Edward Stites

Assistant Professor

Integrative Biology Laboratory

Salk Institute for Biological Studies - Publications

all Publications


Stites, E.C., Shaw, A.S. Quantitative Systems Pharmacology Analysis of KRAS G12C Covalent Inhibitors. (2018) CPT Pharmacometrics Syst Pharmacol. 7(5):342-351. DOI: 10.1002/psp4.12291

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Ramanathan, R.K., Weiss, G.J., Posner, R.G., Rajeshkumar, N.V., Jameson, G., Aziz, M., Hoering, A., Bolejack, V., Maitra, A., Fulk, M., Stites, E.C., Hlavacek, W.S., Gatalica, Z., Xiu, J., Hidalgo, M., Von Hoff, D.D., Barrett, M.T. A phase 2 trial of personalized cytotoxic therapy based on tumor immunohistochemistry in previously treated metastatic pancreatic cancer patients. (2017) J Gastrointest Oncol. 8(6):925-935. DOI: 10.21037/jgo.2017.09.05

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Stites, E.C., Aziz, M., Creamer, M.S., Von Hoff, D.D., Posner, R.G., Hlavacek, W.S. Use of mechanistic models to integrate and analyze multiple proteomic datasets. (2015) Biophys. J. 108(7):1819-1829. DOI: 10.1016/j.bpj.2015.02.030

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Stites, E.C., Trampont, P.C., Haney, L.B., Walk, S.F., Ravichandran, K.S. Cooperation between Noncanonical Ras Network Mutations. (2015) Cell Rep. DOI: 10.1016/j.celrep.2014.12.035

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Hu, J., Stites, E.C., Yu, H., Germino, E.A., Meharena, H.S., Stork, P.J.S., Kornev, A.P., Taylor, S.S., Shaw, A.S. Allosteric activation of functionally asymmetric RAF kinase dimers. (2013) Cell. 154(5):1036-1046. DOI: 10.1016/j.cell.2013.07.046

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Stites, E.C. Chemical kinetic mechanistic models to investigate cancer biology and impact cancer medicine. (2013) Phys Biol. 10(2):026004. DOI: 10.1088/1478-3975/10/2/026004

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Liang, W.S., Craig, D.W., Carpten, J., Borad, M.J., Demeure, M.J., Weiss, G.J., Izatt, T., Sinari, S., Christoforides, A., Aldrich, J., Kurdoglu, A., Barrett, M., Phillips, L., Benson, H., Tembe, W., Braggio, E., Kiefer, J.A., Legendre, C., Posner, R., Hostetter, G.H., Baker, A., Egan, J.B., Han, H., Lake, D., Stites, E.C., Ramanathan, R.K., Fonseca, R., Stewart, A.K., Von Hoff, D. Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing. (2012) PLoS ONE. 7(10):e43192. DOI: 10.1371/journal.pone.0043192

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Stites, E.C. The response of cancers to BRAF inhibition underscores the importance of cancer systems biology. (2012) Sci Signal. 5(246):pe46. DOI: 10.1126/scisignal.2003354

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Creamer, M.S., Stites, E.C., Aziz, M., Cahill, J.A., Tan, C.W., Berens, M.E., Han, H., Bussey, K.J., Von Hoff, D.D., Hlavacek, W.S., Posner, R.G. Specification, annotation, visualization and simulation of a large rule-based model for ERBB receptor signaling. (2012) BMC Syst Biol. 6:107. DOI: 10.1186/1752-0509-6-107

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Stites, E.C., Ravichandran, K.S. Mechanistic modeling to investigate signaling by oncogenic Ras mutants. (2012) Wiley Interdiscip Rev Syst Biol Med. 4(1):117-27. DOI: 10.1002/wsbm.156

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Stites, E.C., Ravichandran, K.S. Mathematical investigation of how oncogenic ras mutants promote ras signaling. (2012) Methods Mol. Biol. 880:69-85. DOI: 10.1007/978-1-61779-833-7_5

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Stites, E.C. Modeling membrane localization: case study of a Ras signaling model. (2010) Adv. Exp. Med. Biol. 680:661-7. DOI: 10.1007/978-1-4419-5913-3_73

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Stites, E.C., Ravichandran, K.S. A systems perspective of ras signaling in cancer. (2009) Clin. Cancer Res. 15(5):1510-3. DOI: 10.1158/1078-0432.CCR-08-2753

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Stites, E.C., Trampont, P.C., Ma, Z., Ravichandran, K.S. Network analysis of oncogenic Ras activation in cancer. (2007) Science. 318(5849):463-7. DOI: 10.1126/science.1144642

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Stites, E.C., Abbas, J.J. Sensitivity and versatility of an adaptive system for controlling cyclic movements using functional neuromuscular stimulation. (2000) IEEE Trans Biomed Eng. 47(9):1287-92. DOI: 10.1109/10.867965

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Education

BS, Mathematics, University of Kentucky
PhD, Biophysics, University of Virginia
MD, University of Virginia
Residency, Clinical Pathology, Washington University in St. Louis


Awards & Honors

  • 2017 NCI K22 Career Development Award
  • 2010 Randy Pausch Scholar
  • 2009 Michael J. Peach Award

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