Jan Karlseder

Professor

Molecular and Cell Biology Laboratory

Donald and Darlene Shiley Chair

Salk Institute for Biological Studies - Publications

all Publications


Arnoult, N., Correia, A., Ma, J., Merlo, A., Garcia-Gomez, S., Maric, M., Tognetti, M., Benner, C.W., Boulton, S.J., Saghatelian, A., Karlseder, J. Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN. (2017) Nature. 549(7673):548-552. DOI: 10.1038/nature24023

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Li, J.S., Miralles Fusté, J., Simavorian, T., Bartocci, C., Tsai, J., Karlseder, J., Lazzerini Denchi, E. TZAP: A telomere-associated protein involved in telomere length control. (2017) Science. 355(6325):638-641. DOI: 10.1126/science.aah6752

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Rivera, T., Haggblom, C., Cosconati, S., Karlseder, J. A balance between elongation and trimming regulates telomere stability in stem cells. (2017) Nat. Struct. Mol. Biol. 24(1):30-39. DOI: 10.1038/nsmb.3335

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Arnoult, N., Karlseder, J. Complex interactions between the DNA-damage response and mammalian telomeres. (2015) Nat. Struct. Mol. Biol. 22(11):859-66. DOI: 10.1038/nsmb.3092

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Hayashi, M.T., Cesare, A.J., Rivera, T., Karlseder, J. Cell death during crisis is mediated by mitotic telomere deprotection. (2015) Nature. 522(7557):492-6. DOI: 10.1038/nature14513

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Lackner, D.H., Hayashi, M.T., Cesare, A.J., Karlseder, J. A genomics approach identifies senescence-specific gene expression regulation. (2014) Aging Cell. 13(5):946-50. DOI: 10.1111/acel.12234

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Arnoult, N., Karlseder, J. ALT telomeres borrow from meiosis to get moving. (2014) Cell. 159(1):11-2. DOI: 10.1016/j.cell.2014.09.013

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Karlseder, J. Modern genome editing meets telomeres: the many functions of TPP1. (2014) Genes Dev. 28(17):1857-8. DOI: 10.1101/gad.250316.114

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O'Sullivan, R.J., Arnoult, N., Lackner, D.H., Oganesian, L., Haggblom, C., Corpet, A., Almouzni, G., Karlseder, J. Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. (2014) Nat. Struct. Mol. Biol. 21(2):167-74. DOI: 10.1038/nsmb.2754

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Hayashi, M.T., Karlseder, J. DNA damage associated with mitosis and cytokinesis failure. (2013) Oncogene. 32(39):4593-601. DOI: 10.1038/onc.2012.615

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Cesare, A.J., Hayashi, M.T., Crabbe, L., Karlseder, J. The telomere deprotection response is functionally distinct from the genomic DNA damage response. (2013) Mol. Cell. 51(2):141-55. DOI: 10.1016/j.molcel.2013.06.006

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Oganesian, L., Karlseder, J. 5' C-rich telomeric overhangs are an outcome of rapid telomere truncation events. (2013) DNA Repair (Amst.). 12(3):238-45. DOI: 10.1016/j.dnarep.2012.12.008

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Lackner, D.H., Karlseder, J. C. elegans survivors without telomerase. (2013) Worm. 2(1):e21073. DOI: 10.4161/worm.21073

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Crabbe, L., Cesare, A.J., Kasuboski, J.M., Fitzpatrick, J.A., Karlseder, J. Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly. (2012) Cell Rep. 2(6):1521-9. DOI: 10.1016/j.celrep.2012.11.019

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Cesare, A.J., Karlseder, J. A three-state model of telomere control over human proliferative boundaries. (2012) Curr. Opin. Cell Biol. 24(6):731-8. DOI: 10.1016/j.ceb.2012.08.007

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O'Sullivan, R.J., Karlseder, J. The great unravelling: chromatin as a modulator of the aging process. (2012) Trends Biochem. Sci. 37(11):466-76. DOI: 10.1016/j.tibs.2012.08.001

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Barefield, C., Karlseder, J. The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures. (2012) Nucleic Acids Res. 40(15):7358-67. DOI: 10.1093/nar/gks407

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Lackner, D.H., Raices, M., Maruyama, H., Haggblom, C., Karlseder, J. Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans. (2012) EMBO J. 31(8):2024-33. DOI: 10.1038/emboj.2012.61

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Hayashi, M.T., Cesare, A.J., Fitzpatrick, J.A., Lazzerini-Denchi, E., Karlseder, J. A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest. (2012) Nat. Struct. Mol. Biol. 19(4):387-94. DOI: 10.1038/nsmb.2245

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Lackner, D.H., Durocher, D., Karlseder, J. A siRNA-based screen for genes involved in chromosome end protection. (2011) PLoS ONE. 6(6):e21407. DOI: 10.1371/journal.pone.0021407

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Oganesian, L., Karlseder, J. Mammalian 5' C-rich telomeric overhangs are a mark of recombination-dependent telomere maintenance. (2011) Mol. Cell. 42(2):224-36. DOI: 10.1016/j.molcel.2011.03.015

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Flynn, R.L., Centore, R.C., O'Sullivan, R.J., Rai, R., Tse, A., Songyang, Z., Chang, S., Karlseder, J., Zou, L. TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. (2011) Nature. 471(7339):532-6. DOI: 10.1038/nature09772

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Orazio, N.I., Naeger, C.M., Karlseder, J., Weitzman, M.D. The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection. (2011) J. Virol. 85(4):1887-92. DOI: 10.1128/JVI.02134-10

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Corpet, A., De Koning, L., Toedling, J., Savignoni, A., Berger, F., Lemaître, C., O'Sullivan, R.J., Karlseder, J., Barillot, E., Asselain, B., Sastre-Garau, X., Almouzni, G. Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer. (2011) EMBO J. 30(3):480-93. DOI: 10.1038/emboj.2010.335

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O'Sullivan, R.J., Kubicek, S., Schreiber, S.L., Karlseder, J. Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. (2010) Nat. Struct. Mol. Biol. 17(10):1218-25. DOI: 10.1038/nsmb.1897

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Crabbe, L., Karlseder, J. Mammalian Rap1 widens its impact. (2010) Nat. Cell Biol. 12(8):733-5. DOI: 10.1038/ncb2088


O'Sullivan, R.J., Karlseder, J. Telomeres: protecting chromosomes against genome instability. (2010) Nat. Rev. Mol. Cell Biol. 11(3):171-81. DOI: 10.1038/nrm2848

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Blagosklonny, M.V., Campisi, J., Sinclair, D.A., Bartke, A., Blasco, M.A., Bonner, W.M., Bohr, V.A., Brosh, R.M., Brunet, A., Depinho, R.A., Donehower, L.A., Finch, C.E., Finkel, T., Gorospe, M., Gudkov, A.V., Hall, M.N., Hekimi, S., Helfand, S.L., Karlseder, J., Kenyon, C., Kroemer, G., Longo, V., Nussenzweig, A., Osiewacz, H.D., Peeper, D.S., Rando, T.A., Rudolph, K.L., Sassone-Corsi, P., Serrano, M., Sharpless, N.E., Skulachev, V.P., Tilly, J.L., Tower, J., Verdin, E., Vijg, J. Impact papers on aging in 2009. (2010) Aging (Albany NY). 2(3):111-21. DOI: 10.18632/aging.100132

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Karlseder, J. Chromosome end protection becomes even more complex. (2009) Nat. Struct. Mol. Biol. 16(12):1205-6. DOI: 10.1038/nsmb1209-1205


Oganesian, L., Karlseder, J. Telomeric armor: the layers of end protection. (2009) J. Cell. Sci. 122(Pt 22):4013-25. DOI: 10.1242/jcs.050567

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Sfeir, A., Kosiyatrakul, S.T., Hockemeyer, D., MacRae, S.L., Karlseder, J., Schildkraut, C.L., de Lange, T. Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. (2009) Cell. 138(1):90-103. DOI: 10.1016/j.cell.2009.06.021

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Begemann, S., Galimi, F., Karlseder, J. Moderate expression of TRF2 in the hematopoietic system increases development of large cell blastic T-cell lymphomas. (2009) Aging (Albany NY). 1(1):122-130. DOI: 10.18632/aging.100015

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Raices, M., Verdun, R.E., Compton, S.A., Haggblom, C.I., Griffith, J.D., Dillin, A., Karlseder, J. C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. (2008) Cell. 132(5):745-57. DOI: 10.1016/j.cell.2007.12.039

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Verdun, R.E., Karlseder, J. Replication and protection of telomeres. (2007) Nature. 447(7147):924-31. DOI: 10.1038/nature05976

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Karlseder, J., Cooper, J.P. Of wombats and whales: telomere tales in Madrid. Conference on telomeres and telomerase. (2007) EMBO Rep. 8(6):542-6. DOI: 10.1038/sj.embor.7400985


Crabbe, L., Jauch, A., Naeger, C.M., Holtgreve-Grez, H., Karlseder, J. Telomere dysfunction as a cause of genomic instability in Werner syndrome. (2007) Proc. Natl. Acad. Sci. U.S.A. 104(7):2205-10. DOI: 10.1073/pnas.0609410104

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Verdun, R.E., Karlseder, J. The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. (2006) Cell. 127(4):709-20. DOI: 10.1016/j.cell.2006.09.034

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Karlseder, J. Telomeric proteins: clearing the way for the replication fork. (2006) Nat. Struct. Mol. Biol. 13(5):386-7. DOI: 10.1038/nsmb0506-386

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Verdun, R.E., Crabbe, L., Haggblom, C., Karlseder, J. Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. (2005) Mol. Cell. 20(4):551-61. DOI: 10.1016/j.molcel.2005.09.024

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Raices, M., Maruyama, H., Dillin, A., Karlseder, J. Uncoupling of longevity and telomere length in C. elegans. (2005) PLoS Genet. 1(3):e30. DOI: 10.1371/journal.pgen.0010030

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Crabbe, L., Karlseder, J. In the end, it's all structure. (2005) Curr. Mol. Med. 5(2):135-43.

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Crabbe, L., Verdun, R.E., Haggblom, C.I., Karlseder, J. Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. (2004) Science. 306(5703):1951-3. DOI: 10.1126/science.1103619

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Karlseder, J., Hoke, K., Mirzoeva, O.K., Bakkenist, C., Kastan, M.B., Petrini, J.H., de Lange, T. The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. (2004) PLoS Biol. 2(8):E240. DOI: 10.1371/journal.pbio.0020240

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Karlseder, J., Kachatrian, L., Takai, H., Mercer, K., Hingorani, S., Jacks, T., de Lange, T. Targeted deletion reveals an essential function for the telomere length regulator Trf1. (2003) Mol. Cell. Biol. 23(18):6533-41.

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Karlseder, J. Telomere repeat binding factors: keeping the ends in check. (2003) Cancer Lett. 194(2):189-97.

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Smogorzewska, A., Karlseder, J., Holtgreve-Grez, H., Jauch, A., de Lange, T. DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. (2002) Curr. Biol. 12(19):1635-44.

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Karlseder, J., Smogorzewska, A., de Lange, T. Senescence induced by altered telomere state, not telomere loss. (2002) Science. 295(5564):2446-9. DOI: 10.1126/science.1069523

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Wolschek, M.F., Narendja, F., Karlseder, J., Kubicek, C.P., Scazzocchio, C., Strauss, J. In situ detection of protein-DNA interactions in filamentous fungi by in vivo footprinting. (1998) Nucleic Acids Res. 26(16):3862-4.

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Sliutz, G., Karlseder, J., Tempfer, C., Orel, L., Holzer, G., Simon, M.M. Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy. (1996) Br. J. Cancer. 74(2):172-7.

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Karlseder, J., Rotheneder, H., Wintersberger, E. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. (1996) Mol. Cell. Biol. 16(4):1659-67.

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Karlseder, J., Wissing, D., Holzer, G., Orel, L., Sliutz, G., Auer, H., Jäättelä, M., Simon, M.M. HSP70 overexpression mediates the escape of a doxorubicin-induced G2 cell cycle arrest. (1996) Biochem. Biophys. Res. Commun. 220(1):153-9. DOI: 10.1006/bbrc.1996.0373

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Karlseder, J., Zeillinger, R., Schneeberger, C., Czerwenka, K., Speiser, P., Kubista, E., Birnbaum, D., Gaudray, P., Theillet, C. Patterns of DNA amplification at band q13 of chromosome 11 in human breast cancer. (1994) Genes Chromosomes Cancer. 9(1):42-8.

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Education

BS, Biology, University of Innsbruck, Austria
PhD, Molecular Biology, University of Vienna


Awards & Honors

  • 2002 The V-Foundation Award for Developing Scientists
  • 1999 Charles H. Revson Fellowship
  • 1997 Human Frontiers Science Program Fellowship
  • 1993 European Molecular Biology Organization Fellowship