LA JOLLA—At noon every day, levels of genes and proteins throughout your body are drastically different than they are at midnight. Disruptions to this 24-hour cycle of physiological activity are why jet lag or a bad night’s sleep can alter your appetite and sleep patterns for days—and even contribute to conditions like heart disease, sleep disorders and cancers.
LA JOLLA—A new technique developed by Salk Institute scientists for rapidly mapping regions of DNA targeted by regulatory proteins could give scientists insight into what makes some plants drought tolerant or disease resistant, among other traits.
LA JOLLA—A molecular pathway that is activated in the brain during fasting helps halt the spread of intestinal bacteria into the bloodstream, according to a new study by a team of researchers at the Salk Institute.
LA JOLLA—When tweaking its architecture, the adult brain works like a sculptor—starting with more than it needs so it can carve away the excess to achieve the perfect design. That’s the conclusion of a new study that tracked developing cells in an adult mouse brain in real time.
LA JOLLA–Four Salk Institute faculty members have been promoted after the latest round of faculty reviews determined they are scientific leaders who have made original, innovative and notable contributions to biological research.
LA JOLLA—A microscope about the size of a penny is giving scientists a new window into the everyday activity of cells within the spinal cord. The innovative technology revealed that astrocytes—cells in the nervous system that do not conduct electrical signals and were traditionally viewed as merely supportive—unexpectedly react to intense sensation.
LA JOLLA—Salk Institute scientists showed how an FDA-approved drug boosts the health of brain cells by limiting their energy use. Like removing unnecessary lighting from a financially strapped household to save on electricity bills, the drug—called rapamycin—prolongs the survival of diseased neurons by forcing them to reduce protein production to conserve cellular energy.
LA JOLLA—(April 25, 2016) Salk scientists have revealed how a cellular “fuel gauge” responsible for monitoring and managing cells’ energy processes also has an unexpected role in development. This critical link could help researchers better understand cancer and diabetes pathways.
LA JOLLA—Broadening its expertise in neuroscience, the Salk Institute is pleased to announce the appointment of Eiman Azim as an assistant professor in the Molecular Neurobiology Laboratory. He will join the Institute in May.
LA JOLLA-The Salk Institute awarded two American scientists with its prestigious Medal for Research Excellence, a distinction that has only been bestowed twice before in the Institute’s 55-year history. The honorees, who received their awards April 13, independently addressed the Salk community in presentations prior to an awards reception.
LA JOLLA—Salk Institute scientists have developed a new reagent to map the brain’s complex network of connections that is 20 times more efficient than their previous version. This tool improves upon a technique called rabies virus tracing, which was originally developed in the Callaway lab at Salk and is commonly used to map neural connections.
LA JOLLA—Salk scientists have solved a longstanding problem in the effort to create replacement cells for diabetic patients. The team uncovered a hidden energy switch that, when flipped, powers up pancreatic cells to respond to glucose, a step that eluded previous research. The result is the production of hundreds of millions of lab-produced human beta cells—able to relieve diabetes in mice.
LA JOLLA—By adolescence, your brain already contains most of the neurons that you’ll have for the rest of your life. But a few regions continue to grow new nerve cells—and require the services of cellular sentinels, specialized immune cells that keep the brain safe by getting rid of dead or dysfunctional cells.
LA JOLLA—A team led by scientists at The Scripps Research Institute (TSRI) and the Salk Institute for Biological Studies has discovered two enzymes that appear to play a role in metabolism and inflammation—and might someday be targeted with drugs to treat type 2 diabetes and inflammatory disorders.
LA JOLLA—Distinguished Salk Institute Professor Rusty Gage is one of four new members to be elected to the National Academy of Sciences (NAS) Governing Council. Gage is a professor in Salk’s Laboratory of Genetics and holds the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease.
The Salk Institute will open its doors to the public Saturday, April 16 for the fourth annual Explore Salk, the Institute’s once-a-year community open house. In addition to guided lab tours and science booths, this year’s event features a talk by Salk’s new president, Nobel laureate Dr. Elizabeth Blackburn, titled “Don’t Cell Yourself Short.”
LA JOLLA—Using cutting-edge imaging technology, Salk Institute and Harvard Medical School researchers have determined the structure of a protein complex that lets viruses similar to the human immunodeficiency virus (HIV) establish permanent infections within their hosts.
LA JOLLA—When you stare in puzzlement at an optical illusion, two distinct parts of the neocortex in your brain are hard at work: the primary visual cortex is receiving information on what your eyes see, and the surrounding higher order visual areas are trying to interpret that tricky amalgam of information. These two areas, though, are linked in more ways than just function—the same gene controls the size of each area, Salk researchers led by Dennis O’Leary have now discovered.
LA JOLLA—Salk researchers and collaborators have achieved critical insight into the size of neural connections, putting the memory capacity of the brain far higher than common estimates. The new work also answers a longstanding question as to how the brain is so energy efficient and could help engineers build computers that are incredibly powerful but also conserve energy.