Vicki Lundblad


Molecular and Cell Biology Laboratory

Becky and Ralph S. O'Connor Chair

Salk Institute for Biological Studies - Publications


Glustrom, L.W., Lyon, K., Paschini, M., Reyes, C.M., Parsonett, N.B., Toro, T.B., Lundblad, V. and Wuttke, D.S. (2018). Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function. PNAS, in press.

Lubin, J.W., Tucey, T.M. and Lundblad, V. (2018). Using separation-of-function mutagenesis to define the full spectrum of activities performed by the Est1 telomerase subunit in vivo. Genetics 208, 97-110.

Rao, T., Lubin, J., Armstrong, G.S., Tucey T.M., Lundblad, V. and Wuttke, D.S. (2014). Structure of Est3 reveals a bimodal surface with differential roles in telomere replication. PNAS, 111, 214-218.

Tucey T.M. and Lundblad, V. (2014). Regulated assembly and disassembly of the yeast telomerase complex. Genes & Dev. 28, 2077–2089.

Ballew, B.J. and Lundblad, V. (2013) Multiple genetic pathways regulate replicative senescence in telomerase-deficient yeast. Aging Cell, 12, 719-727.

Lubin, J., Rao, T., Mandell, E.K., Wuttke, D.S. and Lundblad, V. (2013) Dissecting protein function: an efficient protocol for identifying separation-of-function mutations that encode structurally stable proteins. Genetics, 193, 715-725.

Tucey T.M. and Lundblad, V. (2013). A yeast telomerase complex containing the Est1 recruitment protein is assembled early in the cell cycle. Biochemistry, 52, 1131-1133.

Lubin, J.W., Tucey, T.M. and Lundblad, V. (2012). The interaction between the yeast telomerase RNA and the Est1 protein requires three structural elements. RNA, 18, 1597-604.

Paschini, M., Toro, T.B, Lubin, J.W., Braunstein-Ballew, B., Morris, D.K. and Lundblad, V. (2012). A naturally thermolabile activity compromises genetic analysis of telomere function in Saccharomyces cerevisiae. Genetics, 191, 79-93.

Mandell, E.K., Gelinas, A.D., Wuttke, D.S. and Lundblad, V. (2011). Sequence-specific binding to telomeric DNA is not a conserved property of the Cdc13 DNA binding domain. Biochemistry, 50, 6289-6291.

Paschini, M., Mandell, E.K. and Lundblad, V. (2010). Structure prediction-driven genetics in Saccharomyces cerevisiae identifies an interface between the t-RPA proteins Stn1 and Ten1. Genetics, 185, 11-21.

Lee, J.S., Mandell, E.K., Rao, T., Wuttke, D.S. and Lundblad, V. (2010). Investigating the role of the Est3 protein in yeast telomere replication. Nucleic Acids Res., 38, 2279-2290.

Gao, H., Toro, T.B., Paschini, M., Braunstein-Ballew, B., Cervantes, R.B. and Lundblad, V. (2010). Telomerase recruitment in Saccharomyces cerevisiae is not dependent on Tel1-mediated phosphorylation of Cdc13. Genetics 186, 1147-1159.

Gelinas, A.D., Paschini, M., Reyes, F.E., Héroux, A., Batey, R.T., Lundblad, V., and Wuttke, D.S. (2009). The telomere capping proteins Stn1 and Ten1 are structurally related to RPA32 and RPA14. PNAS 106, 19298-19303.

Lee, J.S., Mandell, E.K., Tucey T.M. Morris, D.K. and Lundblad, V. (2008). The Est3 protein associates with yeast telomerase through an OB-fold domain. Nature Struct. & Mol. Biol. 15, 990-997.

Gao, H., Cervantes, R.B., Mandell, E.K., Otero, J., and Lundblad, V. (2007). RPA-like proteins mediate yeast telomere function. Nature Struct. & Mol. Biol. 14, 208-214.


BS, University of California, Berkeley
PhD, Harvard University
Postdoctoral Fellow, Harvard Medical School and UC Berkeley

Awards & Honors

  • 2015 National Academy of Sciences
  • 2014 Fellow of the American Academy for Microbiology
  • 2008 Pearl Meister Greengard Prize
  • 2003 Fellow of the American Association for the Advancement of Science
  • 2002 NIH MERIT award, National Institute on Aging
  • 2002 AACR-NFCR Professorship in Basic Cancer Research
  • 2001 Ellison Medical Foundation Senior Scholar in Aging Award
  • 1997 Michael E. DeBakey, M.D. Excellence in Research Award
  • 1994 American Cancer Society Junior Faculty Award