Clodagh O’Shea

Professor

Molecular and Cell Biology Laboratory

Howard Hughes Medical Institute Faculty Scholar

Wicklow Chair

Salk Institute for Biological Studies - Publications

all Publications


Dekker, J., Belmont, A.S., Guttman, M., Leshyk, V.O., Lis, J.T., Lomvardas, S., Mirny, L.A., O'Shea, C.C., Park, P.J., Ren, B., Politz, J.C.R., Shendure, J., Zhong, S., 4D Nucleome Network. The 4D nucleome project. (2017) Nature. 549(7671):219-226. DOI: 10.1038/nature23884

+ expand abstract


Ou, H.D., Phan, S., Deerinck, T.J., Thor, A., Ellisman, M.H., O'Shea, C.C. ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells. (2017) Science. 357(6349). DOI: 10.1126/science.aag0025

+ expand abstract


Tufail, Y., Cook, D., Fourgeaud, L., Powers, C.J., Merten, K., Clark, C.L., Hoffman, E., Ngo, A., Sekiguchi, K.J., O'Shea, C.C., Lemke, G., Nimmerjahn, A. Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia. (2017) Neuron. 93(3):574-586.e8. DOI: 10.1016/j.neuron.2016.12.021

+ expand abstract


Ou, H.D., Deerinck, T.J., Bushong, E., Ellisman, M.H., O, C.C. Visualizing viral protein structures in cells using genetic probes for correlated light and electron microscopy. (2015) Methods. 90:39-48. DOI: 10.1016/j.ymeth.2015.06.002

+ expand abstract


Higginbotham, J.M., O, C.C. Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains. (2015) J. Virol. 89(20):10260-72. DOI: 10.1128/JVI.01091-15

+ expand abstract


Shah, G.A., O, C.C. Viral and Cellular Genomes Activate Distinct DNA Damage Responses. (2015) Cell. 162(5):987-1002. DOI: 10.1016/j.cell.2015.07.058

+ expand abstract


Heimbucher, T., Liu, Z., Bossard, C., McCloskey, R., Carrano, A.C., Riedel, C.G., Tanasa, B., Klammt, C., Fonslow, B.R., Riera, C.E., Lillemeier, B.F., Kemphues, K., Yates, J.R., O, C., Hunter, T., Dillin, A. The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity. (2015) Cell Metab. 22(1):151-63. DOI: 10.1016/j.cmet.2015.06.002

+ expand abstract


Miyake-Stoner, S.J., O, C.C. Metabolism goes viral. (2014) Cell Metab. 19(4):549-50. DOI: 10.1016/j.cmet.2014.03.022

+ expand abstract


Ou, H.D., Kwiatkowski, W., Deerinck, T.J., Noske, A., Blain, K.Y., Land, H.S., Soria, C., Powers, C.J., May, A.P., Shu, X., Tsien, R.Y., Fitzpatrick, J.A., Long, J.A., Ellisman, M.H., Choe, S., O, C.C. A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors. (2012) Cell. 151(2):304-19. DOI: 10.1016/j.cell.2012.08.035

+ expand abstract


Ou, H.D., May, A.P., O'Shea, C.C. The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication. (2011) Wiley Interdiscip Rev Syst Biol Med. 3(1):48-73. DOI: 10.1002/wsbm.88

+ expand abstract


Espantman, K.C., O, C.C. aMAGEing new players enter the RING to promote ubiquitylation. (2010) Mol. Cell. 39(6):835-7. DOI: 10.1016/j.molcel.2010.09.006

+ expand abstract


Soria, C., Estermann, F.E., Espantman, K.C., O, C.C. Heterochromatin silencing of p53 target genes by a small viral protein. (2010) Nature. 466(7310):1076-81. DOI: 10.1038/nature09307

+ expand abstract


Iacovides, D.C., OShea, C.C., Oses-Prieto, J., Burlingame, A., McCormick, F. Critical role for arginine methylation in adenovirus-infected cells. (2007) J. Virol. 81(23):13209-17. DOI: 10.1128/JVI.01415-06

+ expand abstract


Ringshausen, I., O'Shea, C.C., Finch, A.J., Swigart, L.B., Evan, G.I. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. (2006) Cancer Cell. 10(6):501-14. DOI: 10.1016/j.ccr.2006.10.010

+ expand abstract


O'Shea, C.C. Viruses - seeking and destroying the tumor program. (2005) Oncogene. 24(52):7640-55. DOI: 10.1038/sj.onc.1209047

+ expand abstract


O'Shea, C.C. Viruses: tools for tumor target discovery, and agents for oncolytic therapies - an introduction. (2005) Oncogene. 24(52):7636-9. DOI: 10.1038/sj.onc.1209035


O'Shea, C.C., Soria, C., Bagus, B., McCormick, F. Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy. (2005) Cancer Cell. 8(1):61-74. DOI: 10.1016/j.ccr.2005.06.009

+ expand abstract


O'Shea, C.C., Choi, S., McCormick, F., Stokoe, D. Adenovirus overrides cellular checkpoints for protein translation. (2005) Cell Cycle. 4(7):883-8. DOI: 10.4161/cc.4.7.1791

+ expand abstract


O'Shea, C., Klupsch, K., Choi, S., Bagus, B., Soria, C., Shen, J., McCormick, F., Stokoe, D. Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. (2005) EMBO J. 24(6):1211-21. DOI: 10.1038/sj.emboj.7600597

+ expand abstract


O'Shea, C.C., Fried, M. Modulation of the ARF-p53 pathway by the small DNA tumor viruses. (2005) Cell Cycle. 4(3):449-52. DOI: 10.4161/cc.4.3.1555

+ expand abstract


O'Shea, C.C. DNA tumor viruses -- the spies who lyse us. (2005) Curr. Opin. Genet. Dev. 15(1):18-26. DOI: 10.1016/j.gde.2004.12.010

+ expand abstract


O'Shea, C.C., Johnson, L., Bagus, B., Choi, S., Nicholas, C., Shen, A., Boyle, L., Pandey, K., Soria, C., Kunich, J., Shen, Y., Habets, G., Ginzinger, D., McCormick, F. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. (2004) Cancer Cell. 6(6):611-23. DOI: 10.1016/j.ccr.2004.11.012

+ expand abstract


Education

BS, Biochemistry and Microbiology, University College Cork, Ireland
PhD, Imperial College London/Imperial Cancer Research Fund, U.K.
Postdoctoral Fellow, UCSF Comprehensive Cancer Center, San Francisco, U.S.A


Awards & Honors

  • 2018 Allen Distinguished Investigator Award
  • 2016 Howard Hughes Medical Institute Faculty Scholar
  • 2014 W. M. Keck Medical Research Program Award
  • 2014 Rose Hills Fellow
  • 2011Science/NSF International Science & Visualization Challenge, People's Choice
  • 2011 Anna Fuller Award for Cancer Research
  • 2010, 2011, 2012 Kavli Frontiers Fellow, National Academy of Sciences
  • 2009 Sontag Distinguished Scientist Award
  • 2009 American Cancer Society Research Scholar Award
  • 2008 ACGT Young Investigator Award for Cancer Gene Therapy
  • 2008 Arnold and Mabel Beckman Young Investigator Award
  • 2008 William Scandling Assistant Professor, Developmental Chair
  • 2007 Emerald Foundation Scholar