NOMIS Assistant Professor
NOMIS Center for Immunobiology and Microbial Pathogenesis
Qu, Y., Edwards, K., Li, M., Williams, M., Liu, Y., Tsai, P.Y., Cheng, C., Blum, J.E., Acor, N., Oshoe, T., Walter, C., Thirumalaikumar, V., Thalacker-Mercer, A.E., Skirycz, A., Barrow, J. Small Molecule Oxybutynin Rescues Proliferative Capacity of Complex III-Defective Muscle Progenitor Cells. (2025) Am J Physiol Cell Physiol. DOI: 10.1152/ajpcell.00141.2025
Xue, S., Benvie, A.M., Blum, J.E., Kolba, N.J., Cosgrove, B.D., Thalacker-Mercer, A., Berry, D.C. Suppressing PDGFRβ Signaling Enhances Myocyte Fusion to Promote Skeletal Muscle Regeneration. (2024) bioRxiv. DOI: 10.1101/2024.10.15.618247
Blum, J.E., Kong, R., Schulman, E.A., Chen, F.M., Upadhyay, R., Romero-Meza, G., Littman, D.R., Fischbach, M.A., Nagashima, K., Sattely, E.S. Discovery and characterization of dietary antigens in oral tolerance. (2024) bioRxiv. DOI: 10.1101/2024.05.26.593976
Nagashima, K., Zhao, A., Atabakhsh, K., Bae, M., Blum, J.E., Weakley, A., Jain, S., Meng, X., Cheng, A.G., Wang, M., Higginbottom, S., Dimas, A., Murugkar, P., Sattely, E.S., Moon, J.J., Balskus, E.P., Fischbach, M.A. Mapping the T cell repertoire to a complex gut bacterial community. (2023) Nature. 621(7977):162-170. DOI: 10.1038/s41586-023-06431-8
Fiddler, J.L., Blum, J.E., Heyden, K.E., Castillo, L.F., Thalacker-Mercer, A.E., Field, M.S. Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activity. (2023) Genes & Nutrition. 18(1):5. DOI: 10.1186/s12263-023-00724-3
Blum, J.E., Gheller, B.J., Benvie, A., Field, M.S., Panizza, E., Vacanti, N.M., Berry, D., Thalacker-Mercer, A. Pyruvate Kinase M2 Supports Muscle Progenitor Cell Proliferation but Is Dispensable for Skeletal Muscle Regeneration after Injury. (2021) J Nutr. 151(11):3313-3328. DOI: 10.1093/jn/nxab251
Fiddler, J.L., Xiu, Y., Blum, J.E., Lamarre, S.G., Phinney, W.N., Stabler, S.P., Brosnan, M.E., Brosnan, J.T., Thalacker-Mercer, A.E., Field, M.S. Reduced Shmt2 Expression Impairs Mitochondrial Folate Accumulation and Respiration, and Leads to Uracil Accumulation in Mouse Mitochondrial DNA. (2021) J Nutr. 151(10):2882-2893. DOI: 10.1093/jn/nxab211
Thalacker-Mercer, A., Blum, J. Discovery and application of dietary compounds to optimize human health, a focus on skeletal muscle regeneration. (2021) Curr Opin Biotechnol. 70:131-135. DOI: 10.1016/j.copbio.2021.04.003
Blum, J., Epstein, R., Watts, S., Thalacker-Mercer, A. Importance of Nutrient Availability and Metabolism for Skeletal Muscle Regeneration. (2021) Frontiers in Physiology. 12:696018. DOI: 10.3389/fphys.2021.696018
Chen, H., Blum, J.E., Thalacker-Mercer, A., Gu, Z. Impact of the Whole Genome Duplication Event on PYK Activity and Effects of a PYK1 Mutation on Metabolism in . (2021) Front Mol Biosci. 8:656461. DOI: 10.3389/fmolb.2021.656461
Nichenko, A.S., Sorensen, J.R., Southern, W.M., Qualls, A.E., Schifino, A.G., McFaline-Figueroa, J., Blum, J.E., Tehrani, K.F., Yin, H., Mortensen, L.J., Thalacker-Mercer, A.E., Greising, S.M., Call, J.A. Lifelong Ulk1-Mediated Autophagy Deficiency in Muscle Induces Mitochondrial Dysfunction and Contractile Weakness. (2021) Int J Mol Sci. 22(4). DOI: 10.3390/ijms22041937
Gheller, B.J., Blum, J.E., Lim, E.W., Handzlik, M.K., Hannah Fong, E.H., Ko, A.C., Khanna, S., Gheller, M.E., Bender, E.L., Alexander, M.S., Stover, P.J., Field, M.S., Cosgrove, B.D., Metallo, C.M., Thalacker-Mercer, A.E. Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function. (2021) Molecular Metabolism. 43:101106. DOI: 10.1016/j.molmet.2020.101106
Gheller, B.J., Blum, J.E., Fong, E.H.H., Malysheva, O.V., Cosgrove, B.D., Thalacker-Mercer, A.E. A defined N6-methyladenosine (mA) profile conferred by METTL3 regulates muscle stem cell/myoblast state transitions. (2020) Cell Death Discov. 6(1):95. DOI: 10.1038/s41420-020-00328-5
Ntemiri, A., Ghosh, T.S., Gheller, M.E., Tran, T.T.T., Blum, J.E., Pellanda, P., Vlckova, K., Neto, M.C., Howell, A., Thalacker-Mercer, A., O'Toole, P.W. Whole Blueberry and Isolated Polyphenol-Rich Fractions Modulate Specific Gut Microbes in an In Vitro Colon Model and in a Pilot Study in Human Consumers. (2020) Nutrients. 12(9). DOI: 10.3390/nu12092800
Blum, J.E., Gheller, B.J., Hwang, S., Bender, E., Gheller, M., Thalacker-Mercer, A.E. Consumption of a Blueberry-Enriched Diet by Women for 6 Weeks Alters Determinants of Human Muscle Progenitor Cell Function. (2020) J Nutr. 150(9):2412-2418. DOI: 10.1093/jn/nxaa190
Gheller, B.J., Blum, J., Soueid-Baumgarten, S., Bender, E., Cosgrove, B.D., Thalacker-Mercer, A. Isolation, Culture, Characterization, and Differentiation of Human Muscle Progenitor Cells from the Skeletal Muscle Biopsy Procedure. (2019) JoVE.(150) DOI: 10.3791/59580
Gheller, B.J., Blum, J.E., Merritt, E.K., Cummings, B.P., Thalacker-Mercer, A.E. Peptide YY (PYY) Is Expressed in Human Skeletal Muscle Tissue and Expanding Human Muscle Progenitor Cells. (2019) Frontiers in Physiology. 10:188. DOI: 10.3389/fphys.2019.00188
BS, Human Biology, Cornell University, Ithaca, NY
PhD, Molecular Nutrition, Cornell University, Ithaca, NY
Postdoctoral Fellow, Chemical Engineering, Stanford University, Palo Alto, CA