Vicki Lundblad

Professor

Molecular and Cell Biology Laboratory

Becky and Ralph S. O'Connor Chair

Salk Institute for Biological Studies - Publications

all Publications


Thomas, S.T., Louie, G.V., Lubin, J.W., Lundblad, V., Noel, J.P. Substrate Specificity and Engineering of Mevalonate 5-Phosphate Decarboxylase. (2019) ACS Chemical Biology. 14(8):1767-1779. DOI: 10.1021/acschembio.9b00322

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Paul Solomon Devakumar, L.J., Gaubitz, C., Lundblad, V., Kelch, B.A., Kubota, T. Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex. (2019) Nucleic Acids Research. 47(13):6826-6841. DOI: 10.1093/nar/gkz441

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Glustrom, L.W., Lyon, K.R., Paschini, M., Reyes, C.M., Parsonnet, N.V., Toro, T.B., Lundblad, V., Wuttke, D.S. Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function. (2018) Proceedings of the National Academy of Sciences of the United States of America. 115(41):10315-10320. DOI: 10.1073/pnas.1722147115

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Lubin, J.W., Tucey, T.M., Lundblad, V. Using Separation-of-Function Mutagenesis To Define the Full Spectrum of Activities Performed by the Est1 Telomerase Subunit in Vivo. (2017) Genetics. 208(1):97-110. DOI: 10.1534/genetics.117.300145

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Tucey, T.M., Lundblad, V. Regulated assembly and disassembly of the yeast telomerase quaternary complex. (2014) Genes & Development. 28(19):2077-89. DOI: 10.1101/gad.246256.114

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Rao, T., Lubin, J.W., Armstrong, G.S., Tucey, T.M., Lundblad, V., Wuttke, D.S. Structure of Est3 reveals a bimodal surface with differential roles in telomere replication. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(1):214-8. DOI: 10.1073/pnas.1316453111

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Ballew, B.J., Lundblad, V. Multiple genetic pathways regulate replicative senescence in telomerase-deficient yeast. (2013) Aging Cell. 12(4):719-27. DOI: 10.1111/acel.12099

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Lubin, J.W., Rao, T., Mandell, E.K., Wuttke, D.S., Lundblad, V. Dissecting protein function: an efficient protocol for identifying separation-of-function mutations that encode structurally stable proteins. (2013) Genetics. 193(3):715-25. DOI: 10.1534/genetics.112.147801

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Tucey, T.M., Lundblad, V. A yeast telomerase complex containing the Est1 recruitment protein is assembled early in the cell cycle. (2013) Biochemistry. 52(7):1131-3. DOI: 10.1021/bi3015218

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Lubin, J.W., Tucey, T.M., Lundblad, V. The interaction between the yeast telomerase RNA and the Est1 protein requires three structural elements. (2012) RNA. 18(9):1597-604. DOI: 10.1261/rna.034447.112

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Lundblad, V. Telomere end processing: unexpected complexity at the end game. (2012) Genes & Development. 26(11):1123-7. DOI: 10.1101/gad.195339.112

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Paschini, M., Toro, T.B., Lubin, J.W., Braunstein-Ballew, B., Morris, D.K., Lundblad, V. A naturally thermolabile activity compromises genetic analysis of telomere function in Saccharomyces cerevisiae. (2012) Genetics. 191(1):79-93. DOI: 10.1534/genetics.111.137869

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Mandell, E.K., Gelinas, A.D., Wuttke, D.S., Lundblad, V. Sequence-specific binding to telomeric DNA is not a conserved property of the Cdc13 DNA binding domain. (2011) Biochemistry. 50(29):6289-91. DOI: 10.1021/bi2005448

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Gao, H., Toro, T.B., Paschini, M., Braunstein-Ballew, B., Cervantes, R.B., Lundblad, V. Telomerase recruitment in Saccharomyces cerevisiae is not dependent on Tel1-mediated phosphorylation of Cdc13. (2010) Genetics. 186(4):1147-59. DOI: 10.1534/genetics.110.122044

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Paschini, M., Mandell, E.K., Lundblad, V. Structure prediction-driven genetics in Saccharomyces cerevisiae identifies an interface between the t-RPA proteins Stn1 and Ten1. (2010) Genetics. 185(1):11-21. DOI: 10.1534/genetics.109.111922

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Lee, J., Mandell, E.K., Rao, T., Wuttke, D.S., Lundblad, V. Investigating the role of the Est3 protein in yeast telomere replication. (2010) Nucleic Acids Research. 38(7):2279-90. DOI: 10.1093/nar/gkp1173

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Gelinas, A.D., Paschini, M., Reyes, F.E., Héroux, A., Batey, R.T., Lundblad, V., Wuttke, D.S. Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain. (2009) Proceedings of the National Academy of Sciences of the United States of America. 106(46):19298-303. DOI: 10.1073/pnas.0909203106

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Lee, J., Mandell, E.K., Tucey, T.M., Morris, D.K., Lundblad, V. The Est3 protein associates with yeast telomerase through an OB-fold domain. (2008) Nature Structural & Molecular Biology. 15(9):990-7.

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Gao, H., Cervantes, R.B., Mandell, E.K., Otero, J.H., Lundblad, V. RPA-like proteins mediate yeast telomere function. (2007) Nature Structural & Molecular Biology. 14(3):208-14. DOI: 10.1038/nsmb1205

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Lundblad, V. Telomeres in the '80s: a few recollections. (2006) Nature Structural & Molecular Biology. 13(12):1036-8. DOI: 10.1038/nsmb1206-1036

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Bertuch, A.A., Lundblad, V. The maintenance and masking of chromosome termini. (2006) Current Opinion in Cell Biology. 18(3):247-53. DOI: 10.1016/j.ceb.2006.04.005

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Baumgartner, B.L., Lundblad, V. Telomere identity crisis. (2005) Genes & Development. 19(21):2522-5. DOI: 10.1101/gad.1373205


Chappell, A.S., Lundblad, V. Structural elements required for association of the Saccharomyces cerevisiae telomerase RNA with the Est2 reverse transcriptase. (2004) Molecular and Cellular Biology. 24(17):7720-36. DOI: 10.1128/MCB.24.17.7720-7736.2004

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Bertuch, A.A., Lundblad, V. EXO1 contributes to telomere maintenance in both telomerase-proficient and telomerase-deficient Saccharomyces cerevisiae. (2004) Genetics. 166(4):1651-9.

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Bertuch, A.A., Lundblad, V. The Ku heterodimer performs separable activities at double-strand breaks and chromosome termini. (2003) Molecular and Cellular Biology. 23(22):8202-15.

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Bertuch, A.A., Lundblad, V. Which end: dissecting Ku's function at telomeres and double-strand breaks. (2003) Genes & Development. 17(19):2347-50. DOI: 10.1101/gad.1146603


Theobald, D.L., Cervantes, R.B., Lundblad, V., Wuttke, D.S. Homology among telomeric end-protection proteins. (2003) Structure. 11(9):1049-50.

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Lowell, J.E., Roughton, A.I., Lundblad, V., Pillus, L. Telomerase-independent proliferation is influenced by cell type in Saccharomyces cerevisiae. (2003) Genetics. 164(3):909-21.

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Lundblad, V. Telomeres: taking the measure. (2003) Nature. 423(6943):926-7. DOI: 10.1038/423926a


Bertuch, A.A., Buckley, K., Lundblad, V. The way to the end matters--the role of telomerase in tumor progression. (2003) Cell Cycle. 2(1):36-8. DOI: 10.4161/cc.2.1.278


Lundblad, V. Telomere replication: an Est fest. (2003) Current Biology. 13(11):R439-41.

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Evans, S.K., Lundblad, V. The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance. (2002) Genetics. 162(3):1101-15.

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Cervantes, R.B., Lundblad, V. Mechanisms of chromosome-end protection. (2002) Current Opinion in Cell Biology. 14(3):351-6.

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Mitton-Fry, R.M., Anderson, E.M., Hughes, T.R., Lundblad, V., Wuttke, D.S. Conserved structure for single-stranded telomeric DNA recognition. (2002) Science. 296(5565):145-7. DOI: 10.1126/science.1068799

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Lundblad, V. Telomere maintenance without telomerase. (2002) Oncogene. 21(4):522-31. DOI: 10.1038/sj.onc.1205079

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Lundblad, V. Genome instability: McClintock revisited. (2001) Current Biology. 11(23):R957-60.

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Rizki, A., Lundblad, V. Defects in mismatch repair promote telomerase-independent proliferation. (2001) Nature. 411(6838):713-6. DOI: 10.1038/35079641

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Hanna, J.S., Kroll, E.S., Lundblad, V., Spencer, F.A. Saccharomyces cerevisiae CTF18 and CTF4 are required for sister chromatid cohesion. (2001) Molecular and Cellular Biology. 21(9):3144-58. DOI: 10.1128/MCB.21.9.3144-3158.2001

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Pennock, E., Buckley, K., Lundblad, V. Cdc13 delivers separate complexes to the telomere for end protection and replication. (2001) Cell. 104(3):387-96. DOI: 10.1016/s0092-8674(01)00226-4

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Chandra, A., Hughes, T.R., Nugent, C.I., Lundblad, V. Cdc13 both positively and negatively regulates telomere replication. (2001) Genes & Development. 15(4):404-14. DOI: 10.1101/gad.861001

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Evans, S.K., Lundblad, V. Positive and negative regulation of telomerase access to the telomere. (2000) Journal of Cell Science. 113 Pt 19:3357-64.

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Hughes, T.R., Evans, S.K., Weilbaecher, R.G., Lundblad, V. The Est3 protein is a subunit of yeast telomerase. (2000) Current Biology. 10(13):809-12.

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Lundblad, V. DNA ends: maintenance of chromosome termini versus repair of double strand breaks. (2000) Mutation Research. 451(1-2):227-40.

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Lundblad, V. Molecular biology. Telomeres keep on rappin'. (2000) Science. 288(5474):2141-2.

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Hughes, T.R., Weilbaecher, R.G., Walterscheid, M., Lundblad, V. Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein. (2000) Proceedings of the National Academy of Sciences of the United States of America. 97(12):6457-62.

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Lundblad, V. Telomeres: a tale of ends. (2000) Nature. 403(6766):149, 151. DOI: 10.1038/35003085


Weilbaecher, R.G., Lundblad, V. Assembly and regulation of telomerase. (1999) Current Opinion in Chemical Biology. 3(5):573-7.

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Zumstein, L.A., Lundblad, V. Telomeres: has cancer's Achilles' heel been exposed? (1999) Nature Medicine. 5(10):1129-30. DOI: 10.1038/13451


Evans, S.K., Lundblad, V. Est1 and Cdc13 as comediators of telomerase access. (1999) Science. 286(5437):117-20.

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Evans, S.K., Bertuch, A.A., Lundblad, V. Telomeres and telomerase: at the end, it all comes together. (1999) Trends in Cell Biology. 9(8):329-31.


Weinert, T., Lundblad, V. Forever hopeful relations: chromatin, telomeres and checkpoints. (1999) Nature Genetics. 21(2):151-2. DOI: 10.1038/5930


Evans, S.K., Sistrunk, M.L., Nugent, C.I., Lundblad, V. Telomerase, Ku, and telomeric silencing in Saccharomyces cerevisiae. (1998) Chromosoma. 107(6-7):352-8.

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Bertuch, A., Lundblad, V. Telomeres and double-strand breaks: trying to make ends meet. (1998) Trends in Cell Biology. 8(9):339-42.

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Lundblad, V. Telomerase catalysis: a phylogenetically conserved reverse transcriptase. (1998) Proceedings of the National Academy of Sciences of the United States of America. 95(15):8415-6.


Nugent, C.I., Bosco, G., Ross, L.O., Evans, S.K., Salinger, A.P., Moore, J.K., Haber, J.E., Lundblad, V. Telomere maintenance is dependent on activities required for end repair of double-strand breaks. (1998) Current Biology. 8(11):657-60.

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Nugent, C.I., Lundblad, V. The telomerase reverse transcriptase: components and regulation. (1998) Genes & Development. 12(8):1073-85.


Morris, D.K., Lundblad, V. Programmed translational frameshifting in a gene required for yeast telomere replication. (1997) Current Biology. 7(12):969-76.

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Lundblad, V. The end replication problem: more than one solution. (1997) Nature Medicine. 3(11):1198-9.


Lingner, J., Cech, T.R., Hughes, T.R., Lundblad, V. Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. (1997) Proceedings of the National Academy of Sciences of the United States of America. 94(21):11190-5.

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Hughes, T.R., Morris, D.K., Salinger, A., Walcott, N., Nugent, C.I., Lundblad, V. The role of the EST genes in yeast telomere replication. (1997) Ciba Foundation Symposium. 211:41-7; discussion 47-52, 71-5.

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Lingner, J., Hughes, T.R., Shevchenko, A., Mann, M., Lundblad, V., Cech, T.R. Reverse transcriptase motifs in the catalytic subunit of telomerase. (1997) Science. 276(5312):561-7.

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Lendvay, T.S., Morris, D.K., Sah, J., Balasubramanian, B., Lundblad, V. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. (1996) Genetics. 144(4):1399-412.

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Virta-Pearlman, V., Morris, D.K., Lundblad, V. Est1 has the properties of a single-stranded telomere end-binding protein. (1996) Genes & Development. 10(24):3094-104. DOI: 10.1101/gad.10.24.3094

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Lundblad, V., Wright, W.E. Telomeres and telomerase: a simple picture becomes complex. (1996) Cell. 87(3):369-75. DOI: 10.1016/s0092-8674(00)81358-6


Nugent, C.I., Hughes, T.R., Lue, N.F., Lundblad, V. Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. (1996) Science. 274(5285):249-52.

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Lundblad, V., Blackburn, E.H. An alternative pathway for yeast telomere maintenance rescues est1- senescence. (1993) Cell. 73(2):347-60.

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Lundblad, V., Blackburn, E.H. RNA-dependent polymerase motifs in EST1: tentative identification of a protein component of an essential yeast telomerase. (1990) Cell. 60(4):529-30.


Lundblad, V., Szostak, J.W. A mutant with a defect in telomere elongation leads to senescence in yeast. (1989) Cell. 57(4):633-43.

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Lundblad, V., Kleckner, N. Mismatch repair mutations of Escherichia coli K12 enhance transposon excision. (1985) Genetics. 109(1):3-19.

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Lundblad, V., Taylor, A.F., Smith, G.R., Kleckner, N. Unusual alleles of recB and recC stimulate excision of inverted repeat transposons Tn10 and Tn5. (1984) Proceedings of the National Academy of Sciences of the United States of America. 81(3):824-8.

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Lundblad, V., Kleckner, N. Mutants of Escherichia coli K12 which affect excision of transposon Tn10. (1982) Basic Life Sci. 20:245-58.

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Foster, T.J., Lundblad, V., Hanley-Way, S., Halling, S.M., Kleckner, N. Three Tn10-associated excision events: relationship to transposition and role of direct and inverted repeats. (1981) Cell. 23(1):215-27.

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Kleckner, N., Foster, T.J., Davis, M.A., Hanley-Way, S., Halling, S.M., Lundblad, V., Takeshita, K. Genetic organization of Tn10 and analysis of Tn10-associated excision events. (1981) Cold Spring Harbor Symposia on Quantitative Biology. 45 Pt 1:225-38.


Wiche, G., Lundblad, V.J., Cole, R.D. Competence of soluble cell extracts as microtubule assembly systems. Comparison of simian virus 40 transformed and nontransformed mouse 3T3 fibroblasts. (1977) Journal of Biological Chemistry. 252(2):794-6.

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Education

BS, University of California, Berkeley
PhD, Harvard University
Postdoctoral Fellow, Harvard Medical School and UC Berkeley


Awards & Honors

  • 2015 National Academy of Sciences
  • 2014 Fellow of the American Academy for Microbiology
  • 2008 Pearl Meister Greengard Prize
  • 2003 Fellow of the American Association for the Advancement of Science
  • 2002 NIH MERIT award, National Institute on Aging
  • 2002 AACR-NFCR Professorship in Basic Cancer Research
  • 2001 Ellison Medical Foundation Senior Scholar in Aging Award
  • 1997 Michael E. DeBakey, M.D. Excellence in Research Award
  • 1994 American Cancer Society Junior Faculty Award