Tony Hunter

American Cancer Society Professor

Molecular and Cell Biology Laboratory

Renato Dulbecco Chair

Tony Hunter
Salk Institute for Biological Studies - Publications

all Publications


Adam, K., Hunter, T. Subcellular Localization of Histidine Phosphorylated Proteins Through Indirect Immunofluorescence. (2020) Methods in Molecular Biology. 2077:209-224. DOI: 10.1007/978-1-4939-9884-5_14

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Luhtala, N., Hunter, T. Immunohistochemistry (IHC): Chromogenic Detection of 3-Phosphohistidine Proteins in Formaldehyde-Fixed, Frozen Mouse Liver Tissue Sections. (2020) Methods in Molecular Biology. 2077:193-208. DOI: 10.1007/978-1-4939-9884-5_13

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Kalagiri, R., Adam, K., Hunter, T. Empirical Evidence of Cellular Histidine Phosphorylation by Immunoblotting Using pHis mAbs. (2020) Methods in Molecular Biology. 2077:Methods in Molecular Biology. DOI: 10.1007/978-1-4939-9884-5_12

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Shi, Y., Hunter, S., Hunter, T. Stem Cell Factor LIFted as a Promising Clinical Target for Cancer Therapy. (2019) Molecular Cancer Therapeutics. 18(8):1337-1340. DOI: 10.1158/1535-7163.MCT-19-0605


Neftel, C., Laffy, J., Filbin, M.G., Hara, T., Shore, M.E., Rahme, G.J., Richman, A.R., Silverbush, D., Shaw, M.L., Hebert, C.M., Dewitt, J., Gritsch, S., Perez, E.M., Gonzalez Castro, L.N., Lan, X., Druck, N., Rodman, C., Dionne, D., Kaplan, A., Bertalan, M.S., Small, J., Pelton, K., Becker, S., Bonal, D., Nguyen, Q.D., Servis, R.L., Fung, J.M., Mylvaganam, R., Mayr, L., Gojo, J., Haberler, C., Geyeregger, R., Czech, T., Slavc, I., Nahed, B.V., Curry, W.T., Carter, B.S., Wakimoto, H., Brastianos, P.K., Batchelor, T.T., Stemmer-Rachamimov, A., Martinez-Lage, M., Frosch, M.P., Stamenkovic, I., Riggi, N., Rheinbay, E., Monje, M., Rozenblatt-Rosen, O., Cahill, D.P., Patel, A.P., Hunter, T., Verma, I.M., Ligon, K.L., Louis, D.N., Regev, A., Bernstein, B.E., Tirosh, I., Suvà, M.L. An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma. (2019) Cell. 178(4):835-849. DOI: 10.1016/j.cell.2019.06.024

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Shi, Y., Gao, W., Lytle, N.K., Huang, P., Yuan, X., Dann, A.M., Ridinger-Saison, M., DelGiorno, K.E., Antal, C.E., Liang, G., Atkins, A.R., Erikson, G., Sun, H., Meisenhelder, J., Terenziani, E., Woo, G., Fang, L., Santisakultarm, T.P., Manor, U., Xu, R., Becerra, C.R., Borazanci, E., Von Hoff, D.D., Grandgenett, P.M., Hollingsworth, M.A., Leblanc, M., Umetsu, S.E., Collisson, E.A., Scadeng, M., Lowy, A.M., Donahue, T.R., Reya, T., Downes, M., Evans, R.M., Wahl, G.M., Pawson, T., Tian, R., Hunter, T. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. (2019) Nature. 569(7754):131-135. DOI: 10.1038/s41586-019-1130-6

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Bonanomi, D., Valenza, F., Chivatakarn, O., Sternfeld, M.J., Driscoll, S.P., Aslanian, A., Lettieri, K., Gullo, M., Badaloni, A., Lewcock, J.W., Hunter, T., Pfaff, S.L. p190RhoGAP Filters Competing Signals to Resolve Axon Guidance Conflicts. (2019) Neuron. DOI: 10.1016/j.neuron.2019.02.034

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Lamarche, B.J., Orazio, N.I., Goben, B., Meisenhelder, J., You, Z., Weitzman, M.D., Hunter, T. Repair of protein-linked DNA double strand breaks: Using the adenovirus genome as a model substrate in cell-based assays. (2018) DNA Repair (Amst.). DOI: 10.1016/j.dnarep.2018.12.001

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Chou, A.C., Aslanian, A., Sun, H., Hunter, T. An internal ribosome entry site in the coding region of tyrosyl-DNA phosphodiesterase 2 drives alternative translation start. (2018) Journal of Biological Chemistry. DOI: 10.1074/jbc.RA118.006269

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Luhtala, N., Hunter, T. Failure to detect functional transfer of active K-Ras protein from extracellular vesicles into recipient cells in culture. (2018) PLOS One. 13(9):e0203290. DOI: 10.1371/journal.pone.0203290

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Wang, Z., Wu, C., Aslanian, A., Yates, J.R., Hunter, T. Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway. (2018) Elife. 7. DOI: 10.7554/eLife.35447

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Chu, B., He, A., Tian, Y., He, W., Chen, P., Hu, J., Xu, R., Zhou, W., Zhang, M., Yang, P., Li, S.S.C., Sun, Y., Li, P., Hunter, T., Tian, R. Photoaffinity-engineered protein scaffold for systematically exploring native phosphotyrosine signaling complexes in tumor samples. (2018) Proceedings of the National Academy of Sciences of the United States of America. 115(38)::E8863-E8872. DOI: 10.1073/pnas.1805633115

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Kim, Y., Zheng, X., Ansari, Z., Bunnell, M.C., Herdy, J.R., Traxler, L., Lee, H., Paquola, A.C.M., Blithikioti, C., Ku, M., Schlachetzki, J.C.M., Winkler, J., Edenhofer, F., Glass, C.K., Paucar, A.A., Jaeger, B.N., Pham, S., Boyer, L., Campbell, B.C., Hunter, T., Mertens, J., Gage, F.H. Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile. (2018) Cell Reports. 23(9):2550-2558. DOI: 10.1016/j.celrep.2018.04.105

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Zhu, Q., Hoong, N., Aslanian, A., Hara, T., Benner, C., Heinz, S., Miga, K.H., Ke, E., Verma, S., Soroczynski, J., Yates, J.R., Hunter, T., Verma, I.M. Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer. (2018) Molecular Cell. DOI: 10.1016/j.molcel.2018.04.023

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Hsu, C.L., Lee, E.X., Gordon, K.L., Paz, E.A., Shen, W.C., Ohnishi, K., Meisenhelder, J., Hunter, T., La Spada, A.R. MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. (2018) Nature Communications. 9(1):942. DOI: 10.1038/s41467-018-03340-7

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Hindupur, S.K., Colombi, M., Fuhs, S.R., Matter, M.S., Guri, Y., Adam, K., Cornu, M., Piscuoglio, S., Ng, C.K.Y., Betz, C., Liko, D., Quagliata, L., Moes, S., Jenoe, P., Terracciano, L.M., Heim, M.H., Hunter, T., Hall, M.N. The protein histidine phosphatase LHPP is a tumour suppressor. (2018) Nature. 555(7698):678-682. DOI: 10.1038/nature26140

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Settleman, J., Sawyers, C.L., Hunter, T. Challenges in validating candidate therapeutic targets in cancer. (2018) Elife. 7. DOI: 10.7554/eLife.32402

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Lu, Z., Hunter, T. Metabolic Kinases Moonlighting as Protein Kinases. (2018) Trends in Biochemical Sciences. 43(4):301-310. DOI: 10.1016/j.tibs.2018.01.006

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Adam, K., Hunter, T. Histidine kinases and the missing phosphoproteome from prokaryotes to eukaryotes. (2017) Lab. Invest. 98(2):233-247. DOI: 10.1038/labinvest.2017.118

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Paudyal, S.C., Li, S., Yan, H., Hunter, T., You, Z. Dna2 initiates resection at clean DNA double-strand breaks. (2017) Nucleic Acids Research. 45(20):11766-11781. DOI: 10.1093/nar/gkx830

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Hoppmann, C., Wong, A., Yang, B., Li, S., Hunter, T., Shokat, K.M., Wang, L. Site-specific incorporation of phosphotyrosine using an expanded genetic code. (2017) Nature Chemical Biology. 13(8):842-844. DOI: 10.1038/nchembio.2406

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French, M.E., Klosowiak, J.L., Aslanian, A., Reed, S.I., Yates, J.R., Hunter, T. Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase. (2017) Journal of Biological Chemistry. 292(25):10398-10413. DOI: 10.1074/jbc.M117.789479

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Fuhs, S.R., Hunter, T. pHisphorylation: the emergence of histidine phosphorylation as a reversible regulatory modification. (2017) Current Opinion in Cell Biology. 45:8-16. DOI: 10.1016/j.ceb.2016.12.010

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Luhtala, N., Aslanian, A., Yates, J.R., Hunter, T. Secreted Glioblastoma Nanovesicles Contain Intracellular Signaling Proteins and Active Ras Incorporated in a Farnesylation-dependent Manner. (2017) Journal of Biological Chemistry. 292(2):611-628. DOI: 10.1074/jbc.M116.747618

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Srivastava, S., Panda, S., Li, Z., Fuhs, S.R., Hunter, T., Thiele, D.J., Hubbard, S.R., Skolnik, E.Y. Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1. (2016) Elife. 5. DOI: 10.7554/eLife.16093

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Panda, S., Srivastava, S., Li, Z., Vaeth, M., Fuhs, S.R., Hunter, T., Skolnik, E.Y. Identification of PGAM5 as a Mammalian Protein Histidine Phosphatase that Plays a Central Role to Negatively Regulate CD4(+) T Cells. (2016) Molecular Cell. 63(3):457-69. DOI: 10.1016/j.molcel.2016.06.021

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Zheng, X., Boyer, L., Jin, M., Mertens, J., Kim, Y., Ma, L., Ma, L., Hamm, M., Gage, F.H., Hunter, T. Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation. (2016) Elife. 5. DOI: 10.7554/eLife.13374

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Zheng, X., Boyer, L., Jin, M., Kim, Y., Fan, W., Bardy, C., Berggren, T., Evans, R.M., Gage, F.H., Hunter, T. Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration. (2016) Elife. 5. DOI: 10.7554/eLife.13378

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Li, X., Jiang, Y., Meisenhelder, J., Yang, W., Hawke, D.H., Zheng, Y., Xia, Y., Aldape, K., He, J., Hunter, T., Wang, L., Lu, Z. Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis. (2016) Molecular Cell. 61(5):705-719. DOI: 10.1016/j.molcel.2016.02.009

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Marusiak, A.A., Stephenson, N.L., Baik, H., Trotter, E.W., Li, Y., Blyth, K., Mason, S., Chapman, P., Puto, L.A., Read, J.A., Brassington, C., Pollard, H.K., Phillips, C., Green, I., Overman, R., Collier, M., Testoni, E., Miller, C.J., Hunter, T., Sansom, O.J., Brognard, J. Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis. (2016) Cancer Research. 76(3):724-35. DOI: 10.1158/0008-5472.CAN-15-0701-T

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Heimbucher, T., Hunter, T. The C. elegans Ortholog of USP7 controls DAF-16 stability in Insulin/IGF-1-like signaling. (2015) Worm. 4(4):e1103429. DOI: 10.1080/21624054.2015.1103429

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Denli, A.M., Narvaiza, I., Kerman, B.E., Pena, M., Benner, C., Marchetto, M.C., Diedrich, J.K., Aslanian, A., Ma, J., Moresco, J.J., Moore, L., Hunter, T., Saghatelian, A., Gage, F.H. Primate-specific ORF0 contributes to retrotransposon-mediated diversity. (2015) Cell. 163(3):583-93. DOI: 10.1016/j.cell.2015.09.025

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Zheng, X., Hunter, T. How phosphoubiquitin activates Parkin. (2015) Cell Research. 25(10):1087-8. DOI: 10.1038/cr.2015.97

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Carrano, A.C., Hunter, T. Fitting WWP-1 in the dietary restriction network. (2015) Cell Cycle. 14(10):1485-6. DOI: 10.1080/15384101.2015.1032642


Heimbucher, T., Liu, Z., Bossard, C., McCloskey, R., Carrano, A.C., Riedel, C.G., Tanasa, B., Klammt, C., Fonslow, B.R., Riera, C.E., Lillemeier, B.F., Kemphues, K., Yates, J.R., O, C., Hunter, T., Dillin, A. The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity. (2015) Cell Metabolism. 22(1):151-63. DOI: 10.1016/j.cmet.2015.06.002

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Fuhs, S.R., Meisenhelder, J., Aslanian, A., Ma, L., Zagorska, A., Stankova, M., Binnie, A., Al-Obeidi, F., Mauger, J., Lemke, G., Yates, J.R., Hunter, T. Monoclonal 1- and 3-Phosphohistidine Antibodies: New Tools to Study Histidine Phosphorylation. (2015) Cell. 162(1):198-210. DOI: 10.1016/j.cell.2015.05.046

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Hunter, T. Discovering the first tyrosine kinase. (2015) Proceedings of the National Academy of Sciences of the United States of America. 112(26):7877-82. DOI: 10.1073/pnas.1508223112

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Puto, L.A., Brognard, J., Hunter, T. Transcriptional Repressor DAXX Promotes Prostate Cancer Tumorigenicity via Suppression of Autophagy. (2015) Journal of Biological Chemistry. 290(25):15406-20. DOI: 10.1074/jbc.M115.658765

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Puto, L.A., Benner, C., Hunter, T. The DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer. (2015) Oncoscience. 2(4):362-72. DOI: 10.18632/oncoscience.152

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Tian, R., Wang, H., Gish, G.D., Petsalaki, E., Pasculescu, A., Shi, Y., Mollenauer, M., Bagshaw, R.D., Yosef, N., Hunter, T., Gingras, A.C., Weiss, A., Pawson, T. Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor. (2015) Proceedings of the National Academy of Sciences of the United States of America. 112(13):E1594-603. DOI: 10.1073/pnas.1503286112

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Antal, C.E., Hudson, A.M., Kang, E., Zanca, C., Wirth, C., Stephenson, N.L., Trotter, E.W., Gallegos, L.L., Miller, C.J., Furnari, F.B., Hunter, T., Brognard, J., Newton, A.C. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. (2015) Cell. 160(3):489-502. DOI: 10.1016/j.cell.2015.01.001

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Wilkinson, D.S., Jariwala, J.S., Anderson, E., Mitra, K., Meisenhelder, J., Chang, J.T., Ideker, T., Hunter, T., Nizet, V., Dillin, A., Hansen, M. Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy. (2015) Molecular Cell. 57(1):55-68. DOI: 10.1016/j.molcel.2014.11.019

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Basnet, H., Su, X.B., Tan, Y., Meisenhelder, J., Merkurjev, D., Ohgi, K.A., Hunter, T., Pillus, L., Rosenfeld, M.G. Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation. (2014) Nature. 516(7530):267-71. DOI: 10.1038/nature13736

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Thorner, J., Hunter, T., Cantley, L.C., Sever, R. Signal transduction: From the atomic age to the post-genomic era. (2014) Cold Spring Harbor Perspectives in Biology. 6(12):a022913. DOI: 10.1101/cshperspect.a022913

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Sherman, M.H., Yu, R.T., Engle, D.D., Ding, N., Atkins, A.R., Tiriac, H., Collisson, E.A., Connor, F., Van Dyke, T., Kozlov, S., Martin, P., Tseng, T.W., Dawson, D.W., Donahue, T.R., Masamune, A., Shimosegawa, T., Apte, M.V., Wilson, J.S., Ng, B., Lau, S.L., Gunton, J.E., Wahl, G.M., Hunter, T., Drebin, J.A., O'Dwyer, P.J., Liddle, C., Tuveson, D.A., Downes, M., Evans, R.M. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. (2014) Cell. 159(1):80-93. DOI: 10.1016/j.cell.2014.08.007

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Lu, Z., Hunter, T. Prolyl isomerase Pin1 in cancer. (2014) Cell Research. 24(9):1033-49. DOI: 10.1038/cr.2014.109

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Zheng, X., Hunter, T. Pink1, the first ubiquitin kinase. (2014) EMBO Journal. 33(15):1621-3. DOI: 10.15252/embj.201489185


Sun, H., Liu, Y., Hunter, T. Multiple Arkadia/RNF111 structures coordinate its Polycomb body association and transcriptional control. (2014) Molecular and Cellular Biology. 34(16):2981-95. DOI: 10.1128/MCB.00036-14

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Yang, W., Xia, Y., Hawke, D., Li, X., Liang, J., Xing, D., Aldape, K., Hunter, T., Yung, W.K.A., Lu, Z. PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis. (2014) Cell. 158(5):1210. DOI: 10.1016/j.cell.2014.08.003


Ma, L., Aslanian, A., Sun, H., Jin, M., Shi, Y., Yates, J.R., Hunter, T. Identification of small ubiquitin-like modifier substrates with diverse functions using the Xenopus egg extract system. (2014) Molecular & Cellular Proteomics. 13(7):1659-75. DOI: 10.1074/mcp.M113.035626

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Carrano, A.C., Dillin, A., Hunter, T. A Krüppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans. (2014) Nature Communications. 5:3772. DOI: 10.1038/ncomms4772

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Voog, J., Sandall, S.L., Hime, G.R., Resende, L.P., Loza-Coll, M., Aslanian, A., Yates, J.R., Hunter, T., Fuller, M.T., Jones, D.L. Escargot restricts niche cell to stem cell conversion in the Drosophila testis. (2014) Cell Reports. 7(3):722-34. DOI: 10.1016/j.celrep.2014.04.025

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Hunter, T. The genesis of tyrosine phosphorylation. (2014) Cold Spring Harbor Perspectives in Biology. 6(5):a020644. DOI: 10.1101/cshperspect.a020644

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Aslanian, A., Yates, J.R., Hunter, T. Mass spectrometry-based quantification of the cellular response to methyl methanesulfonate treatment in human cells. (2014) DNA Repair. 15:29-38. DOI: 10.1016/j.dnarep.2013.12.007

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Zhang, Y., Hunter, T. Roles of Chk1 in cell biology and cancer therapy. (2014) International Journal of Cancer. 134(5):1013-23. DOI: 10.1002/ijc.28226

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Ma, H., Han, B.K., Guaderrama, M., Aslanian, A., Yates, J.R., Hunter, T., Wittenberg, C. Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression. (2014) Molecular and Cellular Biology. 34(3):452-63. DOI: 10.1128/MCB.00279-13

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Hunter, T. Retrospective. Tony Pawson (1952-2013). (2013) Science. 341(6150):1078. DOI: 10.1126/science.1244986


Zheng, X., Hunter, T. Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism. (2013) Cell Research. 23(7):886-97. DOI: 10.1038/cr.2013.66

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Hunter, T. Translating experience: thinking outside the box. (2013) Nature Cell Biology. 15(6):545. DOI: 10.1038/ncb2771


Sun, H., Hunter, T. Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search. (2012) Journal of Biological Chemistry. 287(50):42071-83. DOI: 10.1074/jbc.M112.410985

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Lu, C.S., Truong, L.N., Aslanian, A., Shi, L.Z., Li, Y., Hwang, P.Y., Koh, K.H., Hunter, T., Yates, J.R., Berns, M.W., Wu, X. The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination. (2012) Journal of Biological Chemistry. 287(52):43984-94. DOI: 10.1074/jbc.M112.421545

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Zhu, W., Pao, G.M., Satoh, A., Cummings, G., Monaghan, J.R., Harkins, T.T., Bryant, S.V., Randal Voss, S., Gardiner, D.M., Hunter, T. Activation of germline-specific genes is required for limb regeneration in the Mexican axolotl. (2012) Developmental Biology. 370(1):42-51. DOI: 10.1016/j.ydbio.2012.07.021

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Zhang, Q.C., Petrey, D., Deng, L., Qiang, L., Shi, Y., Thu, C.A., Bisikirska, B., Lefebvre, C., Accili, D., Hunter, T., Maniatis, T., Califano, A., Honig, B. Structure-based prediction of protein-protein interactions on a genome-wide scale. (2012) Nature. 490(7421):556-60. DOI: 10.1038/nature11503

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Zhu, W., Kuo, D., Nathanson, J., Satoh, A., Pao, G.M., Yeo, G.W., Bryant, S.V., Voss, S.R., Gardiner, D.M., Hunter, T. Retrotransposon long interspersed nucleotide element-1 (LINE-1) is activated during salamander limb regeneration. (2012) Dev. Growth Differ. 54(7):673-85. DOI: 10.1111/j.1440-169X.2012.01368.x

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Hunter, T. Why nature chose phosphate to modify proteins. (2012) Philos. Trans. R. Soc. Lond., B, Biol. Sci. 367(1602):2513-6. DOI: 10.1098/rstb.2012.0013

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Hunter, T., Pawson, T. The evolution of protein phosphorylation. Preface. (2012) Philos. Trans. R. Soc. Lond., B, Biol. Sci. 367(1602):2512. DOI: 10.1098/rstb.2012.0374


Yang, W., Xia, Y., Hawke, D., Li, X., Liang, J., Xing, D., Aldape, K., Hunter, T., Alfred Yung, W.K., Lu, Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. (2012) Cell. 150(4):685-96. DOI: 10.1016/j.cell.2012.07.018

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Wang, Z., Shah, O.J., Hunter, T. The transcriptional coactivators p/CIP and SRC-1 control insulin resistance through IRS1 in obesity models. (2012) PLOS One. 7(7):e36961. DOI: 10.1371/journal.pone.0036961

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Chaurushiya, M.S., Lilley, C.E., Aslanian, A., Meisenhelder, J., Scott, D.C., Landry, S., Ticau, S., Boutell, C., Yates, J.R., Schulman, B.A., Hunter, T., Weitzman, M.D. Viral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark targets the RNF8 FHA domain. (2012) Molecular Cell. 46(1):79-90. DOI: 10.1016/j.molcel.2012.02.004

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Brognard, J., Zhang, Y.W., Puto, L.A., Hunter, T. Cancer-associated loss-of-function mutations implicate DAPK3 as a tumor-suppressing kinase. (2011) Cancer Research. 71(8):3152-61. DOI: 10.1158/0008-5472.CAN-10-3543

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Brognard, J., Hunter, T. Protein kinase signaling networks in cancer. (2011) Current Opinion in Genetics & Development. 21(1):4-11. DOI: 10.1016/j.gde.2010.10.012

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Olson, B.J., Oberholzer, M., Li, Y., Zones, J.M., Kohli, H.S., Bisova, K., Fang, S.C., Meisenhelder, J., Hunter, T., Umen, J.G. Regulation of the Chlamydomonas cell cycle by a stable, chromatin-associated retinoblastoma tumor suppressor complex. (2010) Plant Cell. 22(10):3331-47. DOI: 10.1105/tpc.110.076067

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Yoon, Y.S., Lee, M.W., Ryu, D., Kim, J.H., Ma, H., Seo, W.Y., Kim, Y.N., Kim, S.S., Lee, C.H., Hunter, T., Choi, C.S., Montminy, M.R., Koo, S.H. Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(41):17704-9. DOI: 10.1073/pnas.1012665107

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Liew, C.W., Sun, H., Hunter, T., Day, C.L. RING domain dimerization is essential for RNF4 function. (2010) Biochemical Journal. 431(1):23-9. DOI: 10.1042/BJ20100957

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Lu, Z., Hunter, T. Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors. (2010) Cell Cycle. 9(12):2342-52. DOI: 10.4161/cc.9.12.11988

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López-Otín, C., Hunter, T. The regulatory crosstalk between kinases and proteases in cancer. (2010) Nature Reviews. Cancer. 10(4):278-92. DOI: 10.1038/nrc2823

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Hunter, T., Marais, R. Genetic and cellular mechanisms of oncogenesis. (2010) Current Opinion in Genetics & Development. 20(1):1-3. DOI: 10.1016/j.gde.2010.01.001


You, Z., Shi, L.Z., Zhu, Q., Wu, P., Zhang, Y.W., Basilio, A., Tonnu, N., Verma, I.M., Berns, M.W., Hunter, T. CtIP links DNA double-strand break sensing to resection. (2009) Molecular Cell. 36(6):954-69. DOI: 10.1016/j.molcel.2009.12.002

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Malumbres, M., Harlow, E., Hunt, T., Hunter, T., Lahti, J.M., Manning, G., Morgan, D.O., Tsai, L.H., Wolgemuth, D.J. Cyclin-dependent kinases: a family portrait. (2009) Nature Cell Biology. 11(11):1275-6. DOI: 10.1038/ncb1109-1275


Zhang, Y.W., Brognard, J., Coughlin, C., You, Z., Dolled-Filhart, M., Aslanian, A., Manning, G., Abraham, R.T., Hunter, T. The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. (2009) Molecular Cell. 35(4):442-53. DOI: 10.1016/j.molcel.2009.06.030

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Carrano, A.C., Liu, Z., Dillin, A., Hunter, T. A conserved ubiquitination pathway determines longevity in response to diet restriction. (2009) Nature. 460(7253):396-9. DOI: 10.1038/nature08130

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Lu, Z., Hunter, T. Degradation of activated protein kinases by ubiquitination. (2009) Annual Review of Biochemistry. 78:435-75. DOI: 10.1146/annurev.biochem.013008.092711

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Pearson, G.W., Hunter, T. PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture. (2009) Breast Cancer Research. 11(3):R29. DOI: 10.1186/bcr2259

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Hunter, T. Tyrosine phosphorylation: thirty years and counting. (2009) Current Opinion in Cell Biology. 21(2):140-6. DOI: 10.1016/j.ceb.2009.01.028

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Copp, J., Manning, G., Hunter, T. TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. (2009) Cancer Research. 69(5):1821-7. DOI: 10.1158/0008-5472.CAN-08-3014

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Smith, J.J., Putta, S., Zhu, W., Pao, G.M., Verma, I.M., Hunter, T., Bryant, S.V., Gardiner, D.M., Harkins, T.T., Voss, S.R. Genic regions of a large salamander genome contain long introns and novel genes. (2009) BMC Genomics. 10:19. DOI: 10.1186/1471-2164-10-19

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Monaghan, J.R., Epp, L.G., Putta, S., Page, R.B., Walker, J.A., Beachy, C.K., Zhu, W., Pao, G.M., Verma, I.M., Hunter, T., Bryant, S.V., Gardiner, D.M., Harkins, T.T., Voss, S.R. Microarray and cDNA sequence analysis of transcription during nerve-dependent limb regeneration. (2009) BMC Biology. 7:1. DOI: 10.1186/1741-7007-7-1

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Hunter, T., Sun, H. Crosstalk between the SUMO and ubiquitin pathways. (2008) Ernst Schering Found Symp Proc.(1):1-16

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Hashimoto, T., Yamauchi, L., Hunter, T., Kikkawa, U., Kamada, S. Possible involvement of caspase-7 in cell cycle progression at mitosis. (2008) Genes to Cells. 13(6):609-21. DOI: 10.1111/j.1365-2443.2008.01192.x

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Hunter, T. Tony Hunter: kinase king. Interview by Ruth Williams. (2008) Journal of Cell Biology. 181(4):572-3. DOI: 10.1083/jcb.1814pi


Bailis, J.M., Luche, D.D., Hunter, T., Forsburg, S.L. Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote s-phase genome stability. (2008) Molecular and Cellular Biology. 28(5):1724-38. DOI: 10.1128/MCB.01717-07

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Ghosh, S., Marquardt, T., Thaler, J.P., Carter, N., Andrews, S.E., Pfaff, S.L., Hunter, T. Instructive role of aPKCzeta subcellular localization in the assembly of adherens junctions in neural progenitors. (2008) Proceedings of the National Academy of Sciences of the United States of America. 105(1):335-40. DOI: 10.1073/pnas.0705713105

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Pearson, G.W., Hunter, T. Real-time imaging reveals that noninvasive mammary epithelial acini can contain motile cells. (2007) Journal of Cell Biology. 179(7):1555-67. DOI: 10.1083/jcb.200706099

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Hunter, T. The age of crosstalk: phosphorylation, ubiquitination, and beyond. (2007) Molecular Cell. 28(5):730-8. DOI: 10.1016/j.molcel.2007.11.019

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You, Z., Bailis, J.M., Johnson, S.A., Dilworth, S.M., Hunter, T. Rapid activation of ATM on DNA flanking double-strand breaks. (2007) Nature Cell Biology. 9(11):1311-8. DOI: 10.1038/ncb1651

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Sun, H., Leverson, J.D., Hunter, T. Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins. (2007) EMBO Journal. 26(18):4102-12. DOI: 10.1038/sj.emboj.7601839

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Johnson, S.A., You, Z., Hunter, T. Monitoring ATM kinase activity in living cells. (2007) DNA Repair. 6(9):1277-84. DOI: 10.1016/j.dnarep.2007.02.025

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Hunter, T. Treatment for chronic myelogenous leukemia: the long road to imatinib. (2007) Journal of Clinical Investigation. 117(8):2036-43. DOI: 10.1172/JCI31691

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Zhang, Y., Daum, S., Wildemann, D., Zhou, X.Z., Verdecia, M.A., Bowman, M.E., Lücke, C., Hunter, T., Lu, K.P., Fischer, G., Noel, J.P. Structural basis for high-affinity peptide inhibition of human Pin1. (2007) ACS Chemical Biology. 2(5):320-8. DOI: 10.1021/cb7000044

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Fang, D., Hawke, D., Zheng, Y., Xia, Y., Meisenhelder, J., Nika, H., Mills, G.B., Kobayashi, R., Hunter, T., Lu, Z. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. (2007) Journal of Biological Chemistry. 282(15):11221-9. DOI: 10.1074/jbc.M611871200

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Hunter, T., Simon, J. A not so brief history of the Oncogene Meeting and its cartoons. (2007) Oncogene. 26(9):1260-7. DOI: 10.1038/sj.onc.1210262


Bozulic, L., Morin, P., Hunter, T., Hemmings, B.A. Meeting report: targeting the kinome--20 years of tyrosine kinase inhibitor research in Basel. (2007) Sci. STKE. 2007(374):pe8. DOI: 10.1126/stke.3742007pe8

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Xia, Y., Wang, J., Liu, T.J., Yung, W.K., Hunter, T., Lu, Z. c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis. (2007) Molecular Cell. 25(2):219-32. DOI: 10.1016/j.molcel.2007.01.005

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Xia, Y., Wang, J., Xu, S., Johnson, G.L., Hunter, T., Lu, Z. MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress. (2007) Molecular and Cellular Biology. 27(2):510-7. DOI: 10.1128/MCB.01355-06

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Ghosh, S., Tergaonkar, V., Rothlin, C.V., Correa, R.G., Bottero, V., Bist, P., Verma, I.M., Hunter, T. Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. (2006) Cancer Cell. 10(3):215-26. DOI: 10.1016/j.ccr.2006.08.007

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Shah, O.J., Hunter, T. Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis. (2006) Molecular and Cellular Biology. 26(17):6425-34. DOI: 10.1128/MCB.01254-05

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Joazeiro, C.A., Anderson, K.C., Hunter, T. Proteasome inhibitor drugs on the rise. (2006) Cancer Research. 66(16):7840-2. DOI: 10.1158/0008-5472.CAN-06-2033

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Wolff, S., Ma, H., Burch, D., Maciel, G.A., Hunter, T., Dillin, A. SMK-1, an essential regulator of DAF-16-mediated longevity. (2006) Cell. 124(5):1039-53. DOI: 10.1016/j.cell.2005.12.042

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Petersen, P., Chou, D.M., You, Z., Hunter, T., Walter, J.C., Walter, G. Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. (2006) Molecular and Cellular Biology. 26(5):1997-2011. DOI: 10.1128/MCB.26.5.1997-2011.2006

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Wang, Z., Qi, C., Krones, A., Woodring, P., Zhu, X., Reddy, J.K., Evans, R.M., Rosenfeld, M.G., Hunter, T. Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance. (2006) Cell Metabolism. 3(2):111-22. DOI: 10.1016/j.cmet.2006.01.002

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Zhang, Y.W., Hunter, T., Abraham, R.T. Turning the replication checkpoint on and off. (2006) Cell Cycle. 5(2):125-8. DOI: 10.4161/cc.5.2.2308

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Hunter, T., Schulman, H. CaMKII structure--an elegant design. (2005) Cell. 123(5):765-7. DOI: 10.1016/j.cell.2005.11.017

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Kamada, S., Kikkawa, U., Tsujimoto, Y., Hunter, T. A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association. (2005) Molecular and Cellular Biology. 25(21):9469-77. DOI: 10.1128/MCB.25.21.9469-9477.2005

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Huang, H.K., Bailis, J.M., Leverson, J.D., Gómez, E.B., Forsburg, S.L., Hunter, T. Suppressors of Bir1p (Survivin) identify roles for the chromosomal passenger protein Pic1p (INCENP) and the replication initiation factor Psf2p in chromosome segregation. (2005) Molecular and Cellular Biology. 25(20):9000-15. DOI: 10.1128/MCB.25.20.9000-9015.2005

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Watanabe, N., Arai, H., Iwasaki, J., Shiina, M., Ogata, K., Hunter, T., Osada, H. Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways. (2005) Proceedings of the National Academy of Sciences of the United States of America. 102(33):11663-8. DOI: 10.1073/pnas.0500410102

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You, Z., Chahwan, C., Bailis, J., Hunter, T., Russell, P. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. (2005) Molecular and Cellular Biology. 25(13):5363-79. DOI: 10.1128/MCB.25.13.5363-5379.2005

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Wang, X., Li, X., Meisenhelder, J., Hunter, T., Yoshida, S., Asami, T., Chory, J. Autoregulation and homodimerization are involved in the activation of the plant steroid receptor BRI1. (2005) Developmental Cell. 8(6):855-65. DOI: 10.1016/j.devcel.2005.05.001

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Marquardt, T., Shirasaki, R., Ghosh, S., Andrews, S.E., Carter, N., Hunter, T., Pfaff, S.L. Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains. (2005) Cell. 121(1):127-39. DOI: 10.1016/j.cell.2005.01.020

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Takagi, Y., Masuda, C.A., Chang, W.H., Komori, H., Wang, D., Hunter, T., Joazeiro, C.A., Kornberg, R.D. Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage. (2005) Molecular Cell. 18(2):237-43. DOI: 10.1016/j.molcel.2005.03.007

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Woodring, P.J., Hunter, T., Wang, J.Y. Mitotic phosphorylation rescues Abl from F-actin-mediated inhibition. (2005) Journal of Biological Chemistry. 280(11):10318-25. DOI: 10.1074/jbc.M410658200

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Papin, J.A., Hunter, T., Palsson, B.O., Subramaniam, S. Reconstruction of cellular signalling networks and analysis of their properties. (2005) Nature Reviews. Molecular Cell Biology. 6(2):99-111. DOI: 10.1038/nrm1570

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Johnson, S.A., Hunter, T. Kinomics: methods for deciphering the kinome. (2005) Nature Methods. 2(1):17-25. DOI: 10.1038/nmeth731

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Shah, O.J., Hunter, T. Tuberous sclerosis and insulin resistance. Unlikely bedfellows reveal a TORrid affair. (2005) Cell Cycle. 4(1):46-51. DOI: 10.4161/cc.4.1.1343

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Kamada, S., Kikkawa, U., Tsujimoto, Y., Hunter, T. Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s). (2005) Journal of Biological Chemistry. 280(2):857-60. DOI: 10.1074/jbc.C400538200

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York, J.D., Hunter, T. Signal transduction. Unexpected mediators of protein phosphorylation. (2004) Science. 306(5704):2053-5. DOI: 10.1126/science.1107225


Grabbe, C., Zervas, C.G., Hunter, T., Brown, N.H., Palmer, R.H. Focal adhesion kinase is not required for integrin function or viability in Drosophila. (2004) Development. 131(23):5795-805. DOI: 10.1242/dev.01462

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Shah, O.J., Wang, Z., Hunter, T. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. (2004) Current Biology. 14(18):1650-6. DOI: 10.1016/j.cub.2004.08.026

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Johnson, S.A., Hunter, T. Phosphoproteomics finds its timing. (2004) Nature Biotechnology. 22(9):1093-4. DOI: 10.1038/nbt0904-1093


Caenepeel, S., Charydczak, G., Sudarsanam, S., Hunter, T., Manning, G. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. (2004) Proceedings of the National Academy of Sciences of the United States of America. 101(32):11707-12. DOI: 10.1073/pnas.0306880101

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Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J., Mustelin, T. Protein tyrosine phosphatases in the human genome. (2004) Cell. 117(6):699-711. DOI: 10.1016/j.cell.2004.05.018

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Fukunaga, R., Hunter, T. Identification of MAPK substrates by expression screening with solid-phase phosphorylation. (2004) Methods in Molecular Biology. 250:211-36. DOI: 10.1385/1-59259-671-1:211


Woodring, P.J., Meisenhelder, J., Johnson, S.A., Zhou, G.L., Field, J., Shah, K., Bladt, F., Pawson, T., Niki, M., Pandolfi, P.P., Wang, J.Y., Hunter, T. c-Abl phosphorylates Dok1 to promote filopodia during cell spreading. (2004) Journal of Cell Biology. 165(4):493-503. DOI: 10.1083/jcb.200312171

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Shah, O.J., Hunter, T. Critical role of T-loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the tuberous sclerosis complex. (2004) Journal of Biological Chemistry. 279(20):20816-23. DOI: 10.1074/jbc.M400957200

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Lu, Z., Hunter, T. Wnt-independent beta-catenin transactivation in tumor development. (2004) Cell Cycle. 3(5):571-3.

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Watanabe, N., Arai, H., Nishihara, Y., Taniguchi, M., Watanabe, N., Hunter, T., Osada, H. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. (2004) Proceedings of the National Academy of Sciences of the United States of America. 101(13):4419-24. DOI: 10.1073/pnas.0307700101

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Hunter, T., Eckhart, W. The discovery of tyrosine phosphorylation: it's all in the buffer! (2004) Cell. 116(2 Suppl):S35-9, 1 p following S48.


Lu, Z., Ghosh, S., Wang, Z., Hunter, T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. (2003) Cancer Cell. 4(6):499-515.

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Lorén, C.E., Englund, C., Grabbe, C., Hallberg, B., Hunter, T., Palmer, R.H. A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster. (2003) EMBO Reports. 4(8):781-6. DOI: 10.1038/sj.embor.embor897

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Sonnenburg, E.D., Bilwes, A., Hunter, T., Noel, J.P. The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region. (2003) Biochemistry. 42(26):7904-14. DOI: 10.1021/bi0340503

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Woodring, P.J., Hunter, T., Wang, J.Y. Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases. (2003) Journal of Cell Science. 116(Pt 13):2613-26. DOI: 10.1242/jcs.00622

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Liou, Y.C., Sun, A., Ryo, A., Zhou, X.Z., Yu, Z.X., Huang, H.K., Uchida, T., Bronson, R., Bing, G., Li, X., Hunter, T., Lu, K.P. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. (2003) Nature. 424(6948):556-61. DOI: 10.1038/nature01832

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Shah, O.J., Ghosh, S., Hunter, T. Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and non-consensus sites by Cdc2. (2003) Journal of Biological Chemistry. 278(18):16433-42. DOI: 10.1074/jbc.M300435200

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O'Connell, M.J., Krien, M.J., Hunter, T. Never say never. The NIMA-related protein kinases in mitotic control. (2003) Trends in Cell Biology. 13(5):221-8.

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Xia, Y., Pao, G.M., Chen, H.W., Verma, I.M., Hunter, T. Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. (2003) Journal of Biological Chemistry. 278(7):5255-63. DOI: 10.1074/jbc.M204591200

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Verdecia, M.A., Joazeiro, C.A., Wells, N.J., Ferrer, J.L., Bowman, M.E., Hunter, T., Noel, J.P. Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. (2003) Molecular Cell. 11(1):249-59.

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Uchida, T., Takamiya, M., Takahashi, M., Miyashita, H., Ikeda, H., Terada, T., Matsuo, Y., Shirouzu, M., Yokoyama, S., Fujimori, F., Hunter, T. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. (2003) Chemistry & Biology. 10(1):15-24.

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Gilman, A.G., Simon, M.I., Bourne, H.R., Harris, B.A., Long, R., Ross, E.M., Stull, J.T., Taussig, R., Bourne, H.R., Arkin, A.P., Cobb, M.H., Cyster, J.G., Devreotes, P.N., Ferrell, J.E., Fruman, D., Gold, M., Weiss, A., Stull, J.T., Berridge, M.J., Cantley, L.C., Catterall, W.A., Coughlin, S.R., Olson, E.N., Smith, T.F., Brugge, J.S., Botstein, D., Dixon, J.E., Hunter, T., Lefkowitz, R.J., Pawson, A.J., Sternberg, P.W., Varmus, H., Subramaniam, S., Sinkovits, R.S., Li, J., Mock, D., Ning, Y., Saunders, B., Sternweis, P.C., Hilgemann, D., Scheuermann, R.H., DeCamp, D., Hsueh, R., Lin, K.M., Ni, Y., Seaman, W.E., Simpson, P.C., O'Connell, T.D., Roach, T., Simon, M.I., Choi, S., Eversole-Cire, P., Fraser, I., Mumby, M.C., Zhao, Y., Brekken, D., Shu, H., Meyer, T., Chandy, G., Heo, W.D., Liou, J., O'Rourke, N., Verghese, M., Mumby, S.M., Han, H., Brown, H.A., Forrester, J.S., Ivanova, P., Milne, S.B., Casey, P.J., Harden, T.K., Arkin, A.P., Doyle, J., Gray, M.L., Meyer, T., Michnick, S., Schmidt, M.A., Toner, M., Tsien, R.Y., Natarajan, M., Ranganathan, R., Sambrano, G.R. Overview of the Alliance for Cellular Signaling. (2002) Nature. 420(6916):703-6. DOI: 10.1038/nature01304

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Manning, G., Whyte, D.B., Martinez, R., Hunter, T., Sudarsanam, S. The protein kinase complement of the human genome. (2002) Science. 298(5600):1912-34. DOI: 10.1126/science.1075762

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Manning, G., Plowman, G.D., Hunter, T., Sudarsanam, S. Evolution of protein kinase signaling from yeast to man. (2002) Trends in Biochemical Sciences. 27(10):514-20.

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Carter, N., Nakamoto, T., Hirai, H., Hunter, T. EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas). (2002) Nature Cell Biology. 4(8):565-73. DOI: 10.1038/ncb823

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Hunter, T. Tyrosine phosphorylation in cell signaling and disease. (2002) Keio J Med. 51(2):61-71.


Mollinari, C., Kleman, J.P., Jiang, W., Schoehn, G., Hunter, T., Margolis, R.L. PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone. (2002) Journal of Cell Biology. 157(7):1175-86. DOI: 10.1083/jcb.200111052

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Lu, Z., Xu, S., Joazeiro, C., Cobb, M.H., Hunter, T. The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. (2002) Molecular Cell. 9(5):945-56.

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Asahara, H., Tartare-Deckert, S., Nakagawa, T., Ikehara, T., Hirose, F., Hunter, T., Ito, T., Montminy, M. Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. (2002) Molecular and Cellular Biology. 22(9):2974-83.

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Leverson, J.D., Huang, H.K., Forsburg, S.L., Hunter, T. The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis. (2002) Molecular Biology of the Cell. 13(4):1132-43. DOI: 10.1091/mbc.01-07-0330

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Woodring, P.J., Litwack, E.D., O'Leary, D.D., Lucero, G.R., Wang, J.Y., Hunter, T. Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. (2002) Journal of Cell Biology. 156(5):879-92. DOI: 10.1083/jcb.200110014

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Fang, D., Elly, C., Gao, B., Fang, N., Altman, Y., Joazeiro, C., Hunter, T., Copeland, N., Jenkins, N., Liu, Y.C. Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. (2002) Nature Immunology. 3(3):281-7. DOI: 10.1038/ni763

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Liou, Y.C., Ryo, A., Huang, H.K., Lu, P.J., Bronson, R., Fujimori, F., Uchida, T., Hunter, T., Lu, K.P. Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. (2002) Proceedings of the National Academy of Sciences of the United States of America. 99(3):1335-40. DOI: 10.1073/pnas.032404099

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Mustelin, T., Hunter, T. Meeting at mitosis: cell cycle-specific regulation of c-Src by RPTPalpha. (2002) Sci. STKE. 2002(115):pe3. DOI: 10.1126/stke.2002.115.pe3

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Buck, M., Zhang, L., Halasz, N.A., Hunter, T., Chojkier, M. Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha. (2001) EMBO Journal. 20(23):6712-23. DOI: 10.1093/emboj/20.23.6712

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Huang, H.K., Forsburg, S.L., John, U.P., O'Connell, M.J., Hunter, T. Isolation and characterization of the Pin1/Ess1p homologue in Schizosaccharomyces pombe. (2001) Journal of Cell Science. 114(Pt 20):3779-88.

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Buck, M., Poli, V., Hunter, T., Chojkier, M. C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival. (2001) Molecular Cell. 8(4):807-16.

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Woodring, P.J., Hunter, T., Wang, J.Y. Inhibition of c-Abl tyrosine kinase activity by filamentous actin. (2001) Journal of Biological Chemistry. 276(29):27104-10. DOI: 10.1074/jbc.M100559200

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Lu, Z., Jiang, G., Blume-Jensen, P., Hunter, T. Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. (2001) Molecular and Cellular Biology. 21(12):4016-31. DOI: 10.1128/MCB.21.12.4016-4031.2001

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Lorén, C.E., Scully, A., Grabbe, C., Edeen, P.T., Thomas, J., McKeown, M., Hunter, T., Palmer, R.H. Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo. (2001) Genes to Cells. 6(6):531-44.

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Tertoolen, L.G., Blanchetot, C., Jiang, G., Overvoorde, J., Gadella, T.W., Hunter, T., den Hertog, J. Dimerization of receptor protein-tyrosine phosphatase alpha in living cells. (2001) BMC Cell Biology. 2:8.

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Meisenhelder, J., Hunter, T., van der Geer, P. Phosphopeptide mapping and identification of phosphorylation sites. (2001) Current Protocols in Protein Science. Chapter 13:Unit13.9. DOI: 10.1002/0471140864.ps1309s18

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Meisenhelder, J., Hunter, T., van der Geer, P. Phosphopeptide mapping and identification of phosphorylation sites. (2001) Current Protocols in Molecular Biology. Chapter 18:Unit 18.9. DOI: 10.1002/0471142727.mb1809s48

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Blume-Jensen, P., Hunter, T. Oncogenic kinase signalling. (2001) Nature. 411(6835):355-65. DOI: 10.1038/35077225

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Hauck, C.R., Hunter, T., Schlaepfer, D.D. The v-Src SH3 domain facilitates a cell adhesion-independent association with focal adhesion kinase. (2001) Journal of Biological Chemistry. 276(21):17653-62. DOI: 10.1074/jbc.M009329200

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Ruffner, H., Joazeiro, C.A., Hemmati, D., Hunter, T., Verma, I.M. Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity. (2001) Proceedings of the National Academy of Sciences of the United States of America. 98(9):5134-9. DOI: 10.1073/pnas.081068398

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Blume-Jensen, P., Hunter, T. Two-dimensional phosphoamino acid analysis. (2001) Methods in Molecular Biology. 124:49-65.


Moniakis, J., Funamoto, S., Fukuzawa, M., Meisenhelder, J., Araki, T., Abe, T., Meili, R., Hunter, T., Williams, J., Firtel, R.A. An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway. (2001) Genes & Development. 15(6):687-98. DOI: 10.1101/gad.871001

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Potter, L.R., Hunter, T. Activation of protein kinase C stimulates the dephosphorylation of natriuretic peptide receptor-B at a single serine residue: a possible mechanism of heterologous desensitization. (2000) Journal of Biological Chemistry. 275(40):31099-106. DOI: 10.1074/jbc.M005506200

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Joazeiro, C.A., Hunter, T. Biochemistry. Ubiquitination--more than two to tango. (2000) Science. 289(5487):2061-2.

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Huang, H.k., Joazeiro, C.A., Bonfoco, E., Kamada, S., Leverson, J.D., Hunter, T. The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7. (2000) Journal of Biological Chemistry. 275(35):26661-4. DOI: 10.1074/jbc.C000199200

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Friedrichsen, D.M., Joazeiro, C.A., Li, J., Hunter, T., Chory, J. Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase. (2000) Plant Physiology. 123(4):1247-56.

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Jiang, G., den Hertog, J., Hunter, T. Receptor-like protein tyrosine phosphatase alpha homodimerizes on the cell surface. (2000) Molecular and Cellular Biology. 20(16):5917-29.

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Verdecia, M.A., Bowman, M.E., Lu, K.P., Hunter, T., Noel, J.P. Structural basis for phosphoserine-proline recognition by group IV WW domains. (2000) Nature Structural Biology. 7(8):639-43. DOI: 10.1038/77929

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Leverson, J.D., Joazeiro, C.A., Page, A.M., Huang, H.k., Hieter, P., Hunter, T. The APC11 RING-H2 finger mediates E2-dependent ubiquitination. (2000) Molecular Biology of the Cell. 11(7):2315-25.

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Verdecia, M.A., Huang, H., Dutil, E., Kaiser, D.A., Hunter, T., Noel, J.P. Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. (2000) Nature Structural Biology. 7(7):602-8. DOI: 10.1038/76838

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Xu, S., Huang, H.K., Kaiser, P., Latterich, M., Hunter, T. Phosphorylation and spindle pole body localization of the Cdc15p mitotic regulatory protein kinase in budding yeast. (2000) Current Biology. 10(6):329-32.

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Pao, G.M., Janknecht, R., Ruffner, H., Hunter, T., Verma, I.M. CBP/p300 interact with and function as transcriptional coactivators of BRCA1. (2000) Proceedings of the National Academy of Sciences of the United States of America. 97(3):1020-5.

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Blume-Jensen, P., Jiang, G., Hyman, R., Lee, K.F., O'Gorman, S., Hunter, T. Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility. (2000) Nature Genetics. 24(2):157-62. DOI: 10.1038/72814

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Hunter, T. Signaling--2000 and beyond. (2000) Cell. 100(1):113-27.


Buck, M., Poli, V., van der Geer, P., Chojkier, M., Hunter, T. Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha. (1999) Molecular Cell. 4(6):1087-92.

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Palmer, R.H., Fessler, L.I., Edeen, P.T., Madigan, S.J., McKeown, M., Hunter, T. DFak56 is a novel Drosophila melanogaster focal adhesion kinase. (1999) Journal of Biological Chemistry. 274(50):35621-9.

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Potter, L.R., Hunter, T. Identification and characterization of the phosphorylation sites of the guanylyl cyclase-linked natriuretic peptide receptors A and B. (1999) Methods. 19(4):506-20. DOI: 10.1006/meth.1999.0893

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Jiang, G., den Hertog, J., Su, J., Noel, J., Sap, J., Hunter, T. Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha. (1999) Nature. 401(6753):606-10. DOI: 10.1038/44170

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Jiang, W., McDonald, D., Hope, T.J., Hunter, T. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. (1999) EMBO Journal. 18(20):5703-13. DOI: 10.1093/emboj/18.20.5703

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Joazeiro, C.A., Wing, S.S., Huang, H., Leverson, J.D., Hunter, T., Liu, Y.C. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. (1999) Science. 286(5438):309-12.

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Wells, N.J., Watanabe, N., Tokusumi, T., Jiang, W., Verdecia, M.A., Hunter, T. The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression. (1999) Journal of Cell Science. 112 ( Pt 1:3361-71.

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Jiang, G., Hunter, T. Receptor signaling: when dimerization is not enough. (1999) Current Biology. 9(15):R568-71.

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Ruffner, H., Jiang, W., Craig, A.G., Hunter, T., Verma, I.M. BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site. (1999) Molecular and Cellular Biology. 19(7):4843-54.

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Potter, L.R., Hunter, T. A constitutively "phosphorylated" guanylyl cyclase-linked atrial natriuretic peptide receptor mutant is resistant to desensitization. (1999) Molecular Biology of the Cell. 10(6):1811-20.

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Biggs, W.H., Meisenhelder, J., Hunter, T., Cavenee, W.K., Arden, K.C. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. (1999) Proceedings of the National Academy of Sciences of the United States of America. 96(13):7421-6.

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Jiang, W., Wells, N.J., Hunter, T. Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. (1999) Proceedings of the National Academy of Sciences of the United States of America. 96(11):6193-8.

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Sekiguchi, T., Nishimoto, T., Hunter, T. Overexpression of D-type cyclins, E2F-1, SV40 large T antigen and HPV16 E7 rescue cell cycle arrest of tsBN462 cells caused by the CCG1/TAF(II)250 mutation. (1999) Oncogene. 18(10):1797-806. DOI: 10.1038/sj.onc.1202508

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Hunter, T. The role of tyrosine phosphorylation in cell growth and disease. (1998) Harvey Lect. 94:81-119.


Jiang, W., Jimenez, G., Wells, N.J., Hope, T.J., Wahl, G.M., Hunter, T., Fukunaga, R. PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. (1998) Molecular Cell. 2(6):877-85.

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Janknecht, R., Wells, N.J., Hunter, T. TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. (1998) Genes & Development. 12(14):2114-9.

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Blume-Jensen, P., Janknecht, R., Hunter, T. The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. (1998) Current Biology. 8(13):779-82.

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Potter, L.R., Hunter, T. Identification and characterization of the major phosphorylation sites of the B-type natriuretic peptide receptor. (1998) Journal of Biological Chemistry. 273(25):15533-9.

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Hunter, T. The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease. (1998) Philos. Trans. R. Soc. Lond., B, Biol. Sci. 353(1368):583-605. DOI: 10.1098/rstb.1998.0228

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Potter, L.R., Hunter, T. Phosphorylation of the kinase homology domain is essential for activation of the A-type natriuretic peptide receptor. (1998) Molecular and Cellular Biology. 18(4):2164-72.

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Schlaepfer, D.D., Hunter, T. Integrin signalling and tyrosine phosphorylation: just the FAKs? (1998) Trends in Cell Biology. 8(4):151-7.

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Jiang, W., Hunter, T. Analysis of cell-cycle profiles in transfected cells using a membrane-targeted GFP. (1998) BioTechniques. 24(3):349-50, 352, 354.


Sekiguchi, T., Hunter, T. Induction of growth arrest and cell death by overexpression of the cyclin-Cdk inhibitor p21 in hamster BHK21 cells. (1998) Oncogene. 16(3):369-80. DOI: 10.1038/sj.onc.1201539

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Hunter, T. Prolyl isomerases and nuclear function. (1998) Cell. 92(2):141-3.


Majeti, R., Bilwes, A.M., Noel, J.P., Hunter, T., Weiss, A. Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge. (1998) Science. 279(5347):88-91.

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Jiang, W., Hunter, T. Identification and characterization of a human protein kinase related to budding yeast Cdc7p. (1997) Proceedings of the National Academy of Sciences of the United States of America. 94(26):14320-5.

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Fischer, W.H., Hoeger, C.A., Meisenhelder, J., Hunter, T., Craig, A.G. Determination of phosphorylation sites in peptides and proteins employing a volatile Edman reagent. (1997) J. Protein Chem. 16(5):329-34.

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Ranganathan, R., Lu, K.P., Hunter, T., Noel, J.P. Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. (1997) Cell. 89(6):875-86.

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Schlaepfer, D.D., Hunter, T. Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. (1997) Journal of Biological Chemistry. 272(20):13189-95.

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Fukunaga, R., Hunter, T. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. (1997) EMBO Journal. 16(8):1921-33. DOI: 10.1093/emboj/16.8.1921

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Hunter, T., Poon, R.Y. Cdc37: a protein kinase chaperone? (1997) Trends in Cell Biology. 7(4):157-61. DOI: 10.1016/S0962-8924(97)01027-1

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Janknecht, R., Hunter, T. Convergence of MAP kinase pathways on the ternary complex factor Sap-1a. (1997) EMBO Journal. 16(7):1620-7. DOI: 10.1093/emboj/16.7.1620

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Schlaepfer, D.D., Broome, M.A., Hunter, T. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. (1997) Molecular and Cellular Biology. 17(3):1702-13.

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Poon, R.Y., Lew, J., Hunter, T. Identification of functional domains in the neuronal Cdk5 activator protein. (1997) Journal of Biological Chemistry. 272(9):5703-8.

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Janknecht, R., Hunter, T. Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase. (1997) Journal of Biological Chemistry. 272(7):4219-24.

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Hunter, T. Oncoprotein networks. (1997) Cell. 88(3):333-46.


Broome, M.A., Hunter, T. The PDGF receptor phosphorylates Tyr 138 in the c-Src SH3 domain in vivo reducing peptide ligand binding. (1997) Oncogene. 14(1):17-34. DOI: 10.1038/sj.onc.1200798

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Hunter, T., Plowman, G.D. The protein kinases of budding yeast: six score and more. (1997) Trends in Biochemical Sciences. 22(1):18-22.

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Poon, R.Y., Toyoshima, H., Hunter, T. On the masking of signals on immunoblots by cellular proteins. (1996) J. Immunol. Methods. 199(2):155-8.

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Horwitz, A.F., Hunter, T. Cell adhesion: integrating circuitry. (1996) Trends in Cell Biology. 6(12):460-1.


Schlaepfer, D.D., Hunter, T. Signal transduction from the extracellular matrix--a role for the focal adhesion protein-tyrosine kinase FAK. (1996) Cell Structure and Function. 21(5):445-50.


Schlaepfer, D.D., Hunter, T. Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. (1996) Molecular and Cellular Biology. 16(10):5623-33.

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Bilwes, A.M., den Hertog, J., Hunter, T., Noel, J.P. Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization. (1996) Nature. 382(6591):555-9. DOI: 10.1038/382555a0

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Janknecht, R., Hunter, T. Versatile molecular glue. Transcriptional control. (1996) Current Biology. 6(8):951-4.

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Broome, M.A., Hunter, T. Requirement for c-Src catalytic activity and the SH3 domain in platelet-derived growth factor BB and epidermal growth factor mitogenic signaling. (1996) Journal of Biological Chemistry. 271(28):16798-806.

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Hunter, T. Solid-state protein networks? (1996) Trends in Cell Biology. 6(7):254-5.


Sekiguchi, T., Noguchi, E., Hayashida, T., Nakashima, T., Toyoshima, H., Nishimoto, T., Hunter, T. D-type cyclin expression is decreased and p21 and p27 CDK inhibitor expression is increased when tsBN462 CCG1/TAFII250 mutant cells arrest in G1 at the restrictive temperature. (1996) Genes to Cells. 1(7):687-705.

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Winston, L.A., Hunter, T. Intracellular signalling: putting JAKs on the kinase MAP. (1996) Current Biology. 6(6):668-71.

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Poon, R.Y., Jiang, W., Toyoshima, H., Hunter, T. Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage. (1996) Journal of Biological Chemistry. 271(22):13283-91.

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Hunter, T. Tyrosine phosphorylation: past, present and future. (1996) Biochemical Society Transactions. 24(2):307-27.


Fey, M.F., Moffat, G.J., Vik, D.P., Meisenhelder, J., Saris, C.J., Hunter, T., Tack, B.F. Complete structure of the murine p36 (annexin II) gene. Identification of mRNAs for both the murine and the human gene with alternatively spliced 5' noncoding exons. (1996) Biochimica et Biophysica Acta. 1306(2-3):160-70.

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Lu, K.P., Hanes, S.D., Hunter, T. A human peptidyl-prolyl isomerase essential for regulation of mitosis. (1996) Nature. 380(6574):544-7. DOI: 10.1038/380544a0

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Ofir, R., Weinstein, Y., Bazarsky, E., Blagerman, S., Wolfson, M., Hunter, T., Rager-Zisman, B. Tyrosine phosphorylation of measles virus P-phosphoprotein in persistently infected neuroblastoma cells. (1996) Virus Genes. 13(3):203-10.

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Neet, K., Hunter, T. Vertebrate non-receptor protein-tyrosine kinase families. (1996) Genes to Cells. 1(2):147-69.

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Winston, L.A., Hunter, T. JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone. (1995) Journal of Biological Chemistry. 270(52):30837-40.

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Poon, R.Y., Hunter, T. Cell regulation. Innocent bystanders or chosen collaborators? (1995) Current Biology. 5(11):1243-7.

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Haley, A., Hunter, T., Kiberstis, P., Zimmern, D. Multiple serine phosphorylation sites on the 30 kDa TMV cell-to-cell movement protein synthesized in tobacco protoplasts. (1995) Plant Journal. 8(5):715-24.

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Poon, R.Y., Hunter, T. Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin. (1995) Science. 270(5233):90-3.

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Hunter, T. When is a lipid kinase not a lipid kinase? When it is a protein kinase. (1995) Cell. 83(1):1-4.


Poon, R.Y., Toyoshima, H., Hunter, T. Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. (1995) Molecular Biology of the Cell. 6(9):1197-213.

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Lu, K.P., Hunter, T. The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells. (1995) Progress in Cell Cycle Research. 1:187-205.

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Lu, K.P., Hunter, T. Evidence for a NIMA-like mitotic pathway in vertebrate cells. (1995) Cell. 81(3):413-24.

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Tracy, S., van der Geer, P., Hunter, T. The receptor-like protein-tyrosine phosphatase, RPTP alpha, is phosphorylated by protein kinase C on two serines close to the inner face of the plasma membrane. (1995) Journal of Biological Chemistry. 270(18):10587-94.

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Watanabe, N., Broome, M., Hunter, T. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. (1995) EMBO Journal. 14(9):1878-91.

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Hunter, T. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. (1995) Cell. 80(2):225-36.


Schlaepfer, D.D., Hanks, S.K., Hunter, T., van der Geer, P. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. (1994) Nature. 372(6508):786-91.

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Hunter, T. 1001 protein kinases redux--towards 2000. (1994) Seminars in Cell Biology. 5(6):367-76.

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Hunter, T., Pines, J. Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. (1994) Cell. 79(4):573-82.


Toyoshima, H., Hunter, T. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. (1994) Cell. 78(1):67-74.

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Zhang, S.H., Broome, M.A., Lawton, M.A., Hunter, T., Lamb, C.J. atpk1, a novel ribosomal protein kinase gene from Arabidopsis. II. Functional and biochemical analysis of the encoded protein. (1994) Journal of Biological Chemistry. 269(26):17593-9.

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Zhang, S.H., Lawton, M.A., Hunter, T., Lamb, C.J. atpk1, a novel ribosomal protein kinase gene from Arabidopsis. I. Isolation, characterization, and expression. (1994) Journal of Biological Chemistry. 269(26):17586-92.

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den Hertog, J., Tracy, S., Hunter, T. Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo. (1994) EMBO Journal. 13(13):3020-32.

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Rigaudy, P., Simon, S., Hunter, T., Sollazzo, M., Billetta, R., Zanetti, M., Eckhart, W. Antibodies specific for the neuronal form of the Src protein elicited by an antigenized antibody. (1994) DNA and Cell Biology. 13(6):585-91. DOI: 10.1089/dna.1994.13.585

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van der Geer, P., Hunter, T., Lindberg, R.A. Receptor protein-tyrosine kinases and their signal transduction pathways. (1994) Annual Review of Cell Biology. 10:251-337. DOI: 10.1146/annurev.cb.10.110194.001343


van der Geer, P., Hunter, T. Phosphopeptide mapping and phosphoamino acid analysis by electrophoresis and chromatography on thin-layer cellulose plates. (1994) Electrophoresis. 15(3-4):544-54.

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Middlemas, D.S., Meisenhelder, J., Hunter, T. Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor. (1994) Journal of Biological Chemistry. 269(7):5458-66.

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van der Geer, P., Hunter, T. Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts. (1993) EMBO Journal. 12(13):5161-72.

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Hunter, T. Braking the cycle. (1993) Cell. 75(5):839-41.


Sebastian, B., Kakizuka, A., Hunter, T. Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15. (1993) Proceedings of the National Academy of Sciences of the United States of America. 90(8):3521-4.

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Lindberg, R.A., Fischer, W.H., Hunter, T. Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine. (1993) Oncogene. 8(2):351-9.

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Meisenhelder, J., Hunter, T. The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth fact (1992) Molecular and Cellular Biology. 12(12):5843-56.

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Kikkawa, U., Mann, S.K., Firtel, R.A., Hunter, T. Molecular cloning of casein kinase II alpha subunit from Dictyostelium discoideum and its expression in the life cycle. (1992) Molecular and Cellular Biology. 12(12):5711-23.

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Pines, J., Hunter, T. Cyclins A and B1 in the human cell cycle. (1992) Ciba Found. Symp. 170:187-96; discussion 196-204.

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Hunter, T. Regulation of the eukaryotic cell cycle. Introduction. (1992) Ciba Found. Symp. 170:1-6.


Krieg, J., Hunter, T. Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin. (1992) Journal of Biological Chemistry. 267(27):19258-65.

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Hunter, T., Karin, M. The regulation of transcription by phosphorylation. (1992) Cell. 70(3):375-87.


DeMaggio, A.J., Lindberg, R.A., Hunter, T., Hoekstra, M.F. The budding yeast HRR25 gene product is a casein kinase I isoform. (1992) Proceedings of the National Academy of Sciences of the United States of America. 89(15):7008-12.

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Hunter, T., Lindberg, R.A., Middlemas, D.S., Tracy, S., van der Geer, P. Receptor protein tyrosine kinases and phosphatases. (1992) Cold Spring Harbor Symposia on Quantitative Biology. 57:25-41.

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Kakizuka, A., Sebastian, B., Borgmeyer, U., Hermans-Borgmeyer, I., Bolado, J., Hunter, T., Hoekstra, M.F., Evans, R.M. A mouse cdc25 homolog is differentially and developmentally expressed. (1992) Genes & Development. 6(4):578-90.

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Freed, E., Hunter, T. A 41-kilodalton protein is a potential substrate for the p210bcr-abl protein-tyrosine kinase in chronic myelogenous leukemia cells. (1992) Molecular and Cellular Biology. 12(3):1312-23.

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Lindberg, R.A., Quinn, A.M., Hunter, T. Dual-specificity protein kinases: will any hydroxyl do? (1992) Trends in Biochemical Sciences. 17(3):114-9.

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Pines, J., Hunter, T. Cyclin-dependent kinases: a new cell cycle motif? (1991) Trends in Cell Biology. 1(5):117-21.

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Pines, J., Hunter, T. Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. (1991) Journal of Cell Biology. 115(1):1-17.

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Hunter, T., Pines, J. Cyclins and cancer. (1991) Cell. 66(6):1071-4.


van der Geer, P., Hunter, T. Tyrosine 706 and 807 phosphorylation site mutants in the murine colony-stimulating factor-1 receptor are unaffected in their ability to bind or phosphorylate phosphatidylinositol-3 kinase but show dif (1991) Molecular and Cellular Biology. 11(9):4698-709.

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Jähner, D., Hunter, T. The stimulation of quiescent rat fibroblasts by v-src and v-fps oncogenic protein-tyrosine kinases leads to the induction of a subset of immediate early genes. (1991) Oncogene. 6(7):1259-68.

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Jähner, D., Hunter, T. The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts. (1991) Molecular and Cellular Biology. 11(7):3682-90.

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Pines, J., Hunter, T. Human cell division: the involvement of cyclins A and B1, and multiple cdc2s. (1991) Cold Spring Harbor Symposia on Quantitative Biology. 56:449-63.


Meisenhelder, J., Hunter, T. Phosphorylation of phospholipase C in vivo and in vitro. (1991) Meth. Enzymol. 197:288-305.


Boyle, W.J., van der Geer, P., Hunter, T. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. (1991) Meth. Enzymol. 201:110-49.


Nevins, J.R., Chellappan, S.P., Mudryj, M., Hiebert, S., Devoto, S., Horowitz, J., Hunter, T., Pines, J. E2F transcription factor is a target for the RB protein and the cyclin A protein. (1991) Cold Spring Harbor Symposia on Quantitative Biology. 56:157-62.


Hunter, T. Protein kinase classification. (1991) Meth. Enzymol. 200:3-37.


Inoue, J., Kerr, L.D., Ransone, L.J., Bengal, E., Hunter, T., Verma, I.M. c-rel activates but v-rel suppresses transcription from kappa B sites. (1991) Proceedings of the National Academy of Sciences of the United States of America. 88(9):3715-9.

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Boyle, W.J., Smeal, T., Defize, L.H., Angel, P., Woodgett, J.R., Karin, M., Hunter, T. Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. (1991) Cell. 64(3):573-84.

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Hunter, T. Protein-serine kinase receptors? (1991) Current Biology. 1(1):15-6.


Hunter, T. Cooperation between oncogenes. (1991) Cell. 64(2):249-70.


Middlemas, D.S., Lindberg, R.A., Hunter, T. trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. (1991) Molecular and Cellular Biology. 11(1):143-53.

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Cochet, C., Filhol, O., Payrastre, B., Hunter, T., Gill, G.N. Interaction between the epidermal growth factor receptor and phosphoinositide kinases. (1991) Journal of Biological Chemistry. 266(1):637-44.

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Lindberg, R.A., Hunter, T. cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. (1990) Molecular and Cellular Biology. 10(12):6316-24.

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Yamashita, K., Yasuda, H., Pines, J., Yasumoto, K., Nishitani, H., Ohtsubo, M., Hunter, T., Sugimura, T., Nishimoto, T. Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells. (1990) EMBO Journal. 9(13):4331-8.

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Bull, P., Morley, K.L., Hoekstra, M.F., Hunter, T., Verma, I.M. The mouse c-rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain. (1990) Molecular and Cellular Biology. 10(10):5473-85.

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Pines, J., Hunter, T. Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. (1990) Nature. 346(6286):760-3. DOI: 10.1038/346760a0

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van der Geer, P., Hunter, T. Identification of tyrosine 706 in the kinase insert as the major colony-stimulating factor 1 (CSF-1)-stimulated autophosphorylation site in the CSF-1 receptor in a murine macrophage cell line. (1990) Molecular and Cellular Biology. 10(6):2991-3002.

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Isacke, C.M., van der Geer, P., Hunter, T., Trowbridge, I.S. p180, a novel recycling transmembrane glycoprotein with restricted cell type expression. (1990) Molecular and Cellular Biology. 10(6):2606-18.

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Pines, J., Hunter, T. p34cdc2: the S and M kinase? (1990) New Biol. 2(5):389-401.

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Hunter, T., Lindberg, R.A., Middlemas, D.S. Novel receptor protein-tyrosine kinases. (1990) Adv. Second Messenger Phosphoprotein Res. 24:260-5.


Amiguet, P., D'Eustachio, P., Kristensen, T., Wetsel, R.A., Saris, C.J., Hunter, T., Chaplin, D.D., Tack, B.F. Structure and chromosome assignment of the murine p36 (calpactin I heavy chain) gene. (1990) Biochemistry. 29(5):1226-32.

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Gould, K.L., Bretscher, A., Esch, F.S., Hunter, T. cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1. (1989) EMBO Journal. 8(13):4133-42.

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Hunter, T. Protein modification: phosphorylation on tyrosine residues. (1989) Current Opinion in Cell Biology. 1(6):1168-81.


Bull, P., Hunter, T., Verma, I.M. Transcriptional induction of the murine c-rel gene with serum and phorbol-12-myristate-13-acetate in fibroblasts. (1989) Molecular and Cellular Biology. 9(11):5239-43.

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Defize, L.H., Boonstra, J., Meisenhelder, J., Kruijer, W., Tertoolen, L.G., Tilly, B.C., Hunter, T., van Bergen en Henegouwen, P.M., Moolenaar, W.H., de Laat, S.W. Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptors. (1989) Journal of Cell Biology. 109(5):2495-507.

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Freed, E., Gailit, J., van der Geer, P., Ruoslahti, E., Hunter, T. A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C. (1989) EMBO Journal. 8(10):2955-65.

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Hunter, T. Protein-tyrosine phosphatases: the other side of the coin. (1989) Cell. 58(6):1013-6.


Pines, J., Hunter, T. Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. (1989) Cell. 58(5):833-46.

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Meisenhelder, J., Suh, P.G., Rhee, S.G., Hunter, T. Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro. (1989) Cell. 57(7):1109-22.

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Hunter, T. The functions of oncogene products. (1989) Prog. Clin. Biol. Res. 288:25-34.


Nunn, M.F., Hunter, T. The ets sequence is required for induction of erythroblastosis in chickens by avian retrovirus E26. (1989) Journal of Virology. 63(1):398-402.

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Isacke, C.M., Lindberg, R.A., Hunter, T. Synthesis of p36 and p35 is increased when U-937 cells differentiate in culture but expression is not inducible by glucocorticoids. (1989) Molecular and Cellular Biology. 9(1):232-40.

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Gould, K.L., Bilezikjian, L.M., Hunter, T. AtT20 cells express modified forms of pp60c-src. (1989) Molecular Endocrinology. 3(1):79-88. DOI: 10.1210/mend-3-1-79

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Lindberg, R.A., Thompson, D.P., Hunter, T. Identification of cDNA clones that code for protein-tyrosine kinases by screening expression libraries with antibodies against phosphotyrosine. (1988) Oncogene. 3(6):629-33.

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Weinmaster, G.A., Hunter, T. Investigation of the role of P130gag-fps in transformation: generation and use of a temperature-sensitive mutant P130gag-fps. (1988) Journal of Virology. 62(10):3849-54.

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Meisenhelder, J., Hunter, T. Radioactive protein-labelling techniques. (1988) Nature. 335(6186):120. DOI: 10.1038/335120a0


Defize, L.H., Arndt-Jovin, D.J., Jovin, T.M., Boonstra, J., Meisenhelder, J., Hunter, T., de Hey, H.T., de Laat, S.W. A431 cell variants lacking the blood group A antigen display increased high affinity epidermal growth factor-receptor number, protein-tyrosine kinase activity, and receptor turnover. (1988) Journal of Cell Biology. 107(3):939-49.

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Gould, K.L., Hunter, T. Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity. (1988) Molecular and Cellular Biology. 8(8):3345-56.

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Chiu, R., Boyle, W.J., Meek, J., Smeal, T., Hunter, T., Karin, M. The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. (1988) Cell. 54(4):541-52.

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Hanks, S.K., Quinn, A.M., Hunter, T. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. (1988) Science. 241(4861):42-52.

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Weinmaster, G.A., Middlemas, D.S., Hunter, T. A major site of tyrosine phosphorylation within the SH2 domain of Fujinami sarcoma virus P130gag-fps is not required for protein-tyrosine kinase activity or transforming potential. (1988) Journal of Virology. 62(6):2016-25.

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Hunter, T., Angel, P., Boyle, W.J., Chiu, R., Freed, E., Gould, K.L., Isacke, C.M., Karin, M., Lindberg, R.A., van der Geer, P. Targets for signal-transducing protein kinases. (1988) Cold Spring Harbor Symposia on Quantitative Biology. 53 Pt 1:131-42.


Cartwright, C.A., Simantov, R., Cowan, W.M., Hunter, T., Eckhart, W. pp60c-src expression in the developing rat brain. (1988) Proceedings of the National Academy of Sciences of the United States of America. 85(10):3348-52.

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Hunter, T. The Ca2+/phospholipid-binding proteins of the submembraneous skeleton. (1988) Advances in Experimental Medicine and Biology. 234:169-93.


Angel, P., Allegretto, E.A., Okino, S.T., Hattori, K., Boyle, W.J., Hunter, T., Karin, M. Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. (1988) Nature. 332(6160):166-71. DOI: 10.1038/332166a0

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Hunter, T. A thousand and one protein kinases. (1987) Cell. 50(6):823-9.


Bilezikjian, L.M., Woodgett, J.R., Hunter, T., Vale, W.W. Phorbol ester-induced down-regulation of protein kinase C abolishes vasopressin-mediated responses in rat anterior pituitary cells. (1987) Molecular Endocrinology. 1(8):555-60. DOI: 10.1210/mend-1-8-555

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Saris, C.J., Kristensen, T., D'Eustachio, P., Hicks, L.J., Noonan, D.J., Hunter, T., Tack, B.F. cDNA sequence and tissue distribution of the mRNA for bovine and murine p11, the S100-related light chain of the protein-tyrosine kinase substrate p36 (calpactin I). (1987) Journal of Biological Chemistry. 262(22):10663-71.

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Woodgett, J.R., Hunter, T. Regulation of protein kinase C by activators, Ca2+, and phosphorylation. (1987) Prog. Clin. Biol. Res. 249:237-47.


Cartwright, C.A., Simantov, R., Kaplan, P.L., Hunter, T., Eckhart, W. Alterations in pp60c-src accompany differentiation of neurons from rat embryo striatum. (1987) Molecular and Cellular Biology. 7(5):1830-40.

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Woodgett, J.R., Hunter, T. Isolation and characterization of two distinct forms of protein kinase C. (1987) Journal of Biological Chemistry. 262(10):4836-43.

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Woodgett, J.R., Hunter, T. Immunological evidence for two physiological forms of protein kinase C. (1987) Molecular and Cellular Biology. 7(1):85-96.

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Woodgett, J.R., Gould, K.L., Hunter, T. Substrate specificity of protein kinase C. Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements. (1986) European Journal of Biochemistry. 161(1):177-84.

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Isacke, C.M., Meisenhelder, J., Brown, K.D., Gould, K.L., Gould, S.J., Hunter, T. Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide. (1986) EMBO Journal. 5(11):2889-98.

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Glenney, J.R., Boudreau, M., Galyean, R., Hunter, T., Tack, B. Association of the S-100-related calpactin I light chain with the NH2-terminal tail of the 36-kDa heavy chain. (1986) Journal of Biological Chemistry. 261(23):10485-8.

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Kristensen, T., Saris, C.J., Hunter, T., Hicks, L.J., Noonan, D.J., Glenney, J.R., Tack, B.F. Primary structure of bovine calpactin I heavy chain (p36), a major cellular substrate for retroviral protein-tyrosine kinases: homology with the human phospholipase A2 inhibitor lipocortin. (1986) Biochemistry. 25(16):4497-503.

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Tripp, M.L., Piñon, R., Meisenhelder, J., Hunter, T. Identification of phosphoproteins correlated with proliferation and cell cycle arrest in Saccharomyces cerevisiae: positive and negative regulation by cAMP-dependent protein kinase. (1986) Proceedings of the National Academy of Sciences of the United States of America. 83(16):5973-7.

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Saris, C.J., Tack, B.F., Kristensen, T., Glenney, J.R., Hunter, T. The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats. (1986) Cell. 46(2):201-12.

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Hunter, T. Cancer. Cell growth control mechanisms. (1986) Nature. 322(6074):14-6. DOI: 10.1038/322014a0


Isacke, C.M., Trowbridge, I.S., Hunter, T. Modulation of p36 phosphorylation in human cells: studies using anti-p36 monoclonal antibodies. (1986) Molecular and Cellular Biology. 6(7):2745-51.

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Gould, K.L., Woodgett, J.R., Isacke, C.M., Hunter, T. The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo. (1986) Molecular and Cellular Biology. 6(7):2738-44.

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Patschinsky, T., Hunter, T., Sefton, B.M. Phosphorylation of the transforming protein of Rous sarcoma virus: direct demonstration of phosphorylation of serine 17 and identification of an additional site of tyrosine phosphorylation in p60v-src (1986) Journal of Virology. 59(1):73-81.

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Sefton, B.M., Hunter, T. From c-src to v-src, or the case of the missing C terminus. (1986) Cancer Surveys. 5(2):159-72.

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Cartwright, C.A., Kaplan, P.L., Cooper, J.A., Hunter, T., Eckhart, W. Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigen. (1986) Molecular and Cellular Biology. 6(5):1562-70.

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Cooper, J.A., Gould, K.L., Cartwright, C.A., Hunter, T. Tyr527 is phosphorylated in pp60c-src: implications for regulation. (1986) Science. 231(4744):1431-4.

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Gould, K.L., Cooper, J.A., Bretscher, A., Hunter, T. The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein. (1986) Journal of Cell Biology. 102(2):660-9.

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Cooper, J.A., Hunter, T. Major substrate for growth factor-activated protein-tyrosine kinases is a low-abundance protein. (1985) Molecular and Cellular Biology. 5(11):3304-9.

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Gould, K.L., Woodgett, J.R., Cooper, J.A., Buss, J.E., Shalloway, D., Hunter, T. Protein kinase C phosphorylates pp60src at a novel site. (1985) Cell. 42(3):849-57.

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Coussens, P.M., Cooper, J.A., Hunter, T., Shalloway, D. Restriction of the in vitro and in vivo tyrosine protein kinase activities of pp60c-src relative to pp60v-src. (1985) Molecular and Cellular Biology. 5(10):2753-63.

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Hunter, T., Cooper, J.A. Protein-tyrosine kinases. (1985) Annual Review of Biochemistry. 54:897-930. DOI: 10.1146/annurev.bi.54.070185.004341


Hunter, T. Cell-surface proteins. At last the insulin receptor. (1985) Nature. 313(6005):740-1.


Hunter, T., Alexander, C.B., Cooper, J.A. Protein phosphorylation and growth control. (1985) Ciba Found. Symp. 116:188-204.

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Kruijer, W., Cooper, J.A., Hunter, T., Verma, I.M. Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. (1984) Nature. 312(5996):711-6.

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Voronova, A.F., Buss, J.E., Patschinsky, T., Hunter, T., Sefton, B.M. Characterization of the protein apparently responsible for the elevated tyrosine protein kinase activity in LSTRA cells. (1984) Molecular and Cellular Biology. 4(12):2705-13.

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Hunter, T., Ling, N., Cooper, J.A. Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane. (1984) Nature. 311(5985):480-3.

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Hunter, T. The epidermal growth factor receptor gene and its product. (1984) Nature. 311(5985):414-6.


Hunter, T., Gould, K.L., Cooper, J.A. Tyrosine protein kinases, viral transformation and the control of cell proliferation. (1984) Biochemical Society Transactions. 12(5):757-9.


Hunter, T. Oncogenes and proto-oncogenes: how do they differ? (1984) J. Natl. Cancer Inst. 73(4):773-86.


Hunter, T. The proteins of oncogenes. (1984) Sci. Am. 251(2):70-9.


Cooper, J.A., Esch, F.S., Taylor, S.S., Hunter, T. Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. (1984) Journal of Biological Chemistry. 259(12):7835-41.

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Hunter, T., Cooper, J.A. Tyrosine protein kinases and their substrates: an overview. (1984) Adv Cyclic Nucleotide Protein Phosphorylation Res. 17:443-55.


Donoghue, D.J., Anderson, C., Hunter, T., Kaplan, P.L. Transmission of the polyoma virus middle T gene as the oncogene of a murine retrovirus. (1984) Nature. 308(5961):748-50.

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Cochet, C., Gill, G.N., Meisenhelder, J., Cooper, J.A., Hunter, T. C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity. (1984) Journal of Biological Chemistry. 259(4):2553-8.

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Gould, K.L., Cooper, J.A., Hunter, T. The 46,000-dalton tyrosine protein kinase substrate is widespread, whereas the 36,000-dalton substrate is only expressed at high levels in certain rodent tissues. (1984) Journal of Cell Biology. 98(2):487-97.

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Hunter, T., Hutchinson, M.A., Eckhart, W. Polyoma middle-sized T antigen can be phosphorylated on tyrosine at multiple sites in vitro. (1984) EMBO Journal. 3(1):73-9.

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Cooper, J.A., Sefton, B.M., Hunter, T. Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells. (1984) Molecular and Cellular Biology. 4(1):30-7.

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Sefton, B.M., Hunter, T. Tyrosine protein kinases. (1984) Adv Cyclic Nucleotide Protein Phosphorylation Res. 18:195-226.


Cooper, J.A., Scolnick, E.M., Ozanne, B., Hunter, T. Epidermal growth factor receptor metabolism and protein kinase activity in human A431 cells infected with Snyder-Theilen feline sarcoma virus or harvey or Kirsten murine sarcoma virus. (1983) Journal of Virology. 48(3):752-64.

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Zimmern, D., Hunter, T. Point mutation in the 30-K open reading frame of TMV implicated in temperature-sensitive assembly and local lesion spreading of mutant Ni 2519. (1983) EMBO Journal. 2(11):1893-900.

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Nigg, E.A., Cooper, J.A., Hunter, T. Immunofluorescent localization of a 39,000-dalton substrate of tyrosine protein kinases to the cytoplasmic surface of the plasma membrane. (1983) Journal of Cell Biology. 96(6):1601-9.

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Cooper, J.A., Sefton, B.M., Hunter, T. Detection and quantification of phosphotyrosine in proteins. (1983) Meth. Enzymol. 99:387-402.


Papkoff, J., Nigg, E.A., Hunter, T. The transforming protein of Moloney murine sarcoma virus is a soluble cytoplasmic protein. (1983) Cell. 33(1):161-72.

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Cooper, J., Nakamura, K.D., Hunter, T., Weber, M.J. Phosphotyrosine-containing proteins and expression of transformation parameters in cells infected with partial transformation mutants of Rous sarcoma virus. (1983) Journal of Virology. 46(1):15-28.

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Cooper, J.A., Reiss, N.A., Schwartz, R.J., Hunter, T. Three glycolytic enzymes are phosphorylated at tyrosine in cells transformed by Rous sarcoma virus. (1983) Nature. 302(5905):218-23.


Papkoff, J., Hunter, T. Detection of an 85,000-dalton phosphoprotein in ts110 murine sarcoma virus-infected cells with antiserum against a v-mos peptide. (1983) Journal of Virology. 45(3):1177-82.

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Hunter, T., Cooper, J.A. Role of tyrosine phosphorylation in malignant transformation by viruses and in cellular growth control. (1983) Progress in Nucleic Acid Research and Molecular Biology. 29:221-32.


Hunter, T., Jackson, R., Zimmern, D. Multiple proteins and subgenomic mRNAs may be derived from a single open reading frame on tobacco mosaic virus RNA. (1983) Nucleic Acids Research. 11(3):801-21.

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Donoghue, D.J., Hunter, T. Recombinational junctions of variants of Moloney murine sarcoma virus: generation and divergence of a mammalian transforming gene. (1983) Journal of Virology. 45(2):607-17.

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Cooper, J.A., Hunter, T. Regulation of cell growth and transformation by tyrosine-specific protein kinases: the search for important cellular substrate proteins. (1983) Current Topics in Microbiology and Immunology. 107:125-61.


Cooper, J.A., Hunter, T. Identification and characterization of cellular targets for tyrosine protein kinases. (1983) Journal of Biological Chemistry. 258(2):1108-15.

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Sefton, B.M., Hunter, T., Cooper, J.A. Some lymphoid cell lines transformed by Abelson murine leukemia virus lack a major 36,000-dalton tyrosine protein kinase substrate. (1983) Molecular and Cellular Biology. 3(1):56-63.

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Cooper, J.A., Bowen-Pope, D.F., Raines, E., Ross, R., Hunter, T. Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins. (1982) Cell. 31(1):263-73.

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Nigg, E.A., Sefton, B.M., Hunter, T., Walter, G., Singer, S.J. Immunofluorescent localization of the transforming protein of Rous sarcoma virus with antibodies against a synthetic src peptide. (1982) Proceedings of the National Academy of Sciences of the United States of America. 79(17):5322-6.

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Adkins, B., Hunter, T. Two structurally and functionally different forms of the transforming protein of PRC II avian sarcoma virus. (1982) Molecular and Cellular Biology. 2(8):890-6.

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Papkoff, J., Hunter, T. Identification of proteins encoded by the Gazdar murine sarcoma virus genome by in vitro translation and comparison with Moloney murine sarcoma virus 124. (1982) Journal of Virology. 43(2):533-43.

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Adkins, B., Hunter, T., Sefton, B.M. The transforming proteins of PRCII virus and Rous sarcoma virus form a complex with the same two cellular phosphoproteins. (1982) Journal of Virology. 43(2):448-55.

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Cooper, J.A., Hunter, T. Discrete primary locations of a tyrosine-protein kinase and of three proteins that contain phosphotyrosine in virally transformed chick fibroblasts. (1982) Journal of Cell Biology. 94(2):287-96.

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Walter, G., Hutchinson, M.A., Hunter, T., Eckhart, W. Purification of polyoma virus medium-size tumor antigen by immunoaffinity chromatography. (1982) Proceedings of the National Academy of Sciences of the United States of America. 79(13):4025-9.

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Hunter, T. Phosphotyrosine - a new protein modification. (1982) Trends in Biochemical Sciences. 7(7):246-249. DOI: 10.1016/0968-0004(82)90035-4

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Papkoff, J., Verma, I.M., Hunter, T. Detection of a transforming gene product in cells transformed by Moloney murine sarcoma virus. (1982) Cell. 29(2):417-26.

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Sefton, B.M., Hunter, T., Nigg, E.A., Singer, S.J., Walter, G. Cytoskeletal targets for viral transforming proteins with tyrosine protein kinase activity. (1982) Cold Spring Harbor Symposia on Quantitative Biology. 46 Pt 2:939-51.


Hunter, T. Synthetic peptide substrates for a tyrosine protein kinase. (1982) Journal of Biological Chemistry. 257(9):4843-8.

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Donoghue, D.J., Hunter, T. A generalized method of subcloning DNA fragments by restriction site reconstruction: application to sequencing the amino-terminal coding region of the transforming gene of Gazdar murine sarcoma virus. (1982) Nucleic Acids Research. 10(8):2549-64.

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Papkoff, J., Lai, M.H., Hunter, T. Analysis of v-mos encoded proteins in cells transformed by several related murine sarcoma viruses. (1982) J. Cell. Biochem. 19(4):349-62. DOI: 10.1002/jcb.240190405

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Sefton, B.M., Patschinsky, T., Berdot, C., Hunter, T., Elliott, T. Phosphorylation and metabolism of the transforming protein of Rous sarcoma virus. (1982) Journal of Virology. 41(3):813-20.

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Patschinsky, T., Hunter, T., Esch, F.S., Cooper, J.A., Sefton, B.M. Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation. (1982) Proceedings of the National Academy of Sciences of the United States of America. 79(4):973-7.

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Donoghue, D.J., Hunter, T. Expression of transforming region of Moloney murine sarcoma virus in Escherichia coli as a fusion protein with small tumor antigen of polyoma virus. (1982) Proceedings of the National Academy of Sciences of the United States of America. 79(3):800-4.

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Cooper, J.A., Hunter, T. Similarities and differences between the effects of epidermal growth factor and Rous sarcoma virus. (1981) Journal of Cell Biology. 91(3 Pt 1):878-83.

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Papkoff, J., Lai, M.H., Hunter, T., Verma, I.M. Analysis of transforming gene products from Moloney murine sarcoma virus. (1981) Cell. 27(1 Pt 2):109-19.

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Walter, G., Hutchinson, M.A., Hunter, T., Eckhart, W. Antibodies specific for the polyoma virus middle-size tumor antigen. (1981) Proceedings of the National Academy of Sciences of the United States of America. 78(8):4882-6.

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Adkins, B., Hunter, T. Identification of a packaged cellular mRNA in virions of rous sarcoma virus. (1981) Journal of Virology. 39(2):471-80.

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Hunter, T., Cooper, J.A. Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells. (1981) Cell. 24(3):741-52.

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Cooper, J.A., Hunter, T. Four different classes of retroviruses induce phosphorylation of tyrosines present in similar cellular proteins. (1981) Molecular and Cellular Biology. 1(5):394-407.

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Sefton, B.M., Hunter, T., Ball, E.H., Singer, S.J. Vinculin: a cytoskeletal target of the transforming protein of Rous sarcoma virus. (1981) Cell. 24(1):165-74.

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Sefton, B.M., Hunter, T., Raschke, W.C. Evidence that the Abelson virus protein functions in vivo as a protein kinase that phosphorylates tyrosine. (1981) Proceedings of the National Academy of Sciences of the United States of America. 78(3):1552-6.

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Cooper, J.A., Hunter, T. Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells. (1981) Molecular and Cellular Biology. 1(2):165-78.

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Eckhart, W., Delbrück, S., Deininger, P., Friedmann, T., Hunter, T. A mutation increasing the size of the polyoma virion proteins, VP2 and VP3. (1981) Virology. 109(1):35-46.


Hunter, T. Protein phosphorylated by the RSV transforming function. (1980) Cell. 22(3):647-8.


Mann, K., Hunter, T. Phosphorylation of SV40 large T antigen in SV40 nucleoprotein complexes. (1980) Virology. 107(2):526-32.


Sefton, B.M., Hunter, T., Beemon, K., Eckhart, W. Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus. (1980) Cell. 20(3):807-16.


Hunter, T., Sefton, B.M., Beemon, K. Studies on the structure and function of the avian sarcoma virus transforming-gene product. (1980) Cold Spring Harbor Symposia on Quantitative Biology. 44 Pt 2,:931-41.

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Sefton, B.M., Hunter, T., Beemon, K. Relationship of polypeptide products of the transforming gene of Rous sarcoma virus and the homologous gene of vertebrates. (1980) Proceedings of the National Academy of Sciences of the United States of America. 77(4):2059-63.

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Hunter, T., Hutchinson, M.A., Eckhart, W., Friedmann, T., Esty, A., La Porte, P., Deininger, P. Organization of T antigens in the polyoma virus genome. (1980) Cold Spring Harbor Symposia on Quantitative Biology. 44 Pt 1,:131-9.


Hunter, T., Sefton, B.M. Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. (1980) Proceedings of the National Academy of Sciences of the United States of America. 77(3):1311-5.

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Papkoff, J., Hunter, T., Beemon, K. In vitro translation of virion RNA from Moloney murine sarcoma virus. (1980) Virology. 101(1):91-103.


Sefton, B.M., Hunter, T., Beemon, K. Temperature-sensitive transformation by Rous sarcoma virus and temperature-sensitive protein kinase activity. (1980) Journal of Virology. 33(1):220-9.

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Hunter, T., Hutchinson, M.A., Eckhart, W., Friedmann, T., Esty, A., LaPorte, P., Deininger, P. Regions of the polyoma genome coding for T antigens. (1979) Nucleic Acids Research. 7(8):2275-88.

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Eckhart, W., Hutchinson, M.A., Hunter, T. An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates. (1979) Cell. 18(4):925-33.

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Garrels, J.I., Hunter, T. Post-translational modification of actins synthesized in vitro. (1979) Biochimica et Biophysica Acta. 564(3):517-25.

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Lawrence, C., Hunter, T., Walter, G. Characterization of the simian virus 40-specific messenger RNAs isolated from HeLa cells infected with the non-defective adenovirus 2-simian virus 40 hybrid viruses Ad2+ND2 and Ad2+ND4. (1979) Journal of Molecular Biology. 134(1):95-108.


Hunter, T. Functional characterization of the early and late mRNAs of simian virus 40. (1979) Virology. 95(2):511-22.


Westphal, H., Lai, S.P., Lawrence, C., Hunter, T., Walter, G. Mosaic adenovirus-SV40 RNA specified by the non-defective hybrid virus Ad2+ND4. (1979) Journal of Molecular Biology. 130(3):337-51.


Sefton, B.M., Hunter, T., Beemon, K. Product of in vitro translation of the Rous sarcoma virus src gene has protein kinase activity. (1979) Journal of Virology. 30(1):311-8.

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Beemon, K., Hunter, T., Sefton, B.M. Polymorphism of avian sarcoma virus src proteins. (1979) Journal of Virology. 30(1):190-200.

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Linke, H.K., Hunter, T., Walter, G. Structural relationship between the 100,000- and 17,000- molecular-weight T antigens of simian virus 40 (SV40) as deduced by comparison with the SV40-specific proteins coded by the nondefective adenov (1979) Journal of Virology. 29(1):390-4.

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Mann, K., Hunter, T. Association of simian virus 40 T antigen with simian virus 40 nucleoprotein complexes. (1979) Journal of Virology. 29(1):232-41.

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Hunter, T., Hutchinson, M.A., Eckhart, W. Translation of polyoma virus T antigens in vitro. (1978) Proceedings of the National Academy of Sciences of the United States of America. 75(12):5917-21.

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Sefton, B.M., Beemon, K., Hunter, T. Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo. (1978) Journal of Virology. 28(3):957-71.

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Beemon, K., Hunter, T. Characterization of Rous sarcoma virus src gene products synthesized in vitro. (1978) Journal of Virology. 28(2):551-66.

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Hunter, T., Gibson, W. Characterization of the mRNA's for the polyoma virus capsid proteins VP1, VP2, and VP3. (1978) Journal of Virology. 28(1):240-53.

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Hutchinson, M.A., Hunter, T., Eckhart, W. Characterization of T antigens in polyoma-infected and transformed cells. (1978) Cell. 15(1):65-77.

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Hunter, T., Francke, B., Bacheler, L. In vitro polyoma DNA synthesis: asymmetry of short DNA chains. (1977) Cell. 12(4):1021-8.


Hunter, T., Garrels, J.I. Characterization of the mRNAs for alpha-, beta- and gamma-actin. (1977) Cell. 12(3):767-81.


Mann, K., Hunter, T., Walter, G., Linke, H. Evidence for simian virus 40 (SV40) coding of SV40 T-antigen and the SV40-specific proteins in HeLa cells infected with nondefective adenovirus type 2-SV40 hybrid viruses. (1977) Journal of Virology. 24(1):151-69.

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Beemon, K., Hunter, T. In vitro translation yields a possible Rous sarcoma virus src gene product. (1977) Proceedings of the National Academy of Sciences of the United States of America. 74(8):3302-6.

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Gibson, W., Hunter, T., Cogen, B., Eckhart, W. Altered virion proteins of a temperature-sensitive mutant of polyoma virus, ts59. (1977) Virology. 80(1):21-41.


Hunter, A.R., Jackson, R.J., Hunt, T. The role of complexes between the 40-S ribosomal subunit and Met-tRNA-Met-f in the initiation of protein synthesis in the wheat-germ system. (1977) European Journal of Biochemistry. 75(1):159-70. DOI: 10.1111/j.1432-1033.1977.tb11513.x


Hunter, A.R., Farrell, P.J., Jackson, R.J., Hunt, T. The role of polyamines in cell-free protein synthesis in the wheat-germ system. (1977) European Journal of Biochemistry. 75(1):149-57. DOI: 10.1111/j.1432-1033.1977.tb11512.x


Hunter, T.R., Hunt, T., Knowland, J., Zimmern, D. Messenger RNA for the coat protein of tobacco mosaic virus. (1976) Nature. 260(5554):759-64.

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Robbins, J.C., Hunter, T.R., Nicolson, G.L. Ricinus communis toxin-mediated inhibition of protein synthesis in cell-free extracts of a toxin-resistant variant mouse lymphoma cell line. (1976) Journal of Supramolecular Structure. 5(4):515(367)-520(372). DOI: 10.1002/jss.400050408

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Hunter, A.R., Jackson, R.J. Control of haemoglobin synthesis. The effects of iron deprivation, cobalt and temperature on the rate and extent of globin synthesis in reticulocytes. (1975) European Journal of Biochemistry. 58(2):421-30. DOI: 10.1111/j.1432-1033.1975.tb02389.x

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Rudland, P.S., Weil, S., Hunter, A.R. Changes in RNA metabolism and accumulation of presumptive messenger RNA during transition from the growing to the quiescent state of cultured mouse fibroblasts. (1975) Journal of Molecular Biology. 96(4):745-66. DOI: 10.1016/0022-2836(75)90150-3


Hunter, T., Francke, B. In vitro polyoma DNA synthesis: inhibition by 1-beta-d-arabinofuranosyl CTP. (1975) Journal of Virology. 15(4):759-75.

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Robertson, H.D., Hunter, T. Sensitive methods for the detection and characterization of double helical ribonucleic acid. (1975) Journal of Biological Chemistry. 250(2):418-25.

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Hunter, T., Hunt, T., Jackson, R.J., Robertson, H.D. The characteristics of inhibition of protein synthesis by double-stranded ribonucleic acid in reticulocyte lysates. (1975) Journal of Biological Chemistry. 250(2):409-17.

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Francke, B., Hunter, T. In vitro polyoma DNA synthesis: requirement for cytoplasmic factors. (1975) Journal of Virology. 15(1):97-107.

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Nicolson, G.L., Lacorbiere, M., Hunter, T.R. Mechanism of cell entry and toxicity of an affinity- purified lectin from Ricinus communis and its differential effects on normal and virus-transformed fibroblasts. (1975) Cancer Research. 35(1):144-55.

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Francke, B., Hunter, T. In vitro polyoma DNA synthesis: discontinuous chain growth. (1974) Journal of Molecular Biology. 83(1):99-121.


Hunter, T., Francke, B. Letter: In vitro polyoma DNA synthesis: involvement of RNA in discontinuous chain growth. (1974) Journal of Molecular Biology. 83(1):123-30.


Francke, B., Hunter, T. In vitro polyoma DNA synthesis: studies on an early temperature-sensitive mutant. (1974) Journal of Virology. 13(1):241-3.

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Hunter, T., Francke, B. In vitro polyoma DNA synthesis: characterization of a system from infected 3T3 cells. (1974) Journal of Virology. 13(1):125-39.

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Hunter, A.R., Jackson, R.J. Control of haemoglobin synthesis: coordination of alpha and beta chain synthesis. (1972) Hamatol. Bluttransfus. 10:95-108.


Hunter, A.R., Hunt, R.T., Jackson, R.J., Robertson, H.D. Initiation of globin synthesis in rabbit reticulocyte cell-free systems: inhibition by double-stranded RNA. (1972) Hamatol. Bluttransfus. 10:133-45.


Hunter, A.R., Jackson, R.J. The origin and nature of the methionine residue initiating the synthesis of haemoglobin in vivo and in vitro. (1971) European Journal of Biochemistry. 19(3):316-22. DOI: 10.1111/j.1432-1033.1971.tb01321.x


Jackson, R., Hunter, T. Role of methionine in the initiation of haemoglobin synthesis. (1970) Nature. 227(5259):672-6.


Hunter, A.R., Jackson, R.J. Miscoding by Escherichia coli tRNAs for methionine, cysteine and valine in the synthesis of rabbit globin. (1970) European Journal of Biochemistry. 15(2):381-90. DOI: 10.1111/j.1432-1033.1970.tb01019.x


Jackson, R., Hunter, T. The effect of cobalt on the synthesis of globin and haem in reticulocytes. (1970) FEBS Lett. 9(2):61-63.


Hunter, T., Munro, A. Allelic variants in the amino-acid sequence of the alpha chain of rabbit haemoglobin. (1969) Nature. 223(5212):1270-2.


Hunt, R.T., Hunter, A.R., Munro, A.J. The control of haemoglobin synthesis: factors controlling the output of alpha and beta chains. (1969) Proc Nutr Soc. 28(2):248-54. DOI: 10.1079/pns19690046


Hunt, T., Hunter, T., Munro, A. Control of haemoglobin synthesis: rate of translation of the messenger RNA for the alpha and beta chains. (1969) Journal of Molecular Biology. 43(1):123-33.


Hunt, T., Hunter, A., Munro, A.J. Factors affecting haemoglobin biosynthesis. (1969) Biochemical Journal. 113(2):5P. DOI: 10.1042/bj1130005pa


Hunter, A.R., Korner, A. The response of rat liver polysomes to added homopolynucleotides: the removal of inactive ribosomes. (1969) Biochimica et Biophysica Acta. 179(1):115-28. DOI: 10.1016/0005-2787(69)90127-0


Hunter, A.R., Korner, A. Exonuclease activity in rat liver cell sap. (1968) Biochimica et Biophysica Acta. 169(2):488-93. DOI: 10.1016/0005-2787(68)90057-9


Hunt, R.T., Hunter, A.R., Munro, A.J. Control of haemoglobin synthesis: a difference in the size of the polysomes making alpha and beta chains. (1968) Nature. 220(5166):481-3. DOI: 10.1038/220481a0


Hunt, T., Hunter, T., Munro, A. Control of haemoglobin synthesis: distribution of ribosomes on the messenger RNA for alpha and beta chains. (1968) Journal of Molecular Biology. 36(1):31-45.


Hunter, A.R., Jefferson, L.S. Perfusion of rat liver with adenosine monophosphate. (1967) Biochemical Journal. 104(3):60P-61P.


Education

BA, First Class Honors, University of Cambridge, England
PhD, University of Cambridge, England
Postdoctoral Fellow, The Salk Institute and University of Cambridge


Awards & Honors

  • 2019 National Cancer Institute Outstanding Investigator
  • 2018 Tang Prize in Biopharmaceutical Science
  • 2018 Pezcoller–AACR International Award for Extraordinary Achievement in Cancer Research
  • 2017 Sjöberg Prize for Cancer Research
  • 2014 Royal Medal in Biological Sciences
  • 2013 Fellow, AACR Academy
  • 2013 Einstein Professor, Chinese Academy of Sciences
  • 2012 Thomson-Reuters Citation Laureate
  • 2011 Signal Transduction Society Honorary Medal
  • 2011 Lifetime Achievement in Cancer Research Award, Jefferson Kimmel Cancer Center
  • 2007 Clifford Prize for Cancer Research
  • 2006 Robert J. and Claire Pasarow award for Cancer Research
  • 2006 Daniel Nathan's Memorial Award
  • 2005 Wolf Prize in Medicine
  • 2004 Louisa Gross Horwitz Prize
  • 2004 Prince of Asturias Award for Scientific and Technical Research
  • 2004 Kirk A. Landon-AACR Prize for Basic Cancer Research
  • 2004 American Cancer Society Medal of Honor
  • 2003 City of Medicine Award
  • 2003 Sergio Lombroso Award in Cancer Research
  • 2001 Keio Medical Science Prize
  • 2000 J. Allyn Taylor International Prize in Medicine
  • 1994 Gairdner Foundation International Award
  • 1994 General Motors Cancer Research Foundation Prize
  • American Cancer Society Research Professorship
  • Member of the American Philosophical Society
  • Member of the National Academy of Medicine
  • Fellow of the American Academy of Arts and Sciences
  • Member of the United States National Academy of Sciences
  • Fellow of the Royal Society of London