Björn Lillemeier

Associate Professor
NOMIS Center for Immunobiology and Microbial Pathogenesis
Waitt Advanced Biophotonics Center

Salk Institute for Biological Studies - Publications

all Publications


Katz, Z.B., Zhang, C., Quintana, A., Lillemeier, B.F., Hogan, P.G. Septins organize endoplasmic reticulum-plasma membrane junctions for STIM1-ORAI1 calcium signalling. (2019) Scientific Reports. 9(1):10839. DOI: 10.1038/s41598-019-46862-w

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Xie, J., Han, X., Zhao, C., Canonigo-Balancio, A.J., Yates, J.R., Li, Y., Lillemeier, B.F., Altman, A. Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling. (2019) Science Signaling. 12(577). DOI: 10.1126/scisignal.aar3349

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Katz, Z.B., Novotná, L., Blount, A., Lillemeier, B.F. A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli. (2017) Nature Immunology. 18(1):86-95. DOI: 10.1038/ni.3631

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Hu, Y.S., Cang, H., Lillemeier, B.F. Superresolution imaging reveals nanometer- and micrometer-scale spatial distributions of T-cell receptors in lymph nodes. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(26):7201-6. DOI: 10.1073/pnas.1512331113

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Maity, P.C., Blount, A., Jumaa, H., Ronneberger, O., Lillemeier, B.F., Reth, M. B cell antigen receptors of the IgM and IgD classes are clustered in different protein islands that are altered during B cell activation. (2015) Science Signaling. 8(394):ra93. DOI: 10.1126/scisignal.2005887

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Klammt, C., Novotná, L., Li, D.T., Wolf, M., Blount, A., Zhang, K., Fitchett, J.R., Lillemeier, B.F. T cell receptor dwell times control the kinase activity of Zap70. (2015) Nature Immunology. 16(9):961-9. DOI: 10.1038/ni.3231

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Heimbucher, T., Liu, Z., Bossard, C., McCloskey, R., Carrano, A.C., Riedel, C.G., Tanasa, B., Klammt, C., Fonslow, B.R., Riera, C.E., Lillemeier, B.F., Kemphues, K., Yates, J.R., O, C., Hunter, T., Dillin, A. The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity. (2015) Cell Metabolism. 22(1):151-63. DOI: 10.1016/j.cmet.2015.06.002

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Roh, K.H., Lillemeier, B.F., Wang, F., Davis, M.M. The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck. (2015) Proceedings of the National Academy of Sciences of the United States of America. 112(13):E1604-13. DOI: 10.1073/pnas.1503532112

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Kasuboski, J.M., Sigal, Y.J., Joens, M.S., Lillemeier, B.F., Fitzpatrick, J.A. Super-resolution microscopy: a comparative treatment. (2012) Current Protocols in Cytometry. Chapter 2:Unit2.17. DOI: 10.1002/0471142956.cy0217s62

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Klammt, C., Lillemeier, B.F. How membrane structures control T cell signaling. (2012) Frontiers in Immunology. 3:291. DOI: 10.3389/fimmu.2012.00291

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Fitzpatrick, J.A., Lillemeier, B.F. Fluorescence correlation spectroscopy: linking molecular dynamics to biological function in vitro and in situ. (2011) Current Opinion in Structural Biology. 21(5):650-60. DOI: 10.1016/j.sbi.2011.06.006

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Lillemeier, B.F., Davis, M.M. Probing the plasma membrane structure of immune cells through the analysis of membrane sheets by electron microscopy. (2011) Methods in Molecular Biology. 748:169-82. DOI: 10.1007/978-1-61779-139-0_12

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Kuhns, M.S., Girvin, A.T., Klein, L.O., Chen, R., Jensen, K.D., Newell, E.W., Huppa, J.B., Lillemeier, B.F., Huse, M., Chien, Y.H., Garcia, K.C., Davis, M.M. Evidence for a functional sidedness to the alphabetaTCR. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(11):5094-9. DOI: 10.1073/pnas.1000925107

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Huppa, J.B., Axmann, M., Mörtelmaier, M.A., Lillemeier, B.F., Newell, E.W., Brameshuber, M., Klein, L.O., Schütz, G.J., Davis, M.M. TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity. (2010) Nature. 463(7283):963-7. DOI: 10.1038/nature08746

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Lillemeier, B.F., Mörtelmaier, M.A., Forstner, M.B., Huppa, J.B., Groves, J.T., Davis, M.M. TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation. (2010) Nature Immunology. 11(1):90-6. DOI: 10.1038/ni.1832

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Lillemeier, B.F., Pfeiffer, J.R., Surviladze, Z., Wilson, B.S., Davis, M.M. Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(50):18992-7. DOI: 10.1073/pnas.0609009103

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Huse, M., Lillemeier, B.F., Kuhns, M.S., Chen, D.S., Davis, M.M. T cells use two directionally distinct pathways for cytokine secretion. (2006) Nature Immunology. 7(3):247-55. DOI: 10.1038/ni1304

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Kerr, I.M., Costa-Pereira, A.P., Lillemeier, B.F., Strobl, B. Of JAKs, STATs, blind watchmakers, jeeps and trains. (2003) FEBS Letters. 546(1):1-5.

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Hilkens, C.M., Is'harc, H., Lillemeier, B.F., Strobl, B., Bates, P.A., Behrmann, I., Kerr, I.M. A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130. (2001) FEBS Lett. 505(1):87-91.

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van Ham, M., van Lith, M., Lillemeier, B., Tjin, E., Grüneberg, U., Rahman, D., Pastoors, L., van Meijgaarden, K., Roucard, C., Trowsdale, J., Ottenhoff, T., Pappin, D., Neefjes, J. Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO. (2000) Journal of Experimental Medicine. 191(7):1127-36.

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van Ham, S.M., Tjin, E.P., Lillemeier, B.F., Grüneberg, U., van Meijgaarden, K.E., Pastoors, L., Verwoerd, D., Tulp, A., Canas, B., Rahman, D., Ottenhoff, T.H., Pappin, D.J., Trowsdale, J., Neefjes, J. HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading. (1997) Current Biology. 7(12):950-7.

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Education

Undergraduate degree in Biochemistry, Free University Berlin (Germany) and Cancer Research UK (formerly Imperial Cancer Research Fund, U.K.)
PhD, Biochemistry, Cancer Research UK (formerly Imperial Cancer Research Fund) and University College London (U.K.)
Postdoctoral Fellow, Stanford University (U.S.A.)


Awards & Honors

  • 2013 Helen McLoraine Developmental Chair
  • 2012 NIH Director's New Innovator Award
  • 2010 Rudolph and Sletten Developmental Chair
  • 2002 Human Frontier Science Program Fellowship
  • 1997 Böhringer Ingelheim Fonds Scholarship
  • 1996 Dr. Carl Duisberg Stiftung Scholarship