Jan Karlseder

Professor

Molecular and Cell Biology Laboratory

Donald and Darlene Shiley Chair

Salk Institute for Biological Studies - Publications

all Publications


Masamsetti, V.P., Low, R.R.J., Mak, K.S., O'Connor, A., Riffkin, C.D., Lamm, N., Crabbe, L., Karlseder, J., Huang, D.C.S., Hayashi, M.T., Cesare, A.J. Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection. (2019) Nature Communications. 10(1):4224. DOI: 10.1038/s41467-019-12255-w

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Nassour, J., Radford, R., Correia, A., Fusté, J.M., Schoell, B., Jauch, A., Shaw, R.J., Karlseder, J. Autophagic cell death restricts chromosomal instability during replicative crisis. (2019) Nature. 565(7741):659-663. DOI: 10.1038/s41586-019-0885-0

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Arnoult, N., Correia, A., Ma, J., Merlo, A., Garcia-Gomez, S., Maric, M., Tognetti, M., Benner, C.W., Boulton, S.J., Saghatelian, A., Karlseder, J. Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN. (2017) Nature. 549(7673):548-552. DOI: 10.1038/nature24023

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Li, J.S., Miralles Fusté, J., Simavorian, T., Bartocci, C., Tsai, J., Karlseder, J., Lazzerini Denchi, E. TZAP: A telomere-associated protein involved in telomere length control. (2017) Science. 355(6325):638-641. DOI: 10.1126/science.aah6752

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Rivera, T., Haggblom, C., Cosconati, S., Karlseder, J. A balance between elongation and trimming regulates telomere stability in stem cells. (2017) Nature Structural & Molecular Biology. 24(1):30-39. DOI: 10.1038/nsmb.3335

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Arnoult, N., Karlseder, J. Complex interactions between the DNA-damage response and mammalian telomeres. (2015) Nature Structural & Molecular Biology. 22(11):859-66. DOI: 10.1038/nsmb.3092

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Hayashi, M.T., Cesare, A.J., Rivera, T., Karlseder, J. Cell death during crisis is mediated by mitotic telomere deprotection. (2015) Nature. 522(7557):492-6. DOI: 10.1038/nature14513

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Lackner, D.H., Hayashi, M.T., Cesare, A.J., Karlseder, J. A genomics approach identifies senescence-specific gene expression regulation. (2014) Aging Cell. 13(5):946-50. DOI: 10.1111/acel.12234

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Arnoult, N., Karlseder, J. ALT telomeres borrow from meiosis to get moving. (2014) Cell. 159(1):11-2. DOI: 10.1016/j.cell.2014.09.013

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Karlseder, J. Modern genome editing meets telomeres: the many functions of TPP1. (2014) Genes & Development. 28(17):1857-8. DOI: 10.1101/gad.250316.114

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O'Sullivan, R.J., Arnoult, N., Lackner, D.H., Oganesian, L., Haggblom, C., Corpet, A., Almouzni, G., Karlseder, J. Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. (2014) Nature Structural & Molecular Biology. 21(2):167-74. DOI: 10.1038/nsmb.2754

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Hayashi, M.T., Karlseder, J. DNA damage associated with mitosis and cytokinesis failure. (2013) Oncogene. 32(39):4593-601. DOI: 10.1038/onc.2012.615

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Cesare, A.J., Hayashi, M.T., Crabbe, L., Karlseder, J. The telomere deprotection response is functionally distinct from the genomic DNA damage response. (2013) Molecular Cell. 51(2):141-55. DOI: 10.1016/j.molcel.2013.06.006

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Oganesian, L., Karlseder, J. 5' C-rich telomeric overhangs are an outcome of rapid telomere truncation events. (2013) DNA Repair (Amst.). 12(3):238-45. DOI: 10.1016/j.dnarep.2012.12.008

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Lackner, D.H., Karlseder, J. C. elegans survivors without telomerase. (2013) Worm. 2(1):e21073. DOI: 10.4161/worm.21073

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Crabbe, L., Cesare, A.J., Kasuboski, J.M., Fitzpatrick, J.A., Karlseder, J. Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly. (2012) Cell Reports. 2(6):1521-9. DOI: 10.1016/j.celrep.2012.11.019

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Cesare, A.J., Karlseder, J. A three-state model of telomere control over human proliferative boundaries. (2012) Current Opinion in Cell Biology. 24(6):731-8. DOI: 10.1016/j.ceb.2012.08.007

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O'Sullivan, R.J., Karlseder, J. The great unravelling: chromatin as a modulator of the aging process. (2012) Trends in Biochemical Sciences. 37(11):466-76. DOI: 10.1016/j.tibs.2012.08.001

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Barefield, C., Karlseder, J. The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures. (2012) Nucleic Acids Research. 40(15):7358-67. DOI: 10.1093/nar/gks407

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Lackner, D.H., Raices, M., Maruyama, H., Haggblom, C., Karlseder, J. Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans. (2012) EMBO Journal. 31(8):2024-33. DOI: 10.1038/emboj.2012.61

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Hayashi, M.T., Cesare, A.J., Fitzpatrick, J.A., Lazzerini-Denchi, E., Karlseder, J. A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest. (2012) Nature Structural & Molecular Biology. 19(4):387-94. DOI: 10.1038/nsmb.2245

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Lackner, D.H., Durocher, D., Karlseder, J. A siRNA-based screen for genes involved in chromosome end protection. (2011) PLOS One. 6(6):e21407. DOI: 10.1371/journal.pone.0021407

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Oganesian, L., Karlseder, J. Mammalian 5' C-rich telomeric overhangs are a mark of recombination-dependent telomere maintenance. (2011) Molecular Cell. 42(2):224-36. DOI: 10.1016/j.molcel.2011.03.015

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Flynn, R.L., Centore, R.C., O'Sullivan, R.J., Rai, R., Tse, A., Songyang, Z., Chang, S., Karlseder, J., Zou, L. TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. (2011) Nature. 471(7339):532-6. DOI: 10.1038/nature09772

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Orazio, N.I., Naeger, C.M., Karlseder, J., Weitzman, M.D. The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection. (2011) Journal of Virology. 85(4):1887-92. DOI: 10.1128/JVI.02134-10

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Corpet, A., De Koning, L., Toedling, J., Savignoni, A., Berger, F., Lemaître, C., O'Sullivan, R.J., Karlseder, J., Barillot, E., Asselain, B., Sastre-Garau, X., Almouzni, G. Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer. (2011) EMBO Journal. 30(3):480-93. DOI: 10.1038/emboj.2010.335

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O'Sullivan, R.J., Kubicek, S., Schreiber, S.L., Karlseder, J. Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. (2010) Nature Structural & Molecular Biology. 17(10):1218-25. DOI: 10.1038/nsmb.1897

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Crabbe, L., Karlseder, J. Mammalian Rap1 widens its impact. (2010) Nature Cell Biology. 12(8):733-5. DOI: 10.1038/ncb2088


O'Sullivan, R.J., Karlseder, J. Telomeres: protecting chromosomes against genome instability. (2010) Nature Reviews. Molecular Cell Biology. 11(3):171-81. DOI: 10.1038/nrm2848

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Blagosklonny, M.V., Campisi, J., Sinclair, D.A., Bartke, A., Blasco, M.A., Bonner, W.M., Bohr, V.A., Brosh, R.M., Brunet, A., Depinho, R.A., Donehower, L.A., Finch, C.E., Finkel, T., Gorospe, M., Gudkov, A.V., Hall, M.N., Hekimi, S., Helfand, S.L., Karlseder, J., Kenyon, C., Kroemer, G., Longo, V., Nussenzweig, A., Osiewacz, H.D., Peeper, D.S., Rando, T.A., Rudolph, K.L., Sassone-Corsi, P., Serrano, M., Sharpless, N.E., Skulachev, V.P., Tilly, J.L., Tower, J., Verdin, E., Vijg, J. Impact papers on aging in 2009. (2010) Aging. 2(3):111-21. DOI: 10.18632/aging.100132

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Karlseder, J. Chromosome end protection becomes even more complex. (2009) Nature Structural & Molecular Biology. 16(12):1205-6. DOI: 10.1038/nsmb1209-1205


Oganesian, L., Karlseder, J. Telomeric armor: the layers of end protection. (2009) Journal of Cell Science. 122(Pt 22):4013-25. DOI: 10.1242/jcs.050567

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Sfeir, A., Kosiyatrakul, S.T., Hockemeyer, D., MacRae, S.L., Karlseder, J., Schildkraut, C.L., de Lange, T. Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. (2009) Cell. 138(1):90-103. DOI: 10.1016/j.cell.2009.06.021

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Begemann, S., Galimi, F., Karlseder, J. Moderate expression of TRF2 in the hematopoietic system increases development of large cell blastic T-cell lymphomas. (2009) Aging. 1(1):122-130. DOI: 10.18632/aging.100015

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Raices, M., Verdun, R.E., Compton, S.A., Haggblom, C.I., Griffith, J.D., Dillin, A., Karlseder, J. C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. (2008) Cell. 132(5):745-57. DOI: 10.1016/j.cell.2007.12.039

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Verdun, R.E., Karlseder, J. Replication and protection of telomeres. (2007) Nature. 447(7147):924-31. DOI: 10.1038/nature05976

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Karlseder, J., Cooper, J.P. Of wombats and whales: telomere tales in Madrid. Conference on telomeres and telomerase. (2007) EMBO Reports. 8(6):542-6. DOI: 10.1038/sj.embor.7400985


Crabbe, L., Jauch, A., Naeger, C.M., Holtgreve-Grez, H., Karlseder, J. Telomere dysfunction as a cause of genomic instability in Werner syndrome. (2007) Proceedings of the National Academy of Sciences of the United States of America. 104(7):2205-10. DOI: 10.1073/pnas.0609410104

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Verdun, R.E., Karlseder, J. The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. (2006) Cell. 127(4):709-20. DOI: 10.1016/j.cell.2006.09.034

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Karlseder, J. Telomeric proteins: clearing the way for the replication fork. (2006) Nature Structural & Molecular Biology. 13(5):386-7. DOI: 10.1038/nsmb0506-386

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Verdun, R.E., Crabbe, L., Haggblom, C., Karlseder, J. Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. (2005) Molecular Cell. 20(4):551-61. DOI: 10.1016/j.molcel.2005.09.024

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Raices, M., Maruyama, H., Dillin, A., Karlseder, J. Uncoupling of longevity and telomere length in C. elegans. (2005) PLOS Genetics. 1(3):e30. DOI: 10.1371/journal.pgen.0010030

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Crabbe, L., Karlseder, J. In the end, it's all structure. (2005) Current Molecular Medicine. 5(2):135-43.

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Crabbe, L., Verdun, R.E., Haggblom, C.I., Karlseder, J. Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. (2004) Science. 306(5703):1951-3. DOI: 10.1126/science.1103619

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Karlseder, J., Hoke, K., Mirzoeva, O.K., Bakkenist, C., Kastan, M.B., Petrini, J.H., de Lange, T. The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. (2004) PLOS Biology. 2(8):E240. DOI: 10.1371/journal.pbio.0020240

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Karlseder, J., Kachatrian, L., Takai, H., Mercer, K., Hingorani, S., Jacks, T., de Lange, T. Targeted deletion reveals an essential function for the telomere length regulator Trf1. (2003) Molecular and Cellular Biology. 23(18):6533-41.

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Karlseder, J. Telomere repeat binding factors: keeping the ends in check. (2003) Cancer Letters. 194(2):189-97.

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Smogorzewska, A., Karlseder, J., Holtgreve-Grez, H., Jauch, A., de Lange, T. DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. (2002) Current Biology. 12(19):1635-44.

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Karlseder, J., Smogorzewska, A., de Lange, T. Senescence induced by altered telomere state, not telomere loss. (2002) Science. 295(5564):2446-9. DOI: 10.1126/science.1069523

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Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., de Lange, T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. (1999) Science. 283(5406):1321-5.

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Wolschek, M.F., Narendja, F., Karlseder, J., Kubicek, C.P., Scazzocchio, C., Strauss, J. In situ detection of protein-DNA interactions in filamentous fungi by in vivo footprinting. (1998) Nucleic Acids Research. 26(16):3862-4.

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Sliutz, G., Karlseder, J., Tempfer, C., Orel, L., Holzer, G., Simon, M.M. Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy. (1996) British Journal of Cancer. 74(2):172-7.

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Sutterluety, H., Bartl, S., Karlseder, J., Wintersberger, E., Seiser, C. Carboxy-terminal residues of mouse thymidine kinase are essential for rapid degradation in quiescent cells. (1996) Journal of Molecular Biology. 259(3):383-92. DOI: 10.1006/jmbi.1996.0327

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Karlseder, J., Rotheneder, H., Wintersberger, E. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. (1996) Molecular and Cellular Biology. 16(4):1659-67.

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Karlseder, J., Wissing, D., Holzer, G., Orel, L., Sliutz, G., Auer, H., Jäättelä, M., Simon, M.M. HSP70 overexpression mediates the escape of a doxorubicin-induced G2 cell cycle arrest. (1996) Biochemical and Biophysical Research Communications. 220(1):153-9. DOI: 10.1006/bbrc.1996.0373

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Karlseder, J., Zeillinger, R., Schneeberger, C., Czerwenka, K., Speiser, P., Kubista, E., Birnbaum, D., Gaudray, P., Theillet, C. Patterns of DNA amplification at band q13 of chromosome 11 in human breast cancer. (1994) Genes Chromosomes Cancer. 9(1):42-8.

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Education

BS, Biology, University of Innsbruck, Austria
PhD, Molecular Biology, University of Vienna
Postdoctoral Fellowship, The Rockefeller University, NY


Awards & Honors

  • Glenn Award for Research in Biological Mechanisms of Aging, 2009
  • Forbeck Scholar Award, 2002
  • The V Foundation Award for Developing Scientists, 2002
  • Charles H. Revson Fellowship, 1999
  • Human Frontiers Science Program Fellowship, 1997
  • European Molecular Biology Organization Fellowship, 1993