Understanding how effector CD8 T cell differentiation is regulated to generate cells of diverse cell fates is important and much progress has been made in identifying several transcriptional factors that regulate effector and memory cell fates, function and phenotypes. In this talk we discuss how memory T cells form during infection and are specialized into distinct subsets that maximize the way in which they provide immunosurveillance throughout the body and long-term protective immunity.
This lecture was part of “Impact of Infectious Disease on Humans & our Origins”, a virtual CARTA* symposium. More information about the symposium here»
As the COVID-19 pandemic illustrates, infectious diseases can have profound influences on their host populations. Human evolution has unquestionably been shaped by past infections. However, humans have also shaped pathogen dynamics and virulence via a multitude of factors. Some ancient human influences range from changes in social organization, group size, and the exploitation of more varied ecosystems. More recently, developments such as settlement, agriculture, technology, rapid long-distance travel, medicine, and global economic integration, continue to shape epidemics and the human host populations. The goal of this public symposium is to explore how infectious agents and humans shape each other’s evolutionary trajectories.
The Center for Academic Research and Training in Anthropogeny* (CARTA) is a virtual organization formed in order to promote transdisciplinary research into human origins, drawing on methods from a number of traditional disciplines spanning the social, biomedical, biological, computational and engineering, physical and chemical sciences, and the humanities. CARTA began as a collaboration between faculty at UC San Diego and at the Salk Institute for Biological Studies, along with interested scientists at other institutions. In January 2008, CARTA became a UC San Diego recognized Organized Research Unit (ORU).