Salk Institute
O'Shea lab
Scientific Core Facilities
Scientific Core Facilities
  • Advanced Biophotonics (BPHO)
    The Waitt Advanced Biophotonics Center Core facility provides technical and logistical access for Salk faculty to advanced fixed and live cell fluorescence imaging and charged particle imaging methods.
  • Behavior Testing Core (BTC)
    The Behavior Testing Core provides a comprehensive resource for behavioral phenotyping and standardized neurobehavioral testing.
  • Flow Cytometry (FCCF)
    The Flow Cytometry Core facility is dedicated to advancing research projects requiring cell sorting and/or analysis of cell populations by flow cytometry.
  • Functional Genomics (FGL)
    The Functional Genomics Core provides gene expression profiling using standard Affymetrix arrays and custom cDNA or oligo arrays. Quantitative PCR using ABI Prism Sequence Detection Systems.
  • Genome Manipulation Core (GMC)
    The Genome Manipulation Core provides services to generate homologous recombination-base gene targeted mouse embryonic stem (mES) cell lines for making genetically altered mouse models.
  • Gene Transfer Targeting and Therapeutics Core (GT3)
    The Gene Transfer, Targeting and Therapeutics Core facility provides design, consultation and production services for retrovirus (MMLV/MSCV), lentivirus (HIV/EIAV), adeno-associated virus (rAAV2 with multiple capsids), adenovirus (Ad5), rabies virus (g-deleted SAD B19) and vesicular stomatitis virus (VSV) -based viral vector systems.
  • Integrative Genomics and Bioinformatics Core (IGC)
    The Razavi Newman Integrative Genomics and Bioinformatics Core facility focuses on the analysis of next-generation sequencing (NGS) and other genomics data as well as develop novel analysis algorithms.
  • Histology and Imaging Core Facility (HIC)
    The Histology and Imaging Core facility provides routine and experimental histological services as well as training and supervision of various equipment and techniques necessary for pathological analysis and characterization of tissues and cells for Salk and SCRM researchers.
  • Mass Spectrometry Core (MASS)
    The Mass Spectrometry Core for Proteomics and Metabolomics offers an array of services from protein identification and proteomic profiling to more complex studies using state of the art instrumentation.
  • Media Preparation Core (MPRP)
    A small media preparation facility provides routine and specialized cell culture media. Orders up to 40 liters may be placed per requisition. All media are checked for sterility before, during, and after preparation to ensure that laboratories receive reliable products. Meeting the individual needs of each user is considered essential.
  • Peptide Synthesis
    Synthesis of inexpensive peptides for Salk scientists: providing unmodified, biotinylated, acetylated, or phosphorylated peptides.
  • Next Generation Sequencing (NGS)
    The H.A. and Mary K. Chapman Charitable Foundations Genomic Sequencing Core provides Salk researchers with access to low-cost, rapid-turnaround high-throughput sequencing services, offers consultation and training in NGS-based methods and assists in NGS method development.
  • Stem Cell Core (STEM)
    Supports the needs of Salk researchers for human ES and reprogrammed iPS cell culture. Offers training and the physical space to carry out experiments using pluripotent cell types.
  • Transgenic Core (TGC)
    The Transgenic Core provides services to create transgenic and knockout mouse models. Core services include DNA and ES cell microinjection, lentiviral injection, in-vitro fertilization (IVF), cryopreservation, rederivation and teratoma formation.

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