Julie Law

Assistant Professor

Plant Molecular and Cellular Biology Laboratory

Hearst Foundation Development Chair

Julie Law
Salk Institute for Biological Studies - Publications

all Publications


Zhou, M., Palanca, A.M.S., Law, J.A. Locus-specific control of the de novo DNA methylation pathway in Arabidopsis by the CLASSY family. (2018) Nat. Genet. 50(6). DOI: 10.1038/s41588-018-0115-y

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Li, D., Palanca, A.M.S., Won, S.Y., Gao, L., Feng, Y., Vashisht, A.A., Liu, L., Zhao, Y., Liu, X., Wu, X., Li, S., Le, B., Kim, Y.J., Yang, G., Li, S., Liu, J., Wohlschlegel, J.A., Guo, H., Mo, B., Chen, X., Law, J.A. The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status. (2017) Elife. 6. DOI: 10.7554/eLife.19893

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Zhou, M., Law, J.A. RNA Pol IV and V in gene silencing: Rebel polymerases evolving away from Pol II's rules. (2015) Curr. Opin. Plant Biol. 27:154-64. DOI: 10.1016/j.pbi.2015.07.005

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Law, J.A., Du, J., Hale, C.J., Feng, S., Krajewski, K., Palanca, A.M., Strahl, B.D., Patel, D.J., Jacobsen, S.E. Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. (2013) Nature. 498(7454):385-9. DOI: 10.1038/nature12178

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Zhong, X., Hale, C.J., Law, J.A., Johnson, L.M., Feng, S., Tu, A., Jacobsen, S.E. DDR complex facilitates global association of RNA polymerase V to promoters and evolutionarily young transposons. (2012) Nat. Struct. Mol. Biol. 19(9):870-5. DOI: 10.1038/nsmb.2354

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Law, J.A., Vashisht, A.A., Wohlschlegel, J.A., Jacobsen, S.E. SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV. (2011) PLoS Genet. 7(7):e1002195. DOI: 10.1371/journal.pgen.1002195

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Greenberg, M.V., Ausin, I., Chan, S.W., Cokus, S.J., Cuperus, J.T., Feng, S., Law, J.A., Chu, C., Pellegrini, M., Carrington, J.C., Jacobsen, S.E. Identification of genes required for de novo DNA methylation in Arabidopsis. (2011) Epigenetics. 6(3):344-54.

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Rajakumara, E., Law, J.A., Simanshu, D.K., Voigt, P., Johnson, L.M., Reinberg, D., Patel, D.J., Jacobsen, S.E. A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. (2011) Genes Dev. 25(2):137-52. DOI: 10.1101/gad.1980311

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Guo, L., Yu, Y., Law, J.A., Zhang, X. SET DOMAIN GROUP2 is the major histone H3 lysine [corrected] 4 trimethyltransferase in Arabidopsis. (2010) Proc. Natl. Acad. Sci. U.S.A. 107(43):18557-62. DOI: 10.1073/pnas.1010478107

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Law, J.A., Ausin, I., Johnson, L.M., Vashisht, A.A., Zhu, J.K., Wohlschlegel, J.A., Jacobsen, S.E. A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis. (2010) Curr. Biol. 20(10):951-6. DOI: 10.1016/j.cub.2010.03.062

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Law, J.A., Jacobsen, S.E. Establishing, maintaining and modifying DNA methylation patterns in plants and animals. (2010) Nat. Rev. Genet. 11(3):204-20. DOI: 10.1038/nrg2719

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Law, J.A., Jacobsen, S.E. Molecular biology. Dynamic DNA methylation. (2009) Science. 323(5921):1568-9. DOI: 10.1126/science.1172782


Johnson, L.M., Law, J.A., Khattar, A., Henderson, I.R., Jacobsen, S.E. SRA-domain proteins required for DRM2-mediated de novo DNA methylation. (2008) PLoS Genet. 4(11):e1000280. DOI: 10.1371/journal.pgen.1000280

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Law, J.A., O'Hearn, S.F., Sollner-Webb, B. Trypanosoma brucei RNA editing protein TbMP42 (band VI) is crucial for the endonucleolytic cleavages but not the subsequent steps of U-deletion and U-insertion. (2008) RNA. 14(6):1187-200. DOI: 10.1261/rna.899508

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Law, J.A., O'Hearn, S., Sollner-Webb, B. In Trypanosoma brucei RNA editing, TbMP18 (band VII) is critical for editosome integrity and for both insertional and deletional cleavages. (2007) Mol. Cell. Biol. 27(2):777-87. DOI: 10.1128/MCB.01460-06

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Zhelonkina, A.G., O'Hearn, S.F., Law, J.A., Cruz-Reyes, J., Huang, C.E., Alatortsev, V.S., Sollner-Webb, B. T. brucei RNA editing: action of the U-insertional TUTase within a U-deletion cycle. (2006) RNA. 12(3):476-87. DOI: 10.1261/rna.2243206

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Law, J.A., Huang, C.E., O'Hearn, S.F., Sollner-Webb, B. In Trypanosoma brucei RNA editing, band II enables recognition specifically at each step of the U insertion cycle. (2005) Mol. Cell. Biol. 25(7):2785-94. DOI: 10.1128/MCB.25.7.2785-2794.2005

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Education

PhD Biochemistry, The Johns Hopkins University School of Medicine
BS Magna cum laude Biochemistry and Biophysics, Oregon State University


Awards & Honors

  • 2015 Rita Allen Scholar Award
  • 2007 Ruth L. Kirschstein National Research Service Award, National Institute of Health
  • 2000 Howard Hughes Medical Institute Summer Fellowship, Oregon State University

Profile

Contact

jlaw@salk.edu