Diana Hargreaves

Assistant Professor

Molecular and Cell Biology Laboratory

Richard Heyman and Anne Daigle Endowed Development Chair

Salk Institute for Biological Studies - Publications

all Publications


Kelso, T.W.R., Porter, D.K., Amaral, M.L., Shokhirev, M.N., Benner, C., Hargreaves, D.C. Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. (2017) Elife. 6. DOI: 10.7554/eLife.30506

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Miller, E.L., Hargreaves, D.C., Kadoch, C., Chang, C.Y., Calarco, J.P., Hodges, C., Buenrostro, J.D., Cui, K., Greenleaf, W.J., Zhao, K., Crabtree, G.R. TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin. (2017) Nat. Struct. Mol. Biol. 24(4):344-352. DOI: 10.1038/nsmb.3384

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Kadoch, C., Hargreaves, D.C., Hodges, C., Elias, L., Ho, L., Ranish, J., Crabtree, G.R. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (2013) Nat. Genet. 45(6):592-601. DOI: 10.1038/ng.2628

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Dykhuizen, E.C., Hargreaves, D.C., Miller, E.L., Cui, K., Korshunov, A., Kool, M., Pfister, S., Cho, Y.J., Zhao, K., Crabtree, G.R. BAF complexes facilitate decatenation of DNA by topoisomerase IIα. (2013) Nature. 497(7451):624-7. DOI: 10.1038/nature12146

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Hargreaves, D.C., Horng, T., Medzhitov, R. Control of inducible gene expression by signal-dependent transcriptional elongation. (2009) Cell. 138(1):129-45. DOI: 10.1016/j.cell.2009.05.047

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Foster, S.L., Hargreaves, D.C., Medzhitov, R. Gene-specific control of inflammation by TLR-induced chromatin modifications. (2007) Nature. 447(7147):972-8. DOI: 10.1038/nature05836

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Hargreaves, D.C., Medzhitov, R. Innate sensors of microbial infection. (2005) J. Clin. Immunol. 25(6):503-10. DOI: 10.1007/s10875-005-8065-4

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Luther, S.A., Bidgol, A., Hargreaves, D.C., Schmidt, A., Xu, Y., Paniyadi, J., Matloubian, M., Cyster, J.G. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. (2002) J. Immunol. 169(1):424-33.

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Hargreaves, D.C., Hyman, P.L., Lu, T.T., Ngo, V.N., Bidgol, A., Suzuki, G., Zou, Y.R., Littman, D.R., Cyster, J.G. A coordinated change in chemokine responsiveness guides plasma cell movements. (2001) J. Exp. Med. 194(1):45-56.

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Education

BS, Haverford College, Chemistry 2000
PhD, Yale University, Immunobiology 2009


Awards & Honors

  • 2013-2014 Ann Schreiber Research Training Program of Excellence Grantee, Ovarian Cancer Research Fund
  • 2010-2013 Postdoctoral Fellowship, Helen Hay Whitney Foundation
  • 2002-2005 Graduate Fellowship, National Science Foundation