim, H.G., Perry, C.J., Kaech, S.M. CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7- and IL-15-dependent niches. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(29):8278-83. DOI: 10.1073/pnas.1602899113

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Garyu, J.W., Uduman, M., Stewart, A., Rui, J., Deng, S., Shenson, J., Staron, M.M., Kaech, S.M., Kleinstein, S.H., Herold, K.C. Characterization of Diabetogenic CD8+ T Cells: IMMUNE THERAPY WITH METABOLIC BLOCKADE. (2016) Journal of Biological Chemistry. 291(21):11230-40. DOI: 10.1074/jbc.M115.713362

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Xin, A., Masson, F., Liao, Y., Preston, S., Guan, T., Gloury, R., Olshansky, M., Lin, J.X., Li, P., Speed, T.P., Smyth, G.K., Ernst, M., Leonard, W.J., Pellegrini, M., Kaech, S.M., Nutt, S.L., Shi, W., Belz, G.T., Kallies, A. A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet. (2016) Nature Immunology. 17(4):422-32. DOI: 10.1038/ni.3410

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Laidlaw, B.J., Craft, J.E., Kaech, S.M. The multifaceted role of CD4(+) T cells in CD8(+) T cell memory. (2016) Nature Reviews. Immunology. 16(2):102-11. DOI: 10.1038/nri.2015.10

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Dominguez, C.X., Amezquita, R.A., Guan, T., Marshall, H.D., Joshi, N.S., Kleinstein, S.H., Kaech, S.M. The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection. (2015) J. Exp. Med. 212(12):2041-56. DOI: 10.1084/jem.20150186

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Ray, J.P., Staron, M.M., Shyer, J.A., Ho, P.C., Marshall, H.D., Gray, S.M., Laidlaw, B.J., Araki, K., Ahmed, R., Kaech, S.M., Craft, J. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. (2015) Immunity. 43(4):690-702. DOI: 10.1016/j.immuni.2015.08.017

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Ho, P.C., Bihuniak, J.D., Macintyre, A.N., Staron, M., Liu, X., Amezquita, R., Tsui, Y.C., Cui, G., Micevic, G., Perales, J.C., Kleinstein, S.H., Abel, E.D., Insogna, K.L., Feske, S., Locasale, J.W., Bosenberg, M.W., Rathmell, J.C., Kaech, S.M. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. (2015) Cell. 162(6):1217-28. DOI: 10.1016/j.cell.2015.08.012

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Laidlaw, B.J., Cui, W., Amezquita, R.A., Gray, S.M., Guan, T., Lu, Y., Kobayashi, Y., Flavell, R.A., Kleinstein, S.H., Craft, J., Kaech, S.M. Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells. (2015) Nature Immunology. 16(8):871-9. DOI: 10.1038/ni.3224

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Cui, G., Staron, M.M., Gray, S.M., Ho, P.C., Amezquita, R.A., Wu, J., Kaech, S.M. IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity. (2015) Cell. 161(4):750-61. DOI: 10.1016/j.cell.2015.03.021

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West, A.P., Khoury-Hanold, W., Staron, M., Tal, M.C., Pineda, C.M., Lang, S.M., Bestwick, M., Duguay, B.A., Raimundo, N., MacDuff, D.A., Kaech, S.M., Smiley, J.R., Means, R.E., Iwasaki, A., Shadel, G.S. Mitochondrial DNA stress primes the antiviral innate immune response. (2015) Nature. 520(7548):553-7. DOI: 10.1038/nature14156

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Chen, J.H., Perry, C.J., Tsui, Y.C., Staron, M.M., Parish, I.A., Dominguez, C.X., Rosenberg, D.W., Kaech, S.M. Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection. (2015) Nature Medicine. 21(4):327-34. DOI: 10.1038/nm.3831

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Mohanty, S., Joshi, S.R., Ueda, I., Wilson, J., Blevins, T.P., Siconolfi, B., Meng, H., Devine, L., Raddassi, K., Tsang, S., Belshe, R.B., Hafler, D.A., Kaech, S.M., Kleinstein, S.H., Trentalange, M., Allore, H.G., Shaw, A.C. Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults. (2015) J. Infect. Dis. 211(7):1174-84. DOI: 10.1093/infdis/jiu573

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Hu, Y., Lee, Y.T., Kaech, S.M., Garvy, B., Cauley, L.S. Smad4 promotes differentiation of effector and circulating memory CD8 T cells but is dispensable for tissue-resident memory CD8 T cells. (2015) Journal of immunology. 194(5):2407-14. DOI: 10.4049/jimmunol.1402369

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Perry, R.J., Camporez, J.G., Kursawe, R., Titchenell, P.M., Zhang, D., Perry, C.J., Jurczak, M.J., Abudukadier, A., Han, M.S., Zhang, X.M., Ruan, H.B., Yang, X., Caprio, S., Kaech, S.M., Sul, H.S., Birnbaum, M.J., Davis, R.J., Cline, G.W., Petersen, K.F., Shulman, G.I. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. (2015) Cell. 160(4):745-758. DOI: 10.1016/j.cell.2015.01.012

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Thakar, J., Mohanty, S., West, A.P., Joshi, S.R., Ueda, I., Wilson, J., Meng, H., Blevins, T.P., Tsang, S., Trentalange, M., Siconolfi, B., Park, K., Gill, T.M., Belshe, R.B., Kaech, S.M., Shadel, G.S., Kleinstein, S.H., Shaw, A.C. Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination. (2015) Aging (Albany NY). 7(1):38-52. DOI: 10.18632/aging.100720

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Marshall, H.D., Ray, J.P., Laidlaw, B.J., Zhang, N., Gawande, D., Staron, M.M., Craft, J., Kaech, S.M. The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa. (2015) Elife. 4:e04851. DOI: 10.7554/eLife.04851

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Backer, R.A., Helbig, C., Gentek, R., Kent, A., Laidlaw, B.J., Dominguez, C.X., de Souza, Y.S., van Trierum, S.E., van Beek, R., Rimmelzwaan, G.F., ten Brinke, A., Willemsen, A.M., van Kampen, A.H., Kaech, S.M., Blander, J.M., van Gisbergen, K., Amsen, D. A central role for Notch in effector CD8(+) T cell differentiation. (2014) Nature Immunology. 15(12):1143-51. DOI: 10.1038/ni.3027

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Staron, M.M., Gray, S.M., Marshall, H.D., Parish, I.A., Chen, J.H., Perry, C.J., Cui, G., Li, M.O., Kaech, S.M. The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection. (2014) Immunity. 41(5):802-14. DOI: 10.1016/j.immuni.2014.10.013

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Laidlaw, B.J., Zhang, N., Marshall, H.D., Staron, M.M., Guan, T., Hu, Y., Cauley, L.S., Craft, J., Kaech, S.M. CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. (2014) Immunity. 41(4):633-45. DOI: 10.1016/j.immuni.2014.09.007

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Shaw, P.J., Weidinger, C., Vaeth, M., Luethy, K., Kaech, S.M., Feske, S. CD4⁺ and CD8⁺ T cell-dependent antiviral immunity requires STIM1 and STIM2. (2014) Journal of Clinical Investigation. 124(10):4549-63. DOI: 10.1172/JCI76602

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Gray, S.M., Kaech, S.M., Staron, M.M. The interface between transcriptional and epigenetic control of effector and memory CD8⁺ T-cell differentiation. (2014) Immunol. Rev. 261(1):157-68. DOI: 10.1111/imr.12205

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Gate, D., Danielpour, M., Rodriguez, J., Kim, G.B., Levy, R., Bannykh, S., Breunig, J.J., Kaech, S.M., Flavell, R.A., Town, T. T-cell TGF-β signaling abrogation restricts medulloblastoma progression. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(33):E3458-66. DOI: 10.1073/pnas.1412489111

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Marshall, H.D., Kaech, S.M. Regulating the diverse outcomes of interferon's interference. (2014) Trends in Immunology. 35(8):353-4. DOI: 10.1016/j.it.2014.07.002

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Parish, I.A., Marshall, H.D., Staron, M.M., Lang, P.A., Brüstle, A., Chen, J.H., Cui, W., Tsui, Y.C., Perry, C., Laidlaw, B.J., Ohashi, P.S., Weaver, C.T., Kaech, S.M. Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1. (2014) Journal of Clinical Investigation. 124(8):3455-68. DOI: 10.1172/JCI66108

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Ho, P.C., Kaech, S.M. BRAF-targeted therapy alters the functions of intratumoral CD4 T cells to inhibit melanoma progression. (2014) Oncoimmunology. 3:e29126. DOI: 10.4161/onci.29126

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Cui, W., Joshi, N.S., Liu, Y., Meng, H., Kleinstein, S.H., Kaech, S.M. TLR4 ligands lipopolysaccharide and monophosphoryl lipid a differentially regulate effector and memory CD8+ T Cell differentiation. (2014) Journal of immunology. 192(9):4221-32. DOI: 10.4049/jimmunol.1302569

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Ray, J.P., Marshall, H.D., Laidlaw, B.J., Staron, M.M., Kaech, S.M., Craft, J. Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells. (2014) Immunity. 40(3):367-77. DOI: 10.1016/j.immuni.2014.02.005

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Kaech, S.M. Celebrating diversity in memory T cells. (2014) Journal of Immunology. 192(3):837-9. DOI: 10.4049/jimmunol.1303268


Zhao, Y., Zhao, H., Sun, Y., Hao, J., Qi, X., Zhou, X., Wu, Z., Wang, P., Kaech, S.M., Weaver, C.T., Flavell, R.A., Zhao, L., Yao, Z., Yin, Z. IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism. (2013) Journal of Leukocyte Biology. 94(6):1103-12. DOI: 10.1189/jlb.0213064

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Slütter, B., Pewe, L.L., Kaech, S.M., Harty, J.T. Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus. (2013) Immunity. 39(5):939-48. DOI: 10.1016/j.immuni.2013.09.013

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Shin, H.M., Kapoor, V., Guan, T., Kaech, S.M., Welsh, R.M., Berg, L.J. Epigenetic modifications induced by Blimp-1 Regulate CD8⁺ T cell memory progression during acute virus infection. (2013) Immunity. 39(4):661-75. DOI: 10.1016/j.immuni.2013.08.032

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Marshall, H.D., Kaech, S.M. Generating CD8 T cell heterogeneity: attack of the clones. (2013) Immunity. 39(2):203-5. DOI: 10.1016/j.immuni.2013.08.008

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Henao-Mejia, J., Williams, A., Goff, L.A., Staron, M., Licona-Limón, P., Kaech, S.M., Nakayama, M., Rinn, J.L., Flavell, R.A. The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis. (2013) Immunity. 38(5):984-97. DOI: 10.1016/j.immuni.2013.02.021

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D'Souza, A.D., Parish, I.A., Krause, D.S., Kaech, S.M., Shadel, G.S. Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia. (2013) Molecular Therapy. 21(1):42-8. DOI: 10.1038/mt.2012.203

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Kaech, S.M., Cui, W. Transcriptional control of effector and memory CD8+ T cell differentiation. (2012) Nature Reviews. Immunology. 12(11):749-61. DOI: 10.1038/nri3307

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Demento, S.L., Cui, W., Criscione, J.M., Stern, E., Tulipan, J., Kaech, S.M., Fahmy, T.M. Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype. (2012) Biomaterials. 33(19):4957-64. DOI: 10.1016/j.biomaterials.2012.03.041

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Lang, P.A., Lang, K.S., Xu, H.C., Grusdat, M., Parish, I.A., Recher, M., Elford, A.R., Dhanji, S., Shaabani, N., Tran, C.W., Dissanayake, D., Rahbar, R., Ghazarian, M., Brüstle, A., Fine, J., Chen, P., Weaver, C.T., Klose, C., Diefenbach, A., Häussinger, D., Carlyle, J.R., Kaech, S.M., Mak, T.W., Ohashi, P.S. Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(4):1210-5. DOI: 10.1073/pnas.1118834109

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Cui, W., Liu, Y., Weinstein, J.S., Craft, J., Kaech, S.M. An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. (2011) Immunity. 35(5):792-805. DOI: 10.1016/j.immuni.2011.09.017

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Li, N., Matte-Martone, C., Zheng, H., Cui, W., Venkatesan, S., Tan, H.S., McNiff, J., Demetris, A.J., Roopenian, D., Kaech, S., Shlomchik, W.D. Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution. (2011) Blood. 118(22):5965-76. DOI: 10.1182/blood-2011-07-367011

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Marshall, H.D., Chandele, A., Jung, Y.W., Meng, H., Poholek, A.C., Parish, I.A., Rutishauser, R., Cui, W., Kleinstein, S.H., Craft, J., Kaech, S.M. Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. (2011) Immunity. 35(4):633-46. DOI: 10.1016/j.immuni.2011.08.016

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Joshi, N.S., Cui, W., Dominguez, C.X., Chen, J.H., Hand, T.W., Kaech, S.M. Increased numbers of preexisting memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells. (2011) Journal of immunology. 187(8):4068-76. DOI: 10.4049/jimmunol.1002145

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D'Souza, A.D., Parish, I.A., McKay, S.E., Kaech, S.M., Shadel, G.S. Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling. (2011) American Journal of Pathology. 178(6):2740-51. DOI: 10.1016/j.ajpath.2011.02.022

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Parish, I.A., Kaech, S.M. IL-7 knocks the socs off chronic viral infection. (2011) Cell. 144(4):467-8. DOI: 10.1016/j.cell.2011.01.038

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Jung, Y.W., Rutishauser, R.L., Joshi, N.S., Haberman, A.M., Kaech, S.M. Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection. (2010) Journal of immunology. 185(9):5315-25. DOI: 10.4049/jimmunol.1001948

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Jung, Y.W., Kaech, S.M. Like parent, like child: inheritance of effector CD8+ T cell traits. (2010) Immunity. 33(3):296-8. DOI: 10.1016/j.immuni.2010.09.005

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Hand, T.W., Cui, W., Jung, Y.W., Sefik, E., Joshi, N.S., Chandele, A., Liu, Y., Kaech, S.M. Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(38):16601-6. DOI: 10.1073/pnas.1003457107

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Demento, S.L., Bonafé, N., Cui, W., Kaech, S.M., Caplan, M.J., Fikrig, E., Ledizet, M., Fahmy, T.M. TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. (2010) Journal of Immunology. 185(5):2989-97. DOI: 10.4049/jimmunol.1000768

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Cui, W., Kaech, S.M. Generation of effector CD8+ T cells and their conversion to memory T cells. (2010) Immunological Reviews. 236:151-66. DOI: 10.1111/j.1600-065X.2010.00926.x

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Poholek, A.C., Hansen, K., Hernandez, S.G., Eto, D., Chandele, A., Weinstein, J.S., Dong, X., Odegard, J.M., Kaech, S.M., Dent, A.L., Crotty, S., Craft, J. In vivo regulation of Bcl6 and T follicular helper cell development. (2010) Journal of Immunology. 185(1):313-26. DOI: 10.4049/jimmunol.0904023

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Rutishauser, R.L., Kaech, S.M. Generating diversity: transcriptional regulation of effector and memory CD8 T-cell differentiation. (2010) Immunol. Rev. 235(1):219-33. DOI: 10.1111/j.0105-2896.2010.00901.x

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Hinson, E.R., Joshi, N.S., Chen, J.H., Rahner, C., Jung, Y.W., Wang, X., Kaech, S.M., Cresswell, P. Viperin is highly induced in neutrophils and macrophages during acute and chronic lymphocytic choriomeningitis virus infection. (2010) Journal of immunology. 184(10):5723-31. DOI: 10.4049/jimmunol.0903752

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Rutishauser, R.L., Martins, G.A., Kalachikov, S., Chandele, A., Parish, I.A., Meffre, E., Jacob, J., Calame, K., Kaech, S.M. Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. (2009) Immunity. 31(2):296-308. DOI: 10.1016/j.immuni.2009.05.014

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Parish, I.A., Kaech, S.M. Diversity in CD8(+) T cell differentiation. (2009) Current Opinion in Immunology. 21(3):291-7. DOI: 10.1016/j.coi.2009.05.008

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Hand, T.W., Kaech, S.M. Intrinsic and extrinsic control of effector T cell survival and memory T cell development. (2009) Immunologic Research. 45(1):46-61. DOI: 10.1007/s12026-008-8027-z

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Cui, W., Joshi, N.S., Jiang, A., Kaech, S.M. Effects of Signal 3 during CD8 T cell priming: Bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiation. (2009) Vaccine. 27(15):2177-87. DOI: 10.1016/j.vaccine.2009.01.088

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Whitmire, J.K., Asano, M.S., Kaech, S.M., Sarkar, S., Hannum, L.G., Shlomchik, M.J., Ahmed, R. Requirement of B cells for generating CD4+ T cell memory. (2009) Journal of Immunology. 182(4):1868-76. DOI: 10.4049/jimmunol.0802501

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Rahman, A.H., Cui, W., Larosa, D.F., Taylor, D.K., Zhang, J., Goldstein, D.R., Wherry, E.J., Kaech, S.M., Turka, L.A. MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. (2008) Journal of immunology. 181(6):3804-10.

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Haining, W.N., Ebert, B.L., Subrmanian, A., Wherry, E.J., Eichbaum, Q., Evans, J.W., Mak, R., Rivoli, S., Pretz, J., Angelosanto, J., Smutko, J.S., Walker, B.D., Kaech, S.M., Ahmed, R., Nadler, L.M., Golub, T.R. Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. (2008) Journal of immunology. 181(3):1859-68.

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Chandele, A., Joshi, N.S., Zhu, J., Paul, W.E., Leonard, W.J., Kaech, S.M. Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1. (2008) Journal of Immunology. 180(8):5309-19.

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Joshi, N.S., Kaech, S.M. Effector CD8 T cell development: a balancing act between memory cell potential and terminal differentiation. (2008) Journal of Immunology. 180(3):1309-15.

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D'Souza, A.D., Parikh, N., Kaech, S.M., Shadel, G.S. Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation. (2007) Mitochondrion. 7(6):374-85. DOI: 10.1016/j.mito.2007.08.001

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Wu, H., Yuan, M., Kaech, S.M., Halloran, E. A statistical analysis of memory CD8 T cell differentiation: An application of a hierarchical state space model to a short time course microarray experiment (2007) Annals of Applied Statistics. 1(2):442-458. DOI: doi:10.1214/07-AOAS118

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Wherry, E.J., Ha, S.J., Kaech, S.M., Haining, W.N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J.N., Barber, D.L., Ahmed, R. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. (2007) Immunity. 27(4):670-84. DOI: 10.1016/j.immuni.2007.09.006

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Kaech, S.M., Wherry, E.J. Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. (2007) Immunity. 27(3):393-405. DOI: 10.1016/j.immuni.2007.08.007

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Joshi, N.S., Cui, W., Chandele, A., Lee, H.K., Urso, D.R., Hagman, J., Gapin, L., Kaech, S.M. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. (2007) Immunity. 27(2):281-95. DOI: 10.1016/j.immuni.2007.07.010

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Hand, T.W., Morre, M., Kaech, S.M. Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection. (2007) Proceedings of the National Academy of Sciences of the United States of America. 104(28):11730-5. DOI: 10.1073/pnas.0705007104

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Tesar, B.M., Walker, W.E., Unternaehrer, J., Joshi, N.S., Chandele, A., Haynes, L., Kaech, S., Goldstein, D.R. Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging. (2006) Aging Cell. 5(6):473-86. DOI: 10.1111/j.1474-9726.2006.00245.x

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Intlekofer, A.M., Takemoto, N., Wherry, E.J., Longworth, S.A., Northrup, J.T., Palanivel, V.R., Mullen, A.C., Gasink, C.R., Kaech, S.M., Miller, J.D., Gapin, L., Ryan, K., Russ, A.P., Lindsten, T., Orange, J.S., Goldrath, A.W., Ahmed, R., Reiner, S.L. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. (2005) Nature Immunology. 6(12):1236-44. DOI: 10.1038/ni1268

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Gao, Y., Tao, J., Li, M.O., Zhang, D., Chi, H., Henegariu, O., Kaech, S.M., Davis, R.J., Flavell, R.A., Yin, Z. JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. (2005) Journal of immunology. 175(9):5783-9.

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Chandele, A., Kaech, S.M. Cutting edge: memory CD8 T cell maturation occurs independently of CD8alphaalpha. (2005) Journal of immunology. 175(9):5619-23.

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Manders, P.M., Hunter, P.J., Telaranta, A.I., Carr, J.M., Marshall, J.L., Carrasco, M., Murakami, Y., Palmowski, M.J., Cerundolo, V., Kaech, S.M., Ahmed, R., Fearon, D.T. BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes. (2005) Proceedings of the National Academy of Sciences of the United States of America. 102(21):7418-25. DOI: 10.1073/pnas.0501585102

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Paiardini, M., Cervasi, B., Albrecht, H., Muthukumar, A., Dunham, R., Gordon, S., Radziewicz, H., Piedimonte, G., Magnani, M., Montroni, M., Kaech, S.M., Weintrob, A., Altman, J.D., Sodora, D.L., Feinberg, M.B., Silvestri, G. Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals. (2005) Journal of immunology. 174(5):2900-9.

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Wherry, E.J., Barber, D.L., Kaech, S.M., Blattman, J.N., Ahmed, R. Antigen-independent memory CD8 T cells do not develop during chronic viral infection. (2004) Proceedings of the National Academy of Sciences of the United States of America. 101(45):16004-9. DOI: 10.1073/pnas.0407192101

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Sabbagh, L., Kaech, S.M., Bourbonnière, M., Woo, M., Cohen, L.Y., Haddad, E.K., Labrecque, N., Ahmed, R., Sékaly, R.P. The selective increase in caspase-3 expression in effector but not memory T cells allows susceptibility to apoptosis. (2004) Journal of immunology. 173(9):5425-33.

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Latner, D.R., Kaech, S.M., Ahmed, R. Enhanced expression of cell cycle regulatory genes in virus-specific memory CD8+ T cells. (2004) Journal of Virology. 78(20):10953-9. DOI: 10.1128/JVI.78.20.10953-10959.2004

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Masopust, D., Kaech, S.M., Wherry, E.J., Ahmed, R. The role of programming in memory T-cell development. (2004) Current Opinion in Immunology. 16(2):217-25. DOI: 10.1016/j.coi.2004.02.005

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Kaech, S.M., Tan, J.T., Wherry, E.J., Konieczny, B.T., Surh, C.D., Ahmed, R. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. (2003) Nature Immunology. 4(12):1191-8. DOI: 10.1038/ni1009

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Wan, J., Martinvalet, D., Ji, X., Lois, C., Kaech, S.M., Von Andrian, U.H., Lieberman, J., Ahmed, R., Manjunath, N. The Bcl-2 family pro-apoptotic molecule, BNIP3 regulates activation-induced cell death of effector cytotoxic T lymphocytes. (2003) Immunology. 110(1):10-7.

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Adams, A.B., Williams, M.A., Jones, T.R., Shirasugi, N., Durham, M.M., Kaech, S.M., Wherry, E.J., Onami, T., Lanier, J.G., Kokko, K.E., Pearson, T.C., Ahmed, R., Larsen, C.P. Heterologous immunity provides a potent barrier to transplantation tolerance. (2003) Journal of Clinical Investigation. 111(12):1887-95. DOI: 10.1172/JCI17477

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Kersh, E.N., Kaech, S.M., Onami, T.M., Moran, M., Wherry, E.J., Miceli, M.C., Ahmed, R. TCR signal transduction in antigen-specific memory CD8 T cells. (2003) Journal of Immunology. 170(11):5455-63.

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Blattman, J.N., Grayson, J.M., Wherry, E.J., Kaech, S.M., Smith, K.A., Ahmed, R. Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. (2003) Nature Medicine. 9(5):540-7. DOI: 10.1038/nm866

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Antia, R., Bergstrom, C.T., Pilyugin, S.S., Kaech, S.M., Ahmed, R. Models of CD8+ responses: 1. What is the antigen-independent proliferation program. (2003) Journal of Theoretical Biology. 221(4):585-98.

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Kaech, S.M., Ahmed, R. Immunology. CD8 T cells remember with a little help. (2003) Science. 300(5617):263-5. DOI: 10.1126/science.1084511


Wherry, E.J., Teichgräber, V., Becker, T.C., Masopust, D., Kaech, S.M., Antia, R., von Andrian, U.H., Ahmed, R. Lineage relationship and protective immunity of memory CD8 T cell subsets. (2003) Nature Immunology. 4(3):225-34. DOI: 10.1038/ni889

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Shen, H., Whitmire, J.K., Fan, X., Shedlock, D.J., Kaech, S.M., Ahmed, R. A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes. (2003) Journal of immunology. 170(3):1443-51.

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Hathcock, K.S., Kaech, S.M., Ahmed, R., Hodes, R.J. Induction of telomerase activity and maintenance of telomere length in virus-specific effector and memory CD8+ T cells. (2003) Journal of Immunology. 170(1):147-52.

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Kaech, S.M., Hemby, S., Kersh, E., Ahmed, R. Molecular and functional profiling of memory CD8 T cell differentiation. (2002) Cell. 111(6):837-51.

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Kaech, S.M., Wherry, E.J., Ahmed, R. Effector and memory T-cell differentiation: implications for vaccine development. (2002) Nature Reviews. Immunology. 2(4):251-62. DOI: 10.1038/nri778

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Kaech, S.M., Ahmed, R. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells. (2001) Nature Immunology. 2(5):415-22. DOI: 10.1038/87720

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Perego, C., Vanoni, C., Villa, A., Longhi, R., Kaech, S.M., Fröhli, E., Hajnal, A., Kim, S.K., Pietrini, G. PDZ-mediated interactions retain the epithelial GABA transporter on the basolateral surface of polarized epithelial cells. (1999) EMBO Journal. 18(9):2384-93. DOI: 10.1093/emboj/18.9.2384

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Borg, J.P., Straight, S.W., Kaech, S.M., de Taddéo-Borg, M., Kroon, D.E., Karnak, D., Turner, R.S., Kim, S.K., Margolis, B. Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. (1998) Journal of Biological Chemistry. 273(48):31633-6.

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Kaech, S.M., Whitfield, C.W., Kim, S.K. The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. (1998) Cell. 94(6):761-71.

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Simske, J.S., Kaech, S.M., Harp, S.A., Kim, S.K. LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction. (1996) Cell. 85(2):195-204. DOI: 0.1016/s0092-8674(00)81096-x

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Education

BS, Cellular and Molecular Biology, University of Washington
PhD, Developmental Biology, Stanford University


Awards & Honors

  • 2009 Howard Hughes Early Career Scientist
  • 2007 Presidential Early Career Award for Scientists and Engineers (PECASE)
  • 2007 American Asthma Foundation Investigator
  • 2005 Cancer Research Institute Investigator Award
  • 2005 Edward Mallinckrodt Jr. Foundation Award
  • 2003 Burroughs Wellcome Fund Career Award in the Biosciences
  • 1999 Damon Runyon-Walter Winchell Cancer Research Fellowship
  • 1993 National Science Foundation Predoctoral Fellowship