Dannielle Engle

Assistant Professor

Regulatory Biology Laboratory

Salk Institute for Biological Studies - Publications

Publications


1. Yunyuan V. Wang, Mathias Leblanc, Norma Fox, Jian-Hua Mao, Kelsey L. Tinkum, Kurt Krummel, Dannielle D. Engle, David Piwnica-Worms, Helen Piwnica-Worms, Allan Balmain, Kenneth Kaushansky Geoffrey M. Wahl. (2011). Fine-Tuning p53 Activity Through C-terminal Modification Significantly Contributes to HSC Homeostasis and Mouse Radiosensitivity. Genes Dev 25, 1426-1438.

2. Benjamin T. Spike*, Dannielle D. Engle*, Jennifer C. Lin*, Samantha K. Cheung, Justin La, Geoffrey M. Wahl. (2012). A Mammary Stem Cell Population Identified and Characterized in Late Embryogenesis Reveals Similarities to Human Breast Cancer. Cell Stem Cell 10, 183-197. * Co-first authors.

3. Mara H. Sherman, Ruth T. Yu, Dannielle D. Engle, Ning Ding, Annette R. Atkins, Hervé Tiriac, Eric A. Collisson, Frances Connor, Terry Van Dyke, Serguei Kozlov, Philip Martin, Tiffany W. Tseng, David W. Dawson, Timothy R. Donahue, Atsushi Masamune, Tooru Shimosegawa, Minoti V. Apte, Jeremy S. Wilson, Beverly Ng, Sue Lynn Lau, Jenny E. Gunton, Geoffrey M. Wahl, Tony Hunter, Jeffrey A. Drebin, Peter J. O’Dwyer, Christopher Liddle, David Tuveson, Michael Downes, Ronald M. Evans. (2014). Vitamin D Receptor-Mediated Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy. Cell 159, 80-93.

4. Ishan Roy, Donna M. McAllister, Egal Gorse, Kate Dixon, Clinton T. Piper, Noah P. Zimmerman, Anthony E Getschman, Susan Tsai, Dannielle D. Engle, Douglas B. Evans, Brian F. Volkman, Balaraman Kalyamaraman, Michael B. Dwinell. (2015). Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine- Biased Agonism and Bioenergetic Signaling. Cancer Res 75, 3529-3542.

5. Adam Naguib, Gyula Bencze, Dannielle D. Engle, Iok I.C. Chio, Tali Herzka, Kaitlin Watrud, Szilvia Bencze, David A. Tuveson, Darryl J. Pappin, Lloyd C. Trotman. (2015). P53 Mutations Change Phosphatidylinositol Acyl Chain Composition. Cell Reports 10, 8-19.

6. Sylvia F. Boj*, Chang-Il Hwang*, Lindsey A. Baker*, Iok In Christine Chio*, Dannielle D. Engle*, Vincenzo Corbo*, Myrthe Jager*, Mariano Ponz-Sarvise, Hervé Tiriac, Mona S. Spector, Ana Gracanin, Tobiloba Oni, Kenneth H. Yu, Ruben van Boxtel, Meritxell Huch, Keith D. Rivera, John P. Wilson, Michael E. Feigin, Daniel Öhlund, Abram Handly-Santana, Christine M. Ardito-Abraham, Michael Ludwig, Ela Elyada, Brinda Alagesan, Giulia Biffi, Georgi N. Yordanov, Bethany Delcuze, Brianna Creighton, Kevin Wright, Youngkyu Park, Folkert H.M. Morsink, I. Quintus Molenaar, Inne H. Borel Rinkes, Edwin Cuppen, Yuan Hao, Ying Jin, Isaac J. Nijman, Christine Iacobuzio-Donahue, Steven D. Leach, Darryl J. Pappin, Molly Hammell, David S. Klimstra, Olca Basturk, Ralph H. Hruban, George Johan Offerhaus, Robert G.J. Vries, Hans Clevers, David A. Tuveson. (2015). Organoid Models of Human and Mouse Ductal Pancreatic Cancer. Cell 160, 324-338. * Co-first authors

7. Constantinos P. Zambirinis, Elliot Levie, Susanna Nguy, Antonina Avanzi, Rocky M. Barilla, Yijie Xu, Lena Tomkötter, Donnele Daley, Stephanie H. Greco, Michael Deutsch, Saikiran Jonnadula, Alejandro Torres-Hernandez, Daniel Tippens, Smruti Pushalkar, Andrew Eisenthal, Deepak Saxena, Jiyoung Ahn, Cristina H. Hajdu, Dannielle D. Engle, David A. Tuveson, George Miller. (2015). TLR9 Ligation in Pancreatic Stellate Cells Promotes Tumorigenesis. J Exp Med 212, 2077-2094.

8. Lena Tomkötter*, Gregor Werba*, Shaun Tiwari, Nancy Ngoc Giao Ly, Sara Alothman, Dalia Alqunaibit, Antonina Avanzi, Rocky Barilla, Donnele Daley, Stephanie H. Greco, Alejandro Torres-Hernandez, Matthew Pergamo, Atsuo Ochi, Constantinos P. Zambirinis, Mridul Pansar1, Mauricio Rendon, Daniel Tippens, Mautin Hundeyin, Vishnu R. Mani, Cristina Hajdu, Dannielle D. Engle, George Miller. (2016). The Necrosome Promotes Pancreatic Oncogenesis via CXCL1 and Mincle-Induced Immune Suppression. Nature 532, 245-249. * Co-first authors

9. Sebastian Nielsen, Valeria Quaranta, Andrea Linford, Perpetua Emeagi, Carolyn Rainer, Almudena Santos, Lucy Ireland, Takao Sakai, Keiko Sakai, Yong-Sam Kim, Dannielle D. Engle, Fiona Campbell, Daniel Palmer, Jeong Heon Ko, David Tuveson, Emilio Hirsch, Ainhoa Mielgo, and Michael Schmid. (2016). Macrophage-Secreted Granulin Supports Pancreatic Cancer Metastasis by Inducing Liver Fibrosis. Nature Cell Biology 18, 549-560.

10. Lucy Ireland, Almudena Santos, Muhammad S. Ahmed, Carolyn Rainer, Sebastian R. Nielsen, Valeria Quaranta, Ulrike Weyer-Czernilofsky, Dannielle D. Engle, Pedro A. Perez-Mancera, Sarah E. Coupland, Azzam Taktak, Thomas Bogenrieder, David A. Tuveson, Fiona Campbell, Michael C. Schmid and Ainhoa Mielgo. (2016). Chemoresistance in Pancreatic Cancer is Driven by Stroma-Derived Insulin-Like Growth Factors. Cancer Research 76, 6851-63.

11. Daniel Öhlund, Abram Handly-Santana, Giulia Biffi, Ela Elyada, Ana Almeida, Mariano Ponz-Sarvise, Vincenzo Corbo, Tobiloba Oni, Stephen Hearn, Eun Jung Lee, Iok In Christine Chio, Chang-Il Hwang, Hervé Tiriac, Lindsey Baker, Dannielle D. Engle, Mikala Egeblad, Douglas Fearon, James Crawford, Hans Clevers, Youngkyu Park, and David Tuveson. (2017). Distinct Populations of Inflammatory Fibroblasts and Myofibroblasts in Pancreatic Cancer. J Exp Med 214, 579-596.

12. Robert A. Wolff*, Andrea Wang-Gillam*, Hector Alvarez*, Hervé Tiriac*, Dannielle Engle*, Shurong Hou*, Abigail F. Groff, Anthony San Lucas, Vincent Bernard, Kelvin Allenson, Jonathan Castillo, Dong Kim, Feven Mulu, Jonathan Huang, Bret Stephens, Ignacio I. Wistuba, Matthew Katz, Gauri Varadhachary, Youngkyu Park, James Hicks, Arul Chinnaiyan, Louis Scampavia, Timothy Spicer, Chiara Gerhardinger, Anirban Maitra, David Tuveson, John Rinn, Gregory Lizee, Cassian Yee, Arnold J. Levine. (2018). Dynamic changes during the treatment of pancreatic cancer. Oncotarget 9, 14764-14790. * Co-first authors

13. Hervé Tiriac, Pascal Belleau*, Dannielle D. Engle*, Dennis Plenker, Astrid Deschênes, Timothy D. D. Somerville, Fieke E. M. Froeling, Richard A. Burkhart, Robert E. Denroche, Gun-Ho Jang, Koji Miyabayashi, C. Megan Young, Hardik Patel, Michelle Ma, Joseph F. LaComb, Randze Lerie D. Palmaira, Ammar A. Javed, Jasmine C. Huynh, Molly Johnson, Kanika Arora, Nicolas Robine, Minita Shah, Rashesh Sanghvi, Austin B. Goetz, Cynthya Yabar- Lowder, Laura Martello, Else Driehuis, Nicolas LeComte, Gokce Askan, Christine A. Iacobuzio-Donahue, Hans Clevers, Laura D. Wood, Ralph H. Hruban, Elizabeth Thompson, Andrew J. Aguirre, Brian M. Wolpin, Aaron Sasson, Joseph Kim, Maoxin Wu, Juan Carlos Bucobo, Peter Allen, Divyesh V. Sejpal, William Nealon, James D. Sullivan, Jordan M. Winter, Phyllis A. Gimotty, Jean L. Grem, Dominick J. DiMaio, Jonathan M. Buscaglia, Paul M. Grandgenett, Jonathan R. Brody, Michael A. Hollingsworth, Grainne M. O’Kane, Faiyaz Notta, Edward Kim, James M. Crawford, Craig Devoe, Allyson Ocean, Christopher L. Wolfgang, Kenneth H. Yu, Ellen Li, Christopher R. Vakoc, Benjamin Hubert, Sandra E. Fischer, Julie M. Wilson, Richard Moffitt, Jennifer Knox, Alexander Krasnitz, Steven Gallinger, David A. Tuveson (In Press). Organoid Profiling Parallels Therapeutic Response in Pancreatic Cancer Patients. Cancer Discovery. *Equal Contribution.

14. Dannielle D. Engle, Hervé Tiriac, Keith D. Rivera, Arnaud Pommier, Sean Whalen, Tobiloba E. Oni, Brinda Alagesan, Eun Jung Lee, Melissa A. Yao, Matthew S. Lucito, Benjamin Spielman, Brandon Da Silva, Christina Schoepfer, Kevin Wright, Brianna Creighton, Lauren Afinowicz, Kenneth Yu, Robert Grützmann, Daniela Aust, Phyllis A. Gimotty, Katherine S. Pollard, Ralph H. Hruban, Michael G. Goggins, Christian Pilarsky, Youngkyu Park, Darryl J. Pappin, Michael A. Hollingsworth, David A. Tuveson (2019). The Glycan CA19-9 Promotes Pancreatitis and Pancreatic Cancer in Mice. Science

Education

BA, Biological Sciences and Asian Studies, Northwestern University
PhD, Biological Sciences, University of California, San Diego


Awards & Honors

  • 2016 - 2018 NIH NCI Career Transition K99/R00 Award
  • 2009 -2011 California Breast Cancer Research Program Fellowship
  • 2005 - 2009 UCSD Chancellor’s Fellowship

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