Wolfgang Busch

Associate Professor
Plant Molecular and Cellular Biology Laboratory
Integrative Biology Laboratory

Salk Institute for Biological Studies - Publications

all Publications


Smakowska-Luzan, E., Mott, G.A., Parys, K., Stegmann, M., Howton, T.C., Layeghifard, M., Neuhold, J., Lehner, A., Kong, J., Grünwald, K., Weinberger, N., Satbhai, S.B., Mayer, D., Busch, W., Madalinski, M., Stolt-Bergner, P., Provart, N.J., Mukhtar, M.S., Zipfel, C., Desveaux, D., Guttman, D.S., Belkhadir, Y. Publisher Correction: An extracellular network of Arabidopsis leucine-rich repeat receptor kinases. (2018) Nature. DOI: 10.1038/s41586-018-0268-y

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Ristova, D., Giovannetti, M., Metesch, K., Busch, W. Natural Genetic Variation Shapes Root System Responses to Phytohormones in Arabidopsis. (2018) Plant J. DOI: 10.1111/tpj.14034

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Bouain, N., Satbhai, S.B., Korte, A., Saenchai, C., Desbrosses, G., Berthomieu, P., Busch, W., Rouached, H. Natural allelic variation of the AZI1 gene controls root growth under zinc-limiting condition. (2018) PLoS Genet. 14(4):e1007304. DOI: 10.1371/journal.pgen.1007304

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Mabuchi, K., Maki, H., Itaya, T., Suzuki, T., Nomoto, M., Sakaoka, S., Morikami, A., Higashiyama, T., Tada, Y., Busch, W., Tsukagoshi, H. MYB30 links ROS signaling, root cell elongation, and plant immune responses. (2018) Proc. Natl. Acad. Sci. U.S.A. DOI: 10.1073/pnas.1804233115

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Exposito-Alonso, M., Becker, C., Schuenemann, V.J., Reiter, E., Setzer, C., Slovak, R., Brachi, B., Hagmann, J., Grimm, D.G., Chen, J., Busch, W., Bergelson, J., Ness, R.W., Krause, J., Burbano, H.A., Weigel, D. The rate and potential relevance of new mutations in a colonizing plant lineage. (2018) PLoS Genet. 14(2):e1007155. DOI: 10.1371/journal.pgen.1007155

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Shibata, M., Breuer, C., Kawamura, A., Clark, N.M., Rymen, B., Braidwood, L., Morohashi, K., Busch, W., Benfey, P.N., Sozzani, R., Sugimoto, K. GTL1 and DF1 regulate root hair growth through transcriptional repression ofin. (2018) Development. 145(3). DOI: 10.1242/dev.159707

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Kisko, M., Bouain, N., Safi, A., Medici, A., Akkers, R.C., Secco, D., Fouret, G., Krouk, G., Aarts, M.G., Busch, W., Rouached, H. LPCAT1 controls phosphate homeostasis in a zinc-dependent manner. (2018) Elife. 7. DOI: 10.7554/eLife.32077

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Smakowska-Luzan, E., Mott, G.A., Parys, K., Stegmann, M., Howton, T.C., Layeghifard, M., Neuhold, J., Lehner, A., Kong, J., Grünwald, K., Weinberger, N., Satbhai, S.B., Mayer, D., Busch, W., Madalinski, M., Stolt-Bergner, P., Provart, N.J., Mukhtar, M.S., Zipfel, C., Desveaux, D., Guttman, D.S., Belkhadir, Y. An extracellular network of Arabidopsis leucine-rich repeat receptor kinases. (2018) Nature. DOI: 10.1038/nature25184

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Friesner, J., Assmann, S.M., Bastow, R., Bailey-Serres, J., Beynon, J., Brendel, V., Buell, C.R., Bucksch, A., Busch, W., Demura, T., Dinneny, J.R., Doherty, C.J., Eveland, A.L., Falter-Braun, P., Gehan, M.A., Gonzales, M., Grotewold, E., Gutierrez, R., Kramer, U., Krouk, G., Ma, S., Markelz, R.J.C., Megraw, M., Meyers, B.C., Murray, J.A.H., Provart, N.J., Rhee, S., Smith, R., Spalding, E.P., Taylor, C., Teal, T.K., Torii, K.U., Town, C., Vaughn, M., Vierstra, R., Ware, D., Wilkins, O., Williams, C., Brady, S.M. The Next Generation of Training for Arabidopsis Researchers: Bioinformatics and Quantitative Biology. (2017) Plant Physiol. 175(4):1499-1509. DOI: 10.1104/pp.17.01490


Munch, D., Gupta, V., Mun, T., Bachmann, A., Busch, W., Kelly, S., Andersen, S.U. The Brassicaceae family displays divergent, shoot-skewed NLR resistance gene expression. (2017) Plant Physiol. DOI: 10.1104/pp.17.01606

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Di Mambro, R., De Ruvo, M., Pacifici, E., Salvi, E., Sozzani, R., Benfey, P.N., Busch, W., Novak, O., Ljung, K., Di Paola, L., Marée, A.F.M., Costantino, P., Grieneisen, V.A., Sabatini, S. Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root. (2017) Proc. Natl. Acad. Sci. U.S.A. 114(36):E7641-E7649. DOI: 10.1073/pnas.1705833114

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Bouain, N., Satbhai, S.B., Saenchai, C., Desbrosses, G., Berthomieu, P., Busch, W., Rouached, H. Zinc availability modulates plant growth and immune responses via AZI1 (2017) bioRxiv. DOI: https://doi.org/10.1101/166645

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Barbez, E., Dünser, K., Gaidora, A., Lendl, T., Busch, W. Auxin steers root cell expansion via apoplastic pH regulation in Arabidopsis thaliana. (2017) Proc. Natl. Acad. Sci. U.S.A. 114(24):E4884-E4893. DOI: 10.1073/pnas.1613499114

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Satbhai, S.B., Setzer, C., Freynschlag, F., Slovak, R., Kerdaffrec, E., Busch, W. Natural allelic variation of FRO2 modulates Arabidopsis root growth under iron deficiency. (2017) Nat Commun. 8:15603. DOI: 10.1038/ncomms15603

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Vad, V., Cedrim, D., Busch, W., Filzmoser, P., Viola, I. Generalized box-plot for root growth ensembles. (2017) BMC Bioinformatics. 18(Suppl 2):65. DOI: 10.1186/s12859-016-1445-3

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Stoeva, D., Göschl, C., Corliss, B., Busch, W. Long-Term Confocal Imaging of Arabidopsis thaliana Roots for Simultaneous Quantification of Root Growth and Fluorescent Signals. (2017) Methods Mol. Biol. 1610:169-183. DOI: 10.1007/978-1-4939-7003-2_12

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Giovannetti, M., Małolepszy, A., Göschl, C., Busch, W. Large-Scale Phenotyping of Root Traits in the Model Legume Lotus japonicus. (2017) Methods Mol. Biol. 1610:155-167. DOI: 10.1007/978-1-4939-7003-2_11

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Satbhai, S.B., Göschl, C., Busch, W. Automated High-Throughput Root Phenotyping of Arabidopsis thaliana Under Nutrient Deficiency Conditions. (2017) Methods Mol. Biol. 1610:135-153. DOI: 10.1007/978-1-4939-7003-2_10

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Ristova, D., Busch, W. Genome-Wide Association Mapping of Root Traits in the Context of Plant Hormone Research. (2017) Methods Mol. Biol. 1497:47-55. DOI: 10.1007/978-1-4939-6469-7_6

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Klasen, J.R., Barbez, E., Meier, L., Meinshausen, N., Bühlmann, P., Koornneef, M., Busch, W., Schneeberger, K. A multi-marker association method for genome-wide association studies without the need for population structure correction. (2016) Nat Commun. 7:13299. DOI: 10.1038/ncomms13299

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Ristova, D., Carré, C., Pervent, M., Medici, A., Kim, G.J., Scalia, D., Ruffel, S., Birnbaum, K.D., Lacombe, B., Busch, W., Coruzzi, G.M., Krouk, G. Combinatorial interaction network of transcriptomic and phenotypic responses to nitrogen and hormones in the Arabidopsis thaliana root. (2016) Sci Signal. 9(451):rs13. DOI: 10.1126/scisignal.aaf2768

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Ogura, T., Busch, W. Genotypes, Networks, Phenotypes: Moving Toward Plant Systems Genetics. (2016) Annu. Rev. Cell Dev. Biol. 32:103-126. DOI: 10.1146/annurev-cellbio-111315-124922

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Smakowska, E., Kong, J., Busch, W., Belkhadir, Y. Organ-specific regulation of growth-defense tradeoffs by plants. (2016) Curr. Opin. Plant Biol. 29:129-37. DOI: 10.1016/j.pbi.2015.12.005

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Slovak, R., Ogura, T., Satbhai, S.B., Ristova, D., Busch, W. Genetic control of root growth: from genes to networks. (2016) Ann. Bot. 117(1):9-24. DOI: 10.1093/aob/mcv160

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Busch, W., Augustin, M., Haxhimusa, Y., Kropatsch, W. A framework for the extraction of quantitative traits from 2D images of mature Arabidopsis thaliana (2016) Machine Vision and Applications. 5(27).

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Brady, S.M., Burow, M., Busch, W., Carlborg, .., Denby, K.J., Glazebrook, J., Hamilton, E.S., Harmer, S.L., Haswell, E.S., Maloof, J.N., Springer, N.M., Kliebenstein, D.J. Reassess the t Test: Interact with All Your Data via ANOVA. (2015) Plant Cell. 27(8):2088-94. DOI: 10.1105/tpc.15.00238

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Augustin, M., Haxhimusa, Y., Busch, W., Kropatsch, W. Image-Based Phenotyping of the Mature Arabidopsis Shoot System (2015) European Conference on Computer Vision. DOI: https://doi.org/10.1007/978-3-319-16220-1_17


Janusch, I., Kropatsch, W.G., Busch, W., Ristova, D. Representing Roots on the Basis of Reeb Graphs in Plant Phenotyping (2015) Computer Vision - ECCV 2014 Workshops. ECCV 2014. Lecture Notes in Computer Science, vol 8928. DOI: https://doi.org/10.1007/978-3-319-16220-1_6


Satbhai, S.B., Ristova, D., Busch, W. Underground tuning: quantitative regulation of root growth. (2015) J. Exp. Bot. 66(4):1099-112. DOI: 10.1093/jxb/eru529

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Ogura, T., Busch, W. From phenotypes to causal sequences: using genome wide association studies to dissect the sequence basis for variation of plant development. (2015) Curr. Opin. Plant Biol. 23:98-108. DOI: 10.1016/j.pbi.2014.11.008

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Slovak, R., Göschl, C., Seren, .., Busch, W. Genome-wide association mapping in plants exemplified for root growth in Arabidopsis thaliana. (2015) Methods Mol. Biol. 1284:343-57. DOI: 10.1007/978-1-4939-2444-8_17

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Ristova, D., Busch, W. Natural variation of root traits: from development to nutrient uptake. (2014) Plant Physiol. 166(2):518-27. DOI: 10.1104/pp.114.244749

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Janusch, I., Kropatsch, W., Busch, W. Topological Image Analysis and (Normalised) Representations for Plant Phenotyping (2014) 16th International Symposium on Symbolic and Numeric Algorithms for Scientific Computing. DOI: 10.1109/SYNASC.2014.83

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Slovak, R., Göschl, C., Su, X., Shimotani, K., Shiina, T., Busch, W. A Scalable Open-Source Pipeline for Large-Scale Root Phenotyping of Arabidopsis. (2014) Plant Cell. 26(6):2390-2403. DOI: 10.1105/tpc.114.124032

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Sozzani, R., Busch, W., Spalding, E.P., Benfey, P.N. Advanced imaging techniques for the study of plant growth and development. (2014) Trends Plant Sci. 19(5):304-10. DOI: 10.1016/j.tplants.2013.12.003

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Schuster, C., Gaillochet, C., Medzihradszky, A., Busch, W., Daum, G., Krebs, M., Kehle, A., Lohmann, J.U. A regulatory framework for shoot stem cell control integrating metabolic, transcriptional, and phytohormone signals. (2014) Dev. Cell. 28(4):438-49. DOI: 10.1016/j.devcel.2014.01.013

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Meijón, M., Satbhai, S.B., Tsuchimatsu, T., Busch, W. Genome-wide association study using cellular traits identifies a new regulator of root development in Arabidopsis. (2014) Nat. Genet. 46(1):77-81. DOI: 10.1038/ng.2824

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Ischebeck, T., Werner, S., Krishnamoorthy, P., Lerche, J., Meijón, M., Stenzel, I., Löfke, C., Wiessner, T., Im, Y.J., Perera, I.Y., Iven, T., Feussner, I., Busch, W., Boss, W.F., Teichmann, T., Hause, B., Persson, S., Heilmann, I. Phosphatidylinositol 4,5-bisphosphate influences PIN polarization by controlling clathrin-mediated membrane trafficking in Arabidopsis. (2013) Plant Cell. 25(12):4894-911. DOI: 10.1105/tpc.113.116582

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Kaufmann, K., Busch, W. Plant genomics: from weed to wheat. (2013) Genome Biol. 14(6):308. DOI: 10.1186/gb-2013-14-6-308

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Busch, W., Moore, B.T., Martsberger, B., Mace, D.L., Twigg, R.W., Jung, J., Pruteanu-Malinici, I., Kennedy, S.J., Fricke, G.K., Clark, R.L., Ohler, U., Benfey, P.N. A microfluidic device and computational platform for high-throughput live imaging of gene expression. (2012) Nat. Methods. 9(11):1101-6. DOI: 10.1038/nmeth.2185

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Iyer-Pascuzzi, A.S., Jackson, T., Cui, H., Petricka, J.J., Busch, W., Tsukagoshi, H., Benfey, P.N. Cell identity regulators link development and stress responses in the Arabidopsis root. (2011) Dev. Cell. 21(4):770-82. DOI: 10.1016/j.devcel.2011.09.009

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Tsukagoshi, H., Busch, W., Benfey, P.N. Transcriptional regulation of ROS controls transition from proliferation to differentiation in the root. (2010) Cell. 143(4):606-16. DOI: 10.1016/j.cell.2010.10.020

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Long, T.A., Tsukagoshi, H., Busch, W., Lahner, B., Salt, D.E., Benfey, P.N. The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots. (2010) Plant Cell. 22(7):2219-36. DOI: 10.1105/tpc.110.074096

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Sozzani, R., Cui, H., Moreno-Risueno, M.A., Busch, W., Van Norman, J.M., Vernoux, T., Brady, S.M., Dewitte, W., Murray, J.A., Benfey, P.N. Spatiotemporal regulation of cell-cycle genes by SHORTROOT links patterning and growth. (2010) Nature. 466(7302):128-32. DOI: 10.1038/nature09143

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Busch, W., Miotk, A., Ariel, F.D., Zhao, Z., Forner, J., Daum, G., Suzaki, T., Schuster, C., Schultheiss, S.J., Leibfried, A., Haubeiss, S., Ha, N., Chan, R.L., Lohmann, J.U. Transcriptional control of a plant stem cell niche. (2010) Dev. Cell. 18(5):849-61. DOI: 10.1016/j.devcel.2010.03.012

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Busch, W., Benfey, P.N. Information processing without brains--the power of intercellular regulators in plants. (2010) Development. 137(8):1215-26. DOI: 10.1242/dev.034868

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Moreno-Risueno, M.A., Busch, W., Benfey, P.N. Omics meet networks - using systems approaches to infer regulatory networks in plants. (2010) Curr. Opin. Plant Biol. 13(2):126-31. DOI: 10.1016/j.pbi.2009.11.005

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Schultheiss, S.J., Busch, W., Lohmann, J.U., Kohlbacher, O., Rätsch, G. KIRMES: kernel-based identification of regulatory modules in euchromatic sequences. (2009) Bioinformatics. 25(16):2126-33. DOI: 10.1093/bioinformatics/btp278

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Kumar, M., Busch, W., Birke, H., Kemmerling, B., Nürnberger, T., Schöffl, F. Heat shock factors HsfB1 and HsfB2b are involved in the regulation of Pdf1.2 expression and pathogen resistance in Arabidopsis. (2009) Mol Plant. 2(1):152-65. DOI: 10.1093/mp/ssn095

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Fulton, L., Batoux, M., Vaddepalli, P., Yadav, R.K., Busch, W., Andersen, S.U., Jeong, S., Lohmann, J.U., Schneitz, K. DETORQUEO, QUIRKY, and ZERZAUST represent novel components involved in organ development mediated by the receptor-like kinase STRUBBELIG in Arabidopsis thaliana. (2009) PLoS Genet. 5(1):e1000355. DOI: 10.1371/journal.pgen.1000355

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Skirycz, A., Radziejwoski, A., Busch, W., Hannah, M.A., Czeszejko, J., Kwaśniewski, M., Zanor, M.I., Lohmann, J.U., De Veylder, L., Witt, I., Mueller-Roeber, B. The DOF transcription factor OBP1 is involved in cell cycle regulation in Arabidopsis thaliana. (2008) Plant J. 56(5):779-92. DOI: 10.1111/j.1365-313X.2008.03641.x

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Laubinger, S., Sachsenberg, T., Zeller, G., Busch, W., Lohmann, J.U., Rätsch, G., Weigel, D. Dual roles of the nuclear cap-binding complex and SERRATE in pre-mRNA splicing and microRNA processing in Arabidopsis thaliana. (2008) Proc. Natl. Acad. Sci. U.S.A. 105(25):8795-800. DOI: 10.1073/pnas.0802493105

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Andersen, S.U., Buechel, S., Zhao, Z., Ljung, K., Novák, O., Busch, W., Schuster, C., Lohmann, J.U. Requirement of B2-type cyclin-dependent kinases for meristem integrity in Arabidopsis thaliana. (2008) Plant Cell. 20(1):88-100. DOI: 10.1105/tpc.107.054676

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Busch, W., Lohmann, J.U. Profiling a plant: expression analysis in Arabidopsis. (2007) Curr. Opin. Plant Biol. 10(2):136-41. DOI: 10.1016/j.pbi.2007.01.002

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Levesque, M.P., Vernoux, T., Busch, W., Cui, H., Wang, J.Y., Blilou, I., Hassan, H., Nakajima, K., Matsumoto, N., Lohmann, J.U., Scheres, B., Benfey, P.N. Whole-genome analysis of the SHORT-ROOT developmental pathway in Arabidopsis. (2006) PLoS Biol. 4(5):e143. DOI: 10.1371/journal.pbio.0040143

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Leibfried, A., To, J.P., Busch, W., Stehling, S., Kehle, A., Demar, M., Kieber, J.J., Lohmann, J.U. WUSCHEL controls meristem function by direct regulation of cytokinin-inducible response regulators. (2005) Nature. 438(7071):1172-5. DOI: 10.1038/nature04270

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Wigge, P.A., Kim, M.C., Jaeger, K.E., Busch, W., Schmid, M., Lohmann, J.U., Weigel, D. Integration of spatial and temporal information during floral induction in Arabidopsis. (2005) Science. 309(5737):1056-9. DOI: 10.1126/science.1114358

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Busch, W., Wunderlich, M., Schöffl, F. Identification of novel heat shock factor-dependent genes and biochemical pathways in Arabidopsis thaliana. (2005) Plant J. 41(1):1-14. DOI: 10.1111/j.1365-313X.2004.02272.x

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Busch, W., Saier, M.H., . The IUBMB-endorsed transporter classification system. (2004) Mol. Biotechnol. 27(3):253-62.

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Pivetti, C.D., Yen, M.R., Miller, S., Busch, W., Tseng, Y.H., Booth, I.R., Saier, M.H. Two families of mechanosensitive channel proteins. (2003) Microbiol. Mol. Biol. Rev. 67(1):66-85, table of contents.

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Busch, W., Saier, M.H. The IUBMB-endorsed transporter classification system. (2003) Methods Mol. Biol. 227:21-36. DOI: 10.1385/1-59259-387-9:21


Busch, W., Saier, M.H. The transporter classification (TC) system, 2002. (2002) Crit. Rev. Biochem. Mol. Biol. 37(5):287-337. DOI: 10.1080/10409230290771528

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Education

Diploma, Biology, University of Tübingen, Germany 2004
PhD, Biology, University of Tübingen, Germany 2009


Awards & Honors

  • 2015 Society for Experimental Biology President's Medal 2015
  • 2014 Annals of Botany Lecture; ICAR 2014; Vancouver; Canada

  • 2013 Genome Web Young Investigator, GenomeWeb Intelligence Network, USA
  • 2009 Doctoral thesis award, Reinhold-und-Maria-T eufel Foundation, Germany
  • 2008 PhD summa cum laude, University of Tübingen, Germany
  • 2004 PhD - Fellowship of the Cusanuswerk, Germany


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