Xin Jin

Associate Professor

Molecular Neurobiology Laboratory

Salk Institute for Biological Studies - Publications

all Publications


Aoki, S., Smith, J.B., Li, H., Yan, X., Igarashi, M., Coulon, P., Wickens, J.R., Ruigrok, T.J., Jin, X. An open cortico-basal ganglia loop allows limbic control over motor output via the nigrothalamic pathway. (2019) Elife. 8. DOI: 10.7554/eLife.49995

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Geddes, C.E., Li, H., Jin, X. Optogenetic Editing Reveals the Hierarchical Organization of Learned Action Sequences. (2018) Cell. 174(1):32-43.e15. DOI: 10.1016/j.cell.2018.06.012

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Klug, J.R., Engelhardt, M.D., Cadman, C.N., Li, H., Smith, J.B., Ayala, S., Williams, E.W., Hoffman, H., Jin, X. Differential inputs to striatal cholinergic and parvalbumin interneurons imply functional distinctions. (2018) Elife. 7. DOI: 10.7554/eLife.35657

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Sarkar, A., Mei, A., Paquola, A.C.M., Stern, S., Bardy, C., Klug, J.R., Kim, S., Neshat, N., Kim, H.J., Ku, M., Shokhirev, M.N., Adamowicz, D.H., Marchetto, M.C., Jappelli, R., Erwin, J.A., Padmanabhan, K., Shtrahman, M., Jin, X., Gage, F.H. Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro. (2018) Cell Stem Cell. 22(5):684-697.e9. DOI: 10.1016/j.stem.2018.04.009

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Mansour, A.A., Gonçalves, J.T., Bloyd, C.W., Li, H., Fernandes, S., Quang, D., Johnston, S., Parylak, S.L., Jin, X., Gage, F.H. An in vivo model of functional and vascularized human brain organoids. (2018) Nature Biotechnology. DOI: 10.1038/nbt.4127

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Howard, C.D., Li, H., Geddes, C.E., Jin, X. Dynamic Nigrostriatal Dopamine Biases Action Selection. (2017) Neuron. 93(6):1436-1450.e8. DOI: 10.1016/j.neuron.2017.02.029

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Smith, J.B., Klug, J.R., Ross, D.L., Howard, C.D., Hollon, N.G., Ko, V.I., Hoffman, H., Callaway, E.M., Gerfen, C.R., Jin, X. Genetic-Based Dissection Unveils the Inputs and Outputs of Striatal Patch and Matrix Compartments. (2016) Neuron. 91(5):1069-1084. DOI: 10.1016/j.neuron.2016.07.046

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Tecuapetla, F., Jin, X., Lima, S.Q., Costa, R.M. Complementary Contributions of Striatal Projection Pathways to Action Initiation and Execution. (2016) Cell. 166(3):703-15. DOI: 10.1016/j.cell.2016.06.032

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Amin, N.D., Bai, G., Klug, J.R., Bonanomi, D., Pankratz, M.T., Gifford, W.D., Hinckley, C.A., Sternfeld, M.J., Driscoll, S.P., Dominguez, B., Lee, K.F., Jin, X., Pfaff, S.L. Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure. (2015) Science. 350(6267):1525-9. DOI: 10.1126/science.aad2509

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Santos, F.J., Oliveira, R.F., Jin, X., Costa, R.M. Corticostriatal dynamics encode the refinement of specific behavioral variability during skill learning. (2015) Elife. 4:e09423. DOI: 10.7554/eLife.09423

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Jin, X., Costa, R.M. Shaping action sequences in basal ganglia circuits. (2015) Current Opinion in Neurobiology. 33:188-96. DOI: 10.1016/j.conb.2015.06.011

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Jin, X., Tecuapetla, F., Costa, R.M. Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences. (2014) Nature Neuroscience. 17(3):423-30. DOI: 10.1038/nn.3632

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Cui, G., Jun, S.B., Jin, X., Pham, M.D., Vogel, S.S., Lovinger, D.M., Costa, R.M. Concurrent activation of striatal direct and indirect pathways during action initiation. (2013) Nature. 494(7436):238-42. DOI: 10.1038/nature11846

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French, C.A., Jin, X., Campbell, T.G., Gerfen, Groszer, M., Fisher, S.E., Costa, R.M. An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning. (2012) Molecular Psychiatry. 17(11):1770-1085. DOI: 10.1038/mp.2011.105

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Koralek, A.C.*, Jin, X.*, Long, J.D., Costa, R.M., Carmena, J.M. Corticostriatal plasticity is necessary for learning intentional neuroprosthetic skills. (2012) Nature. 483(7389):331-5. DOI: 10.1038/nature10845

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Jin, X., Costa, R.M. Start/stop signals emerge in nigrostriatal circuits during sequence learning. (2010) Nature. 466(7305):457-62. DOI: 10.1038/nature09263

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Education

BS, China Agricultural University, China
PhD, Shanghai Jiao Tong University, China
Postdoctoral Fellow, National Institutes of Health


Affiliations


Awards & Honors

  • 2018 McKnight Memory and Cognitive Disorders Award
  • 2013-2016 Whitehall Foundation Award
  • 2012-2016 Ellison Medical Foundation New Scholar in Aging Award
  • 2011 Society for Neuroscience Gruber International Research Award
  • 2011 NIAAA/NIH Benedict J. Latteri Award
  • 2011 Portuguese Society for Neuroscience Featured Article Award

Profile