Program
#MechModels2023*Final program/schedule will be announced closer to the event.
Salk Mechanisms and Models of Cancer, Aug 1 – 4, 2023
Co-organizers (Diana Hargreaves, Nik Joshi, Mara Sherman, Reuben Shaw, and Dannielle Engle)
Speakers
Laura Attardi (Stanford)
Adriene Boire (MSKCC)
Hannah Carter (UCSD)
Howard Chang (Stanford)
Heather Christofk (UCLA)
Karen Cichowski (Harvard Med)
Ralph DeBeraradinis (UTSW)
Doug Green (St Jude’s)
Scott Lowe (MSKCC)
Amanda Lund (NYU)
Lydia Lynch (Harvard Med)
Nicola Mason (UPenn)
Martin McMahon (Utah)
Thales Papagiannakopoulos (NYU)
Katie Politi (Yale)
Daniela Quail (McGill)
Sohail Tavazoie (Rockefeller)
Chris Vakoc (CSHL)
Matt Vander Heiden (MIT)
Eileen White (Rutger/NJCC)
Tuesday, August 1
| 12:00 p.m. | Meeting Registration opens |
| 4:00 p.m.-8:20 p.m. | Session 1: Mechanisms |
| 4:00 p.m.-4:30 p.m. | Laura Attardi (Stanford University) p53 Governs an AT1 Differentiation Program During Lung Adenocarcinoma Suppression |
| 4:30 p.m.-4:50 p.m. | Adrian Vega-Perez (Weill Cornell Medicine) Rapid Generation of Precision Preclinical Cancer Models using Regulated In Vivo Base Editing |
| 4:50 p.m.-5:10 p.m. | Katie Grausam (Cedars-Sinai in Los Angeles) A Series of EGFR-mutant Models of Glioblastoma that Recapitulates Patient Tumor Heterogeneity and Response to Treatment |
| 5:10 p.m.-5:40 p.m. | Karen Cichowski (Harvard Medical School) Developing Combinatorial Therapies for KRAS-mutant Cancers |
| 5:40 p.m.-6:00 p.m. | Lillian Eichner (Northwestern University) HDAC3 is Critical in Tumor Development and Therapeutic Resistance in Kras-mutant Non-small Cell Lung Cancer |
| 6:00 p.m.-7:00 p.m. | Dinner |
| 7:00 p.m.-7:30 p.m. | Nicola Mason (University of Pennsylvania) Integrating Canine Cancer Patients into the Development of Next Generation Cellular Therapies for Human Translation |
| 7:30 p.m.-7:50 p.m. | Alissandra Hillis (Harvard Medical School) AKT Inhibition Synergizes with Mevalonate Pathway Disruption in TNBC |
| 7:50 p.m.-8:20 p.m. | Martin McMahon (University of Utah) Direct Pharmacological Targeting of NRAS Oncoproteins for Future Therapy of NRAS-driven Melanoma |
| 8:20 p.m.-10:00 p.m. | Welcome Party in downstairs foyer at Salk Institute |
Wednesday, August 2
| 8:00 a.m.-9:00 a.m. | Breakfast |
| 9:00 a.m.-12:15 p.m. | Session 2: Genetics and Epigenetics |
| 9:00 a.m.-9:30 a.m. | Howard Chang (Stanford University) Cancer Genes Beyond Chromosomes |
| 9:30 a.m.-9:50 a.m. | Zhichao Xu (Salk Institute) Recurrent 3D Genome Structural Alterations Facilitate Activity Dependent Oncogene Expression |
| 9:50 a.m.-10:10 a.m. | Corina Antal (Salk Institute) A Super-enhancer Regulated RNA-binding Protein Cascade Drives Pancreatic Cancer |
| 10:10 a.m.-10:30 a.m. | Yuning Jackie Tang (Stanford University) Massively Parallel Mapping of Epigenetic Regulators Identify Critical Regulatory Circuits of Lung Cancer |
| 10:30 a.m.-10:45 a.m. | Coffee Break |
| 10:45 a.m.-11:15 a.m. | Chris Vakoc (Cold Spring Harbor Laboratory) Tumor Lineage Plasticity Mechanisms Revealed by Genetic Screens |
| 11:15 a.m.-11:35 a.m. | Carman Li (Harvard Medical School) Epigenetic Changes Associated with Germline BRCA1 Heterozygosity and Accelerated Tumorigenesis Revealed by a Genetically Engineered Mouse Model for BRCA1 Hereditary Breast Cancer |
| 11:35 a.m.-11:55 a.m. | Matthew Maxwell (Salk Institute) Loss of the ARID1A Tumor Suppressor Activates an R-loop Driven STING-Type I Interferon Signaling Axis that Promotes Anti-Tumor Immunity |
| 11:55 a.m.-12:15 p.m. | Xueqian Zhuang (MSKCC) Aging-induced Epigenetic Reprogramming of the Cell of Origin Defines Lung Cancer Evolution |
| 12:15 p.m.-1:30 p.m. | Lunch & Poster Session 1 |
| 1:30 p.m.-5:40 p.m. | Session 3: Tumor Microenvironment / Immunology |
| 1:30 p.m.-2:00 p.m. | Amanda Lund (New York University) Lymphatic Transport and the Intratumoral T Cell Repertoire |
| 2:20 p.m.-2:40 p.m. | Melissa Reeves (University of Utah) Spatial Heterogeneity of Tumor Cells Drives Intratumoral Organization of Immune Cells and Impedes Immunotherapy |
| 2:40 p.m.-3:00 p.m. | Goran Micevic (Yale School of Medicine) Epigenetically Poised CD8+ T cells Marked by IL-7R are Critical for Antitumor Memory |
| 3:00 p.m.-3:30 p.m. | Lydia Lynch (Harvard University) To Be Announced |
| 3:30 p.m.-3:50 p.m. | Coffee Break |
| 3:50 p.m.- 4:20 p.m. | Doug Green (St. Jude Children’s Research Hospital) Flatliners: Near Death Experiences in Cancer Cells |
| 4:20 p.m.-4:40 p.m. | Anna-Maria Globig (Salk Institute) Adrenergic Receptors Regulate T Cell Differentiation in Viral Infection and Cancer |
| 4:40 p.m.-5:00 p.m. | Melissa Johnson (Salk Institute) Interferon-induced Metabolic Rewiring Promotes the Survival and Immunoevasive Properties of Melanoma Cells |
| 5:00 p.m.-5:20 p.m. | Martina Damo (Yale School of Medicine) PD-1 Safeguards Against Cutaneous Immunopathology by Local Neoantigen-specific CD8 T cells |
| 5:20 p.m.-5:40 p.m. | Melissa Meyer (Immunology Center of Georgia) LIGHT Loss Enhances Response to Immunotherapy in Solid Tumors |
| 6:30 p.m.-9:00 p.m. | Reception/Dinner at Gravity Heights (RSVP required; shuttle busses available at 6:00 p.m.) |
Thursday, August 3
| 8:00 a.m.-9:00 a.m. | Breakfast |
| 9:00 a.m.-12:30 p.m. | Session 4: Cancer Metabolism |
| 9:00 a.m.-9:30 a.m. | Heather Christofk (University of California, Los Angeles) Tumor Suppressor-Driven Metabolic Dependencies |
| 9:30 a.m.-9:50 a.m. | Sam Kerk (University of Michigan) Metabolic Reprogramming of Myeloid Cells in Pancreatic Cancer |
| 9:50 a.m.-10:10 a.m. | Karl Wessendorf-Rodriguez (Salk Institute) Modeling Sphingolipid Metabolism Using Stable Isotope Tracing |
| 10:10 a.m.-10:40 a.m. | Ralph DeBerardinis (University of Texas Southwestern) Metabolic Reprogramming and Cancer Progression in Patients |
| 10:40 a.m.-11:00 a.m. | Coffee Break |
| 11:00 a.m.-11:30 a.m. | Matthew VanderHeiden (Massachusetts Institute of Technology) Influence of Metabolism on Cancer Progression |
| 11:30 a.m.-11:50 a.m. | Mingqi Han (University of California, Los Angeles) LKB1 Regulates Mitochondrial Networks and Bioenergetics Spatially and Temporally in Lung Cancer |
| 11:50 a.m.-12:10 p.m. | Benjamin Stein (Weill Cornell Medicine) LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma |
| 12:10 p.m.-12:30 p.m. | Cristina Andreani (University of Cincinnati) Resistance to FASN Inhibition and Ferroptosis in Mutant KRAS Lung Cancer |
| 12:30 p.m.-2:00 p.m. | Lunch & Poster Session 2 |
| 2:00 p.m.-4:10 p.m. | Session 5: Models & More |
| 2:00 p.m.-2:30 p.m. | Eileen White (Rutgers University Cancer Institute of NJ (CINJ)) Metabolic Alterations in Tumor and Host in Cancer |
| 2:30 p.m.-2:50 p.m. | Christina Towers (Salk Institute) Optogenetic Regulation of Autophagy Allows for Rapid and Reversible Manipulation |
| 3:10 p.m.-3:40 p.m. | Sohail Tavazoie (The Rockefeller University) Biology, Genetics and Experimental Therapy of Metastatic Disease |
| 3:40 p.m.-4:10 p.m. | Scott Lowe (MSKCC) Understanding and Exploiting Natural Barriers to Pancreatic Tumorigenesis |
| 4:10 p.m.-5:00 p.m. | Free time |
| 5:00 p.m.-9:00 p.m. | Reception/Dinner at Il Fornaio (RSVP required; shuttle busses available at 4:30 p.m.) |
Friday, August 4
| 8:00 a.m.-9:00 a.m. | Breakfast |
| 9:00 a.m.-3:30 p.m. | Session 6 Metastasis and more |
| 9:00 a.m.-9:30 a.m. | Thales Papagiannakopoulos (New York University) Uncovering the Mechanisms of Disease Progression in Genetic Subsets of KRAS Mutant Lung Cancer |
| 9:30 a.m.-10:00 a.m. | Jan Remsik for Adrienne Biore (MSKCC) Interferon-γ Mediates Reprogramming of Innate Anti-tumor Immunity in the Leptomeninges |
| 10:00 a.m.-10:20 a.m. | Ruth Palmer (University of Gothenburg) ALK Signaling Primes the DNA Damage Response Allowing Exploitation of ATR Inhibition in ALK-driven Neuroblastoma |
| 10:20 a.m.-10:40 a.m. | Florian Karreth (Moffitt Cancer Center) Control of PHGDH Expression by a MAPK/ATF4 Axis Establishes a Metabolic Vulnerability in Melanoma |
| 10:40 a.m.-11:00 a.m. | Coffee Break |
| 11:00 a.m.-11:30 a.m. | Katerina Politi (Yale School of Medicine) Mechanisms of Drug Resistance in Lung Cancer |
| 11:30 a.m.-11:50 a.m. | Jonathan Weitz (University of California, San Diego) Pancreatic Ductal Adenocarcinoma Induces Neural Injury that Promotes a Transcriptomic and Functional Repair Signature by Peripheral Neuroglia |
| 12:00 p.m.-1:00 p.m. | Lunch | 1:00 p.m.-1:30 p.m. | Hannah Carter (University of California, San Diego) Common Germline Variation Modulates Anti-tumor Immunity |
| 1:30 p.m.-1:50 p.m. | Erik Bergstrom (University of California, San Diego) Mapping Clustered Mutations in Cancer Reveals APOBEC3 Mutagenesis of ecDNA |
| 1:50 p.m.-2:10 p.m. | Benjamin Spike (University of Utah Huntsman CC) Cellular Crosstalk and Stress-Adaptive Plasticity: Deciphering CRIPTO’s Role in Triple Negative Breast Cancer |
| 2:10 p.m.-2:40 p.m. | Kota Kaneko (University of California, San Diego) CD133+ Intercellsome Mediates Direct Cell-cell Communication to Offset Intracellular Signal Deficit |
| 2:40 p.m.-3:00 p.m. | Mengzhou (Clara) Hu (University of California, San Diego) A Comprehensive Map of Osteosarcoma Cell Architecture Reveals Mechanistic Interpretations of Pediatric Cancer Genomes |
| 3:00 p.m.-3:30 p.m. | Daniela Quail (McGill University) Leveraging Myeloid Functional States to Combat Cancer |
| 3:30 p.m.-5:00 p.m. | Wine & Cheese Reception on Red Brick Courtyard; meeting adjourns |
