Greg Lemke

Professor

Molecular Neurobiology Laboratory

Françoise Gilot-Salk Chair

Greg Lemke
Salk Institute for Biological Studies - Publications

all Publications


McShane, L., Tabas, I., Lemke, G., Kurowska-Stolarska, M., Maffia, P. TAM Receptors in Cardiovascular Disease. (2019) Cardiovasc. Res. DOI: 10.1093/cvr/cvz100

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Lemke, G. How macrophages deal with death. (2019) Nature Reviews. Immunology. DOI: 10.1038/s41577-019-0167-y

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Lemke, G. Phosphatidylserine Is the Signal for TAM Receptors and Their Ligands. (2017) Trends in Biochemical Sciences. DOI: 10.1016/j.tibs.2017.06.004

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Kurowska-Stolarska, M., Alivernini, S., Melchor, E.G., Elmesmari, A., Tolusso, B., Tange, C., Petricca, L., Gilchrist, D.S., Di Sante, G., Keijzer, C., Stewart, L., Di Mario, C., Morrison, V., Brewer, J.M., Porter, D., Milling, S., Baxter, R.D., McCarey, D., Gremese, E., Lemke, G., Ferraccioli, G., McSharry, C., McInnes, I.B. MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis. (2017) Nature Communications. 8:15877. DOI: 10.1038/ncomms15877

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Savier, E., Eglen, S.J., Bathélémy, A., Perraut, M., Pfrieger, F.W., Lemke, G., Reber, M. A molecular mechanism for the topographic alignment of convergent neural maps. (2017) Elife. 6. DOI: 10.7554/eLife.20470

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Tufail, Y., Cook, D., Fourgeaud, L., Powers, C.J., Merten, K., Clark, C.L., Hoffman, E., Ngo, A., Sekiguchi, K.J., O'Shea, C.C., Lemke, G., Nimmerjahn, A. Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia. (2017) Neuron. 93(3):574-586.e8. DOI: 10.1016/j.neuron.2016.12.021

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Fourgeaud, L., Través, P.G., Tufail, Y., Leal-Bailey, H., Lew, E.D., Burrola, P.G., Callaway, P., Zagórska, A., Rothlin, C.V., Nimmerjahn, A., Lemke, G. TAM receptors regulate multiple features of microglial physiology. (2016) Nature. 532(7598):240-244. DOI: 10.1038/nature17630

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Lemke, G. Adopting ALK and LTK. (2015) Proceedings of the National Academy of Sciences of the United States of America. 112(52):15783-4. DOI: 10.1073/pnas.1521923113


Miner, J.J., Daniels, B.P., Shrestha, B., Proenca-Modena, J.L., Lew, E.D., Lazear, H.M., Gorman, M.J., Lemke, G., Klein, R.S., Diamond, M.S. The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity. (2015) Nature Medicine. 21(12):1464-72. DOI: 10.1038/nm.3974

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Fuhs, S.R., Meisenhelder, J., Aslanian, A., Ma, L., Zagorska, A., Stankova, M., Binnie, A., Al-Obeidi, F., Mauger, J., Lemke, G., Yates, J.R., Hunter, T. Monoclonal 1- and 3-Phosphohistidine Antibodies: New Tools to Study Histidine Phosphorylation. (2015) Cell. 162(1):198-210. DOI: 10.1016/j.cell.2015.05.046

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Dransfield, I., Zagórska, A., Lew, E.D., Michail, K., Lemke, G. Mer receptor tyrosine kinase mediates both tethering and phagocytosis of apoptotic cells. (2015) Cell Death & Disease. 6:e1646. DOI: 10.1038/cddis.2015.18

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Lemke, G., Lew, E.D. A ligand for ALK. (2015) Science Signaling. 8(360):fs2. DOI: 10.1126/scisignal.aaa5566

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Lemke, G., Julius, D. Stephen F. Heinemann: A true original. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(40):14314-5. DOI: 10.1073/pnas.1416208111


Zagórska, A., Través, P.G., Lew, E.D., Dransfield, I., Lemke, G. Diversification of TAM receptor tyrosine kinase function. (2014) Nature Immunology. 15(10):920-8. DOI: 10.1038/ni.2986

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Lew, E.D., Oh, J., Burrola, P.G., Lax, I., Zagórska, A., Través, P.G., Schlessinger, J., Lemke, G. Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities. (2014) Elife. 3. DOI: 10.7554/eLife.03385

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Lemke, G. Biology of the TAM receptors. (2013) Cold Spring Harbor Perspectives in Biology. 5(11):a009076. DOI: 10.1101/cshperspect.a009076

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Bhattacharyya, S., Zagórska, A., Lew, E.D., Shrestha, B., Rothlin, C.V., Naughton, J., Diamond, M.S., Lemke, G., Young, J.A. Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors. (2013) Cell Host & Microbe. 14(2):136-47. DOI: 10.1016/j.chom.2013.07.005

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Carrera Silva, E.A., Chan, P.Y., Joannas, L., Errasti, A.E., Gagliani, N., Bosurgi, L., Jabbour, M., Perry, A., Smith-Chakmakova, F., Mucida, D., Cheroutre, H., Burstyn-Cohen, T., Leighton, J.A., Lemke, G., Ghosh, S., Rothlin, C.V. T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response. (2013) Immunity. 39(1):160-70. DOI: 10.1016/j.immuni.2013.06.010

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Sullivan, B.M., Welch, M.J., Lemke, G., Oldstone, M.B. Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus? (2013) Journal of Virology. 87(7):4071-4. DOI: 10.1128/JVI.03268-12

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Burstyn-Cohen, T., Lew, E.D., Través, P.G., Burrola, P.G., Hash, J.C., Lemke, G. Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis. (2012) Neuron. 76(6):1123-32. DOI: 10.1016/j.neuron.2012.10.015

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Meertens, L., Carnec, X., Lecoin, M.P., Ramdasi, R., Guivel-Benhassine, F., Lew, E., Lemke, G., Schwartz, O., Amara, A. The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry. (2012) Cell Host & Microbe. 12(4):544-57. DOI: 10.1016/j.chom.2012.08.009

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Bauer, T., Zagórska, A., Jurkin, J., Yasmin, N., Köffel, R., Richter, S., Gesslbauer, B., Lemke, G., Strobl, H. Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis. (2012) Journal of Experimental Medicine. 209(11):2033-47. DOI: 10.1084/jem.20120493

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Slavotinek, A.M., Chao, R., Vacik, T., Yahyavi, M., Abouzeid, H., Bardakjian, T., Schneider, A., Shaw, G., Sherr, E.H., Lemke, G., Youssef, M., Schorderet, D.F. VAX1 mutation associated with microphthalmia, corpus callosum agenesis, and orofacial clefting: the first description of a VAX1 phenotype in humans. (2012) Human Mutation. 33(2):364-8. DOI: 10.1002/humu.21658

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Vacik, T., Lemke, G. Dominant-negative isoforms of Tcf/Lef proteins in development and disease. (2011) Cell Cycle. 10(24):4199-200. DOI: 10.4161/cc.10.24.18465


Wang, J., Zhang, H., Young, A.G., Qiu, R., Argalian, S., Li, X., Wu, X., Lemke, G., Lu, Q. Transcriptome analysis of neural progenitor cells by a genetic dual reporter strategy. (2011) Stem Cells. 29(10):1589-600. DOI: 10.1002/stem.699

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Vacik, T., Stubbs, J.L., Lemke, G. A novel mechanism for the transcriptional regulation of Wnt signaling in development. (2011) Genes & Development. 25(17):1783-95. DOI: 10.1101/gad.17227011

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Bevins, N., Lemke, G., Reber, M. Genetic dissection of EphA receptor signaling dynamics during retinotopic mapping. (2011) Journal of Neuroscience. 31(28):10302-10. DOI: 10.1523/JNEUROSCI.1652-11.2011

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Rothlin, C.V., Lemke, G. TAM receptor signaling and autoimmune disease. (2010) Current Opinion in Immunology. 22(6):740-6. DOI: 10.1016/j.coi.2010.10.001

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Lemke, G., Burstyn-Cohen, T. TAM receptors and the clearance of apoptotic cells. (2010) Ann. N. Y. Acad. Sci. 1209:23-9. DOI: 10.1111/j.1749-6632.2010.05744.x

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Burstyn-Cohen, T., Heeb, M.J., Lemke, G. Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. (2009) Journal of Clinical Investigation. 119(10):2942-53. DOI: 10.1172/JCI39325

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Triplett, J.W., Owens, M.T., Yamada, J., Lemke, G., Cang, J., Stryker, M.P., Feldheim, D.A. Retinal input instructs alignment of visual topographic maps. (2009) Cell. 139(1):175-85. DOI: 10.1016/j.cell.2009.08.028

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Stanojcic, M., Burstyn-Cohen, T., Nashi, N., Lemke, G., Sakic, B. Disturbed distribution of proliferative brain cells during lupus-like disease. (2009) Brain, Behavior, and Immunity. 23(7):1003-13. DOI: 10.1016/j.bbi.2009.05.061

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Kang, K.H., Lemke, G., Kim, J.W. The PI3K-PTEN tug-of-war, oxidative stress and retinal degeneration. (2009) Trends in Molecular Medicine. 15(5):191-8. DOI: 10.1016/j.molmed.2009.03.005

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Lemke, G. Isolation and analysis of the gene encoding peripheral myelin protein zero. (2008) Neuron. 60(3):403. DOI: 10.1016/j.neuron.2008.10.034


Kim, J.W., Kang, K.H., Burrola, P., Mak, T.W., Lemke, G. Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium. (2008) Genes & Development. 22(22):3147-57. DOI: 10.1101/gad.1700108

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Pierce, A., Bliesner, B., Xu, M., Nielsen-Preiss, S., Lemke, G., Tobet, S., Wierman, M.E. Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration. (2008) Molecular Endocrinology. 22(11):2481-95. DOI: 10.1210/me.2008-0169

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Lemke, G., Rothlin, C.V. Immunobiology of the TAM receptors. (2008) Nature Reviews. Immunology. 8(5):327-36. DOI: 10.1038/nri2303

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Gallarda, B.W., Bonanomi, D., Müller, D., Brown, A., Alaynick, W.A., Andrews, S.E., Lemke, G., Pfaff, S.L., Marquardt, T. Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling. (2008) Science. 320(5873):233-6. DOI: 10.1126/science.1153758

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Angelillo-Scherrer, A., Burnier, L., Lambrechts, D., Fish, R.J., Tjwa, M., Plaisance, S., Sugamele, R., DeMol, M., Martinez-Soria, E., Maxwell, P.H., Lemke, G., Goff, S.P., Matsushima, G.K., Earp, H.S., Chanson, M., Collen, D., Izui, S., Schapira, M., Conway, E.M., Carmeliet, P. Role of Gas6 in erythropoiesis and anemia in mice. (2008) Journal of Clinical Investigation. 118(2):583-96. DOI: 10.1172/JCI30375

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Rothlin, C.V., Ghosh, S., Zuniga, E.I., Oldstone, M.B., Lemke, G. TAM receptors are pleiotropic inhibitors of the innate immune response. (2007) Cell. 131(6):1124-36. DOI: 10.1016/j.cell.2007.10.034

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Roth, C., Rothlin, C., Riou, S., Raulet, D.H., Lemke, G. Stromal-cell regulation of natural killer cell differentiation. (2007) Journal of Molecular Medicine . 85(10):1047-56. DOI: 10.1007/s00109-007-0195-0

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de Preux, A.S., Goosen, K., Zhang, W., Sima, A.A., Shimano, H., Ouwens, D.M., Diamant, M., Hillebrands, J.L., Rozing, J., Lemke, G., Beckmann, J.S., Smit, A.B., Verheijen, M.H., Chrast, R. SREBP-1c expression in Schwann cells is affected by diabetes and nutritional status. (2007) Molecular and Cellular Neurosciences. 35(4):525-34. DOI: 10.1016/j.mcn.2007.04.010

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Seitz, H.M., Camenisch, T.D., Lemke, G., Earp, H.S., Matsushima, G.K. Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells. (2007) Journal of immunology. 178(9):5635-42.

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Reber, M., Hindges, R., Lemke, G. Eph receptors and ephrin ligands in axon guidance. (2007) Adv. Exp. Med. Biol. 621:32-49. DOI: 10.1007/978-0-387-76715-4_3


Stephen, L.J., Fawkes, A.L., Verhoeve, A., Lemke, G., Brown, A. A critical role for the EphA3 receptor tyrosine kinase in heart development. (2007) Developmental Biology. 302(1):66-79. DOI: 10.1016/j.ydbio.2006.08.058

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Kim, J.W., Lemke, G. Hedgehog-regulated localization of Vax2 controls eye development. (2006) Genes & Development. 20(20):2833-47. DOI: 10.1101/gad.1462706

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Prasad, D., Rothlin, C.V., Burrola, P., Burstyn-Cohen, T., Lu, Q., Garcia de Frutos, P., Lemke, G. TAM receptor function in the retinal pigment epithelium. (2006) Molecular and Cellular Neurosciences. 33(1):96-108. DOI: 10.1016/j.mcn.2006.06.011

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Sharif, M.N., Sosic, D., Rothlin, C.V., Kelly, E., Lemke, G., Olson, E.N., Ivashkiv, L.B. Twist mediates suppression of inflammation by type I IFNs and Axl. (2006) Journal of Experimental Medicine. 203(8):1891-901. DOI: 10.1084/jem.20051725

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Caraux, A., Lu, Q., Fernandez, N., Riou, S., Di Santo, J.P., Raulet, D.H., Lemke, G., Roth, C. Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases. (2006) Nature Immunology. 7(7):747-54. DOI: 10.1038/ni1353

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Shankar, S.L., O'Guin, K., Kim, M., Varnum, B., Lemke, G., Brosnan, C.F., Shafit-Zagardo, B. Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis. (2006) Journal of Neuroscience. 26(21):5638-48. DOI: 10.1523/JNEUROSCI.5063-05.2006

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Lemke, G. Neuregulin-1 and myelination. (2006) Sci. STKE. 2006(325):pe11. DOI: 10.1126/stke.3252006pe11

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Radic, M.Z., Shah, K., Zhang, W., Lu, Q., Lemke, G., Hilliard, G.M. Heterogeneous nuclear ribonucleoprotein P2 is an autoantibody target in mice deficient for Mer, Axl, and Tyro3 receptor tyrosine kinases. (2006) Journal of immunology. 176(1):68-74.

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Budagian, V., Bulanova, E., Orinska, Z., Duitman, E., Brandt, K., Ludwig, A., Hartmann, D., Lemke, G., Saftig, P., Bulfone-Paus, S. Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum. (2005) Molecular and Cellular Biology. 25(21):9324-39. DOI: 10.1128/MCB.25.21.9324-9339.2005

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Lemke, G., Reber, M. Retinotectal mapping: new insights from molecular genetics. (2005) Annual Review of Cell and Developmental Biology. 21:551-80. DOI: 10.1146/annurev.cellbio.20.022403.093702

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Mui, S.H., Kim, J.W., Lemke, G., Bertuzzi, S. Vax genes ventralize the embryonic eye. (2005) Genes & Development. 19(10):1249-59. DOI: 10.1101/gad.1276605

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Angelillo-Scherrer, A., Burnier, L., Flores, N., Savi, P., DeMol, M., Schaeffer, P., Herbert, J.M., Lemke, G., Goff, S.P., Matsushima, G.K., Earp, H.S., Vesin, C., Hoylaerts, M.F., Plaisance, S., Collen, D., Conway, E.M., Wehrle-Haller, B., Carmeliet, P. Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. (2005) Journal of Clinical Investigation. 115(2):237-46. DOI: 10.1172/JCI22079

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Reber, M., Burrola, P., Lemke, G. A relative signalling model for the formation of a topographic neural map. (2004) Nature. 431(7010):847-53. DOI: 10.1038/nature02957

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Chrast, R., Verheijen, M.H., Lemke, G. Complement factors in adult peripheral nerve: a potential role in energy metabolism. (2004) Neurochem. Int. 45(2-3):353-9. DOI: 10.1016/j.neuint.2003.09.011

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Vaidya, A., Pniak, A., Lemke, G., Brown, A. EphA3 null mutants do not demonstrate motor axon guidance defects. (2003) Molecular and Cellular Biology. 23(22):8092-8.

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Senderek, J., Bergmann, C., Stendel, C., Kirfel, J., Verpoorten, N., De Jonghe, P., Timmerman, V., Chrast, R., Verheijen, M.H., Lemke, G., Battaloglu, E., Parman, Y., Erdem, S., Tan, E., Topaloglu, H., Hahn, A., Müller-Felber, W., Rizzuto, N., Fabrizi, G.M., Stuhrmann, M., Rudnik-Schöneborn, S., Züchner, S., Michael Schröder, J., Buchheim, E., Straub, V., Klepper, J., Huehne, K., Rautenstrauss, B., Büttner, R., Nelis, E., Zerres, K. Mutations in a gene encoding a novel SH3/TPR domain protein cause autosomal recessive Charcot-Marie-Tooth type 4C neuropathy. (2003) American Journal of Human Genetics. 73(5):1106-19. DOI: 10.1086/379525

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Verheijen, M.H., Chrast, R., Burrola, P., Lemke, G. Local regulation of fat metabolism in peripheral nerves. (2003) Genes & Development. 17(19):2450-64. DOI: 10.1101/gad.1116203

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Zhu, D., Kennerson, M., Merory, J., Chrast, R., Verheijen, M., Lemke, G., Nicholson, G. Refined localization of dominant intermediate Charcot-Marie-Tooth neuropathy and exclusion of seven known candidate genes in the region. (2003) Neurogenetics. 4(4):179-83. DOI: 10.1007/s10048-003-0147-y

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Lemke, G., Lu, Q. Macrophage regulation by Tyro 3 family receptors. (2003) Current Opinion in Immunology. 15(1):31-6.


Stefansson, H., Sigurdsson, E., Steinthorsdottir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Gunnarsdottir, S., Ivarsson, O., Chou, T.T., Hjaltason, O., Birgisdottir, B., Jonsson, H., Gudnadottir, V.G., Gudmundsdottir, E., Bjornsson, A., Ingvarsson, B., Ingason, A., Sigfusson, S., Hardardottir, H., Harvey, R.P., Lai, D., Zhou, M., Brunner, D., Mutel, V., Gonzalo, A., Lemke, G., Sainz, J., Johannesson, G., Andresson, T., Gudbjartsson, D., Manolescu, A., Frigge, M.L., Gurney, M.E., Kong, A., Gulcher, J.R., Petursson, H., Stefansson, K. Neuregulin 1 and susceptibility to schizophrenia. (2002) American Journal of Human Genetics. 71(4):877-92. DOI: 10.1086/342734

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Mui, S.H., Hindges, R., O'Leary, D.D., Lemke, G., Bertuzzi, S. The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye. (2002) Development. 129(3):797-804.

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Lu, Q., Lemke, G. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. (2001) Science. 293(5528):306-11. DOI: 10.1126/science.1061663

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Lemke, G. Glial control of neuronal development. (2001) Annual Review of Neuroscience. 24:87-105. DOI: 10.1146/annurev.neuro.24.1.87

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Syroid, D.E., Maycox, P.J., Soilu-Hänninen, M., Petratos, S., Bucci, T., Burrola, P., Murray, S., Cheema, S., Lee, K.F., Lemke, G., Kilpatrick, T.J. Induction of postnatal schwann cell death by the low-affinity neurotrophin receptor in vitro and after axotomy. (2000) Journal of Neuroscience. 20(15):5741-7.

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Brown, A., Yates, P.A., Burrola, P., Ortuño, D., Vaidya, A., Jessell, T.M., Pfaff, S.L., O'Leary, D.D., Lemke, G. Topographic mapping from the retina to the midbrain is controlled by relative but not absolute levels of EphA receptor signaling. (2000) Cell. 102(1):77-88.

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Kilpatrick, T.J., Ortuño, D., Bucci, T., Lai, C., Lemke, G. Rat oligodendroglia express c-met and focal adhesion kinase, protein tyrosine kinases implicated in regulating epithelial cell motility. (2000) Neurosci. Lett. 279(1):5-8.

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Bertuzzi, S., Hindges, R., Mui, S.H., O'Leary, D.D., Lemke, G. The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain. (1999) Genes & Development. 13(23):3092-105.

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Lu, Q., Gore, M., Zhang, Q., Camenisch, T., Boast, S., Casagranda, F., Lai, C., Skinner, M.K., Klein, R., Matsushima, G.K., Earp, H.S., Goff, S.P., Lemke, G. Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. (1999) Nature. 398(6729):723-8. DOI: 10.1038/19554

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Krappa, R., Nguyen, A., Burrola, P., Deretic, D., Lemke, G. Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes. (1999) Proceedings of the National Academy of Sciences of the United States of America. 96(8):4633-8.

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Zorick, T.S., Syroid, D.E., Brown, A., Gridley, T., Lemke, G. Krox-20 controls SCIP expression, cell cycle exit and susceptibility to apoptosis in developing myelinating Schwann cells. (1999) Development. 126(7):1397-406.

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Syroid, D.E., Zorick, T.S., Arbet-Engels, C., Kilpatrick, T.J., Eckhart, W., Lemke, G. A role for insulin-like growth factor-I in the regulation of Schwann cell survival. (1999) Journal of Neuroscience. 19(6):2059-68.

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Lemke, G., Barde, Y.A. Neuronal and glial cell biology. (1998) Current Opinion in Neurobiology. 8(5):567-569.


Désarnaud, F., Do Thi, A.N., Brown, A.M., Lemke, G., Suter, U., Baulieu, E.E., Schumacher, M. Progesterone stimulates the activity of the promoters of peripheral myelin protein-22 and protein zero genes in Schwann cells. (1998) J. Neurochem. 71(4):1765-8.

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Zhao, J.J., Lemke, G. Selective disruption of neuregulin-1 function in vertebrate embryos using ribozyme-tRNA transgenes. (1998) Development. 125(10):1899-907.

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Zhao, J.J., Lemke, G. Rules for ribozymes. (1998) Molecular and Cellular Neurosciences. 11(1-2):92-7. DOI: 10.1006/mcne.1998.0669

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Lemke, G. Eph receptors and ligands in axon pathway choice, target recognition, and synaptogenesis. (1998) Progress in Brain Research. 117:171-6. DOI: https://doi.org/10.1016/S0079-6123(08)64015-7


Brown, A.M., Lemke, G. Multiple regulatory elements control transcription of the peripheral myelin protein zero gene. (1997) Journal of Biological Chemistry. 272(46):28939-47.

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Lemke, G. A coherent nomenclature for Eph receptors and their ligands. (1997) Molecular and Cellular Neurosciences. 9(5-6):331-2. DOI: 10.1006/mcne.1997.0630


Maycox, P.R., Ortuño, D., Burrola, P., Kuhn, R., Bieri, P.L., Arrezo, J.C., Lemke, G. A transgenic mouse model for human hereditary neuropathy with liability to pressure palsies. (1997) Molecular and Cellular Neurosciences. 8(6):405-16. DOI: 10.1006/mcne.1997.0600

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Gassmann, M., Lemke, G. Neuregulins and neuregulin receptors in neural development. (1997) Current Opinion in Neurobiology. 7(1):87-92.

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Zorick, T.S., Lemke, G. Schwann cell differentiation. (1996) Current Opinion in Cell Biology. 8(6):870-6.

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Syroid, D.E., Maycox, P.R., Burrola, P.G., Liu, N., Wen, D., Lee, K.F., Lemke, G., Kilpatrick, T.J. Cell death in the Schwann cell lineage and its regulation by neuregulin. (1996) Proceedings of the National Academy of Sciences of the United States of America. 93(17):9229-34.

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Zorick, T.S., Syroid, D.E., Arroyo, E., Scherer, S.S., Lemke, G. The Transcription Factors SCIP and Krox-20 Mark Distinct Stages and Cell Fates in Schwann Cell Differentiation (1996) Molecular and Cellular Neurosciences. 8(2/3):129-45. DOI: 10.1006/mcne.1996.0052

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Zorick, T.S., Syroid, D.E., Arroyo, E., Scherer, S.S., Lemke, G. The transcription factors SCIP and Krox-20 mark distinct stages and cell fates in Schwann cell differentiation. (1996) Molecular and Cellular Neurosciences. 8(2-3):129-45. DOI: 10.1006/mcne.1996.0052

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Lemke, G. Neuregulins in development. (1996) Molecular and Cellular Neurosciences. 7(4):247-62. DOI: 10.1006/mcne.1996.0019


Kilpatrick, T.J., Brown, A., Lai, C., Gassmann, M., Goulding, M., Lemke, G. Expression of the Tyro4/Mek4/Cek4 gene specifically marks a subset of embryonic motor neurons and their muscle targets. (1996) Molecular and Cellular Neurosciences. 7(1):62-74. DOI: 10.1006/mcne.1996.0005

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Gassmann, M., Casagranda, F., Orioli, D., Simon, H., Lai, C., Klein, R., Lemke, G. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. (1995) Nature. 378(6555):390-4. DOI: 10.1038/378390a0

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Weinstein, D.E., Burrola, P.G., Lemke, G. Premature Schwann cell differentiation and hypermyelination in mice expressing a targeted antagonist of the POU transcription factor SCIP. (1995) Molecular and Cellular Neurosciences. 6(3):212-29. DOI: 10.1006/mcne.1995.1018

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Plantinga, L.C., Schrama, L.H., Eggen, B.J., Gispen, W.H., Verhaagen, J., Lemke, G. B-50/GAP-43 mRNA expression in cultured primary Schwann cells is regulated by cyclic AMP. (1994) Neuroreport. 5(18):2465-8.

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Lai, C., Gore, M., Lemke, G. Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase. (1994) Oncogene. 9(9):2567-78.

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Messing, A., Behringer, R.R., Wrabetz, L., Hammang, J.P., Lemke, G., Palmiter, R.D., Brinster, R.L. Hypomyelinating peripheral neuropathies and schwannomas in transgenic mice expressing SV40 T-antigen. (1994) Journal of Neuroscience. 14(6):3533-9.

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Lai, C., Lemke, G. Structure and expression of the Tyro 10 receptor tyrosine kinase. (1994) Oncogene. 9(3):877-83.

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Monuki, E.S., Kuhn, R., Lemke, G. Cell-specific action and mutable structure of a transcription factor effector domain. (1993) Proceedings of the National Academy of Sciences of the United States of America. 90(21):9978-82.

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Lemke, G. Transcriptional regulation of the development of neurons and glia. (1993) Current Opinion in Neurobiology. 3(5):703-8.

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Monuki, E.S., Kuhn, R., Lemke, G. Repression of the myelin P0 gene by the POU transcription factor SCIP. (1993) Mech. Dev. 42(1-2):15-32.

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Lemke, G. The molecular genetics of myelination: an update. (1993) Glia. 7(4):263-71. DOI: 10.1002/glia.440070402

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Weinmaster, G., Roberts, V.J., Lemke, G. Notch2: a second mammalian Notch gene. (1992) Development. 116(4):931-41.

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Lemke, G., Kuhn, R., Monuki, E.S., Weinmaster, G. Expression and activity of the transcription factor SCIP during glial differentiation and myelination. (1991) Ann. N. Y. Acad. Sci. 633:189-95. DOI: https://doi.org/10.1111/j.1749-6632.1991.tb15609.x


Spreyer, P., Kuhn, G., Hanemann, C.O., Gillen, C., Schaal, H., Kuhn, R., Lemke, G., Müller, H.W. Axon-regulated expression of a Schwann cell transcript that is homologous to a 'growth arrest-specific' gene. (1991) EMBO Journal. 10(12):3661-8.

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Nave, K.A., Lemke, G. Induction of the myelin proteolipid protein (PLP) gene in C6 glioblastoma cells: functional analysis of the PLP promotor. (1991) Journal of Neuroscience. 11(10):3060-9.

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Weinmaster, G., Roberts, V.J., Lemke, G. A homolog of Drosophila Notch expressed during mammalian development. (1991) Development. 113(1):199-205.

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Kuhn, R., Monuki, E.S., Lemke, G. The gene encoding the transcription factor SCIP has features of an expressed retroposon. (1991) Molecular and Cellular Biology. 11(9):4642-50.

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Lai, C., Lemke, G. An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. (1991) Neuron. 6(5):691-704.

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Lemke, G., Kuhn, R., Monuki, E.S., Weinmaster, G. Transcriptional controls underlying Schwann cell differentiation and myelination. (1990) Ann. N. Y. Acad. Sci. 605:248-53. DOI: https://doi.org/10.1111/j.1749-6632.1990.tb42397.x


Monuki, E.S., Kuhn, R., Weinmaster, G., Trapp, B.D., Lemke, G. Expression and activity of the POU transcription factor SCIP. (1990) Science. 249(4974):1300-3.

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Messing, A., Behringer, R.R., Slapak, J.R., Lemke, G., Palmiter, R.D., Brinster, R.L. Insertional mutation at the ld locus (again!) in a line of transgenic mice. (1990) Mouse Genome. 87:107.


Weinmaster, G., Lemke, G. Cell-specific cyclic AMP-mediated induction of the PDGF receptor. (1990) EMBO Journal. 9(3):915-20.

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Kuhn, R., Pravtcheva, D., Ruddle, F., Lemke, G. The gene encoding peripheral myelin protein zero is located on mouse chromosome 1. (1990) Journal of Neuroscience. 10(1):205-9.

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Monuki, E.S., Weinmaster, G., Kuhn, R., Lemke, G. SCIP: a glial POU domain gene regulated by cyclic AMP. (1989) Neuron. 3(6):783-93.

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Lemke, G. Unwrapping the genes of myelin. (1988) Neuron. 1(7):535-43.


Lemke, G., Chao, M. Axons regulate Schwann cell expression of the major myelin and NGF receptor genes. (1988) Development. 102(3):499-504.

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Lemke, G., Lamar, E., Patterson, J. Isolation and analysis of the gene encoding peripheral myelin protein zero. (1988) Neuron. 1(1):73-83.

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Webster, H.F., Lamperth, L., Favilla, J.T., Lemke, G., Tesin, D., Manuelidis, L. Use of a biotinylated probe and in situ hybridization for light and electron microscopic localization of Po mRNA in myelin-forming Schwann cells. (1987) Histochemistry. 86(5):441-4.

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Lemke, G., Axel, R. Isolation and sequence of a cDNA encoding the major structural protein of peripheral myelin. (1985) Cell. 40(3):501-8.

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Lemke, G.E., Brockes, J.P. Identification and purification of glial growth factor. (1984) Journal of Neuroscience. 4(1):75-83.

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Lemke, G.E., Brockes, J.P. Glial growth factor: a mitogenic polypeptide of the brain and pituitary. (1983) Fed. Proc. 42(9):2627-9.

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Brockes, J.P., Fryxell, K.J., Lemke, G.E. Studies on cultured Schwann cells: the induction of myelin synthesis, and the control of their proliferation by a new growth factor. (1981) Journal of Experimental Biology. 95:215-30.

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Brockes, J.P., Lemke, G.E., Balzer, D.R. Purification and preliminary characterization of a glial growth factor from the bovine pituitary. (1980) Journal of Biological Chemistry. 255(18):8374-7.

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Education

BS, Life Sciences, Massachusetts Institute of Technology
PhD, Biology, California Institute of Technology
Postdoctoral Fellowship, Columbia University


Awards & Honors

  • 2008 AAAS Fellow
  • 1994 Javits Neuroscience Investigator Award
  • 1990 Rita Allen Scholars award
  • 1986 Pew Scholar Award
  • 1987 Basil O'Connor Starter Scholar Award, March of Dimes