Edward Stites

Assistant Professor

Integrative Biology Laboratory

Salk Institute for Biological Studies - Publications

all Publications


McFall, T., Diedrich, J.K., Mengistu, M., Littlechild, S.L., Paskvan, K.V., Sisk-Hackworth, L., Moresco, J.J., Shaw, A.S., Stites, E.C. A systems mechanism for KRAS mutant allele-specific responses to targeted therapy. (2019) Science Signaling. 12(600). DOI: 10.1126/scisignal.aaw8288

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Erickson, K.E., Rukhlenko, O.S., Shahinuzzaman, M., Slavkova, K.P., Lin, Y.T., Suderman, R., Stites, E.C., Anghel, M., Posner, R.G., Barua, D., Kholodenko, B.N., Hlavacek, W.S. Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor. (2019) PLOS Computational Biology. 15(1):e1006706. DOI: 10.1371/journal.pcbi.1006706

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Rauen, K.A., Schoyer, L., Schill, L., Stronach, B., Albeck, J., Andresen, B.S., Cavé, H., Ellis, M., Fruchtman, S.M., Gelb, B.D., Gibson, C.C., Gripp, K., Hefner, E., Huang, W.Y.C., Itkin, M., Kerr, B., Linardic, C.M., McMahon, M., Oberlander, B., Perlstein, E., Ratner, N., Rogers, L., Schenck, A., Shankar, S., Shvartsman, S., Stevenson, D.A., Stites, E.C., Stork, P.J.S., Sun, C., Therrien, M., Ullian, E.M., Widemann, B.C., Yeh, E., Zampino, G., Zenker, M., Timmer, W., McCormick, F. Proceedings of the fifth international RASopathies symposium: When development and cancer intersect. (2018) Am. J. Med. Genet. A.:e40632 DOI: 10.1002/ajmg.a.40632

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Stites, E.C., Shaw, A.S. Quantitative Systems Pharmacology Analysis of KRAS G12C Covalent Inhibitors. (2018) CPT Pharmacometrics Syst Pharmacol. 7(5):342-351. DOI: 10.1002/psp4.12291

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Ramanathan, R.K., Weiss, G.J., Posner, R.G., Rajeshkumar, N.V., Jameson, G., Aziz, M., Hoering, A., Bolejack, V., Maitra, A., Fulk, M., Stites, E.C., Hlavacek, W.S., Gatalica, Z., Xiu, J., Hidalgo, M., Von Hoff, D.D., Barrett, M.T. A phase 2 trial of personalized cytotoxic therapy based on tumor immunohistochemistry in previously treated metastatic pancreatic cancer patients. (2017) J Gastrointest Oncol. 8(6):925-935. DOI: 10.21037/jgo.2017.09.05

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Stites, E.C., Aziz, M., Creamer, M.S., Von Hoff, D.D., Posner, R.G., Hlavacek, W.S. Use of mechanistic models to integrate and analyze multiple proteomic datasets. (2015) Biophysical Journal. 108(7):1819-1829. DOI: 10.1016/j.bpj.2015.02.030

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Stites, E.C., Trampont, P.C., Haney, L.B., Walk, S.F., Ravichandran, K.S. Cooperation between Noncanonical Ras Network Mutations. (2015) Cell Reports. DOI: 10.1016/j.celrep.2014.12.035

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Hu, J., Stites, E.C., Yu, H., Germino, E.A., Meharena, H.S., Stork, P.J.S., Kornev, A.P., Taylor, S.S., Shaw, A.S. Allosteric activation of functionally asymmetric RAF kinase dimers. (2013) Cell. 154(5):1036-1046. DOI: 10.1016/j.cell.2013.07.046

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Stites, E.C. Chemical kinetic mechanistic models to investigate cancer biology and impact cancer medicine. (2013) Phys Biol. 10(2):026004. DOI: 10.1088/1478-3975/10/2/026004

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Liang, W.S., Craig, D.W., Carpten, J., Borad, M.J., Demeure, M.J., Weiss, G.J., Izatt, T., Sinari, S., Christoforides, A., Aldrich, J., Kurdoglu, A., Barrett, M., Phillips, L., Benson, H., Tembe, W., Braggio, E., Kiefer, J.A., Legendre, C., Posner, R., Hostetter, G.H., Baker, A., Egan, J.B., Han, H., Lake, D., Stites, E.C., Ramanathan, R.K., Fonseca, R., Stewart, A.K., Von Hoff, D. Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing. (2012) PLOS One. 7(10):e43192. DOI: 10.1371/journal.pone.0043192

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Stites, E.C. The response of cancers to BRAF inhibition underscores the importance of cancer systems biology. (2012) Science Signaling. 5(246):pe46. DOI: 10.1126/scisignal.2003354

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Creamer, M.S., Stites, E.C., Aziz, M., Cahill, J.A., Tan, C.W., Berens, M.E., Han, H., Bussey, K.J., Von Hoff, D.D., Hlavacek, W.S., Posner, R.G. Specification, annotation, visualization and simulation of a large rule-based model for ERBB receptor signaling. (2012) BMC Systems Biology. 6:107. DOI: 10.1186/1752-0509-6-107

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Stites, E.C., Ravichandran, K.S. Mechanistic modeling to investigate signaling by oncogenic Ras mutants. (2012) Wiley Interdisciplinary Reviews. Systems biology and Medicine. 4(1):117-27. DOI: 10.1002/wsbm.156

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Stites, E.C., Ravichandran, K.S. Mathematical investigation of how oncogenic ras mutants promote ras signaling. (2012) Methods in Molecular Biology. 880:69-85. DOI: 10.1007/978-1-61779-833-7_5

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Stites, E.C. Modeling membrane localization: case study of a Ras signaling model. (2010) Adv. Exp. Med. Biol. 680:661-7. DOI: 10.1007/978-1-4419-5913-3_73

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Stites, E.C., Ravichandran, K.S. A systems perspective of ras signaling in cancer. (2009) Clinical cancer research. 15(5):1510-3. DOI: 10.1158/1078-0432.CCR-08-2753

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Stites, E.C., Trampont, P.C., Ma, Z., Ravichandran, K.S. Network analysis of oncogenic Ras activation in cancer. (2007) Science. 318(5849):463-7. DOI: 10.1126/science.1144642

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Stites, E.C., Abbas, J.J. Sensitivity and versatility of an adaptive system for controlling cyclic movements using functional neuromuscular stimulation. (2000) IEEE Trans Biomed Eng. 47(9):1287-92. DOI: 10.1109/10.867965

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Education

BS, Mathematics, University of Kentucky
PhD, Biophysics, University of Virginia
MD, University of Virginia
Residency, Clinical Pathology, Washington University in St. Louis


Awards & Honors

  • 2017 NCI K22 Career Development Award
  • 2010 Randy Pausch Scholar
  • 2009 Michael J. Peach Award