Plant Molecular and Cellular Biology Laboratory
Hearst Foundation Development Chair
Zhou, M., Palanca, AM.S. & Law, J.A. 2018. Locus-specific control of the de novo DNA methylation pathway in Arabidopsis by the CLASSY family. Nature Genetics, 10.1038/s41588-018-0115-y.
Law, J.A., Vashisht, A.A., Wohlschlegel, J.A. & Jacobsen, S.E. 2011. SHH1, a Homeodomain Protein Required for DNA Methylation, As Well As RDR2, RDM4, and Chromatin Remodeling Factors, Associate with RNA Polymerase IV. PLoS Genet 7, e1002195.
Rajakumara, E.*, Law, J.A.*, Simanshu, D.K., Voigt, P., Johnson, L.M., Reinberg, D., Patel, D.J., and Jacobsen, S.E. 2011. A dual flip out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo Genes Dev 25(2):137-152.
*The first two authors contributed equally to this publication
Greenberg, M.V., Ausin, I., Chan, S.W., Cokus, S.J., Cuperus, J.T., Feng, S., Law, J.A., Chu, C., Pellegrini, M., Carrington, J.C., and Jacobsen, S.E. 2011. Identification of genes required for de novo DNA methylation in Arabidopsis. Epigenetics 6(3).
Guo, L., Yu, Y., Law, J.A., and Zhang, X. 2010. SET DOMAIN GROUP2 is the major histone H3 lysine 4 trimethyltransferase in Arabidopsis. Proc Natl Acad Sci U S A 107(43): 18557-18562.
Law, J.A., Ausin, I., Johnson, L.M., Vashisht, A.A., Zhu, J.K., Wohlschlegel, J.A., and Jacobsen, S.E. 2010. A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis. Curr Biol 20(10): 951-956.
Law, J.A. and Jacobsen, S.E. 2010. Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nat Rev Genet 11(3): 204-220.
Law, J.A. and Jacobsen, S.E. 2009. Molecular biology. Dynamic DNA methylation. Science 323(5921): 1568-1569.
Johnson, L.M., Law, J.A., Khattar, A., Henderson, I.R., and Jacobsen, S.E. 2008. SRA-domain proteins required for DRM2-mediated de novo DNA methylation. PLoS Genet 4(11): e1000280.
Law, J.A., O'Hearn, S.F., and Sollner-Webb, B. 2008. Trypanosoma brucei RNA editing protein TbMP42 (band VI) is crucial for the endonucleolytic cleavages but not the subsequent steps of U-deletion and U-insertion. RNA 14(6): 1187-1200.
Law, J.A., O'Hearn, S., and Sollner-Webb, B. 2007. In Trypanosoma brucei RNA editing, TbMP18 (band VII) is critical for editosome integrity and for both insertional and deletional cleavages. Mol Cell Biol 27(2): 777-787.
Zhelonkina, A.G., O'Hearn, S.F., Law, J.A., Cruz-Reyes, J., Huang, C.E., Alatortsev, V.S., and Sollner-Webb, B. 2006. T. brucei RNA editing: action of the U-insertional TUTase within a Udeletion cycle. RNA 12(3): 476-487.
Law, J.A., Huang, C.E., O'Hearn, S.F., and Sollner-Webb, B. 2005. In Trypanosoma brucei RNA editing, band II enables recognition specifically at each step of the U insertion cycle. Mol Cell Biol 25(7): 2785-2794.
PhD Biochemistry, The Johns Hopkins University School of Medicine
BS Magna cum laude Biochemistry and Biophysics, Oregon State University