Xin Jin

Associate Professor

Molecular Neurobiology Laboratory

Salk Institute for Biological Studies - Publications


Geddes C.E., Li H. and Jin X. (2018) Optogenetic editing reveals the hierarchical organization of learned action sequences. Cell 174: 32-43.

Klug J.R., Engelhardt M.D., Cadman C.N., Li H., Smith J.B., Ayala S., Williams E.W., Hoffman H. and Jin X. (2018) Differential inputs to striatal cholinergic and parvalbumin interneurons imply functional distinctions. eLife 7: e35657.

Mansour A.A., Gonçalves J.T., Bloyd C.W., Li H., Fernandes S., Quang D., Johnston S., Parylak S.L., Jin X. and Gage F.H. (2018) An in vivo model of functional and vascularized human brain organoids. Nature Biotechnology doi:10.1038/nbt.4127

Sarkar A., Mei A., Paquola A.C.M., Stern S., Bardy C., Klug J.R., Kim S., Neshat N., Kim H.J., Ku M., Shokhirev M.N., Adamowicz D.H., Marchetto M.C., Jappelli R., Erwin J.A., Padmanabhan K., Shtrahman M., Jin X. and Gage F.H. (2018) Efficient generation of CA3 neurons from human pluripotent stem cells enables modeling of hippocampal connectivity in vitro. Cell Stem Cell 22: 684-697.

Howard C.D., Li H., Geddes C.E. and Jin X. (2017) Dynamic nigrostriatal dopamine biases action selection. Neuron 93: 1436-1450.

Smith J.B., Klug J.R., Ross D.L., Howard C.D., Hollon N.G., Ko, V.I., Hoffman H., Callaway E.M., Gerfen C.R. and Jin X. (2016) Genetic-based dissection unveils the inputs and outputs of striatal patch and matrix compartments. Neuron 91: 1069-1084.

Tecuapetla F., Jin X., Lima S.Q. and Costa R.M. (2016) Complementary contributions of striatal projection pathways to action initiation and execution. Cell 166: 703-715.

Amin N.D., Bai G., Klug J.R., Bonanomi D., Pankratz M.T., Gifford W.D., Hinckley C.A., Sternfeld M.J., Driscoll S.P., Dominguez B., Lee K.F., Jin X. and Pfaff S.L. (2015) Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure. Science 350: 1525-1529.

Jin X. and Costa R.M. (2015) Shaping action sequences in basal ganglia circuits. Current Opinion in Neurobiology 33: 188-196.

Santos F.J., Oliveira R.F., Jin X. and Costa R.M. (2015) Corticostriatal dynamics encode the refinement of specific behavioral variability during skill learning. eLife 4: e09423.

Jin X., Tecuapetla F. and Costa R.M. (2014) Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences. Nature Neuroscience 17: 423-430.

Cui G., Jun S.B., Jin X., Pham M.D., Vogel S.S., Lovinger D.M. and Costa R.M. (2013) Concurrent activation of striatal direct and indirect pathways during action initiation. Nature 494: 238-242.

French C.A., Jin X., Campbell T.G., Gerfen E., Groszer M., Fisher S.E. and Costa R.M. (2012) An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning. Molecular Psychiatry 17: 1077-1085.

Koralek A.C.*, Jin X.*, Long II J.D., Costa R.M. and Carmena J.M. (2012) Corticostriatal plasticity is necessary for learning intentional neuroprosthetic skills. Nature 483: 331-335. (* equal contribution)

Jin X. and Costa R.M. (2010) Start/stop signals emerge in nigrostriatal circuits during sequence learning. Nature 466: 457-462.


BS, China Agricultural University, China
PhD, Shanghai Jiao Tong University, China
Postdoctoral Fellow, National Institutes of Health

Awards & Honors

  • 2018 McKnight Memory and Cognitive Disorders Award
  • 2013-2016 Whitehall Foundation Award
  • 2012-2016 Ellison Medical Foundation New Scholar in Aging Award
  • 2011 Society for Neuroscience Gruber International Research Award
  • 2011 NIAAA/NIH Benedict J. Latteri Award
  • 2011 Portuguese Society for Neuroscience Featured Article Award