Diana Hargreaves

Assistant Professor

Molecular and Cell Biology Laboratory

Richard Heyman and Anne Daigle Endowed Developmental Chair

Salk Institute for Biological Studies - Publications

all Publications


Gao, F., Elliott, N.J., Ho, J., Sharp, A., Shokhirev, M.N., Hargreaves, D.C. Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4. (2019) Molecular Cell. 75(5):891-904. DOI: 10.1016/j.molcel.2019.06.024

+ expand abstract


Hargreaves, D.C. Tuning the chromatin landscape of embryonic stem cells. (2019) Stem Cell Investigation. 6:16. DOI: 10.21037/sci.2019.06.02


Gatchalian, J., Malik, S., Ho, J., Lee, D.S., Kelso, T.W.R., Shokhirev, M.N., Dixon, J.R., Hargreaves, D.C. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. (2018) Nature Communications. 9(1):5139. DOI: 10.1038/s41467-018-07528-9

+ expand abstract


Gatchalian, J., Hargreaves, D.C. Racheting Up Repair. (2018) Immunity. 49(4):577-579. DOI: 10.1016/j.immuni.2018.09.012

+ expand abstract


Marian, C.A., Stoszko, M., Wang, L., Leighty, M.W., de Crignis, E., Maschinot, C.A., Gatchalian, J., Carter, B.C., Chowdhury, B., Hargreaves, D.C., Duvall, J.R., Crabtree, G.R., Mahmoudi, T., Dykhuizen, E.C. Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. (2018) Cell Chemical Biology. DOI: 10.1016/j.chembiol.2018.08.004

+ expand abstract


Kelso, T.W.R., Porter, D.K., Amaral, M.L., Shokhirev, M.N., Benner, C., Hargreaves, D.C. Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. (2017) Elife. 6. DOI: 10.7554/eLife.30506

+ expand abstract


Miller, E.L., Hargreaves, D.C., Kadoch, C., Chang, C.Y., Calarco, J.P., Hodges, C., Buenrostro, J.D., Cui, K., Greenleaf, W.J., Zhao, K., Crabtree, G.R. TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin. (2017) Nature Structural & Molecular Biology. 24(4):344-352. DOI: 10.1038/nsmb.3384

+ expand abstract


Kadoch, C., Hargreaves, D.C., Hodges, C., Elias, L., Ho, L., Ranish, J., Crabtree, G.R. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (2013) Nature Genetics. 45(6):592-601. DOI: 10.1038/ng.2628

+ expand abstract


Dykhuizen, E.C., Hargreaves, D.C., Miller, E.L., Cui, K., Korshunov, A., Kool, M., Pfister, S., Cho, Y.J., Zhao, K., Crabtree, G.R. BAF complexes facilitate decatenation of DNA by topoisomerase IIα. (2013) Nature. 497(7451):624-7. DOI: 10.1038/nature12146

+ expand abstract


Hargreaves, D.C., Horng, T., Medzhitov, R. Control of inducible gene expression by signal-dependent transcriptional elongation. (2009) Cell. 138(1):129-45. DOI: 10.1016/j.cell.2009.05.047

+ expand abstract


Foster, S.L., Hargreaves, D.C., Medzhitov, R. Gene-specific control of inflammation by TLR-induced chromatin modifications. (2007) Nature. 447(7147):972-8. DOI: 10.1038/nature05836

+ expand abstract


Hargreaves, D.C., Medzhitov, R. Innate sensors of microbial infection. (2005) J. Clin. Immunol. 25(6):503-10. DOI: 10.1007/s10875-005-8065-4

+ expand abstract


Luther, S.A., Bidgol, A., Hargreaves, D.C., Schmidt, A., Xu, Y., Paniyadi, J., Matloubian, M., Cyster, J.G. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. (2002) Journal of immunology. 169(1):424-33.

+ expand abstract


Hargreaves, D.C., Hyman, P.L., Lu, T.T., Ngo, V.N., Bidgol, A., Suzuki, G., Zou, Y.R., Littman, D.R., Cyster, J.G. A coordinated change in chemokine responsiveness guides plasma cell movements. (2001) Journal of Experimental Medicine. 194(1):45-56.

+ expand abstract


Education

BS, Haverford College, Chemistry
PhD, Yale University, Immunobiology


Awards & Honors

  • 2019 Pew-Stewart Scholar for Cancer Research
  • 2016-2018 V Foundation Scholar Award, V Foundation for Cancer Research
  • 2014-2018 K99/R00 Pathway to Independence Award, National Cancer Institute/National Institutes of Health
  • 2013-2014 Ann Schreiber Research Training Program of Excellence Grantee, Ovarian Cancer Research Fund
  • 2010-2013 Postdoctoral Fellowship, Helen Hay Whitney Foundation
  • 2002-2005 Graduate Fellowship, National Science Foundation