Martin Hetzer

Vice President, Chief Science Officer

Professor

Molecular and Cell Biology Laboratory

Jesse and Caryl Philips Foundation Chair

Salk Institute for Biological Studies - Publications

selected Publications


Franks, T.M., McCloskey, A., Shokirev, M., Benner, C., Rathore, A., Hetzer, M.W. Nup98 recruits the Wdr82-Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. (2017) Genes Dev. 31(22):2222-2234. DOI: 10.1101/gad.306753.117

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Buchwalter, A., Hetzer, M.W. Nucleolar expansion and elevated protein translation in premature aging. (2017) Nat Commun. 8(1):328. DOI: 10.1038/s41467-017-00322-z

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Ibarra, A., Benner, C., Tyagi, S., Cool, J., Hetzer, M.W. Nucleoporin-mediated regulation of cell identity genes. (2016) Genes Dev. 30(20):2253-2258. DOI: 10.1101/gad.287417.116

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Franks, T.M., Benner, C., Narvaiza, I., Marchetto, M.C., Young, J.M., Malik, H.S., Gage, F.H., Hetzer, M.W. Evolution of a transcriptional regulator from a transmembrane nucleoporin. (2016) Genes Dev. 30(10):1155-71. DOI: 10.1101/gad.280941.116

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Toyama, B.H., Savas, J.N., Park, S.K., Harris, M.S., Ingolia, N.T., Yates, J.R., Hetzer, M.W. Identification of long-lived proteins reveals exceptional stability of essential cellular structures. (2013) Cell. 154(5):971-982. DOI: 10.1016/j.cell.2013.07.037

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Hatch, E.M., Fischer, A.H., Deerinck, T.J., Hetzer, M.W. Catastrophic nuclear envelope collapse in cancer cell micronuclei. (2013) Cell. 154(1):47-60. DOI: 10.1016/j.cell.2013.06.007

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Doucet, C.M., Talamas, J.A., Hetzer, M.W. Cell cycle-dependent differences in nuclear pore complex assembly in metazoa. (2010) Cell. 141(6):1030-41. DOI: 10.1016/j.cell.2010.04.036

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Capelson, M., Liang, Y., Schulte, R., Mair, W., Wagner, U., Hetzer, M.W. Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. (2010) Cell. 140(3):372-83. DOI: 10.1016/j.cell.2009.12.054

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D'Angelo, M.A., Raices, M., Panowski, S.H., Hetzer, M.W. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. (2009) Cell. 136(2):284-95. DOI: 10.1016/j.cell.2008.11.037

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all Publications


Franks, T.M., McCloskey, A., Shokirev, M., Benner, C., Rathore, A., Hetzer, M.W. Nup98 recruits the Wdr82-Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. (2017) Genes Dev. 31(22):2222-2234. DOI: 10.1101/gad.306753.117

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Toda, T., Hsu, J.Y., Linker, S.B., Hu, L., Schafer, S.T., Mertens, J., Jacinto, F.V., Hetzer, M.W., Gage, F.H. Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells. (2017) Cell Stem Cell. DOI: 10.1016/j.stem.2017.08.012

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Buchwalter, A., Hetzer, M.W. Nucleolar expansion and elevated protein translation in premature aging. (2017) Nat Commun. 8(1):328. DOI: 10.1038/s41467-017-00322-z

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van de Ven, R.A., de Groot, J.S., Park, D., van Domselaar, R., de Jong, D., Szuhai, K., van der Wall, E., Rueda, O.M., Ali, H.R., Caldas, C., van Diest, P.J., Hetzer, M.W., Sahai, E., Derksen, P.W. p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis. (2016) Nat Commun. 7:13874. DOI: 10.1038/ncomms13874

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Ibarra, A., Benner, C., Tyagi, S., Cool, J., Hetzer, M.W. Nucleoporin-mediated regulation of cell identity genes. (2016) Genes Dev. 30(20):2253-2258. DOI: 10.1101/gad.287417.116

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Hatch, E.M., Hetzer, M.W. Nuclear envelope rupture is induced by actin-based nucleus confinement. (2016) J. Cell Biol. 215(1):27-36. DOI: 10.1083/jcb.201603053

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Franks, T.M., Benner, C., Narvaiza, I., Marchetto, M.C., Young, J.M., Malik, H.S., Gage, F.H., Hetzer, M.W. Evolution of a transcriptional regulator from a transmembrane nucleoporin. (2016) Genes Dev. 30(10):1155-71. DOI: 10.1101/gad.280941.116

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Mertens, J., Paquola, A.C., Ku, M., Hatch, E., Böhnke, L., Ladjevardi, S., McGrath, S., Campbell, B., Lee, H., Herdy, J.R., Gonçalves, J.T., Toda, T., Kim, Y., Winkler, J., Yao, J., Hetzer, M.W., Gage, F.H. Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. (2015) Cell Stem Cell. 17(6):705-18. DOI: 10.1016/j.stem.2015.09.001

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Ori, A., Toyama, B.H., Harris, M.S., Bock, T., Iskar, M., Bork, P., Ingolia, N.T., Hetzer, M.W., Beck, M. Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats. (2015) Cell Syst. 1(3):224-37. DOI: 10.1016/j.cels.2015.08.012

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Hatch, E.M., Hetzer, M.W. Linking Micronuclei to Chromosome Fragmentation. (2015) Cell. 161(7):1502-4. DOI: 10.1016/j.cell.2015.06.005

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Jacinto, F.V., Benner, C., Hetzer, M.W. The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. (2015) Genes Dev. 29(12):1224-38. DOI: 10.1101/gad.260919.115

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Hatch, E.M., Hetzer, M.W. Chromothripsis. (2015) Curr. Biol. 25(10):R397-9. DOI: 10.1016/j.cub.2015.02.033


Gomez-Cavazos, J.S., Hetzer, M.W. The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. (2015) J. Cell Biol. 208(6):671-81. DOI: 10.1083/jcb.201410047

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Ibarra, A., Hetzer, M.W. Nuclear pore proteins and the control of genome functions. (2015) Genes Dev. 29(4):337-49. DOI: 10.1101/gad.256495.114

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Buchwalter, A.L., Liang, Y., Hetzer, M.W. Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. (2014) Mol. Biol. Cell. 25(16):2472-84. DOI: 10.1091/mbc.E14-04-0865

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Hatch, E., Hetzer, M. Breaching the nuclear envelope in development and disease. (2014) J. Cell Biol. 205(2):133-41. DOI: 10.1083/jcb.201402003

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Buchwalter, A., Hetzer, M.W. Nuclear pores set the speed limit for mitosis. (2014) Cell. 156(5):868-9. DOI: 10.1016/j.cell.2014.02.004

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Toyama, B.H., Savas, J.N., Park, S.K., Harris, M.S., Ingolia, N.T., Yates, J.R., Hetzer, M.W. Identification of long-lived proteins reveals exceptional stability of essential cellular structures. (2013) Cell. 154(5):971-982. DOI: 10.1016/j.cell.2013.07.037

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Hatch, E.M., Fischer, A.H., Deerinck, T.J., Hetzer, M.W. Catastrophic nuclear envelope collapse in cancer cell micronuclei. (2013) Cell. 154(1):47-60. DOI: 10.1016/j.cell.2013.06.007

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Regner, B.M., Vučinić, D., Domnisoru, C., Bartol, T.M., Hetzer, M.W., Tartakovsky, D.M., Sejnowski, T.J. Anomalous diffusion of single particles in cytoplasm. (2013) Biophys. J. 104(8):1652-60. DOI: 10.1016/j.bpj.2013.01.049

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Franks, T.M., Hetzer, M.W. The role of Nup98 in transcription regulation in healthy and diseased cells. (2013) Trends Cell Biol. 23(3):112-7. DOI: 10.1016/j.tcb.2012.10.013

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Liang, Y., Franks, T.M., Marchetto, M.C., Gage, F.H., Hetzer, M.W. Dynamic association of NUP98 with the human genome. (2013) PLoS Genet. 9(2):e1003308. DOI: 10.1371/journal.pgen.1003308

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Toyama, B.H., Hetzer, M.W. Protein homeostasis: live long, won't prosper. (2013) Nat. Rev. Mol. Cell Biol. 14(1):55-61. DOI: 10.1038/nrm3496

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Gomez-Cavazos, J.S., Hetzer, M.W. Outfits for different occasions: tissue-specific roles of Nuclear Envelope proteins. (2012) Curr. Opin. Cell Biol. 24(6):775-83. DOI: 10.1016/j.ceb.2012.08.008

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Hatch, E.M., Hetzer, M.W. RNP export by nuclear envelope budding. (2012) Cell. 149(4):733-5. DOI: 10.1016/j.cell.2012.04.018

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D'Angelo, M.A., Gomez-Cavazos, J.S., Mei, A., Lackner, D.H., Hetzer, M.W. A change in nuclear pore complex composition regulates cell differentiation. (2012) Dev. Cell. 22(2):446-58. DOI: 10.1016/j.devcel.2011.11.021

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Savas, J.N., Toyama, B.H., Xu, T., Yates, J.R., Hetzer, M.W. Extremely long-lived nuclear pore proteins in the rat brain. (2012) Science. 335(6071):942. DOI: 10.1126/science.1217421

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Vargas, J.D., Hatch, E.M., Anderson, D.J., Hetzer, M.W. Transient nuclear envelope rupturing during interphase in human cancer cells. (2012) Nucleus. 3(1):88-100. DOI: 10.4161/nucl.18954

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Talamas, J.A., Hetzer, M.W. POM121 and Sun1 play a role in early steps of interphase NPC assembly. (2011) J. Cell Biol. 194(1):27-37. DOI: 10.1083/jcb.201012154

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Hetzer, M., Cavalli, G. Eukaryotic cells. (2011) Curr. Opin. Cell Biol. 23(3):255-7. DOI: 10.1016/j.ceb.2011.04.013


Liang, Y., Hetzer, M.W. Functional interactions between nucleoporins and chromatin. (2011) Curr. Opin. Cell Biol. 23(1):65-70. DOI: 10.1016/j.ceb.2010.09.008

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Doucet, C.M., Hetzer, M.W. Nuclear pore biogenesis into an intact nuclear envelope. (2010) Chromosoma. 119(5):469-77. DOI: 10.1007/s00412-010-0289-2

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Hetzer, M. Martin Hetzer: taking the nuclear membrane beyond the barrier. (2010) J. Cell Biol. 190(4):484-5. DOI: 10.1083/jcb.1904pi


Doucet, C.M., Talamas, J.A., Hetzer, M.W. Cell cycle-dependent differences in nuclear pore complex assembly in metazoa. (2010) Cell. 141(6):1030-41. DOI: 10.1016/j.cell.2010.04.036

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Capelson, M., Doucet, C., Hetzer, M.W. Nuclear pore complexes: guardians of the nuclear genome. (2010) Cold Spring Harb. Symp. Quant. Biol. 75:585-97. DOI: 10.1101/sqb.2010.75.059

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Hetzer, M.W. The role of the nuclear pore complex in aging of post-mitotic cells. (2010) Aging (Albany NY). 2(2):74-5. DOI: 10.18632/aging.100125


Hetzer, M.W. The nuclear envelope. (2010) Cold Spring Harb Perspect Biol. 2(3):a000539. DOI: 10.1101/cshperspect.a000539

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Capelson, M., Liang, Y., Schulte, R., Mair, W., Wagner, U., Hetzer, M.W. Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. (2010) Cell. 140(3):372-83. DOI: 10.1016/j.cell.2009.12.054

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Hetzer, M.W., Wente, S.R. Border control at the nucleus: biogenesis and organization of the nuclear membrane and pore complexes. (2009) Dev. Cell. 17(5):606-16. DOI: 10.1016/j.devcel.2009.10.007

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Anderson, D.J., Vargas, J.D., Hsiao, J.P., Hetzer, M.W. Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo. (2009) J. Cell Biol. 186(2):183-91. DOI: 10.1083/jcb.200901106

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Capelson, M., Hetzer, M.W. The role of nuclear pores in gene regulation, development and disease. (2009) EMBO Rep. 10(7):697-705. DOI: 10.1038/embor.2009.147

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Dawson, T.R., Lazarus, M.D., Hetzer, M.W., Wente, S.R. ER membrane-bending proteins are necessary for de novo nuclear pore formation. (2009) J. Cell Biol. 184(5):659-75. DOI: 10.1083/jcb.200806174

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D'Angelo, M.A., Raices, M., Panowski, S.H., Hetzer, M.W. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. (2009) Cell. 136(2):284-95. DOI: 10.1016/j.cell.2008.11.037

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Kutay, U., Hetzer, M.W. Reorganization of the nuclear envelope during open mitosis. (2008) Curr. Opin. Cell Biol. 20(6):669-77. DOI: 10.1016/j.ceb.2008.09.010

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D'Angelo, M.A., Hetzer, M.W. Structure, dynamics and function of nuclear pore complexes. (2008) Trends Cell Biol. 18(10):456-66. DOI: 10.1016/j.tcb.2008.07.009

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Anderson, D.J., Hetzer, M.W. Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation. (2008) J. Cell Biol. 182(5):911-24. DOI: 10.1083/jcb.200805140

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Anderson, D.J., Hetzer, M.W. The life cycle of the metazoan nuclear envelope. (2008) Curr. Opin. Cell Biol. 20(4):386-92. DOI: 10.1016/j.ceb.2008.03.016

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Schulte, R., Talamas, J., Doucet, C., Hetzer, M.W. Single bead affinity detection (SINBAD) for the analysis of protein-protein interactions. (2008) PLoS ONE. 3(4):e2061. DOI: 10.1371/journal.pone.0002061

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Anderson, D.J., Hetzer, M.W. Shaping the endoplasmic reticulum into the nuclear envelope. (2008) J. Cell. Sci. 121(Pt 2):137-42. DOI: 10.1242/jcs.005777

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Anderson, D.J., Hetzer, M.W. Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulum. (2007) Nat. Cell Biol. 9(10):1160-6. DOI: 10.1038/ncb1636

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Franz, C., Walczak, R., Yavuz, S., Santarella, R., Gentzel, M., Askjaer, P., Galy, V., Hetzer, M., Mattaj, I.W., Antonin, W. MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. (2007) EMBO Rep. 8(2):165-72. DOI: 10.1038/sj.embor.7400889

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D'Angelo, M.A., Anderson, D.J., Richard, E., Hetzer, M.W. Nuclear pores form de novo from both sides of the nuclear envelope. (2006) Science. 312(5772):440-3. DOI: 10.1126/science.1124196

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D'Angelo, M.A., Hetzer, M.W. The role of the nuclear envelope in cellular organization. (2006) Cell. Mol. Life Sci. 63(3):316-32. DOI: 10.1007/s00018-005-5361-3

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Hetzer, M.W., Walther, T.C., Mattaj, I.W. Pushing the envelope: structure, function, and dynamics of the nuclear periphery. (2005) Annu. Rev. Cell Dev. Biol. 21:347-80. DOI: 10.1146/annurev.cellbio.21.090704.151152

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Walther, T.C., Askjaer, P., Gentzel, M., Habermann, A., Griffiths, G., Wilm, M., Mattaj, I.W., Hetzer, M. RanGTP mediates nuclear pore complex assembly. (2003) Nature. 424(6949):689-94. DOI: 10.1038/nature01898

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Walther, T.C., Alves, A., Pickersgill, H., Loïodice, I., Hetzer, M., Galy, V., Hülsmann, B.B., Köcher, T., Wilm, M., Allen, T., Mattaj, I.W., Doye, V. The conserved Nup107-160 complex is critical for nuclear pore complex assembly. (2003) Cell. 113(2):195-206. DOI: 10.1016/S0092-8674(03)00235-6

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Bilbao-Cortés, D., Hetzer, M., Längst, G., Becker, P.B., Mattaj, I.W. Ran binds to chromatin by two distinct mechanisms. (2002) Curr. Biol. 12(13):1151-6.

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Hetzer, M., Gruss, O.J., Mattaj, I.W. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. (2002) Nat. Cell Biol. 4(7):E177-84. DOI: 10.1038/ncb0702-e177

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Education

Undergraduate degree, University of Vienna, Austria
PhD, Biochemistry and Genetics, Vienna Biocenter, Austria
Postdoctoral work at EMBL, Heidelberg, Germany


Awards & Honors

  • 2015 National Institutes of Health (NIH) Transformative Research Award
  • 2013 Glenn Award for Research in Biological Mechanisms of Aging
  • 2009 ASCINA Award (Austrian Scientists and Scholars in North America)
  • 2009 Early Career Life Science Award, American Society of Cell Biology
  • 2009-2013 Ellison Medical Foundation Senior Scholar in Aging
  • 2009-2013 American Cancer Society Research Scholar
  • 2005 Pew Scholar
  • 2000-2003 APART fellow
  • 1998-2003 EMBO long term fellowship
  • 1997 Austrian science award in Genetics
  • 1997 Erwin Schroedinger fellowship