Pallav Kosuri, PhD

Assistant Professor

Integrative Biology Laboratory

Hearst Foundation Developmental Chair

Pallav Kosuri
Salk Institute for Biological Studies - Publications

all Publications


Lee, H., Yu, C.C., Boyden, E.S., Zhuang, X., Kosuri, P. Tetra-gel enables superior accuracy in combined super-resolution imaging and expansion microscopy. (2021) Scientific Reports. 11(1):16944. DOI: 10.1038/s41598-021-96258-y

+ expand abstract


Kosuri, P., Altheimer, B.D., Dai, M., Yin, P., Zhuang, X. Rotation tracking of genome-processing enzymes using DNA origami rotors. (2019) Nature. 572(7767):136-140. DOI: 10.1038/s41586-019-1397-7

+ expand abstract


Rivas-Pardo, J.A., Eckels, E.C., Popa, I., Kosuri, P., Linke, W.A., Fernández, J.M. Work Done by Titin Protein Folding Assists Muscle Contraction. (2016) Cell Reports. 14(6):1339-1347. DOI: 10.1016/j.celrep.2016.01.025

+ expand abstract


Inouye, S., Bouras, V., Shouldis, E., Johnstone, A., Silverzweig, Z., Kosuri, P. Predicting readmission of heart failure patients using automated follow-up calls. (2015) BMC Med Inform Decis Mak. 15:22. DOI: 10.1186/s12911-015-0144-8

+ expand abstract


Lee, L., Kosuri, P., Arancio, O. Picomolar amyloid-β peptides enhance spontaneous astrocyte calcium transients. (2013) J Alzheimers Dis. 38(1):49-62. DOI: 10.3233/JAD-130740

+ expand abstract


Popa, I., Kosuri, P., Alegre-Cebollada, J., Garcia-Manyes, S., Fernandez, J.M. Force dependency of biochemical reactions measured by single-molecule force-clamp spectroscopy. (2013) Nature Protocols. 8(7):1261-76. DOI: 10.1038/nprot.2013.056

+ expand abstract


Kosuri, P., Alegre-Cebollada, J., Feng, J., Kaplan, A., Inglés-Prieto, A., Badilla, C.L., Stockwell, B.R., Sanchez-Ruiz, J.M., Holmgren, A., Fernández, J.M. Protein folding drives disulfide formation. (2012) Cell. 151(4):794-806. DOI: 10.1016/j.cell.2012.09.036

+ expand abstract


Alegre-Cebollada, J., Kosuri, P., Rivas-Pardo, J.A., Fernández, J.M. Direct observation of disulfide isomerization in a single protein. (2011) Nature Chemistry. 3(11):882-7. DOI: 10.1038/nchem.1155

+ expand abstract


Perez-Jimenez, R., Inglés-Prieto, A., Zhao, Z.M., Sanchez-Romero, I., Alegre-Cebollada, J., Kosuri, P., Garcia-Manyes, S., Kappock, T.J., Tanokura, M., Holmgren, A., Sanchez-Ruiz, J.M., Gaucher, E.A., Fernandez, J.M. Single-molecule paleoenzymology probes the chemistry of resurrected enzymes. (2011) Nature Structural & Molecular Biology. 18(5):592-6. DOI: 10.1038/nsmb.2020

+ expand abstract


Alegre-Cebollada, J., Kosuri, P., Fernández, J.M. Protease power strokes force proteins to unfold. (2011) Cell. 145(3):339-40. DOI: 10.1016/j.cell.2011.04.007

+ expand abstract


Alegre-Cebollada, J., Perez-Jimenez, R., Kosuri, P., Fernandez, J.M. Single-molecule force spectroscopy approach to enzyme catalysis. (2010) Journal of Biological Chemistry. 285(25):18961-6. DOI: 10.1074/jbc.R109.011932

+ expand abstract


Fernandez, V.I., Kosuri, P., Parot, V., Fernandez, J.M. Extended Kalman filter estimates the contour length of a protein in single molecule atomic force microscopy experiments. (2009) Rev Sci Instrum. 80(11):113104. DOI: 10.1063/1.3252982

+ expand abstract


O'Connell, N.E., Grey, M.J., Tang, Y., Kosuri, P., Miloushev, V.Z., Raleigh, D.P., Palmer, A.G. Partially folded equilibrium intermediate of the villin headpiece HP67 defined by 13C relaxation dispersion. (2009) J Biomol NMR. 45(1-2):85-98. DOI: 10.1007/s10858-009-9340-0

+ expand abstract


Perez-Jimenez, R., Li, J., Kosuri, P., Sanchez-Romero, I., Wiita, A.P., Rodriguez-Larrea, D., Chueca, A., Holmgren, A., Miranda-Vizuete, A., Becker, K., Cho, S.H., Beckwith, J., Gelhaye, E., Jacquot, J.P., Gaucher, E.A., Gaucher, E., Sanchez-Ruiz, J.M., Berne, B.J., Fernandez, J.M. Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. (2009) Nature Structural & Molecular Biology. 16(8):890-6. DOI: 10.1038/nsmb.1627

+ expand abstract


Perez-Jimenez, R., Wiita, A.P., Rodriguez-Larrea, D., Kosuri, P., Gavira, J.A., Sanchez-Ruiz, J.M., Fernandez, J.M. Force-clamp spectroscopy detects residue co-evolution in enzyme catalysis. (2008) Journal of Biological Chemistry. 283(40):27121-9. DOI: 10.1074/jbc.M803746200

+ expand abstract


Fei, J., Kosuri, P., MacDougall, D.D., Gonzalez, R.L. Coupling of ribosomal L1 stalk and tRNA dynamics during translation elongation. (2008) Molecular Cell. 30(3):348-59. DOI: 10.1016/j.molcel.2008.03.012

+ expand abstract


Education

Postdoctoral Fellow, Harvard University
PhD, Biochemistry and Molecular Biophysics, Columbia University
MSc, Engineering Physics, KTH Royal Institute of Technology


Awards & Honors

  • W.M. Keck Foundation Award, 2024
  • Beckman Young Investigator Award, 2022
  • Titus M. Coan Prize for Excellence in Basic Research
  • The Columbia University Distinction Award for Doctoral Defense
  • Fulbright Scholarship

Profile