Kuo-Fen Lee

Professor

Clayton Foundation Laboratories for Peptide Biology

Helen McLoraine Chair in Molecular Neurobiology

Salk Institute for Biological Studies - Publications

all Publications


Liu, Y., Sugiura, Y., Chen, F., Lee, K.F., Ye, Q., Lin, W. Blocking skeletal muscle DHPRs/Ryr1 prevents neuromuscular synapse loss in mutant mice deficient in type III Neuregulin 1 (CRD-Nrg1). (2019) PLOS Genetics. 15(3):e1007857. DOI: 10.1371/journal.pgen.1007857

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Gould, T.W., Dominguez, B., de Winter, F., Yeo, G.W., Liu, P., Sundararaman, B., Stark, T., Vu, A., Degen, J.L., Lin, W., Lee, K.F. Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal. (2019) PLOS Genetics. 15(3):e1007948. DOI: 10.1371/journal.pgen.1007948

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Yoon, Y.S., Tsai, W.W., Van de Velde, S., Chen, Z., Lee, K.F., Morgan, D.A., Rahmouni, K., Matsumura, S., Wiater, E., Song, Y., Montminy, M. cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis. (2018) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1805257115

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Chen, Z., Donnelly, C.R., Dominguez, B., Harada, Y., Lin, W., Halim, A.S., Bengoechea, T.G., Pierchala, B.A., Lee, K.F. p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling. (2017) Cell Reports. 21(3):707-720. DOI: 10.1016/j.celrep.2017.09.037

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Hirai, M., Arita, Y., McGlade, C.J., Lee, K.F., Chen, J., Evans, S.M. Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. (2017) Journal of Clinical Investigation. 127(2):569-582. DOI: 10.1172/JCI91081

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Chu, Q., Diedrich, J.K., Vaughan, J.M., Donaldson, C.J., Nunn, M.F., Lee, K.F., Saghatelian, A. HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective. (2016) Journal of the American Chemical Society. 138(30):9473-8. DOI: 10.1021/jacs.6b03463

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Mo, A.H., Landon, P.B., Gomez, K.S., Kang, H., Lee, J., Zhang, C., Janetanakit, W., Sant, V., Lu, T., Colburn, D.A., Akkiraju, S., Dossou, S., Cao, Y., Lee, K.F., Varghese, S., Glinsky, G., Lal, R. Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing. (2016) Nanoscale. 8(23):11840-50. DOI: 10.1039/c6nr02445a

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Amin, N.D., Bai, G., Klug, J.R., Bonanomi, D., Pankratz, M.T., Gifford, W.D., Hinckley, C.A., Sternfeld, M.J., Driscoll, S.P., Dominguez, B., Lee, K.F., Jin, X., Pfaff, S.L. Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure. (2015) Science. 350(6267):1525-9. DOI: 10.1126/science.aad2509

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Izpisua Belmonte, J.C., Callaway, E.M., Caddick, S.J., Churchland, P., Feng, G., Homanics, G.E., Lee, K.F., Leopold, D.A., Miller, C.T., Mitchell, J.F., Mitalipov, S., Moutri, A.R., Movshon, J.A., Okano, H., Reynolds, J.H., Ringach, D., Sejnowski, T.J., Silva, A.C., Strick, P.L., Wu, J., Zhang, F. Brains, genes, and primates. (2015) Neuron. 86(3):617-31. DOI: 10.1016/j.neuron.2015.03.021

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Vilar, M., Sung, T.C., Chen, Z., García-Carpio, I., Fernandez, E.M., Xu, J., Riek, R., Lee, K.F. Heterodimerization of p45-p75 modulates p75 signaling: structural basis and mechanism of action. (2014) PLOS Biology. 12(8):e1001918. DOI: 10.1371/journal.pbio.1001918

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Large, M.J., Wetendorf, M., Lanz, R.B., Hartig, S.M., Creighton, C.J., Mancini, M.A., Kovanci, E., Lee, K.F., Threadgill, D.W., Lydon, J.P., Jeong, J.W., DeMayo, F.J. The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. (2014) PLOS Genetics. 10(6):e1004451. DOI: 10.1371/journal.pgen.1004451

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Sung, T.C., Chen, Z., Thuret, S., Vilar, M., Gage, F.H., Riek, R., Lee, K.F. P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury. (2013) PLOS One. 8(7):e69286. DOI: 10.1371/journal.pone.0069286

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Seidel, S., Bruce, J., Leblanc, M., Lee, K.F., Fan, H., Ahlquist, P., Young, J.A. ZASC1 knockout mice exhibit an early bone marrow-specific defect in murine leukemia virus replication. (2013) Virology Journal. 10:130. DOI: 10.1186/1743-422X-10-130

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Wei, P.C., Hsieh, Y.H., Su, M.I., Jiang, X., Hsu, P.H., Lo, W.T., Weng, J.Y., Jeng, Y.M., Wang, J.M., Chen, P.L., Chang, Y.C., Lee, K.F., Tsai, M.D., Shew, J.Y., Lee, W.H. Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease. (2012) Molecular Cell. 48(5):747-59. DOI: 10.1016/j.molcel.2012.10.007

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Morello, C.S., Kraynyak, K.A., Levinson, M.S., Chen, Z., Lee, K.F., Spector, D.H. Inactivated HSV-2 in MPL/alum adjuvant provides nearly complete protection against genital infection and shedding following long term challenge and rechallenge. (2012) Vaccine. 30(46):6541-6550. DOI: 10.1016/j.vaccine.2012.08.049

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Montminy, M., Lee, K.F., Rivier, J.E., Rivier, C., Reichlin, S. Wylie Vale: neuroendocrine master. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(10):3604-5. DOI: 10.1073/pnas.1201696109


Yang, J., Dominguez, B., de Winter, F., Gould, T.W., Eriksson, J.E., Lee, K.F. Nestin negatively regulates postsynaptic differentiation of the neuromuscular synapse. (2011) Nature Neuroscience. 14(3):324-30. DOI: 10.1038/nn.2747

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An, M.C., Lin, W., Yang, J., Dominguez, B., Padgett, D., Sugiura, Y., Aryal, P., Gould, T.W., Oppenheim, R.W., Hester, M.E., Kaspar, B.K., Ko, C.P., Lee, K.F. Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(23):10702-7. DOI: 10.1073/pnas.1004956107

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Bengoechea, T.G., Chen, Z., O'Leary, D.A., O'Leary, D., Masliah, E., Lee, K.F. p75 reduces beta-amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model. (2009) Proceedings of the National Academy of Sciences of the United States of America. 106(19):7870-5. DOI: 10.1073/pnas.0901533106

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Lim, Y.S., McLaughlin, T., Sung, T.C., Santiago, A., Lee, K.F., O'Leary, D.D. p75(NTR) mediates ephrin-A reverse signaling required for axon repulsion and mapping. (2008) Neuron. 59(5):746-58. DOI: 10.1016/j.neuron.2008.07.032

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Wang, W., Takimoto, J.K., Louie, G.V., Baiga, T.J., Noel, J.P., Lee, K.F., Slesinger, P.A., Wang, L. Genetically encoding unnatural amino acids for cellular and neuronal studies. (2007) Nature Neuroscience. 10(8):1063-72. DOI: 10.1038/nn1932

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Rissman, R.A., Lee, K.F., Vale, W., Sawchenko, P.E. Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation. (2007) Journal of Neuroscience. 27(24):6552-62. DOI: 10.1523/JNEUROSCI.5173-06.2007

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Li, C., Chen, P., Vaughan, J., Lee, K.F., Vale, W. Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis. (2007) Proceedings of the National Academy of Sciences of the United States of America. 104(10):4206-11. DOI: 10.1073/pnas.0611641104

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Chen, A., Brar, B., Choi, C.S., Rousso, D., Vaughan, J., Kuperman, Y., Kim, S.N., Donaldson, C., Smith, S.M., Jamieson, P., Li, C., Nagy, T.R., Shulman, G.I., Lee, K.F., Vale, W. Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(44):16580-5. DOI: 10.1073/pnas.0607337103

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Negro, A., Brar, B.K., Gu, Y., Peterson, K.L., Vale, W., Lee, K.F. erbB2 is required for G protein-coupled receptor signaling in the heart. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(43):15889-93. DOI: 10.1073/pnas.0607499103

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Chen, A., Zorrilla, E., Smith, S., Rousso, D., Levy, C., Vaughan, J., Donaldson, C., Roberts, A., Lee, K.F., Vale, W. Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior. (2006) Journal of Neuroscience. 26(20):5500-10. DOI: 10.1523/JNEUROSCI.3955-05.2006

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Morris, J.K., Maklad, A., Hansen, L.A., Feng, F., Sorensen, C., Lee, K.F., Macklin, W.B., Fritzsch, B. A disorganized innervation of the inner ear persists in the absence of ErbB2. (2006) Brain Research. 1091(1):186-99. DOI: 10.1016/j.brainres.2006.02.090

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Lin, W., Dominguez, B., Yang, J., Aryal, P., Brandon, E.P., Gage, F.H., Lee, K.F. Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism. (2005) Neuron. 46(4):569-79. DOI: 10.1016/j.neuron.2005.04.002

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Myers, C.P., Lewcock, J.W., Hanson, M.G., Gosgnach, S., Aimone, J.B., Gage, F.H., Lee, K.F., Landmesser, L.T., Pfaff, S.L. Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. (2005) Neuron. 46(1):37-49. DOI: 10.1016/j.neuron.2005.02.022

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Wang, P., Yang, G., Mosier, D.R., Chang, P., Zaidi, T., Gong, Y.D., Zhao, N.M., Dominguez, B., Lee, K.F., Gan, W.B., Zheng, H. Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. (2005) Journal of Neuroscience. 25(5):1219-25. DOI: 10.1523/JNEUROSCI.4660-04.2005

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Jackson-Fisher, A.J., Bellinger, G., Ramabhadran, R., Morris, J.K., Lee, K.F., Stern, D.F. ErbB2 is required for ductal morphogenesis of the mammary gland. (2004) Proceedings of the National Academy of Sciences of the United States of America. 101(49):17138-43. DOI: 10.1073/pnas.0407057101

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Joseph, N.M., Mukouyama, Y.S., Mosher, J.T., Jaegle, M., Crone, S.A., Dormand, E.L., Lee, K.F., Meijer, D., Anderson, D.J., Morrison, S.J. Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells. (2004) Development. 131(22):5599-612. DOI: 10.1242/dev.01429

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Negro, A., Brar, B.K., Lee, K.F. Essential roles of Her2/erbB2 in cardiac development and function. (2004) Recent progress in Hormone Research. 59:1-12.

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Lin, S.C., Lee, K.F., Nikitin, A.Y., Hilsenbeck, S.G., Cardiff, R.D., Li, A., Kang, K.W., Frank, S.A., Lee, W.H., Lee, E.Y. Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis. (2004) Cancer Research. 64(10):3525-32. DOI: 10.1158/0008-5472.CAN-03-3524

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Bale, T.L., Hoshijima, M., Gu, Y., Dalton, N., Anderson, K.R., Lee, K.F., Rivier, J., Chien, K.R., Vale, W.W., Peterson, K.L. The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure. (2004) Proceedings of the National Academy of Sciences of the United States of America. 101(10):3697-702. DOI: 10.1073/pnas.0307324101

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Brar, B.K., Jonassen, A.K., Egorina, E.M., Chen, A., Negro, A., Perrin, M.H., Mjøs, O.D., Latchman, D.S., Lee, K.F., Vale, W. Urocortin-II and urocortin-III are cardioprotective against ischemia reperfusion injury: an essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine (2004) Endocrinology. 145(1):24-35; discussion 21-3. DOI: 10.1210/en.2003-0689

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Lee, C.H., Chawla, A., Urbiztondo, N., Liao, D., Boisvert, W.A., Evans, R.M., Curtiss, L.K. Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. (2003) Science. 302(5644):453-7. DOI: 10.1126/science.1087344

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Bale, T.L., Anderson, K.R., Roberts, A.J., Lee, K.F., Nagy, T.R., Vale, W.W. Corticotropin-releasing factor receptor-2-deficient mice display abnormal homeostatic responses to challenges of increased dietary fat and cold. (2003) Endocrinology. 144(6):2580-7. DOI: 10.1210/en.2002-0091

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Zhao, X., Ueba, T., Christie, B.R., Barkho, B., McConnell, M.J., Nakashima, K., Lein, E.S., Eadie, B.D., Willhoite, A.R., Muotri, A.R., Summers, R.G., Chun, J., Lee, K.F., Gage, F.H. Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. (2003) Proceedings of the National Academy of Sciences of the United States of America. 100(11):6777-82. DOI: 10.1073/pnas.1131928100

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Brandon, E.P., Lin, W., D'Amour, K.A., Pizzo, D.P., Dominguez, B., Sugiura, Y., Thode, S., Ko, C.P., Thal, L.J., Gage, F.H., Lee, K.F. Aberrant patterning of neuromuscular synapses in choline acetyltransferase-deficient mice. (2003) Journal of Neuroscience. 23(2):539-49.

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Crone, S.A., Negro, A., Trumpp, A., Giovannini, M., Lee, K.F. Colonic epithelial expression of ErbB2 is required for postnatal maintenance of the enteric nervous system. (2003) Neuron. 37(1):29-40.

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Crone, S.A., Lee, K.F. The bound leading the bound: target-derived receptors act as guidance cues. (2002) Neuron. 36(3):333-5.

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Crone, S.A., Lee, K.F. Gene targeting reveals multiple essential functions of the neuregulin signaling system during development of the neuroendocrine and nervous systems. (2002) Ann. N. Y. Acad. Sci. 971:547-53.

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Vetter, D.E., Li, C., Zhao, L., Contarino, A., Liberman, M.C., Smith, G.W., Marchuk, Y., Koob, G.F., Heinemann, S.F., Vale, W., Lee, K.F. Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior. (2002) Nature Genetics. 31(4):363-9. DOI: 10.1038/ng914

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Bale, T.L., Lee, K.F., Vale, W.W. The role of corticotropin-releasing factor receptors in stress and anxiety. (2002) Integrative and Comparative Biology. 42(3):552-5. DOI: 10.1093/icb/42.3.552

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Bale, T.L., Giordano, F.J., Hickey, R.P., Huang, Y., Nath, A.K., Peterson, K.L., Vale, W.W., Lee, K.F. Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization. (2002) Proceedings of the National Academy of Sciences of the United States of America. 99(11):7734-9. DOI: 10.1073/pnas.102187099

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Crone, S.A., Zhao, Y.Y., Fan, L., Gu, Y., Minamisawa, S., Liu, Y., Peterson, K.L., Chen, J., Kahn, R., Condorelli, G., Ross, J., Chien, K.R., Lee, K.F. ErbB2 is essential in the prevention of dilated cardiomyopathy. (2002) Nature Medicine. 8(5):459-65. DOI: 10.1038/nm0502-459

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Kaspar, B.K., Vissel, B., Bengoechea, T., Crone, S., Randolph-Moore, L., Muller, R., Brandon, E.P., Schaffer, D., Verma, I.M., Lee, K.F., Heinemann, S.F., Gage, F.H. Adeno-associated virus effectively mediates conditional gene modification in the brain. (2002) Proceedings of the National Academy of Sciences of the United States of America. 99(4):2320-5. DOI: 10.1073/pnas.042678699

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Bale, T.L., Picetti, R., Contarino, A., Koob, G.F., Vale, W.W., Lee, K.F. Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior. (2002) Journal of Neuroscience. 22(1):193-9.

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Lin, W., Burgess, R.W., Dominguez, B., Pfaff, S.L., Sanes, J.R., Lee, K.F. Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse. (2001) Nature. 410(6832):1057-64. DOI: 10.1038/35074025

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Lee, S., Smith, G.W., Vale, W., Lee, K.F., Rivier, C. Mice that lack corticotropin-releasing factor (CRF) receptors type 1 show a blunted ACTH response to acute alcohol despite up-regulated constitutive hypothalamic CRF gene expression. (2001) Alcohol. Clin. Exp. Res. 25(3):427-33.

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Bentley, C.A., Lee, K.F. p75 is important for axon growth and schwann cell migration during development. (2000) Journal of Neuroscience. 20(20):7706-15.

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Bradbury, M.J., McBurnie, M.I., Denton, D.A., Lee, K.F., Vale, W.W. Modulation of urocortin-induced hypophagia and weight loss by corticotropin-releasing factor receptor 1 deficiency in mice. (2000) Endocrinology. 141(8):2715-24. DOI: 10.1210/endo.141.8.7606

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Syroid, D.E., Maycox, P.J., Soilu-Hänninen, M., Petratos, S., Bucci, T., Burrola, P., Murray, S., Cheema, S., Lee, K.F., Lemke, G., Kilpatrick, T.J. Induction of postnatal schwann cell death by the low-affinity neurotrophin receptor in vitro and after axotomy. (2000) Journal of Neuroscience. 20(15):5741-7.

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Contarino, A., Dellu, F., Koob, G.F., Smith, G.W., Lee, K.F., Vale, W.W., Gold, L.H. Dissociation of locomotor activation and suppression of food intake induced by CRF in CRFR1-deficient mice. (2000) Endocrinology. 141(7):2698-702. DOI: 10.1210/endo.141.7.7653

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Bale, T.L., Contarino, A., Smith, G.W., Chan, R., Gold, L.H., Sawchenko, P.E., Koob, G.F., Vale, W.W., Lee, K.F. Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. (2000) Nature Genetics. 24(4):410-4. DOI: 10.1038/74263

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Lin, W., Sanchez, H.B., Deerinck, T., Morris, J.K., Ellisman, M., Lee, K.F. Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice. (2000) Proceedings of the National Academy of Sciences of the United States of America. 97(3):1299-304.

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Blume-Jensen, P., Jiang, G., Hyman, R., Lee, K.F., O'Gorman, S., Hunter, T. Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility. (2000) Nature Genetics. 24(2):157-62. DOI: 10.1038/72814

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Morris, J.K., Lin, W., Hauser, C., Marchuk, Y., Getman, D., Lee, K.F. Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development. (1999) Neuron. 23(2):273-83.

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Li, Q., Lu, Q., Hwang, J.Y., Büscher, D., Lee, K.F., Izpisua-Belmonte, J.C., Verma, I.M. IKK1-deficient mice exhibit abnormal development of skin and skeleton. (1999) Genes & Development. 13(10):1322-8.

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Li, Q., Van Antwerp, D., Mercurio, F., Lee, K.F., Verma, I.M. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. (1999) Science. 284(5412):321-5.

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Turnbull, A.V., Smith, G.W., Lee, S., Vale, W.W., Lee, K.F., Rivier, C. CRF type I receptor-deficient mice exhibit a pronounced pituitary-adrenal response to local inflammation. (1999) Endocrinology. 140(2):1013-7. DOI: 10.1210/endo.140.2.6675

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Peterson, D.A., Dickinson-Anson, H.A., Leppert, J.T., Lee, K.F., Gage, F.H. Central neuronal loss and behavioral impairment in mice lacking neurotrophin receptor p75. (1999) Journal of Comparative Neurology. 404(1):1-20.

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Smith, G.W., Aubry, J.M., Dellu, F., Contarino, A., Bilezikjian, L.M., Gold, L.H., Chen, R., Marchuk, Y., Hauser, C., Bentley, C.A., Sawchenko, P.E., Koob, G.F., Vale, W., Lee, K.F. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. (1998) Neuron. 20(6):1093-102.

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Wang, L., Zoppè, M., Hackeng, T.M., Griffin, J.H., Lee, K.F., Verma, I.M. A factor IX-deficient mouse model for hemophilia B gene therapy. (1997) Proceedings of the National Academy of Sciences of the United States of America. 94(21):11563-6.

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Anton, E.S., Marchionni, M.A., Lee, K.F., Rakic, P. Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex. (1997) Development. 124(18):3501-10.

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Sarram, S., Lee, K.F., Byers, M.R. Dental innervation and CGRP in adult p75-deficient mice. (1997) Journal of Comparative Neurology. 385(2):297-308.

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Syroid, D.E., Maycox, P.R., Burrola, P.G., Liu, N., Wen, D., Lee, K.F., Lemke, G., Kilpatrick, T.J. Cell death in the Schwann cell lineage and its regulation by neuregulin. (1996) Proceedings of the National Academy of Sciences of the United States of America. 93(17):9229-34.

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ElShamy, W.M., Linnarsson, S., Lee, K.F., Jaenisch, R., Ernfors, P. Prenatal and postnatal requirements of NT-3 for sympathetic neuroblast survival and innervation of specific targets. (1996) Development. 122(2):491-500.

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Lee, K.F., Simon, H., Chen, H., Bates, B., Hung, M.C., Hauser, C. Requirement for neuregulin receptor erbB2 in neural and cardiac development. (1995) Nature. 378(6555):394-8. DOI: 10.1038/378394a0

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Ernfors, P., Kucera, J., Lee, K.F., Loring, J., Jaenisch, R. Studies on the physiological role of brain-derived neurotrophic factor and neurotrophin-3 in knockout mice. (1995) International Journal of Developmental Biology. 39(5):799-807.

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Curtis, R., Adryan, K.M., Stark, J.L., Park, J.S., Compton, D.L., Weskamp, G., Huber, L.J., Chao, M.V., Jaenisch, R., Lee, K.F. Differential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins. (1995) Neuron. 14(6):1201-11.

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Ernfors, P., Lee, K.F., Kucera, J., Jaenisch, R. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. (1994) Cell. 77(4):503-12.

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Lee, K.F., Davies, A.M., Jaenisch, R. p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF. (1994) Development. 120(4):1027-33.

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Lee, K.F., Bachman, K., Landis, S., Jaenisch, R. Dependence on p75 for innervation of some sympathetic targets. (1994) Science. 263(5152):1447-9.

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Ernfors, P., Lee, K.F., Jaenisch, R. Mice lacking brain-derived neurotrophic factor develop with sensory deficits. (1994) Nature. 368(6467):147-50. DOI: 10.1038/368147a0

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Vassalli, A., Matzuk, M.M., Gardner, H.A., Lee, K.F., Jaenisch, R. Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction. (1994) Genes & Development. 8(4):414-27.

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Ernfors, P., Lee, K.F., Jaenisch, R. Target derived and putative local actions of neurotrophins in the peripheral nervous system. (1994) Progress in Brain Research. 103:43-54.


Davies, A.M., Lee, K.F., Jaenisch, R. p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins. (1993) Neuron. 11(4):565-74.

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Lee, K.F., Li, E., Huber, L.J., Landis, S.C., Sharpe, A.H., Chao, M.V., Jaenisch, R. Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. (1992) Cell. 69(5):737-49.

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Rosen, J.M., Bayna, E., Lee, K.F. Analysis of milk protein gene expression in transgenic mice. (1989) Molecular Biology & Medicine. 6(6):501-9.


Rosen, J.M., Poyet, P., Goodman, H., Lee, K.F. Mechanisms by which prolactin and glucocorticoids regulate casein gene expression. (1989) Biochemical Society Symposium. 55:115-23.


Lee, K.F., Atiee, S.H., Henning, S.J., Rosen, J.M. Relative contribution of promoter and intragenic sequences in the hormonal regulation of rat beta-casein transgenes. (1989) Molecular Endocrinology. 3(3):447-53. DOI: 10.1210/mend-3-3-447

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Lee, K.F., Atiee, S.H., Rosen, J.M. Differential regulation of rat beta-casein-chloramphenicol acetyltransferase fusion gene expression in transgenic mice. (1989) Molecular and Cellular Biology. 9(2):560-5.

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Lee, K.F., DeMayo, F.J., Atiee, S.H., Rosen, J.M. Tissue-specific expression of the rat beta-casein gene in transgenic mice. (1988) Nucleic Acids Research. 16(3):1027-41.

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Education

Plant Pathology, National Taiwan University
MS, Cancer Enzymology and Cell Differentiation, National Yang-Ming Medical College, Taiwan
PhD, Endocrinology, Baylor College of Medicine, Houston
Postdoctoral Fellow, Whitehead Institute for Biomedical Research

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