Diana Hargreaves

Assistant Professor

Molecular and Cell Biology Laboratory

Richard Heyman and Anne Daigle Endowed Developmental Chair

Salk Institute for Biological Studies - Publications

all Publications


Loo, C.S., Gatchalian, J., Liang, Y., Leblanc, M., Xie, M., Ho, J., Venkatraghavan, B., Hargreaves, D.C., Zheng, Y. A Genome-wide CRISPR Screen Reveals a Role for the Non-Canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function. (2020) Immunity. DOI: 10.1016/j.immuni.2020.06.011

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Cortez, J.T., Montauti, E., Shifrut, E., Gatchalian, J., Zhang, Y., Shaked, O., Xu, Y., Roth, T.L., Simeonov, D.R., Zhang, Y., Chen, S., Li, Z., Woo, J.M., Ho, J., Vogel, I.A., Prator, G.Y., Zhang, B., Lee, Y., Sun, Z., Ifergan, I., Van Gool, F., Hargreaves, D.C., Bluestone, J.A., Marson, A., Fang, D. CRISPR screen in regulatory T cells reveals modulators of Foxp3. (2020) Nature. DOI: 10.1038/s41586-020-2246-4

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Gatchalian, J., Liao, J., Maxwell, M.B., Hargreaves, D.C. Control of Stimulus-Dependent Responses in Macrophages by SWI/SNF Chromatin Remodeling Complexes. (2020) Trends in Immunology. DOI: 10.1016/j.it.2019.12.002

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Gao, F., Elliott, N.J., Ho, J., Sharp, A., Shokhirev, M.N., Hargreaves, D.C. Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4. (2019) Molecular Cell. 75(5):891-904. DOI: 10.1016/j.molcel.2019.06.024

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Hargreaves, D.C. Tuning the chromatin landscape of embryonic stem cells. (2019) Stem Cell Investigation. 6:16. DOI: 10.21037/sci.2019.06.02


Gatchalian, J., Malik, S., Ho, J., Lee, D.S., Kelso, T.W.R., Shokhirev, M.N., Dixon, J.R., Hargreaves, D.C. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. (2018) Nature Communications. 9(1):5139. DOI: 10.1038/s41467-018-07528-9

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Gatchalian, J., Hargreaves, D.C. Racheting Up Repair. (2018) Immunity. 49(4):577-579. DOI: 10.1016/j.immuni.2018.09.012

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Marian, C.A., Stoszko, M., Wang, L., Leighty, M.W., de Crignis, E., Maschinot, C.A., Gatchalian, J., Carter, B.C., Chowdhury, B., Hargreaves, D.C., Duvall, J.R., Crabtree, G.R., Mahmoudi, T., Dykhuizen, E.C. Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. (2018) Cell Chemical Biology. DOI: 10.1016/j.chembiol.2018.08.004

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Kelso, T.W.R., Porter, D.K., Amaral, M.L., Shokhirev, M.N., Benner, C., Hargreaves, D.C. Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. (2017) Elife. 6. DOI: 10.7554/eLife.30506

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Miller, E.L., Hargreaves, D.C., Kadoch, C., Chang, C.Y., Calarco, J.P., Hodges, C., Buenrostro, J.D., Cui, K., Greenleaf, W.J., Zhao, K., Crabtree, G.R. TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin. (2017) Nature Structural & Molecular Biology. 24(4):344-352. DOI: 10.1038/nsmb.3384

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Kadoch, C., Hargreaves, D.C., Hodges, C., Elias, L., Ho, L., Ranish, J., Crabtree, G.R. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (2013) Nature Genetics. 45(6):592-601. DOI: 10.1038/ng.2628

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Dykhuizen, E.C., Hargreaves, D.C., Miller, E.L., Cui, K., Korshunov, A., Kool, M., Pfister, S., Cho, Y.J., Zhao, K., Crabtree, G.R. BAF complexes facilitate decatenation of DNA by topoisomerase IIα. (2013) Nature. 497(7451):624-7. DOI: 10.1038/nature12146

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Hargreaves, D.C., Crabtree, G.R. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. (2011) Cell Research. 21(3):396-420. DOI: 10.1038/cr.2011.32

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Hargreaves, D.C., Horng, T., Medzhitov, R. Control of inducible gene expression by signal-dependent transcriptional elongation. (2009) Cell. 138(1):129-45. DOI: 10.1016/j.cell.2009.05.047

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Foster, S.L., Hargreaves, D.C., Medzhitov, R. Gene-specific control of inflammation by TLR-induced chromatin modifications. (2007) Nature. 447(7147):972-8. DOI: 10.1038/nature05836

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Hargreaves, D.C., Medzhitov, R. Innate sensors of microbial infection. (2005) J. Clin. Immunol. 25(6):503-10. DOI: 10.1007/s10875-005-8065-4

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Luther, S.A., Bidgol, A., Hargreaves, D.C., Schmidt, A., Xu, Y., Paniyadi, J., Matloubian, M., Cyster, J.G. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. (2002) Journal of immunology. 169(1):424-33.

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Cyster, J.G., Ansel, K.M., Ngo, V.N., Hargreaves, D.C., Lu, T.T. Traffic patterns of B cells and plasma cells. (2002) Advances in Experimental Medicine and Biology. 512:35-41.


Hargreaves, D.C., Hyman, P.L., Lu, T.T., Ngo, V.N., Bidgol, A., Suzuki, G., Zou, Y.R., Littman, D.R., Cyster, J.G. A coordinated change in chemokine responsiveness guides plasma cell movements. (2001) Journal of Experimental Medicine. 194(1):45-56.

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Education

BS, Chemistry and Biochemistry, Haverford College
PhD, Department of Immunobiology, Yale University
Postdoctoral Fellowship, Department of Developmental Biology, Stanford University


Awards & Honors

  • Pew-Stewart Scholar for Cancer Research, 2019
  • V Foundation for Cancer Research, V Foundation Scholar Award, 2016-2018
  • NCI/NIH K99/R00 Pathway to Independence Award, 2014-2018
  • Ovarian Cancer Research Fund, Ann Schreiber Research Training Program of Excellence, 2013-2014
  • Helen Hay Whitney Foundation Postdoctoral Fellowship, 2010-2013
  • National Science Foundation Graduate Research Fellowship, 2002-2005