Costa, E.K., Chen, J., Guldner, I.H., Mboning, L., Schmahl, N., Tsenter, A., Nagvekar, R., Wu, M.R., Moran-Losada, P., Bouchard, L.S., Wang, S., Singh, P.P., Pellegrini, M., Brunet, A., Wyss-Coray, T. Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish. (2026) Nat Aging. 6(3):636-664. DOI: 10.1038/s43587-026-01074-6

Guldner, I.H.*, Wagner, V.P., Moran-Losada, P., Shi, S.M., Golub, S.W., Hevler, J.F., Chen, K., Meese, B.T., Ghoochani, A., Pulido, E., Oh, H.S., Le Guen, Y., Lu, N., Wong, P.S., To, N.S., Garceau, D., Guo, Z., Luo, J., Bertozzi, C.R., Lundberg, E., Abu-Remaileh, M., Sasner, M., Keller, A., Yang, A.C., Cheung, T.H., Wyss-Coray, T. Ageing promotes microglial accumulation of slow-degrading synaptic proteins. (2026) Nature. 650(8103):930-941. DOI: 10.1038/s41586-025-09987-9

Guldner, I.H.*, Wagner, V.P., Moran-Losada, P., Shi, S.M., Chen, K., Meese, B.T., Oh, H., Le Guen, Y., Lu, N., Wong, P.S., To, N.S., Garceau, D., Guo, Z., Luo, J., Sasner, M., Keller, A., Yang, A.C., Cheung, T., Wyss-Coray, T. Synaptic proteins that aggregate and degrade slower with aging accumulate in microglia. (2025) bioRxiv. DOI: 10.1101/2025.05.20.654652

Engel, A., Wagner, V., Hahn, O., Foltz, A.G., Atkins, M., Beganovic, A., Guldner, I.H., Lu, N., Saksena, A., Fischer, U., Ludwig, N., Meese, E., Wyss-Coray, T., Keller, A. A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase. (2025) Nature Communications. 16(1):4588. DOI: 10.1038/s41467-025-59860-6

Oh, H.S., Urey, D.Y., Karlsson, L., Zhu, Z., Shen, Y., Farinas, A., Timsina, J., Duggan, M.R., Chen, J., Guldner, I.H., Morshed, N., Yang, C., Western, D., Ali, M., Le Guen, Y., Trelle, A., Herukka, S.K., Rauramaa, T., Hiltunen, M., Lipponen, A., Luikku, A.J., Poston, K.L., Mormino, E., Wagner, A.D., Wilson, E.N., Channappa, D., Leinonen, V., Stevens, B., Ehrenberg, A.J., Gottesman, R.F., Coresh, J., Walker, K.A., Zetterberg, H., Bennett, D.A., Franzmeier, N., Hansson, O., Cruchaga, C., Wyss-Coray, T. A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease. (2025) Nature Medicine. 31(5):1592-1603. DOI: 10.1038/s41591-025-03565-2

Engel, A., Wagner, V., Hahn, O., Foltz, A.G., Atkins, M., Beganovic, A., Guldner, I.H., Lu, N., Saksena, A., Fischer, U., Ludwig, N., Meese, E., Wyss-Coray, T., Keller, A. A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase. (2025) bioRxiv. DOI: 10.1101/2025.03.15.643430

Golomb, S.M., Guldner, I.H., Aleksandrovic, E., Fross, S.R., Liu, X., Diao, L., Liang, K., Wu, J., Wang, Q., Lopez, J.A., Zhang, S. Temporal dynamics of immune cell transcriptomics in brain metastasis progression influenced by gut microbiome dysbiosis. (2025) Cell Reports. 44(3):115356. DOI: 10.1016/j.celrep.2025.115356

Costa, E.K., Chen, J., Guldner, I.H., Mboning, L., Schmahl, N., Tsenter, A., Wu, M.R., Moran-Losada, P., Bouchard, L.S., Wang, S., Singh, P.P., Pellegrini, M., Brunet, A., Wyss-Coray, T. Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish. (2025) bioRxiv. DOI: 10.1101/2025.01.28.635350

Haney, M.S., Pálovics, R., Munson, C.N., Long, C., Johansson, P.K., Yip, O., Dong, W., Rawat, E., West, E., Schlachetzki, J.C.M., Tsai, A., Guldner, I.H., Lamichhane, B.S., Smith, A., Schaum, N., Calcuttawala, K., Shin, A., Wang, Y.H., Wang, C., Koutsodendris, N., Serrano, G.E., Beach, T.G., Reiman, E.M., Glass, C.K., Abu-Remaileh, M., Enejder, A., Huang, Y., Wyss-Coray, T. APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia. (2024) Nature. 628(8006):154-161. DOI: 10.1038/s41586-024-07185-7

Hahn, O., Foltz, A.G., Atkins, M., Kedir, B., Moran-Losada, P., Guldner, I.H., Munson, C., Kern, F., Pálovics, R., Lu, N., Zhang, H., Kaur, A., Hull, J., Huguenard, J.R., Grönke, S., Lehallier, B., Partridge, L., Keller, A., Wyss-Coray, T. Atlas of the aging mouse brain reveals white matter as vulnerable foci. (2023) Cell. 186(19):4117-4133.e22. DOI: 10.1016/j.cell.2023.07.027

Haney, M.S., Pálovics, R., Munson, C.N., Long, C., Johansson, P., Yip, O., Dong, W., Rawat, E., West, E., Schlachetzki, J.C., Tsai, A., Guldner, I.H., Lamichhane, B.S., Smith, A., Schaum, N., Calcuttawala, K., Shin, A., Wang, Y.H., Wang, C., Koutsodendris, N., Serrano, G.E., Beach, T.G., Reiman, E.M., Glass, C.K., Abu-Remaileh, M., Enejder, A., Huang, Y., Wyss-Coray, T. APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia. (2023) bioRxiv. DOI: 10.1101/2023.07.21.549930

Palakurthi, B., Fross, S.R., Guldner, I.H., Aleksandrovic, E., Liu, X., Martino, A.K., Wang, Q., Neff, R.A., Golomb, S.M., Lewis, C., Peng, Y., Howe, E.N., Zhang, S. Targeting CXCL16 and STAT1 augments immune checkpoint blockade therapy in triple-negative breast cancer. (2023) Nature Communications. 14(1):2109. DOI: 10.1038/s41467-023-37727-y

Guldner, I.H.*, Wyss-Coray, T. Activated immune cells drive neurodegeneration in an Alzheimer's model. (2023) Nature. 615(7953):588-589. DOI: 10.1038/d41586-023-00600-5

Zhang, Y., Guldner, I.H., Nichols, E.L., Benirschke, D., Smith, C.J., Zhang, S., Howard, S.S. Instant FLIM enables 4D in vivo lifetime imaging of intact and injured zebrafish and mouse brains. (2021) Optica. 8(6):885-897. DOI: 10.1364/optica.426870

Guldner, I.H.*, Golomb, S.M., Wang, Q., Wang, E., Zhang, S. Isolation of mouse brain-infiltrating leukocytes for single cell profiling of epitopes and transcriptomes. (2021) STAR Protoc. 2(2):100537. DOI: 10.1016/j.xpro.2021.100537

Golomb, S.M., Guldner, I.H., Zhao, A., Wang, Q., Palakurthi, B., Aleksandrovic, E.A., Lopez, J.A., Lee, S.W., Yang, K., Zhang, S. Multi-modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis. (2020) Cell Reports. 33(9):108438. DOI: 10.1016/j.celrep.2020.108438

Guldner, I.H.*, Wang, Q., Yang, L., Golomb, S.M., Zhao, Z., Lopez, J.A., Brunory, A., Howe, E.N., Zhang, Y., Palakurthi, B., Barron, M., Gao, H., Xuei, X., Liu, Y., Li, J., Chen, D.Z., Landreth, G.E., Zhang, S. CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10. (2020) Cell. 183(5):1234-1248.e25. DOI: 10.1016/j.cell.2020.09.064

Howe, E.N., Burnette, M.D., Justice, M.E., Schnepp, P.M., Hedrick, V., Clancy, J.W., Guldner, I.H., Lamere, A.T., Li, J., Aryal, U.K., D'Souza-Schorey, C., Zartman, J.J., Zhang, S. Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth. (2020) Nature Communications. 11(1):3017. DOI: 10.1038/s41467-020-16832-2

Wang, Q., Guldner, I.H., Golomb, S.M., Sun, L., Harris, J.A., Lu, X., Zhang, S. Single-cell profiling guided combinatorial immunotherapy for fast-evolving CDK4/6 inhibitor-resistant HER2-positive breast cancer. (2019) Nature Communications. 10(1):3817. DOI: 10.1038/s41467-019-11729-1

Ni, Y., Schmidt, K.R., Werner, B.A., Koenig, J.K., Guldner, I.H., Schnepp, P.M., Tan, X., Jiang, L., Host, M., Sun, L., Howe, E.N., Wu, J., Littlepage, L.E., Nakshatri, H., Zhang, S. Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer. (2019) Nature Communications. 10(1):2860. DOI: 10.1038/s41467-019-10743-7

Zhang, Y., Nichols, E.L., Zellmer, A.M., Guldner, I.H., Kankel, C., Zhang, S., Howard, S.S., Smith, C.J. Generating intravital super-resolution movies with conventional microscopy reveals actin dynamics that construct pioneer axons. (2019) Development. 146(5). DOI: 10.1242/dev.171512

Schnepp, P.M., Lee, D.D., Guldner, I.H., O'Tighearnaigh, T.K., Howe, E.N., Palakurthi, B., Eckert, K.E., Toni, T.A., Ashfeld, B.L., Zhang, S. GAD1 Upregulation Programs Aggressive Features of Cancer Cell Metabolism in the Brain Metastatic Microenvironment. (2017) Cancer Research. 77(11):2844-2856. DOI: 10.1158/0008-5472.CAN-16-2289

Guldner, I.H.*, Yang, L., Cowdrick, K.R., Wang, Q., Alvarez Barrios, W.V., Zellmer, V.R., Zhang, Y., Host, M., Liu, F., Chen, D.Z., Zhang, S. An Integrative Platform for Three-dimensional Quantitative Analysis of Spatially Heterogeneous Metastasis Landscapes. (2016) Scientific Reports. 6:24201. DOI: 10.1038/srep24201

Guldner, I.H.*, Zhang, S. A journey to uncharted territory: new technical frontiers in studying tumor-stromal cell interactions. (2015) Integr Biol (Camb). 7(2):153-61. DOI: 10.1039/c4ib00192c