Salk Institute

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Tuesday, September 22, 2015

3:00 p.m. - 5:00 p.m.

Jun Wu
Jun Wu, Ph.D.
Jun Wu, Ph.D. - Harnessing pluripotent stem cells for generating functional human organs
As a mammalian species humans have largely lost their regeneration capacity to repair tissue damages acquired through aging, injury and diseases. Organ donation remains the only viable option for restoring tissue integrity and saving human lives. The demand for organ transplantation has rapidly increased worldwide which has subsequently created a severe shortage of organ donors. Human pluripotent stem cells (hPSCs) offer the hope to eradicate donor organ shortages owing to their unlimited proliferation and ability to generate any tissues in the body, however, have yet to be harnessed to attain this goal. We propose to generate functional human organs and tissues in vivo in a large animal host, the pig, using a novel interspecific chimeric complementation system.

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