Tatyana Sharpee

Professor

Computational Neurobiology Laboratory

Salk Institute for Biological Studies - Publications

all Publications


Sharpee, T.O., Berkowitz, J.A. Linking neural responses to behavior with information-preserving population vectors (2019) Current Opinion in Behavioral Sciences. 29:37-44. DOI: https://doi.org/10.1016/j.cobeha.2019.03.004

+ expand abstract


Amatya, D.N., Linker, S.B., Mendes, A.P.D., Santos, R., Erikson, G., Shokhirev, M.N., Zhou, Y., Sharpee, T., Gage, F.H., Marchetto, M.C., Kim, Y. Dynamical Electrical Complexity Is Reduced during Neuronal Differentiation in Autism Spectrum Disorder. (2019) Stem Cell Reports. DOI: 10.1016/j.stemcr.2019.08.001

+ expand abstract


Sharpee, T.O. An argument for hyperbolic geometry in neural circuits. (2019) Current Opinion in Neurobiology. 58:101-104. DOI: 10.1016/j.conb.2019.07.008

+ expand abstract


Berkowitz, J.A., Sharpee, T.O. Quantifying Information Conveyed by Large Neuronal Populations. (2019) Neural Computation.:1-33 DOI: 10.1162/neco_a_01193

+ expand abstract


Zhou, Y., Smith, B.H., Sharpee, T.O. Hyperbolic geometry of the olfactory space. (2018) Science advances. 4(8):eaaq1458. DOI: 10.1126/sciadv.aaq1458

+ expand abstract


Atencio, C.A., Sharpee, T.O. Multidimensional receptive field processing by cat primary auditory cortical neurons. (2017) Neuroscience. 359:130-141. DOI: 10.1016/j.neuroscience.2017.07.003

+ expand abstract


Sharpee, T.O. On texture, form, and fixational eye movements. (2017) Current Opinion in Neurobiology. 46:228-233. DOI: 10.1016/j.conb.2017.09.002

+ expand abstract


Kaardal, J.T., Theunissen, F.E., Sharpee, T.O. A Low-Rank Method for Characterizing High-Level Neural Computations. (2017) Frontiers in Computational Neuroscience. 11:68. DOI: 10.3389/fncom.2017.00068

+ expand abstract


Sharpee, T.O. Optimizing Neural Information Capacity through Discretization. (2017) Neuron. 94(5):954-960. DOI: 10.1016/j.neuron.2017.04.044

+ expand abstract


Rowekamp, R.J., Sharpee, T.O. Cross-orientation suppression in visual area V2. (2017) Nature Communications. 8:15739. DOI: 10.1038/ncomms15739

+ expand abstract


Sharpee, T.O. Plasticity to the Rescue. (2016) Neuron. 92(5):935-936. DOI: 10.1016/j.neuron.2016.11.042

+ expand abstract


Kuczala, A., Sharpee, T.O. Eigenvalue spectra of large correlated random matrices. (2016) Phys Rev E. 94(5-1):050101. DOI: 10.1103/PhysRevE.94.050101

+ expand abstract


Sharpee, T.O. How Invariant Feature Selectivity Is Achieved in Cortex. (2016) Front Synaptic Neurosci. 8:26. DOI: 10.3389/fnsyn.2016.00026

+ expand abstract


Sharpee, T.O. Taking a close look at electrosensing. (2016) Elife. 5. DOI: 10.7554/eLife.16209

+ expand abstract


Zhang, Y., Sharpee, T.O. A Robust Feedforward Model of the Olfactory System. (2016) PLOS Computational Biology. 12(4):e1004850. DOI: 10.1371/journal.pcbi.1004850

+ expand abstract


Aljadeff, J., Renfrew, D., Vegué, M., Sharpee, T.O. Low-dimensional dynamics of structured random networks. (2016) Phys Rev E. 93(2):022302. DOI: 10.1103/PhysRevE.93.022302

+ expand abstract


Hinckley, C.A., Alaynick, W.A., Gallarda, B.W., Hayashi, M., Hilde, K.L., Driscoll, S.P., Dekker, J.D., Tucker, H.O., Sharpee, T.O., Pfaff, S.L. Spinal Locomotor Circuits Develop Using Hierarchical Rules Based on Motorneuron Position and Identity. (2015) Neuron. 87(5):1008-21. DOI: 10.1016/j.neuron.2015.08.005

+ expand abstract


Calhoun, A.J., Tong, A., Pokala, N., Fitzpatrick, J.A., Sharpee, T.O., Chalasani, S.H. Neural Mechanisms for Evaluating Environmental Variability in Caenorhabditis elegans. (2015) Neuron. 86(2):428-41. DOI: 10.1016/j.neuron.2015.03.026

+ expand abstract


Aljadeff, J., Stern, M., Sharpee, T. Transition to chaos in random networks with cell-type-specific connectivity. (2015) Phys. Rev. Lett. 114(8):088101. DOI: 10.1103/PhysRevLett.114.088101

+ expand abstract


Kastner, D.B., Baccus, S.A., Sharpee, T.O. Critical and maximally informative encoding between neural populations in the retina. (2015) Proceedings of the National Academy of Sciences of the United States of America. 112(8):2533-8. DOI: 10.1073/pnas.1418092112

+ expand abstract


Calhoun, A.J., Chalasani, S.H., Sharpee, T.O. Maximally informative foraging by Caenorhabditis elegans. (2014) Elife. 3. DOI: 10.7554/eLife.04220

+ expand abstract


Sharpee, T.O. Toward functional classification of neuronal types. (2014) Neuron. 83(6):1329-34. DOI: 10.1016/j.neuron.2014.08.040

+ expand abstract


Sharpee, T.O. Function determines structure in complex neural networks. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(23):8327-8. DOI: 10.1073/pnas.1407198111


Sharpee, T.O., Calhoun, A.J., Chalasani, S.H. Information theory of adaptation in neurons, behavior, and mood. (2014) Current Opinion in Neurobiology. 25:47-53. DOI: 10.1016/j.conb.2013.11.007

+ expand abstract


Morris, R., Sancho-Martinez, I., Sharpee, T.O., Izpisua Belmonte, J.C. Mathematical approaches to modeling development and reprogramming. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(14):5076-82. DOI: 10.1073/pnas.1317150111

+ expand abstract


Aljadeff, J., Segev, R., Berry, M.J., Sharpee, T.O. Spike triggered covariance in strongly correlated gaussian stimuli. (2013) PLOS Computational Biology. 9(9):e1003206. DOI: 10.1371/journal.pcbi.1003206

+ expand abstract


Sharpee, T.O. Computational identification of receptive fields. (2013) Annual Review of Neuroscience. 36:103-20. DOI: 10.1146/annurev-neuro-062012-170253

+ expand abstract


Sharpee, T.O., Kouh, M., Reynolds, J.H. Trade-off between curvature tuning and position invariance in visual area V4. (2013) Proceedings of the National Academy of Sciences of the United States of America. 110(28):11618-23. DOI: 10.1073/pnas.1217479110

+ expand abstract


Kaardal, J., Fitzgerald, J.D., Berry, M.J., Sharpee, T.O. Identifying functional bases for multidimensional neural computations. (2013) Neural Computation. 25(7):1870-90. DOI: 10.1162/NECO_a_00465

+ expand abstract


Nandy, A.S., Sharpee, T.O., Reynolds, J.H., Mitchell, J.F. The fine structure of shape tuning in area V4. (2013) Neuron. 78(6):1102-15. DOI: 10.1016/j.neuron.2013.04.016

+ expand abstract


Saremi, S., Sejnowski, T.J., Sharpee, T.O. Double-gabor filters are independent components of small translation-invariant image patches. (2013) Neural Computation. 25(4):922-39. DOI: 10.1162/NECO_a_00418

+ expand abstract


Jeanne, J.M., Sharpee, T.O., Gentner, T.Q. Associative learning enhances population coding by inverting interneuronal correlation patterns. (2013) Neuron. 78(2):352-63. DOI: 10.1016/j.neuron.2013.02.023

+ expand abstract


Eickenberg, M., Rowekamp, R.J., Kouh, M., Sharpee, T.O. Characterizing responses of translation-invariant neurons to natural stimuli: maximally informative invariant dimensions. (2012) Neural Computation. 24(9):2384-421. DOI: 10.1162/NECO_a_00330

+ expand abstract


Atencio, C.A., Sharpee, T.O., Schreiner, C.E. Receptive field dimensionality increases from the auditory midbrain to cortex. (2012) Journal of Neurophysiology. 107(10):2594-603. DOI: 10.1152/jn.01025.2011

+ expand abstract


Sharpee, T.O. Adaptive switches in midbrain circuits. (2012) Neuron. 73(1):6-7. DOI: 10.1016/j.neuron.2011.12.017

+ expand abstract


Fitzgerald, J.D., Rowekamp, R.J., Sincich, L.C., Sharpee, T.O. Second order dimensionality reduction using minimum and maximum mutual information models. (2011) PLOS Computational Biology. 7(10):e1002249. DOI: 10.1371/journal.pcbi.1002249

+ expand abstract


Sharpee, T.O., Nagel, K.I., Doupe, A.J. Two-dimensional adaptation in the auditory forebrain. (2011) Journal of Neurophysiology. 106(4):1841-61. DOI: 10.1152/jn.00905.2010

+ expand abstract


Sharpee, T.O., Atencio, C.A., Schreiner, C.E. Hierarchical representations in the auditory cortex. (2011) Current Opinion in Neurobiology. 21(5):761-7. DOI: 10.1016/j.conb.2011.05.027

+ expand abstract


Rowekamp, R.J., Sharpee, T.O. Analyzing multicomponent receptive fields from neural responses to natural stimuli. (2011) Network. 22(1-4):45-73. DOI: 10.3109/0954898X.2011.566303

+ expand abstract


Fitzgerald, J.D., Sincich, L.C., Sharpee, T.O. Minimal models of multidimensional computations. (2011) PLOS Computational Biology. 7(3):e1001111. DOI: 10.1371/journal.pcbi.1001111

+ expand abstract


Jeanne, J.M., Thompson, J.V., Sharpee, T.O., Gentner, T.Q. Emergence of learned categorical representations within an auditory forebrain circuit. (2011) Journal of Neuroscience. 31(7):2595-606. DOI: 10.1523/JNEUROSCI.3930-10.2011

+ expand abstract


Imaizumi, K., Priebe, N.J., Sharpee, T.O., Cheung, S.W., Schreiner, C.E. Encoding of temporal information by timing, rate, and place in cat auditory cortex. (2010) PLOS One. 5(7):e11531. DOI: 10.1371/journal.pone.0011531

+ expand abstract


Gallarda, B.W., Sharpee, T.O., Pfaff, S.L., Alaynick, W.A. Defining rhythmic locomotor burst patterns using a continuous wavelet transform. (2010) Ann. N. Y. Acad. Sci. 1198:133-9. DOI: 10.1111/j.1749-6632.2010.05437.x

+ expand abstract


Atencio, C.A., Sharpee, T.O., Schreiner, C.E. Hierarchical computation in the canonical auditory cortical circuit. (2009) Proceedings of the National Academy of Sciences of the United States of America. 106(51):21894-9. DOI: 10.1073/pnas.0908383106

+ expand abstract


Fitzgerald, J.D., Sharpee, T.O. Maximally informative pairwise interactions in networks. (2009) Phys Rev E Stat Nonlin Soft Matter Phys. 80(3 Pt 1):031914. DOI: 10.1103/PhysRevE.80.031914

+ expand abstract


Liu, Y.S., Stevens, C.F., Sharpee, T.O. Predictable irregularities in retinal receptive fields. (2009) Proceedings of the National Academy of Sciences of the United States of America. 106(38):16499-504. DOI: 10.1073/pnas.0908926106

+ expand abstract


Sincich, L.C., Horton, J.C., Sharpee, T.O. Preserving information in neural transmission. (2009) Journal of Neuroscience. 29(19):6207-16. DOI: 10.1523/JNEUROSCI.3701-08.2009

+ expand abstract


Sharpee, T.O., Victor, J.D. Contextual modulation of V1 receptive fields depends on their spatial symmetry. (2009) Journal of Computational Neuroscience. 26(2):203-18. DOI: 10.1007/s10827-008-0107-5

+ expand abstract


Kouh, M., Sharpee, T.O. Estimating linear-nonlinear models using Renyi divergences. (2009) Network. 20(2):49-68. DOI: 10.1080/09548980902950891

+ expand abstract


Atencio, C.A., Sharpee, T.O., Schreiner, C.E. Cooperative nonlinearities in auditory cortical neurons. (2008) Neuron. 58(6):956-66. DOI: 10.1016/j.neuron.2008.04.026

+ expand abstract


Sharpee, T.O., Miller, K.D., Stryker, M.P. On the importance of static nonlinearity in estimating spatiotemporal neural filters with natural stimuli. (2008) Journal of Neurophysiology. 99(5):2496-509. DOI: 10.1152/jn.01397.2007

+ expand abstract


Clifford, C.W., Webster, M.A., Stanley, G.B., Stocker, A.A., Kohn, A., Sharpee, T.O., Schwartz, O. Visual adaptation: neural, psychological and computational aspects. (2007) Vision Research. 47(25):3125-31. DOI: 10.1016/j.visres.2007.08.023

+ expand abstract


Sharpee, T.O. Comparison of information and variance maximization strategies for characterizing neural feature selectivity. (2007) Stat Med. 26(21):4009-31. DOI: 10.1002/sim.2931

+ expand abstract


Sharpee, T., Bialek, W. Neural decision boundaries for maximal information transmission. (2007) PLOS One. 2(7):e646. DOI: 10.1371/journal.pone.0000646

+ expand abstract


Sharpee, T.O., Sugihara, H., Kurgansky, A.V., Rebrik, S.P., Stryker, M.P., Miller, K.D. Adaptive filtering enhances information transmission in visual cortex. (2006) Nature. 439(7079):936-42. DOI: 10.1038/nature04519

+ expand abstract


Victor, J.D., Mechler, F., Repucci, M.A., Purpura, K.P., Sharpee, T. Responses of V1 neurons to two-dimensional hermite functions. (2006) Journal of Neurophysiology. 95(1):379-400. DOI: 10.1152/jn.00498.2005

+ expand abstract


Sharpee, T., Rust, N.C., Bialek, W. Analyzing neural responses to natural signals: maximally informative dimensions. (2004) Neural Computation. 16(2):223-50. DOI: 10.1162/089976604322742010

+ expand abstract


Dykman, M.I., Sharpee, T., Platzman, P.M. Enhancement of tunneling from a correlated 2D electron system by a many-electron Mössbauer-type recoil in a magnetic field. (2001) Phys. Rev. Lett. 86(11):2408-11. DOI: 10.1103/PhysRevLett.86.2408

+ expand abstract


Barabash-Sharpee, T., Dykman, M.I., Platzman, P.M. Tunneling transverse to a magnetic field and its occurrence in correlated 2D electron systems. (2000) Phys. Rev. Lett. 84(10):2227-30. DOI: 10.1103/PhysRevLett.84.2227

+ expand abstract


Education

MS, Physics, Ukraine National University, Kiev, Ukraine
PhD, Physics, Michigan State University
Sloan-Swartz Postdoctoral Fellow, University of California, San Francisco


Affiliations


Awards & Honors

  • 2018 Fellow of the American Physical Society
  • 2013 National Science Foundation (NSF) CAREER award
  • 2010 Helen McLoraine Developmental Chair in Neurobiology
  • 2009 W.M. Keck Foundation Research Excellence Award
  • 2009 McKnight Scholar
  • 2008 Searle Scholar