Martin Hetzer

Vice President, Chief Science Officer
Professor
Molecular and Cell Biology Laboratory
Jesse and Caryl Philips Foundation Chair

Salk Institute for Biological Studies - Publications

selected Publications


Arrojo E Drigo, R., Lev-Ram, V., Tyagi, S., Ramachandra, R., Deerinck, T., Bushong, E., Phan, S., Orphan, V., Lechene, C., Ellisman, M.H., Hetzer, M.W. Age Mosaicism across Multiple Scales in Adult Tissues. (2019) Cell Metabolism. DOI: 10.1016/j.cmet.2019.05.010

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McCloskey, A., Ibarra, A., Hetzer, M.W. Tpr regulates the total number of nuclear pore complexes per cell nucleus. (2018) Genes & Development. DOI: 10.1101/gad.315523.118

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Franks, T.M., McCloskey, A., Shokirev, M., Benner, C., Rathore, A., Hetzer, M.W. Nup98 recruits the Wdr82-Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. (2017) Genes & Development. 31(22):2222-2234. DOI: 10.1101/gad.306753.117

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Buchwalter, A., Hetzer, M.W. Nucleolar expansion and elevated protein translation in premature aging. (2017) Nature Communications. 8(1):328. DOI: 10.1038/s41467-017-00322-z

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Ibarra, A., Benner, C., Tyagi, S., Cool, J., Hetzer, M.W. Nucleoporin-mediated regulation of cell identity genes. (2016) Genes & Development. 30(20):2253-2258. DOI: 10.1101/gad.287417.116

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Franks, T.M., Benner, C., Narvaiza, I., Marchetto, M.C., Young, J.M., Malik, H.S., Gage, F.H., Hetzer, M.W. Evolution of a transcriptional regulator from a transmembrane nucleoporin. (2016) Genes & Development. 30(10):1155-71. DOI: 10.1101/gad.280941.116

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Toyama, B.H., Savas, J.N., Park, S.K., Harris, M.S., Ingolia, N.T., Yates, J.R., Hetzer, M.W. Identification of long-lived proteins reveals exceptional stability of essential cellular structures. (2013) Cell. 154(5):971-982. DOI: 10.1016/j.cell.2013.07.037

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Hatch, E.M., Fischer, A.H., Deerinck, T.J., Hetzer, M.W. Catastrophic nuclear envelope collapse in cancer cell micronuclei. (2013) Cell. 154(1):47-60. DOI: 10.1016/j.cell.2013.06.007

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Doucet, C.M., Talamas, J.A., Hetzer, M.W. Cell cycle-dependent differences in nuclear pore complex assembly in metazoa. (2010) Cell. 141(6):1030-41. DOI: 10.1016/j.cell.2010.04.036

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Capelson, M., Liang, Y., Schulte, R., Mair, W., Wagner, U., Hetzer, M.W. Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. (2010) Cell. 140(3):372-83. DOI: 10.1016/j.cell.2009.12.054

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D'Angelo, M.A., Raices, M., Panowski, S.H., Hetzer, M.W. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. (2009) Cell. 136(2):284-95. DOI: 10.1016/j.cell.2008.11.037

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all Publications


Arrojo E Drigo, R., Lev-Ram, V., Tyagi, S., Ramachandra, R., Deerinck, T., Bushong, E., Phan, S., Orphan, V., Lechene, C., Ellisman, M.H., Hetzer, M.W. Age Mosaicism across Multiple Scales in Adult Tissues. (2019) Cell Metabolism. DOI: 10.1016/j.cmet.2019.05.010

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Toyama, B.H., Arrojo E Drigo, R., Lev-Ram, V., Ramachandra, R., Deerinck, T.J., Lechene, C., Ellisman, M.H., Hetzer, M.W. Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells. (2018) Journal of Cell Biology. DOI: 10.1083/jcb.201809123

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Fleischer, J.G., Schulte, R., Tsai, H.H., Tyagi, S., Ibarra, A., Shokhirev, M.N., Huang, L., Hetzer, M.W., Navlakha, S. Predicting age from the transcriptome of human dermal fibroblasts. (2018) Genome Biology. 19(1):221. DOI: 10.1186/s13059-018-1599-6

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Buchwalter, A., Kaneshiro, J.M., Hetzer, M.W. Coaching from the sidelines: the nuclear periphery in genome regulation. (2018) Nature Reviews. Genetics. DOI: 10.1038/s41576-018-0063-5

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McCloskey, A., Ibarra, A., Hetzer, M.W. Tpr regulates the total number of nuclear pore complexes per cell nucleus. (2018) Genes & Development. DOI: 10.1101/gad.315523.118

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Franks, T.M., McCloskey, A., Shokirev, M., Benner, C., Rathore, A., Hetzer, M.W. Nup98 recruits the Wdr82-Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. (2017) Genes & Development. 31(22):2222-2234. DOI: 10.1101/gad.306753.117

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Toda, T., Hsu, J.Y., Linker, S.B., Hu, L., Schafer, S.T., Mertens, J., Jacinto, F.V., Hetzer, M.W., Gage, F.H. Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells. (2017) Cell Stem Cell. DOI: 10.1016/j.stem.2017.08.012

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Buchwalter, A., Hetzer, M.W. Nucleolar expansion and elevated protein translation in premature aging. (2017) Nature Communications. 8(1):328. DOI: 10.1038/s41467-017-00322-z

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van de Ven, R.A., de Groot, J.S., Park, D., van Domselaar, R., de Jong, D., Szuhai, K., van der Wall, E., Rueda, O.M., Ali, H.R., Caldas, C., van Diest, P.J., Hetzer, M.W., Sahai, E., Derksen, P.W. p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis. (2016) Nature Communications. 7:13874. DOI: 10.1038/ncomms13874

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Ibarra, A., Benner, C., Tyagi, S., Cool, J., Hetzer, M.W. Nucleoporin-mediated regulation of cell identity genes. (2016) Genes & Development. 30(20):2253-2258. DOI: 10.1101/gad.287417.116

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Hatch, E.M., Hetzer, M.W. Nuclear envelope rupture is induced by actin-based nucleus confinement. (2016) Journal of Cell Biology. 215(1):27-36. DOI: 10.1083/jcb.201603053

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Franks, T.M., Benner, C., Narvaiza, I., Marchetto, M.C., Young, J.M., Malik, H.S., Gage, F.H., Hetzer, M.W. Evolution of a transcriptional regulator from a transmembrane nucleoporin. (2016) Genes & Development. 30(10):1155-71. DOI: 10.1101/gad.280941.116

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Mertens, J., Paquola, A.C., Ku, M., Hatch, E., Böhnke, L., Ladjevardi, S., McGrath, S., Campbell, B., Lee, H., Herdy, J.R., Gonçalves, J.T., Toda, T., Kim, Y., Winkler, J., Yao, J., Hetzer, M.W., Gage, F.H. Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. (2015) Cell Stem Cell. 17(6):705-18. DOI: 10.1016/j.stem.2015.09.001

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Ori, A., Toyama, B.H., Harris, M.S., Bock, T., Iskar, M., Bork, P., Ingolia, N.T., Hetzer, M.W., Beck, M. Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats. (2015) Cell Systems. 1(3):224-37. DOI: 10.1016/j.cels.2015.08.012

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Hatch, E.M., Hetzer, M.W. Linking Micronuclei to Chromosome Fragmentation. (2015) Cell. 161(7):1502-4. DOI: 10.1016/j.cell.2015.06.005

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Jacinto, F.V., Benner, C., Hetzer, M.W. The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. (2015) Genes & Development. 29(12):1224-38. DOI: 10.1101/gad.260919.115

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Hatch, E.M., Hetzer, M.W. Chromothripsis. (2015) Current Biology. 25(10):R397-9. DOI: 10.1016/j.cub.2015.02.033


Gomez-Cavazos, J.S., Hetzer, M.W. The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. (2015) Journal of Cell Biology. 208(6):671-81. DOI: 10.1083/jcb.201410047

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Ibarra, A., Hetzer, M.W. Nuclear pore proteins and the control of genome functions. (2015) Genes & Development. 29(4):337-49. DOI: 10.1101/gad.256495.114

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Buchwalter, A.L., Liang, Y., Hetzer, M.W. Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. (2014) Molecular Biology of the Cell. 25(16):2472-84. DOI: 10.1091/mbc.E14-04-0865

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Hatch, E., Hetzer, M. Breaching the nuclear envelope in development and disease. (2014) Journal of Cell Biology. 205(2):133-41. DOI: 10.1083/jcb.201402003

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Buchwalter, A., Hetzer, M.W. Nuclear pores set the speed limit for mitosis. (2014) Cell. 156(5):868-9. DOI: 10.1016/j.cell.2014.02.004

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Toyama, B.H., Savas, J.N., Park, S.K., Harris, M.S., Ingolia, N.T., Yates, J.R., Hetzer, M.W. Identification of long-lived proteins reveals exceptional stability of essential cellular structures. (2013) Cell. 154(5):971-982. DOI: 10.1016/j.cell.2013.07.037

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Hatch, E.M., Fischer, A.H., Deerinck, T.J., Hetzer, M.W. Catastrophic nuclear envelope collapse in cancer cell micronuclei. (2013) Cell. 154(1):47-60. DOI: 10.1016/j.cell.2013.06.007

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Regner, B.M., Vučinić, D., Domnisoru, C., Bartol, T.M., Hetzer, M.W., Tartakovsky, D.M., Sejnowski, T.J. Anomalous diffusion of single particles in cytoplasm. (2013) Biophysical Journal. 104(8):1652-60. DOI: 10.1016/j.bpj.2013.01.049

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Franks, T.M., Hetzer, M.W. The role of Nup98 in transcription regulation in healthy and diseased cells. (2013) Trends in Cell Biology. 23(3):112-7. DOI: 10.1016/j.tcb.2012.10.013

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Liang, Y., Franks, T.M., Marchetto, M.C., Gage, F.H., Hetzer, M.W. Dynamic association of NUP98 with the human genome. (2013) PLOS Genetics. 9(2):e1003308. DOI: 10.1371/journal.pgen.1003308

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Toyama, B.H., Hetzer, M.W. Protein homeostasis: live long, won't prosper. (2013) Nature Reviews. Molecular Cell Biology. 14(1):55-61. DOI: 10.1038/nrm3496

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Gomez-Cavazos, J.S., Hetzer, M.W. Outfits for different occasions: tissue-specific roles of Nuclear Envelope proteins. (2012) Current Opinion in Cell Biology. 24(6):775-83. DOI: 10.1016/j.ceb.2012.08.008

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Hatch, E.M., Hetzer, M.W. RNP export by nuclear envelope budding. (2012) Cell. 149(4):733-5. DOI: 10.1016/j.cell.2012.04.018

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D'Angelo, M.A., Gomez-Cavazos, J.S., Mei, A., Lackner, D.H., Hetzer, M.W. A change in nuclear pore complex composition regulates cell differentiation. (2012) Developmental Cell. 22(2):446-58. DOI: 10.1016/j.devcel.2011.11.021

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Savas, J.N., Toyama, B.H., Xu, T., Yates, J.R., Hetzer, M.W. Extremely long-lived nuclear pore proteins in the rat brain. (2012) Science. 335(6071):942. DOI: 10.1126/science.1217421

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Vargas, J.D., Hatch, E.M., Anderson, D.J., Hetzer, M.W. Transient nuclear envelope rupturing during interphase in human cancer cells. (2012) Nucleus. 3(1):88-100. DOI: 10.4161/nucl.18954

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Talamas, J.A., Hetzer, M.W. POM121 and Sun1 play a role in early steps of interphase NPC assembly. (2011) Journal of Cell Biology. 194(1):27-37. DOI: 10.1083/jcb.201012154

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Hetzer, M., Cavalli, G. Eukaryotic cells. (2011) Current Opinion in Cell Biology. 23(3):255-7. DOI: 10.1016/j.ceb.2011.04.013


Liang, Y., Hetzer, M.W. Functional interactions between nucleoporins and chromatin. (2011) Current Opinion in Cell Biology. 23(1):65-70. DOI: 10.1016/j.ceb.2010.09.008

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Doucet, C.M., Hetzer, M.W. Nuclear pore biogenesis into an intact nuclear envelope. (2010) Chromosoma. 119(5):469-77. DOI: 10.1007/s00412-010-0289-2

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Hetzer, M. Martin Hetzer: taking the nuclear membrane beyond the barrier. (2010) Journal of Cell Biology. 190(4):484-5. DOI: 10.1083/jcb.1904pi


Doucet, C.M., Talamas, J.A., Hetzer, M.W. Cell cycle-dependent differences in nuclear pore complex assembly in metazoa. (2010) Cell. 141(6):1030-41. DOI: 10.1016/j.cell.2010.04.036

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Capelson, M., Doucet, C., Hetzer, M.W. Nuclear pore complexes: guardians of the nuclear genome. (2010) Cold Spring Harbor Symposia on Quantitative Biology. 75:585-97. DOI: 10.1101/sqb.2010.75.059

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Hetzer, M.W. The role of the nuclear pore complex in aging of post-mitotic cells. (2010) Aging (Albany NY). 2(2):74-5. DOI: 10.18632/aging.100125


Hetzer, M.W. The nuclear envelope. (2010) Cold Spring Harbor Perspectives in Biology. 2(3):a000539. DOI: 10.1101/cshperspect.a000539

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Capelson, M., Liang, Y., Schulte, R., Mair, W., Wagner, U., Hetzer, M.W. Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. (2010) Cell. 140(3):372-83. DOI: 10.1016/j.cell.2009.12.054

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Hetzer, M.W., Wente, S.R. Border control at the nucleus: biogenesis and organization of the nuclear membrane and pore complexes. (2009) Developmental Cell. 17(5):606-16. DOI: 10.1016/j.devcel.2009.10.007

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Anderson, D.J., Vargas, J.D., Hsiao, J.P., Hetzer, M.W. Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo. (2009) Journal of Cell Biology. 186(2):183-91. DOI: 10.1083/jcb.200901106

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Capelson, M., Hetzer, M.W. The role of nuclear pores in gene regulation, development and disease. (2009) EMBO Reports. 10(7):697-705. DOI: 10.1038/embor.2009.147

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Dawson, T.R., Lazarus, M.D., Hetzer, M.W., Wente, S.R. ER membrane-bending proteins are necessary for de novo nuclear pore formation. (2009) Journal of Cell Biology. 184(5):659-75. DOI: 10.1083/jcb.200806174

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D'Angelo, M.A., Raices, M., Panowski, S.H., Hetzer, M.W. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. (2009) Cell. 136(2):284-95. DOI: 10.1016/j.cell.2008.11.037

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Kutay, U., Hetzer, M.W. Reorganization of the nuclear envelope during open mitosis. (2008) Current Opinion in Cell Biology. 20(6):669-77. DOI: 10.1016/j.ceb.2008.09.010

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D'Angelo, M.A., Hetzer, M.W. Structure, dynamics and function of nuclear pore complexes. (2008) Trends in Cell Biology. 18(10):456-66. DOI: 10.1016/j.tcb.2008.07.009

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Anderson, D.J., Hetzer, M.W. Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation. (2008) Journal of Cell Biology. 182(5):911-24. DOI: 10.1083/jcb.200805140

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Anderson, D.J., Hetzer, M.W. The life cycle of the metazoan nuclear envelope. (2008) Current Opinion in Cell Biology. 20(4):386-92. DOI: 10.1016/j.ceb.2008.03.016

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Schulte, R., Talamas, J., Doucet, C., Hetzer, M.W. Single bead affinity detection (SINBAD) for the analysis of protein-protein interactions. (2008) PLOS One. 3(4):e2061. DOI: 10.1371/journal.pone.0002061

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Anderson, D.J., Hetzer, M.W. Shaping the endoplasmic reticulum into the nuclear envelope. (2008) Journal of Cell Science. 121(Pt 2):137-42. DOI: 10.1242/jcs.005777

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Anderson, D.J., Hetzer, M.W. Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulum. (2007) Nature Cell Biology. 9(10):1160-6. DOI: 10.1038/ncb1636

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Franz, C., Walczak, R., Yavuz, S., Santarella, R., Gentzel, M., Askjaer, P., Galy, V., Hetzer, M., Mattaj, I.W., Antonin, W. MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. (2007) EMBO Reports. 8(2):165-72. DOI: 10.1038/sj.embor.7400889

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D'Angelo, M.A., Anderson, D.J., Richard, E., Hetzer, M.W. Nuclear pores form de novo from both sides of the nuclear envelope. (2006) Science. 312(5772):440-3. DOI: 10.1126/science.1124196

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D'Angelo, M.A., Hetzer, M.W. The role of the nuclear envelope in cellular organization. (2006) Cellular and Molecular Life Sciences. 63(3):316-32. DOI: 10.1007/s00018-005-5361-3

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Hetzer, M.W., Walther, T.C., Mattaj, I.W. Pushing the envelope: structure, function, and dynamics of the nuclear periphery. (2005) Annual Review of Cell and Developmental Biology. 21:347-80. DOI: 10.1146/annurev.cellbio.21.090704.151152

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Walther, T.C., Askjaer, P., Gentzel, M., Habermann, A., Griffiths, G., Wilm, M., Mattaj, I.W., Hetzer, M. RanGTP mediates nuclear pore complex assembly. (2003) Nature. 424(6949):689-94. DOI: 10.1038/nature01898

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Walther, T.C., Alves, A., Pickersgill, H., Loïodice, I., Hetzer, M., Galy, V., Hülsmann, B.B., Köcher, T., Wilm, M., Allen, T., Mattaj, I.W., Doye, V. The conserved Nup107-160 complex is critical for nuclear pore complex assembly. (2003) Cell. 113(2):195-206. DOI: 10.1016/S0092-8674(03)00235-6

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Bilbao-Cortés, D., Hetzer, M., Längst, G., Becker, P.B., Mattaj, I.W. Ran binds to chromatin by two distinct mechanisms. (2002) Current Biology. 12(13):1151-6.

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Hetzer, M., Gruss, O.J., Mattaj, I.W. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. (2002) Nature Cell Biology. 4(7):E177-84. DOI: 10.1038/ncb0702-e177

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Education

Undergraduate degree, University of Vienna, Austria
PhD, Biochemistry and Genetics, Vienna Biocenter, Austria
Postdoctoral work at EMBL, Heidelberg, Germany


Awards & Honors

  • 2015 National Institutes of Health (NIH) Transformative Research Award
  • 2013 Glenn Award for Research in Biological Mechanisms of Aging
  • 2009 ASCINA Award (Austrian Scientists and Scholars in North America)
  • 2009 Early Career Life Science Award, American Society of Cell Biology
  • 2009-2013 Ellison Medical Foundation Senior Scholar in Aging
  • 2009-2013 American Cancer Society Research Scholar
  • 2005 Pew Scholar
  • 2000-2003 APART fellow
  • 1998-2003 EMBO long term fellowship
  • 1997 Austrian science award in Genetics
  • 1997 Erwin Schroedinger fellowship