Jan Karlseder


Molecular and Cell Biology Laboratory

Donald and Darlene Shiley Chair

Salk Institute for Biological Studies - Publications


M. Hayashi, A.J. Cesare, T. Rivera, J. Karlseder, Cell death in crisis is mediated by mitotic telomere deprotection. Nature 25;522:492-496, 2015.

N. Arnoult, J. Karlseder, ALT telomere borrow from mitosis to get moving, 2014, Cell, 159 (1), 11-12.

J. Karlseder, Modern genome editing meets telomeres: the many functions of TPP1, 2014, Genes Dev., 28 (17), 1857-1858.

O'Sullivan, R.J., Arnoult, N., Lackner, D.H., Oganesian, L., Haggblom, C., Corpet, A., Almounzi, G. and Karlseder, J. (2014) Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. Nat Struct Mol Biol 21:167-174.

Cesare, A.J., Hayashi, M.T., Crabbe, L. and Karlseder, J. (2013) The telomere deprotection response is functionally distinct from the genomic DNA damage response. Mol Cell. 51:141-155.

Hayashi, M.T. and Karlseder, J. (2013) DNA damage associated with mitosis and cytokinesis failure. Oncogene. 32:4593-4601.

Lackner, D.H. and Karlseder, J. (2013) C. elegans survivors without telomerase. Worm 2:e21073.

Oganesian, L. and Karlseder, J (2013) 5' C-rich telomeric overhangs are an outcome of rapid telomere truncation events. DNA Repair. 12:238-245.

Barefield, C. and Karlseder, J. (2012) The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures. Nucleic Acids Res 40:7358-7367.

Cesare, A.J. and Karlseder, J. (2012) A three-state model of telomere control over human proliferative boundaries. Curr Opin Cell Biol. 24:731-738.

Crabbe, L., Cesare, A.J., Kasuboski, J.M., Fitzpatrick, J.A. and Karlseder, J. (2012) Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly. Cell Rep. 2:1521-1529.

O'Sullivan, R. and Karlseder, J. (2012) The great unravelling: chromatin as a modulator of the aging process. Trends Biochem Sci. 37:466-476.

Hayashi, M.T., Cesare, A.J., Fitzpatrick, J.A.J., Lazzerini-Denchi, E. and Karlseder, J. (2012) A Telomere Dependent DNA Damage Checkpoint Induced by Prolonged Mitotic Arrest. Nat Struct Mol Biol 19:387-94.

Lackner, D.H., Raices, M., Maruyama, H., Haggblom, C. and Karlseder, J. (2012) Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans. EMBO J 31:2024-33.

Oganesian, L. and Karlseder, J. (2011) Mammalian 5' C-rich telomeric overhangs are a mark of recombination-dependent telomere maintenance. Mol Cell 42:224-236.

Lackner, D., Durocher, D. and Karlseder, J. (2011) A siRNA-based screen for genes involved in chromosome end protection. PLoSONE 6:e21407.

O'Sullivan, R.J., Kubicek, S., Schreiber, S.L. and Karlseder, J. (2010) Reduced histone biosynthesis and chromatin changes aging arising from a damage signal at telomeres. Nat Struct Mol Biol. 17:1218-1225.

O'Sullivan, R.J. and Karlseder, J. (2010) Telomeres: protecting chromosomes against genome instability. Nat Rev Mol Cell Biol 11:171-181.

Raices, M., Verdun, R., Compton, S., Haggblom, C., Griffith, J., Dillin, A. and Karlseder, J. (2008) C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. Cell 132:745-757.

Verdun, R.E. and Karlseder, J. (2007) Replication and protection of telomeres. Nature 447:924-931.

Crabbe, L., Jauch, A., Naeger, C.M., Holtgreve-Grez, H. and Karlseder, J. (2007) Telomere dysfunction as a cause of genomic instability in Werner syndrome. Proc Natl Acad Sci USA 104:2205-2210.

Verdun, R.E. and Karlseder, J. (2006) The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. Cell 127:709-720.

Karlseder, J. (2006) Telomeric proteins: clearing the way for the replication fork. Nat Struct Mol Biol 13:386-387.

Verdun, R.E., Crabbe, L., Haggblom, C. and Karlseder, J. (2005) Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol Cell 20:551-561.

Raices, M., Maruyama, H., Dillin, A. and Karlseder, J. (2005) Uncoupling of longevity and telomere length in C. elegans. PLoS Genet 1:e30.

Crabbe, L., Verdun, R.E., Haggblom, C.I. and Karlseder, J. (2004) Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science 306:1951-1953.


BS, Biology, University of Innsbruck, Austria
PhD, Molecular Biology, University of Vienna

Awards & Honors

  • 2002 The V-Foundation Award for Developing Scientists
  • 1999 Charles H. Revson Fellowship
  • 1997 Human Frontiers Science Program Fellowship
  • 1993 European Molecular Biology Organization Fellowship