Jamie Blum, PhD

NOMIS Assistant Professor

NOMIS Center for Immunobiology and Microbial Pathogenesis

Salk Institute for Biological Studies - Publications

all Publications


Qu, Y., Edwards, K., Li, M., Williams, M., Liu, Y., Tsai, P.Y., Cheng, C., Blum, J.E., Acor, N., Oshoe, T., Walter, C., Thirumalaikumar, V., Thalacker-Mercer, A.E., Skirycz, A., Barrow, J. Small Molecule Oxybutynin Rescues Proliferative Capacity of Complex III-Defective Muscle Progenitor Cells. (2025) Am J Physiol Cell Physiol. DOI: 10.1152/ajpcell.00141.2025

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Xue, S., Benvie, A.M., Blum, J.E., Kolba, N.J., Cosgrove, B.D., Thalacker-Mercer, A., Berry, D.C. Suppressing PDGFRβ Signaling Enhances Myocyte Fusion to Promote Skeletal Muscle Regeneration. (2024) bioRxiv. DOI: 10.1101/2024.10.15.618247

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Blum, J.E., Kong, R., Schulman, E.A., Chen, F.M., Upadhyay, R., Romero-Meza, G., Littman, D.R., Fischbach, M.A., Nagashima, K., Sattely, E.S. Discovery and characterization of dietary antigens in oral tolerance. (2024) bioRxiv. DOI: 10.1101/2024.05.26.593976

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Nagashima, K., Zhao, A., Atabakhsh, K., Bae, M., Blum, J.E., Weakley, A., Jain, S., Meng, X., Cheng, A.G., Wang, M., Higginbottom, S., Dimas, A., Murugkar, P., Sattely, E.S., Moon, J.J., Balskus, E.P., Fischbach, M.A. Mapping the T cell repertoire to a complex gut bacterial community. (2023) Nature. 621(7977):162-170. DOI: 10.1038/s41586-023-06431-8

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Fiddler, J.L., Blum, J.E., Heyden, K.E., Castillo, L.F., Thalacker-Mercer, A.E., Field, M.S. Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activity. (2023) Genes & Nutrition. 18(1):5. DOI: 10.1186/s12263-023-00724-3

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Blum, J.E., Gheller, B.J., Benvie, A., Field, M.S., Panizza, E., Vacanti, N.M., Berry, D., Thalacker-Mercer, A. Pyruvate Kinase M2 Supports Muscle Progenitor Cell Proliferation but Is Dispensable for Skeletal Muscle Regeneration after Injury. (2021) J Nutr. 151(11):3313-3328. DOI: 10.1093/jn/nxab251

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Fiddler, J.L., Xiu, Y., Blum, J.E., Lamarre, S.G., Phinney, W.N., Stabler, S.P., Brosnan, M.E., Brosnan, J.T., Thalacker-Mercer, A.E., Field, M.S. Reduced Shmt2 Expression Impairs Mitochondrial Folate Accumulation and Respiration, and Leads to Uracil Accumulation in Mouse Mitochondrial DNA. (2021) J Nutr. 151(10):2882-2893. DOI: 10.1093/jn/nxab211

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Thalacker-Mercer, A., Blum, J. Discovery and application of dietary compounds to optimize human health, a focus on skeletal muscle regeneration. (2021) Curr Opin Biotechnol. 70:131-135. DOI: 10.1016/j.copbio.2021.04.003

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Blum, J., Epstein, R., Watts, S., Thalacker-Mercer, A. Importance of Nutrient Availability and Metabolism for Skeletal Muscle Regeneration. (2021) Frontiers in Physiology. 12:696018. DOI: 10.3389/fphys.2021.696018

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Chen, H., Blum, J.E., Thalacker-Mercer, A., Gu, Z. Impact of the Whole Genome Duplication Event on PYK Activity and Effects of a PYK1 Mutation on Metabolism in . (2021) Front Mol Biosci. 8:656461. DOI: 10.3389/fmolb.2021.656461

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Nichenko, A.S., Sorensen, J.R., Southern, W.M., Qualls, A.E., Schifino, A.G., McFaline-Figueroa, J., Blum, J.E., Tehrani, K.F., Yin, H., Mortensen, L.J., Thalacker-Mercer, A.E., Greising, S.M., Call, J.A. Lifelong Ulk1-Mediated Autophagy Deficiency in Muscle Induces Mitochondrial Dysfunction and Contractile Weakness. (2021) Int J Mol Sci. 22(4). DOI: 10.3390/ijms22041937

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Gheller, B.J., Blum, J.E., Lim, E.W., Handzlik, M.K., Hannah Fong, E.H., Ko, A.C., Khanna, S., Gheller, M.E., Bender, E.L., Alexander, M.S., Stover, P.J., Field, M.S., Cosgrove, B.D., Metallo, C.M., Thalacker-Mercer, A.E. Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function. (2021) Molecular Metabolism. 43:101106. DOI: 10.1016/j.molmet.2020.101106

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Gheller, B.J., Blum, J.E., Fong, E.H.H., Malysheva, O.V., Cosgrove, B.D., Thalacker-Mercer, A.E. A defined N6-methyladenosine (mA) profile conferred by METTL3 regulates muscle stem cell/myoblast state transitions. (2020) Cell Death Discov. 6(1):95. DOI: 10.1038/s41420-020-00328-5

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Ntemiri, A., Ghosh, T.S., Gheller, M.E., Tran, T.T.T., Blum, J.E., Pellanda, P., Vlckova, K., Neto, M.C., Howell, A., Thalacker-Mercer, A., O'Toole, P.W. Whole Blueberry and Isolated Polyphenol-Rich Fractions Modulate Specific Gut Microbes in an In Vitro Colon Model and in a Pilot Study in Human Consumers. (2020) Nutrients. 12(9). DOI: 10.3390/nu12092800

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Blum, J.E., Gheller, B.J., Hwang, S., Bender, E., Gheller, M., Thalacker-Mercer, A.E. Consumption of a Blueberry-Enriched Diet by Women for 6 Weeks Alters Determinants of Human Muscle Progenitor Cell Function. (2020) J Nutr. 150(9):2412-2418. DOI: 10.1093/jn/nxaa190

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Gheller, B.J., Blum, J., Soueid-Baumgarten, S., Bender, E., Cosgrove, B.D., Thalacker-Mercer, A. Isolation, Culture, Characterization, and Differentiation of Human Muscle Progenitor Cells from the Skeletal Muscle Biopsy Procedure. (2019) JoVE.(150) DOI: 10.3791/59580

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Gheller, B.J., Blum, J.E., Merritt, E.K., Cummings, B.P., Thalacker-Mercer, A.E. Peptide YY (PYY) Is Expressed in Human Skeletal Muscle Tissue and Expanding Human Muscle Progenitor Cells. (2019) Frontiers in Physiology. 10:188. DOI: 10.3389/fphys.2019.00188

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Education

BS, Human Biology, Cornell University, Ithaca, NY
PhD, Molecular Nutrition, Cornell University, Ithaca, NY
Postdoctoral Fellow, Chemical Engineering, Stanford University, Palo Alto, CA


Awards & Honors

  • Life Sciences Research Foundation Fellowship, 2022
  • American Society for Nutrition Trainee Travel Award, 2018
  • National Science Foundation Graduate Research Fellowship, 2017