Pallav Kosuri

Assistant Professor

Integrative Biology Laboratory

Pallav Kosuri
Salk Institute for Biological Studies - Publications

Publications


Rotation tracking of genome-processing enzymes using DNA origami rotors.
Kosuri P, Altheimer BD, Dai M, Yin P, Zhuang X.
Nature. 2019 Aug;572(7767):136-140. doi: 10.1038/s41586-019-1397-7. Epub 2019 Jul 17.
PMID: 31316204

Work Done by Titin Protein Folding Assists Muscle Contraction.
Rivas-Pardo JA, Eckels EC, Popa I, Kosuri P, Linke WA, Fernández JM.
Cell Rep. 2016 Feb 16;14(6):1339-1347. doi: 10.1016/j.celrep.2016.01.025. Epub 2016 Feb 4.
PMID: 26854230

Predicting readmission of heart failure patients using automated follow-up calls.
Inouye S, Bouras V, Shouldis E, Johnstone A, Silverzweig Z, Kosuri P.
BMC Med Inform Decis Mak. 2015 Mar 29;15:22. doi: 10.1186/s12911-015-0144-8.
PMID: 25890356

S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding.
Alegre-Cebollada J, Kosuri P, Giganti D, Eckels E, Rivas-Pardo JA, Hamdani N, Warren CM, Solaro RJ, Linke WA, Fernández JM.
Cell. 2014 Mar 13;156(6):1235-1246. doi: 10.1016/j.cell.2014.01.056.
PMID: 24630725

Picomolar amyloid-β peptides enhance spontaneous astrocyte calcium transients.
Lee L, Kosuri P, Arancio O.
J Alzheimers Dis. 2014;38(1):49-62. doi: 10.3233/JAD-130740.
PMID: 23948929

Force dependency of biochemical reactions measured by single-molecule force-clamp spectroscopy.
Popa I, Kosuri P, Alegre-Cebollada J, Garcia-Manyes S, Fernandez JM.
Nat Protoc. 2013;8(7):1261-76. doi: 10.1038/nprot.2013.056. Epub 2013 Jun 6.
PMID: 23744288

Protein folding drives disulfide formation.
Kosuri P, Alegre-Cebollada J, Feng J, Kaplan A, Inglés-Prieto A, Badilla CL, Stockwell BR, Sanchez-Ruiz JM, Holmgren A, Fernández JM.
Cell. 2012 Nov 9;151(4):794-806. doi: 10.1016/j.cell.2012.09.036.
PMID: 23141538

Direct observation of disulfide isomerization in a single protein.
Alegre-Cebollada J, Kosuri P, Rivas-Pardo JA, Fernández JM.
Nat Chem. 2011 Oct 9;3(11):882-7. doi: 10.1038/nchem.1155.
PMID: 22024885

Protease power strokes force proteins to unfold.
Alegre-Cebollada J, Kosuri P, Fernández JM.
Cell. 2011 Apr 29;145(3):339-40. doi: 10.1016/j.cell.2011.04.007.
PMID: 21529709

Single-molecule paleoenzymology probes the chemistry of resurrected enzymes.
Perez-Jimenez R, Inglés-Prieto A, Zhao ZM, Sanchez-Romero I, Alegre-Cebollada J, Kosuri P, Garcia-Manyes S, Kappock TJ, Tanokura M, Holmgren A, Sanchez-Ruiz JM, Gaucher EA, Fernandez JM.
Nat Struct Mol Biol. 2011 May;18(5):592-6. doi: 10.1038/nsmb.2020. Epub 2011 Apr 3.
PMID: 21460845

Single-molecule force spectroscopy approach to enzyme catalysis.
Alegre-Cebollada J, Perez-Jimenez R, Kosuri P, Fernandez JM.
J Biol Chem. 2010 Jun 18;285(25):18961-6. doi: 10.1074/jbc.R109.011932. Epub 2010 Apr 9.
PMID: 20382731 Review.

Extended Kalman filter estimates the contour length of a protein in single molecule atomic force microscopy experiments.
Fernandez VI, Kosuri P, Parot V, Fernandez JM.
Rev Sci Instrum. 2009 Nov;80(11):113104. doi: 10.1063/1.3252982.
PMID: 19947714

Partially folded equilibrium intermediate of the villin headpiece HP67 defined by 13C relaxation dispersion.
O’Connell NE, Grey MJ, Tang Y, Kosuri P, Miloushev VZ, Raleigh DP, Palmer AG 3rd.
J Biomol NMR. 2009 Sep;45(1-2):85-98. doi: 10.1007/s10858-009-9340-0. Epub 2009 Jul 31.
PMID: 19644656

Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy.
Perez-Jimenez R, Li J, Kosuri P, Sanchez-Romero I, Wiita AP, Rodriguez-Larrea D, Chueca A, Holmgren A, Miranda-Vizuete A, Becker K, Cho SH, Beckwith J, Gelhaye E, Jacquot JP, Gaucher EA, Sanchez-Ruiz JM, Berne BJ, Fernandez JM.
Nat Struct Mol Biol. 2009 Aug;16(8):890-6. doi: 10.1038/nsmb.1627. Epub 2009 Jul 13.
PMID: 19597482

Force-clamp spectroscopy detects residue co-evolution in enzyme catalysis.
Perez-Jimenez R, Wiita AP, Rodriguez-Larrea D, Kosuri P, Gavira JA, Sanchez-Ruiz JM, Fernandez JM.
J Biol Chem. 2008 Oct 3;283(40):27121-9. doi: 10.1074/jbc.M803746200. Epub 2008 Aug 7.
PMID: 18687682

Coupling of ribosomal L1 stalk and tRNA dynamics during translation elongation.
Fei J, Kosuri P, MacDougall DD, Gonzalez RL Jr.
Mol Cell. 2008 May 9;30(3):348-59. doi: 10.1016/j.molcel.2008.03.012.
PMID: 18471980

Education

Postdoctoral Fellow, Harvard University
PhD, Biochemistry and Molecular Biophysics, Columbia University
MSc, Engineering Physics, KTH Royal Institute of Technology


Awards & Honors

  • Titus M. Coan Prize for Excellence in Basic Research
  • The Columbia University Distinction Award for Doctoral Defense
  • Fulbright Scholarship