Björn Lillemeier

Associate Professor

NOMIS Center for Immunobiology and Microbial Pathogenesis

Waitt Advanced Biophotonics Center

Salk Institute for Biological Studies - Publications

all Publications


Katz, Z.B., Novotná, L., Blount, A., Lillemeier, B.F. A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli. (2017) Nat. Immunol. 18(1):86-95. DOI: 10.1038/ni.3631

+ expand abstract


Hu, Y.S., Cang, H., Lillemeier, B.F. Superresolution imaging reveals nanometer- and micrometer-scale spatial distributions of T-cell receptors in lymph nodes. (2016) Proc. Natl. Acad. Sci. U.S.A. 113(26):7201-6. DOI: 10.1073/pnas.1512331113

+ expand abstract


Maity, P.C., Blount, A., Jumaa, H., Ronneberger, O., Lillemeier, B.F., Reth, M. B cell antigen receptors of the IgM and IgD classes are clustered in different protein islands that are altered during B cell activation. (2015) Sci Signal. 8(394):ra93. DOI: 10.1126/scisignal.2005887

+ expand abstract


Klammt, C., Novotná, L., Li, D.T., Wolf, M., Blount, A., Zhang, K., Fitchett, J.R., Lillemeier, B.F. T cell receptor dwell times control the kinase activity of Zap70. (2015) Nat. Immunol. 16(9):961-9. DOI: 10.1038/ni.3231

+ expand abstract


Heimbucher, T., Liu, Z., Bossard, C., McCloskey, R., Carrano, A.C., Riedel, C.G., Tanasa, B., Klammt, C., Fonslow, B.R., Riera, C.E., Lillemeier, B.F., Kemphues, K., Yates, J.R., O, C., Hunter, T., Dillin, A. The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity. (2015) Cell Metab. 22(1):151-63. DOI: 10.1016/j.cmet.2015.06.002

+ expand abstract


Roh, K.H., Lillemeier, B.F., Wang, F., Davis, M.M. The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck. (2015) Proc. Natl. Acad. Sci. U.S.A. 112(13):E1604-13. DOI: 10.1073/pnas.1503532112

+ expand abstract


Kasuboski, J.M., Sigal, Y.J., Joens, M.S., Lillemeier, B.F., Fitzpatrick, J.A. Super-resolution microscopy: a comparative treatment. (2012) Curr Protoc Cytom. Chapter 2:Unit2.17. DOI: 10.1002/0471142956.cy0217s62

+ expand abstract


Klammt, C., Lillemeier, B.F. How membrane structures control T cell signaling. (2012) Front Immunol. 3:291. DOI: 10.3389/fimmu.2012.00291

+ expand abstract


Fitzpatrick, J.A., Lillemeier, B.F. Fluorescence correlation spectroscopy: linking molecular dynamics to biological function in vitro and in situ. (2011) Curr. Opin. Struct. Biol. 21(5):650-60. DOI: 10.1016/j.sbi.2011.06.006

+ expand abstract


Lillemeier, B.F., Davis, M.M. Probing the plasma membrane structure of immune cells through the analysis of membrane sheets by electron microscopy. (2011) Methods in molecular biology. 748:169-82. DOI: 10.1007/978-1-61779-139-0_12

+ expand abstract


Kuhns, M.S., Girvin, A.T., Klein, L.O., Chen, R., Jensen, K.D., Newell, E.W., Huppa, J.B., Lillemeier, B.F., Huse, M., Chien, Y.H., Garcia, K.C., Davis, M.M. Evidence for a functional sidedness to the alphabetaTCR. (2010) Proc. Natl. Acad. Sci. U.S.A. 107(11):5094-9. DOI: 10.1073/pnas.1000925107

+ expand abstract


Huppa, J.B., Axmann, M., Mörtelmaier, M.A., Lillemeier, B.F., Newell, E.W., Brameshuber, M., Klein, L.O., Schütz, G.J., Davis, M.M. TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity. (2010) Nature. 463(7283):963-7. DOI: 10.1038/nature08746

+ expand abstract


Lillemeier, B.F., Mörtelmaier, M.A., Forstner, M.B., Huppa, J.B., Groves, J.T., Davis, M.M. TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation. (2010) Nat. Immunol. 11(1):90-6. DOI: 10.1038/ni.1832

+ expand abstract


Lillemeier, B.F., Pfeiffer, J.R., Surviladze, Z., Wilson, B.S., Davis, M.M. Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton. (2006) Proc. Natl. Acad. Sci. U.S.A. 103(50):18992-7. DOI: 10.1073/pnas.0609009103

+ expand abstract


Huse, M., Lillemeier, B.F., Kuhns, M.S., Chen, D.S., Davis, M.M. T cells use two directionally distinct pathways for cytokine secretion. (2006) Nat. Immunol. 7(3):247-55. DOI: 10.1038/ni1304

+ expand abstract


Kerr, I.M., Costa-Pereira, A.P., Lillemeier, B.F., Strobl, B. Of JAKs, STATs, blind watchmakers, jeeps and trains. (2003) FEBS Letters. 546(1):1-5.

+ expand abstract


Hilkens, C.M., Is'harc, H., Lillemeier, B.F., Strobl, B., Bates, P.A., Behrmann, I., Kerr, I.M. A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130. (2001) FEBS Lett. 505(1):87-91.

+ expand abstract


van Ham, M., van Lith, M., Lillemeier, B., Tjin, E., Grüneberg, U., Rahman, D., Pastoors, L., van Meijgaarden, K., Roucard, C., Trowsdale, J., Ottenhoff, T., Pappin, D., Neefjes, J. Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO. (2000) J. Exp. Med. 191(7):1127-36.

+ expand abstract


van Ham, S.M., Tjin, E.P., Lillemeier, B.F., Grüneberg, U., van Meijgaarden, K.E., Pastoors, L., Verwoerd, D., Tulp, A., Canas, B., Rahman, D., Ottenhoff, T.H., Pappin, D.J., Trowsdale, J., Neefjes, J. HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading. (1997) Curr. Biol. 7(12):950-7.

+ expand abstract


Education

Undergraduate degree in Biochemistry, Free University Berlin (Germany) and Cancer Research UK (formerly Imperial Cancer Research Fund, U.K.)
PhD, Biochemistry, Cancer Research UK (formerly Imperial Cancer Research Fund) and University College London (U.K.)
Postdoctoral Fellow, Stanford University (U.S.A.)


Awards & Honors

  • 2013 Helen McLoraine Developmental Chair
  • 2012 NIH Director's New Innovator Award
  • 2010 Rudolph and Sletten Developmental Chair
  • 2002 Human Frontier Science Program Fellowship
  • 1997 Böhringer Ingelheim Fonds Scholarship
  • 1996 Dr. Carl Duisberg Stiftung Scholarship