Kay Tye

Professor

Systems Neurobiology Laboratory

Wylie Vale Chair

Salk Institute for Biological Studies - Publications

all Publications


Tomova, L., Tye, K., Saxe, R. The Neuroscience of Unmet Social Needs. (2019) Social Neuroscience. DOI: 10.1080/17470919.2019.1694580

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Siciliano, C.A., Noamany, H., Chang, C.J., Brown, A.R., Chen, X., Leible, D., Lee, J.J., Wang, J., Vernon, A.N., Vander Weele, C.M., Kimchi, E.Y., Heiman, M., Tye, K.M. A cortical-brainstem circuit predicts and governs compulsive alcohol drinking. (2019) Science. 366(6468):1008-1012. DOI: 10.1126/science.aay1186

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Padilla-Coreano, N., Canetta, S., Mikofsky, R.M., Alway, E., Passecker, J., Myroshnychenko, M.V., Garcia-Garcia, A.L., Warren, R., Teboul, E., Blackman, D.R., Morton, M.P., Hupalo, S., Tye, K.M., Kellendonk, C., Kupferschmidt, D.A., Gordon, J.A. Hippocampal-Prefrontal Theta Transmission Regulates Avoidance Behavior. (2019) Neuron. DOI: 10.1016/j.neuron.2019.08.006

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Mobbs, D., Adolphs, R., Fanselow, M.S., Barrett, L.F., LeDoux, J.E., Ressler, K., Tye, K.M. Viewpoints: Approaches to defining and investigating fear. (2019) Nature Neuroscience. DOI: 10.1038/s41593-019-0456-6


Matthews, G.A., Tye, K.M. Neural mechanisms of social homeostasis. (2019) Ann. N. Y. Acad. Sci. DOI: 10.1111/nyas.14016

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Siciliano, C.A., Tye, K.M. Leveraging calcium imaging to illuminate circuit dysfunction in addiction. (2019) Alcohol. 74:47-63. DOI: 10.1016/j.alcohol.2018.05.013

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Weele, C.M.V., Siciliano, C.A., Tye, K.M. Dopamine tunes prefrontal outputs to orchestrate aversive processing. (2018) Brain Research. DOI: 10.1016/j.brainres.2018.11.044

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Vander Weele, C.M., Siciliano, C.A., Matthews, G.A., Namburi, P., Izadmehr, E.M., Espinel, I.C., Nieh, E.H., Schut, E.H.S., Padilla-Coreano, N., Burgos-Robles, A., Chang, C.J., Kimchi, E.Y., Beyeler, A., Wichmann, R., Wildes, C.P., Tye, K.M. Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli. (2018) Nature. 563(7731):397-401. DOI: 10.1038/s41586-018-0682-1

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Siciliano, C.A., Mills, F., Tye, K.M. Double threat in striatal dopamine signaling. (2018) Nature Neuroscience. 21(10):1296-1297. DOI: 10.1038/s41593-018-0243-9


Tye, K.M. Neural Circuit Motifs in Valence Processing. (2018) Neuron. 100(2):436-452. DOI: 10.1016/j.neuron.2018.10.001

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Allsop, S.A., Wichmann, R., Mills, F., Burgos-Robles, A., Chang, C.J., Felix-Ortiz, A.C., Vienne, A., Beyeler, A., Izadmehr, E.M., Glober, G., Cum, M.I., Stergiadou, J., Anandalingam, K.K., Farris, K., Namburi, P., Leppla, C.A., Weddington, J.C., Nieh, E.H., Smith, A.C., Ba, D., Brown, E.N., Tye, K.M. Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning. (2018) Cell. 173(6):1329-1342.e18. DOI: 10.1016/j.cell.2018.04.004

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Tye, K.M., Uchida, N. Editorial overview: Neurobiology of behavior. (2018) Current Opinion in Neurobiology. 49:iv-ix. DOI: 10.1016/j.conb.2018.02.019


Chatterjee, S., Sullivan, H.A., MacLennan, B.J., Xu, R., Hou, Y., Lavin, T.K., Lea, N.E., Michalski, J.E., Babcock, K.R., Dietrich, S., Matthews, G.A., Beyeler, A., Calhoon, G.G., Glober, G., Whitesell, J.D., Yao, S., Cetin, A., Harris, J.A., Zeng, H., Tye, K.M., Reid, R.C., Wickersham, I.R. Nontoxic, double-deletion-mutant rabies viral vectors for retrograde targeting of projection neurons. (2018) Nature Neuroscience. 21(4):638-646. DOI: 10.1038/s41593-018-0091-7

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Beyeler, A., Chang, C.J., Silvestre, M., Lévêque, C., Namburi, P., Wildes, C.P., Tye, K.M. Organization of Valence-Encoding and Projection-Defined Neurons in the Basolateral Amygdala. (2018) Cell Reports. 22(4):905-918. DOI: 10.1016/j.celrep.2017.12.097

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Wang, W., Wildes, C.P., Pattarabanjird, T., Sanchez, M.I., Glober, G.F., Matthews, G.A., Tye, K.M., Ting, A.Y. A light- and calcium-gated transcription factor for imaging and manipulating activated neurons. (2017) Nature Biotechnology. 35(9):864-871. DOI: 10.1038/nbt.3909

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Wei, D., Allsop, S., Tye, K., Piomelli, D. Endocannabinoid Signaling in the Control of Social Behavior. (2017) Trends in Neurosciences. 40(7):385-396. DOI: 10.1016/j.tins.2017.04.005

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Burgos-Robles, A., Kimchi, E.Y., Izadmehr, E.M., Porzenheim, M.J., Ramos-Guasp, W.A., Nieh, E.H., Felix-Ortiz, A.C., Namburi, P., Leppla, C.A., Presbrey, K.N., Anandalingam, K.K., Pagan-Rivera, P.A., Anahtar, M., Beyeler, A., Tye, K.M. Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment. (2017) Nature Neuroscience. 20(6):824-835. DOI: 10.1038/nn.4553

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Matthews, G.A., Tye, K.M. A New Handle for a Hot Topic: Genetic Markers for Warm-Sensing. (2016) Cell. 167(1):43-44. DOI: 10.1016/j.cell.2016.09.016

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Nieh, E.H., Vander Weele, C.M., Matthews, G.A., Presbrey, K.N., Wichmann, R., Leppla, C.A., Izadmehr, E.M., Tye, K.M. Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation. (2016) Neuron. 90(6):1286-1298. DOI: 10.1016/j.neuron.2016.04.035

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Namburi, P., Al-Hasani, R., Calhoon, G.G., Bruchas, M.R., Tye, K.M. Architectural Representation of Valence in the Limbic System. (2016) Neuropsychopharmacology. 41(7):1697-715. DOI: 10.1038/npp.2015.358

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Felix-Ortiz, A.C., Burgos-Robles, A., Bhagat, N.D., Leppla, C.A., Tye, K.M. Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex. (2016) Neuroscience. 321:197-209. DOI: 10.1016/j.neuroscience.2015.07.041

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Beyeler, A., Namburi, P., Glober, G.F., Simonnet, C., Calhoon, G.G., Conyers, G.F., Luck, R., Wildes, C.P., Tye, K.M. Divergent Routing of Positive and Negative Information from the Amygdala during Memory Retrieval. (2016) Neuron. 90(2):348-361. DOI: 10.1016/j.neuron.2016.03.004

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Matthews, G.A., Nieh, E.H., Vander Weele, C.M., Halbert, S.A., Pradhan, R.V., Yosafat, A.S., Glober, G.F., Izadmehr, E.M., Thomas, R.E., Lacy, G.D., Wildes, C.P., Ungless, M.A., Tye, K.M. Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation. (2016) Cell. 164(4):617-31. DOI: 10.1016/j.cell.2015.12.040

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Sidor, M.M., Spencer, S.M., Dzirasa, K., Parekh, P.K., Tye, K.M., Warden, M.R., Arey, R.N., Enwright, J.F., Jacobsen, J.P., Kumar, S., Remillard, E.M., Caron, M.G., Deisseroth, K., McClung, C.A. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. (2015) Molecular Psychiatry. 20(11):1406-19. DOI: 10.1038/mp.2014.167

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Sidor, M.M., Spencer, S.M., Dzirasa, K., Parekh, P.K., Tye, K.M., Warden, M.R., Arey, R.N., Enwright, J.F., Jacobsen, J.P., Kumar, S., Remillard, E.M., Caron, M.G., Deisseroth, K., McClung, C.A. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. (2015) Molecular Psychiatry. 20(11):1479-80. DOI: 10.1038/mp.2015.8


Calhoon, G.G., Tye, K.M. Resolving the neural circuits of anxiety. (2015) Nature Neuroscience. 18(10):1394-404. DOI: 10.1038/nn.4101

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Adamantidis, A., Arber, S., Bains, J.S., Bamberg, E., Bonci, A., Buzsáki, G., Cardin, J.A., Costa, R.M., Dan, Y., Goda, Y., Graybiel, A.M., Häusser, M., Hegemann, P., Huguenard, J.R., Insel, T.R., Janak, P.H., Johnston, D., Josselyn, S.A., Koch, C., Kreitzer, A.C., Lüscher, C., Malenka, R.C., Miesenböck, G., Nagel, G., Roska, B., Schnitzer, M.J., Shenoy, K.V., Soltesz, I., Sternson, S.M., Tsien, R.W., Tsien, R.Y., Turrigiano, G.G., Tye, K.M., Wilson, R.I. Optogenetics: 10 years after ChR2 in neurons--views from the community. (2015) Nature Neuroscience. 18(9):1202-12. DOI: 10.1038/nn.4106


Namburi, P., Beyeler, A., Yorozu, S., Calhoon, G.G., Halbert, S.A., Wichmann, R., Holden, S.S., Mertens, K.L., Anahtar, M., Felix-Ortiz, A.C., Wickersham, I.R., Gray, J.M., Tye, K.M. A circuit mechanism for differentiating positive and negative associations. (2015) Nature. 520(7549):675-8. DOI: 10.1038/nature14366

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Nieh, E.H., Matthews, G.A., Allsop, S.A., Presbrey, K.N., Leppla, C.A., Wichmann, R., Neve, R., Wildes, C.P., Tye, K.M. Decoding neural circuits that control compulsive sucrose seeking. (2015) Cell. 160(3):528-41. DOI: 10.1016/j.cell.2015.01.003

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Janak, P.H., Tye, K.M. From circuits to behaviour in the amygdala. (2015) Nature. 517(7534):284-92. DOI: 10.1038/nature14188

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Sidor, M.M., Davidson, T.J., Tye, K.M., Warden, M.R., Diesseroth, K., McClung, C.A. In vivo optogenetic stimulation of the rodent central nervous system. (2015) JoVE.(95):51483 DOI: 10.3791/51483

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Tye, K.M. Neural circuit reprogramming: a new paradigm for treating neuropsychiatric disease? (2014) Neuron. 83(6):1259-61. DOI: 10.1016/j.neuron.2014.08.022

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Chuong, A.S., Miri, M.L., Busskamp, V., Matthews, G.A., Acker, L.C., Sørensen, A.T., Young, A., Klapoetke, N.C., Henninger, M.A., Kodandaramaiah, S.B., Ogawa, M., Ramanlal, S.B., Bandler, R.C., Allen, B.D., Forest, C.R., Chow, B.Y., Han, X., Lin, Y., Tye, K.M., Roska, B., Cardin, J.A., Boyden, E.S. Noninvasive optical inhibition with a red-shifted microbial rhodopsin. (2014) Nature Neuroscience. 17(8):1123-9. DOI: 10.1038/nn.3752

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Allsop, S.A., Vander Weele, C.M., Wichmann, R., Tye, K.M. Optogenetic insights on the relationship between anxiety-related behaviors and social deficits. (2014) Front Behav Neurosci. 8:241. DOI: 10.3389/fnbeh.2014.00241

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Gunaydin, L.A., Grosenick, L., Finkelstein, J.C., Kauvar, I.V., Fenno, L.E., Adhikari, A., Lammel, S., Mirzabekov, J.J., Airan, R.D., Zalocusky, K.A., Tye, K.M., Anikeeva, P., Malenka, R.C., Deisseroth, K. Natural neural projection dynamics underlying social behavior. (2014) Cell. 157(7):1535-51. DOI: 10.1016/j.cell.2014.05.017

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Beyeler, A., Eckhardt, C.A., Tye, K.M. Deciphering memory function with optogenetics. (2014) Prog Mol Biol Transl Sci. 122:341-90. DOI: 10.1016/B978-0-12-420170-5.00012-X

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Haws, M.E., Jaramillo, T.C., Espinosa, F., Widman, A.J., Stuber, G.D., Sparta, D.R., Tye, K.M., Russo, S.J., Parada, L.F., Stavarache, M., Kaplitt, M., Bonci, A., Powell, C.M. PTEN knockdown alters dendritic spine/protrusion morphology, not density. (2014) Journal of Comparative Neurology. 522(5):1171-90. DOI: 10.1002/cne.23488

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Lammel, S., Tye, K.M., Warden, M.R. Progress in understanding mood disorders: optogenetic dissection of neural circuits. (2014) Genes, Brain, and Behavior. 13(1):38-51. DOI: 10.1111/gbb.12049

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Felix-Ortiz, A.C., Tye, K.M. Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior. (2014) Journal of Neuroscience. 34(2):586-95. DOI: 10.1523/JNEUROSCI.4257-13.2014

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Felix-Ortiz, A.C., Beyeler, A., Seo, C., Leppla, C.A., Wildes, C.P., Tye, K.M. BLA to vHPC inputs modulate anxiety-related behaviors. (2013) Neuron. 79(4):658-64. DOI: 10.1016/j.neuron.2013.06.016

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Nieh, E.H., Kim, S.Y., Namburi, P., Tye, K.M. Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors. (2013) Brain Research. 1511:73-92. DOI: 10.1016/j.brainres.2012.11.001

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Kim, S.Y., Adhikari, A., Lee, S.Y., Marshel, J.H., Kim, C.K., Mallory, C.S., Lo, M., Pak, S., Mattis, J., Lim, B.K., Malenka, R.C., Warden, M.R., Neve, R., Tye, K.M., Deisseroth, K. Diverging neural pathways assemble a behavioural state from separable features in anxiety. (2013) Nature. 496(7444):219-23. DOI: 10.1038/nature12018

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Tye, K.M., Mirzabekov, J.J., Warden, M.R., Ferenczi, E.A., Tsai, H.C., Finkelstein, J., Kim, S.Y., Adhikari, A., Thompson, K.R., Andalman, A.S., Gunaydin, L.A., Witten, I.B., Deisseroth, K. Dopamine neurons modulate neural encoding and expression of depression-related behaviour. (2013) Nature. 493(7433):537-541. DOI: 10.1038/nature11740

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Warden, M.R., Selimbeyoglu, A., Mirzabekov, J.J., Lo, M., Thompson, K.R., Kim, S.Y., Adhikari, A., Tye, K.M., Frank, L.M., Deisseroth, K. A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge. (2012) Nature. 492(7429):428-32. DOI: 10.1038/nature11617

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Tye, K.M. Glutamate inputs to the nucleus accumbens: does source matter? (2012) Neuron. 76(4):671-3. DOI: 10.1016/j.neuron.2012.11.008

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Lammel, S., Lim, B.K., Ran, C., Huang, K.W., Betley, M.J., Tye, K.M., Deisseroth, K., Malenka, R.C. Input-specific control of reward and aversion in the ventral tegmental area. (2012) Nature. 491(7423):212-7. DOI: 10.1038/nature11527

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Tye, K.M., Deisseroth, K. Optogenetic investigation of neural circuits underlying brain disease in animal models. (2012) Nature Reviews. Neuroscience. 13(4):251-66. DOI: 10.1038/nrn3171

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Tan, K.R., Yvon, C., Turiault, M., Mirzabekov, J.J., Doehner, J., Labouèbe, G., Deisseroth, K., Tye, K.M., Lüscher, C. GABA neurons of the VTA drive conditioned place aversion. (2012) Neuron. 73(6):1173-83. DOI: 10.1016/j.neuron.2012.02.015

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Mattis, J., Tye, K.M., Ferenczi, E.A., Ramakrishnan, C., O'Shea, D.J., Prakash, R., Gunaydin, L.A., Hyun, M., Fenno, L.E., Gradinaru, V., Yizhar, O., Deisseroth, K. Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins. (2011) Nature Methods. 9(2):159-72. DOI: 10.1038/nmeth.1808

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Witten, I.B., Steinberg, E.E., Lee, S.Y., Davidson, T.J., Zalocusky, K.A., Brodsky, M., Yizhar, O., Cho, S.L., Gong, S., Ramakrishnan, C., Stuber, G.D., Tye, K.M., Janak, P.H., Deisseroth, K. Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. (2011) Neuron. 72(5):721-33. DOI: 10.1016/j.neuron.2011.10.028

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Stuber, G.D., Sparta, D.R., Stamatakis, A.M., van Leeuwen, W.A., Hardjoprajitno, J.E., Cho, S., Tye, K.M., Kempadoo, K.A., Zhang, F., Deisseroth, K., Bonci, A. Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. (2011) Nature. 475(7356):377-80. DOI: 10.1038/nature10194

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Berndt, A., Schoenenberger, P., Mattis, J., Tye, K.M., Deisseroth, K., Hegemann, P., Oertner, T.G. High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels. (2011) Proceedings of the National Academy of Sciences of the United States of America. 108(18):7595-600. DOI: 10.1073/pnas.1017210108

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Tye, K.M., Prakash, R., Kim, S.Y., Fenno, L.E., Grosenick, L., Zarabi, H., Thompson, K.R., Gradinaru, V., Ramakrishnan, C., Deisseroth, K. Amygdala circuitry mediating reversible and bidirectional control of anxiety. (2011) Nature. 471(7338):358-62. DOI: 10.1038/nature09820

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Tye, K.M., Tye, L.D., Cone, J.J., Hekkelman, E.F., Janak, P.H., Bonci, A. Methylphenidate facilitates learning-induced amygdala plasticity. (2010) Nature Neuroscience. 13(4):475-81. DOI: 10.1038/nn.2506

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Hopf, F.W., Bowers, M.S., Chang, S.J., Chen, B.T., Martin, M., Seif, T., Cho, S.L., Tye, K., Bonci, A. Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence. (2010) Neuron. 65(5):682-94. DOI: 10.1016/j.neuron.2010.02.015

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Stuber, G.D., Hopf, F.W., Tye, K.M., Chen, B.T., Bonci, A. Neuroplastic alterations in the limbic system following cocaine or alcohol exposure. (2010) Current Topics in Behavioral Neurosciences. 3:3-27. DOI: 10.1007/7854_2009_23

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Tye, K.M., Cone, J.J., Schairer, W.W., Janak, P.H. Amygdala neural encoding of the absence of reward during extinction. (2010) Journal of Neuroscience. 30(1):116-25. DOI: 10.1523/JNEUROSCI.4240-09.2010

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Tye, K.M., Stuber, G.D., de Ridder, B., Bonci, A., Janak, P.H. Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning. (2008) Nature. 453(7199):1253-7. DOI: 10.1038/nature06963

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Tye, K.M., Janak, P.H. Amygdala neurons differentially encode motivation and reinforcement. (2007) Journal of Neuroscience. 27(15):3937-45. DOI: 10.1523/JNEUROSCI.5281-06.2007

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Education

BS, Brain and Cognitive Sciences, Minor in Biology, Massachusetts Institute of Technology
PhD, Neuroscience, University of California at San Francisco


Affiliations