Dave Schubert

Professor and Laboratory Head

Cellular Neurobiology Laboratory

Salk Institute for Biological Studies - Schubert – Publications

all Publications


Currais, A., Huang, L., Goldberg, J., Petrascheck, M., Ates, G., Pinto-Duarte, A., Shokhirev, M.N., Schubert, D., Maher, P. Elevating acetyl-CoA levels reduces aspects of brain aging. (2019) Elife. 8. DOI: 10.7554/eLife.47866

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Schubert, D., Kepchia, D., Liang, Z., Dargusch, R., Goldberg, J., Maher, P. Efficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer's Disease. (2019) Molecular Neurobiology. 56(11):7719-7730. DOI: 10.1007/s12035-019-1637-8

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Lapchak, P.A., Boitano, P.D., Bombien, R., Cook, D.J., Doyan, S., Lara, J.M., Schubert, D.R. CNB-001, a pleiotropic drug is efficacious in embolized agyrencephalic New Zealand white rabbits and ischemic gyrencephalic cynomolgus monkeys. (2018) Experimental Neurology. DOI: 10.1016/j.expneurol.2018.11.010

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Carmona, V., Martín-Aragón, S., Goldberg, J., Schubert, D., Bermejo-Bescós, P. Several targets involved in Alzheimer's disease amyloidogenesis are affected by morin and isoquercitrin. (2018) Nutritional Neuroscience.:1-16 DOI: 10.1080/1028415X.2018.1534793

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Schubert, D., Currais, A., Goldberg, J., Finley, K., Petrascheck, M., Maher, P. Geroneuroprotectors: Effective Geroprotectors for the Brain. (2018) Trends in Pharmacological Sciences. 39(12):1004-1007. DOI: 10.1016/j.tips.2018.09.008

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Goldberg, J., Currais, A., Prior, M., Fischer, W., Chiruta, C., Ratliff, E., Daugherty, D., Dargusch, R., Finley, K., Esparza-Moltó, P.B., Cuezva, J.M., Maher, P., Petrascheck, M., Schubert, D. The mitochondrial ATP synthase is a shared drug target for aging and dementia. (2018) Aging Cell. 17(2). DOI: 10.1111/acel.12715

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Daugherty, D.J., Marquez, A., Calcutt, N.A., Schubert, D. A novel curcumin derivative for the treatment of diabetic neuropathy. (2017) Neuropharmacology. DOI: 10.1016/j.neuropharm.2017.11.007

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Daugherty, D., Goldberg, J., Fischer, W., Dargusch, R., Maher, P., Schubert, D. A novel Alzheimer's disease drug candidate targeting inflammation and fatty acid metabolism. (2017) Alzheimers Res Ther. 9(1):50. DOI: 10.1186/s13195-017-0277-3

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Currais, A., Farrokhi, C., Dargusch, R., Armando, A., Quehenberger, O., Schubert, D., Maher, P. Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse. (2017) J. Gerontol. A Biol. Sci. Med. Sci. 73(3):299-307. DOI: 10.1093/gerona/glx104

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Currais, A., Fischer, W., Maher, P., Schubert, D. Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain. (2017) FASEB Journal. 31(1):5-10. DOI: 10.1096/fj.201601184

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Currais, A., Quehenberger, O., M Armando, A., Daugherty, D., Maher, P., Schubert, D. Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. (2016) NPJ Aging and Mechanisms of Disease. 2:16012. DOI: 10.1038/npjamd.2016.12

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Prior, M., Goldberg, J., Chiruta, C., Farrokhi, C., Kopynets, M., Roberts, A.J., Schubert, D. Selecting for neurogenic potential as an alternative for Alzheimer's disease drug discovery. (2016) Alzheimers Dement. 12(6):678-86. DOI: 10.1016/j.jalz.2016.03.016

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Currais, A., Goldberg, J., Farrokhi, C., Chang, M., Prior, M., Dargusch, R., Daugherty, D., Armando, A., Quehenberger, O., Maher, P., Schubert, D. A comprehensive multiomics approach toward understanding the relationship between aging and dementia. (2015) Aging. 7(11):937-55. DOI: 10.18632/aging.100838

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Prior, M., Chiruta, C., Currais, A., Goldberg, J., Ramsey, J., Dargusch, R., Maher, P.A., Schubert, D. Back to the future with phenotypic screening. (2014) ACS Chem Neurosci. 5(7):503-13. DOI: 10.1021/cn500051h

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Currais, A., Prior, M., Dargusch, R., Armando, A., Ehren, J., Schubert, D., Quehenberger, O., Maher, P. Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. (2014) Aging Cell. 13(2):379-90. DOI: 10.1111/acel.12185

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Valera, E., Dargusch, R., Maher, P.A., Schubert, D. Modulation of 5-lipoxygenase in proteotoxicity and Alzheimer's disease. (2013) Journal of Neuroscience. 33(25):10512-25. DOI: 10.1523/JNEUROSCI.5183-12.2013

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Chiruta, C., Zhao, Y., Tang, F., Wang, T., Schubert, D. Metabolism of a potent neuroprotective hydrazide. (2013) Bioorganic & Medicinal Chemistry. 21(10):2733-41. DOI: 10.1016/j.bmc.2013.03.020

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Currais, A., Prior, M., Lo, D., Jolivalt, C., Schubert, D., Maher, P. Diabetes exacerbates amyloid and neurovascular pathology in aging-accelerated mice. (2012) Aging Cell. 11(6):1017-26. DOI: 10.1111/acel.12002

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Schubert, D., Maher, P. An alternative approach to drug discovery for Alzheimer's disease dementia. (2012) Future Medicinal Chemistry. 4(13):1681-8. DOI: 10.4155/fmc.12.109

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Narumoto, O., Matsuo, Y., Sakaguchi, M., Shoji, S., Yamashita, N., Schubert, D., Abe, K., Horiguchi, K., Nagase, T., Yamashita, N. Suppressive effects of a pyrazole derivative of curcumin on airway inflammation and remodeling. (2012) Exp. Mol. Pathol. 93(1):18-25. DOI: 10.1016/j.yexmp.2012.04.011

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Herrera, F., Maher, P., Schubert, D. c-Jun N-terminal kinase controls a negative loop in the regulation of glial fibrillary acidic protein expression by retinoic acid. (2012) Neuroscience. 208:143-9. DOI: 10.1016/j.neuroscience.2012.02.011

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Chiruta, C., Schubert, D., Dargusch, R., Maher, P. Chemical modification of the multitarget neuroprotective compound fisetin. (2012) Journal of Medicinal Chemistry. 55(1):378-89. DOI: 10.1021/jm2012563

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Chen, Q., Prior, M., Dargusch, R., Roberts, A., Riek, R., Eichmann, C., Chiruta, C., Akaishi, T., Abe, K., Maher, P., Schubert, D. A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. (2011) PLOS One. 6(12):e27865. DOI: 10.1371/journal.pone.0027865

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Maher, P., Dargusch, R., Ehren, J.L., Okada, S., Sharma, K., Schubert, D. Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. (2011) PLOS One. 6(6):e21226. DOI: 10.1371/journal.pone.0021226

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Bartlett, B.J., Isakson, P., Lewerenz, J., Sanchez, H., Kotzebue, R.W., Cumming, R.C., Harris, G.L., Nezis, I.P., Schubert, D.R., Simonsen, A., Finley, K.D. p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects. (2011) Autophagy. 7(6):572-83.

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Lapchak, P.A., Schubert, D.R., Maher, P.A. De-Risking of Stilbazulenyl Nitrone (STAZN), a Lipophilic Nitrone to Treat Stroke Using a Unique Panel of In Vitro Assays. (2011) Transl Stroke Res. 2(2):209-17. DOI: 10.1007/s12975-011-0071-7

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Wu, A., Ying, Z., Schubert, D., Gomez-Pinilla, F. Brain and spinal cord interaction: a dietary curcumin derivative counteracts locomotor and cognitive deficits after brain trauma. (2011) Neurorehabil Neural Repair. 25(4):332-42. DOI: 10.1177/1545968310397706

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Newington, J.T., Pitts, A., Chien, A., Arseneault, R., Schubert, D., Cumming, R.C. Amyloid beta resistance in nerve cell lines is mediated by the Warburg effect. (2011) PLOS One. 6(4):e19191. DOI: 10.1371/journal.pone.0019191

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Lapchak, P.A., Schubert, D.R., Maher, P.A. Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke. (2011) J. Neurochem. 116(1):122-31. DOI: 10.1111/j.1471-4159.2010.07090.x

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Herrera, F., Chen, Q., Schubert, D. Synergistic effect of retinoic acid and cytokines on the regulation of glial fibrillary acidic protein expression. (2010) Journal of Biological Chemistry. 285(50):38915-22. DOI: 10.1074/jbc.M110.170274

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Wang, L., Schubert, D., Sawaya, M.R., Eisenberg, D., Riek, R. Multidimensional structure-activity relationship of a protein in its aggregated states. (2010) Angew. Chem. Int. Ed. Engl. 49(23):3904-8. DOI: 10.1002/anie.201000068


Maher, P., Akaishi, T., Schubert, D., Abe, K. A pyrazole derivative of curcumin enhances memory. (2010) Neurobiology of Aging. 31(4):706-9. DOI: 10.1016/j.neurobiolaging.2008.05.020

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Burdo, J.R., Chen, Q., Calcutt, N.A., Schubert, D. The pathological interaction between diabetes and presymptomatic Alzheimer's disease. (2009) Neurobiology of Aging. 30(12):1910-7. DOI: 10.1016/j.neurobiolaging.2008.02.010

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Liu, Y., Schubert, D.R. The specificity of neuroprotection by antioxidants. (2009) J. Biomed. Sci. 16:98. DOI: 10.1186/1423-0127-16-98

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Lewerenz, J., Albrecht, P., Tien, M.L., Henke, N., Karumbayaram, S., Kornblum, H.I., Wiedau-Pazos, M., Schubert, D., Maher, P., Methner, A. Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro. (2009) J. Neurochem. 111(2):332-43. DOI: 10.1111/j.1471-4159.2009.06347.x

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Schubert, D. Commercialized GM crops and yield. (2009) Nature Biotechnology. 27(9):802-3; author reply 803. DOI: 10.1038/nbt0909-802


Maji, S.K., Perrin, M.H., Sawaya, M.R., Jessberger, S., Vadodaria, K., Rissman, R.A., Singru, P.S., Nilsson, K.P., Simon, R., Schubert, D., Eisenberg, D., Rivier, J., Sawchenko, P., Vale, W., Riek, R. Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. (2009) Science. 325(5938):328-32. DOI: 10.1126/science.1173155

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Herrera, F., Chen, Q., Fischer, W.H., Maher, P., Schubert, D.R. Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down's syndrome. (2009) Cell Death and Differentiation. 16(6):910-20. DOI: 10.1038/cdd.2009.24

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Maher, P.A., Schubert, D.R. Metabolic links between diabetes and Alzheimer's disease. (2009) Expert Rev Neurother. 9(5):617-30. DOI: 10.1586/ern.09.18

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Schubert, D., Soucek, T., Blouw, B. The induction of HIF-1 reduces astrocyte activation by amyloid beta peptide. (2009) Eur. J. Neurosci. 29(7):1323-34. DOI: 10.1111/j.1460-9568.2009.06712.x

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Schubert, D., Herrera, F., Cumming, R., Read, J., Low, W., Maher, P., Fischer, W.H. Neural cells secrete a unique repertoire of proteins. (2009) J. Neurochem. 109(2):427-35. DOI: 10.1111/j.1471-4159.2009.05968.x

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Chen, Q., Peto, C.A., Shelton, G.D., Mizisin, A., Sawchenko, P.E., Schubert, D. Loss of modifier of cell adhesion reveals a pathway leading to axonal degeneration. (2009) Journal of Neuroscience. 29(1):118-30. DOI: 10.1523/JNEUROSCI.3985-08.2009

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Schubert, D.R. The problem with nutritionally enhanced plants. (2008) J Med Food. 11(4):601-5. DOI: 10.1089/jmf.2008.0094

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Liu, Y., Dargusch, R., Maher, P., Schubert, D. A broadly neuroprotective derivative of curcumin. (2008) J. Neurochem. 105(4):1336-45. DOI: 10.1111/j.1471-4159.2008.05236.x

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Maji, S.K., Schubert, D., Rivier, C., Lee, S., Rivier, J.E., Riek, R. Amyloid as a depot for the formulation of long-acting drugs. (2008) PLOS Biology. 6(2):e17. DOI: 10.1371/journal.pbio.0060017

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Simonsen, A., Cumming, R.C., Brech, A., Isakson, P., Schubert, D.R., Finley, K.D. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. (2008) Autophagy. 4(2):176-84.

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Burdo, J., Schubert, D., Maher, P. Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons. (2008) Brain Research. 1189:12-22. DOI: 10.1016/j.brainres.2007.10.077

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Lapchak, P.A., Maher, P., Schubert, D., Zivin, J.A. Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes. (2007) Neuroscience. 150(3):585-91. DOI: 10.1016/j.neuroscience.2007.09.033

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Cumming, R.C., Dargusch, R., Fischer, W.H., Schubert, D. Increase in expression levels and resistance to sulfhydryl oxidation of peroxiredoxin isoforms in amyloid beta-resistant nerve cells. (2007) Journal of Biological Chemistry. 282(42):30523-34. DOI: 10.1074/jbc.M700869200

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Schubert, D. Two views of the emperor's new clones. (2007) Nature Biotechnology. 25(3):282-3. DOI: 10.1038/nbt0307-282


Schubert, D., Williams, D. 'Cisgenic' as a product designation. (2006) Nature Biotechnology. 24(11):1327-9; author reply 1331-3. DOI: 10.1038/nbt1106-1327


Liu, Y., Ritter, C., Riek, R., Schubert, D. The formation of bioactive amyloid species by prion proteins in vitro and in cells. (2006) Neurosci. Lett. 406(3):200-4. DOI: 10.1016/j.neulet.2006.07.047

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Diambra, L., Cintra, L.C., Chen, Q., Schubert, D., Costa, L.F. Cell adhesion protein decreases cell motion: Statistical characterization of locomotion activity (2006) Physica A: Statistical Mechanics and its Applications. 365(2):481-490. DOI: https://doi.org/10.1016/j.physa.2005.10.006

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Burdo, J., Dargusch, R., Schubert, D. Distribution of the cystine/glutamate antiporter system xc- in the brain, kidney, and duodenum. (2006) J. Histochem. Cytochem. 54(5):549-57. DOI: 10.1369/jhc.5A6840.2006

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Liu, Y., Schubert, D. Treating Alzheimer's disease by inactivating bioactive amyloid beta peptide. (2006) Current Alzheimer Research. 3(2):129-35.

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Schubert, D., Dargusch, R., Raitano, J., Chan, S.W. Cerium and yttrium oxide nanoparticles are neuroprotective. (2006) Biochemical and Biophysical Research Communications. 342(1):86-91. DOI: 10.1016/j.bbrc.2006.01.129

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Kimura, Y., Dargusch, R., Schubert, D., Kimura, H. Hydrogen sulfide protects HT22 neuronal cells from oxidative stress. (2006) Antioxid. Redox Signal. 8(3-4):661-70. DOI: 10.1089/ars.2006.8.661

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Schubert, D., Klar, A., Park, M., Dargusch, R., Fischer, W.H. F-spondin promotes nerve precursor differentiation. (2006) J. Neurochem. 96(2):444-53. DOI: 10.1111/j.1471-4159.2005.03563.x

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Cumming, R.C., Schubert, D. Amyloid-beta induces disulfide bonding and aggregation of GAPDH in Alzheimer's disease. (2005) FASEB Journal. 19(14):2060-2. DOI: 10.1096/fj.05-4195fje

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Costa, L.d.a.F., Cintra, L.C., Schubert, D. An integrated approach to the characterization of cell movement. (2005) Cytometry A. 68(2):92-100. DOI: 10.1002/cyto.a.20191

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Lührs, T., Ritter, C., Adrian, M., Riek-Loher, D., Bohrmann, B., Döbeli, H., Schubert, D., Riek, R. 3D structure of Alzheimer's amyloid-beta(1-42) fibrils. (2005) Proceedings of the National Academy of Sciences of the United States of America. 102(48):17342-7. DOI: 10.1073/pnas.0506723102

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Schubert, D. Regulatory regimes for transgenic crops. (2005) Nature Biotechnology. 23(7):785-7; author reply 787-9. DOI: 10.1038/nbt0705-785b


Schubert, D. Glucose metabolism and Alzheimer's disease. (2005) Ageing Research Reviews. 4(2):240-57. DOI: 10.1016/j.arr.2005.02.003

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Chen, Q., Chen, T.J., Letourneau, P.C., Costa, L.d.a.F., Schubert, D. Modifier of cell adhesion regulates N-cadherin-mediated cell-cell adhesion and neurite outgrowth. (2005) Journal of Neuroscience. 25(2):281-90. DOI: 10.1523/JNEUROSCI.3692-04.2005

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Liu, Y., Dargusch, R., Banh, C., Miller, C.A., Schubert, D. Detecting bioactive amyloid beta peptide species in Alzheimer's disease. (2004) J. Neurochem. 91(3):648-56. DOI: 10.1111/j.1471-4159.2004.02751.x

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Freese, W., Schubert, D. Safety testing and regulation of genetically engineered foods. (2004) Biotechnol. Genet. Eng. Rev. 21:299-324.


Cumming, R.C., Andon, N.L., Haynes, P.A., Park, M., Fischer, W.H., Schubert, D. Protein disulfide bond formation in the cytoplasm during oxidative stress. (2004) Journal of Biological Chemistry. 279(21):21749-58. DOI: 10.1074/jbc.M312267200

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Costa, L.d.a.F., Mutinari, G., Schubert, D. Characterizing width uniformity by wave propagation. (2003) Phys Rev E Stat Nonlin Soft Matter Phys. 68(5 Pt 2):056704. DOI: 10.1103/PhysRevE.68.056704

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Soucek, T., Cumming, R., Dargusch, R., Maher, P., Schubert, D. The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide. (2003) Neuron. 39(1):43-56. DOI: 10.1016/s0896-6273(03)00367-2

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Borghi, R., Venè, R., Arena, G., Schubert, D., Albini, A., Tosetti, F. Transient modulation of cytoplasmic and nuclear retinoid receptors expression in differentiating human teratocarcinoma NT2 cells. (2003) J. Neurochem. 84(1):94-104.

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Schubert, D. A different perspective on GM food. (2002) Nature Biotechnology. 20(10):969. DOI: 10.1038/nbt1002-969


Chen, Q., Schubert, D. Presenilin-interacting proteins. (2002) Expert Rev Mol Med. 4(19):1-18. DOI: doi:10.1017/S1462399402005008

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Chen, Q., Kimura, H., Schubert, D. A novel mechanism for the regulation of amyloid precursor protein metabolism. (2002) Journal of Cell Biology. 158(1):79-89. DOI: 10.1083/jcb.200110151

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Dargusch, R., Schubert, D. Specificity of resistance to oxidative stress. (2002) J. Neurochem. 81(6):1394-400.

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Liu, Y., Fiskum, G., Schubert, D. Generation of reactive oxygen species by the mitochondrial electron transport chain. (2002) J. Neurochem. 80(5):780-7.

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Tan, S., Schubert, D., Maher, P. Oxytosis: A novel form of programmed cell death. (2001) Current Topics in Medicinal Chemistry. 1(6):497-506.

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Chen, Q., Yoshida, H., Schubert, D., Maher, P., Mallory, M., Masliah, E. Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation. (2001) Am. J. Pathol. 159(5):1597-602. DOI: 10.1016/S0002-9440(10)63005-2

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Schubert, D., Piasecki, D. Oxidative glutamate toxicity can be a component of the excitotoxicity cascade. (2001) Journal of Neuroscience. 21(19):7455-62.

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Ishige, K., Chen, Q., Sagara, Y., Schubert, D. The activation of dopamine D4 receptors inhibits oxidative stress-induced nerve cell death. (2001) Journal of Neuroscience. 21(16):6069-76.

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Tan, S., Somia, N., Maher, P., Schubert, D. Regulation of antioxidant metabolism by translation initiation factor 2alpha. (2001) Journal of Cell Biology. 152(5):997-1006.

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Ishige, K., Schubert, D., Sagara, Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. (2001) Free Radical Biology & Medicine. 30(4):433-46.

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Dargusch, R., Piasecki, D., Tan, S., Liu, Y., Schubert, D. The role of Bax in glutamate-induced nerve cell death. (2001) J. Neurochem. 76(1):295-301.

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Maher, P., Schubert, D. Signaling by reactive oxygen species in the nervous system. (2000) Cellular and Molecular Life Sciences. 57(8-9):1287-305.

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Kashiwa, A., Yoshida, H., Lee, S., Paladino, T., Liu, Y., Chen, Q., Dargusch, R., Schubert, D., Kimura, H. Isolation and characterization of novel presenilin binding protein. (2000) J. Neurochem. 75(1):109-16.

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Sagara, Y., Hendler, S., Khoh-Reiter, S., Gillenwater, G., Carlo, D., Schubert, D., Chang, J. Propofol hemisuccinate protects neuronal cells from oxidative injury. (1999) J. Neurochem. 73(6):2524-30.

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Li, Y., Xu, C., Schubert, D. The up-regulation of endosomal-lysosomal components in amyloid beta-resistant cells. (1999) J. Neurochem. 73(4):1477-82.

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Liu, Y., Schubert, D. Steroid hormones block amyloid fibril-induced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) formazan exocytosis: relationship to neurotoxicity. (1998) J. Neurochem. 71(6):2322-9.

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Liu, Y., Peterson, D.A., Schubert, D. Amyloid beta peptide alters intracellular vesicle trafficking and cholesterol homeostasis. (1998) Proceedings of the National Academy of Sciences of the United States of America. 95(22):13266-71.

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Sagara, Y., Schubert, D. The activation of metabotropic glutamate receptors protects nerve cells from oxidative stress. (1998) Journal of Neuroscience. 18(17):6662-71.

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Sagara, Y., Dargusch, R., Chambers, D., Davis, J., Schubert, D., Maher, P. Cellular mechanisms of resistance to chronic oxidative stress. (1998) Free Radical Biology & Medicine. 24(9):1375-89.

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Tan, S., Sagara, Y., Liu, Y., Maher, P., Schubert, D. The regulation of reactive oxygen species production during programmed cell death. (1998) Journal of Cell Biology. 141(6):1423-32.

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Li, Y., Maher, P., Schubert, D. Phosphatidylcholine-specific phospholipase C regulates glutamate-induced nerve cell death. (1998) Proceedings of the National Academy of Sciences of the United States of America. 95(13):7748-53. DOI: 10.1073/pnas.95.13.7748

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Sagara, Y., Tan, S., Maher, P., Schubert, D. Mechanisms of resistance to oxidative stress in Alzheimer's disease. (1998) Biofactors. 8(1-2):45-50.

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Li, Y., Maher, P., Schubert, D. Requirement for cGMP in nerve cell death caused by glutathione depletion. (1997) Journal of Cell Biology. 139(5):1317-24.

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Liu, Y., Schubert, D. Cytotoxic amyloid peptides inhibit cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction by enhancing MTT formazan exocytosis. (1997) J. Neurochem. 69(6):2285-93.

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Tan, S., Maher, P., Schubert, D. The role of protein phosphorylation in beta amyloid toxicity. (1997) Brain Research. 765(1):159-63.

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Liu, Y., Dargusch, R., Schubert, D. Beta amyloid toxicity does not require RAGE protein. (1997) Biochemical and Biophysical Research Communications. 237(1):37-40. DOI: 10.1006/bbrc.1997.7068

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Li, Y., Maher, P., Schubert, D. A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion. (1997) Neuron. 19(2):453-63.

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Liu, Y., Peterson, D.A., Kimura, H., Schubert, D. Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction. (1997) J. Neurochem. 69(2):581-93.

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Schubert, D. Serpins inhibit the toxicity of amyloid peptides. (1997) European Journal of Neuroscience. 9(4):770-7.

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Fischer, W.H., Schubert, D. Characterization of a novel platelet-derived growth factor-associated protein. (1996) J. Neurochem. 66(5):2213-6.

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Sagara, Y., Dargusch, R., Klier, F.G., Schubert, D., Behl, C. Increased antioxidant enzyme activity in amyloid beta protein-resistant cells. (1996) Journal of Neuroscience. 16(2):497-505.

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Schubert, D., Chevion, M. The role of iron in beta amyloid toxicity. (1995) Biochemical and Biophysical Research Communications. 216(2):702-7. DOI: 10.1006/bbrc.1995.2678

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Maher, P.A., Schubert, D. Schwannoma-derived growth factor interacts with the epidermal growth factor receptor. (1995) J. Neurochem. 65(4):1895-8.

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Schubert, D., Behl, C., Lesley, R., Brack, A., Dargusch, R., Sagara, Y., Kimura, H. Amyloid peptides are toxic via a common oxidative mechanism. (1995) Proceedings of the National Academy of Sciences of the United States of America. 92(6):1989-93.

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Jin, L.W., Ninomiya, H., Roch, J.M., Schubert, D., Masliah, E., Otero, D.A., Saitoh, T. Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension. (1994) Journal of Neuroscience. 14(9):5461-70.

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Behl, C., Davis, J.B., Lesley, R., Schubert, D. Hydrogen peroxide mediates amyloid beta protein toxicity. (1994) Cell. 77(6):817-27.

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Behl, C., Davis, J.B., Klier, F.G., Schubert, D. Amyloid beta peptide induces necrosis rather than apoptosis. (1994) Brain Research. 645(1-2):253-64.

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Behl, C., Hovey, L., Krajewski, S., Schubert, D., Reed, J.C. BCL-2 prevents killing of neuronal cells by glutamate but not by amyloid beta protein. (1993) Biochemical and Biophysical Research Communications. 197(2):949-56. DOI: 10.1006/bbrc.1993.2571

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Schubert, D., Behl, C. The expression of amyloid beta protein precursor protects nerve cells from beta-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix. (1993) Brain Research. 629(2):275-82.

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Roch, J.M., Jin, L.W., Ninomiya, H., Schubert, D., Saitoh, T. Biologically active domain of the secreted form of the amyloid beta/A4 protein precursor. (1993) Ann. N. Y. Acad. Sci. 695:149-57.

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Kimura, H., Schubert, D. Amyloid beta-protein activates tachykinin receptors and inositol trisphosphate accumulation by synergy with glutamate. (1993) Proceedings of the National Academy of Sciences of the United States of America. 90(16):7508-12.

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Behl, C., Schubert, D. Heat shock partially protects rat pheochromocytoma PC12 cells from amyloid beta peptide toxicity. (1993) Neurosci. Lett. 154(1-2):1-4.

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Davis, J.B., McMurray, H.F., Schubert, D. The amyloid beta-protein of Alzheimer's disease is chemotactic for mononuclear phagocytes. (1992) Biochemical and Biophysical Research Communications. 189(2):1096-100.

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Schubert, D., Kimura, H., Maher, P. Growth factors and vitamin E modify neuronal glutamate toxicity. (1992) Proceedings of the National Academy of Sciences of the United States of America. 89(17):8264-7.

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Behl, C., Davis, J., Cole, G.M., Schubert, D. Vitamin E protects nerve cells from amyloid beta protein toxicity. (1992) Biochemical and Biophysical Research Communications. 186(2):944-50.

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Schubert, D. Collaborative interactions between growth factors and the extracellular matrix. (1992) Trends in Cell Biology. 2(3):63-6.

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Schubert, D. Synergistic interactions between transforming growth factor beta and fibroblast growth factor regulate Schwann cell mitosis. (1992) Journal of Neurobiology. 23(2):143-8. DOI: 10.1002/neu.480230205

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Kimura, H., Schubert, D. Schwannoma-derived growth factor promotes the neuronal differentiation and survival of PC12 cells. (1992) Journal of Cell Biology. 116(3):777-83.

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Engele, J., Schubert, D., Bohn, M.C. Conditioned media derived from glial cell lines promote survival and differentiation of dopaminergic neurons in vitro: role of mesencephalic glia. (1991) Journal of Neuroscience Research. 30(2):359-71. DOI: 10.1002/jnr.490300212

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Schubert, D., Kimura, H. Substratum-growth factor collaborations are required for the mitogenic activities of activin and FGF on embryonal carcinoma cells. (1991) Journal of Cell Biology. 114(4):841-6.

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Schubert, D., Klier, F.G. Substratum regulation of neurite fasciculation. (1991) Brain Research. 549(2):305-10.

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Schubert, D. The possible role of adhesion in synaptic modification. (1991) Trends in Neurosciences. 14(4):127-30.


Kimura, H., Fischer, W.H., Schubert, D. Structure, expression and function of a schwannoma-derived growth factor. (1990) Nature. 348(6298):257-60. DOI: 10.1038/348257a0

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Svrzic, D., Schubert, D. Insulin-like growth factor 1 supports embryonic nerve cell survival. (1990) Biochemical and Biophysical Research Communications. 172(1):54-60.

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Klier, F.G., Cole, G., Stallcup, W., Schubert, D. Amyloid beta-protein precursor is associated with extracellular matrix. (1990) Brain Research. 515(1-2):336-42.

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Schubert, D., Kimura, H., LaCorbiere, M., Vaughan, J., Karr, D., Fischer, W.H. Activin is a nerve cell survival molecule. (1990) Nature. 344(6269):868-70. DOI: 10.1038/344868a0

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Schubert, D., Jin, L.W., Saitoh, T., Cole, G. The regulation of amyloid beta protein precursor secretion and its modulatory role in cell adhesion. (1989) Neuron. 3(6):689-94.

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Schubert, D. The biological roles of heparan sulfate proteoglycans in the nervous system. (1989) Neurobiology of Aging. 10(5):504-6; discussion 510-2.

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Saitoh, T., Sundsmo, M., Roch, J.M., Kimura, N., Cole, G., Schubert, D., Oltersdorf, T., Schenk, D.B. Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts. (1989) Cell. 58(4):615-22.

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Schubert, D., Cole, G., Saitoh, T., Oltersdorf, T. Amyloid beta protein precursor is a mitogen. (1989) Biochemical and Biophysical Research Communications. 162(1):83-8.

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Schubert, D. Response: relation of the amyloid i8 protein precursor to heparan sulfate proteoglycans. (1989) Science. 244(4906):827-8. DOI: 10.1126/science.244.4906.827


Schubert, D., LaCorbiere, M., Saitoh, T., Cole, G. Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate. (1989) Proceedings of the National Academy of Sciences of the United States of America. 86(6):2066-9.

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Le Beau, J.M., LaCorbiere, M., Powell, H.C., Ellisman, M.H., Schubert, D. Extracellular fluid conditioned during peripheral nerve regeneration stimulates Schwann cell adhesion, migration and proliferation. (1988) Brain Research. 459(1):93-104.

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Schubert, D., Schroeder, R., LaCorbiere, M., Saitoh, T., Cole, G. Amyloid beta protein precursor is possibly a heparan sulfate proteoglycan core protein. (1988) Science. 241(4862):223-6.

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Tsui, H.C., Schubert, D., Klein, W.L. Molecular basis of growth cone adhesion: anchoring of adheron-containing filaments at adhesive loci. (1988) Journal of Cell Biology. 106(6):2095-108.

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Baird, A., Schubert, D., Ling, N., Guillemin, R. Receptor- and heparin-binding domains of basic fibroblast growth factor. (1988) Proceedings of the National Academy of Sciences of the United States of America. 85(7):2324-8.

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Berman, P., Gray, P., Chen, E., Keyser, K., Ehrlich, D., Karten, H., LaCorbiere, M., Esch, F., Schubert, D. Sequence analysis, cellular localization, and expression of a neuroretina adhesion and cell survival molecule. (1987) Cell. 51(1):135-42.

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Schubert, D., Ling, N., Baird, A. Multiple influences of a heparin-binding growth factor on neuronal development. (1987) Journal of Cell Biology. 104(3):635-43.

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Schubert, D., Brass, B., Dumas, J.P. Protein complexity of central nervous system cell lines. (1986) Journal of Neuroscience. 6(10):2829-36.

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Schubert, D., LaCorbiere, M., Esch, F. A chick neural retina adhesion and survival molecule is a retinol-binding protein. (1986) Journal of Cell Biology. 102(6):2295-301.

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Schubert, D., LaCorbiere, M. Role of purpurin in neural retina histogenesis. (1986) Prog. Clin. Biol. Res. 217B:3-16.


Kruijer, W., Schubert, D., Verma, I.M. Induction of the proto-oncogene fos by nerve growth factor. (1985) Proceedings of the National Academy of Sciences of the United States of America. 82(21):7330-4.

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Schubert, D., Stallcup, W., LaCorbiere, M., Kidokoro, Y., Orgel, L. Ontogeny of electrically excitable cells in cultured olfactory epithelium. (1985) Proceedings of the National Academy of Sciences of the United States of America. 82(22):7782-6.

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Schubert, D., LaCorbiere, M. Isolation of an adhesion-mediating protein from chick neural retina adherons. (1985) Journal of Cell Biology. 101(3):1071-7.

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Deschamps, J., Mitchell, R.L., Meijlink, F., Kruijer, W., Schubert, D., Verma, I.M. Proto-oncogene fos is expressed during development, differentiation, and growth. (1985) Cold Spring Harbor Symposia on Quantitative Biology. 50:733-45.


Cole, G.J., Schubert, D., Glaser, L. Cell-substratum adhesion in chick neural retina depends upon protein-heparan sulfate interactions. (1985) Journal of Cell Biology. 100(4):1192-9.

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Schubert, D., LaCorbiere, M. Isolation of a cell-surface receptor for chick neural retina adherons. (1985) Journal of Cell Biology. 100(1):56-63.

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Traynor, A.E., Schubert, D. Phospholipases elevate cyclic AMP levels and promote neurite extension in a clonal nerve cell line. (1984) Brain Research. 316(2):197-204.

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Schubert, D., LaCorbiere, M., Klier, F.G., Birdwell, C. The structure and function of myoblast adherons. (1983) Cold Spring Harbor Symposia on Quantitative Biology. 48 Pt 2:539-49.


Schubert, D., LaCorbiere, M., Klier, F.G., Birdwell, C. A role for adherons in neural retina cell adhesion. (1983) Journal of Cell Biology. 96(4):990-8.

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Traynor, A.E., Schubert, D., Allen, W.R. Alterations of lipid metabolism in response to nerve growth factor. (1982) J. Neurochem. 39(6):1677-83.

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Schubert, D., LaCorbiere, M. Properties of extracellular adhesion-mediating particles in myoblast clone and its adhesion-deficient variant. (1982) Journal of Cell Biology. 94(1):108-114.

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Schubert, D., LaCorbiere, M. The specificity of extracellular glycoprotein complexes in mediating cellular adhesion. (1982) Journal of Neuroscience. 2(1):82-9.

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LaCorbiere, M., Schubert, D. The role of cAMP in the induction of ornithine decarboxylase by nerve and epidermal growth factors. (1981) Journal of Neuroscience Research. 6(2):211-6. DOI: 10.1002/jnr.490060207

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Schubert, D., LaCorbiere, M. A role of secreted glycosaminoglycans in cell-substratum adhesion. (1980) Journal of Biological Chemistry. 255(23):11564-9.

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Schubert, D., LaCorbiere, M. Altered collagen and glycosaminoglycan secretion by a skeletal muscle myoblast variant. (1980) Journal of Biological Chemistry. 255(23):11557-63.

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Schubert, D., LaCorbiere, M. Role of a 16S glycoprotein complex in cellular adhesion. (1980) Proceedings of the National Academy of Sciences of the United States of America. 77(7):4137-41.

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Schubert, D., LaCorbiere, M., Klier, F.G., Steinbach, J.H. The modulation of neurotransmitter synthesis by steroid hormones and insulin. (1980) Brain Research. 190(1):67-79.

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Steinbach, J.H., Schubert, D., Eldridge, L. Changes in cat muscle contractile proteins after prolonged muscle inactivity. (1980) Exp. Neurol. 67(3):655-69.


Napias, C., Olsen, R.W., Schubert, D. GABA and picrotoxinin receptors in clonal nerve cells. (1980) Nature. 283(5744):298-9.


Schubert, D. Insulin-induced cell-substratum adhesion. (1979) Experimental Cell Research. 124(2):446-51.


Lennon, V.A., Peterson, S., Schubert, D. Neurectoderm markers retained in phenotypical skeletal muscle cells arising from a glial cell line. (1979) Nature. 281(5732):586-8.


Garrels, J.I., Schubert, D. Modulation of protein synthesis by nerve growth factor. (1979) Journal of Biological Chemistry. 254(16):7978-85.

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Schubert, D., Carlisle, W. Neuronal cells from rodent neoplasms. (1979) Meth. Enzymol. 58:584-90.


Schubert, D. Early events after the interaction of NGF with sympathetic nerve cells (1979) Trends in Neurosciences. 2:17-20. DOI: https://doi.org/10.1016/0166-2236(79)90009-2

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Schubert, D. NGF-induced alterations in protein secretion and substrate-attached material of a clonal nerve cell line. (1978) Brain Research. 155(1):196-200.


Schubert, D., LaCorbiere, M., Whitlock, C., Stallcup, W. Alterations in the surface properties of cells responsive to nerve growth factor. (1978) Nature. 273(5665):718-23.

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Patrick, J., Heinemann, S., Schubert, D. Biology of cultured nerve and muscle. (1978) Annual Review of Neuroscience. 1:417-43. DOI: 10.1146/annurev.ne.01.030178.002221

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Schubert, D., Klier, F.G. Storage and release of acetylcholine by a clonal cell line. (1977) Proceedings of the National Academy of Sciences of the United States of America. 74(11):5184-8.

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Schubert, D., Whitlock, C. Alteration of cellular adhesion by nerve growth factor. (1977) Proceedings of the National Academy of Sciences of the United States of America. 74(9):4055-8.

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Schubert, D. The substrate attached material synthesized by clonal cell lines of nerve, glia, and muscle. (1977) Brain Research. 132(2):337-46.

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Klier, F.G., Schubert, D., Heinemann, S. The ultrastructural differentiation of the clonal myogenic cell line L6 in normal and high K+ medium. (1977) Developmental Biology. 57(2):440-9.


Schubert, D., Heinemann, S., Kidokoro, Y. Cholinergic metabolism and synapse formation by a rat nerve cell line. (1977) Proceedings of the National Academy of Sciences of the United States of America. 74(6):2579-83.

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Schubert, D., Lacorbiere, M., Watson, J. Growth regulation of cells grown in suspension culture. (1976) Nature. 264(5583):266-7.


Schubert, D. Proteins secreted by clonal cell lines. Changes in metabolism with culture growth. (1976) Experimental Cell Research. 102(2):329-40.


Schubert, D., Lacorbiere, M. Phenotypic transformation of clonal myogenic cells to cells resembling chondrocytes. (1976) Proceedings of the National Academy of Sciences of the United States of America. 73(6):1989-93.

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Schubert, D., Tarikas, H., LaCorbiere, M. Neurotransmitter regulation of adenosine 3',5'-monophosphate in clonal nerve, glia, and muscle cell lines. (1976) Science. 192(4238):471-3.

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Kidokoro, Y., Heinemann, S., Schubert, D., Brandt, B.L., Klier, F.G. Synapse formation and neurotrophic effects on muscle cell lines. (1976) Cold Spring Harbor Symposia on Quantitative Biology. 40:373-88.


Schubert, D., Carlisle, W., Look, C. Putative neurotransmitters in clonal cell lines. (1975) Nature. 254(5498):341-3.


Steinbach, J.H., Schubert, D. Multiple modes of dibutyryl cyclic AMP-induced process formation by clonal nerve and glial cells. (1975) Experimental Cell Research. 91(2):449-53.


Klier, G., Schubert, D., Heinemann, S. Ultrastructural changes accompanying the induced differentiation of clonal rat nerve and glia. (1975) Neurobiology. 5(1):1-7.

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Schubert, D. The uptake of GABA by clonal nerve glia. (1975) Brain Research. 84(1):87-98.

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Kimes, B., Tarikas, H., Schubert, D. Neurotransmitter synthesis by two clonal nerve cell lines: changes with culture growth and morphological differentiation. (1974) Brain Research. 79(2):291-5.


Tarikas, H., Schubert, D. Regulation of adenylate kinase and creatine kinase activities in myogenic cells. (1974) Proceedings of the National Academy of Sciences of the United States of America. 71(6):2377-81.

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Schubert, D., Heinemann, S., Carlisle, W., Tarikas, H., Kimes, B., Patrick, J., Steinbach, J.H., Culp, W., Brandt, B.L. Clonal cell lines from the rat central nervous system. (1974) Nature. 249(454):224-7.


Schubert, D., Harris, A.J., Devine, C.E., Heinemann, S. Characterization of a unique muscle cell line. (1974) Developmental Biology. 61(2):398-413.

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Schubert, D. Induced differentiation of clonal rat nerve and glial cells. (1974) Neurobiology. 4(6):376-87.


Steinbach, J.H., Schubert, D., Tarikas, H. Inhibition of acetylcholine synthesis in neuroblastoma cells by a styrylpyridine analog. (1974) J. Neurochem. 22(4):611-3.


Steinbach, J.H., Harris, A.J., Patrick, J., Schubert, D., Heinemann, S. Nerve-muscle interaction in vitro. Role of acetylcholine. (1973) J. Gen. Physiol. 62(3):255-70.

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Schubert, D., Tarikas, H., Humphreys, S., Heinemann, S., Patrick, J. Protein synthesis and secretion in a myogenic cell line. (1973) Developmental Biology. 33(1):18-37.


Schubert, D. Protein secretion by clonal glial and neuronal cell lines. (1973) Brain Research. 56:387-91.


Patrick, J., Heinemann, S.F., Lindstrom, J., Schubert, D., Steinbach, J.H. Appearance of acetylcholine receptors during differentiation of a myogenic cell line. (1972) Proceedings of the National Academy of Sciences of the United States of America. 69(10):2762-6.

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Schubert, D., Tarikas, H., Harris, A.J., Heinemann, S. Induction of acetylcholine esterase activity in a mouse neuroblastoma. (1971) Nature. 233(37):79-80.


Schubert, D., Humphreys, S., Jacob, F., de Vitry, F. Induced differentiation of a neuroblastoma. (1971) Developmental Biology. 25(4):514-46.


Harris, A.J., Heinemann, S., Schubert, D., Tarakis, H. Trophic interaction between cloned tissue culture lines of nerve and muscle. (1971) Nature. 231(5301):296-301.


Schubert, D., Frank, H. Properties of particles aggregated from protein subunits of bacteriophage fr. (1971) Virology. 43(1):41-50.


Schubert, D., Cohn, M. Immunoglobulin biosynthesis. V. Light chain assembly. (1970) Journal of Molecular Biology. 53(3):305-20.


Schubert, D., Jacob, F. 5-bromodeoxyuridine-induced differentiation of a neuroblastoma. (1970) Proceedings of the National Academy of Sciences of the United States of America. 67(1):247-54.

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Schubert, D. Immunoglobulin biosynthesis. IV. Carbohydrate attachment to immunoglobulin subunits. (1970) Journal of Molecular Biology. 51(2):287-301.


Schubert, D., Roman, A., Cohn, M. Anti-nucleic acid specificites of mouse myeloma immunoglobulins. (1970) Nature. 225(5228):154-8.


Schubert, D., Humphreys, S., Baroni, C., Cohn, M. In vitro differentiation of a mouse neuroblastoma. (1969) Proceedings of the National Academy of Sciences of the United States of America. 64(1):316-23.

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Schubert, D., Cohn, M. Immunoglobulin biosynthesis. 3. Blocks in defective synthesis. (1968) Journal of Molecular Biology. 38(3):273-88.


Schubert, D., Horibata, K. Immunoglobulin biosynthesis. II. Four independently isolated myeloma variants. (1968) Journal of Molecular Biology. 38(3):263-71.


Schubert, D., Munro, A., Ohno, S. Immunoglobulin biosynthesis. I. A myeloma variant secreting light chain only. (1968) Journal of Molecular Biology. 38(3):253-62.


Schubert, D., Jobe, A., Cohn, M. Mouse myelomas producing precipitating antibody to nucleic acid bases and-or nitrophenyl derivatives. (1968) Nature. 220(5170):882-5.


Schubert, D. Immunoglobulin assembly in a mouse myeloma. (1968) Proceedings of the National Academy of Sciences of the United States of America. 60(2):683-90.


Prior, M., Dargusch, R., Ehren, J.L., Chiruta, C., Schubert, D. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. (n.d.) Alzheimers Res Ther. 5(3):25. DOI: 10.1186/alzrt179

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Education

BA, Chemistry, Indiana University
Graduate student with Mel Cohn, Salk Institute
PhD, Cell Biology, UCSD
Postdoctoral Fellow, Cell Biology, Nobel Laureate Francois Jacob, Pasteur Institute, Paris


Awards & Honors

  • 1993 Jacob Javits Award
  • Zenith Award, Alzheimer's Association
  • 1986 Jacob Javits Award