Tony Hunter

American Cancer Society Professor

Molecular and Cell Biology Laboratory

Renato Dulbecco Chair

Tony Hunter
Salk Institute for Biological Studies - Publications


Shi Y., Gao W., Lytle N.K., Huang P., Yuan X., Dann A.M., Ridinger M., DelGiorno K.E., Antal C.E., Liang G., Atkins A.R., Erikson G., Sun H., Meisenhelder J., Terenziani E., Woo G., Fang L., Santisakultarm T.P., Manor U., Xu R., Becerra C.R., Borazanci E., Von Hoff D.D., Grandgenett P.M., Hollingsworth M.A., Leblanc M., Umetsu S.E., Collisson E.A., Scadeng M., Lowy A.M., Donahue T.R., Reya T., Downes M.,Evans R.M. , Wahl G.M., Pawson T., Tian R. and Hunter T. (2019). Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature 2019;DOI: 10.1038/s41586-019-1130-6

Wang Z., Wu C., Aslanian A., Yates III J.R., Hunter T. (2018). Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway. eLife 2018;7:e35447

Zhu Q., Hoong N., Aslanian A., Hara T., Benner C., Heinz S., Miga K.H., Ke E., Verma S., Soroczynski J., Yates III J.R., Hunter T., Verma I.M. (2018). Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer. Mol Cell 70:842-853

Hindupur S.K., Colombi M, Fuhs S.R., Matter M.S., Guri Y., Adam K., Cornu M, Piscuoglio S., Ng C.K.Y., Betz C., Liko D., Quagliata L., Moes S., Jenoe P., Terracciano L.M., Heim M.H., Hunter T. and Hall M.N. (2018). The protein histidine phosphatase LHPP is a tumour suppressor. Nature 555, 678–682. 29 March 2018.

Zheng, X., and Hunter, T. (2014). Pink1, the first ubiquitin kinase. EMBO J.

Voog, J., Sandall, S. L., Hime, G. R., Resende, L. P. F., Loza-Coll, M., Aslanian, A., Yates II, J. R., Hunter, T., Fuller, M. T., and Jones, D. L. 2014. Escargot restricts niche cell to stem cell conversion in the Drosophila testis. Cell Rep. 7: 722-74.

Zheng, X., and Hunter, T. (2014). Pink1, the first ubiquitin kinase. EMBO J.

Voog, J., Sandall, S. L., Hime, G. R., Resende, L. P. F., Loza-Coll, M., Aslanian, A., Yates II, J. R., Hunter, T., Fuller, M. T., and Jones, D. L. 2014. Escargot restricts niche cell to stem cell conversion in the Drosophila testis. Cell Rep. 7: 722-74.

Ma, H., Han, B.K., Guaderrama, M., Aslanian, A., Yates, J.R., 3rd, Hunter, T., and Wittenberg, C. (2014). Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression. Mol Cell Biol 34:452-463.

Carrano AC, Dillin A and Hunter T. 2014. A Krüppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans. Nat Commun. May 8;5:3772. doi: 10.1038/ncomms4772.

Hunter T. 2014. The genesis of tyrosine phosphorylation. Cold Spring Harb Perspect Biol. May 1;6(5). pii: a020644. doi: 10.1101/cshperspect.a020644.

Ma L, Aslanian A, Sun H, Jin M, Shi Y, Yates JR 3rd and Hunter T. 2014. Identification of SUMO Substrates with Diverse Functions Using the Xenopus Egg Extract System. Mol Cell Proteomics. 2014 May 5.

Aslanian A, Yates JR 3rd and Hunter T. 2014. Mass spectrometry-based quantification of the cellular response to methyl methanesulfonate treatment in human cells. DNA Repair (Amst). 2014 Mar;15:29-38. doi: 10.1016/j.dnarep.2013.12.007. Epub 2014 Jan 22.

Zhang Y and Hunter T. 2014. Roles of Chk1 in cell biology and cancer therapy. Int J Cancer. 2014 Mar 1;134(5):1013-23. doi: 10.1002/ijc.28226. Epub 2013 May 28. Review.

Zheng X and Hunter T. 2013. Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism. Cell Res. 2013 Jul;23(7):886-97. doi: 10.1038/cr.2013.66. Epub 2013 May 14.

Yang,W., Xia, Y. Hawke, D., Li, X., Liang, J., Aldape, K., Hunter, T., Yung, W.K.A., and Lu, Z.. 2012. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150:685-696.

Zhang, Q.C., Petrey, D., Deng, L., Qiang. L., Shi, Y., Thu, C. A., Bisikirska, B., Lefebvre, C., Accili, D., Hunter, T., Maniatis, T. Califano, A., and Honig, B. 2012. Structure-based prediction of protein-protein interactions on a genome-wide scale. Nature 490:556-560.

Sun H and Hunter T. 2012. Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search. J Biol Chem. 2012 Dec 7;287(50):42071-83. doi: 10.1074/jbc.M112.410985. Epub 2012 Oct 18.

Zhu W, Kuo D, Nathanson J, Satoh A, Pao GM, Yeo GW, Bryant SV, Voss SR, Gardiner DM and Hunter T. 2012. Retrotransposon long interspersed nucleotide element-1 (LINE-1) is activated during salamander limb regeneration. Dev Growth Differ. 2012 Sep;54(7):673-85. doi: 10.1111/j.1440-169X.2012.01368.x. Epub 2012 Aug 23.

Hunter, T. (2012). Why nature chose phosphate to modify proteins. Philos Trans R Soc Lond B Biol Sci 367:2513-2516.

Wang Z, Shah OJ and Hunter T. 2012. The transcriptional coactivators p/CIP and SRC-1 control insulin resistance through IRS1 in obesity models. PLoS One. 2012;7(7):e36961. doi: 10.1371/journal.pone.0036961. Epub 2012 Jul 31.

Zhu, W., Pao, G.M., Satoh, A., Cummings, G., Monaghan, J.R., Harkins, T.T., Bryant, S.V., Randal Voss, S., Gardiner, D.M., and Hunter, T. (2012). Activation of germline-specific genes is required for limb regeneration in the Mexican axolotl. Dev Biol 370:42-51.

Visit the Hunter lab website to view additional publications.


BA, First Class Honors, University of Cambridge, England
PhD, University of Cambridge, England
Postdoctoral Fellow, The Salk Institute and University of Cambridge

Awards & Honors

  • 2018 Tang Prize in Biopharmaceutical Science
  • 2018 Pezcoller–AACR International Award for Extraordinary Achievement in Cancer Research
  • 2017 Sjöberg Prize for Cancer Research
  • 2014 Royal Medal in Biological Sciences
  • 2013 Fellow, AACR Academy
  • 2013 Einstein Professor, Chinese Academy of Sciences
  • 2012 Thomson-Reuters Citation Laureate
  • 2011 Signal Transduction Society Honorary Medal
  • 2011 Lifetime Achievement in Cancer Research Award, Jefferson Kimmel Cancer Center
  • 2007 Clifford Prize for Cancer Research
  • 2006 Robert J. and Claire Pasarow award for Cancer Research
  • 2006 Daniel Nathan's Memorial Award
  • 2005 Wolf Prize in Medicine
  • 2004 Louisa Gross Horwitz Prize
  • 2004 Prince of Asturias Award for Scientific and Technical Research
  • 2004 Kirk A. Landon-AACR Prize for Basic Cancer Research
  • 2004 American Cancer Society Medal of Honor
  • 2003 City of Medicine Award
  • 2003 Sergio Lombroso Award in Cancer Research
  • 2001 Keio Medical Science Prize
  • 2000 J. Allyn Taylor International Prize in Medicine
  • 1994 Gairdner Foundation International Award
  • 1994 General Motors Cancer Research Foundation Prize
  • American Cancer Society Research Professorship
  • Member of the American Philosophical Society
  • Member of the National Academy of Medicine
  • Fellow of the American Academy of Arts and Sciences
  • Member of the United States National Academy of Sciences
  • Fellow of the Royal Society of London