Gerald Shadel, PhD

Professor

Molecular and Cell Biology Laboratory

Audrey Geisel Chair in Biomedical Science
Director, San Diego-Nathan Shock Center of Excellence in the Basic Biology of Aging

Gerald Shadel
Salk Institute for Biological Studies - News

News


Faulty DNA disposal system causes inflammation

LA JOLLA—Cells in the human body contain power-generating mitochondria, each with their own mtDNA—a unique set of genetic instructions entirely separate from the cell’s nuclear DNA that mitochondria use to …


Rewiring tumor mitochondria enhances the immune system’s ability to recognize and fight cancer

LA JOLLA—Immunotherapy, which uses the body’s own immune system to fight cancer, is an effective treatment option, yet many patients do not respond to it. Thus, cancer researchers are seeking …


Telomeres, mitochondria, and inflammation oh my! Three hallmarks of aging work together to prevent cancer

Telomeres protect the ends of chromosomes from damage. This image shows telomeres (green) and DNA (blue) during DNA repair activities.Click here for a high-resolution image.Credit: Salk Institute

LA JOLLA—As we age, …


San Diego Nathan Shock Center leverages long-running human study to enable cellular research on diversity of aging

LA JOLLA—The San Diego Nathan Shock Center of Excellence in the Basic Biology of Aging, a collaboration between the Salk Institute, UC San Diego, and Sanford Burnham Prebys, received new …


Scientists find surprising link between mitochondrial DNA and increased atherosclerosis risk

LA JOLLA— Mitochondria are known as cells’ powerhouses, but mounting evidence suggests they also play a role in inflammation. Scientists from the Salk Institute and UC San Diego published new …


San Diego Nathan Shock Center announces pilot grant awardees

LA JOLLA—The San Diego Nathan Shock Center (SD-NSC) of Excellence in the Basic Biology of Aging, a consortium between the Salk Institute for Biological Studies, Sanford Burnham Prebys (SBP) and …


Peter Adams and Gerald Shadel awarded $13 million from NIH to study aging and liver cancer

LA JOLLA—Sanford Burnham Prebys Professor Peter D. Adams, who directs the Aging, Cancer and Immuno-oncology Program, and Salk Institute Professor Gerald Shadel, who directs the San Diego Nathan Shock Center …


Top San Diego research institutions, led by Salk, to receive an expected $5 million to study cellular aging in humans

LA JOLLA—The Salk Institute will establish a world-class San Diego Nathan Shock Center (SD-NSC), a consortium with Sanford Burnham Prebys Medical Discovery Institute and the University of California San Diego …


Mitochondria are the “canary in the coal mine” for cellular stress

LA JOLLA—Mitochondria, tiny structures present in most cells, are known for their energy-generating machinery. Now, Salk researchers have discovered a new function of mitochondria: they set off molecular alarms when …


Salk awarded $19.2 million by the American Heart Association-Allen Initiative to study Alzheimer’s and aging in the brain

LA JOLLA—A team of Salk Institute researchers led by President Rusty Gage has been awarded $19.2 million over eight years by the American Heart Association-Allen Initiative in Brain Health and …


Cells agree: what doesn’t kill you makes you stronger

LA JOLLA—We’ve all heard the expression: “what doesn’t kill you makes you stronger.” Now, research led by a Salk Institute scientist suggests why, at a cellular level, this might be …


An ATM that dispenses antioxidants

LA JOLLA—One reason we’re supposed to eat a variety of colorful fruits and vegetables is because they contain nutritious compounds called antioxidants. These molecules counteract the damage to our bodies …


Three Salk faculty honored with endowed chairs

LA JOLLA—Salk scientists Katherine Jones, Susan Kaech and Gerald Shadel each have been recognized for their contributions and dedication to advancing science through research by being named to endowed chairs at …


Prominent scientists in immunobiology and aging research to join Salk Institute

LA JOLLA—The Salk Institute is honored to welcome two new faculty with the rank of full professor, both of whom are highly respected and accomplished leaders in their fields. Susan …


Education

BS, Chemistry, University of Nevada, Las Vegas
PhD, Texas A&M University
Postdoctoral Fellow, Stanford University


Awards & Honors

  • The Glenn Foundation’s Glenn Award for Research in Biological Mechanisms of Aging, 2011
  • Amgen Outstanding Investigator Award, 2007
  • The Glenn/AFAR Breakthroughs In Gerontology Award, 2006