Metabolism

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Salk Institute for Biological Studies - Metabolism - Videos

Videos


Salk scientists modify CRISPR to epigenetically treat diabetes, kidney disease, muscular dystrophy

LA JOLLA—Salk scientists have created a new version of the CRISPR/Cas9 genome editing technology that allows them to activate genes without creating breaks in the DNA, potentially circumventing a major hurdle to using gene editing technologies to treat human diseases. Read more »


“Exercise-in-a-pill” boosts athletic endurance by 70 percent

Every week, there seems to be another story about the health benefits of running. That’s great—but what if you can’t run? For the elderly, obese or otherwise mobility-limited, the rewards of aerobic exercise have long been out of reach.
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Salk scientists find “secret sauce” for personalized, functional insulin-producing cells

Salk scientists have solved a longstanding problem in the effort to create replacement cells for diabetic patients. The team uncovered a hidden energy switch that, when flipped, powers up pancreatic cells to respond to glucose, a step that eluded previous research. The result is the production of hundreds of millions of lab-produced human beta cells—able to relieve diabetes in mice. Read More »


Blocking immune cell treats new type of age-related diabetes

Diabetes is often the result of obesity and poor diet choices, but for some older adults the disease might simply be a consequence of aging. New research has discovered that diabetes—or insulin resistance—in aged, lean mice has a different cellular cause than the diabetes that results from weight gain (type 2). And the findings point toward a possible cure for what the co-leading scientists, Ronald Evans and Ye Zheng, are now calling a new kind of diabetes (type 4).
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App Fights “Metabolic Jet Lag” to Improve Health

Salk scientists show how timed feeding could help fight “metabolic jetlag”

Breakfast, lunch and dinner? For too many of us, the three meals of the day go more like: morning meeting pastry, mid-afternoon energy drink and midnight pizza. In <em>Cell Metabolism</em> on September 24, Salk Institute scientists present daily food and beverage intake data collected from over 150 participants of a mobile research app over three weeks. They show that a majority of people eat for 15 hours or longer, with less than a quarter of the day’s calories being consumed before noon and over a third consumed after 6 p.m. Read more »